Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TPRX1 Gene

Aliases for TPRX1 Gene

  • Tetra-Peptide Repeat Homeobox 1 2 3
  • Tetra-Peptide Repeat Homeobox Protein 1 3
  • CRX Like Homeobox 2 3
  • TPRX 3

External Ids for TPRX1 Gene

Previous GeneCards Identifiers for TPRX1 Gene

  • GC19M052998
  • GC19M048304
  • GC19M044730

Summaries for TPRX1 Gene

Entrez Gene Summary for TPRX1 Gene

  • Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the TPRX homeobox gene family. [provided by RefSeq, Jul 2008]

GeneCards Summary for TPRX1 Gene

TPRX1 (Tetra-Peptide Repeat Homeobox 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPRX1 Gene

Genomics for TPRX1 Gene

Regulatory Elements for TPRX1 Gene

Genomic Location for TPRX1 Gene

47,801,243 bp from pter
47,819,051 bp from pter
17,809 bases
Minus strand

Genomic View for TPRX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPRX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPRX1 Gene

Proteins for TPRX1 Gene

  • Protein details for TPRX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetra-peptide repeat homeobox protein 1
    Protein Accession:
    Secondary Accessions:
    • A5D8Y3
    • B2RPL5

    Protein attributes for TPRX1 Gene

    411 amino acids
    Molecular mass:
    40603 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TPRX1 Gene


neXtProt entry for TPRX1 Gene

Proteomics data for TPRX1 Gene at MOPED

Post-translational modifications for TPRX1 Gene

No Post-translational modifications

Other Protein References for TPRX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TPRX1 Gene

Domains for TPRX1 Gene

Gene Families for TPRX1 Gene

  • PRD :Homeoboxes / PRD class

Protein Domains for TPRX1 Gene


Suggested Antigen Peptide Sequences for TPRX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8N7U7
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with TPRX1: view

Function for TPRX1 Gene

Gene Ontology (GO) - Molecular Function for TPRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with TPRX1: view

Phenotypes for TPRX1 Gene

genes like me logo Genes that share phenotypes with TPRX1: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPRX1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TPRX1 Gene

Localization for TPRX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPRX1 Gene

Subcellular locations from

Jensen Localization Image for TPRX1 Gene COMPARTMENTS Subcellular localization image for TPRX1 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for TPRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TPRX1: view

Pathways for TPRX1 Gene

SuperPathways for TPRX1 Gene

No Data Available

Interacting Proteins for TPRX1 Gene

Gene Ontology (GO) - Biological Process for TPRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with TPRX1: view

No data available for Pathways by source for TPRX1 Gene

Transcripts for TPRX1 Gene

mRNA/cDNA for TPRX1 Gene

(5) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TPRX1 Gene

Tetra-peptide repeat homeobox 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPRX1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPRX1 Gene

No ASD Table

Relevant External Links for TPRX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPRX1 Gene

mRNA expression in normal human tissues for TPRX1 Gene

mRNA differential expression in normal tissues according to GTEx for TPRX1 Gene

This gene is overexpressed in Testis (42.2).

SOURCE GeneReport for Unigene cluster for TPRX1 Gene Hs.629812

genes like me logo Genes that share expressions with TPRX1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for TPRX1 Gene

Orthologs for TPRX1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TPRX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TPRX1 36
  • 76 (a)
Species with no ortholog for TPRX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TPRX1 Gene

Gene Tree for TPRX1 (if available)
Gene Tree for TPRX1 (if available)

Paralogs for TPRX1 Gene

Selected SIMAP similar genes for TPRX1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TPRX1: view

No data available for Paralogs for TPRX1 Gene

Variants for TPRX1 Gene

Sequence variations from dbSNP and Humsavar for TPRX1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1968238 -- 47,819,661(+) GCTTA(A/C)TTGAT upstream-variant-2KB
rs2910401 -- 47,804,646(-) GGAAA(C/G)GGAGG upstream-variant-2KB, intron-variant
rs2910402 -- 47,804,508(-) TGAGC(A/G)GGGAC upstream-variant-2KB, intron-variant
rs2932765 -- 47,804,636(+) CTGCC(A/G)GGACC upstream-variant-2KB, intron-variant
rs4047205 -- 47,804,428(+) AGGCC(C/T)AGCCC upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPRX1 Gene

Variant ID Type Subtype PubMed ID
nsv912212 CNV Gain 21882294
nsv520073 CNV Gain 19592680
nsv428367 CNV Gain+Loss 18775914
nsv458715 CNV Gain 19166990
dgv653e199 CNV Deletion 23128226
esv2718667 CNV Deletion 23290073

Relevant External Links for TPRX1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPRX1 Gene

Disorders for TPRX1 Gene

No disorders were found for TPRX1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TPRX1 Gene

Publications for TPRX1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PMID: 17005330) Booth H.A. … Holland P.W.H. (Gene 2007) 3
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TPRX1 Gene

Sources for TPRX1 Gene

Back to Top