TPP2 Gene

Aliases
for TPP2 gene

Previous GC identifers: GC13P101609 GC13P097636 GC13P102086 GC13P100947 GC13P102047 GC13P083841

Summaries
for TPP2 gene

Genomic Views
for TPP2 gene

RefSeq DNA sequence:

NC_000013.10  NC_018924.1  NT_009952.14  

SwitchGear Promoter luciferase reporter plasmid: TPP2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPP2

TPP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P103249:  view genomic region     (about GC identifiers)

Proteins
for TPP2 gene

Explore the universe of human proteins at neXtProt for TPP2: NX_P29144

Post-translational modifications:

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	Enzo Life Sciences proteins for TPP2
	OriGene Purified Protein: TPP2 OriGene Protein Over-expression Lysate: TPP2 OriGene Custom Protein Services for TPP2
	GenScript Custom Purified and Recombinant Proteins Services for TPP2
	Novus Biologicals TPP2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TPP2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Browse OriGene Antibodies OriGene Custom Antibody Services for TPP2
	GenScript Custom Superior Antibodies Services for TPP2
	Novus Biologicals TPP2 Antibody
	Search for Antibodies for TPP2 at Abcam
	Uscn Antibodies for TPP2
	Search ThermoFisher Antibodies for TPP2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TPP2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TPP2

Protein Domains /
Families
for TPP2 gene

ProtoNet protein and cluster: P29144

Function
for TPP2 gene

miRNA Products:		OriGene 3'-UTR Clone: TPP2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TPP2
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate TPP2:
		hsa-miR-3142 hsa-miR-3163 hsa-miR-205 hsa-miR-16-2* hsa-miR-586 hsa-miR-195* hsa-miR-485-3p hsa-miR-570
		SwitchGear 3'UTR luciferase reporter plasmid: TPP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TPP2 (see all 7) OriGene shRNA RFP: TPP2 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TPP2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TPP2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPP2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPP2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TPP2 (NM_003291)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TPP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPP2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TPP2
		Search LifeMap BioReagents cell lines for TPP2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPP2

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Tpp2)

Pathways & Interactions
for TPP2 gene

	Super-pathway	contained gene-specific pathways
1	Immune System	Immune System 1.00 Adaptive Immune System 0.59
2	Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation 1.00 Class I MHC mediated antigen processing & presentation 0.83
3	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases 1.00

5        Reactome Pathways for TPP2

	Antigen processing: Ubiquitination & Proteasome degradation
	Adaptive Immune System
	Class I MHC mediated antigen processing & presentation
	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases
	Immune System

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for TPP2 gene

Transcripts
for TPP2 gene

Expression
for TPP2 gene

TPP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATAAATTTG

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	KidneyCap MesenchymeCap Mesenchyme Cells			Kidney
	KidneyS-shaped Body			Kidney
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Late limb mesenchymal cells (LLM cells) (Primary Cell)			Bone, Cartilage, Limb

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TPP2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TPP2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPP2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPP2

Orthologs
for TPP2 gene

Paralogs
for TPP2 gene

Genomic Variants
for TPP2 gene

10/1537 NCBI SNPs in TPP2 are shown (see all 1537)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1904759431,2		--	103247451(+)	TACTCA/TGGCAA	1	--	us2k1		0	--	--	--	--
rs1831781071,2		--	103247512(+)	CAAATA/CCCGTG	1	--	us2k1		0	--	--	--	--
rs175068751,2	C,F,H,	--	103247514(+)	AATCCC/AGTGTT	1	--	us2k1		28		NA NS EA WA	3048
rs47724911,2	C,F,A,H,	--	103247603(+)	GTTCAT/CTTGAA	1	--	us2k1 tfbs3		34		NA NS EA WA CSA	3335
rs47724921,2	C,F,A,H,	--	103247624(+)	ATTCTA/GTTCTA	1	--	us2k1		32		NA NS EA WA CSA	2918
rs1440341761,2		--	103247639(+)	TATAAA/GCTCTA	1	--	us2k1		0	--	--	--	--
rs1486748441,2		--	103247673(+)	GTTATA/TCTGTT	1	--	us2k1		0	--	--	--	--
rs47724931,2	C,F,A,H,	--	103247692(+)	TGTTAA/CTTTGA	1	--	us2k1		33		EA NA NS CSA WA	3398
rs1878771051,2		--	103247748(+)	AACATC/TCAACT	1	--	us2k1		0	--	--	--	--
rs169602321,2	C,F,H,	--	103247800(+)	ACTTAT/CGGACT	1	--	us2k1		17		NA NS EA CSA WA	1776

HapMap Linkage Disequilibrium report for TPP2 (103249286 - 103331524 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TPP2
     1 Indel: 45104
Human Gene Mutation Database (HGMD): TPP2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPP2

DNA2.0 Custom Variant and Variant Library Synthesis for TPP2

Disorders / Diseases
for TPP2 gene

10 diseases for TPP2

2 Novoseek disease relationships for TPP2 gene    About this table

Publications
for TPP2 gene

PubMed articles for TPP2 gene, integrated from 9 sources (see all 85): (articles sorted by number of sources associating them with TPP2)

Utopia: connect your pdf to the dynamic world of online information

1. Characterization of cDNA for human tripeptidyl peptidase II: the N- terminal part of the enzyme is similar to subtilisin. (PubMed id 1670990)^{1, 2, 3, 9} Tomkinson B. and Jonsson A.-K. (1991)
2. Immunological cross-reactivity between human tripeptidyl peptidase II and fibronectin. (PubMed id 1691635)^{1, 2, 9} Tomkinson B. and Zetterqvist O. (1990)
3. Nucleotide sequence of cDNA covering the N-terminus of human tripeptidyl peptidase II. (PubMed id 1840501)^{1, 2, 9} Tomkinson B. (1991)
4. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)^{1, 2} Denis N.J.... Figeys D. (2007)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. Active site of tripeptidyl peptidase II from human erythrocytes is of the subtilisin type. (PubMed id 3313395)^{1, 2} Tomkinson B.... Zetterqvist O. (1987)
7. A role for nuclear translocation of tripeptidyl-pepti dase II in reactive oxygen species-dependent DNA damage responses. (PubMed id 19747897)^{2, 9} Preta G....Glas R. (2009)
8. Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation. (PubMed id 16849449)^{1, 9} York I.A....Rock K.L. (2006)
9. Tripeptidyl peptidase II is dispensable for the generation of both proteasome-dependent and proteasome-independent ligands of HLA-B27 and other class I molecules. (PubMed id 18286573)^{1, 9} Marcilla M....de Castro J.A. (2008)
10. Characterization of the promoter of the gene encoding human tripeptidyl-peptidase II and identification of upstream silencer elements. (PubMed id 17343995)^{1, 9} Lindas A.C. and Tomkinson B. (2007)

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Products
for TPP2 gene