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Aliases for TPM4 Gene

Aliases for TPM4 Gene

  • Tropomyosin 4 2 3 5
  • Tropomyosin-4 3 4
  • TM30p1 3 4
  • Epididymis Secretory Protein Li 108 3
  • HEL-S-108 3

External Ids for TPM4 Gene

Previous GeneCards Identifiers for TPM4 Gene

  • GC19P016682
  • GC19P016571
  • GC19P016023
  • GC19P016048
  • GC19P016039
  • GC19P016178
  • GC19P015749
  • GC19P017060
  • GC19P017322
  • GC19P017852
  • GC19P016069
  • GC19P016765

Summaries for TPM4 Gene

Entrez Gene Summary for TPM4 Gene

  • This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

GeneCards Summary for TPM4 Gene

TPM4 (Tropomyosin 4) is a Protein Coding gene. Diseases associated with TPM4 include inflammatory myofibroblastic tumor. Among its related pathways are Cardiac conduction and Hypertrophic cardiomyopathy (HCM). GO annotations related to this gene include calcium ion binding and structural constituent of muscle. An important paralog of this gene is TPM2.

UniProtKB/Swiss-Prot for TPM4 Gene

  • Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.

Gene Wiki entry for TPM4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPM4 Gene

Genomics for TPM4 Gene

Regulatory Elements for TPM4 Gene

Promoters for TPM4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TPM4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TPM4 Gene

Chromosome:
19
Start:
16,067,021 bp from pter
End:
16,103,005 bp from pter
Size:
35,985 bases
Orientation:
Plus strand

Genomic View for TPM4 Gene

Genes around TPM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPM4 Gene

Proteins for TPM4 Gene

  • Protein details for TPM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P67936-TPM4_HUMAN
    Recommended name:
    Tropomyosin alpha-4 chain
    Protein Accession:
    P67936
    Secondary Accessions:
    • P07226
    • Q15659
    • Q5U0D9
    • Q9BU85
    • Q9H8Q3
    • Q9UCS1
    • Q9UCS2
    • Q9UCS3
    • Q9UCS4

    Protein attributes for TPM4 Gene

    Size:
    248 amino acids
    Molecular mass:
    28522 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta chain.

    Alternative splice isoforms for TPM4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPM4 Gene

Proteomics data for TPM4 Gene at MOPED

Post-translational modifications for TPM4 Gene

  • Ubiquitination at Lys 13, Lys 190, and Lys 228
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TPM4 Gene

Domains & Families for TPM4 Gene

Gene Families for TPM4 Gene

Protein Domains for TPM4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TPM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P67936

UniProtKB/Swiss-Prot:

TPM4_HUMAN :
  • The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
  • Belongs to the tropomyosin family.
Domain:
  • The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
Family:
  • Belongs to the tropomyosin family.
genes like me logo Genes that share domains with TPM4: view

Function for TPM4 Gene

Molecular function for TPM4 Gene

GENATLAS Biochemistry:
tropomyosin 4,alpha,skeletal muscle and non muscle isoforms,dimerizing to form a helical coiled coil binding to actin in the troponin complex (thin filamant) that regulates calcium-dependent binding of actin and myosin and muscle contraction
UniProtKB/Swiss-Prot Function:
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.
genes like me logo Genes that share phenotypes with TPM4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TPM4

miRNA for TPM4 Gene

miRTarBase miRNAs that target TPM4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPM4 Gene

Localization for TPM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPM4 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPM4 Gene COMPARTMENTS Subcellular localization image for TPM4 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5

Gene Ontology (GO) - Cellular Components for TPM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 16236705
GO:0005856 cytoskeleton TAS 16130169
GO:0016020 membrane IDA 16210410
genes like me logo Genes that share ontologies with TPM4: view

Pathways & Interactions for TPM4 Gene

genes like me logo Genes that share pathways with TPM4: view

Gene Ontology (GO) - Biological Process for TPM4 Gene

None

No data available for SIGNOR curated interactions for TPM4 Gene

Drugs & Compounds for TPM4 Gene

(1) Drugs for TPM4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with TPM4: view

Transcripts for TPM4 Gene

Unigene Clusters for TPM4 Gene

Tropomyosin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPM4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - - - -
SP2: - - - -
SP3: -
SP4: -
SP5: - - -
SP6: - - - -
SP7: -

Relevant External Links for TPM4 Gene

GeneLoc Exon Structure for
TPM4
ECgene alternative splicing isoforms for
TPM4

Expression for TPM4 Gene

mRNA expression in normal human tissues for TPM4 Gene

Protein differential expression in normal tissues from HIPED for TPM4 Gene

This gene is overexpressed in Platelet (9.0) and Bone marrow stromal cell (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPM4 Gene



SOURCE GeneReport for Unigene cluster for TPM4 Gene Hs.631618

mRNA Expression by UniProt/SwissProt for TPM4 Gene

P67936-TPM4_HUMAN
Tissue specificity: Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level).
genes like me logo Genes that share expression patterns with TPM4: view

Protein tissue co-expression partners for TPM4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TPM4 Gene

Orthologs for TPM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPM4 36
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TPM4 35
  • 93.78 (n)
  • 98.59 (a)
TPM4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPM4 36
  • 99 (a)
OneToOne
TPM4 35
  • 92.72 (n)
  • 98.94 (a)
mouse
(Mus musculus)
Mammalia Tpm4 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TPM4 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TPM4 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves TPM4 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TPM4 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.568 35
zebrafish
(Danio rerio)
Actinopterygii tpm4b 36
  • 78 (a)
ManyToMany
tpm4a 35
  • 76.64 (n)
  • 84.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tm1 36
  • 21 (a)
ManyToMany
Tm2 36
  • 46 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lev-11 36
  • 56 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10371 36
  • 63 (a)
ManyToMany
CSA.11015 36
  • 69 (a)
ManyToMany
Species with no ortholog for TPM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPM4 Gene

ENSEMBL:
Gene Tree for TPM4 (if available)
TreeFam:
Gene Tree for TPM4 (if available)

Paralogs for TPM4 Gene

Paralogs for TPM4 Gene

genes like me logo Genes that share paralogs with TPM4: view

Variants for TPM4 Gene

Sequence variations from dbSNP and Humsavar for TPM4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_036535 A breast cancer sample
rs1143209 -- 16,102,082(+) gcgtt(G/T)gcttt utr-variant-3-prime
rs1862601 -- 16,075,695(-) GAGTT(A/C)AGCAA intron-variant, upstream-variant-2KB
rs1862602 -- 16,075,255(-) GATTA(C/G)AAACC intron-variant, upstream-variant-2KB
rs3786574 -- 16,082,807(-) accac(A/G)ttgcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPM4 Gene

Variant ID Type Subtype PubMed ID
nsv911157 CNV Loss 21882294
nsv137994 CNV Loss 16902084
esv2718258 CNV Deletion 23290073

Variation tolerance for TPM4 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPM4 Gene

HapMap Linkage Disequilibrium report
TPM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPM4 Gene

Disorders for TPM4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TPM4 Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
inflammatory myofibroblastic tumor
  • inflammatory fibrosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search TPM4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TPM4

Genetic Association Database (GAD)
TPM4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPM4
genes like me logo Genes that share disorders with TPM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPM4 Gene

Publications for TPM4 Gene

  1. A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans. (PMID: 22423221) Qayyum R. … Reiner A.P. (PLoS Genet. 2012) 3 48 67
  2. Assignment of the human alpha-tropomyosin gene TPM4 to band 19p13.1 by fluorescence in situ hybridization. (PMID: 8641132) Wilton S.D. … Laing N.G. (Cytogenet. Cell Genet. 1996) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for TPM4 Gene

Sources for TPM4 Gene

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