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Aliases & Descriptions for TPD52L1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases D53 1 , 2 MGC8556 2 OTTHUMP00000017133 2 OTTHUMP00000017135 2 OTTHUMP00000017136 2 TPD52L2 2 hD53 1 , 2 , 3
Descriptions tumor protein D52-like 1 2 , 3 tumor protein D52-like 2 2 tumor protein D53 2
Search outside databases for aliases for TPD52L1 genePrevious GC identifers: GC06P125134 GC06P125322 GC06P125455
Summaries for TPD52L1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for TPD52L1 : This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains acoiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein isreported to be involved in cell proliferation and calcium signaling. It also interacts with themitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulatesMAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed,but the full-length nature of some variants has not yet been determined. [provided by RefSeq] Gene Wiki entry for TPD52L1
Genomic Location for TPD52L1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the TPD52L1 gene Entrez Gene cytogenetic band: 6q22-q23 Ensembl cytogenetic band: 6q22.31 HGNC cytogenetic band: 6q22-q23 TPD52L1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06P125516:
(about GC identifiers )
Start:
125,516,578 bp from pter
End:
125,627,252 bp from pter
Size:
110,675 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000006.10 NT_025741.14 Proteins for TPD52L1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
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Sigma-Aldrich ,
R&D Systems ,
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OriGene and/or,
Abcam ,
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Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
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Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: TPD53_HUMAN, Q16890 (See
protein sequence )Recommended Name: Tumor protein D53 Size : 204 amino acids; 22449 Da
Subunit : Forms homodimer or heterodimer with other members of the family
Secondary accessions : A8K757 A8K772 A8MUD2 A8MUJ7 A8MW70 O43397 Q5TC99 Q9BUQ6 Q9C054Alternative splicing : 4 isoforms : Q16890-1 Q16890-2 Q16890-3 Q16890-4
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (4 alternative transcripts):
NP_001003395.1 NP_001003396.1 NP_001003397.1 NP_003278.1 ENSEMBL proteins: ENSP00000357387 ENSP00000357379 ENSP00000306285 ENSP00000376275 ENSP00000376274 ENSP00000376273 ENSP00000357373 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for TPD52L1: Assays for TPD52L1:
Protein
Domains/ Families for TPD52L1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q16890 ProtoNet protein and cluster: Q16890
1 Blocks protein family : IPB007327 Tumor protein D52 UniProtKB/Swiss-Prot: TPD53_HUMAN, Q16890 Similarity : Belongs to the TPD52 family
Gene Function for TPD52L1
(According to MGI Jun 06 2009, UniProtKB ,
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_003287 Applied Biosystems Silencer ® siRNAs for TPD52L1 Sigma-Aldrich siRNA for TPD52L1 Sigma-Aldrich shRNA Panels and shRNA for TPD52L1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 4 ): NM_001003395                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 4 ): NM_001003395                                  untagged cDNA clones in CMV expression vector (see all 5 ): NM_001003395  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003287 Genatlas biochemistry entry for TPD52L1 :tumor protein D52-like 1,breast carcinoma associated (hD53) 2 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for TPD52L1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for TPD52L1 4 Interacting proteins for TPD52L1 (ENSP00000357387 3 Q16890 1 , 2 ) via UniProtKB, MINT, and/or STRING About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0000086 G2/M transition of mitotic cell cycle
IDA 16112108
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Transcripts for TPD52L1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
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ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_003287 Sigma-Aldrich siRNA for TPD52L1 Sigma-Aldrich shRNA Panels and shRNA for TPD52L1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001003395 NM_001003396 NM_001003397 NM_003287
REFSEQ mRNAs for TPD52L1 gene (4 alternative transcripts): NM_001003395.1 NM_001003396.1 NM_001003397.1 NM_003287.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001003395 NM_001003396 NM_001003397 NM_003287
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4 ): NM_001003395                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 4 ): NM_001003395                                  untagged cDNA clones in CMV expression vector (see all 5 ): NM_001003395  
Additional cDNA sequence: AF004427.1 AF208012.1 AK291866.1 AK291872.1 AK291887.1 BC002375.2 CR599743.1 U44427.1 U44428.1 U44429.1
23 DOTS entries : DT.100029626 DT.91750623 DT.100792704 DT.91750618 DT.443882 DT.100792694 DT.121377137 DT.121377141 DT.100029625 DT.91800395 DT.99932535 DT.99971140 DT.121377146 DT.75173596 DT.91750616 DT.91750625 DT.92024401 DT.102822250 DT.121377151 DT.40121989 DT.86843308 DT.95317525 DT.95317532
24/171 AceView cDNA sequences (see all 171
):BM977370 BM702144 AI912472 AW513729 AI620933 NM_003287 BQ772271 AA523855 U44427 CA420550 CB529260 CB160306 BM020481 AA723205 N66206 AI276300 AA948661 BQ002333 BE207625 BQ641312 AI492371 F36468 BU856836 AI215598
highest scoring ESTs for TPD52L1 :U44429 AA055661 AA055718 AA181574 AA523855 AA535805 AA576767 AA608564 AA632425 AA702528
Unigene Cluster for TPD52L1: Tumor protein D52-like 1 Hs.591347 [show with all ESTs ] Unigene Representative Sequence: U44429 GeneLoc Exon Structure 5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TPD52L1 (see all 11
) ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g SP1 :       -   -   -   -   -     -       -   -       -                 SP2 :       -   -   -   -   -     -       -   -   -     -                 SP3 :             -   -     -       -   -                       SP4 :                   -       -   -                       SP5 :       -   -   -   -   -     -       -   -   -   -   -                
About this scheme ECgene alternative splicing isoforms for TPD52L1 7 Ensembl transcripts including schematic representations : ENST00000368402
ENST00000368394
ENST00000304877
ENST00000392484
ENST00000392483
ENST00000392482
ENST00000368388
Expression for TPD52L1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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TPD52L1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for TPD52L1 1 / 2 / 3
5 probe-sets matching TPD52L1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: ACTGTCTCCASOURCE GeneReport for Unigene cluster: Hs.591347 Expression variation in blood from EXPOLDB for TPD52L1
Orthologs for TPD52L1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for TPD52L1 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for TPD52L1 ENSEMBL Gene Tree for TPD52L1 Paralogs for TPD52L1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for TPD52L1 gene TPD52L3 2 TPD52L2 2 TPD52 2
SNPs/Variants for TPD52L1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for TPD52L1 (up to first 250kb)
Disorders & Mutations for TPD52L1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
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OMIM: 604069 3 Novoseek disease relationships for TPD52L1 gene
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Medical News for TPD52L1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for TPD52L1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/20 PubMed articles for TPD52L1 gene (see all 20
): Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52). (PubMed id 8812487) 1, 2, 3, 4 Byrne J.A.... Basset P. (1996) D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells. (PubMed id 16112108) 1, 2, 3 Boutros R. and Byrne J.A. (2005) Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system. (PubMed id 9484778) 1, 3, 4 Byrne J.A.... Gunning P. (1998) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Identification and in situ hybridization mapping of a mouse Tpd52l1 (D53) orthologue to chromosome 10A4-B2. (PubMed id 9730602) 1, 3 Byrne J.A....Gunning P. (1998) Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins. (PubMed id 12963375) 1, 3 Boutros R....Byrne J.A. (2003) A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins. (PubMed id 16631610) 1, 3 Cao Q.... Li J. (2006) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 4 Dephoure N.... Gygi S.P. (2008) Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations. (PubMed id 16620967) 3 Barbaric D....Byrne J.A. (2006) A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070) 3 Stelzl U....Wanker E.E. (2005)
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Genome Databases showing TPD52L1
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ECgene ,
and/or
H-InvDB )
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Specialized Databases showing TPD52L1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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