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Aliases for TPRXL Gene

Aliases for TPRXL Gene

  • Tetrapeptide Repeat Homeobox Like 2 3 5
  • Tetra-Peptide Repeat Homeobox-Like 3
  • TPRX3P 3

External Ids for TPRXL Gene

Previous GeneCards Identifiers for TPRXL Gene

  • GC03P013954
  • GC03P013978
  • GC03P013912

Summaries for TPRXL Gene

Entrez Gene Summary for TPRXL Gene

  • Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the TPRX homeobox gene family. [provided by RefSeq, Jul 2008]

GeneCards Summary for TPRXL Gene

TPRXL (Tetrapeptide Repeat Homeobox Like) is a Pseudogene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPRXL Gene

Genomics for TPRXL Gene

Regulatory Elements for TPRXL Gene

Enhancers for TPRXL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F014016 0.5 ENCODE 7.3 +79.9 79934 1.3 KLF1 RFX1 NFIA KLF17 MAFG ZIC2 IKZF1 GLIS1 KLF9 ZNF24 TPRXL CHCHD4 PIR57574 VN1R21P
GH03F014000 0.6 ENCODE 7.2 +64.0 63977 1.9 ATF3 BCL11A NFE2 TRIM24 EMSY SP7 ZEB1 WNT7A TPRXL XPC VN1R20P CHCHD4 PIR57574 VN1R21P
GH03F014122 1.3 FANTOM5 ENCODE 7 +188.0 187964 5.4 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CBX5 ZNF143 CHCHD4 FGD5 ENSG00000228242 XPC VN1R20P TMEM43 TPRXL ENSG00000268279
GH03F014132 0.2 ENCODE 6.9 +196.1 196095 1.2 SAP130 CEBPG TEAD3 ZNF664 FOSL1 GATA2 ZNF366 SP5 CEBPB ATF2 XPC LSM3 CHCHD4 TPRXL ENSG00000268279 TMEM43
GH03F013963 0.5 ENCODE 0.3 +26.1 26083 0.2 SREBF1 GATA3 RFX1 ATF3 JUN FOS PIR57574 TPRXL
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TPRXL on UCSC Golden Path with GeneCards custom track

Genomic Location for TPRXL Gene

Chromosome:
3
Start:
13,937,273 bp from pter
End:
14,082,811 bp from pter
Size:
145,539 bases
Orientation:
Plus strand

Genomic View for TPRXL Gene

Genes around TPRXL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPRXL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPRXL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPRXL Gene

Proteins for TPRXL Gene

  • Protein details for TPRXL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RH7-TPRXL_HUMAN
    Recommended name:
    Putative protein TPRXL
    Protein Accession:
    Q17RH7
    Secondary Accessions:
    • Q8NAM5

    Protein attributes for TPRXL Gene

    Size:
    258 amino acids
    Molecular mass:
    24139 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TPRXL Gene

Post-translational modifications for TPRXL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TPRXL Gene

Domains & Families for TPRXL Gene

Gene Families for TPRXL Gene

Protein Domains for TPRXL Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TPRXL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TPRXL: view

No data available for UniProtKB/Swiss-Prot for TPRXL Gene

Function for TPRXL Gene

Phenotypes for TPRXL Gene

GenomeRNAi human phenotypes for TPRXL:
genes like me logo Genes that share phenotypes with TPRXL: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TPRXL Gene

Localization for TPRXL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPRXL Gene COMPARTMENTS Subcellular localization image for TPRXL gene
Compartment Confidence
nucleus 2
cytosol 1
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TPRXL Gene

Pathways & Interactions for TPRXL Gene

SuperPathways for TPRXL Gene

No Data Available

Interacting Proteins for TPRXL Gene

Selected Interacting proteins: Q17RH7-TPRXL_HUMAN for TPRXL Gene via IID

Symbol External ID(s) Details
APP

Gene Ontology (GO) - Biological Process for TPRXL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TPRXL Gene

Transcripts for TPRXL Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TPRXL Gene

No ASD Table

Relevant External Links for TPRXL Gene

GeneLoc Exon Structure for
TPRXL
ECgene alternative splicing isoforms for
TPRXL

Expression for TPRXL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TPRXL Gene

mRNA differential expression in normal tissues according to GTEx for TPRXL Gene

This gene is overexpressed in Esophagus - Mucosa (x18.2), Vagina (x6.0), and Testis (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of TPRXL Gene:

TPRXL

SOURCE GeneReport for Unigene cluster for TPRXL Gene:

Hs.529180
genes like me logo Genes that share expression patterns with TPRXL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TPRXL Gene

Orthologs for TPRXL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TPRXL Gene

Organism Taxonomy Gene Similarity Type Details
wheat
(Triticum aestivum)
Liliopsida Ta.22819 34
Species where no ortholog for TPRXL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TPRXL Gene

ENSEMBL:
Gene Tree for TPRXL (if available)
TreeFam:
Gene Tree for TPRXL (if available)

Paralogs for TPRXL Gene

No data available for Paralogs for TPRXL Gene

Variants for TPRXL Gene

Sequence variations from dbSNP and Humsavar for TPRXL Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10154884 -- 13,993,769(+) ttgct(C/T)gttag intron-variant
rs10212440 -- 14,010,362(+) tgtat(A/G)tgtgt intron-variant
rs10575463 -- 13,937,239(+) AGCCA(-/CTAT)CTATC downstream-variant-500B, upstream-variant-2KB
rs1077325 -- 13,951,149(-) ctata(C/T)ccctg intron-variant
rs111244615 -- 13,959,924(+) ATTCA(A/G)CTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPRXL Gene

Variant ID Type Subtype PubMed ID
esv2584514 CNV insertion 19546169
esv2629351 CNV deletion 19546169
esv2724945 CNV deletion 23290073
esv2763224 CNV loss 21179565
esv3331951 CNV duplication 20981092
esv34163 CNV loss 18971310
esv3595356 CNV loss 21293372
esv3595357 CNV loss 21293372
esv3595358 CNV loss 21293372
esv3595359 CNV loss 21293372
nsv1010313 CNV loss 25217958
nsv1011766 CNV gain 25217958
nsv3711 CNV insertion 18451855
nsv512797 CNV insertion 21212237
nsv526467 CNV loss 19592680

Variation tolerance for TPRXL Gene

Gene Damage Index Score: 10.74; 91.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPRXL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TPRXL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPRXL Gene

Disorders for TPRXL Gene

Relevant External Links for TPRXL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPRXL

No disorders were found for TPRXL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPRXL Gene

Publications for TPRXL Gene

  1. Whole exome sequencing in a case of sporadic multiple meningioma reveals shared NF2, FAM109B, and TPRXL mutations, together with unique SMARCB1 alterations in a subset of tumor nodules. (PMID: 25981829) Torres-MartA-n M. … Rey J.A. (Cancer Genet 2015) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women. (PMID: 22116950) Schuh-Huerta S.M. … Reijo Pera R.A. (Hum. Reprod. 2012) 3 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for TPRXL Gene

Sources for TPRXL Gene

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