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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TPRXL Gene

pseudogene GIFtS: 34
GCID: GC03P013978

tetra-peptide repeat homeobox-like

Search for TPRXL
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tetra-Peptide Repeat Homeobox-Like¹ ²
FLJ35107¹

External Ids:	HGNC: 32178¹	Entrez Gene: 348825²	Ensembl: ENSG00000180438⁷	OMIM: 611167⁵	UniProtKB: Q17RH7³

Export aliases for TPRXL gene to outside databases

Previous GC identifers: GC03P013954 GC03P013912

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TPRXL:

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development.

Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is

a member of the TPRX homeobox gene family. (provided by RefSeq, Jul 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TPRXL gene promoter:
MZF-1 p53 AML1a GR-beta Cart-1 CUTL1 Cdc5 c-Ets-1 YY1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPRXL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.1 Ensembl cytogenetic band: 3p25.1 HGNC cytogenetic band: 3p25.1

TPRXL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPRXL gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P013978: view genomic region (about GC identifiers)

Start:	13,978,756 bp from pter	End:	14,124,311 bp from pter
Size:	145,556 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TPRXL_HUMAN, Q17RH7 (See protein sequence)

Recommended Name: Putative protein TPRXL

Size: 258 amino acids; 24139 Da

Caution: Could be the product of a pseudogene

Secondary accessions: Q8NAM5

Explore the universe of human proteins at neXtProt for TPRXL: NX_Q17RH7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q17RH7

TPRXL Protein expression data from MOPED and PaxDb: About this image

ENSEMBL proteins:

ENSP00000437227 ENSP00000435853 ENSP00000435219 ENSP00000322097 ENSP00000436919

ENSP00000435227 ENSP00000400448 ENSP00000435438 ENSP00000400824 ENSP00000432662

ENSP00000435511

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q17RH7

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TPRXL

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

Unigene Clusters for TPRXL:

Tetra-peptide repeat homeobox-like

Hs.529180 [show with all ESTs], Hs.638296

Unigene Representative Sequences: NR_002223, BC027729

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000532880 ENST00000530586 ENST00000532753 ENST00000524375 ENST00000326972(uc011avd.2)

ENST00000529129 ENST00000528312 ENST00000424053(uc021wtk.1 uc003byg.3)

ENST00000528067 ENST00000429201 ENST00000532924 ENST00000528040

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Additional cDNA sequence: BC027729.2

6 DOTS entries:

DT.101978527 DT.40232462 DT.100718525 DT.99935760 DT.120844139 DT.120844141

24/29 AceView cDNA sequences (see all 29):

BU754588 AW303358 AI453103 CR613670 BM764893 BM764898 BX111860 BX379920

BC016304 BM764892 CF994921 AX747539 BG481805 BC027729 BX379919 CD109930

AK092426 BX371689 CB959908 BG001685 AW138905 BM811485 BG006231 R82240

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TPRXL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAATTGAAC

About this image

TPRXL expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Secondary Oocyte

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TPRXL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TPRXL

SOURCE GeneReport for Unigene clusters: Hs.529180 Hs.638296

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TPRXL gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Obox3⁵	oocyte specific homeobox 3	--		7 (8.53 cM) 15625302
fruit fly (Drosophila melanogaster)	Insecta	Mur29B⁶	Mucin related 29B	9(a)	1 ↔ 1	2L(8352187-8355172)
wheat (Triticum aestivum)	Liliopsida	Ta.22819²	Triticum aestivum transcribed sequence with weak similarity more	71.43(n)		CD874909.1

ENSEMBL Gene Tree for TPRXL (if available)
TreeFam Gene Tree for TPRXL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TPRXL gene

ZCCHC10² RNPS1² PNN²

TPRXL for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11128668^1,2	C,F,A,H	--	13976830(+)	`GAGCTG/ATTCTC`	2	--	nc-transcript-variantus2k¹		23		NS EA NA WA	2574
rs186146423^1,2		--	13976833(+)	`CTGTTC/TTCCTT`	2	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs150547392^1,2		--	13976897(+)	`TGTGCA/GGAGGA`	2	--	nc-transcript-variantus2k¹		0	--	--	--	--
rs73814756^1,2	C	--	13976904(+)	`AGGAGG/AACCCC`	2	--	nc-transcript-variantus2k¹		2		WA	120
rs139513957^1,2		--	13977005(+)	`GAGGAA/GGAGAA`	2	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs114894105^1,2	F	--	13977047(+)	`AACCCC/TTATGT`	2	--	us2k¹ nc-transcript-variant		1		WA	118
rs150036784^1,2		--	13977072(+)	`TGCTGG/TGAGGA`	2	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs192206295^1,2		--	13977105(+)	`GAGTTA/CGTGGA`	2	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs13091307^1,2	H	--	13977106(+)	`agTTCG/TTGGAT`	2	--	us2k¹ nc-transcript-variant		4		NS EA	420
rs72582720^1,2	C	--	13977201(+)	`CACGC-/GGTGGC`	2	--	nc-transcript-variantus2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TPRXL (13978756 - 14124311 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TPRXL
1 CNV: 48019
2 Indels: 98239 98240

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TPRXL for disorders About MalaCards

TPRXL for disorders About GeneDecksing

OMIM gene information: 611167 OMIM disorders: --

Export disorders for TPRXL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TPRXL gene integrated from 9 sources:
(articles sorted by number of sources associating them with TPRXL)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women . (PubMed id 22116950)¹ Schuh-Huerta S.M....Reijo Pera R.A. (2012)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 348825	HGNC: 32178	AceView: FLJ35107	Ensembl:ENSG00000180438	euGenes: HUgn348825
ECgene: TPRXL	H-InvDB: TPRXL

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TPRXL	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TPRXL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TPRXL gene:
Search GeneIP for patents involving TPRXL

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TPRXL gene at Home site.

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TPRXL Gene

tetra-peptide repeat homeobox-like

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TPRXL Gene

tetra-peptide repeat homeobox-like

Aliasesfor TPRXL gene

Summariesfor TPRXL gene

Genomic Viewsfor TPRXL gene

Proteinsfor TPRXL gene

Protein Domains /Familiesfor TPRXL gene

Functionfor TPRXL gene

Pathways & Interactionsfor TPRXL gene

Drugs & Compoundsfor TPRXL gene

Transcriptsfor TPRXL gene

Expression for TPRXL gene

Orthologsfor TPRXL gene

Paralogsfor TPRXL gene

Genomic Variantsfor TPRXL gene

Disorders / Diseasesfor TPRXL gene

Publicationsfor TPRXL gene

External Searches for TPRXL gene

Genome Databases showing TPRXL gene

Other Databases showing TPRXL gene

Specialized Databases showing TPRXL gene

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Productsfor TPRXL gene

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Aliases
for TPRXL gene

Summaries
for TPRXL gene

Genomic Views
for TPRXL gene

Proteins
for TPRXL gene

Protein Domains /
Families
for TPRXL gene

Function
for TPRXL gene

Pathways & Interactions
for TPRXL gene

Drugs & Compounds
for TPRXL gene

Transcripts
for TPRXL gene

Expression
for TPRXL gene

Orthologs
for TPRXL gene

Paralogs
for TPRXL gene

Genomic Variants
for TPRXL gene

Disorders / Diseases
for TPRXL gene

Publications
for TPRXL gene

Intellectual Property
for TPRXL gene

Products
for TPRXL gene