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Aliases for TPGS1 Gene

Aliases for TPGS1 Gene

  • Tubulin Polyglutamylase Complex Subunit 1 2 3 5
  • C19orf20 3 4
  • PGs1 3 4
  • Chromosome 19 Open Reading Frame 20 2
  • Gene Trap ROSA B-Geo 22 3
  • GTRGEO22 3

External Ids for TPGS1 Gene

Previous HGNC Symbols for TPGS1 Gene

  • C19orf20

Summaries for TPGS1 Gene

GeneCards Summary for TPGS1 Gene

TPGS1 (Tubulin Polyglutamylase Complex Subunit 1) is a Protein Coding gene. GO annotations related to this gene include microtubule binding and tubulin-glutamic acid ligase activity.

UniProtKB/Swiss-Prot for TPGS1 Gene

  • May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPGS1 Gene

Genomics for TPGS1 Gene

Regulatory Elements for TPGS1 Gene

Enhancers for TPGS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G000510 2 FANTOM5 Ensembl ENCODE dbSUPER 6.4 +4.3 4315 3.1 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 FEZF1 GZMM TPGS1 MADCAM1 RNF126 LOC105372232 CDC34
GH19G000516 1.5 Ensembl ENCODE dbSUPER 6.5 +10.7 10694 3.3 HDGF ATF1 ARNT AGO1 TCF12 GATA2 KLF13 ZNF263 NCOA1 ZNF592 CFD BSG MIDN TPGS1 LOC105372232 CDC34
GH19G000867 0.8 FANTOM5 3.7 +359.7 359706 0.4 KLF1 PTBP1 AGO1 ZIC2 ZNF48 CCNT2 FOXM1 HIC1 ZFHX2 POLR2A CFD MED16 ODF3L2 ATP5D GPX4 TPGS1 CNN2 POLRMT BSG C19orf24
GH19G000747 1.9 FANTOM5 Ensembl ENCODE dbSUPER 1.4 +244.4 244419 9.4 ATF1 FOXA2 PKNOX1 ARID4B SIN3A BRCA1 ZBTB7B ZNF143 FOS SP5 MISP PRTN3 ELANE CFD CIRBP ENSG00000268798 FSTL3 PLPP2 TPGS1 GC19P000749
GH19G000506 1.4 ENCODE dbSUPER 0.7 +0.1 99 2.7 FOXA2 PKNOX1 CREB3L1 MLX ARNT AGO1 ARID4B SIN3A DMAP1 FEZF1 CIRBP ENSG00000268798 MADCAM1 C2CD4C LOC105372232 TPGS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TPGS1 on UCSC Golden Path with GeneCards custom track

Promoters for TPGS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000105476 -97 1601 FOXA2 PKNOX1 CREB3L1 MLX ARNT AGO1 ARID4B SIN3A DMAP1 FEZF1

Genomic Location for TPGS1 Gene

Chromosome:
19
Start:
507,497 bp from pter
End:
519,654 bp from pter
Size:
12,158 bases
Orientation:
Plus strand

Genomic View for TPGS1 Gene

Genes around TPGS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPGS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPGS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPGS1 Gene

Proteins for TPGS1 Gene

  • Protein details for TPGS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZTW0-TPGS1_HUMAN
    Recommended name:
    Tubulin polyglutamylase complex subunit 1
    Protein Accession:
    Q6ZTW0
    Secondary Accessions:
    • Q96GE2

    Protein attributes for TPGS1 Gene

    Size:
    290 amino acids
    Molecular mass:
    31275 Da
    Quaternary structure:
    • Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.

    Alternative splice isoforms for TPGS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPGS1 Gene

Post-translational modifications for TPGS1 Gene

  • Ubiquitination at Lys54
  • Modification sites at PhosphoSitePlus

Other Protein References for TPGS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TPGS1 Gene

Domains & Families for TPGS1 Gene

Protein Domains for TPGS1 Gene

Suggested Antigen Peptide Sequences for TPGS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TPGS1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TPGS1 Gene

Function for TPGS1 Gene

Molecular function for TPGS1 Gene

UniProtKB/Swiss-Prot Function:
May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity).

Gene Ontology (GO) - Molecular Function for TPGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding IEA --
GO:0015631 tubulin binding IEA --
GO:0070740 tubulin-glutamic acid ligase activity IEA --
genes like me logo Genes that share ontologies with TPGS1: view
genes like me logo Genes that share phenotypes with TPGS1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPGS1 Gene

Localization for TPGS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPGS1 Gene

Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, flagellum basal body. Cell projection, axon. Cell projection, dendrite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with microtubules from neurites, centrosomes, basal bodies and axonemes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPGS1 gene
Compartment Confidence
cytoskeleton 5
nucleus 2
plasma membrane 1
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TPGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TPGS1: view

Pathways & Interactions for TPGS1 Gene

SuperPathways for TPGS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TPGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 chemical synaptic transmission IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0007288 sperm axoneme assembly IEA --
GO:0018095 protein polyglutamylation IEA --
genes like me logo Genes that share ontologies with TPGS1: view

No data available for Pathways by source and SIGNOR curated interactions for TPGS1 Gene

Transcripts for TPGS1 Gene

mRNA/cDNA for TPGS1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(35) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TPGS1 Gene

Tubulin polyglutamylase complex subunit 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPGS1 Gene

No ASD Table

Relevant External Links for TPGS1 Gene

GeneLoc Exon Structure for
TPGS1
ECgene alternative splicing isoforms for
TPGS1

Expression for TPGS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPGS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TPGS1 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TPGS1 Gene



Protein tissue co-expression partners for TPGS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TPGS1 Gene:

TPGS1

SOURCE GeneReport for Unigene cluster for TPGS1 Gene:

Hs.369613
genes like me logo Genes that share expression patterns with TPGS1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPGS1 Gene

Orthologs for TPGS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TPGS1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TPGS1 34 35
  • 88.74 (n)
cow
(Bos Taurus)
Mammalia TPGS1 34 35
  • 87.82 (n)
mouse
(Mus musculus)
Mammalia Tpgs1 34 16 35
  • 83.79 (n)
rat
(Rattus norvegicus)
Mammalia Tpgs1 34
  • 82.53 (n)
oppossum
(Monodelphis domestica)
Mammalia TPGS1 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves TPGS1 34 35
  • 68.86 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tpgs1 34
  • 57.33 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3143 34
zebrafish
(Danio rerio)
Actinopterygii TPGS1 (1 of 2) 35
  • 39 (a)
OneToMany
CR774186.2 35
  • 37 (a)
OneToMany
Species where no ortholog for TPGS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TPGS1 Gene

ENSEMBL:
Gene Tree for TPGS1 (if available)
TreeFam:
Gene Tree for TPGS1 (if available)

Paralogs for TPGS1 Gene

No data available for Paralogs for TPGS1 Gene

Variants for TPGS1 Gene

Sequence variations from dbSNP and Humsavar for TPGS1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000152843 -- 514,582(+) ACCAC(A/C)GGTGG intron-variant
rs1000265907 -- 509,353(+) CTGCA(A/C)AAGCC intron-variant, upstream-variant-2KB
rs1000573842 -- 506,260(+) TCCTG(A/C)CCTCG intron-variant, upstream-variant-2KB
rs1000762902 -- 509,165(+) GAAGA(A/G)CTCAG intron-variant, upstream-variant-2KB
rs1000809319 -- 511,682(+) AGCTG(A/G)ACCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPGS1 Gene

Variant ID Type Subtype PubMed ID
dgv1013e212 CNV gain 25503493
dgv1674n106 CNV deletion 24896259
dgv6155n54 CNV loss 21841781
dgv6166n54 CNV gain 21841781
dgv6167n54 CNV gain 21841781
esv2717714 CNV deletion 23290073
esv28250 CNV gain+loss 19812545
esv33417 CNV gain+loss 17666407
esv3574264 CNV gain 25503493
nsv428360 CNV gain 18775914
nsv470101 CNV loss 18288195
nsv509712 CNV insertion 20534489
nsv516566 CNV gain 19592680
nsv577978 CNV gain 21841781
nsv578123 CNV gain 21841781
nsv578125 CNV loss 21841781
nsv578127 CNV gain 21841781
nsv953938 CNV deletion 24416366

Variation tolerance for TPGS1 Gene

Gene Damage Index Score: 4.01; 60.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPGS1 Gene

Human Gene Mutation Database (HGMD)
TPGS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TPGS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPGS1 Gene

Disorders for TPGS1 Gene

Relevant External Links for TPGS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPGS1

No disorders were found for TPGS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPGS1 Gene

Publications for TPGS1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Characterisation of PGs1, a subunit of a protein complex co-purifying with tubulin polyglutamylase. (PMID: 12972506) Regnard C. … EddAc B. (J. Cell. Sci. 2003) 2 3 64
  4. Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. (PMID: 11441184) Dehal P. … Stubbs L. (Science 2001) 2 3 64
  5. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3 64

Products for TPGS1 Gene

Sources for TPGS1 Gene

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