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Aliases for TPRA1 Gene

Aliases for TPRA1 Gene

  • Transmembrane Protein Adipocyte Associated 1 2 3
  • Transmembrane Protein, Adipocyte Asscociated 1 2 3 5
  • Transmembrane Protein 227 2 3 4
  • Integral Membrane Protein GPR175 3 4
  • G Protein-Coupled Receptor 175 2 3
  • TMEM227 3 4
  • GPR175 3 4
  • Transmembrane Domain Protein Regulated In Adipocytes 40 KDa 3
  • Transmembrane Protein, Adipocyte Associated 1 3
  • Seven Transmembrane Domain Orphan Receptor 3
  • TPRA40 3

External Ids for TPRA1 Gene

Previous HGNC Symbols for TPRA1 Gene

  • GPR175

Previous GeneCards Identifiers for TPRA1 Gene

  • GC03M128776
  • GC03M127291
  • GC03M124672

Summaries for TPRA1 Gene

GeneCards Summary for TPRA1 Gene

TPRA1 (Transmembrane Protein Adipocyte Associated 1) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPRA1 Gene

Genomics for TPRA1 Gene

Genomic Location for TPRA1 Gene

Chromosome:
3
Start:
127,573,064 bp from pter
End:
127,598,251 bp from pter
Size:
25,188 bases
Orientation:
Minus strand

Genomic View for TPRA1 Gene

Genes around TPRA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPRA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPRA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPRA1 Gene

No data available for Regulatory Elements for TPRA1 Gene

Proteins for TPRA1 Gene

  • Protein details for TPRA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86W33-TPRA1_HUMAN
    Recommended name:
    Transmembrane protein adipocyte-associated 1
    Protein Accession:
    Q86W33
    Secondary Accessions:
    • A8MVB8
    • D3DNA9
    • Q8WZ24
    • Q96AJ6
    • Q9P2R4

    Protein attributes for TPRA1 Gene

    Size:
    373 amino acids
    Molecular mass:
    41053 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TPRA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPRA1 Gene

Proteomics data for TPRA1 Gene at MOPED

Post-translational modifications for TPRA1 Gene

  • Ubiquitination at Lys 289
  • Glycosylation at Asn 11, Asn 23, and Asn 361
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TPRA1 Gene

Domains & Families for TPRA1 Gene

Gene Families for TPRA1 Gene

Protein Domains for TPRA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TPRA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86W33

UniProtKB/Swiss-Prot:

TPRA1_HUMAN :
  • Belongs to the UPF0359 family.
Family:
  • Belongs to the UPF0359 family.
genes like me logo Genes that share domains with TPRA1: view

Function for TPRA1 Gene

genes like me logo Genes that share phenotypes with TPRA1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TPRA1

CRISPR Products

miRNA for TPRA1 Gene

miRTarBase miRNAs that target TPRA1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPRA1 Gene

Localization for TPRA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPRA1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPRA1 Gene COMPARTMENTS Subcellular localization image for TPRA1 gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for TPRA1 Gene

Pathways & Interactions for TPRA1 Gene

SuperPathways for TPRA1 Gene

No Data Available

Interacting Proteins for TPRA1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000347748%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000262623%0d%0a
Selected Interacting proteins: ENSP00000347748 for TPRA1 Gene via STRING

Gene Ontology (GO) - Biological Process for TPRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 10342878
GO:0007186 G-protein coupled receptor signaling pathway TAS 10342878
GO:1901991 negative regulation of mitotic cell cycle phase transition IEA --
genes like me logo Genes that share ontologies with TPRA1: view

No data available for Pathways by source and SIGNOR curated interactions for TPRA1 Gene

Drugs & Compounds for TPRA1 Gene

No Compound Related Data Available

Transcripts for TPRA1 Gene

Unigene Clusters for TPRA1 Gene

Transmembrane protein, adipocyte asscociated 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPRA1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - -
SP6: -
SP7: -
SP8:

Relevant External Links for TPRA1 Gene

GeneLoc Exon Structure for
TPRA1
ECgene alternative splicing isoforms for
TPRA1

Expression for TPRA1 Gene

mRNA expression in normal human tissues for TPRA1 Gene

Protein differential expression in normal tissues from HIPED for TPRA1 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TPRA1 Gene



SOURCE GeneReport for Unigene cluster for TPRA1 Gene Hs.6418

mRNA Expression by UniProt/SwissProt for TPRA1 Gene

Q86W33-TPRA1_HUMAN
Tissue specificity: Ubiquitous, with higher levels in heart, placenta and kidney.
genes like me logo Genes that share expression patterns with TPRA1: view

Protein tissue co-expression partners for TPRA1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TPRA1 Gene

Orthologs for TPRA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPRA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPRA1 36
  • 100 (a)
OneToOne
TPRA1 35
  • 99.91 (n)
  • 99.73 (a)
cow
(Bos Taurus)
Mammalia TPRA1 35
  • 88.4 (n)
  • 93.67 (a)
TPRA1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPRA1 36
  • 96 (a)
OneToOne
TPRA1 35
  • 91.39 (n)
  • 96.15 (a)
mouse
(Mus musculus)
Mammalia Tpra1 16
Tpra1 36
  • 92 (a)
OneToOne
Tpra1 35
  • 86.99 (n)
  • 92.41 (a)
oppossum
(Monodelphis domestica)
Mammalia TPRA1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TPRA1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tpra1 35
  • 86.63 (n)
  • 91.87 (a)
chicken
(Gallus gallus)
Aves TPRA1 35
  • 77.78 (n)
  • 87.74 (a)
TPRA1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TPRA1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17655 35
tpra1 35
  • 74.02 (n)
  • 80.29 (a)
zebrafish
(Danio rerio)
Actinopterygii tpra1 36
  • 72 (a)
OneToOne
tpra1 35
  • 72.05 (n)
  • 77.34 (a)
wufc75f12 35
worm
(Caenorhabditis elegans)
Secernentea tpra-1 35
  • 44.92 (n)
  • 37.28 (a)
tpra-1 36
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToOne
Species with no ortholog for TPRA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPRA1 Gene

ENSEMBL:
Gene Tree for TPRA1 (if available)
TreeFam:
Gene Tree for TPRA1 (if available)

Paralogs for TPRA1 Gene

No data available for Paralogs for TPRA1 Gene

Variants for TPRA1 Gene

Sequence variations from dbSNP and Humsavar for TPRA1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs920230 -- 127,586,114(+) CCTCA(C/T)GGGGG intron-variant, upstream-variant-2KB
rs1043549 -- 127,573,223(+) CTTCT(A/C/G/T)TGCAC nc-transcript-variant, utr-variant-3-prime
rs1043554 -- 127,573,139(+) CATCC(A/C/G/T)CCATG nc-transcript-variant, utr-variant-3-prime
rs2720269 -- 127,592,355(-) TTGCT(C/T)CACAC intron-variant, upstream-variant-2KB
rs6439080 -- 127,582,498(+) gagtt(C/T)aagac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPRA1 Gene

Variant ID Type Subtype PubMed ID
dgv5249n71 CNV Loss 21882294

Variation tolerance for TPRA1 Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPRA1 Gene

HapMap Linkage Disequilibrium report
TPRA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPRA1 Gene

Disorders for TPRA1 Gene

Relevant External Links for TPRA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPRA1

No disorders were found for TPRA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPRA1 Gene

Publications for TPRA1 Gene

  1. Differential expression of a novel seven transmembrane domain protein in epididymal fat from aged and diabetic mice. (PMID: 10342878) Yang H. … Montrose-Rafizadeh C. (Endocrinology 1999) 2 3 4 67
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  3. Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. (PMID: 16806233) Ma J. … Liew C.C. (Atherosclerosis 2007) 3
  4. Cloning and characterization of an orphan seven transmembrane receptor from Schistosoma mansoni. (PMID: 17714602) Pearson M.S. … Loukas A. (Parasitology 2007) 23
  5. Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling. (PMID: 17255364) Lapierre L.A. … Goldenring J.R. (Am. J. Physiol. Gastrointest. Liver Physiol. 2007) 3

Products for TPRA1 Gene

Sources for TPRA1 Gene

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