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Aliases for TPD52L2 Gene

Aliases for TPD52L2 Gene

  • Tumor Protein D52 Like 2 2 3
  • Tumor Protein D52-Like 2 2 3 4 5
  • HCCR-Binding Protein 2 3
  • TPD54 3
  • HD54 4
  • D54 3

External Ids for TPD52L2 Gene

Previous GeneCards Identifiers for TPD52L2 Gene

  • GC20P062374
  • GC20P063175
  • GC20P063222
  • GC20P061967
  • GC20P062490
  • GC20P059229

Summaries for TPD52L2 Gene

Entrez Gene Summary for TPD52L2 Gene

  • This gene encodes a member of the tumor protein D52-like family. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. Expression of this gene may be a marker for breast cancer and acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Aug 2011]

GeneCards Summary for TPD52L2 Gene

TPD52L2 (Tumor Protein D52 Like 2) is a Protein Coding gene. Diseases associated with TPD52L2 include breast cancer. GO annotations related to this gene include poly(A) RNA binding and protein heterodimerization activity. An important paralog of this gene is TPD52L3.

Gene Wiki entry for TPD52L2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPD52L2 Gene

Genomics for TPD52L2 Gene

Regulatory Elements for TPD52L2 Gene

Promoters for TPD52L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TPD52L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TPD52L2 Gene

Chromosome:
20
Start:
63,865,228 bp from pter
End:
63,891,545 bp from pter
Size:
26,318 bases
Orientation:
Plus strand

Genomic View for TPD52L2 Gene

Genes around TPD52L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPD52L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPD52L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPD52L2 Gene

Proteins for TPD52L2 Gene

  • Protein details for TPD52L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43399-TPD54_HUMAN
    Recommended name:
    Tumor protein D54
    Protein Accession:
    O43399
    Secondary Accessions:
    • B4DPJ6
    • E1P5G7
    • O43398
    • Q5JWU5
    • Q5JWU6
    • Q5JWU8
    • Q5U0E0
    • Q9H3Z6

    Protein attributes for TPD52L2 Gene

    Size:
    206 amino acids
    Molecular mass:
    22238 Da
    Quaternary structure:
    • Forms a homodimer or heterodimer with other members of the family (By similarity). Interacts with MAL2.
    SequenceCaution:
    • Sequence=BU165202; Type=Frameshift; Positions=155, 157, 173, 188; Evidence={ECO:0000305};

    Alternative splice isoforms for TPD52L2 Gene

neXtProt entry for TPD52L2 Gene

Proteomics data for TPD52L2 Gene at MOPED

Post-translational modifications for TPD52L2 Gene

  • Ubiquitination at Lys 90, Lys 108, Lys 128, and Lys 139
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TPD52L2 Gene

Domains & Families for TPD52L2 Gene

Protein Domains for TPD52L2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O43399

UniProtKB/Swiss-Prot:

TPD54_HUMAN :
  • Belongs to the TPD52 family.
Family:
  • Belongs to the TPD52 family.
genes like me logo Genes that share domains with TPD52L2: view

No data available for Gene Families for TPD52L2 Gene

Function for TPD52L2 Gene

Molecular function for TPD52L2 Gene

GENATLAS Biochemistry:
tumor protein D52 like 2,signaling molecule,regulator of cell proliferation

Gene Ontology (GO) - Molecular Function for TPD52L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IDA 9484778
GO:0046982 protein heterodimerization activity IDA 9484778
genes like me logo Genes that share ontologies with TPD52L2: view

Phenotypes for TPD52L2 Gene

MGI mutant phenotypes for TPD52L2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with TPD52L2: view

Animal Models for TPD52L2 Gene

MGI Knock Outs for TPD52L2:

Animal Model Products

  • Taconic Biosciences Mouse Models for TPD52L2

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TPD52L2 Gene

Localization for TPD52L2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPD52L2 Gene COMPARTMENTS Subcellular localization image for TPD52L2 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TPD52L2 Gene

Pathways & Interactions for TPD52L2 Gene

SuperPathways for TPD52L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TPD52L2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TPD52L2 Gene

Drugs & Compounds for TPD52L2 Gene

No Compound Related Data Available

Transcripts for TPD52L2 Gene

Unigene Clusters for TPD52L2 Gene

Tumor protein D52-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPD52L2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - -
SP13: - - - - - - - - - - -
SP14: - - - - - -
SP15: -
SP16:
SP17:

ExUns: 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h · 10i ^ 11a · 11b · 11c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - - - - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for TPD52L2 Gene

GeneLoc Exon Structure for
TPD52L2
ECgene alternative splicing isoforms for
TPD52L2

Expression for TPD52L2 Gene

mRNA expression in normal human tissues for TPD52L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TPD52L2 Gene

This gene is overexpressed in Bone marrow stromal cell (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPD52L2 Gene



SOURCE GeneReport for Unigene cluster for TPD52L2 Gene Hs.473296

genes like me logo Genes that share expression patterns with TPD52L2: view

Protein tissue co-expression partners for TPD52L2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TPD52L2 Gene

Orthologs for TPD52L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPD52L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPD52L2 36
  • 100 (a)
OneToOne
TPD52L2 35
  • 99.71 (n)
  • 99.56 (a)
cow
(Bos Taurus)
Mammalia TPD52L2 35
  • 87.46 (n)
  • 89.25 (a)
TPD52L2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPD52L2 36
  • 91 (a)
OneToOne
TPD52L2 35
  • 90.13 (n)
  • 91.26 (a)
mouse
(Mus musculus)
Mammalia Tpd52l2 16
Tpd52l2 36
  • 91 (a)
OneToOne
Tpd52l2 35
  • 88.64 (n)
  • 91.36 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tpd52l2 35
  • 88.03 (n)
  • 91.36 (a)
chicken
(Gallus gallus)
Aves TPD52L2 35
  • 76.59 (n)
  • 80 (a)
TPD52L2 36
  • 80 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
ManyToMany
-- 36
  • 75 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.2391 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tpd52l2 35
  • 71.81 (n)
  • 71.5 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2893 35
zebrafish
(Danio rerio)
Actinopterygii tpd52l2a 36
  • 57 (a)
ManyToMany
tpd52l2b 36
  • 63 (a)
ManyToMany
-- 35
tpd52l2b 35
  • 69.36 (n)
  • 68.18 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004868 35
  • 48.66 (n)
  • 38.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5174 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F13E6.1 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9626 36
  • 35 (a)
OneToMany
Species with no ortholog for TPD52L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPD52L2 Gene

ENSEMBL:
Gene Tree for TPD52L2 (if available)
TreeFam:
Gene Tree for TPD52L2 (if available)

Paralogs for TPD52L2 Gene

Paralogs for TPD52L2 Gene

(4) SIMAP similar genes for TPD52L2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TPD52L2 Gene

genes like me logo Genes that share paralogs with TPD52L2: view

Variants for TPD52L2 Gene

Sequence variations from dbSNP and Humsavar for TPD52L2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1056861 -- 63,873,717(+) GGAGA(A/G)GCACT nc-transcript-variant, reference, missense
rs3795149 -- 63,864,109(+) AGTAG(A/G)AGCCA upstream-variant-2KB
rs3795150 -- 63,864,469(+) CAAAC(C/T)AGCCA upstream-variant-2KB
rs3795151 -- 63,876,668(+) GTTGG(C/T)CTGAA intron-variant
rs3795152 -- 63,884,840(+) GCTCG(C/T)TCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPD52L2 Gene

Variant ID Type Subtype PubMed ID
nsv913190 CNV Loss 21882294
nsv428381 CNV Gain+Loss 18775914
nsv913250 CNV Loss 21882294
dgv4648n71 CNV Loss 21882294
nsv913267 CNV Loss 21882294
nsv828804 CNV Loss 20364138
nsv509784 CNV Insertion 20534489
nsv913268 CNV Loss 21882294
nsv913269 CNV Loss 21882294
nsv469773 CNV Gain 16826518
esv2722982 CNV Deletion 23290073
esv2722983 CNV Deletion 23290073
esv2722985 CNV Deletion 23290073
esv2722986 CNV Deletion 23290073

Variation tolerance for TPD52L2 Gene

Residual Variation Intolerance Score: 37.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPD52L2 Gene

HapMap Linkage Disequilibrium report
TPD52L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPD52L2 Gene

Disorders for TPD52L2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TPD52L2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TPD52L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPD52L2
genes like me logo Genes that share disorders with TPD52L2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPD52L2 Gene

Publications for TPD52L2 Gene

  1. Cloning of a third member of the D52 gene family indicates alternative coding sequence usage in D52-like transcripts. (PMID: 9838088) Nourse C.R. … Byrne J.A. (Biochim. Biophys. Acta 1998) 3 4 23 67
  2. Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system. (PMID: 9484778) Byrne J.A. … Gunning P. (Oncogene 1998) 2 3 23
  3. Nonredundant functions for tumor protein D52-like proteins support specific targeting of TPD52. (PMID: 18698023) Shehata M. … Byrne J.A. (Clin. Cancer Res. 2008) 3 23
  4. A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins. (PMID: 16631610) Cao Q. … Li J. (Biochem. Biophys. Res. Commun. 2006) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for TPD52L2 Gene

Sources for TPD52L2 Gene

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