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Aliases for TPRKB Gene

Aliases for TPRKB Gene

  • TP53RK Binding Protein 2 3
  • TP53RK-Binding Protein 3 4
  • PRPK-Binding Protein 3 4
  • PRPK (P53-Related Protein Kinase)-Binding Protein 3
  • CGI-121 3

External Ids for TPRKB Gene

Previous GeneCards Identifiers for TPRKB Gene

  • GC02M073869
  • GC02M073955

Summaries for TPRKB Gene

GeneCards Summary for TPRKB Gene

TPRKB (TP53RK Binding Protein) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA modification in the nucleus and cytosol. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for TPRKB Gene

  • Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPRKB Gene

Genomics for TPRKB Gene

Regulatory Elements for TPRKB Gene

Genomic Location for TPRKB Gene

Chromosome:
2
Start:
73,729,104 bp from pter
End:
73,740,104 bp from pter
Size:
11,001 bases
Orientation:
Minus strand

Genomic View for TPRKB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPRKB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPRKB Gene

Proteins for TPRKB Gene

  • Protein details for TPRKB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3C4-TPRKB_HUMAN
    Recommended name:
    EKC/KEOPS complex subunit TPRKB
    Protein Accession:
    Q9Y3C4
    Secondary Accessions:
    • D6W5H6
    • Q8IWR6
    • Q8IWR7
    • Q9H3K4

    Protein attributes for TPRKB Gene

    Size:
    175 amino acids
    Molecular mass:
    19661 Da
    Quaternary structure:
    • Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes. Interacts with TP53RK/PRPK.

    Three dimensional structures from OCA and Proteopedia for TPRKB Gene

    Alternative splice isoforms for TPRKB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPRKB Gene

Proteomics data for TPRKB Gene at MOPED

Post-translational modifications for TPRKB Gene

  • Ubiquitination at Lys 21
  • Modification sites at PhosphoSitePlus

Other Protein References for TPRKB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TPRKB Gene

Domains & Families for TPRKB Gene

Protein Domains for TPRKB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TPRKB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3C4

UniProtKB/Swiss-Prot:

TPRKB_HUMAN :
  • Belongs to the CGI121/TPRKB family.
Family:
  • Belongs to the CGI121/TPRKB family.
genes like me logo Genes that share domains with TPRKB: view

No data available for Gene Families for TPRKB Gene

Function for TPRKB Gene

Molecular function for TPRKB Gene

UniProtKB/Swiss-Prot Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (By similarity).

Gene Ontology (GO) - Molecular Function for TPRKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0019901 protein kinase binding IPI 12659830
genes like me logo Genes that share ontologies with TPRKB: view

Phenotypes for TPRKB Gene

GenomeRNAi human phenotypes for TPRKB:
genes like me logo Genes that share phenotypes with TPRKB: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPRKB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TPRKB Gene

Localization for TPRKB Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPRKB Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPRKB Gene COMPARTMENTS Subcellular localization image for TPRKB gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for TPRKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12659830
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IDA 12659830
genes like me logo Genes that share ontologies with TPRKB: view

Pathways & Interactions for TPRKB Gene

genes like me logo Genes that share pathways with TPRKB: view

Pathways by source for TPRKB Gene

Gene Ontology (GO) - Biological Process for TPRKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification TAS --
GO:0008033 tRNA processing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with TPRKB: view

No data available for SIGNOR curated interactions for TPRKB Gene

Drugs & Compounds for TPRKB Gene

No Compound Related Data Available

Transcripts for TPRKB Gene

Unigene Clusters for TPRKB Gene

TP53RK binding protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPRKB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPRKB Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: -
SP10: -
SP11: - - - - - -
SP12: - - - - - -
SP13:
SP14: - - - - - - - -
SP15: - - - -
SP16: - - -
SP17: - - -
SP18: - - - - -

Relevant External Links for TPRKB Gene

GeneLoc Exon Structure for
TPRKB
ECgene alternative splicing isoforms for
TPRKB

Expression for TPRKB Gene

mRNA expression in normal human tissues for TPRKB Gene

Protein differential expression in normal tissues from HIPED for TPRKB Gene

This gene is overexpressed in NK cells (6.2) and Spleen (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPRKB Gene



SOURCE GeneReport for Unigene cluster for TPRKB Gene Hs.157401

mRNA Expression by UniProt/SwissProt for TPRKB Gene

Q9Y3C4-TPRKB_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with TPRKB: view

Protein tissue co-expression partners for TPRKB Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TPRKB Gene

Orthologs for TPRKB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TPRKB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TPRKB 35
  • 91.81 (n)
  • 90.86 (a)
TPRKB 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPRKB 35
  • 92.57 (n)
  • 94.86 (a)
TPRKB 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tprkb 35
  • 86.1 (n)
  • 85.14 (a)
Tprkb 16
Tprkb 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TPRKB 35
  • 99.55 (n)
  • 99.32 (a)
TPRKB 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tprkb 35
  • 86.86 (n)
  • 83.43 (a)
oppossum
(Monodelphis domestica)
Mammalia TPRKB 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TPRKB 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves TPRKB 35
  • 73.56 (n)
  • 69.54 (a)
TPRKB 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TPRKB 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75657 35
tprkb 35
  • 71.1 (n)
  • 61.85 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53277 35
zebrafish
(Danio rerio)
Actinopterygii tprkb 35
  • 64.94 (n)
  • 56.9 (a)
tprkb 36
  • 57 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1574 35
worm
(Caenorhabditis elegans)
Secernentea W03F8.4 35
  • 48.84 (n)
  • 36.63 (a)
W03F8.4 36
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CGI121 36
  • 29 (a)
OneToOne
CGI121 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G34412 35
  • 46.67 (n)
  • 34.84 (a)
rice
(Oryza sativa)
Liliopsida Os01g0142200 35
  • 47.47 (n)
  • 36.71 (a)
Species with no ortholog for TPRKB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPRKB Gene

ENSEMBL:
Gene Tree for TPRKB (if available)
TreeFam:
Gene Tree for TPRKB (if available)

Paralogs for TPRKB Gene

Pseudogenes.org Pseudogenes for TPRKB Gene

genes like me logo Genes that share paralogs with TPRKB: view

No data available for Paralogs for TPRKB Gene

Variants for TPRKB Gene

Sequence variations from dbSNP and Humsavar for TPRKB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7210 -- 73,729,997(-) AGTAT(C/G/T)GGGAC synonymous-codon, missense, reference
rs1046114 -- 73,729,917(-) AAATT(C/G/T)TCAGC utr-variant-3-prime
rs2421556 -- 73,733,254(-) AAAAA(A/C)AAAAA intron-variant
rs2421676 -- 73,738,960(-) tctcc(C/T)agaaa upstream-variant-2KB, intron-variant
rs2421677 -- 73,738,790(-) gatca(A/C)gtgat upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPRKB Gene

Variant ID Type Subtype PubMed ID
dgv1197e1 CNV Complex 17122850
essv105 CNV CNV 17122850
nsv874276 CNV Loss 21882294
nsv834260 CNV Gain 17160897

Variation tolerance for TPRKB Gene

Residual Variation Intolerance Score: 57.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPRKB Gene

HapMap Linkage Disequilibrium report
TPRKB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPRKB Gene

Disorders for TPRKB Gene

Relevant External Links for TPRKB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPRKB
genes like me logo Genes that share disorders with TPRKB: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPRKB Gene

Publications for TPRKB Gene

  1. A Small Ras-like protein Ray/Rab1c modulates the p53-regulating activity of PRPK. (PMID: 16600182) Abe Y. … Kito K. (Biochem. Biophys. Res. Commun. 2006) 23 67
  2. Identification of CGI-121, a novel PRPK (p53-related protein kinase)- binding protein. (PMID: 12659830) Miyoshi A. … Ueda N. (Biochem. Biophys. Res. Commun. 2003) 2 67
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for TPRKB Gene

Sources for TPRKB Gene

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