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Aliases for TPPP3 Gene

Aliases for TPPP3 Gene

  • Tubulin Polymerization Promoting Protein Family Member 3 2 3 5
  • TPPP/P20 3 4
  • Tubulin Polymerization-Promoting Protein Family Member 3 3
  • Brain Specific Protein 3
  • P25gamma 3
  • CGI-38 3
  • P20 3

External Ids for TPPP3 Gene

Previous GeneCards Identifiers for TPPP3 Gene

  • GC16M065984
  • GC16M053296

Summaries for TPPP3 Gene

GeneCards Summary for TPPP3 Gene

TPPP3 (Tubulin Polymerization Promoting Protein Family Member 3) is a Protein Coding gene. Diseases associated with TPPP3 include Cerebrospinal Fluid Leak and Creutzfeldt-Jakob Disease. GO annotations related to this gene include tubulin binding. An important paralog of this gene is TPPP.

UniProtKB/Swiss-Prot for TPPP3 Gene

  • Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPPP3 Gene

Genomics for TPPP3 Gene

Regulatory Elements for TPPP3 Gene

Enhancers for TPPP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G067362 1.3 Ensembl ENCODE 11.7 +29.5 29464 3.0 FOXA2 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF48 ZNF121 GLIS2 ZNF143 LRRC36 RNU1-123P TPPP3 PLEKHG4 ZDHHC1 HSD11B2 PRMT7
GH16G067832 1.5 FANTOM5 ENCODE 5.8 -439.9 -439876 2.2 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 DUS2 PRMT7 DPEP2 TPPP3 CENPT PIR37129 TSNAXIP1
GH16G067346 0.7 ENCODE 11.7 +47.0 47023 0.2 JUN CEBPB EP300 RFX5 FOXA1 GATA3 GATA2 STAT3 CREB1 FOS RNU1-123P TPPP3 ZDHHC1 PLEKHG4 HSD11B2 MIR328 ELMO3 LRRC36
GH16G067854 1.7 FANTOM5 Ensembl ENCODE 3.7 -463.6 -463641 4.4 FOXA2 PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 FEZF1 YY1 RANBP10 ACD NRN1L TSNAXIP1 DUS2 PSKH1 PARD6A RIPOR1 PRMT7 SLC7A6
GH16G067860 1.4 FANTOM5 Ensembl ENCODE 4.3 -468.8 -468770 4.1 PKNOX1 THRB ZNF121 SCRT2 FOS CEBPB ZNF623 MAFF HMBOX1 ZBTB33 NRN1L THAP11 PSKH1 TSNAXIP1 RANBP10 RIPOR1 PRMT7 ACD PARD6A CARMIL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TPPP3 on UCSC Golden Path with GeneCards custom track

Promoters for TPPP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000087111 -65 401 SIN3A ARID4B RAD21 GLIS2 EGR1 ZNF143 KLF7 SP3 SP5 REST

Genomic Location for TPPP3 Gene

Chromosome:
16
Start:
67,389,807 bp from pter
End:
67,393,535 bp from pter
Size:
3,729 bases
Orientation:
Minus strand

Genomic View for TPPP3 Gene

Genes around TPPP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPPP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPPP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPPP3 Gene

Proteins for TPPP3 Gene

  • Protein details for TPPP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW30-TPPP3_HUMAN
    Recommended name:
    Tubulin polymerization-promoting protein family member 3
    Protein Accession:
    Q9BW30
    Secondary Accessions:
    • Q49AH9
    • Q9Y326
    • Q9Y6H0

    Protein attributes for TPPP3 Gene

    Size:
    176 amino acids
    Molecular mass:
    18985 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD44478.1; Type=Frameshift; Positions=52, 77, 83, 89; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TPPP3 Gene

neXtProt entry for TPPP3 Gene

Post-translational modifications for TPPP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TPPP3 Gene

No data available for DME Specific Peptides for TPPP3 Gene

Domains & Families for TPPP3 Gene

Gene Families for TPPP3 Gene

Protein Domains for TPPP3 Gene

Suggested Antigen Peptide Sequences for TPPP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BW30

UniProtKB/Swiss-Prot:

TPPP3_HUMAN :
  • Belongs to the TPPP family.
Family:
  • Belongs to the TPPP family.
genes like me logo Genes that share domains with TPPP3: view

Function for TPPP3 Gene

Molecular function for TPPP3 Gene

UniProtKB/Swiss-Prot Function:
Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis.

Gene Ontology (GO) - Molecular Function for TPPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015631 tubulin binding IDA 17105200
genes like me logo Genes that share ontologies with TPPP3: view
genes like me logo Genes that share phenotypes with TPPP3: view

Animal Model Products

CRISPR Products

miRNA for TPPP3 Gene

miRTarBase miRNAs that target TPPP3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPPP3 Gene

Localization for TPPP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPPP3 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPPP3 gene
Compartment Confidence
extracellular 5
cytoskeleton 4
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for TPPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TPPP3: view

Pathways & Interactions for TPPP3 Gene

SuperPathways for TPPP3 Gene

No Data Available

Interacting Proteins for TPPP3 Gene

Gene Ontology (GO) - Biological Process for TPPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation IDA 17105200
GO:0046785 microtubule polymerization IEA --
genes like me logo Genes that share ontologies with TPPP3: view

No data available for Pathways by source and SIGNOR curated interactions for TPPP3 Gene

Drugs & Compounds for TPPP3 Gene

(3) Drugs for TPPP3 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CHM 1 Pharma Tubulin polymerization inhibitor 0

(1) ApexBio Compounds for TPPP3 Gene

Compound Action Cas Number
CHM 1 Tubulin polymerization inhibitor 154554-41-3
genes like me logo Genes that share compounds with TPPP3: view

Drug Products

Transcripts for TPPP3 Gene

Unigene Clusters for TPPP3 Gene

Tubulin polymerization-promoting protein family member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPPP3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for TPPP3 Gene

GeneLoc Exon Structure for
TPPP3
ECgene alternative splicing isoforms for
TPPP3

Expression for TPPP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPPP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TPPP3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.3) and Brain - Hypothalamus (x4.2).

Protein differential expression in normal tissues from HIPED for TPPP3 Gene

This gene is overexpressed in Nasal epithelium (21.6), Oral epithelium (6.8), and Spinal cord (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TPPP3 Gene



Protein tissue co-expression partners for TPPP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of TPPP3 Gene:

TPPP3

SOURCE GeneReport for Unigene cluster for TPPP3 Gene:

Hs.534458

Evidence on tissue expression from TISSUES for TPPP3 Gene

  • Nervous system(4.9)
  • Eye(4.2)
  • Lung(2)
genes like me logo Genes that share expression patterns with TPPP3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPPP3 Gene

Orthologs for TPPP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPPP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TPPP3 34 35
  • 92.8 (n)
oppossum
(Monodelphis domestica)
Mammalia TPPP3 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPPP3 34 35
  • 90.91 (n)
rat
(Rattus norvegicus)
Mammalia Tppp3 34
  • 89.96 (n)
mouse
(Mus musculus)
Mammalia Tppp3 34 16 35
  • 89.77 (n)
chicken
(Gallus gallus)
Aves TPPP3 35
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TPPP3 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tppp3 34
  • 70.64 (n)
Str.17126 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.2908 34
zebrafish
(Danio rerio)
Actinopterygii tppp3 35
  • 71 (a)
OneToOne
LOC559490 34
  • 67.07 (n)
zgc77934 34
fruit fly
(Drosophila melanogaster)
Insecta CG4893 35
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C32E8.3 35
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToMany
Species where no ortholog for TPPP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPPP3 Gene

ENSEMBL:
Gene Tree for TPPP3 (if available)
TreeFam:
Gene Tree for TPPP3 (if available)

Paralogs for TPPP3 Gene

Paralogs for TPPP3 Gene

(3) SIMAP similar genes for TPPP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TPPP3: view

Variants for TPPP3 Gene

Sequence variations from dbSNP and Humsavar for TPPP3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000177730 -- 67,394,562(+) CATAG(A/G)GAGTC upstream-variant-2KB, utr-variant-3-prime
rs1000451871 -- 67,392,298(+) GTCCA(C/G)CACTA intron-variant
rs1000502765 -- 67,393,437(+) GGACC(G/T)ATGGA utr-variant-5-prime
rs1000503652 -- 67,391,914(+) GGCTT(C/T)CTGGC intron-variant
rs1000619018 -- 67,393,612(+) GCCCC(A/G)CCCAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TPPP3 Gene

Variant ID Type Subtype PubMed ID
nsv471092 CNV gain 18288195
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv952045 CNV deletion 24416366

Variation tolerance for TPPP3 Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPPP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TPPP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPPP3 Gene

Disorders for TPPP3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TPPP3 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
cerebrospinal fluid leak
  • csf leak
creutzfeldt-jakob disease
  • creutzfeldt-jakob disease, variant
- elite association - COSMIC cancer census association via MalaCards
Search TPPP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TPPP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPPP3
genes like me logo Genes that share disorders with TPPP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPPP3 Gene

Publications for TPPP3 Gene

  1. Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. (PMID: 17105200) Vincze O. … Ovadi J. (Biochemistry 2006) 2 3 4 22 64
  2. Depletion of tubulin polymerization promoting protein family member 3 suppresses HeLa cell proliferation. (PMID: 19633818) Zhou W. … Hu R. (Mol. Cell. Biochem. 2010) 3 4 64
  3. p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. (PMID: 15590652) Lindersson E. … Jensen P.H. (J. Biol. Chem. 2005) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4 64

Products for TPPP3 Gene

Sources for TPPP3 Gene

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