TPGS1 Gene
protein-coding GIFtS: 37
GCID: GC19P000509
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tubulin polyglutamylase complex subunit 1(Previous name: chromosome 19 open reading frame 20 )
(Previous symbol: C19orf20)
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Aliases
for TPGS1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tubulin Polyglutamylase Complex Subunit 11 2 | | C19orf201 2 3 | | PGs11 2 3 | | GTRGEO221 2 | | Chromosome 19 Open Reading Frame 201 | | Gene Trap ROSA B-Geo 222 |
Export aliases for TPGS1 gene to outside databases |
Summaries
for TPGS1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TPGS1_HUMAN, Q6ZTW0Function: May act in the targeting of the tubulin polyglutamylase complex. Required for the development of thespermatid flagellum (By similarity)
|
Genomic Views
for TPGS1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TPGS1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TPGS1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPGS1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3TPGS1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P000509: view genomic region
(about GC identifiers)
Start:
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507,299 bp from pter |
End:
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519,654 bp from pter |
Size:
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12,356 bases |
Orientation:
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plus strand |
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Proteins
for TPGS1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TPGS1_HUMAN, Q6ZTW0 (See
protein sequence)Recommended Name: Tubulin polyglutamylase complex subunit 1 Size: 290 amino acids; 31275 Da
Subunit: Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1 (Bysimilarity)
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm,cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, flagellum basal body. Cell projection, axon. Cellprojection, dendrite. Cytoplasm, cytoskeleton, centrosome. Note=Associated with microtubules from neurites,centrosomes, basal bodies and axonemes (By similarity)
Secondary accessions: Q96GE2Alternative splicing: 2 isoforms: Q6ZTW0-1 Q6ZTW0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TPGS1: NX_Q6ZTW0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZTW0
TPGS1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_277048.2
ENSEMBL proteins: ENSP00000352265
Human Recombinant Protein Products for TPGS1:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
TPGS1 for ontologies About GeneDecksing
TPGS1 Antibody Products:
Assay Products for TPGS1: |
Protein
Domains /
Families
for TPGS1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6ZTW0 |
Function
for TPGS1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TPGS1_HUMAN, Q6ZTW0Function: May act in the targeting of the tubulin polyglutamylase complex. Required for the development of thespermatid flagellum (By similarity)Phenotypes:
1 GenomeRNAi human phenotype for TPGS1:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tpgs1):
TPGS1 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPGS1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPGS1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for TPGS1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TPGS1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPGS1 |
|
Pathways & Interactions
for TPGS1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TPGS1
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for TPGS1 (ENSP000003522654) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0007288 | sperm axoneme assembly |
IEA | -- | | GO:0030534 | adult behavior |
IEA | -- |
TPGS1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TPGS1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TPGS1
Search CenterWatch for drugs/clinical trials and news about TPGS1
|
Transcripts
for TPGS1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TPGS1 gene: NM_033513.2 Unigene Cluster for TPGS1: Tubulin polyglutamylase complex subunit 1 Hs.369613 [show with all ESTs]Unigene Representative Sequence: BM9134262 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000359315(uc002lou.3) ENST00000588278
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPGS1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPGS1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for TPGS1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TPGS1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPGS1 |
Additional cDNA sequence: BC009520.1 4 DOTS entries: DT.75101461 DT.70104698 DT.101972195 DT.91923361 24/35 AceView cDNA sequences (see all 35): AI478144 BF311688 AW196412 AW050879 BC009520 AW183808 AI990682 BM846833 AI972304 CF128273 AK125401 BG337757 BF108774 AW772085 AI738612 AK126170 AI598187 AI673255 AI800587 BM846349 BF476504 BU951639 AI392869 NM_033513
GeneLoc Exon Structure
|
Expression
for TPGS1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TPGS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCCGCGAGG
About this image
See TPGS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TPGS1
SOURCE GeneReport for Unigene cluster: Hs.369613
SABiosciences Custom PCR Arrays for TPGS1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TPGS1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TPGS1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPGS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPGS1 |
Orthologs
for TPGS1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TPGS1 gene from 4/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tpgs11 , 5 |
predicted gene, Gm165175
tubulin polyglutamylase complex subunit 11 |
83.79(n)1
86.21(a)1 |
|
10 (39.72 cM)5
1100121 NM_148934.21 NP_683736.11
796694105 |
chicken
(Gallus gallus) |
Aves |
LOC1008575351 |
tubulin polyglutamylase complex subunit 1-like |
68.86(n)
66.06(a) |
|
100857535 XM_003642859.1 XP_003642907.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.31432 |
Xenopus laevis transcribed sequences |
72.66(n) |
|
48054648 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1001483091 |
tubulin polyglutamylase complex subunit 1-like |
55.43(n)
40.91(a) |
|
100148309 XM_003197973.1 XP_003198021.1 |
ENSEMBL Gene Tree for TPGS1 (if available)
TreeFam Gene Tree for TPGS1 (if available) |
Paralogs
for TPGS1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TPGS1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TPGS1 (507299 - 519654 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TPGS1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPGS1 |
|
Disorders
/ Diseases
for TPGS1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TPGS1 for disorders About GeneDecksing
1  disease for TPGS1: About MalaCardsneuronitis
Export disorders for TPGS1 gene to outside databases
|
Publications
for TPGS1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TPGS1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TPGS1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Characterisation of PGs1, a subunit of a protein complex co-purifying with tubulin polyglutamylase. (PubMed id 12972506)1, 3 Regnard C....Edde B. (2003)
- Human chromosome 19 and related regions in mouse: con servative and lineage-specific evolution. (PubMed id 11441184)1, 3 Dehal P....Stubbs L. (2001)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TPGS1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TPGS1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TPGS1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TPGS1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TPGS1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TPGS1 gene:
Search GeneIP for patents involving TPGS1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TPGS1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TPGS1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TPGS1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TPGS1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TPGS1 | | OriGene 3'-UTR Clone for TPGS1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPGS1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPGS1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TPGS1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPGS1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPGS1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TPGS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPGS1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPGS1 |
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| | | | Search Tocris compounds for TPGS1 |
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 | | | TPGS1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | ThermoFisher Antibodies for TPGS1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPGS1 |
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