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Aliases for TPPP3 Gene

Aliases for TPPP3 Gene

  • Tubulin Polymerization Promoting Protein Family Member 3 2 3 5
  • TPPP/P20 3 4
  • Tubulin Polymerization-Promoting Protein Family Member 3 3
  • Brain Specific Protein 3
  • P25gamma 3
  • CGI-38 3
  • P20 3

External Ids for TPPP3 Gene

Previous GeneCards Identifiers for TPPP3 Gene

  • GC16M065984
  • GC16M053296

Summaries for TPPP3 Gene

GeneCards Summary for TPPP3 Gene

TPPP3 (Tubulin Polymerization Promoting Protein Family Member 3) is a Protein Coding gene. Diseases associated with TPPP3 include Cerebrospinal Fluid Leak and Creutzfeldt-Jakob Disease. GO annotations related to this gene include tubulin binding. An important paralog of this gene is TPPP.

UniProtKB/Swiss-Prot for TPPP3 Gene

  • Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPPP3 Gene

Genomics for TPPP3 Gene

Regulatory Elements for TPPP3 Gene

Enhancers for TPPP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F067362 1.3 Ensembl ENCODE 11.7 +29.3 29260 3.4 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF48 ZNF121 KLF7 SP3 REST LRRC36 RNU1-123P TPPP3 PLEKHG4 ZDHHC1 HSD11B2 PRMT7
GH16F067832 1.5 FANTOM5 ENCODE 5.8 -439.9 -439876 2.2 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 PSKH1 ZDHHC1 DUS2 B3GNT9 PRMT7 DPEP2 TPPP3 CENPT PIR37129 TSNAXIP1
GH16F067346 0.6 ENCODE 11.6 +47.0 47023 0.2 GATA3 JUN CEBPB STAT3 EP300 RFX5 RNU1-123P TPPP3 ZDHHC1 PLEKHG4 HSD11B2 MIR328 ELMO3 LRRC36
GH16F067854 1.8 FANTOM5 Ensembl ENCODE 3.8 -463.7 -463741 4.6 PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 RANBP10 ACD NRN1L TSNAXIP1 DUS2 PSKH1 E2F4 PARD6A FAM65A PRMT7
GH16F067860 1.4 FANTOM5 Ensembl ENCODE 4.3 -468.8 -468770 4.1 SOX13 KLF1 PKNOX1 ZNF384 THRB ZNF121 ZNF664 ZNF316 GATA3 CTBP1 NRN1L THAP11 PSKH1 RANBP10 TSNAXIP1 FAM65A PRMT7 ACD PARD6A CARMIL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TPPP3 on UCSC Golden Path with GeneCards custom track

Promoters for TPPP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001802301 35 601 PKNOX1 SIN3A KLF17 ARID4B RAD21 GLIS2 ZNF143 KLF7 SP3 SP5
ENSR00000508963 -1165 201 CTCF ESRRA SUZ12 THRB ZSCAN9 RAD21 TEAD3 ZNF335 PATZ1 ZNF143

Genomic Location for TPPP3 Gene

Chromosome:
16
Start:
67,389,807 bp from pter
End:
67,393,535 bp from pter
Size:
3,729 bases
Orientation:
Minus strand

Genomic View for TPPP3 Gene

Genes around TPPP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPPP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPPP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPPP3 Gene

Proteins for TPPP3 Gene

  • Protein details for TPPP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW30-TPPP3_HUMAN
    Recommended name:
    Tubulin polymerization-promoting protein family member 3
    Protein Accession:
    Q9BW30
    Secondary Accessions:
    • Q49AH9
    • Q9Y326
    • Q9Y6H0

    Protein attributes for TPPP3 Gene

    Size:
    176 amino acids
    Molecular mass:
    18985 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD44478.1; Type=Frameshift; Positions=52, 77, 83, 89; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TPPP3 Gene

neXtProt entry for TPPP3 Gene

Post-translational modifications for TPPP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TPPP3 Gene

No data available for DME Specific Peptides for TPPP3 Gene

Domains & Families for TPPP3 Gene

Gene Families for TPPP3 Gene

Protein Domains for TPPP3 Gene

Suggested Antigen Peptide Sequences for TPPP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BW30

UniProtKB/Swiss-Prot:

TPPP3_HUMAN :
  • Belongs to the TPPP family.
Family:
  • Belongs to the TPPP family.
genes like me logo Genes that share domains with TPPP3: view

Function for TPPP3 Gene

Molecular function for TPPP3 Gene

UniProtKB/Swiss-Prot Function:
Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis.

Gene Ontology (GO) - Molecular Function for TPPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015631 tubulin binding IDA 17105200
genes like me logo Genes that share ontologies with TPPP3: view
genes like me logo Genes that share phenotypes with TPPP3: view

Animal Model Products

miRNA for TPPP3 Gene

miRTarBase miRNAs that target TPPP3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPPP3 Gene

Localization for TPPP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPPP3 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPPP3 gene
Compartment Confidence
extracellular 5
cytoskeleton 4
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for TPPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TPPP3: view

Pathways & Interactions for TPPP3 Gene

SuperPathways for TPPP3 Gene

No Data Available

Interacting Proteins for TPPP3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000290942%0d%0a9606.ENSP00000250416%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000333326%0d%0a9606.ENSP00000326042%0d%0a9606.ENSP00000341289%0d%0a
Selected Interacting proteins: Q9BW30-TPPP3_HUMAN ENSP00000290942 for TPPP3 Gene via IID STRING

Gene Ontology (GO) - Biological Process for TPPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation IDA 17105200
GO:0046785 microtubule polymerization IEA --
genes like me logo Genes that share ontologies with TPPP3: view

No data available for Pathways by source and SIGNOR curated interactions for TPPP3 Gene

Drugs & Compounds for TPPP3 Gene

(3) Drugs for TPPP3 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CHM 1 Pharma Tubulin polymerization inhibitor 0

(1) ApexBio Compounds for TPPP3 Gene

Compound Action Cas Number
CHM 1 Tubulin polymerization inhibitor 154554-41-3
genes like me logo Genes that share compounds with TPPP3: view

Transcripts for TPPP3 Gene

Unigene Clusters for TPPP3 Gene

Tubulin polymerization-promoting protein family member 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPPP3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for TPPP3 Gene

GeneLoc Exon Structure for
TPPP3
ECgene alternative splicing isoforms for
TPPP3

Expression for TPPP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TPPP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TPPP3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.3) and Brain - Hypothalamus (x4.2).

Protein differential expression in normal tissues from HIPED for TPPP3 Gene

This gene is overexpressed in Nasal epithelium (21.6), Oral epithelium (6.8), and Spinal cord (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TPPP3 Gene



Protein tissue co-expression partners for TPPP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of TPPP3 Gene:

TPPP3

SOURCE GeneReport for Unigene cluster for TPPP3 Gene:

Hs.534458
genes like me logo Genes that share expression patterns with TPPP3: view

No data available for mRNA Expression by UniProt/SwissProt for TPPP3 Gene

Orthologs for TPPP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPPP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TPPP3 34 35
  • 92.8 (n)
oppossum
(Monodelphis domestica)
Mammalia TPPP3 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPPP3 34 35
  • 90.91 (n)
rat
(Rattus norvegicus)
Mammalia Tppp3 34
  • 89.96 (n)
mouse
(Mus musculus)
Mammalia Tppp3 34 16 35
  • 89.77 (n)
chicken
(Gallus gallus)
Aves TPPP3 35
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TPPP3 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tppp3 34
  • 70.64 (n)
Str.17126 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.2908 34
zebrafish
(Danio rerio)
Actinopterygii tppp3 35
  • 71 (a)
OneToOne
LOC559490 34
  • 67.07 (n)
zgc77934 34
fruit fly
(Drosophila melanogaster)
Insecta CG4893 35
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C32E8.3 35
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToMany
Species where no ortholog for TPPP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPPP3 Gene

ENSEMBL:
Gene Tree for TPPP3 (if available)
TreeFam:
Gene Tree for TPPP3 (if available)

Paralogs for TPPP3 Gene

Paralogs for TPPP3 Gene

(3) SIMAP similar genes for TPPP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TPPP3: view

Variants for TPPP3 Gene

Sequence variations from dbSNP and Humsavar for TPPP3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1053612 -- 67,390,036(-) CCCAC(C/T)GGGCT utr-variant-3-prime
rs11075657 -- 67,391,984(+) TGGGG(C/G)CTAGT intron-variant
rs112067596 -- 67,392,158(+) CCTGC(C/T)ACCCC intron-variant
rs112131378 -- 67,390,363(+) GCTTT(A/C)TGTTT splice-acceptor-variant
rs114529082 -- 67,393,652(+) GAGCC(A/G)CATCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TPPP3 Gene

Variant ID Type Subtype PubMed ID
nsv471092 CNV gain 18288195
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv952045 CNV deletion 24416366

Variation tolerance for TPPP3 Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPPP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TPPP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPPP3 Gene

Disorders for TPPP3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TPPP3 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
cerebrospinal fluid leak
  • csf leak
creutzfeldt-jakob disease
  • creutzfeldt-jakob disease, variant
- elite association - COSMIC cancer census association via MalaCards
Search TPPP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TPPP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPPP3
genes like me logo Genes that share disorders with TPPP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPPP3 Gene

Publications for TPPP3 Gene

  1. Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. (PMID: 17105200) Vincze O. … Ovadi J. (Biochemistry 2006) 2 3 4 22 64
  2. Depletion of tubulin polymerization promoting protein family member 3 suppresses HeLa cell proliferation. (PMID: 19633818) Zhou W. … Hu R. (Mol. Cell. Biochem. 2010) 3 4 64
  3. p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. (PMID: 15590652) Lindersson E. … Jensen P.H. (J. Biol. Chem. 2005) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4 64

Products for TPPP3 Gene

Sources for TPPP3 Gene

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