TPMT Gene
protein-coding GIFtS: 64
GCID: GC06M018072
|
|
thiopurine S-methyltransferase
| |
Aliases
for TPMT gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Thiopurine S-Methyltransferase1 2 | | EC 2.1.1.673 8 | | S-Adenosyl-L-Methionine:Thiopurine S-Methyltransferase2 | | Thiopurine Methyltransferase3 |
Export aliases for TPMT gene to outside databasesPrevious GC identifers: GC06M018186 GC06M018236 |
Summaries
for TPMT gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TPMT:
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor andS-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeuticagents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity andtoxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TPMT_HUMAN, P51580Function: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine
Gene Wiki entry for TPMT (Thiopurine methyltransferase)
PharmGKB "VIP" summary for
TPMT
|
Genomic Views
for TPMT gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TPMT gene promoter:
SRF Pbx1a SRF (504 AA) SEF-1 (1) POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TPMT
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPMT |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p22.3 Ensembl cytogenetic band: 6p22.3 HGNC cytogenetic band: 6p22.3TPMT Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M018072: view genomic region
(about GC identifiers)
Start:
|
18,128,542 bp from pter |
End:
|
18,155,374 bp from pter |
Size:
|
26,833 bases |
Orientation:
|
minus strand |
|
Proteins
for TPMT gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TPMT_HUMAN, P51580 (See
protein sequence)Recommended Name: Thiopurine S-methyltransferase Size: 245 amino acids; 28180 Da
Subunit: Monomer
Subcellular location: Cytoplasm
Miscellaneous: TPMT deficiency inherited by TPMT*2 and TPMT*3A alleles, are the most prevalent mutant TPMT in humans.TPMT deficiency is associated with lower cellular levels of TPMT protein, and the proteins encoded by TPMT*2 andTPMT*3A mutant alleles are degraded more rapidly by an ATP-dependent proteasome-mediated pathway
Sequence caution: Sequence=AAB71631.1; Type=Erroneous initiation; Sequence=AAB71632.1; Type=Erroneous initiation;
2 PDB 3D structures from  and Proteopedia  for TPMT:2BZG (3D)
2H11 (3D)
Secondary accessions: O14806 O15423 O15424 O15425 O15426 O15515 O15548 O43213 Q5VUK6 Q9UBE6 Q9UBT8Q9UE62Explore the universe of human proteins at neXtProt for TPMT: NX_P51580
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P51580
4/14 DME Specific Peptides for TPMT (P51580) (see all 14)
TPMT Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000358.1
ENSEMBL proteins: ENSP00000312304 Reactome Protein details: P51580
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- |
TPMT for ontologies About GeneDecksing
TPMT Antibody Products:
Assay Products for TPMT: |
Protein
Domains /
Families
for TPMT gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TPMT for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P51580ProtoNet protein and cluster: P51580 1 Blocks protein family: IPB008854 Thiopurine S-methyltransferase
UniProtKB/Swiss-Prot: TPMT_HUMAN, P51580Similarity: Belongs to the methyltransferase superfamily. TPMT family |
Function
for TPMT gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TPMT_HUMAN, P51580Function: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurineCatalytic activity: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methyletherEnzyme regulation: Inhibited by S-adenosyl-L-homocysteine (SAH)Biophysicochemical properties: Kinetic parameters: KM=5.6 mM for S-adenosyl-L-methionine; KM=0.35 mM for6-mercaptopurine; Vmax=0.6 nmol/sec/mg enzyme toward 6-mercaptopurine (at 37 degrees Celsius); Genatlas biochemistry entry for TPMT:thiopurine methyltransferase,cytosolic,catalyzing the S-methylation of thiopurine drugs
Enzyme Number (IUBMB): EC 2.1.1.671 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPMT (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPMT
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TPMT (NM_000367) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TPMT | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPMT |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPMT |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008119 | thiopurine S-methyltransferase activity |
IEA | -- |
TPMT for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Tpmttm1Rlng for TPMT
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tpmt):
TPMT for phenotypes About GeneDecksing
|
Pathways & Interactions
for TPMT gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Biological oxidations | | | 2 | Metabolism | | | 3 | Antimetabolite Pathway - Folate Cycle, Pharmacodynamics | | | 4 | Glucuronidation | | | 5 | Methionine metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for TPMT
4 
Reactome Pathways for TPMT
1  PharmGKB Pathway for TPMT
1 
Kegg Pathway (Kegg details for TPMT):
TPMT for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TPMT
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/9 Interacting proteins for TPMT (P515803 ENSP000003123044) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
TPMT for ontologies About GeneDecksing
|
Drugs & Compounds
for TPMT gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TPMT for compounds About GeneDecksing
 Browse Tocris compounds for TPMT
2 HMDB Compounds for TPMT About this table
5 DrugBank Compounds for TPMT About this table
10/51 Novoseek chemical compound relationships for TPMT gene (see all 51) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| thiopurine |
99.6 |
1711 |
11876691 (10), 8721407 (6), 15854172 (6), 8171183 (6) (see all 99) |
| 6 mercaptopurine |
97.4 |
557 |
8861653 (8), 11681411 (8), 20021291 (6), 16795981 (6) (see all 99) |
| 6-thioguanine nucleotide |
93.7 |
38 |
11856081 (3), 16633046 (3), 8721407 (2), 15167634 (2) (see all 17) |
| 6 thioguanine |
92.6 |
135 |
10954350 (5), 7603453 (4), 11479220 (4), 11037857 (4) (see all 60) |
| 6-methylthioguanine |
91.8 |
25 |
9681671 (4), 15588444 (2), 14630365 (2), 19695401 (1) (see all 6) |
| azathioprine |
91.7 |
599 |
12192200 (8), 7857117 (7), 10628931 (7), 10727309 (6) (see all 99) |
| inosine triphosphate |
91.5 |
28 |
16431304 (2), 19960028 (2), 18090994 (2), 16880012 (2) (see all 13) |
| trimethylolpropane trimethacrylate |
90.6 |
4 |
16886902 (2), 11995359 (1), 18563949 (1) |
| azathioprine |
90.3 |
190 |
20066544 (8), 15118980 (8), 19663853 (5), 18693152 (5) (see all 55) |
| 3,4-dimethoxy-5-hydroxybenzoic acid |
81.3 |
3 |
1510725 (1), 1981712 (1) |
5 PharmGKB related drug/compound annotations for TPMT geneAbout this table
Search CenterWatch for drugs/clinical trials and news about TPMT
|
Transcripts
for TPMT gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TPMT gene: NM_000367.2 Unigene Cluster for TPMT: Thiopurine S-methyltransferase Hs.444319 [show with all ESTs]Unigene Representative Sequence: NM_0003671 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000309983(uc003ncm.3 uc010jpm.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPMT (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPMT
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TPMT (NM_000367) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TPMT | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPMT |
Additional cDNA sequence: AF021876.1 AF021877.1 AK310420.1 BC005339.1 BC009596.1 S62904.1 U12387.1 9 DOTS entries: DT.40229878 DT.100794976 DT.100794972 DT.304872 DT.121390773 DT.92438220 DT.121390784 DT.121390792 DT.95290455 24/160 AceView cDNA sequences (see all 160): CB163401 BQ027068 CB154844 AA356473 AI365341 CB118654 AW591638 AW950465 AA284103 BM454559 AA825975 BM969125 U12387 BQ778222 BU726277 AA291185 CA306131 BI966707 AJ714224 CK903373 AA746081 BG170081 AW470006 BI789285
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TPMT (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c |
|---|
|
| SP1: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TPMT
|
Expression
for TPMT gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TPMT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAATTATTT
About this image
See TPMT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TPMT
SOURCE GeneReport for Unigene cluster: Hs.444319
SABiosciences Expression via Pathway-Focused PCR Arrays including TPMT:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TPMT
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TPMT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPMT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPMT | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPMT |
Orthologs
for TPMT gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TPMT gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for TPMT (if available)
TreeFam Gene Tree for TPMT (if available) |
Paralogs
for TPMT gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TPMT gene
1 SIMAP similar gene for TPMT using alignment to 2 protein entries: TPMT_HUMAN (see all proteins):pseudoTPMT
TPMT for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for TPMT
PGOHUM00000235052 PGOHUM00000237600 PGOHUM00000241300 PGOHUM00000241424
|
Genomic Variants
for TPMT gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: TPMT_HUMAN, P51580Polymorphism: Individual variation in the toxicity and therapeutic efficacy of thiopurine drugs is associated with acommon genetic polymorphism that controls levels of TPMT activity. Genetic polymorphism in the TPMT gene is such thatabout 90% of Caucasians have high TPMT activity, 10% have intermediate activity and 1 in 300 individuals has lowactivity. TPMT activity varies among ethnic groupsPolymorphism: TPMT*3A is the only mutant allele found in the South West Asians. This is also the most common mutantallele in the Caucasians but is not found in the Chinese. All mutant alleles identified in the Chinese population wereTPMT*3C. This allele is found at a low frequency in the Caucasians. This suggests that TPMT*3C is the oldest mutation,with TPMT*3B being acquired later to form the TPMT*3A allele in the Caucasian and South West Asian populations. TPMT*2appears to be a more recent allele, which has only been detected in Caucasians to date. These ethnic differences maybe important in the clinical use of thiopurine drugs
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TPMT (18128542 - 18155374 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TPMT: --
Human Gene Mutation Database (HGMD): TPMT
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPMT |
|
Disorders
/ Diseases
for TPMT gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TPMT for disorders About GeneDecksing
OMIM gene information: 187680
OMIM disorders: 610460
UniProtKB/Swiss-Prot: TPMT_HUMAN, P51580
Defects in TPMT are the cause of thiopurine S-methyltransferase deficiency (TPMT deficiency) [MIM:610460].TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used asimmunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia,autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicityafter receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response tothese drugs are largely determined by genetic variation at the TPMT locus
20/43  diseases for TPMT (see all 43): About MalaCardshomocysteine nodular regenerative hyperplasia wegener's granulomatosis invasive aspergillosis
type 2 diabetes mellitus pemphigus vulgaris gilbert syndrome inflammatory bowel disease
dyshidrosis lymphoblastic leukemia lupus erythematosus pancytopenia
multiple sclerosis systemic lupus erythematosus aspergillosis leukopenia
diabetes mellitus pemphigus hearing loss atopic dermatitis
5 diseases from the University of Copenhagen DISEASES database for TPMT:Inflammatory bowel disease Leukopenia Leukemia Pancytopenia
Autoimmune hepatitis 10/47 Novoseek disease relationships for TPMT gene (see all 47) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| inflammatory bowel diseases |
80.8 |
106 |
12812701 (5), 11876691 (5), 15352906 (3), 12021625 (3) (see all 53) |
| leukopenia |
70 |
47 |
16431304 (4), 19390192 (3), 12192200 (3), 20081263 (3) (see all 23) |
| lymphoblastic leukemia acute |
69.2 |
38 |
1960624 (3), 16886902 (2), 18987654 (1), 20021291 (1) (see all 22) |
| lymphoblastic leukemia acute childhood |
65.7 |
10 |
17164697 (2), 18987654 (1), 10764140 (1), 19535798 (1) (see all 6) |
| colitis ulcerative |
61.6 |
13 |
11927101 (3), 11007234 (2), 16795981 (2), 19217567 (1) (see all 8) |
| pancytopenia |
59.5 |
12 |
11037857 (2), 12172211 (2), 12454589 (1), 16995868 (1) (see all 6) |
| hepatitis autoimmune |
58.5 |
17 |
14588189 (3), 8551001 (2), 12217596 (2), 16876902 (2) (see all 10) |
| depression bone marrow |
55 |
6 |
17074104 (2), 9086303 (1), 18520612 (1), 20101557 (1) |
| leukemia |
50 |
35 |
19177822 (2), 16041371 (2), 15737567 (2), 11108431 (1) (see all 24) |
| neutropenia |
48.9 |
16 |
18685564 (2), 18601797 (2), 20081263 (2), 18662289 (1) (see all 10) |
Genetic Association Database (GAD): TPMT
Human Genome Epidemiology (HuGE) Navigator: TPMT (150 documents)
Export disorders for TPMT gene to outside databases
|
Publications
for TPMT gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TPMT gene, integrated from 9 sources (see all 541):
(articles sorted by number of sources associating them with TPMT) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human thiopurine methyltransferase: molecular cloning and expression of T84 colon carcinoma cell cDNA. (PubMed id 8316220)1, 2, 3, 9 Honchel R.... Weinshilboum R.M. (1993)
- Genetic analysis of thiopurine methyltransferase polymorphism in a Japanese population. (PubMed id 10751626)1, 2, 4, 9 Hiratsuka M.... Mizugaki M. (2000)
- Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism. (PubMed id 8561894)1, 2, 9 Szumlanski C.... Weinshilboum R.M. (1996)
- Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity. (PubMed id 9177237)1, 2, 9 Tai H.-L.... Evans W.E. (1997)
- Phenotyping and genotyping study of thiopurine S-methyltransferase in healthy Chinese children: a comparison of Han and Yao ethnic groups. (PubMed id 15255798)1, 4, 9 Zhang J.P....Huang M. (2004)
- Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants. (PubMed id 15226673)1, 4, 9 Schaeffeler E....Schwab M. (2004)
- Thiopurine methyltransferase (TPMT) heterozygosity and enzyme activity as predictive tests for the development of azathioprine-related adverse events. (PubMed id 15792824)1, 4, 9 Heckmann J.M....Owen E.P. (2005)
- Frequency of the thiopurine S-methyltransferase alleles in the ancient genetic population isolate of Sardinia. (PubMed id 16789994)1, 2, 9 Rossino R.... Congia M. (2006)
- Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia. (PubMed id 15784872)1, 4, 9 Stanulla M....Schwab M. (2005)
- Thiopurine methyltransferase (TPMT) genotype distribution in azathioprine-tolerant and -intolerant patients with various disorders. The impact of TPMT genotyping in predicting toxicity. (PubMed id 14634700)1, 4, 9 Reuther L.O....Larsen N.E. (2004)
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External Searches for TPMT gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing TPMT gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing TPMT gene
(According to HUGE)
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Specialized Databases showing TPMT gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for TPMT gene:
Search GeneIP for patents involving TPMT
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TPMT gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for TPMT | | OriGene shRNA RFP for TPMT | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TPMT | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TPMT | | | OriGene Protein Over-expression Lysate for TPMT | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TPMT | | OriGene 3'-UTR Clone for TPMT | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPMT | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPMT | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TPMT | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TPMT | | OriGene Custom Protein Services for TPMT | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TPMT | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPMT | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPMT | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TPMT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPMT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPMT |
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| | | | Search Tocris compounds for TPMT |
| |  |  |  |  | | | | | | Recombinant Protein for TPMT |
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 | | | TPMT Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPMT |
|  |  |  | | | | Search ThermoFisher Antibodies for TPMT |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPMT |
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