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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TPM4 Gene

protein-coding   GIFtS: 61
GCID: GC19P017060

tropomyosin 4
 Explore 13 diseases affiliated with
TPM4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TPM4    

Aliases
for TPM4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tropomyosin 41 2
TM30p12 3
Tropomyosin Alpha-4 Chain2
Tropomyosin-43
Tropomyosin-43

External Ids:    HGNC: 120131   Entrez Gene: 71712   Ensembl: ENSG000001674607   OMIM: 6003175   UniProtKB: P679363   

Export aliases for TPM4 gene to outside databases

Previous GC identifers: GC19P016682 GC19P016571 GC19P016023 GC19P016048 GC19P016039 GC19P016178 GC19P015749


Summaries
for TPM4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TPM4:
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of
striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins
that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and
regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the
binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Nov 2009)

UniProtKB/Swiss-Prot: TPM4_HUMAN, P67936
Function: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the
troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle
contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton
actin filaments. Binds calcium

Gene Wiki entry for TPM4


Genomic Views
for TPM4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TPM4 gene promoter:
         CHOP-10   CREB   MZF-1   ARP-1   AP-4   Roaz   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): TPM4 promoter sequence
   Search SABiosciences Chromatin IP Primers for TPM4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.1

TPM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPM4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P017060:  view genomic region     (about GC identifiers)

Start:
 16,177,831 bp from pter      End:
 16,213,813 bp from pter
Size:
 35,983 bases      Orientation:
 plus strand

Proteins
for TPM4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TPM4_HUMAN, P67936 (See protein sequence)
Recommended Name: Tropomyosin alpha-4 chain  
Size: 248 amino acids; 28522 Da
Subunit: Heterodimer of an alpha and a beta chain (By similarity)
Subcellular location: Cytoplasm, cytoskeleton
Secondary accessions: P07226 Q15659 Q5U0D9 Q9BU85 Q9H8Q3 Q9UCS1 Q9UCS2 Q9UCS3 Q9UCS4
Alternative splicing: 2 isoforms:  P67936-1, P07226-1   P67936-2, P07226-2   

Explore the universe of human proteins at neXtProt for TPM4: NX_P67936

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P67936

    • TPM4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138632.1  NP_003281.1  

    ENSEMBL proteins: 
     ENSP00000466158   ENSP00000345230   ENSP00000468246   ENSP00000467087   ENSP00000467558  
     ENSP00000300933   ENSP00000467250   ENSP00000466106   ENSP00000466654   ENSP00000467319  
     ENSP00000468010   ENSP00000439135  
    Reactome Protein details: P67936
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: TPM4
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    Novus Biologicals TPM4 Proteins
    Novus Biologicals TPM4 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for TPM4
    Uscn Proteins for TPM4

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IDA16236705
    GO:0002102podosome IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton TAS16130169


    TPM4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TPM4

    Protein Domains /
    Families
    for TPM4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TPM4 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000533 Tropomyosin

    Graphical View of Domain Structure for InterPro Entry P67936

    ProtoNet protein and cluster: P67936

    UniProtKB/Swiss-Prot: TPM4_HUMAN, P67936
    Domain: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a
    prominent seven-residues periodicity
    Similarity: Belongs to the tropomyosin family


    Function
    for TPM4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TPM4_HUMAN, P67936
    Function: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the
    troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle
    contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton
    actin filaments. Binds calcium

         Genatlas biochemistry entry for TPM4:
    tropomyosin 4,alpha,skeletal muscle and non muscle isoforms,dimerizing to form a helical coiled coil binding to actin
    in the troponin complex (thin filamant) that regulates calcium-dependent binding of actin and myosin and muscle
    contraction

    miRNA
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    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate TPM4 (see all 64):
    hsa-miR-411* hsa-miR-582-3p hsa-miR-26a-2* hsa-miR-379* hsa-miR-24-1* hsa-miR-25 hsa-miR-605 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmid: TPM4 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005509calcium ion binding NAS1836432
    GO:0008307structural constituent of muscle TAS8641132


    TPM4 for ontologies           About GeneDecksing



    Pathways & Interactions
    for TPM4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Striated Muscle Contraction
    		Striated Muscle Contraction1.00
    		Muscle contraction0.65
    		Striated Muscle Contraction0.87
    		Smooth Muscle Contraction0.11
    2Hypertrophic cardiomyopathy (HCM)
    		Hypertrophic cardiomyopathy (HCM)1.00
    		Dilated cardiomyopathy0.75
    3Cardiac muscle contraction
    		Cardiac muscle contraction1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for TPM4 
        Striated Muscle Contraction

    3        Reactome Pathways for TPM4
        Smooth Muscle Contraction
    Muscle contraction
    Striated Muscle Contraction


    3         Kegg Pathways  (Kegg details for TPM4):
        Cardiac muscle contraction
    Hypertrophic cardiomyopathy (HCM)
    Dilated cardiomyopathy


    TPM4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TPM4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/101 Interacting proteins for TPM4 (P679363 ENSP000003452304) via UniProtKB, MINT, STRING, and/or I2D (see all 101)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIP6Q156543, ENSP000002004574I2D: score=2 STRING: ENSP00000200457
    TCERG1O147763, ENSP000002967024I2D: score=2 STRING: ENSP00000296702
    PACSIN1Q9BY113, ENSP000002444584I2D: score=3 STRING: ENSP00000244458
    APCP250543I2D: score=2 
    ARRB1P494073I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS16130169
    GO:0006936muscle contraction TAS--
    GO:0006979response to oxidative stress IEP16551573
    GO:0030049muscle filament sliding TAS--


    TPM4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TPM4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TPM4

    1 HMDB Compound for TPM4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about TPM4 

    Transcripts
    for TPM4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TPM4 gene (2 alternative transcripts): 
    NM_001145160.1  NM_003290.2  

    Unigene Cluster for TPM4:

    Tropomyosin 4
    Hs.631618  [show with all ESTs]
    Unigene Representative Sequence: AK056565
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589897 ENST00000344824(uc002ndi.2) ENST00000586499 ENST00000586833
    ENST00000588507 ENST00000300933(uc002ndj.2) ENST00000587201 ENST00000588410
    ENST00000590180 ENST00000588483 ENST00000592138 ENST00000588032 ENST00000586193
    ENST00000591645 ENST00000592822 ENST00000591226 ENST00000538887(uc002ndk.1)


    miRNA
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    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate TPM4 (see all 64):
    hsa-miR-411* hsa-miR-582-3p hsa-miR-26a-2* hsa-miR-379* hsa-miR-24-1* hsa-miR-25 hsa-miR-605 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmid: TPM4 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF186109.1 AK023385.1 AK056565.1 AK095546.1 AK125191.1 AK300136.1 AK301285.1 AK307538.1 
    AK315076.1 BC002827.2 BC037576.1 BC067225.1 BT019634.1 M12127.1 X05276.1 Z36778.1 

    24/36 DOTS entries (see all 36):

    DT.97866054  DT.70101123  DT.97870025  DT.97821601  DT.95346341  DT.99990532  DT.95252375  DT.121478976 
    DT.100893663  DT.97870006  DT.75194236  DT.100893658  DT.121478979  DT.121478983  DT.121479013  DT.121479040 
    DT.86842758  DT.86992837  DT.92470231  DT.100035474  DT.121478963  DT.121479036  DT.91909262  DT.92045343 

    24/460 AceView cDNA sequences (see all 460):

    AA043959 BE073620 BQ214144 BQ706675 BQ898783 AW511633 AI744235 BC037576 
    BM875323 BF770022 CA392344 BQ438234 AW580721 BQ420588 AA096433 T28637 
    BF326057 BU947634 BP354710 AI587345 BM820916 BM464266 CB135860 BQ712716 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TPM4 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
    SP1:                    -                 -     -     -     -                                   -                                       
    SP2:                                            -     -     -                                   -                                       
    SP3:                                                        -                                                                           
    SP4:                                                                                            -                                       
    SP5:                                            -     -     -                                                                           


    ECgene alternative splicing isoforms for TPM4

    Expression
    for TPM4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TPM4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTCTACTAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TPM4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/16 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 16) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb Dorsal MusclesMultinuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMultinuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMultinuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleAnterior Neck MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleCervical Back MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleLumbar Back MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleLumbar Vertebrae Column MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MusclePelvic MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MusclePosterior Neck MusclesMultinuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TPM4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TPM4

    SOURCE GeneReport for Unigene cluster: Hs.631618

    UniProtKB/Swiss-Prot: TPM4_HUMAN, P67936
    Tissue specificity: Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular
    weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with
    cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Array including TPM4: 
              Osmotic Stress in human mouse rat

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    In Situ
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    Orthologs
    for TPM4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TPM4 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tpm45 tropomyosin 4   --   8 (34.81 cM) 72134975 
    lizard
    (Anolis carolinensis)    		 Reptilia TPM16
    TPM36
    		 --
    		 60(a)
    59(a)
    		 possible ortholog
    possible ortholog
    		 AAWZ02037793(3041-7823)
    GL344238.1(6337-9084)
    African clawed frog
    (Xenopus laevis)    		 Amphibia L35238.12   -- 80.05(n)    L35238.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC053144.12   -- 75.95(n)    BC053144.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Tm26
    Tm16
    		 Tropomyosin 1
    		 45(a)
    19(a)
    		 possible ortholog
    possible ortholog
    		 3R(11135915-11140919)
    3R(11107093-11134501)
    worm
    (Caenorhabditis elegans)    		 Secernentea lev-116
    		 Tropomyosin isoforms a/b/d/f
    		 55(a)
    		 possible ortholog
    		 I(14620748-14631243)


    ENSEMBL Gene Tree for TPM4 (if available)
    TreeFam Gene Tree for TPM4 (if available) 

    Paralogs
    for TPM4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TPM4 gene
    TPM32  TPM12  TPM22  
    6 SIMAP similar genes for TPM4 using alignment to 10 protein entries:     TPM4_HUMAN (see all proteins):
    TPM1    TPM2    TPM3    TPM2b    OK/SW-cl.5    DKFZp686J1372

    TPM4 for paralogs           About GeneDecksing



    Genomic Variants
    for TPM4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/746 NCBI SNPs in TPM4 are shown (see all 746)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs104248151,2
    		C,F,A,H,--16176324(+) GCTTTT/AGTCAC 1 -- us2k18Minor allele frequency- A:0.28NS EA NA WA 780
    rs1393856961,2
    		--16176350(+) GTGTAA/GCATGG 1 -- us2k10--------
    rs781423041,2
    		F,--16176374(+) TAAGGG/AAGGAG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1496421911,2
    		--16176390(+) AGAACA/GGAGTT 1 -- us2k10--------
    rs48084491,2
    		C,F,A,H,--16176402(+) GGGAGG/CGGTCT 1 -- us2k1 tfbs38Minor allele frequency- C:0.25NA WA EA 368
    rs1813671761,2
    		--16176459(+) TTAGCA/GCATGA 1 -- us2k10--------
    rs1837491691,2
    		--16176514(+) ACCAAC/TAGGGG 1 -- us2k10--------
    rs1881294511,2
    		--16176793(+) GAGGAA/GGAGCC 1 -- us2k10--------
    rs81103251,2
    		C,F,A,H,--16176940(+) CACAGA/GCAAGA 1 -- us2k124Minor allele frequency- G:0.21NS EA NA WA 2766
    rs1809177071,2
    		--16177024(+) GCTCCC/TACATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TPM4 (16177831 - 16213813 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TPM4
         1 CNV: 5942

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for TPM4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TPM4 for disorders           About GeneDecksing

    OMIM gene information: 600317    OMIM disorders: --

    13 diseases for TPM4:    About MalaCards
    inflammatory myofibroblastic tumor    hypertrophic cardiomyopathy    familial hypertrophic cardiomyopathy    esophageal squamous cell carcinoma
    squamous cell carcinoma    cardiomyopathy    vaginal cancer    esophagitis
    vaginitis    esophageal cancer    hypertension    carcinoma
    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for TPM4:
    Anaplastic large cell lymphoma

    Export disorders for TPM4 gene to outside databases

    Publications
    for TPM4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TPM4 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with TPM4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    4. Assignment of the human alpha-tropomyosin gene TPM4 to band 19p13.1 by fluorescence in situ hybridization. (PubMed id 8641132)1, 3 Wilton S.D....Laing N.G. (1996)
    5. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (1992)
    6. The calcium binding protein tropomyosin in human platelets and cardiac tissue: elevation in hypertensive cardiac hypertrophy. (PubMed id 1836432)1, 2 Crabos M....Erne P. (1991)
    7. Characterization of a cDNA defining a gene family encoding TM30p1, a human fibroblast tropomyosin. (PubMed id 3612796)1, 2 McLeod A.R.... Houlker C. (1987)
    8. A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism. (PubMed id 3865200)1, 2 MacLeod A.R.... Walsh F.S. (1985)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Sp1 phosphorylation by cyclin-dependent kinase 1/cycli n B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)1 Chuang J.Y....Hung J.J. (2012)

    External Searches for TPM4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TPM4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7171 HGNC: 12013 AceView: TPM4 Ensembl:ENSG00000167460 euGenes: HUgn7171
    ECgene: TPM4 Kegg: 7171 H-InvDB: TPM4

    Other Databases showing TPM4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TPM4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TPM4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TPM4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TPM4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TPM4 gene:
    Search GeneIP for patents involving TPM4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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