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TPRKB Gene

protein-coding   GIFtS: 52
GCID: GC02M073955

TP53RK Binding Protein

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
TP53RK Binding Protein1 2
PRPK-Binding Protein2 3
TP53RK-Binding Protein2 3
EKC/KEOPS Complex Subunit TPRKB2
PRPK (P53-Related Protein Kinase)-Binding Protein2

External Ids:    HGNC: 242591   Entrez Gene: 510022   Ensembl: ENSG000001440347   OMIM: 6086805   UniProtKB: Q9Y3C43   
ORGUL members:         

Export aliases for TPRKB gene to outside databases

Previous GC identifers: GC02M073869 GC02M073691


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TPRKB Gene:
TPRKB (TP53RK binding protein) is a protein-coding gene. Diseases associated with TPRKB include kidney disease. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot: TPRKB_HUMAN, Q9Y3C4
Function: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on
adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably
involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of
A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required
for tRNA modification (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TPRKB gene promoter:
         Nkx3-1 v4   GATA-3   FOXO3   GATA-1   GATA-2   FOXO3b   FOXC1   HFH-1   FOXO3a   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTPRKB promoter sequence
   Search Chromatin IP Primers for TPRKB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPRKB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24.3-p24.1   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p24.3-p24.1

TPRKB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPRKB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M073955:  view genomic region     (about GC identifiers)

Start:
73,956,231 bp from pter      End:
73,964,527 bp from pter
Size:
8,297 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TPRKB_HUMAN, Q9Y3C4 (See protein sequence)
Recommended Name: EKC/KEOPS complex subunit TPRKB  
Size: 175 amino acids; 19661 Da
Subunit: Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex
dimerizes. Interacts with TP53RK/PRPK
1 PDB 3D structure from and Proteopedia for TPRKB:
3ENP (3D)    
Secondary accessions: D6W5H6 Q8IWR6 Q8IWR7 Q9H3K4
Alternative splicing: 3 isoforms:  Q9Y3C4-1   Q9Y3C4-2   Q9Y3C4-3   

Explore the universe of human proteins at neXtProt for TPRKB: NX_Q9Y3C4

Explore proteomics data for TPRKB at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys21
  • Modification sites at PhosphoSitePlus

  • See TPRKB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057142.1  
    ENSEMBL proteins: 
     ENSP00000272424   ENSP00000386936   ENSP00000325398  

    TPRKB Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR013926 CGI121/TPRKB

    Graphical View of Domain Structure for InterPro Entry Q9Y3C4

    ProtoNet protein and cluster: Q9Y3C4

    UniProtKB/Swiss-Prot: TPRKB_HUMAN, Q9Y3C4
    Similarity: Belongs to the CGI121/TPRKB family


    TPRKB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TPRKB_HUMAN, Q9Y3C4
    Function: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on
    adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably
    involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of
    A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required
    for tRNA modification (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0019901protein kinase binding IPI12659830
         
    TPRKB for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target TPRKB:
    hsa-mir-26b-5p (MIRT029846), hsa-mir-877-3p (MIRT036857), hsa-mir-155-5p (MIRT020915)

    Block miRNA regulation of human, mouse, rat TPRKB using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TPRKB_HUMAN, Q9Y3C4: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12659830
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IDA12659830

    TPRKB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TPRKB
    Interactions:

        Search GeneGlobe Interaction Network for TPRKB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for TPRKB (Q9Y3C41, 2, 3 ENSP000002724244) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53RKQ96S441, 3, ENSP000003611864EBI-750123,EBI-739588 I2D: score=3 STRING: ENSP00000361186
    RAD52P433513, ENSP000003512844I2D: score=1 STRING: ENSP00000351284
    NDEL1Q9GZM83I2D: score=1 
    NR2F1P105893I2D: score=1 
    TSC22D4Q9Y3Q83I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008033tRNA processing IEA--
    GO:0030163protein catabolic process NAS12659830

    TPRKB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TPRKB



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TPRKB gene: 
    NM_016058.2  

    Unigene Cluster for TPRKB:

    TP53RK binding protein
    Hs.157401  [show with all ESTs]
    Unigene Representative Sequence: AK097254
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489476 ENST00000463231 ENST00000484969 ENST00000272424(uc002sjl.2 uc002sjn.2 uc002sjo.2)
    ENST00000485758 ENST00000409716(uc002sjm.2) ENST00000318190(uc010yrm.1)
    ENST00000497464 ENST00000462166 ENST00000470012
    miRNA
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    hsa-miR-155
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    Additional mRNA sequence: 

    AF060921.1 AF151879.1 AK097254.1 AK291071.1 AK295239.1 AY157986.1 AY157987.1 AY643713.1 
    BC029492.1 

    11 DOTS entries:

    DT.97864750  DT.444970  DT.100045746  DT.100045745  DT.95202625  DT.100691844  DT.100740759  DT.100691853 
    DT.100778417  DT.100833962  DT.75188310 

    Selected AceView cDNA sequences (see all 146):

    BQ011099 AK097254 BG501962 AI913556 CD724253 AW271404 AY157987 AI934393 
    BM801562 AI199816 AA300221 AI161087 AY157986 AI262165 AI499185 AI762341 
    BM542190 AI356452 AW195464 AW052169 BG722965 BE550240 CA867170 AI263061 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TPRKB (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d ^ 9
    SP1:                                -                                         -     -     -                       -     -                                 
    SP2:                                -                                         -     -     -                                                               
    SP3:                                -                       -     -           -     -     -                       -     -                                 
    SP4:                                -                       -     -           -     -     -                       -     -     -     -     -     -         
    SP5:                                -                       -     -           -     -     -                       -     -                                 


    ECgene alternative splicing isoforms for TPRKB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TPRKB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGGCACCA
    TPRKB Expression
    About this image

    TPRKB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TPRKB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.157401

    UniProtKB/Swiss-Prot: TPRKB_HUMAN, Q9Y3C4
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TPRKB gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tprkb1 , 5 Tp53rk binding protein1, 5 86.1(n)1
    85.14(a)1
      6 (37.53 cM)5
    697861  NM_001170488.11  NP_001163959.11 
     859157385 
    chicken
    (Gallus gallus)
    Aves TPRKB1 TP53RK binding protein 73.56(n)
    69.54(a)
      425906  XM_423597.4  XP_423597.2 
    lizard
    (Anolis carolinensis)
    Reptilia TPRKB6
    TP53RK binding protein
    68(a)
    1 ↔ 1
    5(99342254-99350976)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC532772 hypothetical protein MGC53277 75.4(n)    BC045235.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tprkb1 Tp53rk binding protein 64.94(n)
    56.9(a)
      492501  NM_001007373.1  NP_001007374.1 
    worm
    (Caenorhabditis elegans)
    Secernentea W03F8.41 W03F8.4 48.84(n)
    36.63(a)
      177293  NM_068334.3  NP_500735.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CGI121(YML036W)4 Component of the EKC/KEOPS complex with Bud32p, Kae1p, more   --   13(205642-206293) 854972  NP_013676.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G344121 AT4G34412 46.67(n)
    34.84(a)
      829592  NM_148397.2  NP_680763.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g01422001 Os01g0142200 47.47(n)
    36.71(a)
      4325487  NM_001048525.1  NP_001041990.1 


    ENSEMBL Gene Tree for TPRKB (if available)
    TreeFam Gene Tree for TPRKB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TPRKB gene

    TPRKB for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TPRKB
    PGOHUM00000238706 PGOHUM00000248771


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TPRKB (see all 222)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446369651,2
    --73956584(+) GTAACC/TGATTA 1 -- ds50010--------
    rs1149398221,2
    C,F--73956588(+) CTGATG/TATCTT 1 -- ds50010--------
    rs2021588391,2
    C--73956647(+) TTTTTG/TGTTTT 1 -- ds50010--------
    rs61468091,2
    C--73956659(+) TTTTT-/TTGGTT
    TTTTTTTTT
    GAGAC
    2 -- ds5001 cds11Minor allele frequency- TTGGTTTTTTTTTTT:0.00NA 2
    rs130205171,2
    C--73956744(+) TCATGT/CGATTC 1 -- ds50015Minor allele frequency- C:0.10NA CSA 10
    rs1492839441,2
    --73956798(+) CATCAC/TGCCCA 1 -- ds50010--------
    rs127137941,2
    C,F--73956846(+) ATGTTG/AGCCAG 1 -- ds50016Minor allele frequency- A:0.18NA WA CSA 11
    rs129975681,2
    C--73956881(+) GGTGAC/TCCACC 1 -- ds50015Minor allele frequency- T:0.10NA CSA 10
    rs1902782291,2
    --73956931(+) CCACCA/GTGCCT 1 -- ds50010--------
    rs678051621,2
    C--73956941(+) TGGCC-/TTTTTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TPRKB (73956231 - 73964527 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TPRKB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv874276CNV Loss21882294
    nsv834260CNV Gain17160897
    essv105CNV CNV17122850
    dgv1197e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608680    OMIM disorders: --

    1 disease for TPRKB:    
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    kidney disease


    TPRKB for disorders           About GeneDecksing


    Export disorders for TPRKB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TPRKB gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with TPRKB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of CGI-121, a novel PRPK (p53-related protein kinase)- binding protein. (PubMed id 12659830)1, 2, 3 Miyoshi A.... Ueda N. (Biochem. Biophys. Res. Commun. 2003)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    3. The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME. (PubMed id 22912744)1, 2 Costessi A....Stunnenberg H.G. (PLoS ONE 2012)
    4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    8. A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection. (PubMed id 21931564)1 Nicholson G....Holmes C.C. (PLoS Genet. 2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51002 HGNC: 24259 AceView: CGI-121 Ensembl:ENSG00000144034 euGenes: HUgn51002
    ECgene: TPRKB H-InvDB: TPRKB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TPRKB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TPRKB gene:
    Search GeneIP for patents involving TPRKB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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