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Aliases for TPPP2 Gene

Aliases for TPPP2 Gene

  • Tubulin Polymerization-Promoting Protein Family Member 2 2 3
  • Protein P25-Beta 3 4
  • TPPP/P18 3 4
  • C14orf8 3 4
  • Chromosome 14 Open Reading Frame 8 2
  • P25beta 3
  • CT152 3
  • P18 3

External Ids for TPPP2 Gene

Previous Symbols for TPPP2 Gene

  • C14orf8

Summaries for TPPP2 Gene

GeneCards Summary for TPPP2 Gene

TPPP2 (Tubulin Polymerization-Promoting Protein Family Member 2) is a Protein Coding gene. An important paralog of this gene is TPPP3.

UniProtKB/Swiss-Prot for TPPP2 Gene

  • May bind tubulin but has no microtubule bundling activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPPP2 Gene

Genomics for TPPP2 Gene

Genomic Location for TPPP2 Gene

Start:
21,024,109 bp from pter
End:
21,036,276 bp from pter
Size:
12,168 bases
Orientation:
Plus strand

Genomic View for TPPP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPPP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPPP2 Gene

Regulatory Elements for TPPP2 Gene

Proteins for TPPP2 Gene

  • Protein details for TPPP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59282-TPPP2_HUMAN
    Recommended name:
    Tubulin polymerization-promoting protein family member 2
    Protein Accession:
    P59282
    Secondary Accessions:
    • Q2VYF3

    Protein attributes for TPPP2 Gene

    Size:
    170 amino acids
    Molecular mass:
    18503 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TPPP2 Gene

Proteomics data for TPPP2 Gene at MOPED

Post-translational modifications for TPPP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TPPP2 Gene

No data available for DME Specific Peptides for TPPP2 Gene

Domains for TPPP2 Gene

Protein Domains for TPPP2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TPPP2_HUMAN
Family:
  • Belongs to the TPPP family.:
    • P59282
genes like me logo Genes that share domains with TPPP2: view

No data available for Gene Families for TPPP2 Gene

Function for TPPP2 Gene

Molecular function for TPPP2 Gene

UniProtKB/Swiss-Prot Function: May bind tubulin but has no microtubule bundling activity.

Phenotypes for TPPP2 Gene

GenomeRNAi human phenotypes for TPPP2:
genes like me logo Genes that share phenotypes with TPPP2: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TPPP2 Gene

Localization for TPPP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPPP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPPP2 Gene COMPARTMENTS Subcellular localization image for TPPP2 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TPPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TPPP2: view

Pathways for TPPP2 Gene

SuperPathways for TPPP2 Gene

No Data Available

Interacting Proteins for TPPP2 Gene

Gene Ontology (GO) - Biological Process for TPPP2 Gene

None

No data available for Pathways by source for TPPP2 Gene

Transcripts for TPPP2 Gene

Unigene Clusters for TPPP2 Gene

Tubulin polymerization-promoting protein family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPPP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5: - - - -

Relevant External Links for TPPP2 Gene

GeneLoc Exon Structure for
TPPP2
ECgene alternative splicing isoforms for
TPPP2

Expression for TPPP2 Gene

mRNA expression in normal human tissues for TPPP2 Gene

mRNA differential expression in normal tissues according to GTEx for TPPP2 Gene

This gene is overexpressed in Testis (48.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TPPP2 Gene

SOURCE GeneReport for Unigene cluster for TPPP2 Gene Hs.406966

mRNA Expression by UniProt/SwissProt for TPPP2 Gene

P59282-TPPP2_HUMAN
Tissue specificity: Expressed in spermatids. Detected in liver cancer (at protein level).
genes like me logo Genes that share expressions with TPPP2: view

Orthologs for TPPP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPPP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPPP2 36
  • 99.41 (n)
  • 100 (a)
TPPP2 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TPPP2 36
  • 89.29 (n)
  • 91.67 (a)
TPPP2 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPPP2 36
  • 86.31 (n)
  • 89.29 (a)
TPPP2 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tppp2 36
  • 83.14 (n)
  • 84.12 (a)
Tppp2 16
Tppp2 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TPPP2 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tppp2 36
  • 84.71 (n)
  • 87.65 (a)
chicken
(Gallus gallus)
Aves TPPP2 36
  • 69.7 (n)
  • 65.45 (a)
TPPP2 37
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TPPP2 37
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TPPP2 37
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4893 37
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C32E8.3 36
  • 51.23 (n)
  • 43.21 (a)
C32E8.3 37
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
OneToMany
Species with no ortholog for TPPP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TPPP2 Gene

ENSEMBL:
Gene Tree for TPPP2 (if available)
TreeFam:
Gene Tree for TPPP2 (if available)

Paralogs for TPPP2 Gene

Paralogs for TPPP2 Gene

Selected SIMAP similar genes for TPPP2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TPPP2: view

Variants for TPPP2 Gene

Sequence variations from dbSNP and Humsavar for TPPP2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
VAR_059147 -

Structural Variations from Database of Genomic Variants (DGV) for TPPP2 Gene

Variant ID Type Subtype PubMed ID
nsv428293 CNV Gain+Loss 18775914
nsv832740 CNV Gain 17160897

Relevant External Links for TPPP2 Gene

HapMap Linkage Disequilibrium report
TPPP2

Disorders for TPPP2 Gene

No disorders were found for TPPP2 Gene.

No data available for UniProtKB/Swiss-Prot for TPPP2 Gene

Publications for TPPP2 Gene

  1. Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. (PMID: 17105200) Vincze O. … Ovadi J. (Biochemistry 2006) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. (PMID: 15590652) Lindersson E. … Jensen P.H. (J. Biol. Chem. 2005) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for TPPP2 Gene

Sources for TPPP2 Gene

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