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TPRX1 Gene

protein-coding   GIFtS: 37
GCID: GC19M048304

Tetra-Peptide Repeat Homeobox 1

  Search for TPRX1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tetra-Peptide Repeat Homeobox 11 2
TPRX2
CRX Like Homeobox 22
Tetra-Peptide Repeat Homeobox Protein 12

External Ids:    HGNC: 321741   Entrez Gene: 2843552   Ensembl: ENSG000001789287   OMIM: 6111665   UniProtKB: Q8N7U73   

Export aliases for TPRX1 gene to outside databases

Previous GC identifers: GC19M052998 GC19M044730


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TPRX1 Gene:
Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic
development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain.
This gene is a member of the TPRX homeobox gene family. (provided by RefSeq, Jul 2008)

GeneCards Summary for TPRX1 Gene:
TPRX1 (tetra-peptide repeat homeobox 1) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TPRX2P.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TPRX1 gene promoter:
         GATA-3   AP-1   MEF-2   ATF-2   MEF-2A   Ik-2   STAT3   c-Jun   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTPRX1 promoter sequence
   Search Chromatin IP Primers for TPRX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPRX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

TPRX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPRX1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M048304:  view genomic region     (about GC identifiers)

Start:
48,304,500 bp from pter      End:
48,322,308 bp from pter
Size:
17,809 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
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UniProtKB/Swiss-Prot: TPRX1_HUMAN, Q8N7U7 (See protein sequence)
Recommended Name: Tetra-peptide repeat homeobox protein 1  
Size: 411 amino acids; 40603 Da
Secondary accessions: A5D8Y3 B2RPL5
Alternative splicing: 2 isoforms:  Q8N7U7-1   Q8N7U7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TPRX1: NX_Q8N7U7

REFSEQ proteins: NP_940881.2  
ENSEMBL proteins: 
 ENSP00000323455   ENSP00000438832   ENSP00000438712  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
PRD: Homeoboxes / PRD class

2 InterPro protein domains:
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q8N7U7

ProtoNet protein and cluster: Q8N7U7

UniProtKB/Swiss-Prot: TPRX1_HUMAN, Q8N7U7
Similarity: Contains 1 homeobox DNA-binding domain


Find genes that share domains with TPRX1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding IEA--
     
Find genes that share ontologies with TPRX1           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for TPRX1:
 Cell cycle / mitosis defect  Decreased influenza A virus in 

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TPRX1_HUMAN, Q8N7U7: Nucleus (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
mitochondrion2
cytosol1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

Find genes that share ontologies with TPRX1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

    Search GeneGlobe Interaction Network for TPRX1

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006355regulation of transcription, DNA-templated ----

Find genes that share ontologies with TPRX1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TPRX1 gene: 
NM_198479.2  

Unigene Cluster for TPRX1:

Tetra-peptide repeat homeobox 1
Hs.629812  [show with all ESTs]
Unigene Representative Sequence: NM_198479
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000322175(uc002php.2) ENST00000535759 ENST00000543508
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Additional mRNA sequence: 

AK097640.1 BC137501.1 BC141863.1 BC144673.1 DQ340180.1 

1 DOTS entry:

DT.99930898 

5 AceView cDNA sequences:

BM661638 BV192016 AK097640 NM_198479 BM689672 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TPRX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TPRX1 Expression
About this image

TPRX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.629812
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for TPRX1 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia TPRX16
tetra-peptide repeat homeobox 1
76(a)
1 ↔ 1
19(52739745-52759036)


ENSEMBL Gene Tree for TPRX1 (if available)
TreeFam Gene Tree for TPRX1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TPRX1 gene
TPRX2P2  
6 SIMAP similar genes for TPRX1 using alignment to 3 protein entries:     TPRX1_HUMAN (see all proteins):
TPRX2P    NKX2-5    DUX2    MNX1    POU6F1    HOXA4

Find genes that share paralogs with TPRX1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TPRX1 (see all 149)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1424995871,2
C--48304001(+) AAGTC-/ATTTT 
        
ATTTT
1 -- ds50010--------
rs81090571,2
C,F,A,H--48304046(+) tctcaT/Gtctgt 1 -- ds500110Minor allele frequency- G:0.23NA WA CSA EA 371
rs1825065591,2
--48304104(+) CACCTA/CCTAGG 1 -- ds50010--------
rs116684461,2
C,F,A,H--48304106(+) CCTCCC/TAGGTT 1 -- ds50017Minor allele frequency- T:0.50NA CSA 14
rs116723111,2
C,F,A,H--48304174(+) ATGCCT/CGGCTA 1 -- ds50015Minor allele frequency- C:0.40NA CSA 10
rs81089141,2
C,A,H--48304197(+) ttattT/Attttt 1 -- ds50018Minor allele frequency- A:0.29NA WA CSA 249
rs1119028601,2
C--48304246(+) TCTCAG/AACTCT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
rs116723151,2
C,F,A,H--48304253(+) CTCTTG/AACTTC 1 -- ds50019Minor allele frequency- A:0.25NA WA CSA 135
rs713637761,2
C,F--48304301(+) ATTACC/AGGCAT 1 -- ds50012Minor allele frequency- A:0.50NA 4
rs1494254261,2
C--48304372(+) TATCAA/GTCTGC 1 -- ds50010--------

HapMap Linkage Disequilibrium report for TPRX1 (48304500 - 48322308 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for TPRX1:    About this table    
Variant IDTypeSubtypePubMed ID
dgv653e199CNV Deletion23128226
esv2718667CNV Deletion23290073
nsv912212CNV Gain21882294
nsv520073CNV Gain19592680
nsv458715CNV Gain19166990
nsv428367CNV Gain+Loss18775914

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611166    OMIM disorders: --


Find genes that share disorders with TPRX1           About GenesLikeMe


Export disorders for TPRX1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TPRX1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TPRX1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  2. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PubMed id 17005330)1 Booth H.A. and Holland P.W.H. (Gene 2007)
  3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 284355 HGNC: 32174 AceView: FLJ40321 Ensembl:ENSG00000178928 euGenes: HUgn284355
ECgene: TPRX1 H-InvDB: TPRX1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TPRX1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TPRX1 gene:
Search GeneIP for patents involving TPRX1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPRX1
 SwitchGear 3'UTR luciferase reporter plasmids for TPRX1
 SwitchGear Promoter luciferase reporter plasmids for TPRX1
 Search ThermoFisher Antibodies for TPRX1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPRX1
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TPRX1
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TPRX1
 LSBio Antibodies in human, mouse, rat for TPRX1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for TPRX1
  Search eBioscience for proteins for TPRX1
  Search eBioscience for elisas for TPRX1
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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