TPPP2 Gene
protein-coding GIFtS: 43
GCID: GC14P021498
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Tubulin Polymerization-Promoting Protein Family Member 2(Previous name: chromosome 14 open reading frame 8)
(Previous symbol: C14orf8)
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Aliases
for TPPP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| Tubulin Polymerization-Promoting Protein Family Member 21 2 | | Chromosome 14 Open Reading Frame 81 | | C14orf81 2 3 | | P182 | | Protein P25-Beta2 3 | | p25beta2 | | TPPP/p182 3 | | |
Export aliases for TPPP2 gene to outside databasesPrevious GC identifers: GC14P020569 GC14P001619 |
Summaries
for TPPP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
GeneCards Summary for TPPP2 Gene: 
TPPP2 (tubulin polymerization-promoting protein family member 2) is a protein-coding gene. An important paralog of this gene is TPPP.
UniProtKB/Swiss-Prot: TPPP2_HUMAN, P59282Function: May bind tubulin but has no microtubule bundling activity
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Genomic Views
for TPPP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NT_026437.12 NC_018925.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TPPP2 gene promoter:
RP58 Nkx2-5 CREB PPAR-gamma1 c-Rel deltaCREB ARP-1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TPPP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPPP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2TPPP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P021498: view genomic region
(about GC identifiers)
Start:
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21,492,268 bp from pter |
End:
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21,504,435 bp from pter |
Size:
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12,168 bases |
Orientation:
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plus strand |
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Proteins
for TPPP2 gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
|
UniProtKB/Swiss-Prot: TPPP2_HUMAN, P59282 (See
protein sequence)Recommended Name: Tubulin polymerization-promoting protein family member 2 Size: 170 amino acids; 18503 Da
Subcellular location: Cytoplasm (Probable)
Secondary accessions: Q2VYF3Explore the universe of human proteins at neXtProt for TPPP2: NX_P59282
Explore proteomics data for TPPP2 at MOPED
Post-translational modifications:
View modification sites using PhosphoSitePlusView neXtProt modification sites for NX_P59282
TPPP2 Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins: NP_776245.2
ENSEMBL proteins: ENSP00000317595 ENSP00000427504 ENSP00000435356 ENSP00000423171 ENSP00000421438 ENSP00000436874 ENSP00000451899
Human Recombinant Protein Products for TPPP2:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
TPPP2 for ontologies About GeneDecksing
TPPP2 Antibody Products:
Assay Products for TPPP2: |
Protein
Domains /
Families
for TPPP2 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| 1 InterPro protein domain:Graphical View of Domain Structure for InterPro Entry P59282 ProtoNet protein and cluster: P59282 1 Blocks protein domain: IPB008907 P25-alpha
UniProtKB/Swiss-Prot: TPPP2_HUMAN, P59282Similarity: Belongs to the TPPP family
TPPP2 for domains About GeneDecksing
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Function
for TPPP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
Vector BioLabs,
and Sirion Biotech,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
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Molecular Function:
UniProtKB/Swiss-Prot Summary: TPPP2_HUMAN, P59282Function: May bind tubulin but has no microtubule bundling activityPhenotypes:
1 GenomeRNAi human phenotype for TPPP2:
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for TPPP2 | |  | Search LifeMap BioReagents cell lines for TPPP2 | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPPP2 |
Pathways & Interactions
for TPPP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TPPP2
|
Drugs & Compounds
for TPPP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TPPP2
Search CenterWatch for drugs/clinical trials and news about TPPP2
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Transcripts
for TPPP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Sirion Biotech,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for TPPP2 gene: NM_173846.4 Unigene Cluster for TPPP2: Tubulin polymerization-promoting protein family member 2 Hs.406966 [show with all ESTs]Unigene Representative Sequence: AK09307012 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000533755 ENST00000534434(uc001vzh.3) ENST00000525425 ENST00000321760
ENST00000532060 ENST00000460647 ENST00000530140 ENST00000472458 ENST00000481535
ENST00000529496 ENST00000495665 ENST00000555751
Primer
Products: |  | OriGene qSTAR qPCR primer pairs in human, mouse for TPPP2
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TPPP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPPP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPPP2 |
Additional mRNA sequence: AK093070.1 AK098680.1 AY072034.1 AY173946.1 BC027610.1 BC038970.2 BC064583.1 8 DOTS entries: DT.308753 DT.102821889 DT.100714385 DT.116983 DT.120755924 DT.120755926 DT.86852168 DT.70103724 24/44 AceView cDNA sequences (see all 44): AI990760 AW135537 AI915840 AI190550 AK098680 BC027610 AA812901 AA448281 BV190339 BG724262 NM_173846 AY072034 BC064583 AK093070 AW511240 BM554263 BI463289 AI187284 AA861291 BE501240 AI219847 BC038970 AA913948 AI633873
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TPPP2 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5 |
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| SP1: | | | | | | | - | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | - | | - | | | |
ECgene alternative splicing isoforms for TPPP2
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Expression
for TPPP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TPPP2 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTAACACCA
About this image
See TPPP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TPPP2
SOURCE GeneReport for Unigene cluster: Hs.406966
SABiosciences Custom PCR Arrays for TPPP2
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for TPPP2
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TPPP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPPP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPPP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPPP2 |
Orthologs
for TPPP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TPPP2 gene from 6/12 species (see all 12) About this table
ENSEMBL Gene Tree for TPPP2 (if available)
TreeFam Gene Tree for TPPP2 (if available) |
Paralogs
for TPPP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TPPP2 gene
- TPPP2 TPPP32
3 SIMAP similar genes for TPPP2 using alignment to 6 protein entries: TPPP2_HUMAN (see all proteins):TPPP3 FREP1 TPPP
TPPP2 for paralogs About GeneDecksing
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Genomic Variants
for TPPP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TPPP2 (21492268 - 21504435 bp)
Structural Variations
Database of Genomic Variants (DGV) 2 variations for TPPP2: About this table
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPPP2 |
|
Disorders
/ Diseases
for TPPP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TPPP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TPPP2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TPPP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. (PubMed id 17105200)1, 2, 3 Vincze O....Ovadi J. (2006)
- p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. (PubMed id 15590652)1, 3 Lindersson E....Jensen P.H. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for TPPP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TPPP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing TPPP2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TPPP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TPPP2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for TPPP2 gene:
Search GeneIP for patents involving TPPP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TPPP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TPPP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPPP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPPP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TPPP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPPP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPPP2 |
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 |  |  |  | |
| | | | Search Tocris compounds for TPPP2 |
| |  |  |  |  | | | | |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPPP2 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TPPP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPPP2 |
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