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Aliases for TPM4 Gene

Aliases for TPM4 Gene

  • Tropomyosin 4 2 3
  • Tropomyosin-4 3 4
  • TM30p1 3 4
  • Epididymis Secretory Protein Li 108 3
  • Tropomyosin Alpha-4 Chain 3
  • HEL-S-108 3

External Ids for TPM4 Gene

Summaries for TPM4 Gene

Entrez Gene Summary for TPM4 Gene

  • This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

GeneCards Summary for TPM4 Gene

TPM4 (Tropomyosin 4) is a Protein Coding gene. Diseases associated with TPM4 include inflammatory myofibroblastic tumor. Among its related pathways are Adrenergic signaling in cardiomyocytes and Cardiac muscle contraction. GO annotations related to this gene include calcium ion binding and structural constituent of muscle. An important paralog of this gene is TPM2.

UniProtKB/Swiss-Prot for TPM4 Gene

  • Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.

Gene Wiki entry for TPM4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPM4 Gene

Genomics for TPM4 Gene

Genomic Location for TPM4 Gene

Start:
16,067,021 bp from pter
End:
16,103,005 bp from pter
Size:
35,985 bases
Orientation:
Plus strand

Genomic View for TPM4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPM4 Gene

Regulatory Elements for TPM4 Gene

Proteins for TPM4 Gene

  • Protein details for TPM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P67936-TPM4_HUMAN
    Recommended name:
    Tropomyosin alpha-4 chain
    Protein Accession:
    P67936
    Secondary Accessions:
    • P07226
    • Q15659
    • Q5U0D9
    • Q9BU85
    • Q9H8Q3
    • Q9UCS1
    • Q9UCS2
    • Q9UCS3
    • Q9UCS4

    Protein attributes for TPM4 Gene

    Size:
    248 amino acids
    Molecular mass:
    28522 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta chain.

    Alternative splice isoforms for TPM4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPM4 Gene

Proteomics data for TPM4 Gene at MOPED

Post-translational modifications for TPM4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys11, Lys13, Lys132, Lys169, Lys190, and Lys228

No data available for DME Specific Peptides for TPM4 Gene

Domains for TPM4 Gene

Gene Families for TPM4 Gene

HGNC:
  • TPM :Tropomyosins

Protein Domains for TPM4 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TPM4_HUMAN
Domain:
  • The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity:
    • P67936
Family:
  • Belongs to the tropomyosin family.:
    • P67936
genes like me logo Genes that share domains with TPM4: view

Function for TPM4 Gene

Molecular function for TPM4 Gene

GENATLAS Biochemistry: tropomyosin 4,alpha,skeletal muscle and non muscle isoforms,dimerizing to form a helical coiled coil binding to actin in the troponin complex (thin filamant) that regulates calcium-dependent binding of actin and myosin and muscle contraction
UniProtKB/Swiss-Prot Function: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.

Gene Ontology (GO) - Molecular Function for TPM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005509 calcium ion binding NAS 1836432
GO:0005515 protein binding IPI 24407287
GO:0008307 structural constituent of muscle TAS 8641132
genes like me logo Genes that share ontologies with TPM4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TPM4 Gene

Localization for TPM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPM4 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPM4 Gene COMPARTMENTS Subcellular localization image for TPM4 gene
Compartment Confidence
cytoskeleton 5
cytosol 4

Gene Ontology (GO) - Cellular Components for TPM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 16236705
GO:0002102 podosome IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton TAS 16130169
genes like me logo Genes that share ontologies with TPM4: view

Pathways for TPM4 Gene

genes like me logo Genes that share pathways with TPM4: view

Gene Ontology (GO) - Biological Process for TPM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006928 movement of cell or subcellular component TAS 16130169
GO:0006936 muscle contraction TAS --
GO:0030049 muscle filament sliding TAS --
genes like me logo Genes that share ontologies with TPM4: view

Compounds for TPM4 Gene

(1) HMDB Compounds for TPM4 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with TPM4: view

Transcripts for TPM4 Gene

Unigene Clusters for TPM4 Gene

Tropomyosin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPM4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - - - -
SP2: - - - -
SP3: -
SP4: -
SP5: - - -
SP6: - - - -
SP7: -

Relevant External Links for TPM4 Gene

GeneLoc Exon Structure for
TPM4
ECgene alternative splicing isoforms for
TPM4

Expression for TPM4 Gene

mRNA expression in normal human tissues for TPM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPM4 Gene

SOURCE GeneReport for Unigene cluster for TPM4 Gene Hs.631618

mRNA Expression by UniProt/SwissProt for TPM4 Gene

P67936-TPM4_HUMAN
Tissue specificity: Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level).
genes like me logo Genes that share expressions with TPM4: view

Orthologs for TPM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPM4 37
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TPM4 36
  • 93.78 (n)
  • 98.59 (a)
TPM4 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPM4 36
  • 92.72 (n)
  • 98.94 (a)
TPM4 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tpm4 16
Tpm4 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TPM4 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TPM4 37
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves TPM4 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TPM4 37
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.568 36
zebrafish
(Danio rerio)
Actinopterygii tpm4a 36
  • 76.64 (n)
  • 84.86 (a)
tpm4b 37
  • 78 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Tm1 37
  • 21 (a)
ManyToMany
Tm2 37
  • 46 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lev-11 37
  • 56 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10371 37
  • 63 (a)
ManyToMany
CSA.11015 37
  • 69 (a)
ManyToMany
Species with no ortholog for TPM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPM4 Gene

ENSEMBL:
Gene Tree for TPM4 (if available)
TreeFam:
Gene Tree for TPM4 (if available)

Paralogs for TPM4 Gene

Paralogs for TPM4 Gene

genes like me logo Genes that share paralogs with TPM4: view

Variants for TPM4 Gene

Sequence variations from dbSNP and Humsavar for TPM4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs745811 -- 16,073,242(-) TGACA(G/T)CATGG intron-variant
rs998316 -- 16,066,408(+) AGAAC(A/G)GAGGC upstream-variant-2KB
rs1055886 -- 16,078,773(+) CTTTC(C/G)GTCTG intron-variant
rs1076021 -- 16,076,493(+) CGCGG(C/T)TGTGC intron-variant, utr-variant-5-prime
rs1143209 -- 16,102,082(+) gcgtt(G/T)gcttt utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TPM4 Gene

Variant ID Type Subtype PubMed ID
nsv911157 CNV Loss 21882294
nsv137994 CNV Loss 16902084
esv2718258 CNV Deletion 23290073

Relevant External Links for TPM4 Gene

HapMap Linkage Disequilibrium report
TPM4

Disorders for TPM4 Gene

(1) University of Copenhagen DISEASES for TPM4 Gene

Relevant External Links for TPM4

Genetic Association Database (GAD)
TPM4
genes like me logo Genes that share disorders with TPM4: view

No data available for UniProtKB/Swiss-Prot for TPM4 Gene

Publications for TPM4 Gene

  1. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PMID: 1286667) Rasmussen H.H. … Vandekerckhove J. (Electrophoresis 1992) 3 4
  2. The calcium binding protein tropomyosin in human platelets and cardiac tissue: elevation in hypertensive cardiac hypertrophy. (PMID: 1836432) Crabos M. … Erne P. (Eur. J. Clin. Invest. 1991) 3 4
  3. Characterization of a cDNA defining a gene family encoding TM30p1, a human fibroblast tropomyosin. (PMID: 3612796) McLeod A.R. … Houlker C. (J. Mol. Biol. 1987) 3 4
  4. A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism. (PMID: 3865200) MacLeod A.R. … Walsh F.S. (Proc. Natl. Acad. Sci. U.S.A. 1985) 3 4
  5. Assignment of the human alpha-tropomyosin gene TPM4 to band 19p13.1 by fluorescence in situ hybridization. (PMID: 8641132) Wilton S.D. … Laing N.G. (Cytogenet. Cell Genet. 1996) 2 3

Products for TPM4 Gene

Sources for TPM4 Gene

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