Aliases for TPH2 Gene
External Ids for TPH2 Gene
Previous GeneCards Identifiers for TPH2 Gene
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016]
GeneCards Summary for TPH2 Gene
TPH2 (Tryptophan Hydroxylase 2) is a Protein Coding gene. Diseases associated with TPH2 include Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment and Tryptophan Hydroxylase Deficiency. Among its related pathways are Circadian entrainment and serotonin and melatonin biosynthesis. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen. An important paralog of this gene is TPH1.
Hydroxylases are enzymes that catalyze the addition of hydroxyl groups to substrates during oxidation reactions. This diverse group of enzymes includes tryptophan hydroxylase (E.C. 18.104.22.168), steroid 11-beta hydroxylase (E.C. 22.214.171.124), and LTB4 omega-hydroxylase (E.C. 126.96.36.199).