Aliases for TPPP2 Gene
Aliases for TPPP2 Gene
External Ids for TPPP2 Gene
- HGNC: 19293
- Entrez Gene: 122664
- Ensembl: ENSG00000179636
- OMIM: 616956
- UniProtKB: P59282
Previous HGNC Symbols for TPPP2 Gene
- C14orf8
Previous GeneCards Identifiers for TPPP2 Gene
- GC14P020569
- GC14P021498
- GC14P001619
- GC14P021031
- GC14P021033
- GC14P021043
- GC14P021049
- GC14P021061
- GC14P021069
- GC14P021081
Summaries for TPPP2 Gene
GeneCards Summary for TPPP2 Gene
TPPP2 (Tubulin Polymerization Promoting Protein Family Member 2) is a Protein Coding gene. An important paralog of this gene is TPPP3.
UniProtKB/Swiss-Prot for TPPP2 Gene
-
May bind tubulin but has no microtubule bundling activity.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPPP2 Gene
Genomics for TPPP2 Gene
GeneHancer (GH) Regulatory Elements for TPPP2 Gene
Promoters and enhancers for TPPP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TPPP2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TPPP2 gene promoter:
Regulatory Element Products
Genomic Locations for TPPP2 Gene
Genomic Locations for TPPP2 Gene
- chr14:21,024,109-21,036,352
- (GRCh38/hg38)
- Size:
- 12,244 bases
- Orientation:
- Plus strand
- chr14:21,492,268-21,504,435
- (GRCh37/hg19)
Genomic View for TPPP2 Gene
Genes around TPPP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q11.2 by Ensembl
- 14q11.2 by Entrez Gene
- 14q11.2 by HGNC
TPPP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TPPP2 Gene
Proteins for TPPP2 Gene
-
Protein details for TPPP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P59282-TPPP2_HUMAN
- Recommended name:
- Tubulin polymerization-promoting protein family member 2
- Protein Accession:
- P59282
- Q2VYF3
Protein attributes for TPPP2 Gene
- Size:
- 170 amino acids
- Molecular mass:
- 18503 Da
- Quaternary structure:
- No Data Available
Protein Expression for TPPP2 Gene
Post-translational modifications for TPPP2 Gene
No Post-translational modifications
Other Protein References for TPPP2 Gene
Antibody Products
- Novus Biologicals Antibodies for TPPP2
- Invitrogen Antibodies for TPPP2
- Search GeneTex for Antibodies for TPPP2
- Sino Biological Antibodies for TPPP2
Protein Products
-
OriGene Purified Proteins for TPPP2
- Search Origene for MassSpec and Protein Over-expression Lysates for TPPP2
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- Sino Biological Recombinant Proteins for TPPP2
- Browse Sino Biological Cell Lysates
- antibodies-online: Search results for 4 available TPPP2 Proteins ranked by validation data
- Compare Top TPPP2 Proteins
-
Quality Products:
- Search GeneTex for Proteins for TPPP2
Assay Products
No data available for DME Specific Peptides for TPPP2 Gene
Domains & Families for TPPP2 Gene
Gene Families for TPPP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TPPP2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TPPP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P59282- Family:
-
- Belongs to the TPPP family.
Function for TPPP2 Gene
Molecular function for TPPP2 Gene
- UniProtKB/Swiss-Prot Function:
- May bind tubulin but has no microtubule bundling activity.
Phenotypes From GWAS Catalog for TPPP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0015631 | tubulin binding | IDA | 17105200 |
Phenotypes for TPPP2 Gene
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for TPPP2 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for TPPP2
- genomics-online: gRNA clones - Search results for 96 available TPPP2 gene related products
- Overview of 96 available TPPP2 gene related products
- Applied Biological Materials CRISPR for TPPP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TPPP2
- GenScript: Design CRISPR guide RNA sequences for TPPP2
miRNA Products
- Search ViGene Biosciences for TPPP2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TPPP2
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- genomics-online: shRNA clones - Search results for 96 available TPPP2 gene related products
- Overview of 96 available TPPP2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TPPP2 gene
Clone Products
- Sino Biological Human cDNA Clone for TPPP2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Applied Biological Materials Clones for TPPP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TPPP2
-
ViGene Biosciences adenoviral particle packaged cDNA for TPPP2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TPPP2 gene
-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TPPP2 Gene
Localization for TPPP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TPPP2 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 2 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | IDA | 17105200 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TPPP2 Gene
Pathways & Interactions for TPPP2 Gene
No Data Available
Interacting Proteins for TPPP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001578 | NOT microtubule bundle formation | IMP | 17105200 |
No data available for Pathways by source and SIGNOR curated interactions for TPPP2 Gene
Drugs & Compounds for TPPP2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| CHM 1 | Pharma | Tubulin polymerization inhibitor | 0 |
(1) ApexBio Compounds for TPPP2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CHM 1 | Tubulin polymerization inhibitor | 154554-41-3 |
Transcripts for TPPP2 Gene
mRNA/cDNA for TPPP2 Gene
- (7) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (44) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TPPP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TPPP2
- genomics-online: gRNA clones - Search results for 96 available TPPP2 gene related products
- Overview of 96 available TPPP2 gene related products
- Applied Biological Materials CRISPR for TPPP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TPPP2
- GenScript: Design CRISPR guide RNA sequences for TPPP2
miRNA Products
- Search ViGene Biosciences for TPPP2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TPPP2
- Browse OriGene Inhibitory RNA Products For TPPP2
- genomics-online: shRNA clones - Search results for 96 available TPPP2 gene related products
- Overview of 96 available TPPP2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TPPP2 gene
Clone Products
- Sino Biological Human cDNA Clone for TPPP2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Applied Biological Materials Clones for TPPP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||
| SP5: | - | - | - | - |
Expression for TPPP2 Gene
mRNA differential expression in normal tissues according to GTEx for TPPP2 Gene
This gene is overexpressed in Testis (x48.5).
This gene is overexpressed in Testis (28.5), Skin (15.1), Ovary (14.4), and Heart (11.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TPPP2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TPPP2 Gene:
TPPP2SOURCE GeneReport for Unigene cluster for TPPP2 Gene:
Hs.406966mRNA Expression by UniProt/SwissProt for TPPP2 Gene:
P59282-TPPP2_HUMAN
Tissue specificity:
Expressed in spermatids. Detected in liver cancer (at protein level).
Evidence on tissue expression from TISSUES for TPPP2 Gene
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs for TPPP2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPPP2 Gene
Orthologs for TPPP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TPPP2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TPPP2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TPPP2 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tppp2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Tppp2 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TPPP2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TPPP2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TPPP2 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | TPPP2 34 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG4893 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | C32E8.3 33 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for TPPP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for TPPP2 Gene
(3) SIMAP similar genes for TPPP2 Gene using alignment to 6 proteins:
Variants for TPPP2 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000119394 | -- | 21,032,810(+) | G/A | 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant | |
| rs1000975098 | -- | 21,022,765(+) | G/A | upstream_transcript_variant | |
| rs1001034548 | -- | 21,030,196(+) | C/T | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1001107937 | -- | 21,030,029(+) | G/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1001457179 | -- | 21,024,285(+) | T/C | 5_prime_UTR_variant, genic_upstream_transcript_variant |
Residual Variation Intolerance Score:
88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.49;
82.16% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TPPP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TPPP2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPPP2 Gene
Disorders for TPPP2 Gene
Additional Disease Information for TPPP2
No disorders were found for TPPP2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPPP2 Gene
Publications for TPPP2 Gene
- Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. (PMID: 17105200) Vincze O … Ovádi J (Biochemistry 2006) 2 3 4 58
- p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. (PMID: 15590652) Lindersson E … Jensen PH (The Journal of biological chemistry 2005) 2 3 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Scanning of novel cancer/testis proteins by human testis proteomic analysis. (PMID: 23436708) Liu M … Sha J (Proteomics 2013) 4 58
- Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58
Products for TPPP2 Gene
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- Invitrogen Antibodies for TPPP2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for TPPP2
- antibodies-online: Search results for 7 available TPPP2 Antibodies ranked by validation data
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- antibodies-online: Search results for 4 available TPPP2 Proteins ranked by validation data
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- Quality Products:
- Search GeneTex for Antibodies for TPPP2
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- ViGene Biosciences adenoviral particle packaged cDNA for TPPP2 gene
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- genomics-online: cdna clones - Search results for 96 available TPPP2 gene related products
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- orf clones - Search results for 96 available TPPP2 gene related products
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- Overview of 96 available TPPP2 gene related products
- genomics-online: primer clones - Search results for 96 available TPPP2 gene related products
- Overview of 96 available TPPP2 gene related products
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- Overview of 96 available TPPP2 gene related products
Sources for TPPP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew