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Aliases for TPGS2 Gene

Aliases for TPGS2 Gene

  • Tubulin Polyglutamylase Complex Subunit 2 2 3 5
  • C18orf10 3 4
  • PGS2 3 4
  • Chromosome 18 Open Reading Frame 10 2
  • HMFN0601 3
  • L17 3

External Ids for TPGS2 Gene

Previous HGNC Symbols for TPGS2 Gene

  • C18orf10

Previous GeneCards Identifiers for TPGS2 Gene

  • GC18M034377
  • GC18M034359

Summaries for TPGS2 Gene

Entrez Gene Summary for TPGS2 Gene

  • This gene encodes a protein that is a component of the neuronal polyglutamylase complex, which plays a role in post-translational addition of glutamate residues to C-terminal tubulin tails. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for TPGS2 Gene

TPGS2 (Tubulin Polyglutamylase Complex Subunit 2) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPGS2 Gene

Genomics for TPGS2 Gene

Regulatory Elements for TPGS2 Gene

Enhancers for TPGS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F036691 0.9 Ensembl ENCODE 19.1 +136.1 136111 3.3 TFAP4 FOXA3 BHLHE40 RAD21 ZNF7 TEAD3 JUND CEBPA GLIS1 TPGS2 LOC105372071 KIAA1328
GH18F036827 1.1 ENCODE 14.2 +0.4 446 3.3 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 ZNF263 ENSG00000267707 TPGS2 KIAA1328 LOC105372071
GH18F036711 0.8 Ensembl ENCODE 19.1 +117.5 117508 0.9 JUND MAZ GLIS1 ZFP37 KLF17 FOS NFE2L2 TPGS2 LOC105372071 KIAA1328
GH18F036671 0.9 Ensembl ENCODE 13.3 +156.5 156474 1.9 PKNOX1 MAFG CEBPB FEZF1 CEBPG EP300 STAT3 NFE2 IRF1 SPI1 TPGS2 LOC105372071 KIAA1328
GH18F036814 0.7 ENCODE 8.9 +14.1 14135 0.7 RFX1 TAL1 ZBTB8A FEZF1 ZIC2 ARID1B OSR2 NCOR1 IKZF1 GLIS1 TPGS2 KIAA1328 LOC105372071
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TPGS2 on UCSC Golden Path with GeneCards custom track

Promoters for TPGS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000277228 592 2800 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 ZNF263

Genomic Location for TPGS2 Gene

36,777,647 bp from pter
36,829,393 bp from pter
51,747 bases
Minus strand

Genomic View for TPGS2 Gene

Genes around TPGS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPGS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPGS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPGS2 Gene

Proteins for TPGS2 Gene

  • Protein details for TPGS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tubulin polyglutamylase complex subunit 2
    Protein Accession:
    Secondary Accessions:
    • B4DIX2
    • K7EIJ9
    • Q4KN59
    • Q8WTU3
    • Q96BT9
    • Q9Y435

    Protein attributes for TPGS2 Gene

    300 amino acids
    Molecular mass:
    33318 Da
    Quaternary structure:
    • Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.
    • Sequence=AAH22199.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB43322.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TPGS2 Gene


neXtProt entry for TPGS2 Gene

Post-translational modifications for TPGS2 Gene

  • Ubiquitination at Lys 14
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TPGS2 Gene

Domains & Families for TPGS2 Gene

Protein Domains for TPGS2 Gene


Suggested Antigen Peptide Sequences for TPGS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TPGS2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TPGS2 Gene

Function for TPGS2 Gene

Phenotypes for TPGS2 Gene

genes like me logo Genes that share phenotypes with TPGS2: view

Animal Models for TPGS2 Gene

MGI Knock Outs for TPGS2:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TPGS2 Gene

Localization for TPGS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPGS2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPGS2 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TPGS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TPGS2: view

Pathways & Interactions for TPGS2 Gene

SuperPathways for TPGS2 Gene

No Data Available

Interacting Proteins for TPGS2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000335144 Q68CL5-TPGS2_HUMAN for TPGS2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TPGS2 Gene


No data available for Pathways by source and SIGNOR curated interactions for TPGS2 Gene

Transcripts for TPGS2 Gene

Unigene Clusters for TPGS2 Gene

Tubulin polyglutamylase complex subunit 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPGS2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i · 1j ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a ·
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - -
SP9: - - -
SP10: - - - - -
SP11: - - - - - - -
SP12: - - - -
SP13: - -

ExUns: 10b · 10c ^ 11
SP1: - -
SP3: - -

Relevant External Links for TPGS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPGS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TPGS2 Gene

Protein differential expression in normal tissues from HIPED for TPGS2 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TPGS2 Gene

Protein tissue co-expression partners for TPGS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TPGS2 Gene:


SOURCE GeneReport for Unigene cluster for TPGS2 Gene:

genes like me logo Genes that share expression patterns with TPGS2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TPGS2 Gene

Orthologs for TPGS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPGS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TPGS2 34 35
  • 100 (n)
(Bos Taurus)
Mammalia TPGS2 34
  • 91.97 (n)
C24H18ORF10 35
  • 91 (a)
(Canis familiaris)
Mammalia TPGS2 34 35
  • 90.3 (n)
(Rattus norvegicus)
Mammalia Tpgs2 34
  • 88.81 (n)
(Mus musculus)
Mammalia Tpgs2 34 16 35
  • 88.44 (n)
(Ornithorhynchus anatinus)
Mammalia TPGS2 35
  • 77 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 73 (a)
-- 35
  • 65 (a)
(Gallus gallus)
Aves C18ORF10 34
  • 73.01 (n)
TPGS2 35
  • 71 (a)
(Anolis carolinensis)
Reptilia TPGS2 35
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tpgs2 34
  • 68.91 (n)
(Danio rerio)
Actinopterygii tpgs2 34 35
  • 61.52 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010475 34
  • 46.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6931 34 35
  • 46.53 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
Species where no ortholog for TPGS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TPGS2 Gene

Gene Tree for TPGS2 (if available)
Gene Tree for TPGS2 (if available)

Paralogs for TPGS2 Gene

No data available for Paralogs for TPGS2 Gene

Variants for TPGS2 Gene

Sequence variations from dbSNP and Humsavar for TPGS2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs10048257 -- 36,826,633(+) gcagg(A/C)ccgag intron-variant
rs10163581 -- 36,813,403(+) ATCCA(A/C)GAATG intron-variant
rs1045781 -- 36,818,951(-) ACTGA(A/G)GTGAC nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime
rs1057509 -- 36,788,885(-) CGTCC(A/T)CCTAG intron-variant
rs111417116 -- 36,791,562(+) GGTAA(C/T)ATAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPGS2 Gene

Variant ID Type Subtype PubMed ID
nsv817789 CNV gain 17921354
nsv576651 CNV loss 21841781
nsv438283 CNV loss 16468122
esv3642237 CNV gain 21293372
esv3642236 CNV loss 21293372
esv3583016 CNV loss 25503493
esv34228 CNV gain 17911159
esv2758722 CNV gain 17122850

Variation tolerance for TPGS2 Gene

Residual Variation Intolerance Score: 24.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.44; 64.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPGS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPGS2 Gene

Disorders for TPGS2 Gene

Relevant External Links for TPGS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TPGS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPGS2 Gene

Publications for TPGS2 Gene

  1. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S. … Nakagawara A. (Oncogene 2004) 3 4 64
  2. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J. … Carter P. (Oncogene 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for TPGS2 Gene

Sources for TPGS2 Gene

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