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Aliases for TPRKB Gene

Aliases for TPRKB Gene

  • TP53RK Binding Protein 2 3 5
  • PRPK (P53-Related Protein Kinase)-Binding Protein 3
  • EKC/KEOPS Complex Subunit TPRKB 3
  • TP53RK-Binding Protein 4
  • PRPK-Binding Protein 4
  • CGI-121 3
  • CGI121 3

External Ids for TPRKB Gene

Previous GeneCards Identifiers for TPRKB Gene

  • GC02M073869
  • GC02M073955

Summaries for TPRKB Gene

GeneCards Summary for TPRKB Gene

TPRKB (TP53RK Binding Protein) is a Protein Coding gene. Among its related pathways are tRNA processing and Gene Expression. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for TPRKB Gene

  • Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPRKB Gene

Genomics for TPRKB Gene

Regulatory Elements for TPRKB Gene

Enhancers for TPRKB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F073716 0.7 Ensembl ENCODE 23.1 +23.0 23004 1.8 BCOR IRF2 ATF1 PKNOX1 CBX3 ZMYM3 NFYB FOS CREM SRF TPRKB ALMS1P1 NAT8B
GH02F073699 1.2 Ensembl ENCODE 21.4 +38.9 38888 3.9 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 TPRKB SMYD5 ENSG00000272702 DUSP11 SEMA4F NAT8B ALMS1P1
GH02F073703 0.7 Ensembl 21.4 +35.8 35804 1.0 CTCF MNT SPI1 TPRKB ALMS1P1 NAT8 NAT8B
GH02F073776 1.3 Ensembl ENCODE 12.1 -37.2 -37178 1.2 PKNOX1 INSM2 KLF17 ZEB1 ZNF121 ZNF366 SCRT2 FOS EGR2 ZNF362 ALMS1P1 TPRKB BOLA3 BOLA3-AS1 DUSP11 ENSG00000280037
GH02F073736 0.4 ENCODE 11.3 +2.9 2888 2.2 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF207 ZNF263 DUSP11 SEMA4F SMYD5 C2orf81 ENSG00000273245 TPRKB DCTN1 PCGF1 FBXO41 NAT8B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TPRKB on UCSC Golden Path with GeneCards custom track

Genomic Location for TPRKB Gene

Chromosome:
2
Start:
73,729,104 bp from pter
End:
73,740,104 bp from pter
Size:
11,001 bases
Orientation:
Minus strand

Genomic View for TPRKB Gene

Genes around TPRKB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPRKB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPRKB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPRKB Gene

Proteins for TPRKB Gene

  • Protein details for TPRKB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3C4-TPRKB_HUMAN
    Recommended name:
    EKC/KEOPS complex subunit TPRKB
    Protein Accession:
    Q9Y3C4
    Secondary Accessions:
    • D6W5H6
    • Q8IWR6
    • Q8IWR7
    • Q9H3K4

    Protein attributes for TPRKB Gene

    Size:
    175 amino acids
    Molecular mass:
    19661 Da
    Quaternary structure:
    • Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes. Interacts with TP53RK/PRPK.

    Three dimensional structures from OCA and Proteopedia for TPRKB Gene

    Alternative splice isoforms for TPRKB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPRKB Gene

Post-translational modifications for TPRKB Gene

  • Ubiquitination at Lys 21
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TPRKB Gene

Domains & Families for TPRKB Gene

Protein Domains for TPRKB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TPRKB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3C4

UniProtKB/Swiss-Prot:

TPRKB_HUMAN :
  • Belongs to the CGI121/TPRKB family.
Family:
  • Belongs to the CGI121/TPRKB family.
genes like me logo Genes that share domains with TPRKB: view

No data available for Gene Families for TPRKB Gene

Function for TPRKB Gene

Molecular function for TPRKB Gene

UniProtKB/Swiss-Prot Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (By similarity).

Gene Ontology (GO) - Molecular Function for TPRKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0019901 protein kinase binding IPI 12659830
genes like me logo Genes that share ontologies with TPRKB: view

Phenotypes for TPRKB Gene

genes like me logo Genes that share phenotypes with TPRKB: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPRKB Gene

Localization for TPRKB Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPRKB Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPRKB Gene COMPARTMENTS Subcellular localization image for TPRKB gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TPRKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12659830
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IDA 12659830
genes like me logo Genes that share ontologies with TPRKB: view

Pathways & Interactions for TPRKB Gene

genes like me logo Genes that share pathways with TPRKB: view

Pathways by source for TPRKB Gene

Gene Ontology (GO) - Biological Process for TPRKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
genes like me logo Genes that share ontologies with TPRKB: view

No data available for SIGNOR curated interactions for TPRKB Gene

Transcripts for TPRKB Gene

Unigene Clusters for TPRKB Gene

TP53RK binding protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPRKB Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: -
SP10: -
SP11: - - - - - -
SP12: - - - - - -
SP13:
SP14: - - - - - - - -
SP15: - - - -
SP16: - - -
SP17: - - -
SP18: - - - - -

Relevant External Links for TPRKB Gene

GeneLoc Exon Structure for
TPRKB
ECgene alternative splicing isoforms for
TPRKB

Expression for TPRKB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TPRKB Gene

Protein differential expression in normal tissues from HIPED for TPRKB Gene

This gene is overexpressed in NK cells (6.2) and Spleen (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TPRKB Gene



Protein tissue co-expression partners for TPRKB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TPRKB Gene:

TPRKB

SOURCE GeneReport for Unigene cluster for TPRKB Gene:

Hs.157401

mRNA Expression by UniProt/SwissProt for TPRKB Gene:

Q9Y3C4-TPRKB_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with TPRKB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TPRKB Gene

Orthologs for TPRKB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TPRKB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPRKB 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia TPRKB 34 35
  • 92.57 (n)
cow
(Bos Taurus)
Mammalia TPRKB 34 35
  • 91.81 (n)
rat
(Rattus norvegicus)
Mammalia Tprkb 34
  • 86.86 (n)
mouse
(Mus musculus)
Mammalia Tprkb 34 16 35
  • 86.1 (n)
oppossum
(Monodelphis domestica)
Mammalia TPRKB 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TPRKB 35
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves TPRKB 34 35
  • 73.56 (n)
lizard
(Anolis carolinensis)
Reptilia TPRKB 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tprkb 34
  • 71.1 (n)
MGC75657 34
African clawed frog
(Xenopus laevis)
Amphibia MGC53277 34
zebrafish
(Danio rerio)
Actinopterygii tprkb 34 35
  • 64.94 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1574 34
worm
(Caenorhabditis elegans)
Secernentea W03F8.4 34 35
  • 48.84 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CGI121 35 37
  • 29 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G34412 34
  • 46.67 (n)
rice
(Oryza sativa)
Liliopsida Os01g0142200 34
  • 47.47 (n)
Species where no ortholog for TPRKB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPRKB Gene

ENSEMBL:
Gene Tree for TPRKB (if available)
TreeFam:
Gene Tree for TPRKB (if available)

Paralogs for TPRKB Gene

Pseudogenes.org Pseudogenes for TPRKB Gene

genes like me logo Genes that share paralogs with TPRKB: view

No data available for Paralogs for TPRKB Gene

Variants for TPRKB Gene

Sequence variations from dbSNP and Humsavar for TPRKB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1046114 -- 73,729,917(-) AAATT(C/G/T)TCAGC utr-variant-3-prime
rs111270935 -- 73,734,864(+) GCTGC(C/T)TCCCC intron-variant
rs111347969 -- 73,731,098(+) GTGCT(C/G)AAGCT intron-variant
rs111699922 -- 73,734,591(+) ATTCT(A/T)CTGCA intron-variant, utr-variant-5-prime
rs111787423 -- 73,730,677(+) ATGTA(A/G)ACAAT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TPRKB Gene

Variant ID Type Subtype PubMed ID
dgv3870n100 CNV gain 25217958
esv2759060 CNV gain 17122850
nsv1003153 CNV loss 25217958
nsv834260 CNV gain 17160897

Variation tolerance for TPRKB Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPRKB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TPRKB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPRKB Gene

Disorders for TPRKB Gene

Relevant External Links for TPRKB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPRKB

No disorders were found for TPRKB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPRKB Gene

Publications for TPRKB Gene

  1. Identification of CGI-121, a novel PRPK (p53-related protein kinase)- binding protein. (PMID: 12659830) Miyoshi A. … Ueda N. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 64
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  3. The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME. (PMID: 22912744) Costessi A. … Stunnenberg H.G. (PLoS ONE 2012) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for TPRKB Gene

Sources for TPRKB Gene

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