TPR Gene
protein-coding GIFtS: 63
GCID: GC01M186282
|
|
translocated promoter region, nuclear basket protein(Previous name: translocated promoter region (to activated MET oncogene)...)
| |
Aliases
for TPR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Translocated Promoter Region, Nuclear Basket Protein1 2 | | Translocated Promoter Region (To Activated MET Oncogene)1 2 | | Nuclear Pore Complex-Associated Protein TPR2 | | Nucleoprotein TPR2 | | Tumor Potentiating Region2 |
Export aliases for TPR gene to outside databasesPrevious GC identifers: GC01M183808 GC01M181710 GC01M182802 GC01M183521 GC01M183014 GC01M184549 GC01M186281 GC01M157517 |
Summaries
for TPR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TPR:
This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface ofnuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required forthe nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several differentkinase genes occur in some neoplasias. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TPR_HUMAN, P12270Function: Component of the cytoplasmic fibrils of the nuclear pore complex implicated in nuclear protein import. ItsN-terminus is involved in activation of oncogenic kinases. Plays a role in the mitotic spindle checkpoint
|
Genomic Views
for TPR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TPR gene promoter:
GR GR-beta Olf-1 STAT5A GR-alpha Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for TPR
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPR |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q25 Ensembl cytogenetic band: 1q31.1 HGNC cytogenetic band: 1q25TPR Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M186282: view genomic region
(about GC identifiers)
Start:
|
186,280,784 bp from pter |
End:
|
186,344,825 bp from pter |
Size:
|
64,042 bases |
Orientation:
|
minus strand |
|
Proteins
for TPR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TPR_HUMAN, P12270 (See
protein sequence)Recommended Name: Nucleoprotein TPR Size: 2363 amino acids; 267293 Da
Subunit: Interacts with MAD1L1 and MAD2L1
Subcellular location: Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side.Chromosome, centromere, kinetochore. Note=The assembly of the NPC is a stepwise process in which Trp-containingperipheral structures assemble after other components, including p62. Detected at kinetochores during prometaphase
Secondary accessions: Q15655 Q5SWY0Explore the universe of human proteins at neXtProt for TPR: NX_P12270
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P12270
TPR Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003283.2
ENSEMBL proteins: ENSP00000356448 ENSP00000408103 Reactome Protein details: P12270
Human Recombinant Protein Products:
Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12): About this table
TPR for ontologies About GeneDecksing
TPR Antibody Products:
Assay Products for TPR: |
Protein
Domains /
Families
for TPR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TPR for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P12270ProtoNet protein and cluster: P12270 1 Blocks protein family: IPB012929 Tetratricopeptide
|
Function
for TPR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TPR_HUMAN, P12270Function: Component of the cytoplasmic fibrils of the nuclear pore complex implicated in nuclear protein import. ItsN-terminus is involved in activation of oncogenic kinases. Plays a role in the mitotic spindle checkpoint Genatlas biochemistry entry for TPR:translocated promoter region,involved in several rearrangements (TPR-MET;TPR-TRKA (NTRK1),with papillary thyroidcarcinomas)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPR (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPR
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): TPR (NM_001099952) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TPR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPR |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPR |
Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table
TPR for ontologies About GeneDecksing
7 GenomeRNAi human phenotypes for TPR:
|
Pathways & Interactions
for TPR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus | | | 2 | Cytokine Signaling in Immune system | | | 3 | HIV Infection | | | 4 | SLC-mediated transmembrane transport | | | 5 | Late Phase of HIV Life Cycle | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for TPR
5/23 
Reactome Pathways for TPR (see all 23)
3 
Kegg Pathways (Kegg details for TPR):
TPR for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TPR
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/601 Interacting proteins for TPR (P122702, 3 ENSP000003564484) via UniProtKB, MINT, STRING, and/or I2D (see all 601)About this table
Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36): About this table
TPR for ontologies About GeneDecksing
|
Drugs & Compounds
for TPR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TPR for compounds About GeneDecksing
 Browse Tocris compounds for TPR
4 DrugBank Compounds for TPR About this table
2 Novoseek chemical compound relationships for TPR gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
33.4 |
3 |
8208547 (1), 1532241 (1), 8413267 (1) |
| leucine |
30.7 |
2 |
8413267 (2) |
Search CenterWatch for drugs/clinical trials and news about TPR
|
Transcripts
for TPR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TPR gene: NM_003292.2 Unigene Cluster for TPR: Translocated promoter region, nuclear basket protein Hs.279640 [show with all ESTs]Unigene Representative Sequence: NM_0032928 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367478(uc001grv.3) ENST00000467810 ENST00000492973 ENST00000481347
ENST00000491783 ENST00000469463 ENST00000474852(uc010pop.2) ENST00000451586
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPR (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPR
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): TPR (NM_001099952) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TPR | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPR |
Additional cDNA sequence: AK309473.1 BC016514.1 BC025177.1 BC094764.1 U69668.1 X66397.1 Y00672.1 19 DOTS entries: DT.100036341 DT.448411 DT.101980758 DT.100036340 DT.91758582 DT.420686 DT.97777854 DT.100883668 DT.121407514 DT.97786794 DT.121407507 DT.314769 DT.97859618 DT.121407524 DT.100036339 DT.121407469 DT.40132820 DT.91758574 DT.99947504 24/302 AceView cDNA sequences (see all 302): BU616398 AI766217 BQ001036 BP365945 AI401345 BQ574884 BU949922 AW070759 AU140228 BC025177 AA884391 BM989816 BE819001 AI783716 BF115024 N79034 AA416958 AA319483 AI918571 AA501993 BM503924 CD687263 AA448366 AI990460
GeneLoc Exon Structure
5/23 Alternative Splicing Database (ASD) splice patterns (SP) for TPR (see all 23) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | · | 19c | ^ | 20 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | |
| ExUns: | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | · | 23c | ^ | 24a | · | 24b | · | 24c | ^ | 25a | · | 25b | ^ | 26a | · | 26b | ^ | 27a | · | 27b | · | 27c | ^ | 28a | · | 28b | ^ | 29a | · | 29b | ^ | 30a | · | 30b | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 34b | · | 34c | ^ | 35 | ^ | 36a | · | 36b | · | 36c | ^ | 37 | ^ | 38a | · | 38b | ^ | 39a | · | 39b | · | 39c | ^ | 40a | · | 40b | ^ | 41a | · | 41b | ^ | 42a | · | 42b | ^ | 43a | · | 43b | ^ | 44a | · | 44b | ^ | 45a | · | 45b | · | 45c | ^ | 46 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 47 | ^ | 48 | ^ | 49 | ^ | 50 | ^ | 51 | ^ | 52 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TPR
|
Expression
for TPR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TPR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAATATTCT
About this image
See TPR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TPR
SOURCE GeneReport for Unigene cluster: Hs.279640
UniProtKB/Swiss-Prot: TPR_HUMAN, P12270Tissue specificity: Highest in testis, lung, thymus, spleen and brain, lower levels in heart, liver and kidney
SABiosciences Custom PCR Arrays for TPR
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TPR
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TPR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPR | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPR |
Orthologs
for TPR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TPR gene from 9/31 species (see all 31) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TPR1 |
translocated promoter region (to activated MET oncogene) |
78.69(n)
84.05(a) |
|
424457 XM_422300.2 XP_422300.2 |
lizard
(Anolis carolinensis) |
Reptilia |
TPR6 |
-- |
80(a) |
1 ↔ 1 |
GL343203.1(2434529-2499533) |
African clawed frog
(Xenopus laevis) |
Amphibia |
tpr2 |
tpr protein |
75.03(n) |
|
U69669.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.26552 |
Transcribed sequence with weak similarity to protein more |
70.66(n) |
|
57069817 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Mtor1 , 3 |
Megator1 |
23(a)3
40.14(n)1
26.92(a)1 |
|
48C53
362641 NM_057719.31 NP_477067.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
R07G3.3b3 |
-- |
20(a)
(best of 2) |
|
II(7599584-7607762) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
MLP1(YKR095W)4
MLP11 |
Myosin-like protein associated with the nuclear envelope, more4
Mlp1p1 |
41.54(n)1
24.11(a)1 |
|
11(619805-625432)4
8539701, 4 NP_013021.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
NUA1 |
nucleoprotein TPR |
40.38(n)
24.87(a) |
|
844268 NM_001198507.1 NP_001185436.1 |
rice
(Oryza sativa) |
Liliopsida |
-- |
nuclear-pore anchor, putative, expressed |
9(a) |
possible ortholog |
2(31003292-31017324) |
ENSEMBL Gene Tree for TPR (if available)
TreeFam Gene Tree for TPR (if available) |
Paralogs
for TPR gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TPR gene
- CEP2902
2 SIMAP similar genes for TPR using alignment to 6 protein entries: TPR_HUMAN (see all proteins):Tpr tpr
TPR for paralogs About GeneDecksing
|
Genomic Variants
for TPR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TPR (186280784 - 186344825 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TPR
1 CNV: 97586 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPR |
|
Disorders
/ Diseases
for TPR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TPR for disorders About GeneDecksing
OMIM gene information: 189940
OMIM disorders: --
UniProtKB/Swiss-Prot: TPR_HUMAN, P12270
Defects in TPR are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of thethyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillarycarcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections offibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=Chromosomal aberrationsinvolving TPR are found in thyroid papillary carcinomas. Intrachromosomal rearrangement that links the 5'-end of theTPR gene to the protein kinase domain of NTRK1 forms the fusion protein TRK-T1. TRK-T1 is a 55 kDa protein reactingwith antibodies against the carboxy terminus of the NTRK1 protein Note=Involved in tumorigenic rearrangements with the MET or RAF genes
11  diseases for TPR: About MalaCardspediatric ependymoma ependymoma papillary thyroid carcinoma thyroid carcinoma
thyroiditis hepatitis b thyroid cancer carcinoma
prostate cancer hepatitis prostatitis
1 disease from the University of Copenhagen DISEASES database for TPR:Syphilis 2 Novoseek disease relationships for TPR gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| thyroid papillary carcinoma |
63.3 |
1 |
1532241 (1) |
| tumors |
0 |
1 |
19577736 (1) |
Human Genome Epidemiology (HuGE) Navigator: TPR (5 documents)
Tumor Gene Database (TGDB): TPR
Export disorders for TPR gene to outside databases
|
Publications
for TPR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TPR gene, integrated from 9 sources (see all 80):
(articles sorted by number of sources associating them with TPR) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. (PubMed id 15229283)1, 3, 9 Krull S....Cordes V.C. (2004)
- TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas. (PubMed id 1532241)1, 2, 9 Greco A....Della Porta G. (1992)
- Tpr directly binds to Mad1 and Mad2 and is important for the Mad1- Mad2-mediated mitotic spindle checkpoint. (PubMed id 18981471)1, 2 Lee S.H.... McCormick F. (2008)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex. (PubMed id 7798308)1, 2 Byrd D.A.... Gerace L. (1994)
- Localization of the 5' end of the MCF2 oncogene to hu man chromosome 15q15----q23. (PubMed id 1611909)1, 3 Galland F....Birnbaum D. (1992)
- The human tpr gene encodes a protein of 2094 amino acids that has extensive coiled-coil regions and an acidic C-terminal domain. (PubMed id 1437155)1, 2 Mitchell P.J. and Cooper C.S. (1992)
- tpr homologues activate met and raf. (PubMed id 3387099)1, 2 King H.W.S.... Rance A.J. (1988)
- Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. (PubMed id 18794356)1, 9 Vomastek T....Nandicoori V.K. (2008)
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External Searches for TPR gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing TPR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing TPR gene
(According to HUGE)
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Specialized Databases showing TPR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for TPR gene:
Search GeneIP for patents involving TPR
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TPR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TPR | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TPR | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TPR | | OriGene 3'-UTR Clone for TPR | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPR | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPR | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TPR | | OriGene Custom Protein Services for TPR | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TPR | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPR | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPR | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TPR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPR |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPR |
|  |  |  | | | | Search ThermoFisher Antibodies for TPR |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPR |
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