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Aliases for TPRX1 Gene

Aliases for TPRX1 Gene

  • Tetrapeptide Repeat Homeobox 1 2 3 5
  • Tetra-Peptide Repeat Homeobox Protein 1 3
  • Tetra-Peptide Repeat Homeobox 1 3
  • CRX Like Homeobox 2 3
  • TPRX 3

External Ids for TPRX1 Gene

Previous GeneCards Identifiers for TPRX1 Gene

  • GC19M052998
  • GC19M048304
  • GC19M044730

Summaries for TPRX1 Gene

Entrez Gene Summary for TPRX1 Gene

  • Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the TPRX homeobox gene family. [provided by RefSeq, Jul 2008]

GeneCards Summary for TPRX1 Gene

TPRX1 (Tetrapeptide Repeat Homeobox 1) is a Protein Coding gene. Among its related pathways are Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding.

Additional gene information for TPRX1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPRX1 Gene

Genomics for TPRX1 Gene

GeneHancer (GH) Regulatory Elements for TPRX1 Gene

Promoters and enhancers for TPRX1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I047819 Enhancer 0.5 ENCODE 550.8 -0.8 -836 0.8 SP1 GLIS1 IKZF1 IRF4 SPI1 TPRX1 GC19P047825 GC19P047824 GC19P047823 GC19P047822 GC19P047821 GC19P047820 CRX LINC01595 GC19P047839
GH19I047813 Enhancer 0.6 ENCODE 0.4 +5.2 5192 0.2 CTCF REST RAD21 ZNF148 ZBTB48 VEZF1 KLF9 SMC3 ZNF143 KLF8 TPRX1 RPL23AP80
GH19I047809 Enhancer 0.6 ENCODE 0.4 +9.2 9192 0.2 CEBPB RARA ZFHX2 EGR1 FOS KLF13 PRDM1 EGR2 SP7 ZNF18 TPRX1 RPL23AP80
GH19I047798 Enhancer 0.3 FANTOM5 0.3 +20.9 20899 0.2 CABP5 CRX SNORD23 NOP53 SULT2A1 RPL23AP80 TPRX1
GH19I047799 Enhancer 0.2 FANTOM5 0.4 +20.0 19961 0.2 CRX SNORD23 NOP53 SULT2A1 CABP5 RPL23AP80 TPRX1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TPRX1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TPRX1 gene promoter:

Genomic Locations for TPRX1 Gene

Genomic Locations for TPRX1 Gene
chr19:47,801,243-47,819,051
(GRCh38/hg38)
Size:
17,809 bases
Orientation:
Minus strand
chr19:48,304,500-48,322,308
(GRCh37/hg19)

Genomic View for TPRX1 Gene

Genes around TPRX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPRX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPRX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPRX1 Gene

Proteins for TPRX1 Gene

  • Protein details for TPRX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7U7-TPRX1_HUMAN
    Recommended name:
    Tetra-peptide repeat homeobox protein 1
    Protein Accession:
    Q8N7U7
    Secondary Accessions:
    • A5D8Y3
    • B2RPL5

    Protein attributes for TPRX1 Gene

    Size:
    411 amino acids
    Molecular mass:
    40603 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TPRX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPRX1 Gene

Post-translational modifications for TPRX1 Gene

No Post-translational modifications

Other Protein References for TPRX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TPRX1 Gene

Domains & Families for TPRX1 Gene

Gene Families for TPRX1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TPRX1 Gene

Suggested Antigen Peptide Sequences for TPRX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TPRX1: view

No data available for UniProtKB/Swiss-Prot for TPRX1 Gene

Function for TPRX1 Gene

Gene Ontology (GO) - Molecular Function for TPRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with TPRX1: view
genes like me logo Genes that share phenotypes with TPRX1: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TPRX1 Gene

Localization for TPRX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPRX1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPRX1 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for TPRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TPRX1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TPRX1 Gene

Pathways & Interactions for TPRX1 Gene

SuperPathways for TPRX1 Gene

SuperPathway Contained pathways
1 Preimplantation Embryo
genes like me logo Genes that share pathways with TPRX1: view

Pathways by source for TPRX1 Gene

1 BioSystems pathway for TPRX1 Gene

Interacting Proteins for TPRX1 Gene

Selected Interacting proteins: Q8N7U7-TPRX1_HUMAN for TPRX1 Gene via UniProtKB IID

Gene Ontology (GO) - Biological Process for TPRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TPRX1: view

No data available for SIGNOR curated interactions for TPRX1 Gene

Drugs & Compounds for TPRX1 Gene

No Compound Related Data Available

Transcripts for TPRX1 Gene

mRNA/cDNA for TPRX1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TPRX1 Gene

Tetra-peptide repeat homeobox 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPRX1 Gene

No ASD Table

Relevant External Links for TPRX1 Gene

GeneLoc Exon Structure for
TPRX1
ECgene alternative splicing isoforms for
TPRX1

Expression for TPRX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPRX1 Gene

mRNA differential expression in normal tissues according to GTEx for TPRX1 Gene

This gene is overexpressed in Testis (x42.2).

NURSA nuclear receptor signaling pathways regulating expression of TPRX1 Gene:

TPRX1

SOURCE GeneReport for Unigene cluster for TPRX1 Gene:

Hs.629812
genes like me logo Genes that share expression patterns with TPRX1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPRX1 Gene

Orthologs for TPRX1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TPRX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPRX1 34
  • 76 (a)
OneToOne
Species where no ortholog for TPRX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TPRX1 Gene

ENSEMBL:
Gene Tree for TPRX1 (if available)
TreeFam:
Gene Tree for TPRX1 (if available)

Paralogs for TPRX1 Gene

(6) SIMAP similar genes for TPRX1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for TPRX1 Gene

genes like me logo Genes that share paralogs with TPRX1: view

No data available for Paralogs for TPRX1 Gene

Variants for TPRX1 Gene

Sequence variations from dbSNP and Humsavar for TPRX1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000777598 -- 47,801,393(-) A/G 3_prime_UTR_variant
rs1000862751 -- 47,805,122(-) A/G upstream_transcript_variant
rs1001149556 -- 47,803,036(-) T/G intron_variant
rs1002481033 -- 47,804,329(-) A/C upstream_transcript_variant
rs1002815081 -- 47,803,099(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TPRX1 Gene

Variant ID Type Subtype PubMed ID
dgv653e199 CNV deletion 23128226
esv2718667 CNV deletion 23290073
esv3644559 CNV gain 21293372
esv3644564 CNV loss 21293372
nsv1058622 CNV gain 25217958
nsv1062085 CNV gain 25217958
nsv1066097 CNV gain 25217958
nsv1066782 CNV loss 25217958
nsv1071543 CNV deletion 25765185
nsv428367 CNV gain+loss 18775914
nsv458715 CNV gain 19166990
nsv520073 CNV gain 19592680
nsv579897 CNV gain 21841781

Variation tolerance for TPRX1 Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.48; 85.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPRX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TPRX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPRX1 Gene

Disorders for TPRX1 Gene

Additional Disease Information for TPRX1

No disorders were found for TPRX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPRX1 Gene

Publications for TPRX1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PMID: 17005330) Booth HA … Holland PW (Gene 2007) 3 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TPRX1 Gene

Sources for TPRX1 Gene

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