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TPPP Gene

protein-coding   GIFtS: 61
GCID: GC05M000659

Tubulin Polymerization Promoting Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tubulin Polymerization Promoting Protein1 2     Glycogen Synthase Kinase 3 (GSK3) Inhibitor P242
Brain Specific Protein P25 Alpha1 2     p252
25 KDa Brain-Specific Protein2 3     p25alpha2
TPPP/p252 3     Tubulin Polymerization-Promoting Protein2
TPPP12 3     P245
p242 3     P255
p25-alpha2 3     

External Ids:    HGNC: 241641   Entrez Gene: 110762   Ensembl: ENSG000001713687   OMIM: 6087735   UniProtKB: O948113   

Export aliases for TPPP gene to outside databases

Previous GC identifers: GC05M000713 GC05M000714


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TPPP Gene:
TPPP (tubulin polymerization promoting protein) is a protein-coding gene. Diseases associated with TPPP include lymphoid interstitial pneumonia, and lewy body dementia. GO annotations related to this gene include microtubule binding and tubulin binding. An important paralog of this gene is TPPP3.

UniProtKB/Swiss-Prot: TPPP_HUMAN, O94811
Function: May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the
stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a
role in mitotic spindle assembly and nuclear envelope breakdown

Gene Wiki entry for TPPP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_006576.17  NC_018916.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TPPP
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTPPP promoter sequence
   Search Chromatin IP Primers for TPPP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPPP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.3   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15.33

TPPP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPPP gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M000659:  view genomic region     (about GC identifiers)

Start:
659,977 bp from pter      End:
693,510 bp from pter
Size:
33,534 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TPPP_HUMAN, O94811 (See protein sequence)
Recommended Name: Tubulin polymerization-promoting protein  
Size: 219 amino acids; 23694 Da
Subunit: Homodimer. Binds tubulin; binding is inhibited by GTP (By similarity). Interacts with GSK3 (By
similarity). Interacts with MAPK1 (By similarity). Interacts with GAPDH; the interaction is direct (By
similarity). Interacts with LIMK1 (via the PDZ domain); the interaction is direct
Miscellaneous: Unstructured protein. Interacts with aggregated SNCA and may have a pro-aggregatory role in
synucleinopathies
Sequence caution: Sequence=AAH40496.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for TPPP: NX_O94811

Explore proteomics data for TPPP at MOPED

Post-translational modifications: 

  • Poor substrate for GSK3 (By similarity). Phosphorylated by LIMK1 on serine residues. Phosphorylation may alter the
    tubulin polymerization activity1
  • Glycosylation2 at Ser152
  • Modification sites at PhosphoSitePlus

  • See TPPP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008961.1  
    ENSEMBL proteins: 
     ENSP00000353785  

    TPPP Human Recombinant Protein Products:

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    Novus Biologicals TPPP Protein
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    ProSpec Recombinant Protein for TPPP
    Cloud-Clone Corp. Proteins for TPPP

    TPPP Antibody Products:

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    TPPP Assay Products:

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    Cloud-Clone Corp. ELISAs for TPPP
    Cloud-Clone Corp. CLIAs for TPPP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008907 P25-alpha

    Graphical View of Domain Structure for InterPro Entry O94811

    ProtoNet protein and cluster: O94811

    1 Blocks protein domain: IPB008907 P25-alpha

    UniProtKB/Swiss-Prot: TPPP_HUMAN, O94811
    Similarity: Belongs to the TPPP family


    TPPP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TPPP_HUMAN, O94811
    Function: May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the
    stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a
    role in mitotic spindle assembly and nuclear envelope breakdown

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15590652
    GO:0008017microtubule binding ISS--
    GO:0015631tubulin binding ISS--
         
    TPPP for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Tppp (no phenotypes)

    TPPP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tppptm1(KOMP)Vlcg for TPPP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TPPP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TPPP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TPPP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TPPP

    miRNA
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    miRTarBase miRNAs that target TPPP:
    hsa-mir-34a-5p (MIRT025429), hsa-mir-26b-5p (MIRT029260)

    Block miRNA regulation of human, mouse, rat TPPP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TPPP (see all 47):
    hsa-miR-142-5p hsa-miR-188-5p hsa-miR-106a hsa-miR-199a-3p hsa-miR-25 hsa-miR-3923 hsa-miR-93 hsa-miR-325
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TPPP

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPPP

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPPP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TPPP_HUMAN, O94811: Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Localizes to glial Lewy bodies in the
    brains of individuals with synucleinopathies
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    plasma membrane4
    cytosol2
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18028908
    GO:0005737cytoplasm IDA18028908
    GO:0005874colocalizes with microtubule IDA18028908
    GO:0005886plasma membrane ----
    GO:0005925focal adhesion ----

    TPPP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TPPP About    
    See pathways by source

    SuperPathContained pathways About
    1SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways
    2Regulation of Microtubule Cytoskeleton
    Regulation of Microtubule Cytoskeleton
    3Glial Cell Differentiation
    Glial Cell Differentiation

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TPPP
        Alzheimers Disease Pathway

    3 BioSystems Pathways for TPPP
        SIDS Susceptibility Pathways
    Glial Cell Differentiation
    Regulation of Microtubule Cytoskeleton


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TPPP
    Interactions:

        Search GeneGlobe Interaction Network for TPPP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for TPPP (O948112, 3 ENSP000003537854) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC6A3Q019592, 3, ENSP000002703494MINT-8055798 I2D: score=1 STRING: ENSP00000270349
    SNCAP378402, 3, ENSP000003383454MINT-3387974 I2D: score=1 STRING: ENSP00000338345
    GAPDHP044063, ENSP000002292394I2D: score=1 STRING: ENSP00000229239
    GSK3BP498413, ENSP000003248064I2D: score=1 STRING: ENSP00000324806
    HDAC6Q9UBN73, ENSP000003340614I2D: score=1 STRING: ENSP00000334061
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001578microtubule bundle formation ISS--
    GO:0031334positive regulation of protein complex assembly ISS--
    GO:0032273positive regulation of protein polymerization IDA15590652
    GO:0046785microtubule polymerization ISS--

    TPPP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TPPP

    1 HMDB Compound for TPPP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TPPP gene: 
    NM_007030.2  

    Unigene Cluster for TPPP:

    Tubulin polymerization promoting protein
    Hs.481466  [show with all ESTs]
    Unigene Representative Sequence: NM_007030
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000360578(uc003jbg.4 uc003jbh.4)
    miRNA
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    Block miRNA regulation of human, mouse, rat TPPP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TPPP (see all 47):
    hsa-miR-142-5p hsa-miR-188-5p hsa-miR-106a hsa-miR-199a-3p hsa-miR-25 hsa-miR-3923 hsa-miR-93 hsa-miR-325
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TPPP
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    OriGene ORF clones in mouse, rat for TPPP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TPPP (NM_007030)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TPPP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPPP
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TPPP
      QuantiTect SYBR Green Assays in human, mouse, rat TPPP
      QuantiFast Probe-based Assays in human, mouse, rat TPPP

    Additional mRNA sequence: 

    AB017016.1 AK054920.1 AK098392.1 AY319261.1 BC040496.1 BC131506.1 BC152382.1 BT020035.1 

    5 DOTS entries:

    DT.92011747  DT.417052  DT.97781654  DT.91744550  DT.120853898 

    Selected AceView cDNA sequences (see all 64):

    BQ066916 AA326143 AA325476 NM_007030 BM714107 CK904792 AK098392 AA323815 
    AB017016 BF851670 BM920759 AK054920 AI903155 AA630571 AL120632 BG913777 
    BM694567 BU787419 BQ694905 BX444884 BU787698 AW512005 BM672396 BG055052 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TPPP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGTTCTGA
    TPPP Expression
    About this image


    TPPP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    TPPP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TPPP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.481466

    UniProtKB/Swiss-Prot: TPPP_HUMAN, O94811
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPPP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TPPP gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tppp1 , 5 tubulin polymerization promoting protein1, 5 85.28(n)1
    92.72(a)1
      13 (40.15 cM)5
    729481  NM_182839.21  NP_878259.11 
     740094075 
    chicken
    (Gallus gallus)
    Aves TPPP1 tubulin polymerization promoting protein 69.4(n)
    82.61(a)
      420800  XM_418894.4  XP_418894.1 
    lizard
    (Anolis carolinensis)
    Reptilia TPPP6
    tubulin polymerization promoting protein
    76(a)
    1 ↔ 1
    6(56161991-56209166)
    zebrafish
    (Danio rerio)
    Actinopterygii TPPP6
    tubulin polymerization promoting protein
    61(a)
    1 ↔ 1
    Zv9_scaffold3474(52530-56573) ENSDARG00000067585
    fruit fly
    (Drosophila melanogaster)
    Insecta CG48931 CG4893 55.06(n)
    42.13(a)
      39813  NM_001275010.1  NP_001261939.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C32E8.36
    Protein C32E8.3 (C32E8.3) mRNA, complete cds
    36(a)
    1 → many
    I(3786594-3787495) WBGene00016321


    ENSEMBL Gene Tree for TPPP (if available)
    TreeFam Gene Tree for TPPP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TPPP gene
    TPPP32  TPPP22  
    3 SIMAP similar genes for TPPP using alignment to 1 protein entry:     TPPP_HUMAN:
    FREP1    TPPP3    TPPP2

    TPPP for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TPPP
    PGOHUM00000235108


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TPPP (see all 1081)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38403091,2
    C--647104(+) CTGAG-/TC    
       CCCTG
    GCCTC
    1 -- int10--------
    rs16896711,2
    C,F,A,H--659605(+) GTTTCG/ACTGGG 1 -- int124Minor allele frequency- A:0.21NS EA NA CSA WA 2768
    rs582233391,2
    C--659679(+) GTGGT-/TGGT  
            
    GTTCA
    1 -- int10--------
    rs1487726941,2
    --659687(+) GTGTTC/TACAGT 1 -- int10--------
    rs16979621,2
    C,A,H--659690(+) TTCACA/GGTGTT 1 -- int110Minor allele frequency- G:0.37MN EA WA NA CSA 729
    rs715976611,2
    C,F--659751(+) AGAGCG/AGGACT 1 -- int12Minor allele frequency- A:0.25NA 4
    rs1447888071,2
    --659781(+) GTCCGC/TCTGCT 1 -- int10--------
    rs1479091641,2
    --659796(+) CTTCAC/TGGTCC 1 -- int10--------
    rs1144293481,2
    F--660031(+) GTTAAC/TGACAG 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs1874521891,2
    --660169(+) ACCCCA/GCGGAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TPPP (659977 - 693510 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TPPP (see all 73):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2259846CNV Deletion18987734
    dgv955e201CNV Deletion23290073
    esv2729351CNV Deletion23290073
    esv2729359CNV Deletion23290073
    esv2675669CNV Deletion23128226
    esv1335572CNV Deletion17803354
    dgv1000e199CNV Deletion23128226
    esv2729353CNV Deletion23290073
    esv2729358CNV Deletion23290073
    esv2729355CNV Deletion23290073

    Human Gene Mutation Database (HGMD): TPPP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TPPP
    DNA2.0 Custom Variant and Variant Library Synthesis for TPPP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608773    OMIM disorders: --

    14 diseases for TPPP:    
    About MalaCards
    lymphoid interstitial pneumonia    lewy body dementia    multiple system atrophy    pneumonia
    dementia    multiple myeloma    myeloma    multiple sclerosis
    ulcerative colitis    cerebritis    alzheimer's disease    neuroblastoma
    malaria    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for TPPP:
    Multiple system atrophy     Lewy body dementia

    TPPP for disorders           About GeneDecksing

    Genetic Association Database (GAD): TPPP

    Export disorders for TPPP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TPPP gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with TPPP)
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    1. Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. (PubMed id 17105200)1, 2, 3 Vincze O....Ovadi J. (Biochemistry 2006)
    2. p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. (PubMed id 15590652)1, 2, 3 Lindersson E.... Jensen P.H. (J. Biol. Chem. 2005)
    3. A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3. (PubMed id 10083737)1, 2, 3 Seki N.... Saito T. (J. Hum. Genet. 1999)
    4. Phosphorylation blocks the activity of tubulin polymerization- promoting protein (TPPP): identification of sites targeted by different kinases. (PubMed id 17693641)1, 2, 9 Hlavanda E.... Ovadi J. (J. Biol. Chem. 2007)
    5. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PubMed id 20228799)1, 4 McGovern D.P....Seielstad M. (Nat. Genet. 2010)
    6. The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules. (PubMed id 18028908)1, 2 Acevedo K.... Bernard O. (Exp. Cell Res. 2007)
    7. Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies. (PubMed id 17027006)1, 2 Olah J.... Ovadi J. (FEBS Lett. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations. (PubMed id 12093283)1, 3 Hlavanda E....OvA!di J. (Biochemistry 2002)
    10. p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy. (PubMed id 17823288)1, 9 Song Y.J....Jensen P.H. (Am. J. Pathol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11076 HGNC: 24164 AceView: TPPP Ensembl:ENSG00000171368 euGenes: HUgn11076
    ECgene: TPPP H-InvDB: TPPP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TPPP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TPPP gene:
    Search GeneIP for patents involving TPPP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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