Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TPP2 Gene

Aliases for TPP2 Gene

  • Tripeptidyl Peptidase 2 2 3 5
  • Tripeptidyl Aminopeptidase 3 4
  • Tripeptidyl-Peptidase II 3 4
  • EC 3.4.14.10 4 61
  • TPP-II 3 4
  • TPP-2 3 4
  • Tripeptidyl Peptidase II 2
  • Tripeptidyl-Peptidase 2 3
  • TPPII 3

External Ids for TPP2 Gene

Previous GeneCards Identifiers for TPP2 Gene

  • GC13P101609
  • GC13P097636
  • GC13P102086
  • GC13P100947
  • GC13P102047
  • GC13P103249
  • GC13P083841

Summaries for TPP2 Gene

Entrez Gene Summary for TPP2 Gene

  • This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]

GeneCards Summary for TPP2 Gene

TPP2 (Tripeptidyl Peptidase 2) is a Protein Coding gene. Diseases associated with TPP2 include Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome and Evans Syndrome With Immunodeficiency And Premature Immunosenescence. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include serine-type endopeptidase activity and peptide binding.

UniProtKB/Swiss-Prot for TPP2 Gene

  • Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis (By similarity).

Gene Wiki entry for TPP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPP2 Gene

Genomics for TPP2 Gene

Regulatory Elements for TPP2 Gene

Enhancers for TPP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F102594 1.5 FANTOM5 ENCODE 21.9 +0.4 382 5.2 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TPP2 ERCC5 METTL21C GC13P102663
GH13F102772 1 ENCODE 16.3 +176.8 176766 2.6 HDGF ATF1 CREB3L1 SIN3A GLI4 YY1 GLIS2 ZNF143 KDM4B KLF13 TPP2 METTL21EP PIR36999 TEX30
GH13F102844 1.1 ENCODE 11.6 +249.6 249564 3.9 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 BIVM TPP2 TEX30 METTL21EP CCDC168 LINC00283 ERCC5 METTL21C GC13M102871
GH13F101751 1.2 FANTOM5 Ensembl ENCODE 4.7 -845.2 -845180 1.0 GTF2F1 STAT1 JUN CEBPB USF2 EP300 BRCA1 RFX5 MAFF SMARCA4 RNU1-24P HMGB3P7 TPP2 NALCN GC13P101758 GC13M101719
GH13F102591 1.3 FANTOM5 ENCODE 3 -4.5 -4492 1.9 HDGF ARID4B SIN3A ZNF2 GLIS2 ZNF143 ZNF207 SP3 MXD4 REST LINC00283 CCDC168 TPP2 ERCC5 LINC00555 ENSG00000276957
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TPP2 on UCSC Golden Path with GeneCards custom track

Promoters for TPP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000667254 264 3601 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for TPP2 Gene

Chromosome:
13
Start:
102,596,936 bp from pter
End:
102,679,958 bp from pter
Size:
83,023 bases
Orientation:
Plus strand

Genomic View for TPP2 Gene

Genes around TPP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPP2 Gene

Proteins for TPP2 Gene

  • Protein details for TPP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29144-TPP2_HUMAN
    Recommended name:
    Tripeptidyl-peptidase 2
    Protein Accession:
    P29144
    Secondary Accessions:
    • Q5VZU8

    Protein attributes for TPP2 Gene

    Size:
    1249 amino acids
    Molecular mass:
    138350 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The limitation of proteolytic products to tripeptides is achieved by tailoring the size of the substrate-binding cleft: the two negatively charged residues Glu-305 and Glu-331 that are blocking position P4 limit the number of residues that can be accommodated in the binding cleft and thus create a molecular ruler. At the same time, they orient substrates so that the tripeptides are removed exclusively from the N-terminus (By similarity).

neXtProt entry for TPP2 Gene

Selected DME Specific Peptides for TPP2 Gene

P29144:
  • VLRNYKEAQEY
  • AANAVISHIDQTALAVYIAMKTDPRPDAA
  • SQANKLIKEEL
  • NIRVDPRGLREGLHYTEVCGYDIASPNAGPLFRVPITAVI
  • KLVEEKP
  • LDTGVDPGAPG
  • QLMNGTSM
  • SFHGIVCTAPQLNIH
  • SQVELLNSFEKKYSDPGPVYDCLVW
  • VSSAGNNGP
  • APGGAIASVP

Post-translational modifications for TPP2 Gene

  • Ubiquitination at Lys 19, Lys 1005, Lys 1013, Lys 1180, and Lys 1187
  • Modification sites at PhosphoSitePlus

Other Protein References for TPP2 Gene

Domains & Families for TPP2 Gene

Suggested Antigen Peptide Sequences for TPP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P29144

UniProtKB/Swiss-Prot:

TPP2_HUMAN :
  • Contains 1 peptidase S8 domain.
  • Belongs to the peptidase S8 family.
Domain:
  • Contains 1 peptidase S8 domain.
Family:
  • Belongs to the peptidase S8 family.
genes like me logo Genes that share domains with TPP2: view

No data available for Gene Families for TPP2 Gene

Function for TPP2 Gene

Molecular function for TPP2 Gene

GENATLAS Biochemistry:
tripeptidyl peptidase 2
UniProtKB/Swiss-Prot CatalyticActivity:
Release of an N-terminal tripeptide from a polypeptide.
UniProtKB/Swiss-Prot Function:
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis (By similarity).

Enzyme Numbers (IUBMB) for TPP2 Gene

Gene Ontology (GO) - Molecular Function for TPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity TAS 9974389
GO:0004177 aminopeptidase activity EXP 9668046
GO:0004252 serine-type endopeptidase activity IEA,IBA --
GO:0005515 protein binding IPI 25416956
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with TPP2: view
genes like me logo Genes that share phenotypes with TPP2: view

Animal Models for TPP2 Gene

MGI Knock Outs for TPP2:

Animal Model Products

miRNA for TPP2 Gene

miRTarBase miRNAs that target TPP2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TPP2 Gene

Localization for TPP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPP2 Gene

Cytoplasm. Nucleus. Note=Translocates to the nucleus in responce to gamma-irradiation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPP2 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TPP2: view

Pathways & Interactions for TPP2 Gene

genes like me logo Genes that share pathways with TPP2: view

Pathways by source for TPP2 Gene

Gene Ontology (GO) - Biological Process for TPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with TPP2: view

No data available for SIGNOR curated interactions for TPP2 Gene

Drugs & Compounds for TPP2 Gene

(1) Drugs for TPP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for TPP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TPP2: view

Transcripts for TPP2 Gene

Unigene Clusters for TPP2 Gene

Tripeptidyl peptidase II:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a ·
SP1: - -
SP2: -
SP3: -
SP4: -
SP5: - -
SP6: - - - -
SP7: - - -
SP8: - - -
SP9:
SP10:
SP11:

ExUns: 21b ^ 22a · 22b · 22c ^ 23a · 23b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TPP2 Gene

GeneLoc Exon Structure for
TPP2
ECgene alternative splicing isoforms for
TPP2

Expression for TPP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TPP2 Gene

Protein differential expression in normal tissues from HIPED for TPP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.4), Lymph node (9.7), and Retina (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TPP2 Gene



Protein tissue co-expression partners for TPP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TPP2 Gene:

TPP2

SOURCE GeneReport for Unigene cluster for TPP2 Gene:

Hs.432424
genes like me logo Genes that share expression patterns with TPP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TPP2 Gene

Orthologs for TPP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TPP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPP2 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia TPP2 34 35
  • 92.82 (n)
rat
(Rattus norvegicus)
Mammalia Tpp2 34
  • 90.77 (n)
mouse
(Mus musculus)
Mammalia Tpp2 34 16 35
  • 90.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TPP2 35
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TPP2 34 35
  • 87.86 (n)
oppossum
(Monodelphis domestica)
Mammalia TPP2 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves TPP2 34 35
  • 81.33 (n)
lizard
(Anolis carolinensis)
Reptilia TPP2 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tpp2 34
  • 75.45 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20720 34
zebrafish
(Danio rerio)
Actinopterygii TPP2 35
  • 74 (a)
OneToOne
tpp2 34
  • 66.27 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004870 34
  • 49.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta TppII 36 34 35
  • 48.47 (n)
worm
(Caenorhabditis elegans)
Secernentea F21H12.6 36 34
  • 48.61 (n)
tpp-2 35
  • 33 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons TPP2 34
  • 49.78 (n)
rice
(Oryza sativa)
Liliopsida Os02g0664300 34
  • 51 (n)
Os.27950 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tpp2 34
  • 48.41 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14849 34
Species where no ortholog for TPP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPP2 Gene

ENSEMBL:
Gene Tree for TPP2 (if available)
TreeFam:
Gene Tree for TPP2 (if available)

Paralogs for TPP2 Gene

No data available for Paralogs for TPP2 Gene

Variants for TPP2 Gene

Sequence variations from dbSNP and Humsavar for TPP2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs10508092 -- 102,619,147(+) AGATA(A/G)TGGTG intron-variant
rs10508093 -- 102,673,261(+) TACTG(C/T)GGATC intron-variant
rs10530428 -- 102,652,398(+) CATAC(-/ATATATATATATATATATATATATATATATATAT)ATATA intron-variant
rs10559731 -- 102,645,984(+) TTTTA(-/GTT)GTCAC intron-variant
rs1062085 -- 102,679,072(+) AAAAC(A/C)CATGA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TPP2 Gene

Variant ID Type Subtype PubMed ID
esv2306897 CNV deletion 18987734
esv2747910 CNV deletion 23290073
esv2747911 CNV deletion 23290073
esv3580867 CNV loss 25503493
nsv473907 CNV novel sequence insertion 20440878
nsv476294 CNV novel sequence insertion 20440878
nsv480645 CNV novel sequence insertion 20440878
nsv562980 CNV loss 21841781
nsv976263 CNV duplication 23825009

Variation tolerance for TPP2 Gene

Residual Variation Intolerance Score: 5.24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPP2 Gene

Human Gene Mutation Database (HGMD)
TPP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TPP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPP2 Gene

Disorders for TPP2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TPP2 Gene - From: GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome
  • evans syndrome associated with primary immunodeficiency
evans syndrome with immunodeficiency and premature immunosenescence
evans' syndrome
  • malignant tumor of retromolar area
- elite association - COSMIC cancer census association via MalaCards
Search TPP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TPP2

Genetic Association Database (GAD)
TPP2
Human Genome Epidemiology (HuGE) Navigator
TPP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPP2
genes like me logo Genes that share disorders with TPP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPP2 Gene

Publications for TPP2 Gene

  1. Characterization of cDNA for human tripeptidyl peptidase II: the N- terminal part of the enzyme is similar to subtilisin. (PMID: 1670990) Tomkinson B. … Jonsson A.-K. (Biochemistry 1991) 2 3 4 22 64
  2. Nucleotide sequence of cDNA covering the N-terminus of human tripeptidyl peptidase II. (PMID: 1840501) Tomkinson B. (Biomed. Biochim. Acta 1991) 3 4 22 64
  3. Immunological cross-reactivity between human tripeptidyl peptidase II and fibronectin. (PMID: 1691635) Tomkinson B. … Zetterqvist O. (Biochem. J. 1990) 3 4 22 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Processing of two latent membrane protein 1 MHC class I epitopes requires tripeptidyl peptidase II involvement. (PMID: 19587004) Diekmann J. … Topp M.S. (J. Immunol. 2009) 3 22 64

Products for TPP2 Gene

Sources for TPP2 Gene

Content
Loading form....