TPRG1 Gene
protein-coding GIFtS: 44
GCID: GC03P188665
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tumor protein p63 regulated 1(Previous names: family with sequence similarity 79, member B )
(Previous symbol: FAM79B)
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Aliases
for TPRG1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tumor Protein P63 Regulated 11 2 | | FLJ436941 | | FAM79B1 2 3 | | Tumor Protein P63-Regulated Gene 1 Protein2 | | Family With Sequence Similarity 79, Member B1 2 | | Protein FAM79B3 | | FLJ412381 | | |
Export aliases for TPRG1 gene to outside databasesPrevious GC identifers: GC03P190375 GC03P186294 |
Summaries
for TPRG1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TPRG1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TPRG1 gene promoter:
TBP Pbx1a MyoD POU3F2 FOXI1 PPAR-alpha HFH-1 FOXO1a RSRFC4 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TPRG1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPRG1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q28 Ensembl cytogenetic band: 3q28 HGNC cytogenetic band: 3q28TPRG1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P188665: view genomic region
(about GC identifiers)
Start:
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188,665,003 bp from pter |
End:
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189,043,093 bp from pter |
Size:
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378,091 bases |
Orientation:
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plus strand |
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Proteins
for TPRG1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TPRG1_HUMAN, Q6ZUI0 (See
protein sequence)Recommended Name: Tumor protein p63-regulated gene 1 protein Size: 275 amino acids; 31230 DaExplore the universe of human proteins at neXtProt for TPRG1: NX_Q6ZUI0
TPRG1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_940887.1
ENSEMBL proteins: ENSP00000412547 ENSP00000415413 ENSP00000341031 ENSP00000399133 ENSP00000400171
Human Recombinant Protein Products for TPRG1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005737 | cytoplasm |
IEA | -- |
TPRG1 for ontologies About GeneDecksing
TPRG1 Antibody Products:
Assay Products for TPRG1: |
Protein
Domains /
Families
for TPRG1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TPRG1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6ZUI0ProtoNet protein and cluster: Q6ZUI0 UniProtKB/Swiss-Prot: TPRG1_HUMAN, Q6ZUI0Similarity: Belongs to the TPRG1 family |
Function
for TPRG1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for TPRG1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPRG1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPRG1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TPRG1 (NM_182752) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TPRG1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPRG1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPRG1 |
|
Pathways & Interactions
for TPRG1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TPRG1
|
Drugs & Compounds
for TPRG1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TPRG1
Search CenterWatch for drugs/clinical trials and news about TPRG1
|
Transcripts
for TPRG1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TPRG1 gene: NM_198485.3 Unigene Cluster for TPRG1: Tumor protein p63 regulated 1 Hs.729544 [show with all ESTs]Unigene Representative Sequence: NM_19848515 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000433971 ENST00000496671 ENST00000412373 ENST00000479720 ENST00000497628
ENST00000488841 ENST00000473790 ENST00000464152 ENST00000460613 ENST00000345063(uc003frv.2 uc003frw.2)
ENST00000456832 ENST00000493725 ENST00000425670 ENST00000485836 ENST00000481307
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPRG1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPRG1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TPRG1 (NM_182752) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TPRG1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPRG1 |
Additional cDNA sequence: AK123232.1 AK125682.1 BC101550.1 BC101552.1 8 DOTS entries: DT.101977742 DT.100738815 DT.91697740 DT.91697735 DT.91697738 DT.91759662 DT.120875958 DT.40295803 24/61 AceView cDNA sequences (see all 61): AK123232 AF315716 AI914857 BG217803 AI911496 BG208693 AI675695 CD369346 AK125682 AW629527 BG204093 AI221838 BG216077 AA631029 BG214963 CK429484 AW089920 BG182863 AI859619 BG205568 CD368922 AA961186 BX093223 CB528961
GeneLoc Exon Structure
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Expression
for TPRG1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TPRG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAGACCCTG
About this image
See TPRG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TPRG1
SOURCE GeneReport for Unigene cluster: Hs.729544
SABiosciences Custom PCR Arrays for TPRG1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TPRG1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TPRG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPRG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPRG1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPRG1 |
Orthologs
for TPRG1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TPRG1 gene from 4/15 species (see all 15) About this table
ENSEMBL Gene Tree for TPRG1 (if available)
TreeFam Gene Tree for TPRG1 (if available) |
Paralogs
for TPRG1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TPRG1 gene
- TPRG1L2
1 SIMAP similar gene for TPRG1 using alignment to 4 protein entries: TPRG1_HUMAN (see all proteins):TPRG1L
TPRG1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TPRG1
PGOHUM00000246810
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Genomic Variants
for TPRG1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TPRG1 (188665003 - 188915003 bp, first 250kb of TPRG1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TPRG1
1 CNV: 6224 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPRG1 |
|
Disorders
/ Diseases
for TPRG1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TPRG1 for disorders About GeneDecksing
2  diseases for TPRG1: About MalaCardslipoma parkinson's disease
1 disease from the University of Copenhagen DISEASES database for TPRG1:Lipoma Human Genome Epidemiology (HuGE) Navigator: TPRG1 (1 document)
Export disorders for TPRG1 gene to outside databases
|
Publications
for TPRG1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TPRG1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TPRG1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: l arge-scale collaborative study. (PubMed id 19475631)1 Evangelou E....Ioannidis J.P. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TPRG1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TPRG1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TPRG1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TPRG1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TPRG1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TPRG1 gene:
Search GeneIP for patents involving TPRG1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TPRG1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TPRG1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TPRG1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TPRG1 | | | OriGene Protein Over-expression Lysate for TPRG1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TPRG1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPRG1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPRG1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TPRG1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TPRG1 | | OriGene Custom Protein Services for TPRG1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TPRG1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPRG1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPRG1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TPRG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPRG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPRG1 |
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 |  |  |  | |
| | | | Search Tocris compounds for TPRG1 |
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 | | | TPRG1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPRG1 |
|  |  |  |  | | | | ThermoFisher Antibody for TPRG1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPRG1 |
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