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Aliases for TPPP3 Gene

Aliases for TPPP3 Gene

  • Tubulin Polymerization-Promoting Protein Family Member 3 2 3
  • TPPP/P20 3 4
  • Brain Specific Protein 3
  • P25gamma 3
  • CGI-38 3
  • P20 3

External Ids for TPPP3 Gene

Summaries for TPPP3 Gene

GeneCards Summary for TPPP3 Gene

TPPP3 (Tubulin Polymerization-Promoting Protein Family Member 3) is a Protein Coding gene. Diseases associated with TPPP3 include cerebrospinal fluid leak and schizophrenia. GO annotations related to this gene include tubulin binding. An important paralog of this gene is TPPP.

UniProtKB/Swiss-Prot for TPPP3 Gene

  • Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPPP3 Gene

Genomics for TPPP3 Gene

Genomic Location for TPPP3 Gene

Start:
67,389,807 bp from pter
End:
67,393,546 bp from pter
Size:
3,740 bases
Orientation:
Minus strand

Genomic View for TPPP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPPP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPPP3 Gene

Regulatory Elements for TPPP3 Gene

Proteins for TPPP3 Gene

  • Protein details for TPPP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW30-TPPP3_HUMAN
    Recommended name:
    Tubulin polymerization-promoting protein family member 3
    Protein Accession:
    Q9BW30
    Secondary Accessions:
    • Q49AH9
    • Q9Y326
    • Q9Y6H0

    Protein attributes for TPPP3 Gene

    Size:
    176 amino acids
    Molecular mass:
    18985 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD44478.1; Type=Frameshift; Positions=52, 77, 83, 89; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TPPP3 Gene

neXtProt entry for TPPP3 Gene

Proteomics data for TPPP3 Gene at MOPED

Post-translational modifications for TPPP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TPPP3 Gene

No data available for DME Specific Peptides for TPPP3 Gene

Domains for TPPP3 Gene

Protein Domains for TPPP3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TPPP3_HUMAN
Family:
  • Belongs to the TPPP family.:
    • Q9BW30
genes like me logo Genes that share domains with TPPP3: view

No data available for Gene Families for TPPP3 Gene

Function for TPPP3 Gene

Molecular function for TPPP3 Gene

UniProtKB/Swiss-Prot Function: Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis.

Gene Ontology (GO) - Molecular Function for TPPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015631 tubulin binding IDA 17105200
genes like me logo Genes that share ontologies with TPPP3: view

Phenotypes for TPPP3 Gene

GenomeRNAi human phenotypes for TPPP3:
genes like me logo Genes that share phenotypes with TPPP3: view

miRNA for TPPP3 Gene

miRTarBase miRNAs that target TPPP3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TPPP3 Gene

Localization for TPPP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPPP3 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPPP3 Gene COMPARTMENTS Subcellular localization image for TPPP3 gene
Compartment Confidence
cytoskeleton 4
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TPPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TPPP3: view

Pathways for TPPP3 Gene

SuperPathways for TPPP3 Gene

No Data Available

Interacting Proteins for TPPP3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000290942%0d%0a9606.ENSP00000250416%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000326042%0d%0a9606.ENSP00000333326%0d%0a9606.ENSP00000357651%0d%0a
Selected Interacting proteins: ENSP00000290942 Q9BW30-TPPP3_HUMAN for TPPP3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TPPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation IDA 17105200
genes like me logo Genes that share ontologies with TPPP3: view

No data available for Pathways by source for TPPP3 Gene

Compounds for TPPP3 Gene

(2) Novoseek inferred chemical compound relationships for TPPP3 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 0 2
dopamine 0 1
genes like me logo Genes that share compounds with TPPP3: view

Transcripts for TPPP3 Gene

Unigene Clusters for TPPP3 Gene

Tubulin polymerization-promoting protein family member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPPP3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for TPPP3 Gene

GeneLoc Exon Structure for
TPPP3
ECgene alternative splicing isoforms for
TPPP3

Expression for TPPP3 Gene

mRNA expression in normal human tissues for TPPP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TPPP3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.3) and Brain - Hypothalamus (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPPP3 Gene

SOURCE GeneReport for Unigene cluster for TPPP3 Gene Hs.534458

genes like me logo Genes that share expressions with TPPP3: view

Orthologs for TPPP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPPP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TPPP3 36
  • 92.8 (n)
  • 96.02 (a)
TPPP3 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPPP3 36
  • 90.91 (n)
  • 96.02 (a)
TPPP3 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tppp3 36
  • 89.77 (n)
  • 96.59 (a)
Tppp3 16
Tppp3 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TPPP3 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tppp3 36
  • 89.96 (n)
  • 96.02 (a)
chicken
(Gallus gallus)
Aves TPPP3 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TPPP3 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2908 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17126 36
tppp3 36
  • 70.64 (n)
  • 78.41 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC559490 36
  • 67.07 (n)
  • 71.86 (a)
tppp3 37
  • 71 (a)
OneToOne
zgc77934 36
fruit fly
(Drosophila melanogaster)
Insecta CG4893 37
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C32E8.3 37
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 44 (a)
OneToMany
Species with no ortholog for TPPP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPPP3 Gene

ENSEMBL:
Gene Tree for TPPP3 (if available)
TreeFam:
Gene Tree for TPPP3 (if available)

Paralogs for TPPP3 Gene

Paralogs for TPPP3 Gene

Selected SIMAP similar genes for TPPP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TPPP3: view

Variants for TPPP3 Gene

Sequence variations from dbSNP and Humsavar for TPPP3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs897901 -- 67,391,295(-) TTCCT(C/T)GGGGC intron-variant
rs1053612 -- 67,390,036(-) CCCAC(C/T)GGGCT utr-variant-3-prime
rs1423745 -- 67,391,876(+) GGGCA(C/T)GCCAG intron-variant
rs3785095 -- 67,392,966(-) CTGGA(C/T)GTTAC intron-variant, utr-variant-5-prime, reference, missense
rs8053264 -- 67,390,790(+) AGATA(C/T)AAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPPP3 Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680
nsv471092 CNV Gain 18288195
nsv906806 CNV Loss 21882294

Relevant External Links for TPPP3 Gene

HapMap Linkage Disequilibrium report
TPPP3

Disorders for TPPP3 Gene

(12) Novoseek inferred disease relationships for TPPP3 Gene

Disease -log(P) Hits PubMed IDs
creutzfeldt-jakob disease 51.2 1
neurodegenerative diseases 42.1 2
neurological disorders 41.1 1
huntington disease 36.3 1
dementia 34 2
genes like me logo Genes that share disorders with TPPP3: view

No data available for UniProtKB/Swiss-Prot for TPPP3 Gene

Publications for TPPP3 Gene

  1. Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. (PMID: 17105200) Vincze O. … Ovadi J. (Biochemistry 2006) 2 3 4 23
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4
  3. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. (PMID: 15590652) Lindersson E. … Jensen P.H. (J. Biol. Chem. 2005) 2 3

Products for TPPP3 Gene

Sources for TPPP3 Gene

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