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TPRA1 Gene

protein-coding   GIFtS: 46
GCID: GC03M127291

Transmembrane Protein, Adipocyte Asscociated 1

(Previous name: G protein-coupled receptor 175)
(Previous symbol: GPR175)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein, Adipocyte Asscociated 11 2     TPRA402
GPR1751 2 3     Seven Transmembrane Domain Orphan Receptor2
Transmembrane Protein 2271 2 3     Transmembrane Domain Protein Regulated In Adipocytes 40 KDa2
G Protein-Coupled Receptor 1751 2     Transmembrane Protein Adipocyte-Associated 12
Integral Membrane Protein GPR1752 3     Transmembrane Protein, Adipocyte Associated 12
TMEM2272 3     

External Ids:    HGNC: 304131   Entrez Gene: 1316012   Ensembl: ENSG000001638707   OMIM: 6083365   UniProtKB: Q86W333   

Export aliases for TPRA1 gene to outside databases

Previous GC identifers: GC03M128776 GC03M124672


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TPRA1 Gene:
TPRA1 (transmembrane protein, adipocyte asscociated 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TPRA1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTPRA1 promoter sequence
   Search Chromatin IP Primers for TPRA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPRA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.2   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21.2

TPRA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPRA1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M127291:  view genomic region     (about GC identifiers)

Start:
127,291,908 bp from pter      End:
127,317,094 bp from pter
Size:
25,187 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TPRA1_HUMAN, Q86W33 (See protein sequence)
Recommended Name: Transmembrane protein adipocyte-associated 1  
Size: 373 amino acids; 41053 Da
Secondary accessions: A8MVB8 D3DNA9 Q8WZ24 Q96AJ6 Q9P2R4
Alternative splicing: 3 isoforms:  Q86W33-1   Q86W33-2   Q86W33-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TPRA1: NX_Q86W33

Explore proteomics data for TPRA1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys289
  • Glycosylation2 at Asn11, Asn23, Asn361
  • Modification sites at PhosphoSitePlus

  • See TPRA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129525.1  NP_001136118.1  

    ENSEMBL proteins: 
     ENSP00000413428   ENSP00000296210   ENSP00000347748   ENSP00000377056   ENSP00000418827  
     ENSP00000418298   ENSP00000417113   ENSP00000419533   ENSP00000419822   ENSP00000419299  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    O7TM: GPCR / Unclassified : 7TM orphan receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: TPRA1
    Other 7TM proteins

    1 InterPro protein domain:
     IPR018781 Uncharacterised_TM-40

    Graphical View of Domain Structure for InterPro Entry Q86W33

    ProtoNet protein and cluster: Q86W33

    UniProtKB/Swiss-Prot: TPRA1_HUMAN, Q86W33
    Similarity: Belongs to the UPF0359 family


    Find genes that share domains with TPRA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS10342878
         
    Find genes that share ontologies with TPRA1           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Tpra1 (no phenotypes)

    Find genes that share phenotypes with TPRA1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TPRA1
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    miRNA
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    miRTarBase miRNAs that target TPRA1:
    hsa-mir-124-3p (MIRT022414)

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    2 qRT-PCR Assays for microRNAs that regulate TPRA1:
    hsa-miR-3121-3p hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidTPRA1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TPRA1_HUMAN, Q86W33: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TPRA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TPRA1
    Interactions:

        Search GeneGlobe Interaction Network for TPRA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for TPRA1 (ENSP000003477484) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNA11ENSP000000784294STRING: ENSP00000078429
    GNA14ENSP000003658074STRING: ENSP00000365807
    GNAI1ENSP000003430274STRING: ENSP00000343027
    GNAI2ENSP000003129994STRING: ENSP00000312999
    GNAI3ENSP000003588674STRING: ENSP00000358867
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    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process TAS10342878
    GO:0007186G-protein coupled receptor signaling pathway TAS10342878
    GO:0007568aging TAS10342878

    Find genes that share ontologies with TPRA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TPRA1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TPRA1 gene (3 alternative transcripts): 
    NM_016372.2  NM_001136053.2  NM_001142646.2  

    Unigene Cluster for TPRA1:

    Transmembrane protein, adipocyte asscociated 1
    Hs.6418  [show with all ESTs]
    Unigene Representative Sequence: NM_001136053
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000450633(uc003ejl.2) ENST00000296210(uc010hsk.2) ENST00000355552(uc003ejn.2 uc003ejm.3)
    ENST00000393400 ENST00000483868 ENST00000489960 ENST00000465915 ENST00000490290
    ENST00000469111 ENST00000490643 ENST00000462228
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate TPRA1:
    hsa-miR-3121-3p hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidTPRA1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TPRA1
      QuantiFast Probe-based Assays in human, mouse, rat TPRA1

    Additional mRNA sequence: 

    AB037108.1 AF289568.1 BC017058.1 BC050711.2 NR_073377.1 

    15 DOTS entries:

    DT.95344734  DT.97801190  DT.441917  DT.91762792  DT.100769628  DT.95344763  DT.100845188  DT.95344758 
    DT.100834837  DT.120846985  DT.100711872  DT.120846972  DT.95176232  DT.91643520  DT.95344744 

    Selected AceView cDNA sequences (see all 204):

    BQ049700 CK819986 CR621499 BC017058 CR606702 BX381599 CR618881 BQ933854 
    BM919429 BC050711 BX091515 BM273281 BQ021809 CR617714 CR612256 CA447809 
    BI761996 BI759559 BM708201 AI091346 CA449451 BI521243 BQ014454 CA488451 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TPRA1 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b
    SP1:                          -     -                                                     -                       -                     
    SP2:                          -     -                                               -     -                       -                     
    SP3:                                                              -                       -                       -                     
    SP4:        -     -     -     -     -                                                                                                   
    SP5:                          -     -                 -     -                       -     -                                             


    ECgene alternative splicing isoforms for TPRA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TPRA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGATGGAC
    TPRA1 Expression
    About this image

    TPRA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TPRA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6418

    UniProtKB/Swiss-Prot: TPRA1_HUMAN, Q86W33
    Tissue specificity: Ubiquitous, with higher levels in heart, placenta and kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TPRA1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tpra11 , 5 transmembrane protein, adipocyte asscociated 11, 5 86.99(n)1
    92.41(a)1
      6 (39.65 cM)5
    241001  NM_011906.21  NP_036036.21 
     889022515 
    chicken
    (Gallus gallus)
    Aves TPRA11 transmembrane protein, adipocyte asscociated 1 77.78(n)
    87.74(a)
      416028  NM_001030599.1  NP_001025770.1 
    lizard
    (Anolis carolinensis)
    Reptilia TPRA16
    transmembrane protein, adipocyte asscociated 1
    79(a)
    1 ↔ 1
    2(166232347-166271328)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.176552 Transcribed sequence with moderate similarity to protein more 77.21(n)    AL862790.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc75f122 Transcribed sequence with weak similarity to protein more 76.12(n)    57052349 
    worm
    (Caenorhabditis elegans)
    Secernentea tpra-11 tpra-1 44.92(n)
    37.28(a)
      259586  NM_001268428.1  NP_001255357.1 


    ENSEMBL Gene Tree for TPRA1 (if available)
    TreeFam Gene Tree for TPRA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TPRA1 (see all 438)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs787708361,2
    C,F--127291595(+) TTTTAA/CTGGAG 3 -- int11Minor allele frequency- C:0.04WA 118
    rs1841748351,2
    --127291859(+) CTCAGG/TCTCCT 3 -- int10--------
    rs606497951,2
    C,F--127291878(+) CCAGCC/TCCAGT 3 -- int13Minor allele frequency- T:0.05WA EA 240
    rs10435541,2
    C--127291982(-) CATCCA/CCCATG 3 -- ut31 nc-transcript-variant3Minor allele frequency- C:0.00MN NA 188
    rs738606201,2
    C--127291984(+) TGGTGG/AATGCT 3 -- ut31 nc-transcript-variant2Minor allele frequency- A:0.02WA 120
    rs10435491,2
    C,F,H--127292066(-) CTTCTC/TTGCAC 3 -- ut31 nc-transcript-variantese3 trp36Minor allele frequency- T:0.00MN NS NA 756
    rs760393631,2
    C,F--127292100(+) CCAAGC/TATGGC 3 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.02EA 120
    rs1460806931,2
    --127292271(+) CCCACA/GGAACG 3 -- ut31 nc-transcript-variant0--------
    rs1131735481,2
    C,F--127292275(+) CAGAAC/GGTCCC 3 -- ut31 nc-transcript-variant2Minor allele frequency- G:0.04CSA WA 119
    rs622641131,2
    C,F--127292333(+) CTCTGG/ACCTGT 3 -- ut31 nc-transcript-variant4Minor allele frequency- A:0.10NA EA EU 1199

    HapMap Linkage Disequilibrium report for TPRA1 (127291908 - 127317094 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TPRA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv5249n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TPRA1
    DNA2.0 Custom Variant and Variant Library Synthesis for TPRA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608336    OMIM disorders: --


    Find genes that share disorders with TPRA1           About GenesLikeMe


    Export disorders for TPRA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TPRA1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with TPRA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential expression of a novel seven transmembrane domain protein in epididymal fat from aged and diabetic mice. (PubMed id 10342878)1, 2, 3 Yang H.... Montrose-Rafizadeh C. (Endocrinology 1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    7. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    8. Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. (PubMed id 16806233)1 Ma J....Liew C.C. (Atherosclerosis 2007)
    9. Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling. (PubMed id 17255364)1 Lapierre L.A....Goldenring J.R. (Am. J. Physiol. Gastrointest. Liver Physiol. 2007)
    10. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 131601 HGNC: 30413 AceView: TPRA40 Ensembl:ENSG00000163870 euGenes: HUgn131601
    ECgene: TPRA1 H-InvDB: TPRA1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TPRA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TPRA1 gene:
    Search GeneIP for patents involving TPRA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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