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Aliases for TPPP Gene

Aliases for TPPP Gene

  • Tubulin Polymerization Promoting Protein 2 3 5
  • Brain Specific Protein P25 Alpha 2 3
  • 25 KDa Brain-Specific Protein 3 4
  • P25-Alpha 3 4
  • TPPP/P25 3 4
  • TPPP1 3 4
  • P24 3 4
  • Glycogen Synthase Kinase 3 (GSK3) Inhibitor P24 3
  • P25alpha 3
  • P25 3

External Ids for TPPP Gene

Previous GeneCards Identifiers for TPPP Gene

  • GC05M000713
  • GC05M000714

Summaries for TPPP Gene

GeneCards Summary for TPPP Gene

TPPP (Tubulin Polymerization Promoting Protein) is a Protein Coding gene. Diseases associated with TPPP include Lymphoid Interstitial Pneumonia and Dementia, Lewy Body. Among its related pathways are Regulation of Microtubule Cytoskeleton and SIDS Susceptibility Pathways. GO annotations related to this gene include microtubule binding and tubulin binding. An important paralog of this gene is TPPP3.

UniProtKB/Swiss-Prot for TPPP Gene

  • May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.

Gene Wiki entry for TPPP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPPP Gene

Genomics for TPPP Gene

Regulatory Elements for TPPP Gene

Enhancers for TPPP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TPPP on UCSC Golden Path with GeneCards custom track

Promoters for TPPP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TPPP on UCSC Golden Path with GeneCards custom track

Genomic Location for TPPP Gene

659,862 bp from pter
693,395 bp from pter
33,534 bases
Minus strand

Genomic View for TPPP Gene

Genes around TPPP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPPP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPPP Gene

Proteins for TPPP Gene

  • Protein details for TPPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tubulin polymerization-promoting protein
    Protein Accession:

    Protein attributes for TPPP Gene

    219 amino acids
    Molecular mass:
    23694 Da
    Quaternary structure:
    • Homodimer. Binds tubulin; binding is inhibited by GTP (By similarity). Interacts with GSK3 (By similarity). Interacts with MAPK1 (By similarity). Interacts with GAPDH; the interaction is direct (By similarity). Interacts with LIMK1 (via the PDZ domain); the interaction is direct.
    • Unstructured protein. Interacts with aggregated SNCA and may have a pro-aggregatory role in synucleinopathies.
    • Sequence=AAH40496.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TPPP Gene

Proteomics data for TPPP Gene at MOPED

Post-translational modifications for TPPP Gene

  • Poor substrate for GSK3 (By similarity). Phosphorylated by LIMK1 on serine residues. Phosphorylation may alter the tubulin polymerization activity.
  • Glycosylation at Ser 152
  • Modification sites at PhosphoSitePlus

Other Protein References for TPPP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TPPP Gene

Domains & Families for TPPP Gene

Gene Families for TPPP Gene

Protein Domains for TPPP Gene


Suggested Antigen Peptide Sequences for TPPP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TPPP family.
  • Belongs to the TPPP family.
genes like me logo Genes that share domains with TPPP: view

Function for TPPP Gene

Molecular function for TPPP Gene

UniProtKB/Swiss-Prot Function:
May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.

Gene Ontology (GO) - Molecular Function for TPPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015631 tubulin binding ISS --
genes like me logo Genes that share ontologies with TPPP: view
genes like me logo Genes that share phenotypes with TPPP: view

Animal Models for TPPP Gene

MGI Knock Outs for TPPP:
  • Tppp tm1.1(KOMP)Vlcg

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TPPP Gene

Localization for TPPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPPP Gene

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies.

Subcellular locations from

Jensen Localization Image for TPPP Gene COMPARTMENTS Subcellular localization image for TPPP gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for TPPP Gene

Pathways & Interactions for TPPP Gene

genes like me logo Genes that share pathways with TPPP: view

Pathways by source for TPPP Gene

Gene Ontology (GO) - Biological Process for TPPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation ISS --
GO:0031334 positive regulation of protein complex assembly ISS --
genes like me logo Genes that share ontologies with TPPP: view

No data available for SIGNOR curated interactions for TPPP Gene

Drugs & Compounds for TPPP Gene

(2) Drugs for TPPP Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
BNC105P Pharma inhibitor microtubule polymerization inhibitor, Vascular disrupting agents (VDA) 0
genes like me logo Genes that share compounds with TPPP: view

Transcripts for TPPP Gene

mRNA/cDNA for TPPP Gene

Unigene Clusters for TPPP Gene

Tubulin polymerization promoting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPPP Gene

No ASD Table

Relevant External Links for TPPP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPPP Gene

mRNA expression in normal human tissues for TPPP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TPPP Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.2), Brain - Anterior cingulate cortex (BA24) (x4.5), Brain - Cortex (x4.5), Brain - Hippocampus (x4.4), and Brain - Spinal cord (cervical c-1) (x4.0).

Protein differential expression in normal tissues from HIPED for TPPP Gene

This gene is overexpressed in Brain (32.7) and Frontal cortex (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPPP Gene

SOURCE GeneReport for Unigene cluster for TPPP Gene Hs.481466

mRNA Expression by UniProt/SwissProt for TPPP Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with TPPP: view

Protein tissue co-expression partners for TPPP Gene

- Elite partner

Primer Products

Orthologs for TPPP Gene

This gene was present in the common ancestor of animals.

Orthologs for TPPP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TPPP 35
  • 86.79 (n)
  • 89.86 (a)
  • 88 (a)
(Canis familiaris)
Mammalia TPPP 35
  • 90.13 (n)
  • 95.15 (a)
  • 91 (a)
(Mus musculus)
Mammalia Tppp 35
  • 85.28 (n)
  • 92.72 (a)
Tppp 16
Tppp 36
  • 91 (a)
(Pan troglodytes)
Mammalia TPPP 35
  • 98.33 (n)
  • 98.63 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Tppp 35
  • 86.89 (n)
  • 93.2 (a)
(Monodelphis domestica)
Mammalia TPPP 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia TPPP 36
  • 69 (a)
(Gallus gallus)
Aves TPPP 35
  • 69.4 (n)
  • 82.61 (a)
  • 80 (a)
(Anolis carolinensis)
Reptilia TPPP 36
  • 76 (a)
(Danio rerio)
Actinopterygii TPPP 36
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006948 35
  • 50.81 (n)
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4893 35
  • 55.06 (n)
  • 42.13 (a)
CG4893 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea C32E8.3 36
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
Species with no ortholog for TPPP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TPPP Gene

Gene Tree for TPPP (if available)
Gene Tree for TPPP (if available)

Paralogs for TPPP Gene

Paralogs for TPPP Gene

(3) SIMAP similar genes for TPPP Gene using alignment to 1 proteins: Pseudogenes for TPPP Gene

genes like me logo Genes that share paralogs with TPPP: view

Variants for TPPP Gene

Sequence variations from dbSNP and Humsavar for TPPP Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2640656 -- 674,665(+) GCAGC(A/T)GGCTG intron-variant
rs2640657 -- 679,862(+) AGGAC(G/T)TCCCA intron-variant
rs903074 -- 688,399(+) GCACA(C/G)TATTG intron-variant
rs2652414 -- 679,870(+) CCAGC(C/T)CATCA intron-variant
rs1108702 -- 691,486(+) CTGCA(A/C)GCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPPP Gene

Variant ID Type Subtype PubMed ID
esv2752071 CNV Gain 17911159
nsv880710 CNV Loss 21882294
dgv5883n71 CNV Gain 21882294
dgv5884n71 CNV Gain 21882294
nsv881305 CNV Loss 21882294
nsv509042 CNV Insertion 20534489
nsv881103 CNV Gain 21882294
dgv5893n71 CNV Gain 21882294
nsv510933 CNV Complex 20534489
nsv461894 CNV Gain 19166990
nsv525620 CNV Gain 19592680
dgv5n29 CNV Gain 16826518
nsv471627 CNV Gain+Loss 15918152
dgv1735e1 CNV Complex 17122850
dgv1736e1 CNV Complex 17122850
nsv428459 CNV Gain+Loss 18775914
nsv881247 CNV Gain 21882294
essv13335 CNV CNV 17122850
dgv1737e1 CNV Complex 17122850
nsv822929 CNV Loss 20364138
dgv5894n71 CNV Gain+Loss 21882294
nsv4675 CNV Loss 18451855
dgv195e55 CNV Gain 17911159
dgv922n67 CNV Gain 20364138
nsv880586 CNV Gain 21882294
nsv329077 CNV Loss 16902084
esv2729349 CNV Deletion 23290073
nsv329408 CNV Loss 16902084
nsv819793 CNV Gain 19587683
nsv881104 CNV Loss 21882294
esv24225 CNV Gain+Loss 19812545
esv2439668 CNV Deletion 19546169
esv2729351 CNV Deletion 23290073
esv2259846 CNV Deletion 18987734
nsv328023 CNV Loss 16902084
esv988665 CNV Loss 20482838
dgv955e201 CNV Deletion 23290073
esv1611660 CNV Deletion 17803354
esv2729353 CNV Deletion 23290073
esv2729355 CNV Deletion 23290073
esv993461 CNV Deletion 20482838
esv1432368 CNV Deletion 17803354
esv1335572 CNV Deletion 17803354
esv2729357 CNV Deletion 23290073
nsv519836 CNV Loss 19592680
nsv818307 CNV Loss 17921354
dgv5895n71 CNV Gain 21882294
esv2675669 CNV Deletion 23128226
esv33266 CNV Gain+Loss 17666407
nsv10654 CNV Gain+Loss 18304495
esv2729358 CNV Deletion 23290073
esv2729359 CNV Deletion 23290073
dgv1738e1 CNV Complex 17122850
dgv1739e1 CNV Complex 17122850
dgv1740e1 CNV Complex 17122850
nsv329251 CNV Insertion 16902084
dgv1000e199 CNV Deletion 23128226
nsv4677 CNV Insertion 18451855
dgv99e19 CNV Loss 19470904
dgv196e55 CNV Gain 17911159
dgv197e55 CNV Gain 17911159
dgv198e55 CNV Gain 17911159
dgv5896n71 CNV Gain+Loss 21882294
dgv5897n71 CNV Gain 21882294
nsv881456 CNV Gain+Loss 21882294
dgv5898n71 CNV Gain 21882294
nsv822931 CNV Gain 20364138
dgv923n67 CNV Gain 20364138
nsv822939 CNV Gain 20364138
dgv18n31 CNV Duplication 19718026
nsv436080 CNV Insertion 17901297
esv1005452 CNV Loss 20482838
esv29941 CNV Loss 18421352

Variation tolerance for TPPP Gene

Residual Variation Intolerance Score: 31.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPPP Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPPP Gene

Disorders for TPPP Gene

MalaCards: The human disease database

(2) MalaCards diseases for TPPP Gene - From: DISEASES

Disorder Aliases PubMed IDs
lymphoid interstitial pneumonia
  • lymphocytic interstitial pneumonia
dementia, lewy body
  • lewy body dementia
- elite association - COSMIC cancer census association via MalaCards
Search TPPP in MalaCards View complete list of genes associated with diseases

Relevant External Links for TPPP

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TPPP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPPP Gene

Publications for TPPP Gene

  1. Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. (PMID: 17105200) Vincze O. … Ovadi J. (Biochemistry 2006) 2 3 4 67
  2. Phosphorylation blocks the activity of tubulin polymerization- promoting protein (TPPP): identification of sites targeted by different kinases. (PMID: 17693641) Hlavanda E. … Ovadi J. (J. Biol. Chem. 2007) 3 23
  3. p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy. (PMID: 17823288) Song Y.J. … Jensen P.H. (Am. J. Pathol. 2007) 3 23
  4. Gain of 5p15.33 is associated with progression of bladder cancer. (PMID: 18025801) Yamamoto Y. … Sasaki K. (Oncology 2007) 3 23
  5. p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. (PMID: 15590652) Lindersson E. … Jensen P.H. (J. Biol. Chem. 2005) 2 3

Products for TPPP Gene

Sources for TPPP Gene