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Aliases for TPRG1 Gene

Aliases for TPRG1 Gene

  • Tumor Protein P63 Regulated 1 2 3 5
  • Family With Sequence Similarity 79, Member B 2 3
  • FAM79B 3 4
  • Tumor Protein P63-Regulated Gene 1 Protein 3
  • Protein FAM79B 4

External Ids for TPRG1 Gene

Previous HGNC Symbols for TPRG1 Gene

  • FAM79B

Previous GeneCards Identifiers for TPRG1 Gene

  • GC03P190375
  • GC03P188665
  • GC03P186294

Summaries for TPRG1 Gene

GeneCards Summary for TPRG1 Gene

TPRG1 (Tumor Protein P63 Regulated 1) is a Protein Coding gene. An important paralog of this gene is TPRG1L.

Additional gene information for TPRG1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPRG1 Gene

Genomics for TPRG1 Gene

GeneHancer (GH) Regulatory Elements for TPRG1 Gene

Promoters and enhancers for TPRG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I188946 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 550.8 +1.8 1848 6.1 FOXA2 SIN3A ZNF2 YY1 ZNF121 GLIS2 FOS KLF13 SP3 RXRA TPRG1-AS1 TPRG1 GC03P188961
GH03I189193 Promoter 0.7 EPDnew 550.1 +246.8 246792 0.1 ATF7 ATF2 TPRG1 TPRG1-AS2 LOC647299
GH03I188945 Enhancer 0.6 FANTOM5 dbSUPER 550.8 -1.5 -1506 0.4 ZMYM3 TPRG1 TPRG1-AS1 GC03P188886
GH03I189171 Promoter 0.5 EPDnew 550.1 +224.7 224740 0.1 TPRG1 TPRG1-AS2 LOC647299
GH03I188914 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -32.5 -32513 1.4 FOXA2 RXRA MAX BATF RAD21 NR2F2 JUND ATF3 HNF4G HNF4A TPRG1 TPRG1-AS1 GC03P188886
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TPRG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TPRG1 gene promoter:

Genomic Locations for TPRG1 Gene

Genomic Locations for TPRG1 Gene
chr3:188,947,214-189,325,304
(GRCh38/hg38)
Size:
378,091 bases
Orientation:
Plus strand
chr3:188,665,003-189,043,093
(GRCh37/hg19)

Genomic View for TPRG1 Gene

Genes around TPRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPRG1 Gene

Proteins for TPRG1 Gene

  • Protein details for TPRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZUI0-TPRG1_HUMAN
    Recommended name:
    Tumor protein p63-regulated gene 1 protein
    Protein Accession:
    Q6ZUI0

    Protein attributes for TPRG1 Gene

    Size:
    275 amino acids
    Molecular mass:
    31230 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TPRG1 Gene

Post-translational modifications for TPRG1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TPRG1 Gene

Domains & Families for TPRG1 Gene

Gene Families for TPRG1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TPRG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TPRG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZUI0

UniProtKB/Swiss-Prot:

TPRG1_HUMAN :
  • Belongs to the TPRG1 family.
Family:
  • Belongs to the TPRG1 family.
genes like me logo Genes that share domains with TPRG1: view

Function for TPRG1 Gene

Phenotypes From GWAS Catalog for TPRG1 Gene

Phenotypes for TPRG1 Gene

GenomeRNAi human phenotypes for TPRG1:
genes like me logo Genes that share phenotypes with TPRG1: view

Animal Model Products

CRISPR Products

miRNA for TPRG1 Gene

miRTarBase miRNAs that target TPRG1

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPRG1 Gene

Localization for TPRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPRG1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPRG1 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TPRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TPRG1: view

Pathways & Interactions for TPRG1 Gene

SuperPathways for TPRG1 Gene

No Data Available

Interacting Proteins for TPRG1 Gene

Gene Ontology (GO) - Biological Process for TPRG1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TPRG1 Gene

Drugs & Compounds for TPRG1 Gene

No Compound Related Data Available

Transcripts for TPRG1 Gene

Unigene Clusters for TPRG1 Gene

Tumor protein p63 regulated 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPRG1 Gene

No ASD Table

Relevant External Links for TPRG1 Gene

GeneLoc Exon Structure for
TPRG1
ECgene alternative splicing isoforms for
TPRG1

Expression for TPRG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPRG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TPRG1 Gene

This gene is overexpressed in Esophagus - Mucosa (x9.8), Vagina (x6.7), Skin - Sun Exposed (Lower leg) (x5.9), Skin - Not Sun Exposed (Suprapubic) (x5.4), and Cervix - Ectocervix (x4.7).

Protein differential expression in normal tissues from HIPED for TPRG1 Gene

This gene is overexpressed in Cervix (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TPRG1 Gene



Protein tissue co-expression partners for TPRG1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TPRG1 Gene:

TPRG1

SOURCE GeneReport for Unigene cluster for TPRG1 Gene:

Hs.729544

mRNA Expression by UniProt/SwissProt for TPRG1 Gene:

Q6ZUI0-TPRG1_HUMAN
Tissue specificity: Expressed in the epidermal layer of the skin.

Evidence on tissue expression from TISSUES for TPRG1 Gene

  • Nervous system(4)
  • Kidney(2.7)
genes like me logo Genes that share expression patterns with TPRG1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TPRG1 Gene

Orthologs for TPRG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TPRG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPRG1 33 34
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia TPRG1 33 34
  • 90.18 (n)
cow
(Bos Taurus)
Mammalia TPRG1 33 34
  • 87.52 (n)
rat
(Rattus norvegicus)
Mammalia Tprg1 33
  • 84.91 (n)
mouse
(Mus musculus)
Mammalia Tprg 33 16 34
  • 84.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TPRG1 34
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TPRG1 34
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TPRG1 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tprg1 33
  • 60.49 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68514 33
zebrafish
(Danio rerio)
Actinopterygii tprg1 33 34
  • 57.05 (n)
Species where no ortholog for TPRG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TPRG1 Gene

ENSEMBL:
Gene Tree for TPRG1 (if available)
TreeFam:
Gene Tree for TPRG1 (if available)

Paralogs for TPRG1 Gene

Paralogs for TPRG1 Gene

(1) SIMAP similar genes for TPRG1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TPRG1 Gene

genes like me logo Genes that share paralogs with TPRG1: view

Variants for TPRG1 Gene

Sequence variations from dbSNP and Humsavar for TPRG1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000003247 -- 189,295,775(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000008947 -- 189,276,681(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000009433 -- 189,146,984(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000056188 -- 189,294,570(+) A/T genic_downstream_transcript_variant, intron_variant
rs1000059958 -- 189,276,970(+) A/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TPRG1 Gene

Variant ID Type Subtype PubMed ID
esv2726358 CNV deletion 23290073
nsv236710 CNV deletion 16902084
nsv829819 CNV gain 17160897

Variation tolerance for TPRG1 Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPRG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TPRG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPRG1 Gene

Disorders for TPRG1 Gene

Additional Disease Information for TPRG1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TPRG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPRG1 Gene

Publications for TPRG1 Gene

  1. Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative study. (PMID: 19475631) Evangelou E … Genetic Epidemiology of Parkinson's Disease (GEOPD) Consortium (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PMID: 24144296) Cheng CY … Baird PN (American journal of human genetics 2013) 3 58
  5. Tprg, a gene predominantly expressed in skin, is a direct target of the transcription factor p63. (PMID: 18256694) Antonini D … Missero C (The Journal of investigative dermatology 2008) 4 58

Products for TPRG1 Gene

Sources for TPRG1 Gene

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