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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TPR Gene

protein-coding   GIFtS: 65
GCID: GC01M186282

Translocated Promoter Region, Nuclear Basket Protein

(Previous name: translocated promoter region (to activated MET oncogene))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Translocated Promoter Region, Nuclear Basket Protein1 2     Nuclear Pore Complex-Associated Protein TPR2
Translocated Promoter Region (To Activated MET Oncogene)1 2     Nucleoprotein TPR2
Translocated Promoter Region Protein2 3     Tumor Potentiating Region2
NPC-Associated Intranuclear Protein2 3     Megator3
megator2     

External Ids:    HGNC: 120171   Entrez Gene: 71752   Ensembl: ENSG000000474107   OMIM: 1899405   UniProtKB: P122703   

Export aliases for TPR gene to outside databases

Previous GC identifers: GC01M183808 GC01M181710 GC01M182802 GC01M183521 GC01M183014 GC01M184549 GC01M186281 GC01M157517


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TPR Gene:
This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of
nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required
for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several
different kinase genes occur in some neoplasias. (provided by RefSeq, Jul 2008)

GeneCards Summary for TPR Gene: 
TPR (translocated promoter region, nuclear basket protein) is a protein-coding gene. Diseases associated with TPR include pediatric ependymoma, and syphilis, and among its related super-pathways are Interactions of Rev with host cellular proteins and HIV Life Cycle. GO annotations related to this gene include transporter activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: TPR_HUMAN, P12270
Function: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear
envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal
nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral
chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis.
Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153,
regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1-
and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large
polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of
unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates
both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced
conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as
a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role
in the regulation of nuclear protein export (PubMed:22253824 and PubMed:11952838). Plays also a role as a
structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or
maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial
regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of
spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase
transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TPR gene promoter:
         GR   GR-beta   Olf-1   STAT5A   GR-alpha   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TPR promoter sequence
   Search SABiosciences Chromatin IP Primers for TPR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q31.1   HGNC cytogenetic band: 1q25

TPR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPR gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M186282:  view genomic region     (about GC identifiers)

Start:
186,280,784 bp from pter      End:
186,344,825 bp from pter
Size:
64,042 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TPR_HUMAN, P12270 (See protein sequence)
Recommended Name: Nucleoprotein TPR  
Size: 2363 amino acids; 267293 Da
Subunit: Interacts with IFI204 (via C-terminus region). Interacts with IFI203 (By similarity). Homodimer. Part of
the nuclear pore complex (NPC). Associates with the XPO1/CRM1-mediated nuclear export complex, the Importin
alpha/Importin beta receptor and the dynein 1 complex. Interacts (via C-terminus domain) with the KPNB1; the
interaction occurs in a RanGTP-dependent manner. Interacts (via C-terminus region and phosphorylated form) with
MAPK1/ERK2 (via phosphorylated form); the interaction requires dimerization of MAPK1/ERK2 and increases following
EGF stimulation. Interacts with MAPK3/ERK1; the interaction increases following EGF stimulation. Interacts (via
coiled coil region) with NUP153; the interaction is direct. Interacts with HSF1; the interaction increases in a
stress-responsive manner and stimulates export of stress-induced HSP70 mRNA. Interacts with huntingtin/HTT; the
interaction is inhibited by aggregated huntingtin/HTT forms with expanded polyglutamine stretch. Interacts with
MAD1L1 (via N-terminus region), MAD2L1, and TTK; the interactions occurs in a microtubule-independent manner.
Interacts (via middle region) with DYNLL1. Interacts with DCTN1, dynein, NUP153 and tubulin
Subcellular location: Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus
envelope. Nucleus, nuclear pore complex. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere,
kinetochore. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected as discrete
intranuclear foci with IFI204 (By similarity). In interphase, localizes to the nucleoplasmic side of the nuclear
pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Detected exclusively to
the cytoplasmic margin of NPC (PubMed:7798308). Docking to the inner nucleoplasmic side of the NPC is mediated
through binding to nucleoporins. Anchored by NUP153 to the NPC. The assembly of the NPC is a stepwise process in
which Trp-containing peripheral structures assemble after other components, including p62. Detected as filaments
that emanate from the nuclear basket of the NPC and extend to the nucleolus to delineate a chromatin-free network
extending from the nuclear envelope to the perinucleolar region. Detected in diffuse and discrete spheroidal
intranuclear foci. Nucleocytoplasmic shuttling protein imported into the nucleus in a XPO1/CRM1- and Importin
alpha/Importin beta receptor-dependent manner. Remains localized to the nuclear membrane after poliovirus (PV)
infection. During mitosis, remains associated with the nuclear envelope until prometaphase. Associated with the
mitotic spindle from late prometaphase until anaphase. Reorganized during mitosis in a viscous and dynamic
nuclear-derived spindle matrix that embeds the microtubule spindle apparatus from pole to pole in a
microtubule-independent manner. Recruited to the reforming nuclear envelope during telophase and cytokinesis.
Detected at kinetochores during prometaphase (PubMed:18981471). Colocalizes with MAD2L1 in the spindle matrix but
not at kinetochore (PubMed:19273613). Colocalizes with dynein, dynactin, tubulin at kinetochore during the
metaphase-anaphase transition. Colocalizes with DYNLL1 at the mitotic spindle
Secondary accessions: Q15655 Q5SWY0 Q99968

Explore the universe of human proteins at neXtProt for TPR: NX_P12270

Explore proteomics data for TPR at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylation occurs on serine and threonine residues (comprised in the C-terminus region) by
    MAPK1/ERK2 and stabilizes the interaction between these two proteins
  • UniProtKB: Proteolytically degraded after poliovirus (PV) infection; degradation is restricted to its unfolded C-terminal
    tail domain whereas its coiled-coil domain containing NCP- and NUP153-binding domains withstand degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P12270

  • TPR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TPR Protein Expression
    REFSEQ proteins: NP_003283.2  
    ENSEMBL proteins: 
     ENSP00000356448   ENSP00000408103  
    Reactome Protein details: P12270
    Human Recombinant Protein Products for TPR: 
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    Novus Biologicals TPR Protein
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TPR 

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776colocalizes with kinetochore IDA18981471
    GO:0005634nucleus IDA15654337
    GO:0005635nuclear envelope IDA17098863
    GO:0005643nuclear pore IDA11514627
    GO:0005654nucleoplasm TAS--

    TPR for ontologies           About GeneDecksing



    TPR Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for TPR 

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    Cloud-Clone Corp. CLIAs for TPR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR009053 Prefoldin
     IPR015866 Ser-tRNA-synth_1_N
     IPR012929 TPR_MLP1_2

    Graphical View of Domain Structure for InterPro Entry P12270

    ProtoNet protein and cluster: P12270

    1 Blocks protein domain: IPB012929 Tetratricopeptide

    UniProtKB/Swiss-Prot: TPR_HUMAN, P12270
    Domain: The N-terminus domain mediates intranuclear attachment to the nuclear pore complex. The C-terminus domain
    mediates its nuclear import
    Similarity: Belongs to the TPR family


    TPR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TPR_HUMAN, P12270
    Function: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear
    envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal
    nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral
    chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis.
    Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153,
    regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1-
    and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large
    polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of
    unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates
    both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced
    conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as
    a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role
    in the regulation of nuclear protein export (PubMed:22253824 and PubMed:11952838). Plays also a role as a
    structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or
    maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial
    regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of
    spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase
    transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases

         Genatlas biochemistry entry for TPR:
    translocated promoter region,involved in several rearrangements (TPR-MET;TPR-TRKA (NTRK1),with papillary thyroid
    carcinomas)

         Gene Ontology (GO): 5/15 molecular function terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003682chromatin binding IDA17897941
    GO:0003729mRNA binding IDA17897941
    GO:0004828serine-tRNA ligase activity IEA--
    GO:0005215NOT transporter activity IMP11952838
         
    TPR for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for TPR:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased viability 
     G0/1 arrest  Increased G1 DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TPR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TPR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TPR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TPR 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TPR
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate TPR (see all 11):
    hsa-miR-3163 hsa-miR-4307 hsa-miR-3133 hsa-miR-33a* hsa-miR-186 hsa-miR-514 hsa-miR-3185 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidTPR 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): TPR (NM_001099952)
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TPR About   (see all 14)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Rev-mediated nuclear export of HIV RNA0.94
    Hexose transport0.87
    Nuclear import of Rev protein0.94
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.82
    Interactions of Rev with host cellular proteins0.94
    Nuclear Pore Complex (NPC) Disassembly0.77
    Vpr-mediated nuclear import of PICs0.91
    Nuclear Envelope Breakdown0.77
    2HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    Host Interactions of HIV factors0.60
    3Interferon Signaling
    Interferon Signaling0.61
    Antiviral mechanism by IFN-stimulated genes0.42
    Cytokine Signaling in Immune system0.61
    ISG15 antiviral mechanism0.42
    4M Phase
    M Phase0.88
    Mitotic M-M/G1 phases0.88
    5Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TPR
        Integrated Breast Cancer Pathway

    5/29        Reactome Pathways for TPR (see all 29)
        Antiviral mechanism by IFN-stimulated genes
    Late Phase of HIV Life Cycle
    Metabolism
    Cell Cycle
    M Phase


    3         Kegg Pathways  (Kegg details for TPR):
        RNA transport
    Pathways in cancer
    Thyroid cancer


    TPR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TPR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/628 Interacting proteins for TPR (P122702, 3 ENSP000003564484) via UniProtKB, MINT, STRING, and/or I2D (see all 628)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUP107P577402, 3, ENSP000002291794MINT-7947479 I2D: score=1 STRING: ENSP00000229179
    EXOC7Q9UPT52, 3MINT-7947479 I2D: score=1 
    NFKB1P198382, 3MINT-48545 I2D: score=1 
    NUP93Q8N1F72, 3, ENSP000003106684MINT-7947479 I2D: score=1 STRING: ENSP00000310668
    SHC1P293532, 3, ENSP000004013034MINT-7947479 I2D: score=1 STRING: ENSP00000401303
    About this table

    Gene Ontology (GO): 5/41 biological process terms (GO ID links to tree view) (see all 41):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--
    GO:0000189MAPK import into nucleus IMP18794356
    GO:0000278mitotic cell cycle TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006308DNA catabolic process ----

    TPR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TPR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TPR

    4 DrugBank Compounds for TPR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Flavin-Adenine Dinucleotide-- 146-14-5target--17139284 17016423
    Maleic Acid-- 110-16-7target--17139284 17016423
    N-{(1s)-4-[Bis(2-Chloroethyl)Amino]-1-Methylbutyl}-N-(6-Chloro-2-Methoxy-9-Acridinyl)Amine-- --target--17139284 17016423
    Trypanothione-- --target--17139284 17016423

    2 Novoseek inferred chemical compound relationships for TPR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 33.4 3 8208547 (1), 1532241 (1), 8413267 (1)
    leucine 30.7 2 8413267 (2)

    Search CenterWatch for drugs/clinical trials and news about TPR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TPR gene: 
    NM_003292.2  

    Unigene Cluster for TPR:

    Translocated promoter region, nuclear basket protein
    Hs.279640  [show with all ESTs]
    Unigene Representative Sequence: NM_003292
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367478(uc001grv.3) ENST00000467810 ENST00000492973 ENST00000481347
    ENST00000491783 ENST00000469463 ENST00000474852(uc010pop.2) ENST00000451586

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK309473.1 BC016514.1 BC025177.1 BC094764.1 U69668.1 X66397.1 Y00672.1 

    20 DOTS entries:

    DT.100036341  DT.448411  DT.101980758  DT.100036340  DT.91758582  DT.420686  DT.97777854  DT.100883668 
    DT.121407514  DT.97786794  DT.121407507  DT.314769  DT.91758574  DT.97859618  DT.121407524  DT.100036339 
    DT.121407469  DT.40132820  DT.99947504  DT.100751817 

    24/302 AceView cDNA sequences (see all 302):

    AI401345 AI990460 AW847833 BE819011 AA555031 BQ001036 AW070759 BU623264 
    AA454176 AA448223 AA448376 AA970275 BC016514 BE819001 BM510070 BM794059 
    AA953881 BC025177 CA841085 AU140228 AU130786 BU165277 AL120958 CB158772 

    GeneLoc Exon Structure

    5/23 Alternative Splicing Database (ASD) splice patterns (SP) for TPR (see all 23)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                      -                     

    ExUns: 21a · 21b ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b · 24c ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b · 27c ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b ^ 31 ^ 32 ^ 33 ^ 34a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 34b · 34c ^ 35 ^ 36a · 36b · 36c ^ 37 ^ 38a · 38b ^ 39a · 39b · 39c ^ 40a · 40b ^ 41a · 41b ^ 42a · 42b ^ 43a · 43b ^ 44a · 44b ^ 45a · 45b · 45c ^ 46 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                  -     -   
    SP4:                                                                                                                                                  -     -   
    SP5:                                                                                                                                                            

    ExUns: 47 ^ 48 ^ 49 ^ 50 ^ 51 ^ 52 ^
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for TPR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TPR expression in normal human tissues (normalized intensities)      TPR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAATATTCT
    TPR Expression
    About this image


    TPR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Breast
             breast ; myoepithelial cells   
             breast ductal cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See TPR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TPR

    SOURCE GeneReport for Unigene cluster: Hs.279640

    UniProtKB/Swiss-Prot: TPR_HUMAN, P12270
    Tissue specificity: Expressed in esophagus, ovary, liver, skin, smooth muscles, cerebrum and fetal cerebellum (at
    protein level). Highest in testis, lung, thymus, spleen and brain, lower levels in heart, liver and kidney

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TPR gene from 8/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tpr1 , 5 translocated promoter region1, 5 88.36(n)1
    94.1(a)1
      1 (63.84 cM)5
    1089891  NM_133780.31  NP_598541.31 
     1503928385 
    chicken
    (Gallus gallus)
    Aves TPR1 translocated promoter region (to activated MET oncogene) 78.69(n)
    84.05(a)
      424457  XM_422300.2  XP_422300.2 
    lizard
    (Anolis carolinensis)
    Reptilia TPR6
    Uncharacterized protein
    79(a)
    1 ↔ 1
    GL343203.1(2433509-2499533)
    African clawed frog
    (Xenopus laevis)
    Amphibia tpr2 tpr protein 75.03(n)    U69669.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.26552 Transcribed sequence with weak similarity to protein more 70.66(n)    57069817 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mtor1 , 3 Megator1 23(a)3
    40.14(n)1
    26.92(a)1
      48C53
    362641  NM_057719.31  NP_477067.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MLP1(YKR095W)4
    MLP11
    Myosin-like protein associated with the nuclear envelope, more4
    Mlp1p1
    41.54(n)1
    24.11(a)1
      11(619805-625432)4
    8539701, 4  NP_013021.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NUA1 nucleoprotein TPR 40.38(n)
    24.87(a)
      844268  NM_001198507.1  NP_001185436.1 


    ENSEMBL Gene Tree for TPR (if available)
    TreeFam Gene Tree for TPR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TPR gene
    1 SIMAP similar gene for TPR using alignment to 6 protein entries:     TPR_HUMAN (see all proteins):
    Tpr

    TPR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1483 SNPs in TPR are shown (see all 1483)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1852577461,2
    --157530718(+) TATAAC/TATATA 1 -- int10--------
    rs2003365361,2
    C--186284338(+) AAAAA-/ACAAAC 1 -- int10--------
    rs57792841,2
    C--186296277(+) tatat-/Aaatat 1 -- int10--------
    rs741856121,2
    C--186296325(-) TATAA-/TATATA 1 -- int12Minor allele frequency- T:0.00NA 4
    rs673424521,2
    C--186296395(-) ATATA-/TA    
       TT
    /TT
    ATATA
    1 -- int11NA 2
    rs3677139211,2
    C--186296413(+) ATATA-/AATATA 1 -- int10--------
    rs798185981,2
    C--186308526(+) GACTT-/AC    
       T
    /CTA
    CTGAG
    2 -- cds11CSA 2
    rs677674941,2
    C--186308527(+) ACTTC-/ACT   
      
    /CTA/T
    TGAGT
    3 -- int1 cds10--------
    rs600862131,2
    C--186308528(+) CTTCTACT/-GAGTA 1 -- cds11Minor allele frequency- -:0.00NA 2
    rs680917131,2
    C--186311466(+) TAAGG-/ATTGGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TPR (186280784 - 186344825 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TPR:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2528820CNV Deletion19546169
    nsv523794CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 189940    OMIM disorders: --

    UniProtKB/Swiss-Prot: TPR_HUMAN, P12270
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an
    irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm
    characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered
    with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry is involved in
    disease pathogenesis. A chromosomal aberration involving TPR has been found in thyroid papillary carcinomas.
    Intrachromosomal rearrangement that links the 5'-end of the TPR gene to the protein kinase domain of NTRK1 forms
    the fusion protein TRK-T1. TRK-T1 is a 55 kDa protein reacting with antibodies against the carboxy terminus of
    the NTRK1 protein
  • Note=Involved in tumorigenic rearrangements with the MET or RAF genes

  • 13 diseases for TPR:    About MalaCards
    pediatric ependymoma    syphilis    ependymoma    papillary carcinoma
    papillary thyroid carcinoma    thyroid cancer    thyroiditis    influenza
    hepatitis b    hepatitis    prostate cancer    prostatitis
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for TPR:
    Syphilis

    TPR for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TPR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid papillary carcinoma 63.3 1 1532241 (1)
    tumors 0 1 19577736 (1)

    Human Genome Epidemiology (HuGE) Navigator: TPR (5 documents)
    Tumor Gene Database (TGDB): TPR

    Export disorders for TPR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TPR gene, integrated from 9 sources (see all 95):
    (articles sorted by number of sources associating them with TPR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. (PubMed id 15229283)1, 2, 3, 9 Krull S....Cordes V.C. (2004)
    2. Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. (PubMed id 18794356)1, 2, 9 Vomastek T....Nandicoori V.K. (2008)
    3. TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas. (PubMed id 1532241)1, 2, 9 Greco A....Della Porta G. (1992)
    4. Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments. (PubMed id 9024684)1, 2, 9 Cordes V.C.... Franke W.W. (1997)
    5. Localization of nucleoporin Tpr to the nuclear pore co mplex is essential for Tpr mediated regulation of the export of unspliced RNA. (PubMed id 22253824)1, 2 Rajanala K. and Nandicoori V.K. (2012)
    6. The Tpr protein regulates export of mRNAs with retain ed introns that traffic through the Nxf1 pathway. (PubMed id 21613532)1, 2 Coyle J.H....Hammarskjold M.L. (2011)
    7. Protein Tpr is required for establishing nuclear pore -associated zones of heterochromatin exclusion. (PubMed id 20407419)1, 2 Krull S....Cordes V.C. (2010)
    8. Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator. (PubMed id 19273613)1, 2 Lince-Faria M....Maiato H. (2009)
    9. Tpr directly binds to Mad1 and Mad2 and is important for the Mad1- Mad2-mediated mitotic spindle checkpoint. (PubMed id 18981471)1, 2 Lee S.H.... McCormick F. (2008)
    10. HSF1-TPR interaction facilitates export of stress-induced HSP70 mRNA. (PubMed id 17897941)1, 2 Skaggs H.S....Sarge K.D. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7175 HGNC: 12017 AceView: TPR Ensembl:ENSG00000047410 euGenes: HUgn7175
    ECgene: TPR Kegg: 7175 H-InvDB: TPR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TPR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TPR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TPR gene:
    Search GeneIP for patents involving TPR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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