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Aliases for TPD52L3 Gene

Aliases for TPD52L3 Gene

  • Tumor Protein D52-Like 3 2 3 4
  • Testis Development Protein NYD-SP25 3 4
  • HD55 3 4
  • Protein Kinase NYD-SP25 3
  • Tumor Protein D55 3
  • NYDSP25 3

External Ids for TPD52L3 Gene

Summaries for TPD52L3 Gene

Entrez Gene Summary for TPD52L3 Gene

  • This gene encodes a member of the tumor protein D52-like family of proteins. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. The encoded protein may play a role in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for TPD52L3 Gene

TPD52L3 (Tumor Protein D52-Like 3) is a Protein Coding gene. An important paralog of this gene is TPD52L2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPD52L3 Gene

Genomics for TPD52L3 Gene

Genomic Location for TPD52L3 Gene

Start:
6,328,349 bp from pter
End:
6,331,900 bp from pter
Size:
3,552 bases
Orientation:
Plus strand

Genomic View for TPD52L3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPD52L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPD52L3 Gene

Regulatory Elements for TPD52L3 Gene

Proteins for TPD52L3 Gene

  • Protein details for TPD52L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96J77-TPD55_HUMAN
    Recommended name:
    Tumor protein D55
    Protein Accession:
    Q96J77
    Secondary Accessions:
    • Q5TCR3
    • Q5TCR4
    • Q5TCR5
    • Q8N4P5
    • Q8WWF7
    • Q96M09

    Protein attributes for TPD52L3 Gene

    Size:
    140 amino acids
    Molecular mass:
    15503 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TPD52L3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPD52L3 Gene

Proteomics data for TPD52L3 Gene at MOPED

Post-translational modifications for TPD52L3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TPD52L3 Gene

No data available for DME Specific Peptides for TPD52L3 Gene

Domains for TPD52L3 Gene

Protein Domains for TPD52L3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TPD55_HUMAN
Family:
  • Belongs to the TPD52 family.:
    • Q96J77
genes like me logo Genes that share domains with TPD52L3: view

No data available for Gene Families for TPD52L3 Gene

Function for TPD52L3 Gene

Gene Ontology (GO) - Molecular Function for TPD52L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TPD52L3: view

Phenotypes for TPD52L3 Gene

GenomeRNAi human phenotypes for TPD52L3:
genes like me logo Genes that share phenotypes with TPD52L3: view

miRNA for TPD52L3 Gene

miRTarBase miRNAs that target TPD52L3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TPD52L3 Gene

Localization for TPD52L3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPD52L3 Gene COMPARTMENTS Subcellular localization image for TPD52L3 gene
Compartment Confidence
cytosol 3
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for TPD52L3 Gene

Pathways for TPD52L3 Gene

SuperPathways for TPD52L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TPD52L3 Gene

None

No data available for Pathways by source for TPD52L3 Gene

Transcripts for TPD52L3 Gene

Unigene Clusters for TPD52L3 Gene

Tumor protein D52-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPD52L3 Gene

No ASD Table

Relevant External Links for TPD52L3 Gene

GeneLoc Exon Structure for
TPD52L3
ECgene alternative splicing isoforms for
TPD52L3

Expression for TPD52L3 Gene

mRNA expression in normal human tissues for TPD52L3 Gene

mRNA differential expression in normal tissues according to GTEx for TPD52L3 Gene

This gene is overexpressed in Testis (52.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TPD52L3 Gene

SOURCE GeneReport for Unigene cluster for TPD52L3 Gene Hs.351815

mRNA Expression by UniProt/SwissProt for TPD52L3 Gene

Q96J77-TPD55_HUMAN
Tissue specificity: Specifically expressed in testis. Expressed at 5.6-fold higher levels in adult testis than in fetal testis.
genes like me logo Genes that share expressions with TPD52L3: view

Orthologs for TPD52L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPD52L3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPD52L3 36
  • 99.52 (n)
  • 99.29 (a)
TPD52L3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TPD52L3 36
  • 82.35 (n)
  • 76.47 (a)
TPD52L3 37
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPD52L3 36
  • 75 (n)
  • 69.12 (a)
TPD52L3 37
  • 41 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trpd52l3 36
  • 78.27 (n)
  • 68.89 (a)
Trpd52l3 16
Trpd52l3 37
  • 41 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 37 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 31 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tpd52l3 36
  • 79.04 (n)
  • 68.94 (a)
chicken
(Gallus gallus)
Aves TPD52L2 37
  • 38 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 36 (a)
ManyToMany
-- 37
  • 31 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii tpd52l2a 37
  • 27 (a)
ManyToMany
tpd52l2b 37
  • 33 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5174 37
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F13E6.1 37
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9626 37
  • 25 (a)
OneToMany
Species with no ortholog for TPD52L3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TPD52L3 Gene

ENSEMBL:
Gene Tree for TPD52L3 (if available)
TreeFam:
Gene Tree for TPD52L3 (if available)

Paralogs for TPD52L3 Gene

Paralogs for TPD52L3 Gene

Selected SIMAP similar genes for TPD52L3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TPD52L3: view

Variants for TPD52L3 Gene

Sequence variations from dbSNP and Humsavar for TPD52L3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs898673 -- 6,329,888(+) TCTTT(A/G)TATAT intron-variant, utr-variant-3-prime
rs1037885 -- 6,330,915(+) ACTCC(A/G)TAAAA intron-variant, utr-variant-3-prime
rs1052335 -- 6,330,380(+) ATAGA(A/C)GTTTG intron-variant, utr-variant-3-prime
rs2290913 -- 6,330,321(+) CATTT(A/T)CAAAA intron-variant, utr-variant-3-prime
rs2295843 -- 6,328,871(+) AAACA(A/G)AAGAC synonymous-codon, reference

Relevant External Links for TPD52L3 Gene

HapMap Linkage Disequilibrium report
TPD52L3

No data available for Structural Variations from Database of Genomic Variants (DGV) for TPD52L3 Gene

Disorders for TPD52L3 Gene

Relevant External Links for TPD52L3

Genetic Association Database (GAD)
TPD52L3
Human Genome Epidemiology (HuGE) Navigator
TPD52L3
genes like me logo Genes that share disorders with TPD52L3: view

No data available for UniProtKB/Swiss-Prot for TPD52L3 Gene

Publications for TPD52L3 Gene

  1. A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins. (PMID: 16631610) Cao Q. … Li J. (Biochem. Biophys. Res. Commun. 2006) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TPD52L3 Gene

Sources for TPD52L3 Gene

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