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TPPP2 Gene(Protein Coding)

Tubulin Polymerization Promoting Protein Family Member 2

GCID:
GC14P021043
GIFtS:
44
Genes Participants
UDN Logo

Aliases for TPPP2 Gene

Aliases for TPPP2 Gene

  • Tubulin Polymerization Promoting Protein Family Member 2 2 3
  • Protein P25-Beta 3 4
  • TPPP/P18 3 4
  • C14orf8 3 4
  • Tubulin Polymerization-Promoting Protein Family Member 2 5
  • Chromosome 14 Open Reading Frame 8 2
  • P25beta 3
  • CT152 3
  • P18 3

External Ids for TPPP2 Gene

Previous HGNC Symbols for TPPP2 Gene

  • C14orf8

Previous GeneCards Identifiers for TPPP2 Gene

  • GC14P020569
  • GC14P021498
  • GC14P001619
  • GC14P021031
  • GC14P021033

Summaries for TPPP2 Gene

GeneCards Summary for TPPP2 Gene

TPPP2 (Tubulin Polymerization Promoting Protein Family Member 2) is a Protein Coding gene. An important paralog of this gene is TPPP3.

UniProtKB/Swiss-Prot for TPPP2 Gene

  • May bind tubulin but has no microtubule bundling activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPPP2 Gene

Genomics for TPPP2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for TPPP2 Gene

Enhancers for TPPP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TPPP2 on UCSC Golden Path with GeneCards custom track

Promoters for TPPP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TPPP2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TPPP2 gene promoter:

Genomic Location for TPPP2 Gene

Chromosome:
14
Start:
21,024,109 bp from pter
End:
21,036,352 bp from pter
Size:
12,244 bases
Orientation:
Plus strand

Genomic View for TPPP2 Gene

Genes around TPPP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPPP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPPP2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TPPP2 Gene

Proteins for TPPP2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TPPP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59282-TPPP2_HUMAN
    Recommended name:
    Tubulin polymerization-promoting protein family member 2
    Protein Accession:
    P59282
    Secondary Accessions:
    • Q2VYF3

    Protein attributes for TPPP2 Gene

    Size:
    170 amino acids
    Molecular mass:
    18503 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TPPP2 Gene

Proteomics data for TPPP2 Gene at MOPED

Protein Expression for TPPP2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TPPP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TPPP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TPPP2 Gene

Domains & Families for TPPP2 Gene

Gene Families for TPPP2 Gene

HGNC:

Protein Domains for TPPP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TPPP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59282

UniProtKB/Swiss-Prot:

TPPP2_HUMAN :
  • Belongs to the TPPP family.
Family:
  • Belongs to the TPPP family.
genes like me logo Genes that share domains with TPPP2: view

Function for TPPP2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for TPPP2 Gene

UniProtKB/Swiss-Prot Function:
May bind tubulin but has no microtubule bundling activity.

Phenotypes for TPPP2 Gene

GenomeRNAi human phenotypes for TPPP2:
genes like me logo Genes that share phenotypes with TPPP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TPPP2 Gene

Localization for TPPP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPPP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPPP2 Gene COMPARTMENTS Subcellular localization image for TPPP2 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for TPPP2 Gene

Pathways & Interactions for TPPP2 Gene

SuperPathways for TPPP2 Gene

PathCards logoMore details on SuperPathways for TPPP2
No Data Available

Interacting Proteins for TPPP2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000317595%0d%0a9606.ENSP00000333326%0d%0a9606.ENSP00000264071%0d%0a9606.ENSP00000451560%0d%0a9606.ENSP00000320295%0d%0a9606.ENSP00000341289%0d%0a
Selected Interacting proteins: ENSP00000317595 for TPPP2 Gene via STRING

Gene Ontology (GO) - Biological Process for TPPP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TPPP2 Gene

Drugs & Compounds for TPPP2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for TPPP2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for TPPP2 Gene

(7) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(44) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TPPP2 Gene

Tubulin polymerization-promoting protein family member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPPP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5: - - - -

Relevant External Links for TPPP2 Gene

GeneLoc Exon Structure for
TPPP2
ECgene alternative splicing isoforms for
TPPP2

Expression for TPPP2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for TPPP2 Gene

mRNA expression in normal human tissues for TPPP2 Gene
mRNA expression by BioGPS for TPPP2 GenemRNA expression by GTEx for TPPP2 Gene

mRNA differential expression in normal tissues according to GTEx for TPPP2 Gene

This gene is overexpressed in Testis (x48.5).

Protein differential expression in normal tissues from HIPED for TPPP2 Gene

This gene is overexpressed in Testis (28.5), Skin (15.1), Ovary (14.4), and Heart (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TPPP2 Gene



SOURCE GeneReport for Unigene cluster for TPPP2 Gene Hs.406966

mRNA Expression by UniProt/SwissProt for TPPP2 Gene

P59282-TPPP2_HUMAN
Tissue specificity: Expressed in spermatids. Detected in liver cancer (at protein level).
genes like me logo Genes that share expression patterns with TPPP2: view

Protein tissue co-expression partners for TPPP2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TPPP2 Gene

Orthologs for TPPP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPPP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia TPPP2 35
  • 89.29 (n)
  • 91.67 (a)
TPPP2 36
  • 90 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia TPPP2 35
  • 86.31 (n)
  • 89.29 (a)
TPPP2 36
  • 85 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Tppp2 35
  • 83.14 (n)
  • 84.12 (a)
Tppp2 16
Tppp2 36
  • 84 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia TPPP2 35
  • 99.41 (n)
  • 100 (a)
TPPP2 36
  • 97 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Tppp2 35
  • 84.71 (n)
  • 87.65 (a)
oppossum
(Monodelphis domestica)
 Mammalia TPPP2 36
  • 71 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves TPPP2 35
  • 69.7 (n)
  • 65.45 (a)
TPPP2 36
  • 53 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia TPPP2 36
  • 66 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii TPPP2 36
  • 57 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG4893 36
  • 33 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea C32E8.3 35
  • 51.23 (n)
  • 43.21 (a)
C32E8.3 36
  • 38 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 39 (a)
 OneToMany
Species with no ortholog for TPPP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TPPP2 Gene

ENSEMBL:
Gene Tree for TPPP2 (if available)
TreeFam:
Gene Tree for TPPP2 (if available)

Paralogs for TPPP2 Gene

Paralogs for TPPP2 Gene

(3) SIMAP similar genes for TPPP2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TPPP2: view

Variants for TPPP2 Gene

Sequence variations from dbSNP and Humsavar for TPPP2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_059147 -

Structural Variations from Database of Genomic Variants (DGV) for TPPP2 Gene

Variant ID Type Subtype PubMed ID
nsv428293 CNV Gain+Loss 18775914
nsv832740 CNV Gain 17160897

Variation tolerance for TPPP2 Gene

Residual Variation Intolerance Score: 88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.49; 82.16% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TPPP2 Gene

Disorders for TPPP2 Gene

Relevant External Links for TPPP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPPP2

No disorders were found for TPPP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPPP2 Gene

Publications for TPPP2 Gene

  1. Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. (PMID: 17105200) Vincze O. … Ovadi J. (Biochemistry 2006) 2 3 4 67
  2. p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. (PMID: 15590652) Lindersson E. … Jensen P.H. (J. Biol. Chem. 2005) 2 3
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for TPPP2 Gene

Sources for TPPP2 Gene

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