TPRKB Gene
protein-coding GIFtS: 49
GCID: GC02M073955
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TP53RK binding protein
| |
Aliases
for TPRKB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TP53RK Binding Protein1 2 | | PRPK-Binding Protein2 3 | | CGI-1211 | | PRPK (P53-Related Protein Kinase)-Binding Protein2 | | TP53RK-Binding Protein2 |
Export aliases for TPRKB gene to outside databasesPrevious GC identifers: GC02M073869 GC02M073691 |
Summaries
for TPRKB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TPRKB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TPRKB gene promoter:
Nkx3-1 v4 GATA-3 FOXO3 GATA-1 GATA-2 FOXO3b FOXC1 HFH-1 FOXO3a Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for TPRKB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPRKB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p24.3-p24.1 Ensembl cytogenetic band: 2p13.1 HGNC cytogenetic band: 2p24.3-p24.1TPRKB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M073955: view genomic region
(about GC identifiers)
Start:
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73,956,231 bp from pter |
End:
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73,964,527 bp from pter |
Size:
|
8,297 bases |
Orientation:
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minus strand |
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Proteins
for TPRKB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TPRKB_HUMAN, Q9Y3C4 (See
protein sequence)Recommended Name: TP53RK-binding protein Size: 175 amino acids; 19661 Da
Subunit: Interacts with TP53RK/PRPK
Subcellular location: Cytoplasm. Nucleus
1 PDB 3D structure from  and Proteopedia  for TPRKB:3ENP (3D)
Secondary accessions: D6W5H6 Q8IWR6 Q8IWR7 Q9H3K4Alternative splicing: 3 isoforms: Q9Y3C4-1 Q9Y3C4-2 Q9Y3C4-3 Explore the universe of human proteins at neXtProt for TPRKB: NX_Q9Y3C4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y3C4
TPRKB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057142.1
ENSEMBL proteins: ENSP00000272424 ENSP00000386936 ENSP00000325398
Human Recombinant Protein Products for TPRKB:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TPRKB for ontologies About GeneDecksing
TPRKB Antibody Products:
Assay Products for TPRKB: |
Protein
Domains /
Families
for TPRKB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TPRKB for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y3C4ProtoNet protein and cluster: Q9Y3C4 UniProtKB/Swiss-Prot: TPRKB_HUMAN, Q9Y3C4Similarity: Belongs to the CGI121/TPRKB family |
Function
for TPRKB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
TPRKB for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPRKB (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPRKB (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TPRKB (NM_016058) | |  | Sino Biological Human cDNA Clone for TPRKB | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TPRKB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPRKB |
|
Pathways & Interactions
for TPRKB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TPRKB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/11 Interacting proteins for TPRKB (Q9Y3C42, 3 ENSP000002724244) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
TPRKB for ontologies About GeneDecksing
|
Drugs & Compounds
for TPRKB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TPRKB
Search CenterWatch for drugs/clinical trials and news about TPRKB
|
Transcripts
for TPRKB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TPRKB gene: NM_016058.2 Unigene Cluster for TPRKB: TP53RK binding protein Hs.157401 [show with all ESTs]Unigene Representative Sequence: AK09725410 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000489476 ENST00000463231 ENST00000484969 ENST00000272424(uc002sjl.2 uc002sjn.2 uc002sjo.2)
ENST00000485758 ENST00000409716(uc002sjm.2) ENST00000318190(uc010yrm.1)
ENST00000497464 ENST00000462166 ENST00000470012
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPRKB (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPRKB (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TPRKB (NM_016058) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TPRKB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPRKB |
Additional cDNA sequence: AF060921.1 AF151879.1 AK097254.1 AK291071.1 AK295239.1 AY157986.1 AY157987.1 AY643713.1 BC029492.1 11 DOTS entries: DT.97864750 DT.444970 DT.100045746 DT.100045745 DT.95202625 DT.100691844 DT.100740759 DT.100691853 DT.100778417 DT.100833962 DT.75188310 24/146 AceView cDNA sequences (see all 146): AW271404 BM801562 AI262165 BQ011099 BG501962 AI934393 AY157987 AI161087 AI913556 AA300221 AK097254 CD724253 AI199816 AY157986 AF151879 AI640247 CD696897 N88290 CD511908 BQ428673 BE621096 BU933187 BI562473 BI465043
GeneLoc Exon Structure
5/18 Alternative Splicing Database (ASD) splice patterns (SP) for TPRKB (see all 18) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 |
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| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | - | | - | | - | | | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | - | | - | | | | - | | - | | - | | | | | | | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | - | | - | | | | - | | - | | - | | | | | | | | - | | - | | - | | - | | - | | - | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | - | | - | | | | - | | - | | - | | | | | | | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for TPRKB
|
Expression
for TPRKB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TPRKB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGGCACCA
About this image
See TPRKB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TPRKB
SOURCE GeneReport for Unigene cluster: Hs.157401
UniProtKB/Swiss-Prot: TPRKB_HUMAN, Q9Y3C4Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for TPRKB
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TPRKB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TPRKB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPRKB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPRKB |
Orthologs
for TPRKB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TPRKB gene from 9/25 species (see all 25) About this table
ENSEMBL Gene Tree for TPRKB (if available)
TreeFam Gene Tree for TPRKB (if available) |
Paralogs
for TPRKB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TPRKB gene
TPRKB for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for TPRKB
PGOHUM00000238706 PGOHUM00000248771
|
Genomic Variants
for TPRKB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TPRKB (73956231 - 73964527 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TPRKB
1 CNV: 3365 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPRKB |
|
Disorders
/ Diseases
for TPRKB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TPRKB for disorders About GeneDecksing
OMIM gene information: 608680
OMIM disorders: --
1  disease for TPRKB: About MalaCardskidney disease
Export disorders for TPRKB gene to outside databases
|
Publications
for TPRKB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TPRKB gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with TPRKB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of CGI-121, a novel PRPK (p53-related protein kinase)- binding protein. (PubMed id 12659830)1, 2, 3 Miyoshi A.... Ueda N. (2003)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
- The human EKC/KEOPS complex is recruited to Cullin2 ub iquitin ligases by the human tumour antigen PRAME. (PubMed id 22912744)1 Costessi A....Stunnenberg H.G. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- A genome-wide metabolic QTL analysis in Europeans impl icates two loci shaped by recent positive selection. (PubMed id 21931564)1 Nicholson G....Holmes C.C. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Genetic loci influencing kidney function and chronic kidney disease. (PubMed id 20383145)1 Chambers J.C....Kooner J.S. (2010)
|
External Searches for TPRKB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TPRKB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TPRKB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TPRKB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TPRKB | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TPRKB gene:
Search GeneIP for patents involving TPRKB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TPRKB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for TPRKB | | OriGene shRNA RFP for TPRKB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TPRKB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TPRKB | | | OriGene Protein Over-expression Lysate for TPRKB | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TPRKB | | OriGene 3'-UTR Clone for TPRKB | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPRKB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPRKB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TPRKB | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TPRKB | | OriGene Custom Protein Services for TPRKB | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TPRKB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPRKB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPRKB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TPRKB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPRKB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPRKB |
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| | | | Search Tocris compounds for TPRKB |
| |  |  |  |  | | | | | | Recombinant Protein for TPRKB |
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 | | | TPRKB Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | ThermoFisher Antibodies for TPRKB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPRKB |
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