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TPM4 Gene

protein-coding   GIFtS: 65
GCID: GC19P017852

Tropomyosin 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tropomyosin 41 2     Tropomyosin Alpha-4 Chain2
TM30p12 3     tropomyosin-42
HEL-S-1082     Tropomyosin-43
Epididymis Secretory Protein Li 1082     

External Ids:    HGNC: 120131   Entrez Gene: 71712   Ensembl: ENSG000001674607   OMIM: 6003175   UniProtKB: P679363   

Export aliases for TPM4 gene to outside databases

Previous GC identifers: GC19P016682 GC19P016571 GC19P016023 GC19P016048 GC19P016039 GC19P016178 GC19P015749 GC19P017060 GC19P017322


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TPM4 Gene:
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system
of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil
proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the
filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction
by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Nov 2009)

GeneCards Summary for TPM4 Gene:
TPM4 (tropomyosin 4) is a protein-coding gene. Diseases associated with TPM4 include inflammatory myofibroblastic tumor, and vaginal cancer. GO annotations related to this gene include structural constituent of muscle and calcium ion binding. An important paralog of this gene is TPM3.

UniProtKB/Swiss-Prot: TPM4_HUMAN, P67936
Function: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the
troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle
contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing
cytoskeleton actin filaments. Binds calcium

Gene Wiki entry for TPM4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TPM4 gene promoter:
         CHOP-10   CREB   MZF-1   ARP-1   AP-4   Roaz   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): TPM4 promoter sequence
   Search Chromatin IP Primers for TPM4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.1

TPM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPM4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P017852:  view genomic region     (about GC identifiers)

Start:
16,177,831 bp from pter      End:
16,213,813 bp from pter
Size:
35,983 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TPM4_HUMAN, P67936 (See protein sequence)
Recommended Name: Tropomyosin alpha-4 chain  
Size: 248 amino acids; 28522 Da
Subunit: Heterodimer of an alpha and a beta chain (By similarity)
Secondary accessions: P07226 Q15659 Q5U0D9 Q9BU85 Q9H8Q3 Q9UCS1 Q9UCS2 Q9UCS3 Q9UCS4
Alternative splicing: 2 isoforms:  P67936-1, P07226-1   P67936-2, P07226-2   

Explore the universe of human proteins at neXtProt for TPM4: NX_P67936

Explore proteomics data for TPM4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys11, Lys13, Lys132, Lys169, Lys190, Lys228
  • Modification sites at PhosphoSitePlus

  • See TPM4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138632.1  NP_003281.1  

    ENSEMBL proteins: 
     ENSP00000466158   ENSP00000345230   ENSP00000468246   ENSP00000467087   ENSP00000467558  
     ENSP00000300933   ENSP00000467250   ENSP00000466106   ENSP00000466654   ENSP00000467319  
     ENSP00000468010   ENSP00000439135  
    Reactome Protein details: P67936

    TPM4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TPM: Tropomyosins

    1 InterPro protein domain:
     IPR000533 Tropomyosin

    Graphical View of Domain Structure for InterPro Entry P67936

    ProtoNet protein and cluster: P67936

    UniProtKB/Swiss-Prot: TPM4_HUMAN, P67936
    Domain: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a
    prominent seven-residues periodicity
    Similarity: Belongs to the tropomyosin family


    TPM4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TPM4_HUMAN, P67936
    Function: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the
    troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle
    contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing
    cytoskeleton actin filaments. Binds calcium

         Genatlas biochemistry entry for TPM4:
    tropomyosin 4,alpha,skeletal muscle and non muscle isoforms,dimerizing to form a helical coiled coil binding to
    actin in the troponin complex (thin filamant) that regulates calcium-dependent binding of actin and myosin and
    muscle contraction

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005509calcium ion binding NAS1836432
    GO:0008307structural constituent of muscle TAS8641132
         
    TPM4 for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target TPM4:
    hsa-mir-28-5p (MIRT049990), hsa-mir-1 (MIRT002782), hsa-mir-215-5p (MIRT024410), hsa-mir-125a-5p (MIRT045744), hsa-mir-940 (MIRT036591), hsa-mir-192-5p (MIRT026576), hsa-let-7b-5p (MIRT052131)

    Block miRNA regulation of human, mouse, rat TPM4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TPM4 (see all 64):
    hsa-miR-411* hsa-miR-582-3p hsa-miR-26a-2* hsa-miR-379* hsa-miR-24-1* hsa-miR-25 hsa-miR-605 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidTPM4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TPM4

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    GenScript: all cDNA clones in your preferred vector (see all 2): TPM4 (NM_003290)
    Sino Biological Human cDNA Clone for TPM4
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPM4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPM4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TPM4_HUMAN, P67936: Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IDA16236705
    GO:0002102podosome IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton TAS16130169

    TPM4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TPM4 About    
    See pathways by source

    SuperPathContained pathways About
    1Striated Muscle Contraction
    Striated Muscle Contraction0.82
    Muscle contraction0.61
    Striated Muscle Contraction0.82
    Smooth Muscle Contraction0.47
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Dilated cardiomyopathy0.75
    3Cardiac muscle contraction
    Cardiac muscle contraction
    4Adrenergic signaling in cardiomyocytes
    Adrenergic signaling in cardiomyocytes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TPM4
        Striated Muscle Contraction


    2 Reactome Pathways for TPM4
        Smooth Muscle Contraction
    Striated Muscle Contraction


    4 Kegg Pathways  (Kegg details for TPM4):
        Cardiac muscle contraction
    Adrenergic signaling in cardiomyocytes
    Hypertrophic cardiomyopathy (HCM)
    Dilated cardiomyopathy


    TPM4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including TPM4: 
              Osmotic Stress in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TPM4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TPM4 (P679363 ENSP000003452304) via UniProtKB, MINT, STRING, and/or I2D (see all 153)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIP6Q156543, ENSP000002004574I2D: score=2 STRING: ENSP00000200457
    TCERG1O147763, ENSP000002967024I2D: score=2 STRING: ENSP00000296702
    PACSIN1Q9BY113, ENSP000002444584I2D: score=3 STRING: ENSP00000244458
    APCP250543I2D: score=2 
    ARRB1P494073I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS16130169
    GO:0006936muscle contraction TAS--
    GO:0030049muscle filament sliding TAS--

    TPM4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TPM4

    1 HMDB Compound for TPM4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TPM4 gene (2 alternative transcripts): 
    NM_001145160.1  NM_003290.2  

    Unigene Cluster for TPM4:

    Tropomyosin 4
    Hs.631618  [show with all ESTs]
    Unigene Representative Sequence: AK056565
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589897 ENST00000344824(uc002ndi.2) ENST00000586499 ENST00000586833
    ENST00000588507 ENST00000300933(uc002ndj.2) ENST00000587201 ENST00000588410
    ENST00000590180 ENST00000588483 ENST00000592138 ENST00000588032 ENST00000586193
    ENST00000591645 ENST00000592822 ENST00000591226 ENST00000538887(uc002ndk.1)

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    Selected qRT-PCR Assays for microRNAs that regulate TPM4 (see all 64):
    hsa-miR-411* hsa-miR-582-3p hsa-miR-26a-2* hsa-miR-379* hsa-miR-24-1* hsa-miR-25 hsa-miR-605 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidTPM4 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for TPM4
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TPM4
      QuantiTect SYBR Green Assays in human, mouse, rat TPM4
      QuantiFast Probe-based Assays in human, mouse, rat TPM4

    Additional mRNA sequence: 

    AF186109.1 AK023385.1 AK056565.1 AK095546.1 AK125191.1 AK300136.1 AK301285.1 AK307538.1 
    AK315076.1 BC002827.2 BC037576.1 BC067225.1 BT019634.1 M12127.1 X05276.1 Z36778.1 

    Selected DOTS entries (see all 34):

    DT.97866054  DT.70101123  DT.97870025  DT.97821601  DT.95346341  DT.99990532  DT.95252375  DT.121478976 
    DT.100893663  DT.97870006  DT.75194236  DT.100893658  DT.121478979  DT.121478983  DT.121479013  DT.121479040 
    DT.86842758  DT.86992837  DT.92470231  DT.100035474  DT.121478963  DT.121479036  DT.91909262  DT.95297600 

    Selected AceView cDNA sequences (see all 460):

    AA096433 AW361062 BQ706675 AI744235 CA392344 BF915912 BE073620 BQ228444 
    BG757280 AW173716 BF835526 BQ898783 AA853762 AU280448 BM918103 CB159522 
    BE393287 AI245925 AI087249 BQ438234 BP338944 BM875323 AA639664 BM848731 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TPM4 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
    SP1:                    -                 -     -     -     -                                   -                                       
    SP2:                                            -     -     -                                   -                                       
    SP3:                                                        -                                                                           
    SP4:                                                                                            -                                       
    SP5:                                            -     -     -                                                                           


    ECgene alternative splicing isoforms for TPM4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TPM4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCTACTAA
    TPM4 Expression
    About this image


    TPM4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 14 entries
             Multinuclear Myocytes Lumbar Back Muscles
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Multinuclear Myocytes Forelimb Dorsal Muscles
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Trophoblast Cells Trophoblast
    TPM4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TPM4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631618

    UniProtKB/Swiss-Prot: TPM4_HUMAN, P67936
    Tissue specificity: Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher
    molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive
    patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at
    protein level)

        Pathway & Disease-focused RT2 Profiler PCR Array including TPM4: 
              Osmotic Stress in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat TPM4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPM4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TPM4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tpm45 tropomyosin 4   --   8 (34.81 cM) 72134975 
    chicken
    (Gallus gallus)
    Aves TPM46
    tropomyosin 4
    88(a)
    1 ↔ 1
    28(4195685-4203208)
    lizard
    (Anolis carolinensis)
    Reptilia TPM46
    tropomyosin 4
    92(a)
    1 ↔ 1
    AAWZ02041359(21-5530)
    African clawed frog
    (Xenopus laevis)
    Amphibia L35238.12   -- 80.05(n)    L35238.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC053144.12   -- 75.95(n)    BC053144.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tm26
    Tm16
    Tropomyosin 1
    46(a)
    21(a)
    many ↔ many
    many ↔ many
    3R(11135915-11140919)
    3R(11107093-11134501)
    worm
    (Caenorhabditis elegans)
    Secernentea lev-116
    Protein LEV-11, isoform e
    56(a)
    1 → many
    I(14620759-14631254) WBGene00002978


    ENSEMBL Gene Tree for TPM4 (if available)
    TreeFam Gene Tree for TPM4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TPM4 gene
    TPM32  TPM12  TPM22  
    8 SIMAP similar genes for TPM4 using alignment to 10 protein entries:     TPM4_HUMAN (see all proteins):
    TPM1    TPM2    TPM3    HEL-S-82p    TPM3-ROS1    TPM2b
    OK/SW-cl.5    DKFZp686J1372

    TPM4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TPM4 (see all 907)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365354
    A breast cancer sample4--see VAR_0365352 E Q mis40--------
    rs104248151,2
    C,F,A,H--16108607(+) GCTTTT/AGTCAC 1 -- us2k18Minor allele frequency- A:0.28NS EA NA WA 780
    rs1393856961,2
    --16108633(+) GTGTAA/GCATGG 1 -- us2k10--------
    rs781423041,2
    C,F--16108657(+) TAAGGG/AAGGAG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1496421911,2
    --16108673(+) AGAACA/GGAGTT 1 -- us2k10--------
    rs48084491,2
    C,F,A,H--16108685(+) GGGAGG/CGGTCT 1 -- us2k1 tfbs38Minor allele frequency- C:0.25NA WA EA 368
    rs1813671761,2
    --16108742(+) TTAGCA/GCATGA 1 -- us2k10--------
    rs1837491691,2
    --16108797(+) ACCAAC/TAGGGG 1 -- us2k10--------
    rs1881294511,2
    --16109076(+) GAGGAA/GGAGCC 1 -- us2k10--------
    rs81103251,2
    C,F,A,H--16109227(+) CACAGA/GCAAGA 1 -- us2k124Minor allele frequency- G:0.21NS EA NA WA 2766

    HapMap Linkage Disequilibrium report for TPM4 (16177831 - 16213813 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TPM4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718258CNV Deletion23290073
    nsv911157CNV Loss21882294
    nsv137994CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TPM4
    DNA2.0 Custom Variant and Variant Library Synthesis for TPM4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600317    OMIM disorders: --

    20 diseases for TPM4:    
    About MalaCards
    inflammatory myofibroblastic tumor    vaginal cancer    vaginitis    hypertrophic cardiomyopathy
    familial hypertrophic cardiomyopathy    anaplastic large cell lymphoma    esophageal cancer    dilated cardiomyopathy
    esophageal squamous cell carcinoma    esophagitis    breast and colorectal cancer    squamous cell carcinoma
    hypertension    schizophrenia    lung cancer    cervicitis
    endotheliitis    thyroiditis    colorectal cancer    cerebritis

    1 disease from the University of Copenhagen DISEASES database for TPM4:
    Anaplastic large cell lymphoma

    TPM4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TPM4

    Export disorders for TPM4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TPM4 gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with TPM4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans. (PubMed id 22423221)1, 4 Qayyum R....Reiner A.P. (PLoS Genet. 2012)
    2. New gene functions in megakaryopoiesis and platelet formation. (PubMed id 22139419)1, 4 Gieger C....Soranzo N. (Nature 2011)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    6. Assignment of the human alpha-tropomyosin gene TPM4 to band 19p13.1 by fluorescence in situ hybridization. (PubMed id 8641132)1, 3 Wilton S.D....Laing N.G. (Cytogenet. Cell Genet. 1996)
    7. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (Electrophoresis 1992)
    8. The calcium binding protein tropomyosin in human platelets and cardiac tissue: elevation in hypertensive cardiac hypertrophy. (PubMed id 1836432)1, 2 Crabos M....Erne P. (Eur. J. Clin. Invest. 1991)
    9. Characterization of a cDNA defining a gene family encoding TM30p1, a human fibroblast tropomyosin. (PubMed id 3612796)1, 2 McLeod A.R.... Houlker C. (J. Mol. Biol. 1987)
    10. A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism. (PubMed id 3865200)1, 2 MacLeod A.R.... Walsh F.S. (Proc. Natl. Acad. Sci. U.S.A. 1985)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7171 HGNC: 12013 AceView: TPM4 Ensembl:ENSG00000167460 euGenes: HUgn7171
    ECgene: TPM4 Kegg: 7171 H-InvDB: TPM4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TPM4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TPM4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TPM4 gene:
    Search GeneIP for patents involving TPM4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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