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Aliases for TPPP Gene

Aliases for TPPP Gene

  • Tubulin Polymerization Promoting Protein 2 3
  • P24 3 4 6
  • Brain Specific Protein P25 Alpha 2 3
  • 25 KDa Brain-Specific Protein 3 4
  • P25-Alpha 3 4
  • TPPP/P25 3 4
  • TPPP1 3 4
  • P25 3 6
  • Glycogen Synthase Kinase 3 (GSK3) Inhibitor P24 3
  • Tubulin Polymerization-Promoting Protein 3
  • P25alpha 3

External Ids for TPPP Gene

Previous GeneCards Identifiers for TPPP Gene

  • GC05M000713
  • GC05M000714

Summaries for TPPP Gene

GeneCards Summary for TPPP Gene

TPPP (Tubulin Polymerization Promoting Protein) is a Protein Coding gene. Among its related pathways are Alzheimers Disease Pathway and SIDS Susceptibility Pathways. GO annotations related to this gene include microtubule binding and tubulin binding. An important paralog of this gene is TPPP3.

UniProtKB/Swiss-Prot for TPPP Gene

  • May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.

Gene Wiki entry for TPPP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPPP Gene

Genomics for TPPP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TPPP Gene

Start:
659,862 bp from pter
End:
693,395 bp from pter
Size:
33,534 bases
Orientation:
Minus strand

Genomic View for TPPP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPPP Gene

No data available for Regulatory Elements for TPPP Gene

Proteins for TPPP Gene

  • Protein details for TPPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94811-TPPP_HUMAN
    Recommended name:
    Tubulin polymerization-promoting protein
    Protein Accession:
    O94811
    Secondary Accessions:

    Protein attributes for TPPP Gene

    Size:
    219 amino acids
    Molecular mass:
    23694 Da
    Quaternary structure:
    • Homodimer. Binds tubulin; binding is inhibited by GTP (By similarity). Interacts with GSK3 (By similarity). Interacts with MAPK1 (By similarity). Interacts with GAPDH; the interaction is direct (By similarity). Interacts with LIMK1 (via the PDZ domain); the interaction is direct.
    Miscellaneous:
    • Unstructured protein. Interacts with aggregated SNCA and may have a pro-aggregatory role in synucleinopathies
    SequenceCaution:
    • Sequence=AAH40496.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TPPP Gene

Proteomics data for TPPP Gene at MOPED

Post-translational modifications for TPPP Gene

  • Poor substrate for GSK3 (By similarity). Phosphorylated by LIMK1 on serine residues. Phosphorylation may alter the tubulin polymerization activity.
  • Glycosylation at Ser152
  • Modification sites at PhosphoSitePlus

Other Protein References for TPPP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TPPP Gene

Domains for TPPP Gene

Protein Domains for TPPP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TPPP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94811

UniProtKB/Swiss-Prot:

TPPP_HUMAN :
  • O94811
Family:
  • Belongs to the TPPP family.
genes like me logo Genes that share domains with TPPP: view

No data available for Gene Families for TPPP Gene

Function for TPPP Gene

Molecular function for TPPP Gene

UniProtKB/Swiss-Prot Function: May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.

Gene Ontology (GO) - Molecular Function for TPPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15590652
GO:0008017 microtubule binding ISS --
GO:0015631 tubulin binding ISS --
genes like me logo Genes that share ontologies with TPPP: view

Animal Model Products

CRISPR Products

miRNA for TPPP Gene

miRTarBase miRNAs that target TPPP

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPPP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TPPP Gene

Localization for TPPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPPP Gene

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPPP Gene COMPARTMENTS Subcellular localization image for TPPP gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 4
cytosol 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TPPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18028908
GO:0005737 cytoplasm IDA 18028908
GO:0005874 colocalizes_with microtubule IDA 18028908
GO:0048471 perinuclear region of cytoplasm IDA 15590652
genes like me logo Genes that share ontologies with TPPP: view

Pathways for TPPP Gene

genes like me logo Genes that share pathways with TPPP: view

Pathways by source for TPPP Gene

Gene Ontology (GO) - Biological Process for TPPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation ISS --
GO:0031334 positive regulation of protein complex assembly ISS --
GO:0032273 positive regulation of protein polymerization IDA 15590652
GO:0046785 microtubule polymerization ISS --
genes like me logo Genes that share ontologies with TPPP: view

Compounds for TPPP Gene

(1) HMDB Compounds for TPPP Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with TPPP: view

Transcripts for TPPP Gene

mRNA/cDNA for TPPP Gene

Unigene Clusters for TPPP Gene

Tubulin polymerization promoting protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPPP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPPP Gene

No ASD Table

Relevant External Links for TPPP Gene

GeneLoc Exon Structure for
TPPP
ECgene alternative splicing isoforms for
TPPP

Expression for TPPP Gene

mRNA expression in normal human tissues for TPPP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TPPP Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (5.2), Brain - Anterior cingulate cortex (BA24) (4.5), Brain - Cortex (4.5), Brain - Hippocampus (4.4), and Brain - Spinal cord (cervical c-1) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPPP Gene

SOURCE GeneReport for Unigene cluster for TPPP Gene Hs.481466

mRNA Expression by UniProt/SwissProt for TPPP Gene

O94811-TPPP_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with TPPP: view

In Situ Assay Products

Orthologs for TPPP Gene

This gene was present in the common ancestor of animals.

Orthologs for TPPP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPPP 35
  • 98.33 (n)
  • 98.63 (a)
TPPP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TPPP 35
  • 86.79 (n)
  • 89.86 (a)
TPPP 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPPP 35
  • 90.13 (n)
  • 95.15 (a)
TPPP 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tppp 35
  • 85.28 (n)
  • 92.72 (a)
Tppp 16
Tppp 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TPPP 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TPPP 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tppp 35
  • 86.89 (n)
  • 93.2 (a)
chicken
(Gallus gallus)
Aves TPPP 35
  • 69.4 (n)
  • 82.61 (a)
TPPP 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TPPP 36
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TPPP 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006948 35
  • 50.81 (n)
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4893 35
  • 55.06 (n)
  • 42.13 (a)
CG4893 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C32E8.3 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToMany
Species with no ortholog for TPPP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TPPP Gene

ENSEMBL:
Gene Tree for TPPP (if available)
TreeFam:
Gene Tree for TPPP (if available)

Paralogs for TPPP Gene

Paralogs for TPPP Gene

Selected SIMAP similar genes for TPPP Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TPPP Gene

genes like me logo Genes that share paralogs with TPPP: view

Variants for TPPP Gene

Sequence variations from dbSNP and Humsavar for TPPP Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs7433 -- 660,661(+) AAGGC(A/G/T)TCTCC utr-variant-3-prime, downstream-variant-500B
rs7434 -- 660,689(+) CTCCA(C/G/T)TTGTA utr-variant-3-prime, downstream-variant-500B
rs7558 -- 660,376(+) CATCT(C/T)GATGT utr-variant-3-prime
rs11194 -- 660,575(-) CCCTC(C/T)CACCC utr-variant-3-prime, downstream-variant-500B
rs364147 -- 694,290(+) GACTT(C/G)AGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TPPP Gene

Variant ID Type Subtype PubMed ID
esv2752071 CNV Gain 17911159
nsv880710 CNV Loss 21882294
dgv5883n71 CNV Gain 21882294
dgv5884n71 CNV Gain 21882294
nsv881305 CNV Loss 21882294
nsv509042 CNV Insertion 20534489
nsv881103 CNV Gain 21882294
dgv5893n71 CNV Gain 21882294
nsv510933 CNV Complex 20534489
nsv461894 CNV Gain 19166990
nsv525620 CNV Gain 19592680
dgv5n29 CNV Gain 16826518
nsv471627 CNV Gain+Loss 15918152
dgv1735e1 CNV Complex 17122850
dgv1736e1 CNV Complex 17122850
nsv428459 CNV Gain+Loss 18775914
nsv881247 CNV Gain 21882294
essv13335 CNV CNV 17122850
dgv1737e1 CNV Complex 17122850
nsv822929 CNV Loss 20364138
dgv5894n71 CNV Gain+Loss 21882294
nsv4675 CNV Loss 18451855
dgv195e55 CNV Gain 17911159
dgv922n67 CNV Gain 20364138
nsv880586 CNV Gain 21882294
nsv329077 CNV Loss 16902084
esv2729349 CNV Deletion 23290073
nsv329408 CNV Loss 16902084
nsv819793 CNV Gain 19587683
nsv881104 CNV Loss 21882294
esv24225 CNV Gain+Loss 19812545
esv2439668 CNV Deletion 19546169
esv2729351 CNV Deletion 23290073
esv2259846 CNV Deletion 18987734
nsv328023 CNV Loss 16902084
esv988665 CNV Loss 20482838
dgv955e201 CNV Deletion 23290073
esv1611660 CNV Deletion 17803354
esv2729353 CNV Deletion 23290073
esv2729355 CNV Deletion 23290073
esv993461 CNV Deletion 20482838
esv1432368 CNV Deletion 17803354
esv1335572 CNV Deletion 17803354
esv2729357 CNV Deletion 23290073
nsv519836 CNV Loss 19592680
nsv818307 CNV Loss 17921354
dgv5895n71 CNV Gain 21882294
esv2675669 CNV Deletion 23128226
esv33266 CNV Gain+Loss 17666407
nsv10654 CNV Gain+Loss 18304495
esv2729358 CNV Deletion 23290073
esv2729359 CNV Deletion 23290073
dgv1738e1 CNV Complex 17122850
dgv1739e1 CNV Complex 17122850
dgv1740e1 CNV Complex 17122850
nsv329251 CNV Insertion 16902084
dgv1000e199 CNV Deletion 23128226
nsv4677 CNV Insertion 18451855
dgv99e19 CNV Loss 19470904
dgv196e55 CNV Gain 17911159
dgv197e55 CNV Gain 17911159
dgv198e55 CNV Gain 17911159
dgv5896n71 CNV Gain+Loss 21882294
dgv5897n71 CNV Gain 21882294
nsv881456 CNV Gain+Loss 21882294
dgv5898n71 CNV Gain 21882294
nsv822931 CNV Gain 20364138
dgv923n67 CNV Gain 20364138
nsv822939 CNV Gain 20364138
dgv18n31 CNV Duplication 19718026
nsv436080 CNV Insertion 17901297
esv1005452 CNV Loss 20482838
esv29941 CNV Loss 18421352

Relevant External Links for TPPP Gene

HapMap Linkage Disequilibrium report
TPPP
Human Gene Mutation Database (HGMD)
TPPP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPPP Gene

Disorders for TPPP Gene

(2) University of Copenhagen DISEASES for TPPP Gene

Relevant External Links for TPPP

Genetic Association Database (GAD)
TPPP
genes like me logo Genes that share disorders with TPPP: view

No data available for UniProtKB/Swiss-Prot for TPPP Gene

Publications for TPPP Gene

  1. Phosphorylation blocks the activity of tubulin polymerization- promoting protein (TPPP): identification of sites targeted by different kinases. (PMID: 17693641) Hlavanda E. … Ovadi J. (J. Biol. Chem. 2007) 3 4 23
  2. Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. (PMID: 17105200) Vincze O. … Ovadi J. (Biochemistry 2006) 2 3 4
  3. A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3. (PMID: 10083737) Seki N. … Saito T. (J. Hum. Genet. 1999) 2 3 4
  4. p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. (PMID: 15590652) Lindersson E. … Jensen P.H. (J. Biol. Chem. 2005) 2 3 4
  5. Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies. (PMID: 17027006) Olah J. … Ovadi J. (FEBS Lett. 2006) 3 4

Products for TPPP Gene

Sources for TPPP Gene

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