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Aliases for TPGS1 Gene

Aliases for TPGS1 Gene

  • Tubulin Polyglutamylase Complex Subunit 1 2 3
  • C19orf20 3 4
  • PGs1 3 4
  • Chromosome 19 Open Reading Frame 20 2
  • Gene Trap ROSA B-Geo 22 3
  • GTRGEO22 3

External Ids for TPGS1 Gene

Previous HGNC Symbols for TPGS1 Gene

  • C19orf20

Summaries for TPGS1 Gene

GeneCards Summary for TPGS1 Gene

TPGS1 (Tubulin Polyglutamylase Complex Subunit 1) is a Protein Coding gene. GO annotations related to this gene include microtubule binding and tubulin-glutamic acid ligase activity.

UniProtKB/Swiss-Prot for TPGS1 Gene

  • May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPGS1 Gene

Genomics for TPGS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TPGS1 Gene

Chromosome:
19
Start:
507,497 bp from pter
End:
519,654 bp from pter
Size:
12,158 bases
Orientation:
Plus strand

Genomic View for TPGS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPGS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPGS1 Gene

No data available for Regulatory Elements for TPGS1 Gene

Proteins for TPGS1 Gene

  • Protein details for TPGS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZTW0-TPGS1_HUMAN
    Recommended name:
    Tubulin polyglutamylase complex subunit 1
    Protein Accession:
    Q6ZTW0
    Secondary Accessions:
    • Q96GE2

    Protein attributes for TPGS1 Gene

    Size:
    290 amino acids
    Molecular mass:
    31275 Da
    Quaternary structure:
    • Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.

    Alternative splice isoforms for TPGS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPGS1 Gene

Proteomics data for TPGS1 Gene at MOPED

Post-translational modifications for TPGS1 Gene

  • Ubiquitination at Lys 54
  • Modification sites at PhosphoSitePlus

Other Protein References for TPGS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TPGS1 Gene

Domains & Families for TPGS1 Gene

Protein Domains for TPGS1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TPGS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TPGS1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TPGS1 Gene

Function for TPGS1 Gene

Molecular function for TPGS1 Gene

UniProtKB/Swiss-Prot Function:
May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity).

Gene Ontology (GO) - Molecular Function for TPGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008017 microtubule binding IEA --
GO:0015631 tubulin binding --
GO:0070740 tubulin-glutamic acid ligase activity IEA --
genes like me logo Genes that share ontologies with TPGS1: view
genes like me logo Genes that share phenotypes with TPGS1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPGS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TPGS1 Gene

Localization for TPGS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPGS1 Gene

Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, flagellum basal body. Cell projection, axon. Cell projection, dendrite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with microtubules from neurites, centrosomes, basal bodies and axonemes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPGS1 Gene COMPARTMENTS Subcellular localization image for TPGS1 gene
Compartment Confidence
cytoskeleton 5

Gene Ontology (GO) - Cellular Components for TPGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005874 microtubule IEA --
GO:0030424 axon IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with TPGS1: view

Pathways & Interactions for TPGS1 Gene

SuperPathways for TPGS1 Gene

No Data Available

Interacting Proteins for TPGS1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000352265%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000218439%0d%0a
Selected Interacting proteins: ENSP00000352265 for TPGS1 Gene via STRING

Gene Ontology (GO) - Biological Process for TPGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 synaptic transmission IEA --
GO:0007275 multicellular organismal development IEA --
GO:0007288 sperm axoneme assembly IEA --
GO:0018095 protein polyglutamylation IEA --
GO:0030534 adult behavior IEA --
genes like me logo Genes that share ontologies with TPGS1: view

No data available for Pathways by source and SIGNOR curated interactions for TPGS1 Gene

Drugs & Compounds for TPGS1 Gene

No Compound Related Data Available

Transcripts for TPGS1 Gene

mRNA/cDNA for TPGS1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(35) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TPGS1 Gene

Tubulin polyglutamylase complex subunit 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPGS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPGS1 Gene

No ASD Table

Relevant External Links for TPGS1 Gene

GeneLoc Exon Structure for
TPGS1
ECgene alternative splicing isoforms for
TPGS1

Expression for TPGS1 Gene

mRNA expression in normal human tissues for TPGS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TPGS1 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPGS1 Gene



SOURCE GeneReport for Unigene cluster for TPGS1 Gene Hs.369613

genes like me logo Genes that share expression patterns with TPGS1: view

Protein tissue co-expression partners for TPGS1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TPGS1 Gene

Orthologs for TPGS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TPGS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TPGS1 35
  • 87.82 (n)
  • 87.24 (a)
TPGS1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPGS1 35
  • 88.74 (n)
  • 87.24 (a)
TPGS1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tpgs1 35
  • 83.79 (n)
  • 86.21 (a)
Tpgs1 16
Tpgs1 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tpgs1 35
  • 82.53 (n)
  • 86.21 (a)
oppossum
(Monodelphis domestica)
Mammalia TPGS1 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves TPGS1 35
  • 68.86 (n)
  • 66.06 (a)
TPGS1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tpgs1 35
  • 57.33 (n)
  • 57.09 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3143 35
zebrafish
(Danio rerio)
Actinopterygii CR774186.2 36
  • 37 (a)
OneToMany
TPGS1 (1 of 2) 36
  • 39 (a)
OneToMany
Species with no ortholog for TPGS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TPGS1 Gene

ENSEMBL:
Gene Tree for TPGS1 (if available)
TreeFam:
Gene Tree for TPGS1 (if available)

Paralogs for TPGS1 Gene

No data available for Paralogs for TPGS1 Gene

Variants for TPGS1 Gene

Sequence variations from dbSNP and Humsavar for TPGS1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2304245 -- 519,749(+) CGGCG(A/G)CTGGA downstream-variant-500B
rs3745924 -- 511,453(-) TATTT(C/T)GGGCT intron-variant
rs4919836 -- 510,326(+) CGAGA(G/T)CGCGC intron-variant
rs4919838 -- 518,686(+) GGGAG(A/G)AGGGA intron-variant
rs4919839 -- 518,718(+) CTTCA(A/G)GGATA intron-variant

Variation tolerance for TPGS1 Gene

Gene Damage Index Score: 4.01; 60.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPGS1 Gene

HapMap Linkage Disequilibrium report
TPGS1
Human Gene Mutation Database (HGMD)
TPGS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TPGS1 Gene

Disorders for TPGS1 Gene

Relevant External Links for TPGS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPGS1
genes like me logo Genes that share disorders with TPGS1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPGS1 Gene

Publications for TPGS1 Gene

  1. Characterisation of PGs1, a subunit of a protein complex co-purifying with tubulin polyglutamylase. (PMID: 12972506) Regnard C. … EddAc B. (J. Cell. Sci. 2003) 2 67
  2. Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. (PMID: 11441184) Dehal P. … Stubbs L. (Science 2001) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 67
  5. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 67

Products for TPGS1 Gene

Sources for TPGS1 Gene

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