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TPPP2 Gene

protein-coding   GIFtS: 43
GCID: GC14P021498

Tubulin Polymerization-Promoting Protein Family Member 2

(Previous name: chromosome 14 open reading frame 8)
(Previous symbol: C14orf8)
  Search for TPPP2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tubulin Polymerization-Promoting Protein Family Member 21 2     Chromosome 14 Open Reading Frame 81
C14orf81 2 3     CT1522
Protein P25-Beta2 3     P182
TPPP/p182 3     p25beta2

External Ids:    HGNC: 192931   Entrez Gene: 1226642   Ensembl: ENSG000001796367   UniProtKB: P592823   

Export aliases for TPPP2 gene to outside databases

Previous GC identifers: GC14P020569 GC14P001619


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TPPP2 Gene:
TPPP2 (tubulin polymerization-promoting protein family member 2) is a protein-coding gene. An important paralog of this gene is TPPP.

UniProtKB/Swiss-Prot: TPPP2_HUMAN, P59282
Function: May bind tubulin but has no microtubule bundling activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TPPP2 gene promoter:
         RP58   Nkx2-5   CREB   PPAR-gamma1   c-Rel   deltaCREB   ARP-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTPPP2 promoter sequence
   Search Chromatin IP Primers for TPPP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPPP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

TPPP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPPP2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021498:  view genomic region     (about GC identifiers)

Start:
21,492,268 bp from pter      End:
21,504,435 bp from pter
Size:
12,168 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TPPP2_HUMAN, P59282 (See protein sequence)
Recommended Name: Tubulin polymerization-promoting protein family member 2  
Size: 170 amino acids; 18503 Da
Secondary accessions: Q2VYF3

Explore the universe of human proteins at neXtProt for TPPP2: NX_P59282

Explore proteomics data for TPPP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TPPP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_776245.2  
    ENSEMBL proteins: 
     ENSP00000317595   ENSP00000427504   ENSP00000435356   ENSP00000423171   ENSP00000421438  
     ENSP00000436874   ENSP00000451899  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008907 P25-alpha

    Graphical View of Domain Structure for InterPro Entry P59282

    ProtoNet protein and cluster: P59282

    1 Blocks protein domain: IPB008907 P25-alpha

    UniProtKB/Swiss-Prot: TPPP2_HUMAN, P59282
    Similarity: Belongs to the TPPP family


    Find genes that share domains with TPPP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TPPP2_HUMAN, P59282
    Function: May bind tubulin but has no microtubule bundling activity

    Phenotypes:
         1 GenomeRNAi human phenotype for TPPP2:

     Decreased viability with pacli 

    Animal Models:
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    GenScript: all cDNA clones in your preferred vector: TPPP2 (NM_173846)
    Sino Biological Human cDNA Clone for TPPP2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPPP2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TPPP2_HUMAN, P59282: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with TPPP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TPPP2
    Interactions:

        Search GeneGlobe Interaction Network for TPPP2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TPPP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TPPP2 gene: 
    NM_173846.4  

    Unigene Cluster for TPPP2:

    Tubulin polymerization-promoting protein family member 2
    Hs.406966  [show with all ESTs]
    Unigene Representative Sequence: AK093070
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533755 ENST00000534434(uc001vzh.3) ENST00000525425 ENST00000321760
    ENST00000532060 ENST00000460647 ENST00000530140 ENST00000472458 ENST00000481535
    ENST00000529496 ENST00000495665 ENST00000555751
    miRNA
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    GenScript: all cDNA clones in your preferred vector: TPPP2 (NM_173846)
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      QuantiTect SYBR Green Assays in human, mouse, rat TPPP2
      QuantiFast Probe-based Assays in human, mouse, rat TPPP2

    Additional mRNA sequence: 

    AK093070.1 AK098680.1 AY072034.1 AY173946.1 BC027610.1 BC038970.2 BC064583.1 

    8 DOTS entries:

    DT.308753  DT.102821889  DT.100714385  DT.116983  DT.120755924  DT.120755926  DT.86852168  DT.70103724 

    Selected AceView cDNA sequences (see all 44):

    AI990760 AW135537 AI915840 BX492694 BC027610 AA812901 AI806847 AA861291 
    AA913948 BI460527 BE501240 BI827944 NM_173846 BM554263 BV190339 AI219847 
    AK098680 AI633873 AA448281 BC064583 AI187284 BG724262 BI463289 AA431560 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TPPP2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5
    SP1:                    -                       -                           
    SP2:                                            -                           
    SP3:                    -                       -                           
    SP4:                    -                                                   
    SP5:                                            -     -     -     -         


    ECgene alternative splicing isoforms for TPPP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TPPP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTAACACCA
    TPPP2 Expression
    About this image

    TPPP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TPPP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406966

    UniProtKB/Swiss-Prot: TPPP2_HUMAN, P59282
    Tissue specificity: Expressed in spermatids. Detected in liver cancer (at protein level)

        Custom PCR Arrays for TPPP2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPPP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TPPP2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tppp21 , 5 tubulin polymerization-promoting protein family member more1, 5 83.14(n)1
    84.12(a)1
      14 (26.72 cM)5
    2190381  NM_001128634.11  NP_001122106.11 
     519187615 
    chicken
    (Gallus gallus)
    Aves TPPP21 tubulin polymerization-promoting protein family member more 69.7(n)
    65.45(a)
      427270  XM_424853.3  XP_424853.1 
    lizard
    (Anolis carolinensis)
    Reptilia TPPP26
    tubulin polymerization-promoting protein family me...
    66(a)
    1 ↔ 1
    GL343253.1(1695209-1700295)
    zebrafish
    (Danio rerio)
    Actinopterygii TPPP26
    tubulin polymerization-promoting protein family me...
    57(a)
    1 ↔ 1
    5(38661354-38665606) ENSDARG00000035338
    fruit fly
    (Drosophila melanogaster)
    Insecta CG48936
    --
    33(a)
    1 → many
    3L(16347846-16352528)
    worm
    (Caenorhabditis elegans)
    Secernentea C32E8.31 C32E8.3 51.23(n)
    43.21(a)
      171948  NM_058818.3  NP_491219.1 


    ENSEMBL Gene Tree for TPPP2 (if available)
    TreeFam Gene Tree for TPPP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TPPP2 gene
    TPPP2  TPPP32  
    3 SIMAP similar genes for TPPP2 using alignment to 6 protein entries:     TPPP2_HUMAN (see all proteins):
    TPPP3    FREP1    TPPP

    Find genes that share paralogs with TPPP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TPPP2 (see all 135)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs720632811,2
    C--21496401(+) TTCTT-/TTTTG 
            
    TTTGT
    1 -- us2k10--------
    rs711125411,2
    C--21496404(+) GTTTTGTTTT/
            
    TGAGA
    1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs735838941,2
    C,F--21496441(+) GGGGTC/GTCTCT 1 -- us2k13Minor allele frequency- G:0.04WA CSA 122
    rs559705311,2
    C,F--21496653(+) TAGGCA/GTGAGC 1 -- us2k14Minor allele frequency- G:0.08WA NA 242
    rs1864779471,2
    --21496792(+) ATATCC/TTGAGC 1 -- us2k10--------
    rs12434561,2
    C,F,H--21496800(+) AGCCAT/CAGAAT 1 -- us2k113Minor allele frequency- C:0.29NA WA CSA EA 376
    rs800096281,2
    F--21497105(+) GATCCG/ATGAGG 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs1504390561,2
    --21497126(+) TGTAGA/TGCTTC 1 -- us2k10--------
    rs1380229511,2
    C--21497185(+) CCTGCA/GTAGAA 1 -- us2k10--------
    rs1495226281,2
    --21497219(+) CTGAGA/CCTCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TPPP2 (21492268 - 21504435 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TPPP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832740CNV Gain17160897
    nsv428293CNV Gain+Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TPPP2
    DNA2.0 Custom Variant and Variant Library Synthesis for TPPP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TPPP2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TPPP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. (PubMed id 17105200)1, 2, 3 Vincze O....Ovadi J. (Biochemistry 2006)
    2. p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. (PubMed id 15590652)1, 3 Lindersson E.... Jensen P.H. (J. Biol. Chem. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Scanning of novel cancer/testis proteins by human testis proteomic analysis. (PubMed id 23436708)2 Liu M....Sha J. (Proteomics 2013)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    6. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (Nature 2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 122664 HGNC: 19293 AceView: C14orf8 Ensembl:ENSG00000179636 euGenes: HUgn122664
    ECgene: TPPP2 H-InvDB: TPPP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TPPP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TPPP2 gene:
    Search GeneIP for patents involving TPPP2

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TPPP2  
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     Block miRNA regulation of human, mouse, rat TPPP2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TPPP2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPPP2 Predesigned siRNA for gene silencing in human, mouse, rat TPPP2
     QuantiFast Probe-based Assays in human, mouse, rat TPPP2 QuantiTect SYBR Green Assays in human, mouse, rat TPPP2
     Custom PCR Arrays for TPPP2 Search Chromatin IP Primers for TPPP2
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     Novus Tissue Slides
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TPPP2
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