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TPP2 Gene

protein-coding   GIFtS: 61
GCID: GC13P103249

Tripeptidyl Peptidase II

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripeptidyl Peptidase II1 2     TPP-II2 3
Tripeptidyl Aminopeptidase2 3     EC 3.4.14.103 8
Tripeptidyl-Peptidase II2 3     Tripeptidyl-Peptidase 22
TPP-22 3     

External Ids:    HGNC: 120161   Entrez Gene: 71742   Ensembl: ENSG000001349007   OMIM: 1904705   UniProtKB: P291443   

Export aliases for TPP2 gene to outside databases

Previous GC identifers: GC13P101609 GC13P097636 GC13P102086 GC13P100947 GC13P102047 GC13P083841


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TPP2 Gene:
This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer
peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The
protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at
the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. (provided by
RefSeq, Jul 2008)

GeneCards Summary for TPP2 Gene:
TPP2 (tripeptidyl peptidase II) is a protein-coding gene. GO annotations related to this gene include endopeptidase activity and serine-type endopeptidase activity.

UniProtKB/Swiss-Prot: TPP2_HUMAN, P29144
Function: Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome
pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the
latter is inhibited (By similarity)

Gene Wiki entry for TPP2 (Tripeptidyl peptidase II) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_009952.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TPP2 gene promoter:
         AhR   Pax-6   AP-2gamma   c-Ets-1   Evi-1   NRF-2   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTPP2 promoter sequence
   Search Chromatin IP Primers for TPP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32-q33   Ensembl cytogenetic band:  13q33.1   HGNC cytogenetic band: 13q32-q33

TPP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPP2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P103249:  view genomic region     (about GC identifiers)

Start:
103,249,286 bp from pter      End:
103,331,524 bp from pter
Size:
82,239 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TPP2_HUMAN, P29144 (See protein sequence)
Recommended Name: Tripeptidyl-peptidase 2  
Size: 1249 amino acids; 138350 Da
Miscellaneous: The limitation of proteolytic products to tripeptides is achieved by tailoring the size of the
substrate-binding cleft: the two negatively charged residues Glu-305 and Glu-331 that are blocking position P4
limit the number of residues that can be accommodated in the binding cleft and thus create a molecular ruler. At
the same time, they orient substrates so that the tripeptides are removed exclusively from the N-terminus (By
similarity)
Secondary accessions: Q5VZU8

Explore the universe of human proteins at neXtProt for TPP2: NX_P29144

Explore proteomics data for TPP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys19, Lys1005, Lys1013, Lys1180, Lys1187
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TPP2 (P29144) (see all 11)
     KLVEEKP  QLMNGTSM  VSSAGNNGP  APGGAIASVP 


    See TPP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003282.2  
    ENSEMBL proteins: 
     ENSP00000365233   ENSP00000365220  
    Reactome Protein details: P29144

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR000209 Peptidase_S8/S53_dom
     IPR015500 Peptidase_S8_subtilisin-rel
     IPR022398 Peptidase_S8_His-AS
     IPR023828 Peptidase_S8_Ser-AS
     IPR022229 Peptidase_S8A_TPPII

    Graphical View of Domain Structure for InterPro Entry P29144

    ProtoNet protein and cluster: P29144

    1 Blocks protein domain: IPB000209 Subtilisin serine protease family (S8) signature

    UniProtKB/Swiss-Prot: TPP2_HUMAN, P29144
    Similarity: Belongs to the peptidase S8 family


    Find genes that share domains with TPP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TPP2_HUMAN, P29144
    Function: Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome
    pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the
    latter is inhibited (By similarity)
    Catalytic activity: Release of an N-terminal tripeptide from a polypeptide

         Genatlas biochemistry entry for TPP2:
    tripeptidyl peptidase 2

         Enzyme Number (IUBMB): EC 3.4.14.101 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004175endopeptidase activity TAS9974389
    GO:0004177aminopeptidase activity IEA--
    GO:0004252serine-type endopeptidase activity IBA--
    GO:0008240tripeptidyl-peptidase activity TAS9974389
         
    Find genes that share ontologies with TPP2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TPP2:
     Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tpp2):
     cellular  growth/size/body  hematopoietic system  immune system  integument 
     mortality/aging  no phenotypic analysis 

    Find genes that share phenotypes with TPP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tpp2tm1.1Gnie for TPP2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TPP2
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    miRNA
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    hsa-mir-155-5p (MIRT020939), hsa-let-7b-5p (MIRT032480)

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    8 qRT-PCR Assays for microRNAs that regulate TPP2:
    hsa-miR-3142 hsa-miR-3163 hsa-miR-205 hsa-miR-16-2* hsa-miR-586 hsa-miR-195* hsa-miR-485-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidTPP2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TPP2_HUMAN, P29144: Cytoplasm. Nucleus. Note=Translocates to the nucleus in responce to gamma-irradiation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS9974389
    GO:0005829cytosol TAS--

    Find genes that share ontologies with TPP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TPP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84


    Find genes that share SuperPaths with TPP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for TPP2
        Antigen processing: Ubiquitination & Proteasome degradation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TPP2
    Interactions:

        Search GeneGlobe Interaction Network for TPP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TPP2 (P291443 ENSP000003652334) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-BP304803, ENSP000003991684I2D: score=1 STRING: ENSP00000399168
    MCCP235083, ENSP000003862274I2D: score=1 STRING: ENSP00000386227
    ARHGAP17Q68EM73I2D: score=5 
    MED28Q9H2043I2D: score=5 
    SLC2A4P146723I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0006508proteolysis IBA--

    Find genes that share ontologies with TPP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TPP2

    3 Novoseek inferred chemical compound relationships for TPP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ala-ala-phe-chloromethyl ketone 94.3 7 11374791 (1), 18286573 (1), 11149939 (1)
    tripeptide s 75.8 5 18822395 (1), 9668104 (1), 19198062 (1)
    serine 50.1 16 15907785 (2), 7998988 (1), 1670990 (1), 14643348 (1) (see all 10)



    Find genes that share compounds with TPP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TPP2 gene: 
    NM_003291.2  

    Unigene Cluster for TPP2:

    Tripeptidyl peptidase II
    Hs.432424  [show with all ESTs]
    Unigene Representative Sequence: NM_003291
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376065 ENST00000376052(uc001vpi.4) ENST00000490010 ENST00000496126
    ENST00000493770 ENST00000490420 ENST00000466153 ENST00000482393
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate TPP2:
    hsa-miR-3142 hsa-miR-3163 hsa-miR-205 hsa-miR-16-2* hsa-miR-586 hsa-miR-195* hsa-miR-485-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidTPP2 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TPP2
      QuantiFast Probe-based Assays in human, mouse, rat TPP2

    Additional mRNA sequence: 

    AK097678.1 AK127549.1 AK304313.1 BC024905.1 BC039905.1 M55169.1 M73047.1 

    19 DOTS entries:

    DT.445238  DT.97812362  DT.100035665  DT.99998758  DT.97842940  DT.92436957  DT.86854081  DT.120778938 
    DT.86851534  DT.91691261  DT.99993433  DT.100672767  DT.116277  DT.120778932  DT.91855350  DT.100643103 
    DT.40261432  DT.86846420  DT.91852416 

    Selected AceView cDNA sequences (see all 234):

    AW468038 BX382744 AA251296 CB158047 AA234593 M73047 AL044959 AA612917 
    BM836665 AI281385 AI273158 BM839394 BM710921 AI089861 BC024905 AA460009 
    AL042005 M55169 AL045733 NM_003291 BP368875 CA311001 BQ694372 BX643604 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TPP2 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a ·
    SP1:                                                                                                                                            -           -   
    SP2:                    -                                                                                                                                       
    SP3:                                                                                      -                                                                     
    SP4:                                                                                      -                                                                     
    SP5:                                                                                      -                 -                                                   

    ExUns: 21b ^ 22a · 22b · 22c ^ 23a · 23b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for TPP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TPP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAATTTG
    TPP2 Expression
    About this image


    TPP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    TPP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TPP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.432424
        Custom PCR Arrays for TPP2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TPP2 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tpp21 , 5 tripeptidyl peptidase II1, 5 90.37(n)1
    96.32(a)1
      1 (23.50 cM)5
    220191  NM_009418.21  NP_033444.11 
     439340075 
    chicken
    (Gallus gallus)
    Aves TPP21 tripeptidyl peptidase II 81.33(n)
    86.12(a)
      428020  XM_004938558.1  XP_004938615.1 
    lizard
    (Anolis carolinensis)
    Reptilia TPP26
    tripeptidyl peptidase II
    83(a)
    1 ↔ 1
    3(100882194-100941172)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.207202 Xenopus laevis transcribed sequence with moderate similarity more 73.85(n)    BU913267.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tpp21 tripeptidyl peptidase II 66.27(n)
    75.08(a)
      100331669  XM_005168011.1  XP_005168068.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TppII1 , 3 tripeptidyl-peptidase II1, 3 40(a)3
    48.47(n)1
    41.24(a)1
      49F43
    364441  NM_165966.11  NP_725252.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F21H12.61 , 3 Tripeptidyl-peptidase II3
    F21H12.61
    37(a)3
    48.61(n)1
    38.15(a)1
      II(6092836-6097387)3
    1740181  NM_062820.31  NP_495221.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TPP21 TPP2 49.78(n)
    40.51(a)
      827833  NM_118203.3  NP_193817.2 
    rice
    (Oryza sativa)
    Liliopsida Os.279502 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.18(n)    AK067099.1 


    ENSEMBL Gene Tree for TPP2 (if available)
    TreeFam Gene Tree for TPP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TPP2 (see all 1821)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58063151,2
    C--84218611(+) ttttt-/TTTgagac 1 -- int1 trp31Minor allele frequency- TTT:0.00NA 2
    rs1904759431,2
    --103247451(+) TACTCA/TGGCAA 1 -- us2k10--------
    rs1831781071,2
    --103247512(+) CAAATA/CCCGTG 1 -- us2k10--------
    rs175068751,2
    C,F,H--103247514(+) AATCCC/AGTGTT 1 -- us2k128Minor allele frequency- A:0.07NA NS EA WA 3048
    rs47724911,2
    C,F,A,H--103247603(+) GTTCAT/CTTGAA 1 -- us2k1 tfbs334Minor allele frequency- C:0.28NA NS EA WA CSA 3335
    rs47724921,2
    C,F,A,H--103247624(+) ATTCTA/GTTCTA 1 -- us2k132Minor allele frequency- G:0.30NA NS EA WA CSA 2918
    rs1440341761,2
    C--103247639(+) TATAAA/GCTCTA 1 -- us2k10--------
    rs1486748441,2
    --103247673(+) GTTATA/TCTGTT 1 -- us2k10--------
    rs47724931,2
    C,F,A,H--103247692(+) TGTTAA/CTTTGA 1 -- us2k133Minor allele frequency- N:0.00EA NA NS CSA WA 3398
    rs1878771051,2
    --103247748(+) AACATC/TCAACT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TPP2 (103249286 - 103331524 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TPP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747910CNV Deletion23290073
    esv2747911CNV Deletion23290073
    esv2306897CNV Deletion18987734

    Human Gene Mutation Database (HGMD): TPP2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TPP2
    DNA2.0 Custom Variant and Variant Library Synthesis for TPP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 190470    OMIM disorders: --


    Find genes that share disorders with TPP2           About GenesLikeMe

    2 Novoseek inferred disease relationships for TPP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    burkitt lymphoma 41.4 6 19787088 (1), 15735022 (1), 17157806 (1)
    tumors 0 10 17671184 (3), 19539606 (2), 18552348 (1), 19155470 (1)

    Genetic Association Database (GAD): TPP2
    Human Genome Epidemiology (HuGE) Navigator: TPP2 (1 document)

    Export disorders for TPP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TPP2 gene, integrated from 10 sources (see all 86):
    (articles sorted by number of sources associating them with TPP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of cDNA for human tripeptidyl peptidase II: the N- terminal part of the enzyme is similar to subtilisin. (PubMed id 1670990)1, 2, 3, 9 Tomkinson B. and Jonsson A.-K. (Biochemistry 1991)
    2. Immunological cross-reactivity between human tripeptidyl peptidase II and fibronectin. (PubMed id 1691635)1, 2, 9 Tomkinson B. and Zetterqvist O. (Biochem. J. 1990)
    3. Nucleotide sequence of cDNA covering the N-terminus of human tripeptidyl peptidase II. (PubMed id 1840501)1, 2, 9 Tomkinson B. (Biomed. Biochim. Acta 1991)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (Proteomics 2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Active site of tripeptidyl peptidase II from human erythrocytes is of the subtilisin type. (PubMed id 3313395)1, 2 Tomkinson B.... Zetterqvist O. (Proc. Natl. Acad. Sci. U.S.A. 1987)
    8. A role for nuclear translocation of tripeptidyl-peptidase II in reactive oxygen species-dependent DNA damage responses. (PubMed id 19747897)2, 9 Preta G.... Glas R. (Biochem. Biophys. Res. Commun. 2009)
    9. Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation. (PubMed id 16849449)1, 9 York I.A....Rock K.L. (J. Immunol. 2006)
    10. Tripeptidyl peptidase II is dispensable for the generation of both proteasome-dependent and proteasome-independent ligands of HLA-B27 and other class I molecules. (PubMed id 18286573)1, 9 Marcilla M....de Castro J.A. (Eur. J. Immunol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7174 HGNC: 12016 AceView: TPP2 Ensembl:ENSG00000134900 euGenes: HUgn7174
    ECgene: TPP2 H-InvDB: TPP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TPP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TPP2 gene:
    Search GeneIP for patents involving TPP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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