TPRA1 Gene
protein-coding GIFtS: 43
GCID: GC03M127291
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|
transmembrane protein, adipocyte asscociated 1(Previous name: G protein-coupled receptor 175 )
(Previous symbol: GPR175)
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Aliases
for TPRA1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein, Adipocyte Asscociated 11 2 | | Transmembrane Protein 2272 3 | | GPR1751 2 3 | | FLJ321971 | | TMEM2271 2 3 | | Seven Transmembrane Domain Orphan Receptor2 | | TPRA401 2 | | Transmembrane Domain Protein Regulated In Adipocytes 40 KDa2 | | G Protein-Coupled Receptor 1751 2 | | Transmembrane Protein Adipocyte-Associated 12 | | Integral Membrane Protein GPR1752 3 | | Transmembrane Protein, Adipocyte Associated 12 |
Export aliases for TPRA1 gene to outside databasesPrevious GC identifers: GC03M128776 GC03M124672 |
Summaries
for TPRA1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TPRA1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TPRA1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TPRA1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPRA1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q21.2 Ensembl cytogenetic band: 3q21.3 HGNC cytogenetic band: 3q21.2TPRA1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M127291: view genomic region
(about GC identifiers)
Start:
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127,291,908 bp from pter |
End:
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127,317,094 bp from pter |
Size:
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25,187 bases |
Orientation:
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minus strand |
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Proteins
for TPRA1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TPRA1_HUMAN, Q86W33 (See
protein sequence)Recommended Name: Transmembrane protein adipocyte-associated 1 Size: 373 amino acids; 41053 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: A8MVB8 D3DNA9 Q8WZ24 Q96AJ6 Q9P2R4Alternative splicing: 3 isoforms: Q86W33-1 Q86W33-2 Q86W33-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TPRA1: NX_Q86W33
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86W33
TPRA1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_057456.2 NP_001129525.1 NP_001136118.1
ENSEMBL proteins: ENSP00000413428 ENSP00000296210 ENSP00000347748 ENSP00000377056 ENSP00000418827 ENSP00000418298 ENSP00000417113 ENSP00000419533 ENSP00000419822 ENSP00000419299
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TPRA1 for ontologies About GeneDecksing
TPRA1 Antibody Products:
Assay Products for TPRA1: |
Protein
Domains /
Families
for TPRA1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TPRA1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q86W33ProtoNet protein and cluster: Q86W33 UniProtKB/Swiss-Prot: TPRA1_HUMAN, Q86W33Similarity: Belongs to the UPF0359 family |
Function
for TPRA1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPRA1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPRA1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): TPRA1 (NM_001142646) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TPRA1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPRA1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPRA1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
TAS | 10342878 |
TPRA1 for ontologies About GeneDecksing
Animal Models:
1 MGI phenotypic allele  for Tpra1 (no phenotypes)
TPRA1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TPRA1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TPRA1
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
TPRA1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TPRA1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TPRA1
Search CenterWatch for drugs/clinical trials and news about TPRA1
|
Transcripts
for TPRA1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TPRA1 gene (3 alternative transcripts): NM_016372.2 NM_001136053.2 NM_001142646.2 Unigene Cluster for TPRA1: Transmembrane protein, adipocyte asscociated 1 Hs.6418 [show with all ESTs]Unigene Representative Sequence: NM_00113605311 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000450633(uc003ejl.2) ENST00000296210(uc010hsk.2) ENST00000355552(uc003ejn.2 uc003ejm.3)
ENST00000393400 ENST00000483868 ENST00000489960 ENST00000465915 ENST00000490290
ENST00000469111 ENST00000490643 ENST00000462228
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPRA1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPRA1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): TPRA1 (NM_001142646) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TPRA1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPRA1 |
Additional cDNA sequence: AB037108.1 AF289568.1 BC017058.1 BC050711.2 NR_073377.1 15 DOTS entries: DT.95344734 DT.97801190 DT.441917 DT.91762792 DT.100769628 DT.95344763 DT.100845188 DT.95344758 DT.100834837 DT.120846985 DT.100711872 DT.120846972 DT.95176232 DT.91643520 DT.95344744 24/204 AceView cDNA sequences (see all 204): CB995484 BM708201 BI759559 BQ021809 AF289568 CA447809 CR612256 BI090259 CA449451 BQ014454 BU071293 AI362259 BU556802 BX381599 AI272936 BU556867 CR617620 BF805285 BI761996 BI488847 BU540773 AW403875 CB530000 CB121256
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TPRA1 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14a | · | 14b |
|---|
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| SP1: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP4: | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | | | - | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TPRA1
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Expression
for TPRA1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TPRA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGATGGAC
About this image
See TPRA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TPRA1
SOURCE GeneReport for Unigene cluster: Hs.6418
UniProtKB/Swiss-Prot: TPRA1_HUMAN, Q86W33Tissue specificity: Ubiquitous, with higher levels in heart, placenta and kidney
SABiosciences Custom PCR Arrays for TPRA1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TPRA1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TPRA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPRA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPRA1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPRA1 |
Orthologs
for TPRA1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TPRA1 gene from 9/20 species (see all 20) About this table
ENSEMBL Gene Tree for TPRA1 (if available)
TreeFam Gene Tree for TPRA1 (if available) |
Paralogs
for TPRA1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TPRA1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TPRA1 (127291908 - 127317094 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TPRA1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPRA1 |
|
Disorders
/ Diseases
for TPRA1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TPRA1 for disorders About GeneDecksing
OMIM gene information: 608336
OMIM disorders: --
3  diseases for TPRA1: About MalaCardsepididymitis hypoxia immunodeficiency
Export disorders for TPRA1 gene to outside databases
|
Publications
for TPRA1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TPRA1 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with TPRA1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Differential expression of a novel seven transmembrane domain protein in epididymal fat from aged and diabetic mice. (PubMed id 10342878)1, 2, 3 Yang H.... Montrose-Rafizadeh C. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. (PubMed id 16806233)1 Ma J....Liew C.C. (2007)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)2 Wan D....Gu J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for TPRA1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TPRA1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TPRA1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TPRA1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TPRA1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TPRA1 gene:
Search GeneIP for patents involving TPRA1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TPRA1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TPRA1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TPRA1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TPRA1 | | | OriGene Protein Over-expression Lysate for TPRA1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TPRA1 | | OriGene 3'-UTR Clone for TPRA1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPRA1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPRA1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TPRA1 | | OriGene Custom Protein Services for TPRA1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TPRA1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPRA1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPRA1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TPRA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPRA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPRA1 |
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| | | | Search Tocris compounds for TPRA1 |
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 | | | TPRA1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPRA1 |
|  |  |  | | | | ThermoFisher Antibodies for TPRA1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPRA1 |
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