TPRG1L Gene
protein-coding GIFtS: 45
GCID: GC01P003532
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tumor protein p63 regulated 1-like(Previous names: family with sequence similarity 79, member A )
(Previous symbol: FAM79A)
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Aliases
for TPRG1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tumor Protein P63 Regulated 1-Like1 2 | | H-Mover1 | | FAM79A1 2 3 | | Mover1 | | RP11-46F15.31 2 | | Tumor Protein P63-Regulated Gene 1-Like Protein2 | | Family With Sequence Similarity 79, Member A1 2 | | MOVER3 | | Mossy Fiber Terminal-Associated Vertebrate-Specific Presynaptic Protein2 3 | | Protein FAM79A3 | | FLJ218111 | | |
Export aliases for TPRG1L gene to outside databasesPrevious GC identifer: GC01P002837 |
Summaries
for TPRG1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TPRG1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004350.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TPRG1L gene promoter:
HOXA9 HOXA9B p53 NRSF form 1 NRSF form 2 Meis-1b AREB6 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TPRG1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPRG1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.32 Ensembl cytogenetic band: 1p36.32 HGNC cytogenetic band: 1p36.32TPRG1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P003532: view genomic region
(about GC identifiers)
Start:
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3,541,556 bp from pter |
End:
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3,546,695 bp from pter |
Size:
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5,140 bases |
Orientation:
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plus strand |
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Proteins
for TPRG1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TPRGL_HUMAN, Q5T0D9 (See
protein sequence)Recommended Name: Tumor protein p63-regulated gene 1-like protein Size: 272 amino acids; 30212 Da
Subunit: Interacts with BSN (By similarity)
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle (By similarity). Note=Localized topresynaptic nerve terminals (By similarity)
Secondary accessions: A8K1K4 Q8WV04Alternative splicing: 2 isoforms: Q5T0D9-1 Q5T0D9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TPRG1L: NX_Q5T0D9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T0D9
TPRG1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_877429.2
ENSEMBL proteins: ENSP00000367595 ENSP00000339714 ENSP00000415217
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TPRG1L for ontologies About GeneDecksing
TPRG1L Antibody Products:
Assay Products for TPRG1L: |
Protein
Domains /
Families
for TPRG1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TPRG1L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5T0D9ProtoNet protein and cluster: Q5T0D9 UniProtKB/Swiss-Prot: TPRGL_HUMAN, Q5T0D9Similarity: Belongs to the TPRG1 family |
Function
for TPRG1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPRG1L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPRG1L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPRG1L |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042802 | identical protein binding |
IEA | -- |
TPRG1L for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TPRG1L:
|
Pathways & Interactions
for TPRG1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TPRG1L
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/7 Interacting proteins for TPRG1L (Q5T0D93 ENSP000003675954) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
|
Drugs & Compounds
for TPRG1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TPRG1L
Search CenterWatch for drugs/clinical trials and news about TPRG1L / TPRGL
|
Transcripts
for TPRG1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TPRG1L gene: NM_182752.3 Unigene Cluster for TPRG1L: Tumor protein p63 regulated 1-like Hs.20529 [show with all ESTs]Unigene Representative Sequence: NM_1827523 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378344(uc001akm.3 uc009vlj.3) ENST00000344579 ENST00000456805
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPRG1L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPRG1L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TPRG1L (NM_182752) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TPRG1L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPRG1L |
Additional cDNA sequence: AK025409.1 AK025464.1 AK096427.1 AK289919.1 AK298343.1 BC019034.2 BC114609.1 7 DOTS entries: DT.40316374 DT.452291 DT.87015841 DT.100783784 DT.100783785 DT.97846026 DT.95188009 24/202 AceView cDNA sequences (see all 202): AA854468 BG764620 BG945913 AI637912 BE857132 CR617441 AI674992 AA588719 CD244711 AI357751 BX464752 AI783941 AI084147 AI684853 AI720426 AA974056 F24133 H20382 NM_182752 AI686224 CA396871 BM476269 BM795290 BM745410
GeneLoc Exon Structure
|
Expression
for TPRG1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TPRG1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTTGAGTGT
About this image
See TPRG1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TPRG1L
SOURCE GeneReport for Unigene cluster: Hs.20529
SABiosciences Custom PCR Arrays for TPRG1L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TPRG1L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TPRG1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPRG1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPRG1L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPRG1L |
Orthologs
for TPRG1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TPRG1L gene from 3/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TPRG1L1 |
tumor protein p63 regulated 1-like |
70.4(n)
73.75(a) |
|
419384 XM_417547.3 XP_417547.2 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.237482 |
Xenopus laevis transcribed sequences |
74.23(n) |
|
CA981787.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.152002 |
Transcribed sequences |
73.68(n) |
|
CK395596.1 |
ENSEMBL Gene Tree for TPRG1L (if available)
TreeFam Gene Tree for TPRG1L (if available) |
Paralogs
for TPRG1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TPRG1L gene
- TPRG12
1 SIMAP similar gene for TPRG1L using alignment to 2 protein entries: TPRGL_HUMAN (see all proteins):TPRG1
TPRG1L for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TPRG1L
PGOHUM00000234814
|
Genomic Variants
for TPRG1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TPRG1L (3541556 - 3546695 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TPRG1L
2 CNVs: 29825 3278 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPRG1L |
|
Disorders
/ Diseases
for TPRG1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TPRG1L for disorders About MalaCards
TPRG1L for disorders About GeneDecksing
OMIM gene information: 611460
OMIM disorders: --
Export disorders for TPRG1L gene to outside databases
|
Publications
for TPRG1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TPRG1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with TPRG1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Mover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses. (PubMed id 17869247)1 Kremer T....Dresbach T. (2007)
|
External Searches for TPRG1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TPRG1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TPRG1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TPRG1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TPRG1L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TPRG1L gene:
Search GeneIP for patents involving TPRG1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TPRG1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | TPRG1L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPRG1L |
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