Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TPR Gene

Aliases for TPR Gene

  • Translocated Promoter Region, Nuclear Basket Protein 2 3 5
  • Translocated Promoter Region (To Activated MET Oncogene) 2 3
  • Translocated Promoter Region Protein 3 4
  • NPC-Associated Intranuclear Protein 3 4
  • Megator 3 4
  • Nuclear Pore Complex-Associated Protein TPR 3
  • Tumor Potentiating Region 3

External Ids for TPR Gene

Previous GeneCards Identifiers for TPR Gene

  • GC01M183808
  • GC01M181710
  • GC01M182802
  • GC01M183521
  • GC01M183014
  • GC01M184549
  • GC01M186281
  • GC01M157517
  • GC01M186282
  • GC01M186286
  • GC01M186312
  • GC01M186313

Summaries for TPR Gene

Entrez Gene Summary for TPR Gene

  • This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]

GeneCards Summary for TPR Gene

TPR (Translocated Promoter Region, Nuclear Basket Protein) is a Protein Coding gene. Diseases associated with TPR include differentiated thyroid carcinoma and bejel. Among its related pathways are Pathways in cancer and RNA transport. GO annotations related to this gene include poly(A) RNA binding and nucleotide binding.

UniProtKB/Swiss-Prot for TPR Gene

  • Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:22253824 and PubMed:11952838). Plays also a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPR Gene

Genomics for TPR Gene

Regulatory Elements for TPR Gene

Enhancers for TPR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TPR on UCSC Golden Path with GeneCards custom track

Promoters for TPR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TPR on UCSC Golden Path with GeneCards custom track

Genomic Location for TPR Gene

Chromosome:
1
Start:
186,311,652 bp from pter
End:
186,375,848 bp from pter
Size:
64,197 bases
Orientation:
Minus strand

Genomic View for TPR Gene

Genes around TPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPR Gene

Proteins for TPR Gene

  • Protein details for TPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12270-TPR_HUMAN
    Recommended name:
    Nucleoprotein TPR
    Protein Accession:
    P12270
    Secondary Accessions:
    • Q15624
    • Q15655
    • Q5SWY0
    • Q99968

    Protein attributes for TPR Gene

    Size:
    2363 amino acids
    Molecular mass:
    267293 Da
    Quaternary structure:
    • Interacts with IFI204 (via C-terminal region). Interacts with IFI203 (By similarity). Homodimer. Part of the nuclear pore complex (NPC). Associates with the XPO1/CRM1-mediated nuclear export complex, the Importin alpha/Importin beta receptor and the dynein 1 complex. Interacts (via C-terminal domain) with the KPNB1; the interaction occurs in a RanGTP-dependent manner. Interacts (via C-terminal regionand phosphorylated form) with MAPK1/ERK2 (via phosphorylated form); the interaction requires dimerization of MAPK1/ERK2 and increases following EGF stimulation. Interacts with MAPK3/ERK1; the interaction increases following EGF stimulation. Interacts (via coiled coil region) with NUP153; the interaction is direct. Interacts with HSF1; the interaction increases in a stress-responsive manner and stimulates export of stress-induced HSP70 mRNA. Interacts with huntingtin/HTT; the interaction is inhibited by aggregated huntingtin/HTT forms with expanded polyglutamine stretch. Interacts with MAD1L1 (via N-terminal region), MAD2L1, and TTK; the interactions occurs in a microtubule-independent manner. Interacts (via middle region) with DYNLL1. Interacts with DCTN1, dynein, NUP153 and tubulin. Interacts with MTA1.

    Alternative splice isoforms for TPR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPR Gene

Proteomics data for TPR Gene at MOPED

Post-translational modifications for TPR Gene

  • Phosphorylated. Phosphorylation occurs on serine and threonine residues (comprised in the C-terminal region) by MAPK1/ERK2 and stabilizes the interaction between these two proteins.
  • Proteolytically degraded after poliovirus (PV) infection; degradation is restricted to its unfolded C-terminal tail domain whereas its coiled-coil domain containing NCP- and NUP153-binding domains withstand degradation.
  • Ubiquitination at Lys 351, Lys 364, Lys 421, Lys 494, Lys 575, Lys 673, Lys 1038, Lys 1254, Lys 1296, Lys 1400, Lys 1491, Lys 1637, and Lys 1690
  • Modification sites at PhosphoSitePlus

Other Protein References for TPR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TPR Gene

Domains & Families for TPR Gene

Gene Families for TPR Gene

Protein Domains for TPR Gene

Suggested Antigen Peptide Sequences for TPR Gene

Graphical View of Domain Structure for InterPro Entry

P12270

UniProtKB/Swiss-Prot:

TPR_HUMAN :
  • The N-terminal domain mediates intranuclear attachment to the nuclear pore complex. The C-terminal domain mediates its nuclear import.
  • Belongs to the TPR family.
Domain:
  • The N-terminal domain mediates intranuclear attachment to the nuclear pore complex. The C-terminal domain mediates its nuclear import.
Family:
  • Belongs to the TPR family.
genes like me logo Genes that share domains with TPR: view

Function for TPR Gene

Molecular function for TPR Gene

GENATLAS Biochemistry:
translocated promoter region,involved in several rearrangements (TPR-MET;TPR-TRKA (NTRK1),with papillary thyroid carcinomas)
UniProtKB/Swiss-Prot Function:
Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:22253824 and PubMed:11952838). Plays also a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases.

Gene Ontology (GO) - Molecular Function for TPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 NOT transporter activity IMP 11952838
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0051019 mitogen-activated protein kinase binding IDA 18794356
genes like me logo Genes that share ontologies with TPR: view
genes like me logo Genes that share phenotypes with TPR: view

Human Phenotype Ontology for TPR Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TPR Gene

Localization for TPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPR Gene

Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus envelope. Nucleus, nuclear pore complex. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected as discrete intranuclear foci with IFI204 (By similarity). In interphase, localizes to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Detected exclusively to the cytoplasmic margin of NPC (PubMed:7798308). Docking to the inner nucleoplasmic side of the NPC is mediated through binding to nucleoporins. Anchored by NUP153 to the NPC. The assembly of the NPC is a stepwise process in which Trp-containing peripheral structures assemble after other components, including p62. Detected as filaments that emanate from the nuclear basket of the NPC and extend to the nucleolus to delineate a chromatin-free network extending from the nuclear envelope to the perinucleolar region. Detected in diffuse and discrete spheroidal intranuclear foci. Nucleocytoplasmic shuttling protein imported into the nucleus in a XPO1/CRM1- and Importin alpha/Importin beta receptor-dependent manner. Remains localized to the nuclear membrane after poliovirus (PV) infection. During mitosis, remains associated with the nuclear envelope until prometaphase. Associated with the mitotic spindle from late prometaphase until anaphase. Reorganized during mitosis in a viscous and dynamic nuclear-derived spindle matrix that embeds the microtubule spindle apparatus from pole to pole in a microtubule-independent manner. Recruited to the reforming nuclear envelope during telophase and cytokinesis. Detected at kinetochores during prometaphase (PubMed:18981471). Colocalizes with MAD2L1 in the spindle matrix but not at kinetochore (PubMed:19273613). Colocalizes with dynein, dynactin, tubulin at kinetochore during the metaphase-anaphase transition. Colocalizes with DYNLL1 at the mitotic spindle. {ECO:0000250, ECO:0000269 PubMed:18981471, ECO:0000269 PubMed:19273613, ECO:0000269 PubMed:7798308}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPR Gene COMPARTMENTS Subcellular localization image for TPR gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11952838
GO:0031965 nuclear membrane IDA 9024684
genes like me logo Genes that share ontologies with TPR: view

Pathways & Interactions for TPR Gene

SuperPathways for TPR Gene

Superpath Contained pathways
1 Regulation of Glucokinase by Glucokinase Regulatory Protein
2 Infectious disease
.48
3 Cell Cycle, Mitotic
.61
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with TPR: view

SIGNOR curated interactions for TPR Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000189 MAPK import into nucleus IMP 18794356
GO:0000278 mitotic cell cycle TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0006611 NOT protein export from nucleus IMP 11952838
genes like me logo Genes that share ontologies with TPR: view

Drugs & Compounds for TPR Gene

(6) Drugs for TPR Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma Target 0
Maleic acid Experimental Pharma Target 287
N-{(1s)-4-[Bis(2-Chloroethyl)Amino]-1-Methylbutyl}-N-(6-Chloro-2-Methoxy-9-Acridinyl)Amine Experimental Pharma Target 0
Trypanothione Experimental Pharma Target 0
genes like me logo Genes that share compounds with TPR: view

Transcripts for TPR Gene

Unigene Clusters for TPR Gene

Translocated promoter region, nuclear basket protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPR Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -
SP22:
SP23:

ExUns: 21a · 21b ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b · 24c ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b · 27c ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b ^ 31 ^ 32 ^ 33 ^ 34a ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

ExUns: 34b · 34c ^ 35 ^ 36a · 36b · 36c ^ 37 ^ 38a · 38b ^ 39a · 39b · 39c ^ 40a · 40b ^ 41a · 41b ^ 42a · 42b ^ 43a · 43b ^ 44a · 44b ^ 45a · 45b · 45c ^ 46 ^
SP1:
SP2:
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16: -
SP17:
SP18:
SP19: -
SP20:
SP21:
SP22:
SP23:

ExUns: 47 ^ 48 ^ 49 ^ 50 ^ 51 ^ 52 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

Relevant External Links for TPR Gene

GeneLoc Exon Structure for
TPR
ECgene alternative splicing isoforms for
TPR

Expression for TPR Gene

mRNA expression in normal human tissues for TPR Gene

Protein differential expression in normal tissues from HIPED for TPR Gene

This gene is overexpressed in Lymph node (9.6) and Peripheral blood mononuclear cells (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPR Gene



SOURCE GeneReport for Unigene cluster for TPR Gene Hs.279640

mRNA Expression by UniProt/SwissProt for TPR Gene

P12270-TPR_HUMAN
Tissue specificity: Expressed in esophagus, ovary, liver, skin, smooth muscles, cerebrum and fetal cerebellum (at protein level). Highest in testis, lung, thymus, spleen and brain, lower levels in heart, liver and kidney.
genes like me logo Genes that share expression patterns with TPR: view

Protein tissue co-expression partners for TPR Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TPR Gene

Orthologs for TPR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TPR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TPR 35
  • 92.55 (n)
  • 96.21 (a)
TPR 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPR 35
  • 92.99 (n)
  • 97.31 (a)
TPR 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tpr 35
  • 88.13 (n)
  • 93.73 (a)
Tpr 16
Tpr 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TPR 35
  • 99.65 (n)
  • 99.75 (a)
TPR 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tpr 35
  • 88.12 (n)
  • 94.04 (a)
oppossum
(Monodelphis domestica)
Mammalia TPR 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves TPR 35
  • 78.66 (n)
  • 84.05 (a)
TPR 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TPR 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tpr 35
  • 70.16 (n)
  • 71.32 (a)
African clawed frog
(Xenopus laevis)
Amphibia tpr 35
zebrafish
(Danio rerio)
Actinopterygii Dr.2655 35
tprb 35
  • 62.05 (n)
  • 60.77 (a)
tprb 36
  • 59 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10884 35
fruit fly
(Drosophila melanogaster)
Insecta Mtor 37
  • 23 (a)
Mtor 35
  • 41.13 (n)
  • 28.12 (a)
Mtor 36
  • 22 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001754 35
  • 41.53 (n)
  • 31.63 (a)
worm
(Caenorhabditis elegans)
Secernentea R07G3.3a 37
  • 20 (a)
R07G3.3b 37
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MLP1 36
  • 21 (a)
OneToMany
MLP2 36
  • 20 (a)
OneToMany
MLP1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToOne
Species with no ortholog for TPR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPR Gene

ENSEMBL:
Gene Tree for TPR (if available)
TreeFam:
Gene Tree for TPR (if available)

Paralogs for TPR Gene

(1) SIMAP similar genes for TPR Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TPR: view

No data available for Paralogs for TPR Gene

Variants for TPR Gene

Sequence variations from dbSNP and Humsavar for TPR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3753565 - 186,347,356(-) TACGA(A/G)CAATG reference, missense
rs35550453 - 186,338,112(+) TTTTG(A/C)CTTTT reference, missense
rs35766045 - 186,334,388(+) ATTTG(C/T)AACAG reference, missense
rs878041 -- 186,360,125(-) CTAGT(G/T)CTGTG intron-variant
rs857586 -- 186,317,229(-) TTCAT(C/T)TAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPR Gene

Variant ID Type Subtype PubMed ID
nsv523794 CNV Loss 19592680
esv2528820 CNV Deletion 19546169

Variation tolerance for TPR Gene

Residual Variation Intolerance Score: 1.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.27; 85.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPR Gene

HapMap Linkage Disequilibrium report
TPR
Human Gene Mutation Database (HGMD)
TPR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPR Gene

Disorders for TPR Gene

MalaCards: The human disease database

(11) MalaCards diseases for TPR Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
bejel
  • njovera
latent syphilis
  • syphilis, latent
yaws
  • bouba
prostate cancer 1
  • prostate cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search TPR in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TPR_HUMAN
  • Note=A chromosomal aberration involving TPR has been found in papillary thyroid carcinomas (PTCs). Intrachromosomal rearrangement that links the 5-end of the TPR gene to the protein kinase domain of NTRK1 forms the fusion protein TRK-T1. TRK-T1 is a 55 kDa protein reacting with antibodies against the carboxy terminus of the NTRK1 protein. {ECO:0000269 PubMed:1532241}.
  • Note=Involved in tumorigenic rearrangements with the MET. {ECO:0000269 PubMed:2300559}.

Relevant External Links for TPR

Human Genome Epidemiology (HuGE) Navigator
TPR
Tumor Gene Database (TGDB):
TPR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPR
genes like me logo Genes that share disorders with TPR: view

No data available for Genatlas for TPR Gene

Publications for TPR Gene

  1. Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. (PMID: 15229283) Krull S. … Cordes V.C. (Mol. Biol. Cell 2004) 2 3 4 23 67
  2. Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. (PMID: 18794356) Vomastek T. … Nandicoori V.K. (Mol. Cell. Biol. 2008) 3 23
  3. Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments. (PMID: 9024684) Cordes V.C. … Franke W.W. (J. Cell Biol. 1997) 3 23
  4. Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23. (PMID: 1611909) Galland F. … Birnbaum D. (Cytogenet. Cell Genet. 1992) 2 3
  5. TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas. (PMID: 1532241) Greco A. … Della Porta G. (Oncogene 1992) 3 23

Products for TPR Gene

Sources for TPR Gene

Content