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Aliases for TPD52L2 Gene

Aliases for TPD52L2 Gene

  • Tumor Protein D52-Like 2 2 3 4
  • HCCR-Binding Protein 2 3
  • Tumor Protein D54 3
  • TPD54 3
  • HD54 4
  • D54 3

External Ids for TPD52L2 Gene

Previous GeneCards Identifiers for TPD52L2 Gene

  • GC20P062374
  • GC20P063175
  • GC20P063222
  • GC20P061967
  • GC20P062490
  • GC20P059229

Summaries for TPD52L2 Gene

Entrez Gene Summary for TPD52L2 Gene

  • This gene encodes a member of the tumor protein D52-like family. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. Expression of this gene may be a marker for breast cancer and acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Aug 2011]

GeneCards Summary for TPD52L2 Gene

TPD52L2 (Tumor Protein D52-Like 2) is a Protein Coding gene. Diseases associated with TPD52L2 include lymphoblastic leukemia and breast cancer. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is TPD52L3.

Gene Wiki entry for TPD52L2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPD52L2 Gene

Genomics for TPD52L2 Gene

Regulatory Elements for TPD52L2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TPD52L2 Gene

Start:
63,865,228 bp from pter
End:
63,891,545 bp from pter
Size:
26,318 bases
Orientation:
Plus strand

Genomic View for TPD52L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPD52L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPD52L2 Gene

Proteins for TPD52L2 Gene

  • Protein details for TPD52L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43399-TPD54_HUMAN
    Recommended name:
    Tumor protein D54
    Protein Accession:
    O43399
    Secondary Accessions:
    • B4DPJ6
    • E1P5G7
    • O43398
    • Q5JWU5
    • Q5JWU6
    • Q5JWU8
    • Q5U0E0
    • Q9H3Z6

    Protein attributes for TPD52L2 Gene

    Size:
    206 amino acids
    Molecular mass:
    22238 Da
    Quaternary structure:
    • Forms a homodimer or heterodimer with other members of the family (By similarity). Interacts with MAL2.
    SequenceCaution:
    • Sequence=BU165202; Type=Frameshift; Positions=155, 157, 173, 188; Evidence={ECO:0000305};

    Alternative splice isoforms for TPD52L2 Gene

neXtProt entry for TPD52L2 Gene

Proteomics data for TPD52L2 Gene at MOPED

Post-translational modifications for TPD52L2 Gene

  • Ubiquitination at Lys90, Lys108, Lys128, and Lys139
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TPD52L2 Gene

Domains for TPD52L2 Gene

Protein Domains for TPD52L2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O43399

UniProtKB/Swiss-Prot:

TPD54_HUMAN :
  • O43399
Family:
  • Belongs to the TPD52 family.
genes like me logo Genes that share domains with TPD52L2: view

No data available for Gene Families for TPD52L2 Gene

Function for TPD52L2 Gene

Molecular function for TPD52L2 Gene

GENATLAS Biochemistry: tumor protein D52 like 2,signaling molecule,regulator of cell proliferation

Gene Ontology (GO) - Molecular Function for TPD52L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12963375
GO:0042803 protein homodimerization activity IDA 9484778
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046982 protein heterodimerization activity IDA 9484778
genes like me logo Genes that share ontologies with TPD52L2: view

Phenotypes for TPD52L2 Gene

MGI mutant phenotypes for TPD52L2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with TPD52L2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPD52L2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TPD52L2 Gene

Localization for TPD52L2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPD52L2 Gene COMPARTMENTS Subcellular localization image for TPD52L2 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TPD52L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16112108
GO:0048471 perinuclear region of cytoplasm IDA 16112108
genes like me logo Genes that share ontologies with TPD52L2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TPD52L2 Gene

Pathways for TPD52L2 Gene

SuperPathways for TPD52L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TPD52L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042127 regulation of cell proliferation TAS 9484778
genes like me logo Genes that share ontologies with TPD52L2: view

No data available for Pathways by source for TPD52L2 Gene

Transcripts for TPD52L2 Gene

Unigene Clusters for TPD52L2 Gene

Tumor protein D52-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPD52L2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPD52L2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - -
SP13: - - - - - - - - - - -
SP14: - - - - - -
SP15: -
SP16:
SP17:

ExUns: 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h · 10i ^ 11a · 11b · 11c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - - - - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for TPD52L2 Gene

GeneLoc Exon Structure for
TPD52L2
ECgene alternative splicing isoforms for
TPD52L2

Expression for TPD52L2 Gene

mRNA expression in normal human tissues for TPD52L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPD52L2 Gene

SOURCE GeneReport for Unigene cluster for TPD52L2 Gene Hs.473296

genes like me logo Genes that share expressions with TPD52L2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TPD52L2 Gene

Orthologs for TPD52L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPD52L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPD52L2 35
  • 99.71 (n)
  • 99.56 (a)
TPD52L2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TPD52L2 35
  • 87.46 (n)
  • 89.25 (a)
TPD52L2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPD52L2 35
  • 90.13 (n)
  • 91.26 (a)
TPD52L2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tpd52l2 35
  • 88.64 (n)
  • 91.36 (a)
Tpd52l2 16
Tpd52l2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tpd52l2 35
  • 88.03 (n)
  • 91.36 (a)
chicken
(Gallus gallus)
Aves TPD52L2 35
  • 76.59 (n)
  • 80 (a)
TPD52L2 36
  • 80 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
ManyToMany
-- 36
  • 75 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.2391 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tpd52l2 35
  • 71.81 (n)
  • 71.5 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2893 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
tpd52l2a 36
  • 57 (a)
ManyToMany
tpd52l2b 35
  • 69.36 (n)
  • 68.18 (a)
tpd52l2b 36
  • 63 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004868 35
  • 48.66 (n)
  • 38.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5174 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F13E6.1 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9626 36
  • 35 (a)
OneToMany
Species with no ortholog for TPD52L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPD52L2 Gene

ENSEMBL:
Gene Tree for TPD52L2 (if available)
TreeFam:
Gene Tree for TPD52L2 (if available)

Paralogs for TPD52L2 Gene

Paralogs for TPD52L2 Gene

Selected SIMAP similar genes for TPD52L2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TPD52L2 Gene

genes like me logo Genes that share paralogs with TPD52L2: view

Variants for TPD52L2 Gene

Sequence variations from dbSNP and Humsavar for TPD52L2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs7000 -- 63,891,113(+) TAAAT(A/G)GTCGC utr-variant-3-prime, nc-transcript-variant
rs8567 -- 63,890,962(+) GGCTC(A/G)CATTC utr-variant-3-prime, nc-transcript-variant
rs731696 -- 63,881,884(+) CATGG(G/T)GGGCC intron-variant
rs752606 -- 63,890,661(+) TTTAT(A/G)TGTAT utr-variant-3-prime, nc-transcript-variant
rs1056861 -- 63,873,717(+) GGAGA(A/G)GCACT missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TPD52L2 Gene

Variant ID Type Subtype PubMed ID
nsv913190 CNV Loss 21882294
nsv428381 CNV Gain+Loss 18775914
nsv913250 CNV Loss 21882294
dgv4648n71 CNV Loss 21882294
nsv913267 CNV Loss 21882294
nsv828804 CNV Loss 20364138
nsv509784 CNV Insertion 20534489
nsv913268 CNV Loss 21882294
nsv913269 CNV Loss 21882294
nsv469773 CNV Gain 16826518
esv2722982 CNV Deletion 23290073
esv2722983 CNV Deletion 23290073
esv2722985 CNV Deletion 23290073
esv2722986 CNV Deletion 23290073

Relevant External Links for TPD52L2 Gene

HapMap Linkage Disequilibrium report
TPD52L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPD52L2 Gene

Disorders for TPD52L2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for TPD52L2 Gene including...

Search for TPD52L2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TPD52L2 Gene

(3) Novoseek inferred disease relationships for TPD52L2 Gene

Disease -log(P) Hits PubMed IDs
breast carcinoma 60.1 1
breast cancer 27.3 1
tumors 18.3 2
genes like me logo Genes that share disorders with TPD52L2: view

No data available for UniProtKB/Swiss-Prot for TPD52L2 Gene

Publications for TPD52L2 Gene

  1. Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system. (PMID: 9484778) Byrne J.A. … Gunning P. (Oncogene 1998) 2 3 23
  2. Cloning of a third member of the D52 gene family indicates alternative coding sequence usage in D52-like transcripts. (PMID: 9838088) Nourse C.R. … Byrne J.A. (Biochim. Biophys. Acta 1998) 3 4 23
  3. A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins. (PMID: 16631610) Cao Q. … Li J. (Biochem. Biophys. Res. Commun. 2006) 3 23
  4. Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system. (PMID: 11549320) Wilson S.H.D. … Byrne J.A. (Genomics 2001) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for TPD52L2 Gene

Sources for TPD52L2 Gene

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