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TPO Gene

protein-coding GIFtS: 65

GC02P001396

thyroid peroxidase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 1.11.1.8 ^³
MSA ^²
OTTHUMP00000115304 ^²
OTTHUMP00000115536 ^²
TPX ^¹, ², ⁵
thyroperoxidase ^²

Descriptions
thyroid microsomal antigen ^²
thyroid peroxidase ^²

External Ids
HGNC: 12015¹
Entrez Gene: 7173²
UniProtKB: P07202³
Ensembl: ENSG00000115705⁷

Search outside databases for aliases for TPO gene

Previous GC identifers: GC02P001422 GC02P001360

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TPO:

This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a

central role in thyroid gland function. The protein functions in the iodination of tyrosine

residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to

generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are

associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism,

congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants

encoding distinct isoforms have been identified for this gene. Additional splice variants have

been described but their biological natures have not been determined. [provided by RefSeq]

UniProtKB/Swiss-Prot: PERT_HUMAN, P07202

Function: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the

thyroid hormones T(3) and T(4)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TPO gene

Entrez Gene cytogenetic band: 2p25 Ensembl cytogenetic band: 2p25.3 HGNC cytogenetic band: 2p25

TPO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P001396: (about GC identifiers)

Start:	1,396,242 bp from pter
End:	1,525,502 bp from pter
Size:	129,261 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_022221.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PERT_HUMAN, P07202 (See protein sequence)

Recommended Name: Thyroid peroxidase precursor

Size: 933 amino acids; 102963 Da

Cofactor: Binds 1 calcium ion per heterodimer (By similarity)

Cofactor: Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer (By similarity)

Subunit: Interacts with DUOX1, DUOX2 and CYBA

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: P09934 P09935 Q8IUL0 Q8NF94 Q8NF95 Q8NF96 Q8NF97 Q8TCI9

Alternative splicing: 8 isoforms: P07202-1 P07202-2 P07202-3 P07202-4 P07202-5 P07202-6 P07202-7 P07202-8

(Additional isoforms seem to exist)

Post-translational modifications:

Glycosylated¹

Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is

important for the delivery of protein at the cell surface¹

Cleaved in its N-terminal part¹

REFSEQ proteins (4 alternative transcripts):

NP_000538.3 NP_783650.1 NP_783652.1 NP_783653.1

ENSEMBL proteins:

ENSP00000312591 ENSP00000371633 ENSP00000371704 ENSP00000329869 ENSP00000371636 ENSP00000332044

ENSP00000263886 ENSP00000318820 ENSP00000337263

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Thyroid Peroxidase)
	Human Recombinant Proteins from Abnova (TPO)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	18029348
GO:0005887	integral to plasma membrane	TAS	2548579
GO:0016020	membrane	IEA	--

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Antibodies for TPO:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TPO
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Thyroid Peroxidase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TPO)
	Novus Biologicals Antibodies for TPO

Assays for TPO:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P07202

ProtoNet protein and cluster: P07202

5 Blocks protein families:

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB000436 Sushi domain/SCR domain/CCP module

IPB001881 EGF-like calcium-binding

IPB002007 Animal haem peroxidase signature

IPB010255 Haem peroxidase

UniProtKB/Swiss-Prot: PERT_HUMAN, P07202

Similarity: Belongs to the peroxidase family. XPO subfamily

Similarity: Contains 1 EGF-like domain

Similarity: Contains 1 Sushi (CCP/SCR) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TPO)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TPO)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_000547

Applied Biosystems Silencer® siRNAs for TPO

Sigma-Aldrich siRNA and siRNA Panels for TPO

Sigma-Aldrich shRNA Panels and shRNA for TPO

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TPO
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_000547
Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_000547
untagged cDNA clones in CMV expression vector (see all 5): NM_000547

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000547

UniProtKB/Swiss-Prot: PERT_HUMAN, P07202

Function: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the

thyroid hormones T(3) and T(4)

Catalytic activity: 2 iodide + H(2)O(2) + 2 H(+) = 2 iodine + 2 H(2)O

Enzyme Number (IUBMB): EC 1.11.1.8

Genatlas biochemistry entry for TPO:

thyroid peroxidase,thyroid hormone synthesis (iodide organification) and metabolism pathway

6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tpo):

endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism	immune system
life span-post-weaning/aging

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004447	iodide peroxidase activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0020037	heme binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for TPO (Your Favorite Gene powered by Ingenuity)

Autoimmune Thyroid Disease Signaling
Phenylalanine Metabolism
Tyrosine Metabolism
Stilbene, Coumarine and Lignin Biosynthesis
Methane Metabolism

GeneDecks TPO for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: PERT_HUMAN, P07202

Pathway: Hormone biosynthesis; thyroid hormone biosynthesis

Gene Network Central^TM Interacting Genes and Proteins Network for TPO

5/46 Interacting proteins for TPO (ENSP00000329869³) via UniProtKB, MINT, and/or STRING (see all 46 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TG	ENSP00000220616³	STRING (score=.968)
SLC5A5	ENSP00000222248³	STRING (score=.967)
TSHR	ENSP00000298171³	STRING (score=.963)
IYD	ENSP00000229447³	STRING (score=.959)
SLC26A4	ENSP00000265715³	STRING (score=.945)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006979	response to oxidative stress	IEA	--
GO:0042446	hormone biosynthetic process	IEA	--
GO:0042744	hydrogen peroxide catabolic process	IEA	--
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TPO
10/53 Novoseek chemical compound relationships for TPO gene (see all 53 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
iodide	88.75	202	7711505 (5), 11061528 (3), 8369653 (3), 9924196 (3) (see all 91)
iodine	84.11	97	8900403 (2), 10433193 (2), 17505148 (2), 16277169 (2) (see all 56)
sp(1-4)	83.32	12	9062508 (2), 8814323 (2), 7512572 (2), 7714125 (1)
triiodothyronine	79.68	80	2081735 (3), 16440845 (2), 2387197 (1), 7775728 (1) (see all 56)
sodium iodide	78.51	29	19050049 (2), 10090312 (1), 18430446 (1), 11762710 (1) (see all 19)
diiodotyrosine	72.87	4	8196170 (2), 8900403 (1), 1318692 (1)
iodotyrosine	64.46	1	9506870 (1)
perchlorate	62.34	7	10468986 (1), 14751036 (1), 16424561 (1), 17318546 (1) (see all 6)
atpo	59.76	3	11703366 (1), 18812059 (1), 16912122 (1)
ethylenethiourea	41.77	4	2130946 (3)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TPO)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TPO)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_000547

Sigma-Aldrich siRNA and siRNA Panels for TPO

Sigma-Aldrich shRNA Panels and shRNA for TPO

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000547 NM_175719 NM_175721 NM_175722

REFSEQ mRNAs for TPO gene (4 alternative transcripts):

NM_000547.4 NM_175719.2 NM_175721.2 NM_175722.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000547 NM_175719 NM_175721 NM_175722

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_000547
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_000547
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_000547

Additional cDNA sequence:

AF439430.1 AF533528.1 AF533529.1 AF533530.1 AF533531.1 AK309868.1 AY136822.1 BC063107.1

BC095448.1 BC131807.1 J02969.1 J02970.1 M17755.2 M55702.1 X17358.1 Y00406.1

10 DOTS entries:

DT.441094 DT.100781937 DT.100022296 DT.95080660 DT.424270 DT.97837233 DT.95080663 DT.101955958

DT.40207443 DT.121617867

24/75 AceView cDNA sequences (see all 75 ):

AA385888 NM_175722 AA384782 AA385749 NM_175720 AW058262 NM_175719 AA384872

AA309509 AU141148 AA384833 NM_175721 NM_000547 BI002131 AI732567 J02969

AA385595 AF533528 AW873960 AL044455 BV203089 CA447999 AW874079 AW874069

highest scoring ESTs for TPO:

J02969 AA309509 AA384625 AA384833 AA385749 AF439430 AF533529 AJ573347 AW137846 AW873387

Unigene Cluster for TPO:

Thyroid peroxidase

Hs.467554 [show with all ESTs]

Unigene Representative Sequence: NM_000547

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TPO (see all 6 )

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18a	·	18b
SP1:															-																								-
SP2:															-																								-
SP3:															-										-														-
SP4:															-										-														-
SP5:															-																		-

About this scheme

ECgene alternative splicing isoforms for TPO

9 Ensembl transcripts including schematic representations:

ENST00000308422 ENST00000382198 ENST00000382269 ENST00000329066 ENST00000382201 ENST00000349624

ENST00000346956 ENST00000345913 ENST00000337415

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TPO expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TPO

¹ / ² / ³

3 probe-sets matching TPO gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35928_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	J02969	1.00	1.00	1.00	1
210342_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M17755	0.80	1.00	0.91	1
210342_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks TPO for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GATGAATAAA

SOURCE GeneReport for Unigene cluster: Hs.467554
Expression variation in blood from EXPOLDB for TPO

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TPO gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TPO¹	--	thyroid peroxidase	76.49(n) 71.29(a)	403521 NM_001003009.1 NP_001003009.1
cow (Bos taurus)	TPO¹	--	thyroid peroxidase	77.7(n) 75.44(a)	525013 XM_603356.3 XP_603356.3
rat (Rattus norvegicus)	Tpo¹	--	thyroid peroxidase	77.38(n) 76.24(a)	54314 NM_019353.1 NP_062226.1
mouse (Mus musculus)	Tpo^{1, 5}	12 (15.00 cM)⁵	thyroid peroxidase^{1, 5}	76.83(n)¹ 75.47(a)¹	22018¹ NM_009417.2¹ NP_033443.1¹ AK047843⁵ BC099421⁵ (see all 7)
chicken (Gallus gallus)	TPO¹	--	thyroid peroxidase	65.9(n) 68.23(a)	776120 XM_001235672.1 XP_001235673.1

About this table Species with no ortholog for TPO

ENSEMBL Gene Tree for TPO

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TPO gene

PXDNL² PXDN²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1511 NCBI SNPs in TPO are shown (see all 1511 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 532)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2071403^1,2	A,C,F,H,O	1396251(+)	`CAATTG/AAGGCG`	4	--	ut5¹		21	NA EU EA WA NS	1658
	rs2071399^1,2	A,C,F,H,O	1395535(+)	`GGAGCG/AGGTCA`	4	--	ng5¹		7	EU EA WA NA	552
	rs2298876^1,2	C,F,H,O	1395044(+)	`AAACCA/GAGGAT`	4	--	ng5¹		17	EA NA NS EU WA	2632
	rs2071402^1,2	C,F,H,O	1396206(+)	`AGCGCG/AGAGTC`	4	--	ng5¹		22	EA NA EU WA NS	3156
	rs13431173^1,2	A,C,F,H	1478877(+)	`TGCCCA/GTGGAT`	4	M/V	mis¹ ese³		14	NS EU EA WA NA	1098
	rs1042589^1,2	A,C,F,H	1525334(+)	`AAATCC/GGAAAT`	4	--	ut3¹		18	NA MN EU EA WA NS	1428
	rs2071401^1,2	A,C,F,H	1396146(+)	`ATTCTG/TTCCCC`	4	--	ng5¹		9	EU EA WA NS	598
	rs4927604^1,2	A,C,F,H	1395442(+)	`GGAGAG/AGGGAA`	4	--	ng5¹ trp³		4	EU EA WA	406
	rs2071400^1,2	A,C,F,H	1395646(+)	`GTGACC/TTTCCT`	4	--	ng5¹		4	EU EA WA	412
	rs732609^1,2	A,C,F,H	1478934(+)	`GCATCA/CCTGGC`	4	T/P	mis¹ ese³		20	MN EU EA WA NA NS	1602

About this table

HapMap Linkage Disequilibrium images for TPO (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 606765

UniProtKB/Swiss-Prot: PERT_HUMAN, P07202

An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease

Defects in TPO are the cause of congenital hypothyroidism due to dyshormonogenesis type 2A

(CHDH2A) [MIM:274500]; also called genetic defect in thyroid hormonogenesis 2A or thyroid hormone

organification defect II. CHDH2A is due to defective conversion of accumulated iodide to

organically bound iodine. The iodide organification defect can be partial or complete

10/92 Novoseek disease relationships for TPO gene (see all 92 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
autoimmune thyroid disease	96.12	225	1702446 (4), 10520899 (3), 2256432 (2), 8375572 (2) (see all 99)
hashimotos thyroiditis	91.70	99	2242608 (3), 8067701 (3), 8603516 (3), 2330843 (2) (see all 62)
graves disease	91.18	123	8257863 (3), 8187932 (2), 11092696 (2), 8408460 (2) (see all 69)
dysfunction thyroid	91.09	24	11148327 (2), 2387197 (1), 11078988 (1), 15320974 (1) (see all 18)
thyroid dysfunction postpartum	91.08	12	17845204 (2), 10999807 (1), 15320974 (1), 9828915 (1) (see all 11)
thyroid diseases	90.84	95	15958307 (4), 9508203 (3), 8808096 (2), 16756464 (2) (see all 58)
hypothyroidism	90.27	78	15853828 (2), 1668285 (2), 12663594 (2), 16647667 (2) (see all 61)
thyroiditis	89.21	38	2311297 (4), 15320899 (4), 8871757 (1), 12780686 (1) (see all 27)
goiter	86.16	59	7711505 (6), 7951537 (5), 15326651 (2), 7549998 (2) (see all 29)
goiter congenital	85.64	9	11916616 (2), 16042141 (1), 16649969 (1), 2096156 (1) (see all 6)

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Genatlas disease: TPO

goiter (organification defect IIA)

Human Gene Mutation Database: TPO
Genetic Association Database: TPO
Human Genome Epidemiology Navigator: TPO (41 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/861 PubMed articles for TPO gene (see all 861 ):

Partial iodide organification defect caused by a novel mutation of the thyroid peroxidase gene in three siblings. (PubMed id 12864797)^{1, 3, 4} Kotani T....Harada S. (2003)
Molecular analysis of mutated thyroid peroxidase detected in patients with total iodide organification defects. (PubMed id 9024270)^{1, 3, 4} Bikker H.... De Vijlder J.J.M. (1997)
Two decades of screening for congenital hypothyroidism in The Netherlands: TPO gene mutations in total iodide organification defects (an update). (PubMed id 11061528)^{1, 3, 4} Bakker B....De Vijlder J.J.M. (2000)
A novel mutation in the human thyroid peroxidase gene resulting in a total iodide organification defect. (PubMed id 9924196)^{1, 3, 4} Kotani T.... Ohtaki S. (1999)
Five novel inactivating mutations in the thyroid peroxidase gene responsible for congenital goiter and iodide organification defect. (PubMed id 12938097)^{1, 3, 4} Rivolta C.M.... Targovnik H.M. (2003)
Two novel missense mutations in the thyroid peroxidase gene, R665W and G771R, result in a localization defect and cause congenital hypothyroidism. (PubMed id 11916616)^{1, 3, 4} Umeki K.... Ichiba Y. (2002)
Goitrous congenital hypothyroidism and hearing impairment associated with mutations in the TPO and SLC26A4/PDS genes. (PubMed id 16684826)^{1, 3, 4} Pfarr N.... Pohlenz J. (2006)
Two novel mutations in the thyroid peroxidase gene with goitrous hypothyroidism. (PubMed id 16284446)^{1, 3, 4} Tajima T.... Fujieda K. (2005)
Identification of a novel partner of duox: EFP1, a thioredoxin- related protein. (PubMed id 15561711)^{1, 3, 4} Wang D....Miot F. (2005)
Monoallelic expression of mutant thyroid peroxidase allele causing total iodide organification defect. (PubMed id 12843174)^{1, 3, 4} Fugazzola L.... Beck-Peccoz P. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7173	HGNC: 12015	AceView: TPO	Ensembl:ENSG00000115705	euGenes: HUgn7173
ECgene: TPO	H-InvDB: TPO

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TPO	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Thyroid_peroxidase

Licensable Technologies for TPO
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TPO:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TPO-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TPO		Antibodies for TPO
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TPO		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TPO)
	Antibodies (TPO)
	Chimera RNAi (TPO)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Thyroid Peroxidase)
	Antibodies (Thyroid Peroxidase)

Search OriGene for TPO

Search Tocris compounds for TPO

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TPO

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
TPO Gene at Home site.
Version 2.41.1
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TPO Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for TPO

Summaries
for TPO

Genomic Location
for TPO

Proteins
for TPO

Protein Domains/
Families
for TPO

Gene Function
for TPO

Pathways & Interactions
for TPO

Drugs & Compounds
for TPO

Transcripts
for TPO

Expression
for TPO

Orthologs
for TPO

Paralogs
for TPO

SNPs/Variants
for TPO

Disorders & Mutations
for TPO

Medical News
for TPO

Publications
for TPO

Search for TPO

Genome Databases showing TPO

Other Databases showing TPO

Specialized Databases showing TPO

Licensable Technologies
for TPO

Services
for TPO

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TPO Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor TPO

Summariesfor TPO

Genomic Locationfor TPO

Proteinsfor TPO

Protein Domains/Familiesfor TPO

Gene Functionfor TPO

Pathways & Interactionsfor TPO

Drugs & Compoundsfor TPO

Transcriptsfor TPO

Expression for TPO

Orthologsfor TPO

Paralogsfor TPO

SNPs/Variantsfor TPO

Disorders & Mutationsfor TPO

Medical Newsfor TPO

Publicationsfor TPO

Search for TPO

Genome Databases showing TPO

Other Databases showing TPO

Specialized Databases showing TPO

Licensable Technologiesfor TPO

Servicesfor TPO

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TPO

Summaries
for TPO

Genomic Location
for TPO

Proteins
for TPO

Protein Domains/
Families
for TPO

Gene Function
for TPO

Pathways & Interactions
for TPO

Drugs & Compounds
for TPO

Transcripts
for TPO

Expression
for TPO

Orthologs
for TPO

Paralogs
for TPO

SNPs/Variants
for TPO

Disorders & Mutations
for TPO

Medical News
for TPO

Publications
for TPO

Licensable Technologies
for TPO

Services
for TPO