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Aliases for TPRX1 Gene

Aliases for TPRX1 Gene

  • Tetrapeptide Repeat Homeobox 1 2 3 5
  • Tetra-Peptide Repeat Homeobox Protein 1 3
  • Tetra-Peptide Repeat Homeobox 1 3
  • CRX Like Homeobox 2 3
  • TPRX 3

External Ids for TPRX1 Gene

Previous GeneCards Identifiers for TPRX1 Gene

  • GC19M052998
  • GC19M048304
  • GC19M044730

Summaries for TPRX1 Gene

Entrez Gene Summary for TPRX1 Gene

  • Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the TPRX homeobox gene family. [provided by RefSeq, Jul 2008]

GeneCards Summary for TPRX1 Gene

TPRX1 (Tetrapeptide Repeat Homeobox 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPRX1 Gene

Genomics for TPRX1 Gene

Regulatory Elements for TPRX1 Gene

Enhancers for TPRX1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F047741 0.4 ENCODE 12.5 +75.1 75130 5.0 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 ZC3H4 GLTSCR1 ENSG00000269321 GRWD1 SELENOW KDELR1 CCDC9 EHD2 TPRX2P ELSPBP1
GH19F047607 0.9 Ensembl ENCODE 12.4 +208.0 207965 6.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS ENSG00000269321 CCDC9 KDELR1 TPRX2P ELSPBP1 ZNF541 LOC105372430 GLTSCR2-AS1 ZC3H4 GRWD1
GH19F047104 0.2 ENCODE 12.4 +714.1 714058 0.8 PKNOX1 CREB3L1 SIN3A DMAP1 ZNF2 ZNF143 ZNF207 ZNF263 SP3 MXD4 CCDC9 TPRX2P ELSPBP1 GLTSCR2-AS1 ZC3H4 BSPH1 TPRX1 SLC1A5 ENSG00000268810 TMEM160
GH19F047239 0.9 FANTOM5 Ensembl ENCODE 12.4 +576.9 576851 6.4 CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF416 ZNF548 ZNF263 ZC3H4 GLTSCR1 ENSG00000268810 ENSG00000269321 CCDC9 GLTSCR2-AS1 EHD2 SLC1A5 PRKD2 TPRX2P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TPRX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TPRX1 Gene

47,801,243 bp from pter
47,819,051 bp from pter
17,809 bases
Minus strand

Genomic View for TPRX1 Gene

Genes around TPRX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPRX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPRX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPRX1 Gene

Proteins for TPRX1 Gene

  • Protein details for TPRX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetra-peptide repeat homeobox protein 1
    Protein Accession:
    Secondary Accessions:
    • A5D8Y3
    • B2RPL5

    Protein attributes for TPRX1 Gene

    411 amino acids
    Molecular mass:
    40603 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TPRX1 Gene


neXtProt entry for TPRX1 Gene

Post-translational modifications for TPRX1 Gene

No Post-translational modifications

Other Protein References for TPRX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TPRX1 Gene

Domains & Families for TPRX1 Gene

Gene Families for TPRX1 Gene

Protein Domains for TPRX1 Gene

Suggested Antigen Peptide Sequences for TPRX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with TPRX1: view

Function for TPRX1 Gene

Gene Ontology (GO) - Molecular Function for TPRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with TPRX1: view
genes like me logo Genes that share phenotypes with TPRX1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TPRX1 Gene

Localization for TPRX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPRX1 Gene

Subcellular locations from

Jensen Localization Image for TPRX1 Gene COMPARTMENTS Subcellular localization image for TPRX1 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for TPRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TPRX1: view

Pathways & Interactions for TPRX1 Gene

SuperPathways for TPRX1 Gene

No Data Available

Interacting Proteins for TPRX1 Gene

Selected Interacting proteins: Q8N7U7-TPRX1_HUMAN for TPRX1 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TPRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TPRX1: view

No data available for Pathways by source and SIGNOR curated interactions for TPRX1 Gene

Transcripts for TPRX1 Gene

mRNA/cDNA for TPRX1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TPRX1 Gene

Tetra-peptide repeat homeobox 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPRX1 Gene

No ASD Table

Relevant External Links for TPRX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPRX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TPRX1 Gene

mRNA differential expression in normal tissues according to GTEx for TPRX1 Gene

This gene is overexpressed in Testis (x42.2).

NURSA nuclear receptor signaling pathways regulating expression of TPRX1 Gene:


SOURCE GeneReport for Unigene cluster for TPRX1 Gene:

genes like me logo Genes that share expression patterns with TPRX1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TPRX1 Gene

Orthologs for TPRX1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TPRX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TPRX1 35
  • 76 (a)
Species where no ortholog for TPRX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TPRX1 Gene

Gene Tree for TPRX1 (if available)
Gene Tree for TPRX1 (if available)

Paralogs for TPRX1 Gene

(6) SIMAP similar genes for TPRX1 Gene using alignment to 3 proteins: Pseudogenes for TPRX1 Gene

genes like me logo Genes that share paralogs with TPRX1: view

No data available for Paralogs for TPRX1 Gene

Variants for TPRX1 Gene

Sequence variations from dbSNP and Humsavar for TPRX1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10420761 -- 47,804,591(+) CTTGG(C/T)TCTTA upstream-variant-2KB
rs111411093 -- 47,801,650(+) GAAGA(C/T)AGCAA utr-variant-3-prime
rs111902860 -- 47,800,989(+) TCTCA(A/G)ACTCT downstream-variant-500B
rs112397458 -- 47,802,393(+) GGGAT(C/T)GGGCC reference, synonymous-codon
rs112720019 -- 47,805,097(+) CCTAG(A/G)TGCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TPRX1 Gene

Variant ID Type Subtype PubMed ID
dgv653e199 CNV deletion 23128226
esv2718667 CNV deletion 23290073
esv3644559 CNV gain 21293372
esv3644564 CNV loss 21293372
nsv1058622 CNV gain 25217958
nsv1062085 CNV gain 25217958
nsv1066097 CNV gain 25217958
nsv1066782 CNV loss 25217958
nsv1071543 CNV deletion 25765185
nsv428367 CNV gain+loss 18775914
nsv458715 CNV gain 19166990
nsv520073 CNV gain 19592680
nsv579897 CNV gain 21841781

Variation tolerance for TPRX1 Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.48; 85.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPRX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPRX1 Gene

Disorders for TPRX1 Gene

Relevant External Links for TPRX1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TPRX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPRX1 Gene

Publications for TPRX1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PMID: 17005330) Booth H.A. … Holland P.W.H. (Gene 2007) 3 64
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TPRX1 Gene

Sources for TPRX1 Gene

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