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Aliases for TPRG1L Gene

Aliases for TPRG1L Gene

  • Tumor Protein P63 Regulated 1 Like 2 3 5
  • Mossy Fiber Terminal-Associated Vertebrate-Specific Presynaptic Protein 3 4
  • Family With Sequence Similarity 79, Member A 2 3
  • FAM79A 3 4
  • Mover 3 4
  • Tumor Protein P63-Regulated Gene 1-Like Protein 3
  • Protein FAM79A 4
  • RP11-46F15.3 3
  • H-Mover 3

External Ids for TPRG1L Gene

Previous HGNC Symbols for TPRG1L Gene

  • FAM79A

Previous GeneCards Identifiers for TPRG1L Gene

  • GC01P003532
  • GC01P002837

Summaries for TPRG1L Gene

GeneCards Summary for TPRG1L Gene

TPRG1L (Tumor Protein P63 Regulated 1 Like) is a Protein Coding gene. GO annotations related to this gene include identical protein binding. An important paralog of this gene is TPRG1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPRG1L Gene

Genomics for TPRG1L Gene

Regulatory Elements for TPRG1L Gene

Enhancers for TPRG1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G003541 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -79.3 -79345 8.2 PKNOX1 MLX ZFP64 ARID4B DMAP1 GLIS2 FOS SP5 MXD4 ZHX2 TP73-AS1 MEGF6 ENSG00000238260 TPRG1L ENSG00000225931 ARHGEF16 LOC105378608 GC01M003505
GH01G003539 1.5 Ensembl ENCODE dbSUPER 11.6 -85.0 -84970 2.4 MLX ARID4B DMAP1 ZNF48 SLC30A9 SP3 MCM3 SP5 MXD4 MIER2 MEGF6 MIR551A TPRG1L ENSG00000238260 LOC105378610 LOC105378608 GC01M003505
GH01G003618 1.1 Ensembl ENCODE 15.5 -5.8 -5785 1.2 HDAC1 PKNOX1 ATF1 ZNF2 RAD21 TCF12 ZNF143 CREM MIXL1 ZNF654 TPRG1L WRAP73 LRRC47 TTC34 ENSG00000238260 LOC105378607
GH01G003538 1.4 Ensembl ENCODE dbSUPER 11.6 -86.5 -86492 0.6 TBP ZSCAN4 ARID4B THRB ZNF48 RARA GLIS2 PCBP1 CREM EGR2 MIR551A TPRG1L ENSG00000238260 MEGF6 LOC105378610 TP73-AS1 LOC105378608 GC01M003505
GH01G003483 1.3 Ensembl ENCODE dbSUPER 11.6 -141.1 -141059 0.3 CTCF RB1 TEAD4 INSM2 ZNF2 RAD21 ZBTB48 POLR2A HSF1 SMC3 MEGF6 ENSG00000238260 TPRG1L TP73 WRAP73 ENSG00000272088 GC01M003454
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TPRG1L on UCSC Golden Path with GeneCards custom track

Promoters for TPRG1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000000486 -92 1801 HDGF PKNOX1 FOXA2 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207

Genomic Location for TPRG1L Gene

3,624,992 bp from pter
3,630,131 bp from pter
5,140 bases
Plus strand

Genomic View for TPRG1L Gene

Genes around TPRG1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPRG1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPRG1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPRG1L Gene

Proteins for TPRG1L Gene

  • Protein details for TPRG1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor protein p63-regulated gene 1-like protein
    Protein Accession:
    Secondary Accessions:
    • A8K1K4
    • Q8WV04

    Protein attributes for TPRG1L Gene

    272 amino acids
    Molecular mass:
    30212 Da
    Quaternary structure:
    • Interacts with BSN.

    Alternative splice isoforms for TPRG1L Gene


neXtProt entry for TPRG1L Gene

Post-translational modifications for TPRG1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TPRG1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TPRG1L Gene

Domains & Families for TPRG1L Gene

Protein Domains for TPRG1L Gene


Suggested Antigen Peptide Sequences for TPRG1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TPRG1 family.
  • Belongs to the TPRG1 family.
genes like me logo Genes that share domains with TPRG1L: view

No data available for Gene Families for TPRG1L Gene

Function for TPRG1L Gene

Gene Ontology (GO) - Molecular Function for TPRG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with TPRG1L: view
genes like me logo Genes that share phenotypes with TPRG1L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPRG1L Gene

Localization for TPRG1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPRG1L Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=Localized to presynaptic nerve terminals. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPRG1L gene
Compartment Confidence
extracellular 5
cytoskeleton 2
nucleus 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TPRG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008021 synaptic vesicle ISS 17869247
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with TPRG1L: view

Pathways & Interactions for TPRG1L Gene

SuperPathways for TPRG1L Gene

No Data Available

Interacting Proteins for TPRG1L Gene

Selected Interacting proteins: Q5T0D9-TPRGL_HUMAN for TPRG1L Gene via IID

Gene Ontology (GO) - Biological Process for TPRG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TPRG1L: view

No data available for Pathways by source and SIGNOR curated interactions for TPRG1L Gene

Drugs & Compounds for TPRG1L Gene

No Compound Related Data Available

Transcripts for TPRG1L Gene

mRNA/cDNA for TPRG1L Gene

Unigene Clusters for TPRG1L Gene

Tumor protein p63 regulated 1-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPRG1L Gene

No ASD Table

Relevant External Links for TPRG1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPRG1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPRG1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TPRG1L Gene

This gene is overexpressed in Frontal cortex (24.3) and Brain (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TPRG1L Gene

Protein tissue co-expression partners for TPRG1L Gene

NURSA nuclear receptor signaling pathways regulating expression of TPRG1L Gene:


SOURCE GeneReport for Unigene cluster for TPRG1L Gene:


Evidence on tissue expression from TISSUES for TPRG1L Gene

  • Nervous system(4.8)
  • Muscle(2.5)
  • Heart(2.2)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with TPRG1L: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPRG1L Gene

Orthologs for TPRG1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for TPRG1L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TPRG1L 35
  • 96 (a)
(Canis familiaris)
Mammalia TPRG1L 35
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia TPRG1L 35
  • 88 (a)
(Mus musculus)
Mammalia Tprgl 34 16 35
  • 87.09 (n)
(Rattus norvegicus)
Mammalia Tprg1l 34
  • 86.59 (n)
(Bos Taurus)
Mammalia TPRG1L 34 35
  • 85.29 (n)
(Monodelphis domestica)
Mammalia TPRG1L 35
  • 81 (a)
(Gallus gallus)
Aves TPRG1L 34 35
  • 77.35 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tprg1l 34
  • 71.49 (n)
Str.11829 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.23748 34
(Danio rerio)
Actinopterygii tprg1l 34 35
  • 67.77 (n)
Dr.15200 34
Species where no ortholog for TPRG1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TPRG1L Gene

Gene Tree for TPRG1L (if available)
Gene Tree for TPRG1L (if available)

Paralogs for TPRG1L Gene

Paralogs for TPRG1L Gene

(1) SIMAP similar genes for TPRG1L Gene using alignment to 1 proteins: Pseudogenes for TPRG1L Gene

genes like me logo Genes that share paralogs with TPRG1L: view

Variants for TPRG1L Gene

Sequence variations from dbSNP and Humsavar for TPRG1L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000532298 -- 3,623,899(+) CCCAG(C/G)TGCCG intron-variant, upstream-variant-2KB
rs1000762719 -- 3,629,185(+) CTTTT(A/G)GAAAT utr-variant-3-prime
rs1001342346 -- 3,627,926(+) ATCTG(A/G)GTGGG intron-variant
rs1001880513 -- 3,628,096(+) TCGGC(A/C)TGGTT intron-variant
rs1002069619 -- 3,623,675(+) TCTTT(C/T)CTCTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TPRG1L Gene

Variant ID Type Subtype PubMed ID
esv2758915 CNV gain 17122850
esv3585042 CNV gain 21293372
esv3585044 CNV gain 21293372
esv3585045 CNV gain 21293372
nsv1001715 CNV loss 25217958
nsv1012423 CNV gain 25217958
nsv470687 CNV loss 18288195
nsv951959 CNV deletion 24416366

Variation tolerance for TPRG1L Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPRG1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPRG1L Gene

Disorders for TPRG1L Gene

Relevant External Links for TPRG1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TPRG1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPRG1L Gene

Publications for TPRG1L Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M. … Yates J.R. (J. Proteome Res. 2009) 3 64

Products for TPRG1L Gene

Sources for TPRG1L Gene

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