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TPD52L2 Gene

protein-coding   GIFtS: 56
GCID: GC20P062490

Tumor Protein D52-Like 2

  See TPD52L2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Tumor Protein D52-Like 21 2 3
D542
HCCR-Binding Protein 22
Tumor Protein D542
hD543

External Ids:    HGNC: 120071   Entrez Gene: 71652   Ensembl: ENSG000001011507   OMIM: 6037475   UniProtKB: O433993   
ORGUL members:         

Export aliases for TPD52L2 gene to outside databases

Previous GC identifers: GC20P062374 GC20P063175 GC20P063222 GC20P061967 GC20P059229


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TPD52L2 Gene:
This gene encodes a member of the tumor protein D52-like family. These proteins are characterized by an N-terminal
coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like
proteins. Expression of this gene may be a marker for breast cancer and acute lymphoblastic leukemia.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a
pseudogene of this gene is located on the long arm of chromosome 12. (provided by RefSeq, Aug 2011)

GeneCards Summary for TPD52L2 Gene:
TPD52L2 (tumor protein D52-like 2) is a protein-coding gene. Diseases associated with TPD52L2 include lymphoblastic leukemia, and breast cancer. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is TPD52L3.

Gene Wiki entry for TPD52L2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the TPD52L2 gene promoter:
         Max1   AhR   Bach2   Arnt   GATA-1   SRY   POU2F1   POU2F1a   HOXA5   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTPD52L2 promoter sequence
   Search Chromatin IP Primers for TPD52L2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPD52L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.2-q13.3   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.2-q13.3

TPD52L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPD52L2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P062490:  view genomic region     (about GC identifiers)

Start:
62,496,590 bp from pter      End:
62,522,898 bp from pter
Size:
26,309 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TPD54_HUMAN, O43399 (See protein sequence)
Recommended Name: Tumor protein D54  
Size: 206 amino acids; 22238 Da
Subunit: Forms a homodimer or heterodimer with other members of the family (By similarity). Interacts with MAL2
Sequence caution: Sequence=BU165202; Type=Frameshift; Positions=155, 157, 173, 188;
Secondary accessions: B4DPJ6 E1P5G7 O43398 Q5JWU5 Q5JWU6 Q5JWU8 Q5U0E0 Q9H3Z6
Alternative splicing: 7 isoforms:  O43399-1   O43399-2   O43399-3   O43399-4   O43399-5   O43399-6   O43399-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TPD52L2: NX_O43399

Explore proteomics data for TPD52L2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys90, Lys108, Lys128, Lys139
  • Modification sites at PhosphoSitePlus

  • See TPD52L2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (10 alternative transcripts): 
    NP_001230820.1  NP_001230821.1  NP_001230823.1  NP_001230824.1  NP_003279.2  NP_955391.1  NP_955392.1  NP_955393.1  
    NP_955394.1  NP_955395.1  

    ENSEMBL proteins: 
     ENSP00000358943   ENSP00000343547   ENSP00000343554   ENSP00000344647   ENSP00000340006  
     ENSP00000217121   ENSP00000351350  

    TPD52L2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007327 TPD52

    Graphical View of Domain Structure for InterPro Entry O43399

    ProtoNet protein and cluster: O43399

    1 Blocks protein domain: IPB007327 Tumor protein D52

    UniProtKB/Swiss-Prot: TPD54_HUMAN, O43399
    Similarity: Belongs to the TPD52 family


    Find genes that share domains with TPD52L2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for TPD52L2:
    tumor protein D52 like 2,signaling molecule,regulator of cell proliferation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12963375
    GO:0042803protein homodimerization activity IDA9484778
    GO:0044822poly(A) RNA binding IDA--
    GO:0046982protein heterodimerization activity IDA9484778
         
    Find genes that share ontologies with TPD52L2           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tpd52l2):
     growth/size/body 

    Find genes that share phenotypes with TPD52L2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TPD52L2
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    miRNA
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    miRTarBase miRNAs that target TPD52L2:
    hsa-mir-93-3p (MIRT038782), hsa-mir-26b-5p (MIRT029516), hsa-let-7b-5p (MIRT052308), hsa-mir-124-3p (MIRT022716), hsa-mir-1 (MIRT023790), hsa-mir-122-5p (MIRT003100), hsa-mir-29b-3p (MIRT048372), hsa-let-7d-5p (MIRT051715)

    Block miRNA regulation of human, mouse, rat TPD52L2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TPD52L2 (see all 21):
    hsa-miR-3910 hsa-miR-485-5p hsa-miR-217 hsa-miR-320a hsa-miR-4251 hsa-miR-539 hsa-miR-128 hsa-miR-181a-2*
    SwitchGear 3'UTR luciferase reporter plasmidTPD52L2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TPD52L2

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    Sino Biological Human cDNA Clone for TPD52L2
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPD52L2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA16112108
    GO:0048471perinuclear region of cytoplasm IDA16112108

    Find genes that share ontologies with TPD52L2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TPD52L2
    Interactions:

        Search GeneGlobe Interaction Network for TPD52L2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TPD52L2 (O433991, 3 ENSP000002171214) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TPD52P553273, ENSP000003683914I2D: score=3 STRING: ENSP00000368391
    TPD52L1Q168903, ENSP000003573874I2D: score=2 STRING: ENSP00000357387
    IKBKEQ141643, ENSP000003560874I2D: score=1 STRING: ENSP00000356087
    YWHAGP619813I2D: score=2 
    MAL2Q969L23I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042127regulation of cell proliferation TAS9484778

    Find genes that share ontologies with TPD52L2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TPD52L2 (TPD54)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TPD52L2 gene (10 alternative transcripts): 
    NM_001243891.1  NM_001243892.1  NM_001243894.1  NM_001243895.1  NM_003288.3  NM_199359.2  NM_199360.2  NM_199361.2  
    NM_199362.2  NM_199363.2  

    Unigene Cluster for TPD52L2:

    Tumor protein D52-like 2
    Hs.473296  [show with all ESTs]
    Unigene Representative Sequence: AK125263
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369927 ENST00000346249(uc021wgg.1 uc011abk.2 uc002yhc.3 uc021wgh.1 uc021wgi.1)
    ENST00000348257(uc021wgf.1 uc011abl.2 uc002yhd.3) ENST00000352482(uc002ygz.3 uc002yhb.3)
    ENST00000351424(uc002yha.3) ENST00000217121(uc002ygy.3) ENST00000358548
    ENST00000474176
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TPD52L2 (see all 21):
    hsa-miR-3910 hsa-miR-485-5p hsa-miR-217 hsa-miR-320a hsa-miR-4251 hsa-miR-539 hsa-miR-128 hsa-miR-181a-2*
    SwitchGear 3'UTR luciferase reporter plasmidTPD52L2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TPD52L2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TPD52L2
      QuantiTect SYBR Green Assays in human, mouse, rat TPD52L2
      QuantiFast Probe-based Assays in human, mouse, rat TPD52L2

    Additional mRNA sequence: 

    AB062396.1 AF004429.1 AF004430.1 AK055068.1 AK125263.1 AK223031.1 AK293349.1 AK297064.1 
    AK298366.1 AK314501.1 AY323819.1 BC006804.1 BT019631.1 CR542036.1 CR749208.1 NR_045090.1 

    Selected DOTS entries (see all 37):

    DT.87017389  DT.92451629  DT.100835060  DT.102832714  DT.120804051  DT.100835063  DT.100675761  DT.95370929 
    DT.91878355  DT.120803891  DT.120803987  DT.102832712  DT.95370935  DT.95236474  DT.100835064  DT.120803884 
    DT.120804015  DT.100835068  DT.92451638  DT.95261728  DT.120804009  DT.92018018  DT.100043991  DT.100044776 

    Selected AceView cDNA sequences (see all 522):

    NM_003288 BQ432368 CA489797 NM_199363 BQ690893 BM918020 BQ948007 AW439219 
    BM695445 BM556020 BQ051193 BU540767 BP345008 BE673173 BM744515 R06254 
    BQ938494 CB130947 BM753697 BU174932 CB128965 BM424093 BQ433027 CR600606 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TPD52L2 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^
    SP1:                                            -                                                     -                             -     -     -     -         
    SP2:                                            -                                                     -     -     -                 -     -     -               
    SP3:                                            -                                                     -                 -           -     -     -     -         
    SP4:                                            -                 -                                   -                             -     -     -     -         
    SP5:                                                                                                  -     -     -                 -           -               

    ExUns: 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h · 10i ^ 11a · 11b · 11c
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for TPD52L2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TPD52L2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGATGGCG
    TPD52L2 Expression
    About this image


    TPD52L2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Adipose (Muscoskeletal System)
     
     Esophagus (Gastrointestinal Tract)
     
     Adrenal Gland (Endocrine System)
     
     Placenta (Extraembryonic Tissues)
    TPD52L2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TPD52L2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.473296
        Custom PCR Arrays for TPD52L2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPD52L2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TPD52L2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tpd52l21 , 5 tumor protein D52-like 21, 5 88.64(n)1
    91.36(a)1
      2 (103.63 cM)5
    663141  NM_025482.21  NP_079758.21 
     1814971425 
    chicken
    (Gallus gallus)
    Aves TPD52L21 tumor protein D52-like 2 76.59(n)
    80(a)
      419257  NM_001030858.1  NP_001026029.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    75(a)
    70(a)
    many ↔ many
    many ↔ many
    4(156248158-156284239)
    1(107626725-107627363)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.23912 Xenopus laevis transcribed sequence with weak similarity more 77.24(n)    48025886 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045297.12   -- 75.93(n)   322103  BC045297.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51746
    --
    18(a)
    1 → many
    2R(14308915-14313732)
    worm
    (Caenorhabditis elegans)
    Secernentea F13E6.16
    Protein F13E6.1 (F13E6.1) mRNA, complete cds
    32(a)
    1 → many
    X(10675699-10677109) WBGene00008745


    ENSEMBL Gene Tree for TPD52L2 (if available)
    TreeFam Gene Tree for TPD52L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TPD52L2 gene
    TPD52L32  TPD522  TPD52L12  
    4 SIMAP similar genes for TPD52L2 using alignment to 2 protein entries:     TPD54_HUMAN (see all proteins):
    DKFZp686A1765    TPD52    TPD52L1    TPD52L3

    Find genes that share paralogs with TPD52L2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TPD52L2
    PGOHUM00000239961


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TPD52L2 (see all 682)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1507774391,2
    Cuntested162478577(+) CAAGTC/TGTTTG 20 S L mis1 int10--------
    rs1407889341,2
    C--62452809(+) AGGAGA/GACATT 11 -- us2k10--------
    rs1859563441,2
    --62452821(+) GCATGA/GCAGGG 11 -- us2k10--------
    rs1998659691,2
    C--62452978(+) CAGAT-/AACACT 11 -- us2k10--------
    rs1116145791,2
    C,F--62453095(+) CAATGG/ATCTGT 11 -- us2k12Minor allele frequency- A:0.04CSA WA 120
    rs1501055781,2
    --62453170(+) CTAGTC/TCCCGG 11 -- us2k10--------
    rs1385948821,2
    --62453212(+) GGAAAC/GAATGA 11 -- us2k10--------
    rs1912532081,2
    --62453305(+) AGTACC/GAGGAA 11 -- us2k10--------
    rs744324251,2
    C,F--62453334(+) TGGCCG/AGGTGA 11 -- us2k11Minor allele frequency- A:0.11WA 118
    rs1825048691,2
    C--62453374(+) CCTAGG/TGACCA 11 -- us2k10--------

    HapMap Linkage Disequilibrium report for TPD52L2 (62496590 - 62522898 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TPD52L2 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722983CNV Deletion23290073
    esv2722986CNV Deletion23290073
    esv2722985CNV Deletion23290073
    esv2722982CNV Deletion23290073
    nsv509784CNV Insertion20534489
    nsv913250CNV Loss21882294
    nsv913190CNV Loss21882294
    nsv913267CNV Loss21882294
    dgv4648n71CNV Loss21882294
    nsv828804CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TPD52L2
    DNA2.0 Custom Variant and Variant Library Synthesis for TPD52L2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603747    OMIM disorders: --

    2 diseases for TPD52L2:    
    About MalaCards
    lymphoblastic leukemia    breast cancer

    1 disease from the University of Copenhagen DISEASES database for TPD52L2:
    Collecting duct carcinoma

    Find genes that share disorders with TPD52L2           About GenesLikeMe

    3 Novoseek inferred disease relationships for TPD52L2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast carcinoma 60.1 1 9838088 (1)
    breast cancer 27.3 1 18698023 (1)
    tumors 18.3 2 15337753 (1), 16637015 (1)


    Export disorders for TPD52L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TPD52L2 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with TPD52L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a third member of the D52 gene family indicates alternative coding sequence usage in D52-like transcripts. (PubMed id 9838088)1, 2, 9 Nourse C.R.... Byrne J.A. (Biochim. Biophys. Acta 1998)
    2. Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system. (PubMed id 9484778)1, 3, 9 Byrne J.A.... Gunning P. (Oncogene 1998)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system. (PubMed id 11549320)1, 2 Wilson S.H.D.... Byrne J.A. (Genomics 2001)
    8. A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins. (PubMed id 16631610)1, 9 Cao Q.... Li J. (Biochem. Biophys. Res. Commun. 2006)
    9. Nonredundant functions for tumor protein D52-like proteins support specific targeting of TPD52. (PubMed id 18698023)1, 9 Shehata M....Byrne J.A. (Clin. Cancer Res. 2008)
    10. 14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation. (PubMed id 23444366)1 Ichimura T....Hachiya N. (J. Cell. Sci. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7165 HGNC: 12007 AceView: TPD52L2 Ensembl:ENSG00000101150 euGenes: HUgn7165
    ECgene: TPD52L2 H-InvDB: TPD52L2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TPD52L2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TPD52L2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TPD52L2 gene:
    Search GeneIP for patents involving TPD52L2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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