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Aliases for TPGS2 Gene

Aliases for TPGS2 Gene

  • Tubulin Polyglutamylase Complex Subunit 2 2 3 5
  • C18orf10 3 4
  • PGS2 3 4
  • Chromosome 18 Open Reading Frame 10 2
  • HMFN0601 3
  • L17 3

External Ids for TPGS2 Gene

Previous HGNC Symbols for TPGS2 Gene

  • C18orf10

Previous GeneCards Identifiers for TPGS2 Gene

  • GC18M034377
  • GC18M034359

Summaries for TPGS2 Gene

Entrez Gene Summary for TPGS2 Gene

  • This gene encodes a protein that is a component of the neuronal polyglutamylase complex, which plays a role in post-translational addition of glutamate residues to C-terminal tubulin tails. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for TPGS2 Gene

TPGS2 (Tubulin Polyglutamylase Complex Subunit 2) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPGS2 Gene

Genomics for TPGS2 Gene

Regulatory Elements for TPGS2 Gene

Promoters for TPGS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TPGS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TPGS2 Gene

Chromosome:
18
Start:
36,777,647 bp from pter
End:
36,829,393 bp from pter
Size:
51,747 bases
Orientation:
Minus strand

Genomic View for TPGS2 Gene

Genes around TPGS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPGS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPGS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPGS2 Gene

Proteins for TPGS2 Gene

  • Protein details for TPGS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CL5-TPGS2_HUMAN
    Recommended name:
    Tubulin polyglutamylase complex subunit 2
    Protein Accession:
    Q68CL5
    Secondary Accessions:
    • B4DIX2
    • K7EIJ9
    • Q4KN59
    • Q8WTU3
    • Q96BT9
    • Q9Y435

    Protein attributes for TPGS2 Gene

    Size:
    300 amino acids
    Molecular mass:
    33318 Da
    Quaternary structure:
    • Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.
    SequenceCaution:
    • Sequence=AAH22199.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB43322.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TPGS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPGS2 Gene

Proteomics data for TPGS2 Gene at MOPED

Post-translational modifications for TPGS2 Gene

  • Ubiquitination at Lys 14
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TPGS2 Gene

Domains & Families for TPGS2 Gene

Protein Domains for TPGS2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TPGS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TPGS2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TPGS2 Gene

Function for TPGS2 Gene

Phenotypes for TPGS2 Gene

genes like me logo Genes that share phenotypes with TPGS2: view

Animal Models for TPGS2 Gene

MGI Knock Outs for TPGS2:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TPGS2 Gene

Localization for TPGS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPGS2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPGS2 Gene COMPARTMENTS Subcellular localization image for TPGS2 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TPGS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TPGS2: view

Pathways & Interactions for TPGS2 Gene

SuperPathways for TPGS2 Gene

No Data Available

Interacting Proteins for TPGS2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000335144%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000403397%0d%0a
Selected Interacting proteins: Q68CL5-TPGS2_HUMAN ENSP00000335144 for TPGS2 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for TPGS2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TPGS2 Gene

Drugs & Compounds for TPGS2 Gene

No Compound Related Data Available

Transcripts for TPGS2 Gene

Unigene Clusters for TPGS2 Gene

Tubulin polyglutamylase complex subunit 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPGS2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i · 1j ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a ·
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - -
SP9: - - -
SP10: - - - - -
SP11: - - - - - - -
SP12: - - - -
SP13: - -

ExUns: 10b · 10c ^ 11
SP1: - -
SP2:
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for TPGS2 Gene

GeneLoc Exon Structure for
TPGS2
ECgene alternative splicing isoforms for
TPGS2

Expression for TPGS2 Gene

mRNA expression in normal human tissues for TPGS2 Gene

Protein differential expression in normal tissues from HIPED for TPGS2 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TPGS2 Gene



SOURCE GeneReport for Unigene cluster for TPGS2 Gene Hs.436636

genes like me logo Genes that share expression patterns with TPGS2: view

Protein tissue co-expression partners for TPGS2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TPGS2 Gene

Orthologs for TPGS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPGS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPGS2 36
  • 100 (a)
OneToOne
TPGS2 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia TPGS2 35
  • 91.97 (n)
  • 91.61 (a)
C24H18ORF10 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPGS2 36
  • 91 (a)
OneToOne
TPGS2 35
  • 90.3 (n)
  • 90.75 (a)
mouse
(Mus musculus)
Mammalia Tpgs2 16
Tpgs2 36
  • 86 (a)
OneToOne
Tpgs2 35
  • 88.44 (n)
  • 88.19 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 65 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TPGS2 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tpgs2 35
  • 88.81 (n)
  • 87.08 (a)
chicken
(Gallus gallus)
Aves C18ORF10 35
  • 73.01 (n)
  • 75.75 (a)
TPGS2 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TPGS2 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tpgs2 35
  • 68.91 (n)
  • 66.8 (a)
zebrafish
(Danio rerio)
Actinopterygii tpgs2 35
  • 61.52 (n)
  • 58.69 (a)
tpgs2 36
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010475 35
  • 46.72 (n)
  • 32.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6931 35
  • 46.53 (n)
  • 34.16 (a)
CG6931 36
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for TPGS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TPGS2 Gene

ENSEMBL:
Gene Tree for TPGS2 (if available)
TreeFam:
Gene Tree for TPGS2 (if available)

Paralogs for TPGS2 Gene

No data available for Paralogs for TPGS2 Gene

Variants for TPGS2 Gene

Sequence variations from dbSNP and Humsavar for TPGS2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs2303507 - 36,818,920(-) CTGAA(C/T)GTCAT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs11570 -- 36,798,547(-) TCACA(G/T)ACACC intron-variant, nc-transcript-variant, reference, missense
rs576783 -- 36,784,061(+) aatag(C/G)tgctg intron-variant
rs674549 -- 36,784,113(+) atttt(A/G)gctca intron-variant
rs519309 -- 36,804,871(-) GTAAA(C/T)GGCAA intron-variant

Variation tolerance for TPGS2 Gene

Residual Variation Intolerance Score: 24.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.44; 64.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPGS2 Gene

HapMap Linkage Disequilibrium report
TPGS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TPGS2 Gene

Disorders for TPGS2 Gene

Relevant External Links for TPGS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPGS2

No disorders were found for TPGS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPGS2 Gene

Publications for TPGS2 Gene

  1. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S. … Nakagawara A. (Oncogene 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  5. Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years. (PMID: 24347629) Shaffer J.R. … Marazita M.L. (G3 (Bethesda) 2014) 3

Products for TPGS2 Gene

Sources for TPGS2 Gene

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