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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TPRG1 Gene

protein-coding   GIFtS: 45
GCID: GC03P188665

Tumor Protein P63 Regulated 1

(Previous names: family with sequence similarity 79, member B)
(Previous symbol: FAM79B)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Protein P63 Regulated 11 2
FAM79B1 2 3
Family With Sequence Similarity 79, Member B1 2
Tumor Protein P63-Regulated Gene 1 Protein2
Protein FAM79B3

External Ids:    HGNC: 247591   Entrez Gene: 2853862   Ensembl: ENSG000001880017   UniProtKB: Q6ZUI03   

Export aliases for TPRG1 gene to outside databases

Previous GC identifers: GC03P190375 GC03P186294


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TPRG1 Gene: 
TPRG1 (tumor protein p63 regulated 1) is a protein-coding gene. Diseases associated with TPRG1 include lipoma, and parkinson's disease. An important paralog of this gene is TPRG1L.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TPRG1 gene promoter:
         TBP   Pbx1a   MyoD   POU3F2   FOXI1   PPAR-alpha   HFH-1   FOXO1a   RSRFC4   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTPRG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TPRG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPRG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28   Ensembl cytogenetic band:  3q28   HGNC cytogenetic band: 3q28

TPRG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPRG1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P188665:  view genomic region     (about GC identifiers)

Start:
188,665,003 bp from pter      End:
189,043,093 bp from pter
Size:
378,091 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TPRG1_HUMAN, Q6ZUI0 (See protein sequence)
Recommended Name: Tumor protein p63-regulated gene 1 protein  
Size: 275 amino acids; 31230 Da

Explore the universe of human proteins at neXtProt for TPRG1: NX_Q6ZUI0

Explore proteomics data for TPRG1 at MOPED 

TPRG1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TPRG1 Protein Expression

REFSEQ proteins: NP_940887.1  
ENSEMBL proteins: 
 ENSP00000412547   ENSP00000415413   ENSP00000341031   ENSP00000399133   ENSP00000400171  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IEA--

TPRG1 for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for TPRG1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR022158 Inositol_phosphatase

Graphical View of Domain Structure for InterPro Entry Q6ZUI0

ProtoNet protein and cluster: Q6ZUI0

UniProtKB/Swiss-Prot: TPRG1_HUMAN, Q6ZUI0
Similarity: Belongs to the TPRG1 family


TPRG1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     1 GenomeRNAi human phenotype for TPRG1:
 High actin ratio cells 

Animal Models:
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SwitchGear 3'UTR luciferase reporter plasmidTPRG1 3' UTR sequence
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TPRG1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TPRG1

Search CenterWatch for drugs/clinical trials and news about TPRG1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TPRG1 gene: 
NM_198485.3  

Unigene Cluster for TPRG1:

Tumor protein p63 regulated 1
Hs.729544  [show with all ESTs]
Unigene Representative Sequence: NM_198485
15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000433971 ENST00000496671 ENST00000412373 ENST00000479720 ENST00000497628
ENST00000488841 ENST00000473790 ENST00000464152 ENST00000460613 ENST00000345063(uc003frv.2 uc003frw.2)
ENST00000456832 ENST00000493725 ENST00000425670 ENST00000485836 ENST00000481307


miRNA
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Inhib. RNA
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                     Customized lentivirus expression plasmids for stable overexpression of TPRG1 
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPRG1

Additional mRNA sequence: 

AK123232.1 AK125682.1 BC101550.1 BC101552.1 

7 DOTS entries:

DT.101977742  DT.100738815  DT.91697740  DT.91697735  DT.91697738  DT.91759662  DT.120875958 

24/61 AceView cDNA sequences (see all 61):

AI914857 BG208693 BG217803 CD369346 AK123232 AI675695 AI911496 AF315716 
BG214963 CK429484 AW015415 CB127698 CB528961 AA631029 AW089920 BG188653 
BG216077 AK125682 AI305177 BG204093 BG182863 CD367314 BX093223 AA505628 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TPRG1 expression in normal human tissues (normalized intensities)      TPRG1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGAGACCCTG
TPRG1 Expression
About this image


TPRG1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/4 selected tissues (see all 4) fully expand
 
 Thymus (Hematopoietic System)
         T Helper Cells Thymus
 
 Endothelium (Cardiovascular System)
         blood vessel   
 
 Blood (Cardiovascular System)
         T Helper Cells Thymus
 
 Spinal Cord (Nervous System)
         motor neurons   

 -- (Integumentary System)
         skin   

See TPRG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TPRG1

SOURCE GeneReport for Unigene cluster: Hs.729544
    SABiosciences Custom PCR Arrays for TPRG1
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPRG1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPRG1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TPRG1 gene from 4/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tprg1 , 5 transformation related protein 63 regulated1, 5 84.73(n)1
82.55(a)1
  16 (17.00 cM)5
713381  NM_175165.31  NP_780374.11 
 252868175 
lizard
(Anolis carolinensis)
Reptilia TPRG16
Uncharacterized protein
58(a)
1 ↔ 1
GL343360.1(931370-998841)
African clawed frog
(Xenopus laevis)
Amphibia MGC685142 hypothetical protein MGC68514 78.63(n)    BC063732.1 
zebrafish
(Danio rerio)
Actinopterygii tprg11 tumor protein p63 regulated 1 55.39(n)
45.11(a)
  560596  NM_001089528.1  NP_001082997.1 


ENSEMBL Gene Tree for TPRG1 (if available)
TreeFam Gene Tree for TPRG1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TPRG1 gene
TPRG1L2  
1 SIMAP similar gene for TPRG1 using alignment to 4 protein entries:     TPRG1_HUMAN (see all proteins):
TPRG1L

TPRG1 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for TPRG1
PGOHUM00000246810


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/3106 SNPs in TPRG1 are shown (see all 3106)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs98411541,2
C,F,H--188887922(+) CCAGCA/CTGTCT 1 -- us2k14Minor allele frequency- C:0.00EA NS WA 410
rs1153611051,2
C,F--188887949(+) TTGTGC/ACCCCA 1 -- us2k11Minor allele frequency- A:0.03NA 120
rs1868245591,2
--188888042(+) TGGCGA/TCTAAG 1 -- us2k10--------
rs124974051,2
C,F,H--188888245(+) CCACCG/ACTGTG 1 -- us2k18Minor allele frequency- A:0.10EA NS NA WA 544
rs38569251,2
C,F,A,H--188888375(-) TAAGGT/AGCTCA 1 -- us2k119Minor allele frequency- A:0.39EA NS NA WA CSA 819
rs1461637691,2
C--188888479(+) TAGTAC/TACATG 1 -- us2k10--------
rs15627591,2
C,F,O,A,H--188888585(-) TGAAGG/CGATTC 1 -- us2k124Minor allele frequency- C:0.47MN EA NS NA WA CSA 1491
rs15627581,2
C,F,O,A,H--188888700(-) GGAACA/GGGTGT 1 -- us2k127Minor allele frequency- G:0.47EA NS NA WA CSA 2263
rs1401196901,2
--188888703(+) CCCGTC/TCCTCC 1 -- us2k10--------
rs1139129321,2
C--188888771(+) TTAGGC/ATAGAA 1 -- us2k11Minor allele frequency- A:0.00CSA 1

HapMap Linkage Disequilibrium report for TPRG1 (188665003 - 188915003 bp, first 250kb of TPRG1)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for TPRG1:    About this table     
Variant IDTypeSubtypePubMed ID
esv2726358CNV Deletion23290073
nsv236710CNV Loss16902084
nsv829819CNV Gain17160897

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for TPRG1:    About MalaCards
lipoma    parkinson's disease

1 disease from the University of Copenhagen DISEASES database for TPRG1:
Lipoma

TPRG1 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
Genetic Association Database (GAD): TPRG1
Human Genome Epidemiology (HuGE) Navigator: TPRG1 (1 document)

Export disorders for TPRG1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TPRG1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TPRG1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: l arge-scale collaborative study. (PubMed id 19475631)1, 4 Evangelou E....Ioannidis J.P. (2010)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  4. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)4 Hwang S.J....Fox C.S. (2007)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 285386 HGNC: 24759 AceView: FLJ41238 Ensembl:ENSG00000188001 euGenes: HUgn285386
ECgene: TPRG1 H-InvDB: TPRG1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TPRG1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TPRG1 gene:
Search GeneIP for patents involving TPRG1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Proteins for TPRG1
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 inGenious Targeting Laboratory - Custom generated mouse model solutions for TPRG1
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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