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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TPRXL Gene

pseudogene   GIFtS: 33
GCID: GC03P013978

Tetra-Peptide Repeat Homeobox-Like

  Search for TPRXL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tetra-Peptide Repeat Homeobox-Like1 2

External Ids:    HGNC: 321781   Entrez Gene: 3488252   Ensembl: ENSG000001804387   OMIM: 6111675   UniProtKB: Q17RH73   

Export aliases for TPRXL gene to outside databases

Previous GC identifers: GC03P013954 GC03P013912


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TPRXL Gene:
Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic
development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain.
This pseudogene is a member of the TPRX homeobox gene family. (provided by RefSeq, Jul 2008)

GeneCards Summary for TPRXL Gene: 
TPRXL (tetra-peptide repeat homeobox-like) is a pseudogene.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TPRXL gene promoter:
         MZF-1   p53   AML1a   GR-beta   Cart-1   CUTL1   Cdc5   c-Ets-1   YY1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TPRXL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPRXL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.1   Ensembl cytogenetic band:  3p25.1   HGNC cytogenetic band: 3p25.1

TPRXL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPRXL gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P013978:  view genomic region     (about GC identifiers)

Start:
13,978,756 bp from pter      End:
14,124,311 bp from pter
Size:
145,556 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TPRXL_HUMAN, Q17RH7 (See protein sequence)
Recommended Name: Putative protein TPRXL  
Size: 258 amino acids; 24139 Da
Caution: Could be the product of a pseudogene
Secondary accessions: Q8NAM5

Explore the universe of human proteins at neXtProt for TPRXL: NX_Q17RH7

Explore proteomics data for TPRXL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q17RH7

  • TPRXL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TPRXL Protein Expression

    ENSEMBL proteins: 
     ENSP00000437227   ENSP00000435853   ENSP00000435219   ENSP00000322097   ENSP00000436919  
     ENSP00000435227   ENSP00000400448   ENSP00000435438   ENSP00000400824   ENSP00000432662  
     ENSP00000435511  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PRD: Homeoboxes / PRD class

    ProtoNet protein and cluster: Q17RH7


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TPRXL

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TPRXL

    Search CenterWatch for drugs/clinical trials and news about TPRXL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    Unigene Clusters for TPRXL:

    Tetra-peptide repeat homeobox-like
    Hs.529180  [show with all ESTs], Hs.638296
    Unigene Representative Sequences: NR_002223, BC027729
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000532880 ENST00000530586 ENST00000532753 ENST00000524375 ENST00000326972(uc011avd.2)
    ENST00000529129 ENST00000528312 ENST00000424053(uc021wtk.1 uc003byg.3)
    ENST00000528067 ENST00000429201 ENST00000532924 ENST00000528040
    miRNA
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    Additional mRNA sequence: BC027729.2 

    6 DOTS entries:

    DT.101978527  DT.40232462  DT.100718525  DT.99935760  DT.120844139  DT.120844141 

    24/29 AceView cDNA sequences (see all 29):

    AW303358 CR613670 BX111860 AI453103 BM764898 BU754588 BM764893 AX747539 
    AK092426 CD109930 CF994921 BG481805 CB959908 BX379919 BM764892 BX371689 
    BX379920 BC027729 BC016304 BG001685 AW138905 BM811485 R82240 BG006231 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TPRXL expression in normal human tissues (normalized intensities)      TPRXL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAATTGAAC
    TPRXL Expression
    About this image


    TPRXL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     Placenta (Extraembryonic Tissues)

    See TPRXL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TPRXL

    SOURCE GeneReport for Unigene clusters: Hs.529180 Hs.638296
        SABiosciences Custom PCR Arrays for TPRXL
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPRXL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TPRXL gene from 7/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Obox35 oocyte specific homeobox 3   --   7 (8.53 cM) 15625302 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein

    1 → many
    AAWZ02039442(3120-4489)
    zebrafish
    (Danio rerio)
    Actinopterygii MUC216
    mucin 21, cell surface associated
    1(a)
    1 → many
    11(45056877-45058136)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG425256
    CG109116
    --
    2(a)
    1(a)
    many ↔ many
    many ↔ many
    3L(3188025-3189747)
    2R(13940052-13941569)
    worm
    (Caenorhabditis elegans)
    Secernentea C15B12.46
    Protein C15B12.4
    2(a)
    1 → many
    X(6470366-6473748)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRP406
    Nucleolar, serine-rich protein with a role in prer...
    17(a)
    1 → many
    XI(612665-613885)
    wheat
    (Triticum aestivum)
    Liliopsida Ta.228192 Triticum aestivum transcribed sequence with weak similarity more 71.43(n)    CD874909.1 


    ENSEMBL Gene Tree for TPRXL (if available)
    TreeFam Gene Tree for TPRXL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2471 SNPs in TPRXL are shown (see all 2471)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1159472471,2
    C,F--13978968(+) GACCAG/AGACGC 1 -- nc-transcript-variant1Minor allele frequency- A:0.03WA 118
    rs1877127671,2
    --13979106(+) GACTTG/TGGGTG 1 -- int10--------
    rs1456011871,2
    --13979136(+) GCCCTA/GGTTAC 1 -- int10--------
    rs1932195331,2
    C--13979176(+) TCACAA/GCAGAT 1 -- int10--------
    rs1856292481,2
    --13979265(+) TTTTTC/TTTTGA 1 -- int10--------
    rs1381220871,2
    --13979309(+) GCAGCA/GGCACC 1 -- int10--------
    rs1884653791,2
    --13979371(+) TCAGCC/TTCCCG 1 -- int10--------
    rs1494701741,2
    --13979493(+) TGATCC/TGCCCA 1 -- int10--------
    rs1153776421,2
    C,F--13979557(+) ATCTCC/TTAGGT 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1438473271,2
    --13979742(+) TTCAAA/GTGATT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TPRXL (13978756 - 14124311 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for TPRXL:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2629351CNV Deletion19546169
    esv2724945CNV Deletion23290073
    esv2584514CNV Insertion19546169
    esv273722CNV Insertion20981092
    nsv512797CNV Insertion21212237
    nsv3711CNV Insertion18451855
    esv269558CNV Insertion20981092
    nsv526467CNV Loss19592680
    nsv876550CNV Loss21882294
    esv34163CNV Loss18971310

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TPRXL for disorders           About MalaCards
    OMIM gene information: 611167    OMIM disorders: --


    TPRXL for disorders           About GeneDecksing


    Export disorders for TPRXL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TPRXL gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TPRXL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women . (PubMed id 22116950)1 Schuh-Huerta S.M....Reijo Pera R.A. (2012)
    3. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 348825 HGNC: 32178 AceView: FLJ35107 Ensembl:ENSG00000180438 euGenes: HUgn348825
    ECgene: TPRXL H-InvDB: TPRXL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TPRXL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TPRXL gene:
    Search GeneIP for patents involving TPRXL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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