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Aliases for TPD52L2 Gene

Aliases for TPD52L2 Gene

  • Tumor Protein D52 Like 2 2 3 5
  • Tumor Protein D52-Like 2 2 4
  • HCCR-Binding Protein 2 3
  • Tumor Protein D54 3
  • TPD54 3
  • HD54 4
  • D54 3

External Ids for TPD52L2 Gene

Previous GeneCards Identifiers for TPD52L2 Gene

  • GC20P062374
  • GC20P063175
  • GC20P063222
  • GC20P061967
  • GC20P062490
  • GC20P059229

Summaries for TPD52L2 Gene

Entrez Gene Summary for TPD52L2 Gene

  • This gene encodes a member of the tumor protein D52-like family. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. Expression of this gene may be a marker for breast cancer and acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Aug 2011]

GeneCards Summary for TPD52L2 Gene

TPD52L2 (Tumor Protein D52 Like 2) is a Protein Coding gene. Diseases associated with TPD52L2 include Breast Cancer. GO annotations related to this gene include poly(A) RNA binding and protein heterodimerization activity. An important paralog of this gene is TPD52.

Gene Wiki entry for TPD52L2 Gene

Additional gene information for TPD52L2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPD52L2 Gene

Genomics for TPD52L2 Gene

Regulatory Elements for TPD52L2 Gene

Enhancers for TPD52L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H063625 1.4 ENCODE dbSUPER 11.1 -237.4 -237414 4.8 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A SSRP1 DIDO1 GMEB2 MRGBP CICP4 GID8 RTEL1 TPD52L2 FNDC11 PRPF6 STMN3
GH20H063802 1.1 FANTOM5 Ensembl ENCODE 5.5 -61.5 -61506 1.8 POLR2A MAX MYC SPI1 RGS19 HELZ2 TPD52L2 DNAJC5 OPRL1 ZGPAT GMEB2 PIR49937 PIR52893
GH20H063893 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.5 +31.5 31464 5.4 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF143 DIDO1 UCKL1 MIR647 GMEB2 PRPF6 RGS19 RTEL1 OPRL1 ZBTB46 C20orf181
GH20H063890 0.5 dbSUPER 5.3 +26.1 26101 1.3 POLR2A CEBPG ZBTB33 TPD52L2 DNAJC5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TPD52L2 on UCSC Golden Path with GeneCards custom track

Promoters for TPD52L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000139971 -28 2401 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC

Genomic Locations for TPD52L2 Gene

Genomic Locations for TPD52L2 Gene
26,318 bases
Plus strand

Genomic View for TPD52L2 Gene

Genes around TPD52L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPD52L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPD52L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPD52L2 Gene

Proteins for TPD52L2 Gene

  • Protein details for TPD52L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor protein D54
    Protein Accession:
    Secondary Accessions:
    • B4DPJ6
    • E1P5G7
    • O43398
    • Q5JWU5
    • Q5JWU6
    • Q5JWU8
    • Q5U0E0
    • Q9H3Z6

    Protein attributes for TPD52L2 Gene

    206 amino acids
    Molecular mass:
    22238 Da
    Quaternary structure:
    • Forms a homodimer or heterodimer with other members of the family (By similarity). Interacts with MAL2.
    • Sequence=BU165202; Type=Frameshift; Positions=155, 157, 173, 188; Evidence={ECO:0000305};

    Alternative splice isoforms for TPD52L2 Gene

neXtProt entry for TPD52L2 Gene

Post-translational modifications for TPD52L2 Gene

  • Ubiquitination at Lys90, Lys108, Lys128, and Lys139
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TPD52L2 Gene

Domains & Families for TPD52L2 Gene

Gene Families for TPD52L2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TPD52L2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TPD52 family.
  • Belongs to the TPD52 family.
genes like me logo Genes that share domains with TPD52L2: view

Function for TPD52L2 Gene

Molecular function for TPD52L2 Gene

GENATLAS Biochemistry:
tumor protein D52 like 2,signaling molecule,regulator of cell proliferation

Phenotypes From GWAS Catalog for TPD52L2 Gene

Gene Ontology (GO) - Molecular Function for TPD52L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with TPD52L2: view

Phenotypes for TPD52L2 Gene

MGI mutant phenotypes for TPD52L2:
inferred from 1 alleles
GenomeRNAi human phenotypes for TPD52L2:
genes like me logo Genes that share phenotypes with TPD52L2: view

Animal Models for TPD52L2 Gene

MGI Knock Outs for TPD52L2:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TPD52L2 Gene

Localization for TPD52L2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPD52L2 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TPD52L2 Gene

Pathways & Interactions for TPD52L2 Gene

SuperPathways for TPD52L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TPD52L2 Gene


No data available for Pathways by source and SIGNOR curated interactions for TPD52L2 Gene

Drugs & Compounds for TPD52L2 Gene

(1) Drugs for TPD52L2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenethyl isothiocyanate Investigational Pharma Target 12
genes like me logo Genes that share compounds with TPD52L2: view

Transcripts for TPD52L2 Gene

Unigene Clusters for TPD52L2 Gene

Tumor protein D52-like 2:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPD52L2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - -
SP13: - - - - - - - - - - -
SP14: - - - - - -
SP15: -

ExUns: 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h · 10i ^ 11a · 11b · 11c
SP11: - - - - - - - - -

Relevant External Links for TPD52L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPD52L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPD52L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TPD52L2 Gene

This gene is overexpressed in Bone marrow stromal cell (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TPD52L2 Gene

Protein tissue co-expression partners for TPD52L2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TPD52L2 Gene:


SOURCE GeneReport for Unigene cluster for TPD52L2 Gene:


Evidence on tissue expression from TISSUES for TPD52L2 Gene

  • Nervous system(4.9)
  • Kidney(4.8)
  • Blood(4.5)
  • Liver(4.5)
  • Skin(3.9)
  • Intestine(2.9)
  • Lung(2.4)
  • Eye(2)
  • Pancreas(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with TPD52L2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPD52L2 Gene

Orthologs for TPD52L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPD52L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TPD52L2 33 34
  • 99.71 (n)
(Canis familiaris)
Mammalia TPD52L2 33 34
  • 90.13 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 89 (a)
(Mus musculus)
Mammalia Tpd52l2 33 16 34
  • 88.64 (n)
(Rattus norvegicus)
Mammalia Tpd52l2 33
  • 88.03 (n)
(Bos Taurus)
Mammalia TPD52L2 33 34
  • 87.46 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 63 (a)
(Gallus gallus)
Aves TPD52L2 33 34
  • 76.59 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 75 (a)
-- 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tpd52l2 33
  • 71.81 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2391 33
(Danio rerio)
Actinopterygii tpd52l2b 33 34
  • 69.36 (n)
tpd52l2a 34
  • 57 (a)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2893 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004868 33
  • 48.66 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5174 34
  • 18 (a)
(Caenorhabditis elegans)
Secernentea F13E6.1 34
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9626 34
  • 35 (a)
Species where no ortholog for TPD52L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPD52L2 Gene

Gene Tree for TPD52L2 (if available)
Gene Tree for TPD52L2 (if available)

Paralogs for TPD52L2 Gene

Paralogs for TPD52L2 Gene

(4) SIMAP similar genes for TPD52L2 Gene using alignment to 2 proteins: Pseudogenes for TPD52L2 Gene

genes like me logo Genes that share paralogs with TPD52L2: view

Variants for TPD52L2 Gene

Sequence variations from dbSNP and Humsavar for TPD52L2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000030152 -- 63,870,337(+) TGTGC(C/T)GCTGA intron-variant
rs1000065092 -- 63,887,418(+) CGGGG(G/T)CATTG intron-variant
rs1000315122 -- 63,867,030(+) CTTCC(C/G)GCAAC intron-variant
rs1000332900 -- 63,886,387(+) ACGGA(-/G)TCTTG intron-variant
rs1000514892 -- 63,886,801(+) CACCA(C/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPD52L2 Gene

Variant ID Type Subtype PubMed ID
nsv828804 CNV loss 20364138
nsv509784 CNV insertion 20534489
nsv469773 CNV gain 16826518
nsv428381 CNV gain+loss 18775914
esv2722986 CNV deletion 23290073
esv2722985 CNV deletion 23290073
esv2722983 CNV deletion 23290073
esv2722982 CNV deletion 23290073

Variation tolerance for TPD52L2 Gene

Residual Variation Intolerance Score: 37.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPD52L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPD52L2 Gene

Disorders for TPD52L2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TPD52L2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TPD52L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TPD52L2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPD52L2 Gene

Publications for TPD52L2 Gene

  1. Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system. (PMID: 9484778) Byrne JA … Gunning P (Oncogene 1998) 2 3 22 60
  2. Cloning of a third member of the D52 gene family indicates alternative coding sequence usage in D52-like transcripts. (PMID: 9838088) Nourse CR … Byrne JA (Biochimica et biophysica acta 1998) 3 4 22 60
  3. Nonredundant functions for tumor protein D52-like proteins support specific targeting of TPD52. (PMID: 18698023) Shehata M … Byrne JA (Clinical cancer research : an official journal of the American Association for Cancer Research 2008) 3 22 60
  4. A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins. (PMID: 16631610) Cao Q … Li J (Biochemical and biophysical research communications 2006) 3 22 60
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60

Products for TPD52L2 Gene

Sources for TPD52L2 Gene

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