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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TPD52L1 Gene

protein-coding   GIFtS: 63
GCID: GC06P125516

Tumor Protein D52-Like 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Protein D52-Like 11 2 3
hD532 3
D532
Tumor Protein D532

External Ids:    HGNC: 120061   Entrez Gene: 71642   Ensembl: ENSG000001119077   OMIM: 6040695   UniProtKB: Q168903   

Export aliases for TPD52L1 gene to outside databases

Previous GC identifers: GC06P125134 GC06P125322 GC06P125455 GC06P123051


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TPD52L1 Gene:
This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a coiled-coil
domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in
cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase
kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced
transcript variants have been observed, but the full-length nature of some variants has not yet been determined.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TPD52L1 Gene: 
TPD52L1 (tumor protein D52-like 1) is a protein-coding gene. Diseases associated with TPD52L1 include collecting duct carcinoma, and childhood leukemia, and among its related super-pathways are Golgi Associated Vesicle Biogenesis and Translocation of GLUT4 to the Plasma Membrane. GO annotations related to this gene include protein homodimerization activity and identical protein binding. An important paralog of this gene is TPD52L3.

Gene Wiki entry for TPD52L1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TPD52L1 gene promoter:
         TBP   RFX1   E2F-1   E2F   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): TPD52L1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TPD52L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPD52L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22-q23   Ensembl cytogenetic band:  6q22.31   HGNC cytogenetic band: 6q22-q23

TPD52L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPD52L1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P125516:  view genomic region     (about GC identifiers)

Start:
125,440,195 bp from pter      End:
125,585,553 bp from pter
Size:
145,359 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TPD53_HUMAN, Q16890 (See protein sequence)
Recommended Name: Tumor protein D53  
Size: 204 amino acids; 22449 Da
Subunit: Forms a homodimer or heterodimer with other members of the family
Sequence caution: Sequence=AAC98475.1; Type=Erroneous initiation;
Secondary accessions: A8K757 A8K772 A8MUD2 A8MUJ7 A8MW70 O43397 Q5TC99 Q5TDQ0 Q9BUQ6 Q9C054
Alternative splicing: 4 isoforms:  Q16890-1   Q16890-2   Q16890-3   Q16890-4   

Explore the universe of human proteins at neXtProt for TPD52L1: NX_Q16890

Explore proteomics data for TPD52L1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16890

  • TPD52L1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TPD52L1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001003395.1  NP_001003396.1  NP_001003397.1  NP_003278.1  

    ENSEMBL proteins: 
     ENSP00000432806   ENSP00000306285   ENSP00000434142   ENSP00000357387   ENSP00000357373  
     ENSP00000436953   ENSP00000434743   ENSP00000435447   ENSP00000432590   ENSP00000376273  
     ENSP00000432787  
    Reactome Protein details: Q16890
    Human Recombinant Protein Products for TPD52L1: 
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    ProSpec Recombinant Protein for TPD52L1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA12963375
    GO:0048471perinuclear region of cytoplasm IDA12963375

    TPD52L1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007327 TPD52

    Graphical View of Domain Structure for InterPro Entry Q16890

    ProtoNet protein and cluster: Q16890

    1 Blocks protein domain: IPB007327 Tumor protein D52

    UniProtKB/Swiss-Prot: TPD53_HUMAN, Q16890
    Similarity: Belongs to the TPD52 family


    TPD52L1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for TPD52L1:
    tumor protein D52-like 1,breast carcinoma associated (hD53)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12963375
    GO:0008656cysteine-type endopeptidase activator activity involved in apoptotic process IDA14761963
    GO:0042802identical protein binding IPI9484778
    GO:0042803protein homodimerization activity IDA9484778
    GO:0046982protein heterodimerization activity IDA9484778
         
    TPD52L1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TPD52L1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TPD52L1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    2Membrane Trafficking
    Membrane Trafficking0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4        Reactome Pathways for TPD52L1
        Membrane Trafficking
    Clathrin derived vesicle budding
    Golgi Associated Vesicle Biogenesis
    trans-Golgi Network Vesicle Budding



    TPD52L1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TPD52L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/24 Interacting proteins for TPD52L1 (Q168901, 2, 3 ENSP000003573874) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TPD52P553271, 3, ENSP000003683914EBI-717470,EBI-782581 I2D: score=4 STRING: ENSP00000368391
    SFNP319472, 3, ENSP000003409894MINT-8009280 I2D: score=1 STRING: ENSP00000340989
    EIF3JO758222, 3MINT-63144 I2D: score=5 
    GPR135Q8IZ082, 3MINT-63146 I2D: score=5 
    YAE1D1Q9NRH12, 3MINT-63147 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle IDA16112108
    GO:0006309apoptotic DNA fragmentation IDA14761963
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IDA14761963
    GO:0043406positive regulation of MAP kinase activity IDA14761963
    GO:0046330positive regulation of JNK cascade IDA14761963

    TPD52L1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TPD52L1 (TPD53)

    Search CenterWatch for drugs/clinical trials and news about TPD52L1 / TPD53

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TPD52L1 gene (4 alternative transcripts): 
    NM_001003395.1  NM_001003396.1  NM_001003397.1  NM_003287.2  

    Unigene Cluster for TPD52L1:

    Tumor protein D52-like 1
    Hs.591347  [show with all ESTs]
    Unigene Representative Sequence: U44429
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534368 ENST00000304877 ENST00000534000(uc003pzu.1 uc003pzv.1 uc003pzw.1 uc003pzy.1)
    ENST00000368402 ENST00000368388 ENST00000527711 ENST00000392483 ENST00000528193
    ENST00000532978(uc003pzx.1) ENST00000532429 ENST00000534199 ENST00000392482(uc003pzz.1)
    ENST00000524679 ENST00000532423 ENST00000530868 ENST00000576089 ENST00000571678

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    Additional mRNA sequence: 

    AF004427.1 AF208012.1 AK291866.1 AK291872.1 AK291887.1 BC002375.2 U44427.1 U44428.1 
    U44429.1 

    20 DOTS entries:

    DT.100029626  DT.91750623  DT.100792704  DT.91750618  DT.100792694  DT.443882  DT.121377137  DT.121377141 
    DT.100029625  DT.91800395  DT.121377146  DT.75173596  DT.91750616  DT.91750625  DT.92024401  DT.99971140 
    DT.102822250  DT.121377151  DT.95317525  DT.95317532 

    24/171 AceView cDNA sequences (see all 171):

    CR599743 CB529260 AA723205 AW513729 AI370762 BM020481 BQ772271 AI620933 
    AF004427 AI701952 BE407159 AA745950 NM_001003395 BE207625 AI185226 BI091199 
    AI492371 NM_003287 AA948661 CA420550 BM702144 AA523855 BM913790 NM_001003396 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TPD52L1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
    SP1:                    -     -     -     -     -           -                 -     -                 -                                             
    SP2:                    -     -     -     -     -           -                 -     -     -           -                                             
    SP3:                                      -     -           -                 -     -                                                               
    SP4:                                                        -                 -     -                                                               
    SP5:                    -     -     -     -     -           -                 -     -     -     -     -                                             


    ECgene alternative splicing isoforms for TPD52L1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TPD52L1 expression in normal human tissues (normalized intensities)      TPD52L1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTCTCCA
    TPD52L1 Expression
    About this image


    TPD52L1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Adult Endothelial Cells Blood Brain Barrier
             Thalamus
             Septum   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Normal Human Articular chondrocytes (NHAC)   
             skeleton/cranium/chondrocranium   
     
     Blood Brain Barrier (Nervous System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Human Iris Pigment Epithelial Cells (HIPEpiC)   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier

    See TPD52L1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TPD52L1

    SOURCE GeneReport for Unigene cluster: Hs.591347
        SABiosciences Expression via Pathway-Focused PCR Array including TPD52L1: 
              Apoptosis 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPD52L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TPD52L1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tpd52l11 , 5 tumor protein D52-like 11, 5 88.4(n)1
    90.69(a)1
      10 (17.36 cM)5
    219871  NM_009413.11  NP_033439.11 
     313323805 
    chicken
    (Gallus gallus)
    Aves TPD52L11 tumor protein D52-like 1 78.43(n)
    83.82(a)
      374049  NM_204215.1  NP_989546.1 
    lizard
    (Anolis carolinensis)
    Reptilia TPD52L16
    tumor protein D52-like 1
    76(a)
    1 ↔ 1
    1(180754865-180807908)
    zebrafish
    (Danio rerio)
    Actinopterygii BQ093893.12   -- 76.48(n)    BQ093893.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51746
    --
    13(a)
    1 → many
    2R(14308915-14313732)
    worm
    (Caenorhabditis elegans)
    Secernentea F13E6.16
    Uncharacterized protein F13E6.1
    27(a)
    1 → many
    X(10675699-10677111)


    ENSEMBL Gene Tree for TPD52L1 (if available)
    TreeFam Gene Tree for TPD52L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TPD52L1 gene
    TPD52L32  TPD52L22  TPD522  
    6 SIMAP similar genes for TPD52L1 using alignment to 6 protein entries:     TPD53_HUMAN (see all proteins):
    hD53    TPD52    PrLZ    DKFZp686A1765    TPD52L3    TPD52L2

    TPD52L1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2395 SNPs in TPD52L1 are shown (see all 2395)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs575142401,2
    C--123053452(+) CTAAG-/AAAG  
            
    GGCCT
    4 -- int10--------
    rs721225491,2
    C--123055569(+) TTCTC-/AAGGCC 4 -- int11Minor allele frequency- A:0.00CSA 2
    rs592588951,2
    F--123058723(+) GCAAAT/ATCTCC 4 -- int11Minor allele frequency- A:0.06NA 120
    rs1995840761,2
    --123076573(+) CAAAA-/CAAAAC
            
    AAAAT
    4 -- int10--------
    rs38395511,2
    C--123078196(-) AAAAA-/AGAATC 4 -- int11Minor allele frequency- A:0.50CSA 2
    rs2017592321,2
    --123078490(+) TATAT-/ACATACA 4 -- int10--------
    rs38421201,2
    C--123078851(-) AATAC-/TCAC  
            
    AATCA
    4 -- int10--------
    rs670177461,2
    C--123078853(+) GATTG-/GT/GT 
     GA
    /TGAT
    TATTC
    4 -- int10--------
    rs1429952151,2
    C--123081660(+) ATAAG-/AAAGAG 4 -- int10--------
    rs30407261,2
    C--123091951(-) AAAAA-/A/A   
       A
    /AAA
    CTATT
    8 -- int1 cds1 trp31NA 2

    HapMap Linkage Disequilibrium report for TPD52L1 (125440195 - 125585553 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for TPD52L1 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2732675CNV Deletion23290073
    esv2732678CNV Deletion23290073
    esv2732677CNV Deletion23290073
    esv2732676CNV Deletion23290073
    esv2677911CNV Deletion23128226
    nsv830795CNV Loss17160897
    nsv886626CNV Gain21882294
    nsv886629CNV Gain21882294
    nsv886625CNV Gain21882294
    dgv6989n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604069    OMIM disorders: --

    4 diseases for TPD52L1:    About MalaCards
    collecting duct carcinoma    childhood leukemia    breast cancer    leukemia


    TPD52L1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for TPD52L1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast carcinoma 64.6 10 12963375 (2), 9838088 (1), 16112108 (1), 9484778 (1) (see all 6)
    tumors 22.3 9 15489060 (1), 16112108 (1), 8812487 (1), 9730602 (1)
    breast cancer 21 6 16112108 (3), 18698023 (1)

    Genetic Association Database (GAD): TPD52L1

    Export disorders for TPD52L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TPD52L1 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with TPD52L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52). (PubMed id 8812487)1, 2, 3, 9 Byrne J.A.... Basset P. (1996)
    2. D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells. (PubMed id 16112108)1, 3, 9 Boutros R. and Byrne J.A. (2005)
    3. Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system. (PubMed id 9484778)1, 2, 9 Byrne J.A.... Gunning P. (1998)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Identification and in situ hybridization mapping of a mouse Tpd52l1 (D53) orthologue to chromosome 10A4-B2. (PubMed id 9730602)1, 9 Byrne J.A....Gunning P. (1998)
    6. Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins. (PubMed id 12963375)1, 9 Boutros R....Byrne J.A. (2003)
    7. A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins. (PubMed id 16631610)1, 9 Cao Q.... Li J. (2006)
    8. 14-3-3 proteins sequester a pool of soluble TRIM32 ubi quitin ligase to repress autoubiquitylation and cytoplasmic body formation. (PubMed id 23444366)1 Ichimura T....Hachiya N. (2013)
    9. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7164 HGNC: 12006 AceView: TPD52L1 Ensembl:ENSG00000111907 euGenes: HUgn7164
    ECgene: TPD52L1 H-InvDB: TPD52L1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TPD52L1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TPD52L1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TPD52L1 gene:
    Search GeneIP for patents involving TPD52L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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