Aliases for TPO Gene
External Ids for TPO Gene
Previous GeneCards Identifiers for TPO Gene
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]
GeneCards Summary for TPO Gene
TPO (Thyroid Peroxidase) is a Protein Coding gene. Diseases associated with TPO include Thyroid Dyshormonogenesis 2A and Congenital Hypothyroidism. Among its related pathways are Amine-derived hormones and Differentiation Pathway. GO annotations related to this gene include calcium ion binding and peroxidase activity. An important paralog of this gene is PXDN.
UniProtKB/Swiss-Prot for TPO Gene
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).