Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneAnalytics
- GeneLoc
- GenesLikeMe
- VarElect
- PathCards
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

TPPP2 Gene

protein-coding GIFtS: 43
GCID: GC14P021498

Tubulin Polymerization-Promoting Protein Family Member 2

(Previous name: chromosome 14 open reading frame 8)
(Previous symbol: C14orf8)

See TPPP2-related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
Tubulin Polymerization-Promoting Protein Family Member 2¹ ²		Chromosome 14 Open Reading Frame 8¹
C14orf8¹ ² ³		CT152²
Protein P25-Beta² ³		P18²
TPPP/p18² ³		p25beta²

External Ids:	HGNC: 19293¹	Entrez Gene: 122664²	Ensembl: ENSG00000179636⁷	UniProtKB: P59282³

Export aliases for TPPP2 gene to outside databases

Previous GC identifers: GC14P020569 GC14P001619

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for TPPP2 Gene:

TPPP2 (tubulin polymerization-promoting protein family member 2) is a protein-coding gene. Diseases associated with TPPP2 include liver cancer. An important paralog of this gene is TPPP.

UniProtKB/Swiss-Prot: TPPP2_HUMAN, P59282

Function: May bind tubulin but has no microtubule bundling activity

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence at NCBI GenBank:

NC_000014.8 NT_026437.13 NC_018925.2

Regulatory elements:

Regulatory transcription factor binding sites in the TPPP2 gene promoter:
RP58 Nkx2-5 CREB PPAR-gamma1 c-Rel deltaCREB ARP-1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TPPP2 promoter sequence

Search Chromatin IP Primers for TPPP2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPPP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2

TPPP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPPP2 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P021498: view genomic region (about GC identifiers)

Start:	21,492,268 bp from pter	End:	21,504,435 bp from pter
Size:	12,168 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TPPP2_HUMAN, P59282 (See protein sequence)

Recommended Name: Tubulin polymerization-promoting protein family member 2

Size: 170 amino acids; 18503 Da

Secondary accessions: Q2VYF3

Explore the universe of human proteins at neXtProt for TPPP2: NX_P59282

Explore proteomics data for TPPP2 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See TPPP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_776245.2

ENSEMBL proteins:

ENSP00000317595 ENSP00000427504 ENSP00000435356 ENSP00000423171 ENSP00000421438

ENSP00000436874 ENSP00000451899

TPPP2 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for TPPP2 OriGene Protein Over-expression Lysate for TPPP2 OriGene MassSpec for TPPP2 OriGene Custom Protein Services for TPPP2
	GenScript Custom Purified and Recombinant Proteins Services for TPPP2
	Novus Biologicals TPPP2 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for TPPP2
	Search eBioscience for Proteins for TPPP2
	antibodies-online proteins for TPPP2
	Search antibodies-online for peptides for TPPP2

TPPP2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for TPPP2
	Novus Biologicals TPPP2 Antibody
	Abcam antibodies for TPPP2
	Cloud-Clone Corp. Antibodies for TPPP2
	Search ThermoFisher Antibodies for TPPP2
	antibodies-online antibodies for TPPP2 (2 products)

TPPP2 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for TPPP2
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TPPP2
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for TPPP2 Cloud-Clone Corp. CLIAs for TPPP2
	Search eBioscience for ELISAs for TPPP2
	antibodies-online kits for TPPP2 (6 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

1 InterPro protein domain:

IPR008907 P25-alpha

Graphical View of Domain Structure for InterPro Entry P59282

ProtoNet protein and cluster: P59282

1 Blocks protein domain: IPB008907 P25-alpha

UniProtKB/Swiss-Prot: TPPP2_HUMAN, P59282

Similarity: Belongs to the TPPP family

Find genes that share domains with TPPP2 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: TPPP2_HUMAN, P59282

Function: May bind tubulin but has no microtubule bundling activity

Phenotypes:
1 GenomeRNAi human phenotype for TPPP2:

Decreased viability with pacli

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for TPPP2

miRNA Products:		Block miRNA regulation of human, mouse, rat TPPP2 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate TPPP2
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TPPP2
		Predesigned siRNA for gene silencing in human, mouse, rat TPPP2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TPPP2

Clone Products:		OriGene clones in human, mouse for TPPP2 (see all 6) OriGene ORF clones in mouse, rat for TPPP2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TPPP2 (NM_173846)
		Sino Biological Human cDNA Clone for TPPP2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TPPP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPPP2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TPPP2
		Browse ESI BIO Cell Lines and PureStem Progenitors for TPPP2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPPP2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot

TPPP2_HUMAN, P59282: Cytoplasm (Probable)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	3
nucleus	2
extracellular	1

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

Find genes that share ontologies with TPPP2 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for TPPP2
Interactions:

Search GeneGlobe Interaction Network for TPPP2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for TPPP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for TPPP2 gene:

NM_173846.4

Unigene Cluster for TPPP2:

Tubulin polymerization-promoting protein family member 2

Hs.406966 [show with all ESTs]

Unigene Representative Sequence: AK093070

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000533755 ENST00000534434(uc001vzh.3) ENST00000525425 ENST00000321760

ENST00000532060 ENST00000460647 ENST00000530140 ENST00000472458 ENST00000481535

ENST00000529496 ENST00000495665 ENST00000555751

miRNA Products:		Block miRNA regulation of human, mouse, rat TPPP2 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate TPPP2
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TPPP2
		Predesigned siRNA for gene silencing in human, mouse, rat TPPP2

Clone Products:		OriGene clones in human, mouse for TPPP2 (see all 6) OriGene ORF clones in mouse, rat for TPPP2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TPPP2 (NM_173846)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TPPP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPPP2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for TPPP2
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat TPPP2
		QuantiTect SYBR Green Assays in human, mouse, rat TPPP2
		QuantiFast Probe-based Assays in human, mouse, rat TPPP2

Additional mRNA sequence:

AK093070.1 AK098680.1 AY072034.1 AY173946.1 BC027610.1 BC038970.2 BC064583.1

8 DOTS entries:

DT.308753 DT.102821889 DT.100714385 DT.116983 DT.120755924 DT.120755926 DT.86852168 DT.70103724

Selected AceView cDNA sequences (see all 44):

AI990760 AW135537 AI915840 BX492694 BC027610 AA812901 AI806847 AA861291

AA913948 BI460527 BE501240 BI827944 NM_173846 BM554263 BV190339 AI219847

AK098680 AI633873 AA448281 BC064583 AI187284 BG724262 BI463289 AA431560

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TPPP2 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	^	5
SP1:							-								-
SP2:															-
SP3:							-								-
SP4:							-
SP5:															-		-		-		-

ECgene alternative splicing isoforms for TPPP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

TPPP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTTAACACCA

About this image

TPPP2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TPPP2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.406966

UniProtKB/Swiss-Prot: TPPP2_HUMAN, P59282

Tissue specificity: Expressed in spermatids. Detected in liver cancer (at protein level)

Custom PCR Arrays for TPPP2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for TPPP2
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat TPPP2
		QuantiTect SYBR Green Assays in human, mouse, rat TPPP2
		QuantiFast Probe-based Assays in human, mouse, rat TPPP2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPPP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for TPPP2 gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tppp2^{1 , 5}	tubulin polymerization-promoting protein family member more^{1, 5}	83.14(n)¹ 84.12(a)¹		14 (26.72 cM)⁵ 219038¹ NM_001128634.1¹ NP_001122106.1¹ 51918761⁵
chicken (Gallus gallus)	Aves	TPPP2¹	tubulin polymerization-promoting protein family member more	69.7(n) 65.45(a)		427270 XM_424853.3 XP_424853.1
lizard (Anolis carolinensis)	Reptilia	TPPP2⁶	tubulin polymerization-promoting protein family me...	66(a)	1 ↔ 1	GL343253.1(1695209-1700295)
zebrafish (Danio rerio)	Actinopterygii	TPPP2⁶	tubulin polymerization-promoting protein family me...	57(a)	1 ↔ 1	5(38661354-38665606) ENSDARG00000035338
fruit fly (Drosophila melanogaster)	Insecta	CG4893⁶	--	33(a)	1 → many	3L(16347846-16352528)
worm (Caenorhabditis elegans)	Secernentea	C32E8.3¹	C32E8.3	51.23(n) 43.21(a)		171948 NM_058818.3 NP_491219.1

ENSEMBL Gene Tree for TPPP2 (if available)
TreeFam Gene Tree for TPPP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for TPPP2 gene

TPPP² TPPP3²

3 SIMAP similar genes for TPPP2 using alignment to 6 protein entries: TPPP2_HUMAN (see all proteins):

TPPP3 FREP1 TPPP

Find genes that share paralogs with TPPP2 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72063281^1,2	C	--	21496401(+)	`TTCTT-/TTTTG TTTGT`	1	--	us2k¹		0	--	--	--	--
rs71112541^1,2	C	--	21496404(+)	`GTTTTGTTTT/- TGAGA`	1	--	us2k¹		1		NA	2
rs73583894^1,2	C,F	--	21496441(+)	`GGGGTC/GTCTCT`	1	--	us2k¹		3		WA CSA	122
rs55970531^1,2	C,F	--	21496653(+)	`TAGGCA/GTGAGC`	1	--	us2k¹		4		WA NA	242
rs186477947^1,2		--	21496792(+)	`ATATCC/TTGAGC`	1	--	us2k¹		0	--	--	--	--
rs1243456^1,2	C,F,H	--	21496800(+)	`AGCCAT/CAGAAT`	1	--	us2k¹		13		NA WA CSA EA	376
rs80009628^1,2	F	--	21497105(+)	`GATCCG/ATGAGG`	1	--	us2k¹		1		WA	118
rs150439056^1,2		--	21497126(+)	`TGTAGA/TGCTTC`	1	--	us2k¹		0	--	--	--	--
rs138022951^1,2	C	--	21497185(+)	`CCTGCA/GTAGAA`	1	--	us2k¹		0	--	--	--	--
rs149522628^1,2		--	21497219(+)	`CTGAGA/CCTCAC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TPPP2 (21492268 - 21504435 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for TPPP2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv832740	CNV	Gain	17160897
nsv428293	CNV	Gain+Loss	18775914

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TPPP2

DNA2.0 Custom Variant and Variant Library Synthesis for TPPP2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

1 disease for TPPP2:
About MalaCards

liver cancer

Find genes that share disorders with TPPP2 About GenesLikeMe

Export disorders for TPPP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for TPPP2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TPPP2)

Utopia: connect your pdf to the dynamic
world of online information

Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. (PubMed id 17105200)^{1, 2, 3} Vincze O....Ovadi J. (Biochemistry 2006)
p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. (PubMed id 15590652)^{1, 3} Lindersson E.... Jensen P.H. (J. Biol. Chem. 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Scanning of novel cancer/testis proteins by human testis proteomic analysis. (PubMed id 23436708)² Liu M....Sha J. (Proteomics 2013)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (amp 2008)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)² Heilig R.... Weissenbach J. (Nature 2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
(PubMed id )²

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 122664	HGNC: 19293	AceView: C14orf8	Ensembl:ENSG00000179636	euGenes: HUgn122664
ECgene: TPPP2	H-InvDB: TPPP2

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for TPPP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TPPP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for TPPP2 gene:
Search GeneIP for patents involving TPPP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for TPPP2
	Browse OriGene qPCR primer pairs and template standards		OriGene Protein Over-expression Lysate for TPPP2
	OriGene MassSpec for TPPP2		OriGene clones in human, mouse for TPPP2
	OriGene qSTAR qPCR primer pairs in human, mouse for TPPP2		OriGene Purified Protein for TPPP2
	OriGene ORF clones in mouse, rat for TPPP2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TPPP2		OriGene Custom Protein Services for TPPP2

	Block miRNA regulation of human, mouse, rat TPPP2 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing TPPP2
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPPP2		Predesigned siRNA for gene silencing in human, mouse, rat TPPP2
	QuantiFast Probe-based Assays in human, mouse, rat TPPP2		QuantiTect SYBR Green Assays in human, mouse, rat TPPP2
	Custom PCR Arrays for TPPP2		Search Chromatin IP Primers for TPPP2
	Pre-validated RT² qPCR Primer Assay in human, mouse / rat TPPP2		Search GeneGlobe Interaction Network for TPPP2
	Regulatory tfbs in TPPP2 promoter

	GenScript Custom Purified and Recombinant Proteins Services for TPPP2		GenScript cDNA clones with any tag delivered in your preferred vector for TPPP2
	GenScript Custom Assay Services for TPPP2		GenScript Custom overexpressing Cell Line Services for TPPP2
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for TPPP2

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	cDNA Clones for TPPP2
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TPPP2 antibodies
	TPPP2 lysates

	Antibodies for TPPP2
	See all of Abcam's Antibodies, Kits and Proteins for TPPP2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for TPPP2
	Antibodies for TPPP2
	ELISAs for TPPP2
	CLIAs for TPPP2

Browse ESI BIO Cell Lines and PureStem Progenitors for TPPP2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPPP2

	Browse SwitchGear 3'UTR luciferase reporter plasmids for TPPP2
	SwitchGear Promoter luciferase reporter plasmids for TPPP2

Search ThermoFisher Antibodies for TPPP2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPPP2

Browse compounds at ApexBio

Search Addgene for plasmids for TPPP2

	Search eBioscience for proteins for TPPP2
	Search eBioscience for elisas for TPPP2
	eBioscience FlowRNA Probe Sets

genOway: Develop your customized and physiologically relevant rodent model for TPPP2

	antibodies-online antibodies for TPPP2 (2 products)
	antibodies-online kits for TPPP2 (6 products)
	Search antibodies-online for peptides for TPPP2
	antibodies-online proteins for TPPP2

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TPPP2 gene at Home site.

Version: 3.12.300 21 Jan 2015
hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

TPPP2 Gene

Tubulin Polymerization-Promoting Protein Family Member 2

Aliases
for TPPP2 gene

Summaries
for TPPP2 gene

Genomic Views
for TPPP2 gene

Proteins
for TPPP2 gene

TPPP2 Human Recombinant Protein Products:

TPPP2 Antibody Products:

TPPP2 Assay Products:

Domains /
Families
for TPPP2 gene

Function
for TPPP2 gene

Localization
for TPPP2 gene

Pathways & Interactions
for TPPP2 gene

Drugs & Compounds
for TPPP2 gene

Transcripts
for TPPP2 gene

Expression
for TPPP2 gene

Orthologs
for TPPP2 gene

Paralogs
for TPPP2 gene

Genomic Variants
for TPPP2 gene

Disorders / Diseases
for TPPP2 gene

Publications
for TPPP2 gene

External Searches for TPPP2 gene

Genome Databases showing TPPP2 gene

Other Databases showing TPPP2 gene

Specialized Databases showing TPPP2 gene

Intellectual Property
for TPPP2 gene

Products
for TPPP2 gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

TPPP2 Gene

Tubulin Polymerization-Promoting Protein Family Member 2

Aliasesfor TPPP2 gene

Summariesfor TPPP2 gene

Genomic Viewsfor TPPP2 gene

Proteinsfor TPPP2 gene

TPPP2 Human Recombinant Protein Products:

TPPP2 Antibody Products:

TPPP2 Assay Products:

Domains /Familiesfor TPPP2 gene

Functionfor TPPP2 gene

Localizationfor TPPP2 gene

Pathways & Interactionsfor TPPP2 gene

Drugs & Compoundsfor TPPP2 gene

Transcriptsfor TPPP2 gene

Expression for TPPP2 gene

Orthologsfor TPPP2 gene

Paralogsfor TPPP2 gene

Genomic Variantsfor TPPP2 gene

Disorders / Diseasesfor TPPP2 gene

Publicationsfor TPPP2 gene

External Searches for TPPP2 gene

Genome Databases showing TPPP2 gene

Other Databases showing TPPP2 gene

Specialized Databases showing TPPP2 gene

Intellectual Propertyfor TPPP2 gene

Productsfor TPPP2 gene

View Random Gene

Aliases
for TPPP2 gene

Summaries
for TPPP2 gene

Genomic Views
for TPPP2 gene

Proteins
for TPPP2 gene

Domains /
Families
for TPPP2 gene

Function
for TPPP2 gene

Localization
for TPPP2 gene

Pathways & Interactions
for TPPP2 gene

Drugs & Compounds
for TPPP2 gene

Transcripts
for TPPP2 gene

Expression
for TPPP2 gene

Orthologs
for TPPP2 gene

Paralogs
for TPPP2 gene

Genomic Variants
for TPPP2 gene

Disorders / Diseases
for TPPP2 gene

Publications
for TPPP2 gene

Intellectual Property
for TPPP2 gene

Products
for TPPP2 gene