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Aliases for TPD52L3 Gene

Aliases for TPD52L3 Gene

  • Tumor Protein D52-Like 3 2 3 4 5
  • Testis Development Protein NYD-SP25 3 4
  • HD55 3 4
  • Testis Tissue Sperm-Binding Protein Li 87P 3
  • Protein Kinase NYD-SP25 3
  • NYDSP25 3

External Ids for TPD52L3 Gene

Summaries for TPD52L3 Gene

Entrez Gene Summary for TPD52L3 Gene

  • This gene encodes a member of the tumor protein D52-like family of proteins. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. The encoded protein may play a role in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for TPD52L3 Gene

TPD52L3 (Tumor Protein D52-Like 3) is a Protein Coding gene. An important paralog of this gene is TPD52L2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPD52L3 Gene

Genomics for TPD52L3 Gene

Regulatory Elements for TPD52L3 Gene

Enhancers for TPD52L3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TPD52L3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TPD52L3 Gene

Chromosome:
9
Start:
6,328,349 bp from pter
End:
6,331,900 bp from pter
Size:
3,552 bases
Orientation:
Plus strand

Genomic View for TPD52L3 Gene

Genes around TPD52L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPD52L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPD52L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPD52L3 Gene

Proteins for TPD52L3 Gene

  • Protein details for TPD52L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96J77-TPD55_HUMAN
    Recommended name:
    Tumor protein D55
    Protein Accession:
    Q96J77
    Secondary Accessions:
    • Q5TCR3
    • Q5TCR4
    • Q5TCR5
    • Q8N4P5
    • Q8WWF7
    • Q96M09

    Protein attributes for TPD52L3 Gene

    Size:
    140 amino acids
    Molecular mass:
    15503 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TPD52L3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPD52L3 Gene

Proteomics data for TPD52L3 Gene at MOPED

Post-translational modifications for TPD52L3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TPD52L3 Gene

No data available for DME Specific Peptides for TPD52L3 Gene

Domains & Families for TPD52L3 Gene

Protein Domains for TPD52L3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TPD52L3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96J77

UniProtKB/Swiss-Prot:

TPD55_HUMAN :
  • Belongs to the TPD52 family.
Family:
  • Belongs to the TPD52 family.
genes like me logo Genes that share domains with TPD52L3: view

No data available for Gene Families for TPD52L3 Gene

Function for TPD52L3 Gene

genes like me logo Genes that share phenotypes with TPD52L3: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPD52L3 Gene

Localization for TPD52L3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPD52L3 Gene COMPARTMENTS Subcellular localization image for TPD52L3 gene
Compartment Confidence
cytosol 3
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TPD52L3 Gene

Pathways & Interactions for TPD52L3 Gene

SuperPathways for TPD52L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TPD52L3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TPD52L3 Gene

Drugs & Compounds for TPD52L3 Gene

No Compound Related Data Available

Transcripts for TPD52L3 Gene

Unigene Clusters for TPD52L3 Gene

Tumor protein D52-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPD52L3 Gene

No ASD Table

Relevant External Links for TPD52L3 Gene

GeneLoc Exon Structure for
TPD52L3
ECgene alternative splicing isoforms for
TPD52L3

Expression for TPD52L3 Gene

mRNA expression in normal human tissues for TPD52L3 Gene

mRNA differential expression in normal tissues according to GTEx for TPD52L3 Gene

This gene is overexpressed in Testis (x52.5).

Protein differential expression in normal tissues from HIPED for TPD52L3 Gene

This gene is overexpressed in Pancreatic juice (58.8) and Breast (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TPD52L3 Gene



SOURCE GeneReport for Unigene cluster for TPD52L3 Gene Hs.351815

mRNA Expression by UniProt/SwissProt for TPD52L3 Gene

Q96J77-TPD55_HUMAN
Tissue specificity: Specifically expressed in testis. Expressed at 5.6-fold higher levels in adult testis than in fetal testis.
genes like me logo Genes that share expression patterns with TPD52L3: view

Protein tissue co-expression partners for TPD52L3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TPD52L3 Gene

Orthologs for TPD52L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPD52L3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TPD52L3 35
  • 82.35 (n)
  • 76.47 (a)
TPD52L3 36
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPD52L3 35
  • 75 (n)
  • 69.12 (a)
TPD52L3 36
  • 41 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trpd52l3 35
  • 78.27 (n)
  • 68.89 (a)
Trpd52l3 16
Trpd52l3 36
  • 41 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TPD52L3 35
  • 99.52 (n)
  • 99.29 (a)
TPD52L3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tpd52l3 35
  • 79.04 (n)
  • 68.94 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
OneToMany
chicken
(Gallus gallus)
Aves TPD52L2 36
  • 38 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii tpd52l2a 36
  • 27 (a)
ManyToMany
tpd52l2b 36
  • 33 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5174 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F13E6.1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9626 36
  • 25 (a)
OneToMany
Species with no ortholog for TPD52L3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TPD52L3 Gene

ENSEMBL:
Gene Tree for TPD52L3 (if available)
TreeFam:
Gene Tree for TPD52L3 (if available)

Paralogs for TPD52L3 Gene

Paralogs for TPD52L3 Gene

(4) SIMAP similar genes for TPD52L3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TPD52L3: view

Variants for TPD52L3 Gene

Sequence variations from dbSNP and Humsavar for TPD52L3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs3847262 - 6,328,947(+) CCACA(C/T)TCAGA reference, missense
rs898673 -- 6,329,888(+) TCTTT(A/G)TATAT intron-variant, utr-variant-3-prime
rs1037885 -- 6,330,915(+) ACTCC(A/G)TAAAA intron-variant, utr-variant-3-prime
rs1052335 -- 6,330,380(+) ATAGA(A/C)GTTTG intron-variant, utr-variant-3-prime
rs7864863 -- 6,326,763(+) gcctc(A/G)gcctc upstream-variant-2KB

Variation tolerance for TPD52L3 Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.35% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TPD52L3 Gene

Disorders for TPD52L3 Gene

Relevant External Links for TPD52L3

Genetic Association Database (GAD)
TPD52L3
Human Genome Epidemiology (HuGE) Navigator
TPD52L3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPD52L3

No disorders were found for TPD52L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPD52L3 Gene

Publications for TPD52L3 Gene

  1. A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins. (PMID: 16631610) Cao Q. … Li J. (Biochem. Biophys. Res. Commun. 2006) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Genome-wide association study of periodontal pathogen colonization. (PMID: 22699663) Divaris K. … Offenbacher S. (J. Dent. Res. 2012) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for TPD52L3 Gene

Sources for TPD52L3 Gene

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