Aliases for TPPP2 Gene
Aliases for TPPP2 Gene
External Ids for TPPP2 Gene
- HGNC: 19293
- Entrez Gene: 122664
- Ensembl: ENSG00000179636
- OMIM: 616956
- UniProtKB: P59282
Previous HGNC Symbols for TPPP2 Gene
- C14orf8
Previous GeneCards Identifiers for TPPP2 Gene
- GC14P020569
- GC14P021498
- GC14P001619
- GC14P021031
- GC14P021033
- GC14P021043
- GC14P021049
Summaries for TPPP2 Gene
GeneCards Summary for TPPP2 Gene
TPPP2 (Tubulin Polymerization Promoting Protein Family Member 2) is a Protein Coding gene. An important paralog of this gene is TPPP3.
UniProtKB/Swiss-Prot for TPPP2 Gene
-
May bind tubulin but has no microtubule bundling activity.
No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPPP2 Gene
Genomics for TPPP2 Gene
Regulatory Elements for TPPP2 Gene
Enhancers for TPPP2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around TPPP2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the TPPP2 gene promoter:
Regulatory Element Products
Genomic Location for TPPP2 Gene
- Chromosome:
- 14
- Start:
- 21,024,109 bp from pter
- End:
- 21,036,352 bp from pter
- Size:
- 12,244 bases
- Orientation:
- Plus strand
Genomic View for TPPP2 Gene
Genes around TPPP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q11.2 by Ensembl
- 14q11.2 by Entrez Gene
- 14q11.2 by HGNC
TPPP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TPPP2 Gene
Proteins for TPPP2 Gene
-
Protein details for TPPP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P59282-TPPP2_HUMAN
- Recommended name:
- Tubulin polymerization-promoting protein family member 2
- Protein Accession:
- P59282
- Q2VYF3
Protein attributes for TPPP2 Gene
- Size:
- 170 amino acids
- Molecular mass:
- 18503 Da
- Quaternary structure:
- No Data Available
Protein Expression for TPPP2 Gene
Post-translational modifications for TPPP2 Gene
Other Protein References for TPPP2 Gene
Antibody Products
- Novus Biologicals Antibodies for TPPP2
- Invitrogen Antibodies for TPPP2
- antibodies-online Antibodies for TPPP2: See all 5
- Search GeneTex for Antibodies for TPPP2
Protein Products
-
OriGene Purified Proteins for TPPP2
- Search Origene for MassSpec and Protein Over-expression Lysates for TPPP2
- Origene Custom Protein Services for TPPP2
- Sino Biological Recombinant Proteins for TPPP2
- Browse Sino Biological Cell Lysates
- antibodies-online Proteins for TPPP2: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for TPPP2
Assay Products
No data available for DME Specific Peptides for TPPP2 Gene
Domains & Families for TPPP2 Gene
Gene Families for TPPP2 Gene
Protein Domains for TPPP2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TPPP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P59282- Family:
-
- Belongs to the TPPP family.
Function for TPPP2 Gene
Molecular function for TPPP2 Gene
- UniProtKB/Swiss-Prot Function:
- May bind tubulin but has no microtubule bundling activity.
Phenotypes for TPPP2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TPPP2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TPPP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TPPP2 gene
- Search ViGene Biosciences for TPPP2
CRISPR Products
-
OriGene CRISPR knockouts for TPPP2
- GenScript: Design CRISPR guide RNA sequences for TPPP2
miRNA Products
- Search ViGene Biosciences for TPPP2
Clone Products
- Sino Biological Human cDNA Clone for TPPP2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TPPP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TPPP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for TPPP2
-
ViGene Biosciences adenoviral particle packaged cDNA for TPPP2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TPPP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TPPP2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TPPP2 Gene
Localization for TPPP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TPPP2 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| nucleus | 2 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for TPPP2 Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for TPPP2 Gene
Drugs & Compounds for TPPP2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| CHM 1 | Pharma | Tubulin polymerization inhibitor | 0 |
(1) ApexBio Compounds for TPPP2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CHM 1 | Tubulin polymerization inhibitor | 154554-41-3 |
Drug Products
- ApexBio compounds for TPPP2
Transcripts for TPPP2 Gene
mRNA/cDNA for TPPP2 Gene
- (7) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (44) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TPPP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TPPP2
- GenScript: Design CRISPR guide RNA sequences for TPPP2
miRNA Products
- Search ViGene Biosciences for TPPP2
Clone Products
- Sino Biological Human cDNA Clone for TPPP2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TPPP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TPPP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||
| SP5: | - | - | - | - |
Expression for TPPP2 Gene
mRNA differential expression in normal tissues according to GTEx for TPPP2 Gene
This gene is overexpressed in Testis (x48.5).
This gene is overexpressed in Testis (28.5), Skin (15.1), Ovary (14.4), and Heart (11.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TPPP2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TPPP2 Gene:
TPPP2SOURCE GeneReport for Unigene cluster for TPPP2 Gene:
Hs.406966mRNA Expression by UniProt/SwissProt for TPPP2 Gene:
P59282-TPPP2_HUMAN
Tissue specificity:
Expressed in spermatids. Detected in liver cancer (at protein level).
Primer Products
-
OriGene qPCR primer pairs for TPPP2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TPPP2 Gene
Orthologs for TPPP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TPPP2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | TPPP2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | TPPP2 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tppp2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tppp2 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TPPP2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TPPP2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TPPP2 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | TPPP2 35 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG4893 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | C32E8.3 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for TPPP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for TPPP2 Gene
(3) SIMAP similar genes for TPPP2 Gene using alignment to 6 proteins:
Variants for TPPP2 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10138807 | -- | 21,024,151(+) | TCTTT(C/T)AGGGA | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs10144197 | -- | 21,029,417(+) | ccaac(A/G)tggca | intron-variant, upstream-variant-2KB | |
| rs10146059 | -- | 21,035,066(+) | AGAGC(A/G)TTCGC | intron-variant, upstream-variant-2KB | |
| rs10150271 | -- | 21,033,243(+) | GAAGG(A/G)AGAAA | intron-variant, downstream-variant-500B, utr-variant-3-prime | |
| rs111247802 | -- | 21,033,681(+) | ACATT(G/T)TCGCA | intron-variant, utr-variant-3-prime |
Residual Variation Intolerance Score:
88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.49;
82.16% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TPPP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TPPP2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPPP2 Gene
Disorders for TPPP2 Gene
Relevant External Links for TPPP2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- TPPP2
No disorders were found for TPPP2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPPP2 Gene
Publications for TPPP2 Gene
- Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. (PMID: 17105200) Vincze O. … Ovadi J. (Biochemistry 2006) 2 3 4 64
- p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. (PMID: 15590652) Lindersson E. … Jensen P.H. (J. Biol. Chem. 2005) 2 3 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Scanning of novel cancer/testis proteins by human testis proteomic analysis. (PMID: 23436708) Liu M. … Sha J. (Proteomics 2013) 4 64
- Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
Products for TPPP2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TPPP2
- Search Origene for MassSpec and Protein Over-expression Lysates for TPPP2
- Origene Custom Protein Services for TPPP2
- Origene rat_shrna, mouse_rna, siRNA, shRNA, and RNAi products in human, mouse, rat for TPPP2
- Browse OriGene Inhibitory RNA Products For TPPP2
- OriGene qPCR primer pairs for TPPP2
- OriGene CRISPR knockouts for TPPP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TPPP2
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for TPPP2
- GenScript Custom Assay Services for TPPP2
- GenScript Custom overexpressing Cell Line Services for TPPP2
- GenScript: Design CRISPR guide RNA sequences for TPPP2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TPPP2
- Sino Biological Human cDNA Clone for TPPP2
- Sino Biological Recombinant Proteins for TPPP2
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for TPPP2
- Novus Biologicals proteins and lysates for TPPP2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for TPPP2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for TPPP2
- antibodies-online Antibodies for TPPP2: See all 5
- Search antibodies-online for kits
- antibodies-online Proteins for TPPP2: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for TPPP2
- Search GeneTex for Proteins for TPPP2
- ViGene Biosciences adenoviral particle packaged cDNA for TPPP2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TPPP2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TPPP2 gene
- Search ViGene Biosciences for TPPP2
- Horizon Cell Lines for TPPP2
- Cyagen custom Knockout/knockin (KOKI) mouse models for TPPP2
- VectorBuilder custom plasmid, inducible vectors for TPPP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TPPP2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for TPPP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab