Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TPP2 Gene

Aliases for TPP2 Gene

  • Tripeptidyl Peptidase II 2 3
  • Tripeptidyl Aminopeptidase 3 4
  • Tripeptidyl-Peptidase II 3 4
  • EC 3.4.14.10 4 64
  • TPP-II 3 4
  • TPP-2 3 4
  • Tripeptidyl-Peptidase 2 3

External Ids for TPP2 Gene

Summaries for TPP2 Gene

Entrez Gene Summary for TPP2 Gene

  • This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]

GeneCards Summary for TPP2 Gene

TPP2 (Tripeptidyl Peptidase II) is a Protein Coding gene. Diseases associated with TPP2 include protein s deficiency. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include serine-type endopeptidase activity and endopeptidase activity.

UniProtKB/Swiss-Prot for TPP2 Gene

  • Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis (By similarity).

Gene Wiki entry for TPP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPP2 Gene

Genomics for TPP2 Gene

Genomic Location for TPP2 Gene

Start:
102,596,936 bp from pter
End:
102,679,958 bp from pter
Size:
83,023 bases
Orientation:
Plus strand

Genomic View for TPP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPP2 Gene

Regulatory Elements for TPP2 Gene

Proteins for TPP2 Gene

  • Protein details for TPP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29144-TPP2_HUMAN
    Recommended name:
    Tripeptidyl-peptidase 2
    Protein Accession:
    P29144
    Secondary Accessions:
    • Q5VZU8

    Protein attributes for TPP2 Gene

    Size:
    1249 amino acids
    Molecular mass:
    138350 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The limitation of proteolytic products to tripeptides is achieved by tailoring the size of the substrate-binding cleft: the two negatively charged residues Glu-305 and Glu-331 that are blocking position P4 limit the number of residues that can be accommodated in the binding cleft and thus create a molecular ruler. At the same time, they orient substrates so that the tripeptides are removed exclusively from the N-terminus (By similarity).

neXtProt entry for TPP2 Gene

Proteomics data for TPP2 Gene at MOPED

Post-translational modifications for TPP2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys19, Lys1005, Lys1013, Lys1180, and Lys1187

Other Protein References for TPP2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for TPP2 Gene

UniProtKB/Swiss-Prot:

TPP2_HUMAN
Domain:
  • Contains 1 peptidase S8 domain.:
    • P29144
Family:
  • Belongs to the peptidase S8 family.:
    • P29144
genes like me logo Genes that share domains with TPP2: view

No data available for Gene Families for TPP2 Gene

Function for TPP2 Gene

Molecular function for TPP2 Gene

GENATLAS Biochemistry: tripeptidyl peptidase 2
UniProtKB/Swiss-Prot CatalyticActivity: Release of an N-terminal tripeptide from a polypeptide.
UniProtKB/Swiss-Prot Function: Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis (By similarity).

Enzyme Numbers (IUBMB) for TPP2 Gene

Gene Ontology (GO) - Molecular Function for TPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity TAS 9974389
GO:0004177 aminopeptidase activity IEA --
GO:0004252 serine-type endopeptidase activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0008240 tripeptidyl-peptidase activity IEA --
genes like me logo Genes that share ontologies with TPP2: view
genes like me logo Genes that share phenotypes with TPP2: view

Animal Models for TPP2 Gene

MGI Knock Outs for TPP2:

miRNA for TPP2 Gene

miRTarBase miRNAs that target TPP2

No data available for Transcription Factor Targeting and HOMER Transcription for TPP2 Gene

Localization for TPP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPP2 Gene

Cytoplasm. Nucleus. Note=Translocates to the nucleus in responce to gamma-irradiation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPP2 Gene COMPARTMENTS Subcellular localization image for TPP2 gene
Compartment Confidence
nucleus 5
cytosol 4
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TPP2: view

Pathways for TPP2 Gene

genes like me logo Genes that share pathways with TPP2: view

Gene Ontology (GO) - Biological Process for TPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0006508 proteolysis IBA --
genes like me logo Genes that share ontologies with TPP2: view

Compounds for TPP2 Gene

(3) Novoseek inferred chemical compound relationships for TPP2 Gene

Compound -log(P) Hits PubMed IDs
ala-ala-phe-chloromethyl ketone 94.3 3
tripeptide s 75.8 3
serine 50.1 11
genes like me logo Genes that share compounds with TPP2: view

Transcripts for TPP2 Gene

Unigene Clusters for TPP2 Gene

Tripeptidyl peptidase II:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a ·
SP1: - -
SP2: -
SP3: -
SP4: -
SP5: - -
SP6: - - - -
SP7: - - -
SP8: - - -
SP9:
SP10:
SP11:

ExUns: 21b ^ 22a · 22b · 22c ^ 23a · 23b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TPP2 Gene

GeneLoc Exon Structure for
TPP2
ECgene alternative splicing isoforms for
TPP2

Expression for TPP2 Gene

mRNA expression in normal human tissues for TPP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPP2 Gene

SOURCE GeneReport for Unigene cluster for TPP2 Gene Hs.432424

genes like me logo Genes that share expressions with TPP2: view

Orthologs for TPP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TPP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPP2 36
  • 99.52 (n)
  • 99.68 (a)
TPP2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TPP2 36
  • 87.86 (n)
  • 96.64 (a)
TPP2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPP2 36
  • 92.82 (n)
  • 96.88 (a)
TPP2 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tpp2 36
  • 90.37 (n)
  • 96.32 (a)
Tpp2 16
Tpp2 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TPP2 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TPP2 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tpp2 36
  • 90.77 (n)
  • 96.8 (a)
chicken
(Gallus gallus)
Aves TPP2 36
  • 81.33 (n)
  • 86.12 (a)
TPP2 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TPP2 37
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20720 36
tropical clawed frog
(Silurana tropicalis)
Amphibia tpp2 36
  • 75.45 (n)
  • 81.91 (a)
zebrafish
(Danio rerio)
Actinopterygii tpp2 36
  • 66.27 (n)
  • 75.08 (a)
TPP2 37
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004870 36
  • 49.26 (n)
  • 42.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta TppII 36
  • 48.47 (n)
  • 41.24 (a)
TppII 37
  • 33 (a)
OneToOne
TppII 38
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea F21H12.6 36
  • 48.61 (n)
  • 38.15 (a)
tpp-2 37
  • 33 (a)
OneToOne
F21H12.6 38
  • 37 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons TPP2 36
  • 49.78 (n)
  • 40.51 (a)
rice
(Oryza sativa)
Liliopsida Os.27950 36
Os02g0664300 36
  • 51 (n)
  • 42.79 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tpp2 36
  • 48.41 (n)
  • 36.92 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14849 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
OneToOne
Species with no ortholog for TPP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPP2 Gene

ENSEMBL:
Gene Tree for TPP2 (if available)
TreeFam:
Gene Tree for TPP2 (if available)

Paralogs for TPP2 Gene

No data available for Paralogs for TPP2 Gene

Variants for TPP2 Gene

Sequence variations from dbSNP and Humsavar for TPP2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs3806 -- 102,678,368(+) AATGG(A/G)TATAA utr-variant-3-prime, nc-transcript-variant
rs581614 -- 102,660,195(-) tttta(G/T)ttttt intron-variant
rs582372 -- 102,675,736(+) GTGTC(C/T)ATGGC intron-variant
rs582767 -- 102,654,326(-) TACAT(A/G)TTAAA intron-variant
rs582853 -- 102,650,382(-) ATGGC(C/T)TTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPP2 Gene

Variant ID Type Subtype PubMed ID
esv2306897 CNV Deletion 18987734
esv2747910 CNV Deletion 23290073
esv2747911 CNV Deletion 23290073

Relevant External Links for TPP2 Gene

HapMap Linkage Disequilibrium report
TPP2
Human Gene Mutation Database (HGMD)
TPP2

Disorders for TPP2 Gene

(1) MalaCards Diseases for TPP2 Gene

Search for TPP2 Gene in MalaCards »

(2) Novoseek inferred disease relationships for TPP2 Gene

Disease -log(P) Hits PubMed IDs
burkitt lymphoma 41.4 3
tumors 0 7

Relevant External Links for TPP2

Genetic Association Database (GAD)
TPP2
Human Genome Epidemiology (HuGE) Navigator
TPP2
genes like me logo Genes that share disorders with TPP2: view

No data available for UniProtKB/Swiss-Prot for TPP2 Gene

Publications for TPP2 Gene

  1. Characterization of cDNA for human tripeptidyl peptidase II: the N- terminal part of the enzyme is similar to subtilisin. (PMID: 1670990) Tomkinson B. … Jonsson A.-K. (Biochemistry 1991) 2 3 4 23
  2. Immunological cross-reactivity between human tripeptidyl peptidase II and fibronectin. (PMID: 1691635) Tomkinson B. … Zetterqvist O. (Biochem. J. 1990) 3 4 23
  3. Nucleotide sequence of cDNA covering the N-terminus of human tripeptidyl peptidase II. (PMID: 1840501) Tomkinson B. (Biomed. Biochim. Acta 1991) 3 4 23
  4. Purification and characterization of tripeptidylpeptidase-II from post-mortem human brain. (PMID: 8396212) Wilson C. … McDermott J.R. (Neurochem. Res. 1993) 3 23
  5. Localization of the human tripeptidyl peptidase II gene (TPP2) to 13q32-q33 by nonradioactive in situ hybridization and somatic cell hybrids. (PMID: 8406500) Martinsson T. … Tomkinson B. (Genomics 1993) 3 23

Products for TPP2 Gene

Sources for TPP2 Gene

Back to Top

Content