Aliases for TPH1 Gene
External Ids for TPH1 Gene
Previous HGNC Symbols for TPH1 Gene
Previous GeneCards Identifiers for TPH1 Gene
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009]
GeneCards Summary for TPH1 Gene
TPH1 (Tryptophan Hydroxylase 1) is a Protein Coding gene. Diseases associated with TPH1 include perry syndrome and early myoclonic encephalopathy. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include iron ion binding and tryptophan 5-monooxygenase activity. An important paralog of this gene is TH.
Hydroxylases are enzymes that catalyze the addition of -OH (hydroxyl) groups to their substrate during oxidation reactions. This diverse group of enzymes includes tryptophan hydroxylase (E.C. 126.96.36.199), which is involved in serotonin synthesis; steroid 11-beta hydroxylase (also known as CYP11B1) (E.C. 188.8.131.52), which is involved in glucocorticoid synthesis; and LTB4 omega-hydroxylase (also known as CYP4F3) (E.C. 184.108.40.206), which is involved in arachidonic acid metabolism.