TPD52L3 Gene
protein-coding GIFtS: 44
GCID: GC09P006319
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tumor protein D52-like 3
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Aliases
for TPD52L3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tumor Protein D52-Like 31 2 3 | | NYDSP252 | | Testis Development Protein NYD-SP252 3 | | Protein Kinase NYD-SP252 | | HD551 | | Tumor Protein D552 | | NYD-SP251 | | |
Export aliases for TPD52L3 gene to outside databases |
Summaries
for TPD52L3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TPD52L3:
This gene encodes a member of the tumor protein D52-like family of proteins. These proteins are characterized by anN-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-likeproteins. The encoded protein may play a role in spermatogenesis. Alternative splicing results in multiple transcriptvariants. (provided by RefSeq, Oct 2009)
|
Genomic Views
for TPD52L3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TPD52L3 gene promoter:
E2F-3a E2F-4 E2F-5 ATF-2 E2F-2 Evi-1 CRE-BP1 c-Rel E2F-1 E2F
Other transcription factors
Search SABiosciences Chromatin IP Primers for TPD52L3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPD52L3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p24.1 Ensembl cytogenetic band: 9p24.1 HGNC cytogenetic band: 9p24.1TPD52L3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P006319: view genomic region
(about GC identifiers)
Start:
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6,328,349 bp from pter |
End:
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6,331,900 bp from pter |
Size:
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3,552 bases |
Orientation:
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plus strand |
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Proteins
for TPD52L3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TPD55_HUMAN, Q96J77 (See
protein sequence)Recommended Name: Tumor protein D55 Size: 140 amino acids; 15503 Da
Secondary accessions: Q5TCR3 Q5TCR4 Q5TCR5 Q8N4P5 Q8WWF7 Q96M09Alternative splicing: 3 isoforms: Q96J77-1 Q96J77-2 Q96J77-3 Explore the universe of human proteins at neXtProt for TPD52L3: NX_Q96J77
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96J77
TPD52L3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001001874.1 NP_001001875.1 NP_277051.3
ENSEMBL proteins: ENSP00000370836 ENSP00000318665 ENSP00000341677
Human Recombinant Protein Products:
TPD52L3 Antibody Products:
Assay Products for TPD52L3: |
Protein
Domains /
Families
for TPD52L3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TPD52L3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96J77ProtoNet protein and cluster: Q96J77 1 Blocks protein family: IPB007327 Tumor protein D52
UniProtKB/Swiss-Prot: TPD55_HUMAN, Q96J77Similarity: Belongs to the TPD52 family |
Function
for TPD52L3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPD52L3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPD52L3 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPD52L3 |
2 GenomeRNAi human phenotypes for TPD52L3:
|
Pathways & Interactions
for TPD52L3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TPD52L3
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/7 Interacting proteins for TPD52L3 (Q96J772, 3 ENSP000003416774) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
|
Drugs & Compounds
for TPD52L3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TPD52L3
Search CenterWatch for drugs/clinical trials and news about TPD52L3 / TPD55
|
Transcripts
for TPD52L3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TPD52L3 gene (3 alternative transcripts): NM_001001874.2 NM_001001875.3 NM_033516.5 Unigene Cluster for TPD52L3: Tumor protein D52-like 3 Hs.351815 [show with all ESTs]Unigene Representative Sequence: NM_0335163 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000381428(uc003zjv.3) ENST00000314556(uc003zjx.2) ENST00000344545(uc003zjw.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPD52L3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPD52L3 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): TPD52L3 (NM_001001874) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TPD52L3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPD52L3 |
Additional cDNA sequence: AK057479.1 AY032877.1 BC017589.2 BC033792.1 BC042113.1 4 DOTS entries: DT.95268544 DT.100752307 DT.40119521 DT.121163762 24/30 AceView cDNA sequences (see all 30): NM_001001875 AA789271 BC017589 BC042113 BX089696 NM_001001874 AI809924 AA411964 AI024918 AA416988 BP371244 AA757197 BI826146 BG718156 BC033792 AI962433 AI032390 AI028342 BI519930 BI828707 BG772945 AW206997 AI024253 AI041556
GeneLoc Exon Structure
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Expression
for TPD52L3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TPD52L3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAGGACAGA
About this image
See TPD52L3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TPD52L3
SOURCE GeneReport for Unigene cluster: Hs.351815
UniProtKB/Swiss-Prot: TPD55_HUMAN, Q96J77Tissue specificity: Specifically expressed in testis. Expressed at 5.6-fold higher levels in adult testis than in fetaltestis
SABiosciences Custom PCR Arrays for TPD52L3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TPD52L3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TPD52L3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPD52L3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPD52L3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPD52L3 |
Orthologs
for TPD52L3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TPD52L3 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for TPD52L3 (if available)
TreeFam Gene Tree for TPD52L3 (if available) |
Paralogs
for TPD52L3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TPD52L3 gene
- TPD52L22 TPD522 TPD52L12
5 SIMAP similar genes for TPD52L3 using alignment to 1 protein entry: TPD55_HUMAN:DKFZp686A1765 TPD52 TPD52L1 PrLZ TPD52L2
TPD52L3 for paralogs About GeneDecksing
|
Genomic Variants
for TPD52L3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TPD52L3 (6328349 - 6331900 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TPD52L3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPD52L3 |
|
Disorders
/ Diseases
for TPD52L3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TPD52L3 for disorders About MalaCards
TPD52L3 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: TPD52L3 (1 document)
Export disorders for TPD52L3 gene to outside databases
|
Publications
for TPD52L3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TPD52L3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TPD52L3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins. (PubMed id 16631610)1, 2 Cao Q.... Li J. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TPD52L3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TPD52L3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TPD52L3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TPD52L3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TPD52L3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TPD52L3 gene:
Search GeneIP for patents involving TPD52L3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TPD52L3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for TPD52L3 | | OriGene shRNA RFP for TPD52L3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TPD52L3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TPD52L3 | | | OriGene Protein Over-expression Lysate for TPD52L3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TPD52L3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPD52L3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPD52L3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 |  |  |  | |
| | | | Search Tocris compounds for TPD52L3 |
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 | | | TPD52L3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPD52L3 |
|  |  |  | | | | Search ThermoFisher Antibodies for TPD52L3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPD52L3 |
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