TPPP2 Gene

Aliases
for TPPP2 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC14P020569 GC14P001619

Summaries
for TPPP2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for TPPP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000014.8  NT_026437.13  NC_018925.2  

SwitchGear Promoter luciferase reporter plasmid: TPPP2 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPPP2

TPPP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021498:  view genomic region     (about GC identifiers)

Proteins
for TPPP2 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for TPPP2: NX_P59282

Explore proteomics data for TPPP2 at MOPED

Post-translational modifications: 

TPPP2 Human Recombinant Protein Products:

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TPPP2 Assay Products:

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	antibodies-online kits for TPPP2 (6 products)

Domains /
Families
for TPPP2 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P59282

Find genes that share domains with TPPP2           About GenesLikeMe

Function
for TPPP2 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Phenotypes:
     1 GenomeRNAi human phenotype for TPPP2:

genOway: Develop your customized and physiologically relevant rodent model for TPPP2

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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TPPP2

Clone Products:		OriGene clones in human, mouse for TPPP2 (see all 6) OriGene ORF clones in mouse, rat for TPPP2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TPPP2 (NM_173846)
		Sino Biological Human cDNA Clone for TPPP2
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPPP2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TPPP2
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPPP2

Localization
for TPPP2 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytosol	3
nucleus	2
extracellular	1

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for TPPP2 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Drugs & Compounds
for TPPP2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for TPPP2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for TPPP2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TPPP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTTAACACCA

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for TPPP2
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TPPP2
		QuantiTect SYBR Green Assays in human, mouse, rat TPPP2
		QuantiFast Probe-based Assays in human, mouse, rat TPPP2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPPP2

Orthologs
for TPPP2 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for TPPP2 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for TPPP2 gene

TPPP²  TPPP3²  

3 SIMAP similar genes for TPPP2 using alignment to 6 protein entries:     TPPP2_HUMAN (see all proteins):

TPPP3    FREP1    TPPP

Find genes that share paralogs with TPPP2           About GenesLikeMe

Genomic Variants
for TPPP2 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TPPP2 (see all 135)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs720632811,2	C	--	21496401(+)	TTCTT-/TTTTG          TTTGT	1	--	us2k1		0	--	--	--	--
rs711125411,2	C	--	21496404(+)	GTTTTGTTTT/-          TGAGA	1	--	us2k1		1		NA	2
rs735838941,2	C,F	--	21496441(+)	GGGGTC/GTCTCT	1	--	us2k1		3		WA CSA	122
rs559705311,2	C,F	--	21496653(+)	TAGGCA/GTGAGC	1	--	us2k1		4		WA NA	242
rs1864779471,2		--	21496792(+)	ATATCC/TTGAGC	1	--	us2k1		0	--	--	--	--
rs12434561,2	C,F,H	--	21496800(+)	AGCCAT/CAGAAT	1	--	us2k1		13		NA WA CSA EA	376
rs800096281,2	F	--	21497105(+)	GATCCG/ATGAGG	1	--	us2k1		1		WA	118
rs1504390561,2		--	21497126(+)	TGTAGA/TGCTTC	1	--	us2k1		0	--	--	--	--
rs1380229511,2	C	--	21497185(+)	CCTGCA/GTAGAA	1	--	us2k1		0	--	--	--	--
rs1495226281,2		--	21497219(+)	CTGAGA/CCTCAC	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for TPPP2 (21492268 - 21504435 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for TPPP2:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv832740	CNV	Gain	17160897
nsv428293	CNV	Gain+Loss	18775914

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TPPP2

DNA2.0 Custom Variant and Variant Library Synthesis for TPPP2

Disorders / Diseases
for TPPP2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for TPPP2 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. (PubMed id 17105200)^{1, 2, 3} Vincze O....Ovadi J. (Biochemistry 2006)
2. p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. (PubMed id 15590652)^{1, 3} Lindersson E.... Jensen P.H. (J. Biol. Chem. 2005)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
4. Scanning of novel cancer/testis proteins by human testis proteomic analysis. (PubMed id 23436708)² Liu M....Sha J. (Proteomics 2013)
5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (amp 2008)
6. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)² Heilig R.... Weissenbach J. (Nature 2003)
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
8. (PubMed id )² 

External Searches for TPPP2 gene

Genome Databases showing TPPP2 gene

Other Databases showing TPPP2 gene

Specialized Databases showing TPPP2 gene

Products
for TPPP2 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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