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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TPRKB Gene

protein-coding   GIFtS: 50
GCID: GC02M073955

TP53RK Binding Protein

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TP53RK Binding Protein1 2
PRPK-Binding Protein2 3
PRPK (P53-Related Protein Kinase)-Binding Protein2
TP53RK-Binding Protein2

External Ids:    HGNC: 242591   Entrez Gene: 510022   Ensembl: ENSG000001440347   OMIM: 6086805   UniProtKB: Q9Y3C43   

Export aliases for TPRKB gene to outside databases

Previous GC identifers: GC02M073869 GC02M073691


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TPRKB Gene: 
TPRKB (TP53RK binding protein) is a protein-coding gene. Diseases associated with TPRKB include kidney disease. GO annotations related to this gene include protein kinase binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TPRKB gene promoter:
         Nkx3-1 v4   GATA-3   FOXO3   GATA-1   GATA-2   FOXO3b   FOXC1   HFH-1   FOXO3a   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTPRKB promoter sequence
   Search SABiosciences Chromatin IP Primers for TPRKB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPRKB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24.3-p24.1   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p24.3-p24.1

TPRKB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPRKB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M073955:  view genomic region     (about GC identifiers)

Start:
73,956,231 bp from pter      End:
73,964,527 bp from pter
Size:
8,297 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TPRKB_HUMAN, Q9Y3C4 (See protein sequence)
Recommended Name: TP53RK-binding protein  
Size: 175 amino acids; 19661 Da
Subunit: Interacts with TP53RK/PRPK
Subcellular location: Cytoplasm. Nucleus
1 PDB 3D structure from and Proteopedia for TPRKB:
3ENP (3D)    
Secondary accessions: D6W5H6 Q8IWR6 Q8IWR7 Q9H3K4
Alternative splicing: 3 isoforms:  Q9Y3C4-1   Q9Y3C4-2   Q9Y3C4-3   

Explore the universe of human proteins at neXtProt for TPRKB: NX_Q9Y3C4

Explore proteomics data for TPRKB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y3C4

  • TPRKB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TPRKB Protein Expression
    REFSEQ proteins: NP_057142.1  
    ENSEMBL proteins: 
     ENSP00000272424   ENSP00000386936   ENSP00000325398  

    Human Recombinant Protein Products for TPRKB: 
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    Novus Biologicals TPRKB Proteins
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TPRKB
    Cloud-Clone Corp. Proteins for TPRKB 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12659830
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IDA12659830

    TPRKB for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for TPRKB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR013926 CGI121/TPRKB

    Graphical View of Domain Structure for InterPro Entry Q9Y3C4

    ProtoNet protein and cluster: Q9Y3C4

    UniProtKB/Swiss-Prot: TPRKB_HUMAN, Q9Y3C4
    Similarity: Belongs to the CGI121/TPRKB family


    TPRKB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0019901protein kinase binding IPI12659830
         
    TPRKB for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TPRKB 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TPRKB 
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    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate TPRKB:
    hsa-miR-155
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPRKB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TPRKB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/11 Interacting proteins for TPRKB (Q9Y3C41, 2, 3 ENSP000002724244) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53RKQ96S441, 3, ENSP000003611864EBI-750123,EBI-739588 I2D: score=3 STRING: ENSP00000361186
    RAD52P433513, ENSP000003512844I2D: score=1 STRING: ENSP00000351284
    NDEL1Q9GZM83I2D: score=1 
    NR2F1P105893I2D: score=1 
    TSC22D4Q9Y3Q83I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030163protein catabolic process NAS12659830

    TPRKB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TPRKB

    Search CenterWatch for drugs/clinical trials and news about TPRKB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TPRKB gene: 
    NM_016058.2  

    Unigene Cluster for TPRKB:

    TP53RK binding protein
    Hs.157401  [show with all ESTs]
    Unigene Representative Sequence: AK097254
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489476 ENST00000463231 ENST00000484969 ENST00000272424(uc002sjl.2 uc002sjn.2 uc002sjo.2)
    ENST00000485758 ENST00000409716(uc002sjm.2) ENST00000318190(uc010yrm.1)
    ENST00000497464 ENST00000462166 ENST00000470012
    miRNA
    Products:
         
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate TPRKB:
    hsa-miR-155
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF060921.1 AF151879.1 AK097254.1 AK291071.1 AK295239.1 AY157986.1 AY157987.1 AY643713.1 
    BC029492.1 

    11 DOTS entries:

    DT.97864750  DT.444970  DT.100045746  DT.100045745  DT.95202625  DT.100691844  DT.100740759  DT.100691853 
    DT.100778417  DT.100833962  DT.75188310 

    24/146 AceView cDNA sequences (see all 146):

    CD724253 BQ011099 AK097254 AA300221 AW271404 AY157986 AI262165 AI934393 
    AI913556 AY157987 BG501962 AI161087 AI199816 BM801562 CA867170 CB957168 
    AI693746 AW195464 BU678881 BI465043 BQ268721 BE048575 AI207692 AF151879 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for TPRKB (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d ^ 9
    SP1:                                -                                         -     -     -                       -     -                                 
    SP2:                                -                                         -     -     -                                                               
    SP3:                                -                       -     -           -     -     -                       -     -                                 
    SP4:                                -                       -     -           -     -     -                       -     -     -     -     -     -         
    SP5:                                -                       -     -           -     -     -                       -     -                                 


    ECgene alternative splicing isoforms for TPRKB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TPRKB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGGCACCA
    TPRKB Expression
    About this image


    See TPRKB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TPRKB

    SOURCE GeneReport for Unigene cluster: Hs.157401

    UniProtKB/Swiss-Prot: TPRKB_HUMAN, Q9Y3C4
    Tissue specificity: Widely expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TPRKB gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tprkb1 , 5 Tp53rk binding protein1, 5 86.1(n)1
    85.14(a)1
      6 (37.53 cM)5
    697861  NM_001170488.11  NP_001163959.11 
     859157385 
    chicken
    (Gallus gallus)
    Aves TPRKB1 TP53RK binding protein 73.56(n)
    69.54(a)
      425906  XM_423597.3  XP_423597.2 
    lizard
    (Anolis carolinensis)
    Reptilia TPRKB6
    Uncharacterized protein
    67(a)
    1 ↔ 1
    5(99342254-99350976)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC532772 hypothetical protein MGC53277 75.4(n)    BC045235.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tprkb1 Tp53rk binding protein 64.94(n)
    56.9(a)
      492501  NM_001007373.1  NP_001007374.1 
    worm
    (Caenorhabditis elegans)
    Secernentea W03F8.41 Protein W03F8.4 49.02(n)
    37.06(a)
      177293  NM_068334.2  NP_500735.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CGI121(YML036W)4 Component of the EKC/KEOPS complex with Bud32p, Kae1p, more   --   13(205642-206293) 854972  NP_013676.2 


    ENSEMBL Gene Tree for TPRKB (if available)
    TreeFam Gene Tree for TPRKB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TPRKB gene

    TPRKB for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TPRKB
    PGOHUM00000238706 PGOHUM00000248771


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/222 SNPs in TPRKB are shown (see all 222)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446369651,2
    --73956584(+) GTAACC/TGATTA 1 -- ds50010--------
    rs1149398221,2
    C,F--73956588(+) CTGATG/TATCTT 1 -- ds50010--------
    rs2021588391,2
    C--73956647(+) TTTTTG/TGTTTT 1 -- ds50010--------
    rs61468091,2
    C--73956659(+) TTTTT-/TTGGTT
    TTTTTTTTT
    GAGAC
    2 -- ds5001 cds11Minor allele frequency- TTGGTTTTTTTTTTT:0.00NA 2
    rs130205171,2
    C--73956744(+) TCATGT/CGATTC 1 -- ds50015Minor allele frequency- C:0.10NA CSA 10
    rs1492839441,2
    --73956798(+) CATCAC/TGCCCA 1 -- ds50010--------
    rs127137941,2
    C,F--73956846(+) ATGTTG/AGCCAG 1 -- ds50016Minor allele frequency- A:0.18NA WA CSA 11
    rs129975681,2
    C--73956881(+) GGTGAC/TCCACC 1 -- ds50015Minor allele frequency- T:0.10NA CSA 10
    rs1902782291,2
    --73956931(+) CCACCA/GTGCCT 1 -- ds50010--------
    rs678051621,2
    C--73956941(+) TGGCC-/TTTTTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TPRKB (73956231 - 73964527 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TPRKB:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv874276CNV Loss21882294
    nsv834260CNV Gain17160897
    essv105CNV CNV17122850
    dgv1197e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TPRKB
    DNA2.0 Custom Variant and Variant Library Synthesis for TPRKB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608680    OMIM disorders: --

    2 diseases for TPRKB:    About MalaCards
    kidney disease    


    TPRKB for disorders           About GeneDecksing


    Export disorders for TPRKB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TPRKB gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with TPRKB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of CGI-121, a novel PRPK (p53-related protein kinase)- binding protein. (PubMed id 12659830)1, 2, 3 Miyoshi A.... Ueda N. (2003)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    3. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    4. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    5. The human EKC/KEOPS complex is recruited to Cullin2 ub iquitin ligases by the human tumour antigen PRAME. (PubMed id 22912744)1 Costessi A....Stunnenberg H.G. (2012)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    8. A genome-wide metabolic QTL analysis in Europeans impl icates two loci shaped by recent positive selection. (PubMed id 21931564)1 Nicholson G....Holmes C.C. (2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51002 HGNC: 24259 AceView: CGI-121 Ensembl:ENSG00000144034 euGenes: HUgn51002
    ECgene: TPRKB H-InvDB: TPRKB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TPRKB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TPRKB gene:
    Search GeneIP for patents involving TPRKB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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