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TPD52L1 Gene

protein-coding   GIFtS: 63
GCID: GC06P125516

Tumor Protein D52-Like 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Protein D52-Like 11 2 3
hD532 3
D532 5
Tumor Protein D532

External Ids:    HGNC: 120061   Entrez Gene: 71642   Ensembl: ENSG000001119077   OMIM: 6040695   UniProtKB: Q168903   

Export aliases for TPD52L1 gene to outside databases

Previous GC identifers: GC06P125134 GC06P125322 GC06P125455 GC06P123051


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TPD52L1 Gene:
This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a coiled-coil
domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in
cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase
kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced
transcript variants have been observed, but the full-length nature of some variants has not yet been determined.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TPD52L1 Gene:
TPD52L1 (tumor protein D52-like 1) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity and protein homodimerization activity. An important paralog of this gene is TPD52L3.

Gene Wiki entry for TPD52L1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TPD52L1 gene promoter:
         TBP   RFX1   E2F-1   E2F   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): TPD52L1 promoter sequence
   Search Chromatin IP Primers for TPD52L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPD52L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22-q23   Ensembl cytogenetic band:  6q22.31   HGNC cytogenetic band: 6q22-q23

TPD52L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPD52L1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P125516:  view genomic region     (about GC identifiers)

Start:
125,440,195 bp from pter      End:
125,585,553 bp from pter
Size:
145,359 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TPD53_HUMAN, Q16890 (See protein sequence)
Recommended Name: Tumor protein D53  
Size: 204 amino acids; 22449 Da
Subunit: Forms a homodimer or heterodimer with other members of the family
Sequence caution: Sequence=AAC98475.1; Type=Erroneous initiation;
Secondary accessions: A8K757 A8K772 A8MUD2 A8MUJ7 A8MW70 O43397 Q5TC99 Q5TDQ0 Q9BUQ6 Q9C054
Alternative splicing: 4 isoforms:  Q16890-1   Q16890-2   Q16890-3   Q16890-4   

Explore the universe of human proteins at neXtProt for TPD52L1: NX_Q16890

Explore proteomics data for TPD52L1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TPD52L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001003395.1  NP_001003396.1  NP_001003397.1  NP_003278.1  

    ENSEMBL proteins: 
     ENSP00000432806   ENSP00000306285   ENSP00000434142   ENSP00000357387   ENSP00000357373  
     ENSP00000436953   ENSP00000434743   ENSP00000435447   ENSP00000432590   ENSP00000376273  
     ENSP00000432787  
    Reactome Protein details: Q16890

    TPD52L1 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for TPD52L1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007327 TPD52

    Graphical View of Domain Structure for InterPro Entry Q16890

    ProtoNet protein and cluster: Q16890

    1 Blocks protein domain: IPB007327 Tumor protein D52

    UniProtKB/Swiss-Prot: TPD53_HUMAN, Q16890
    Similarity: Belongs to the TPD52 family


    Find genes that share domains with TPD52L1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for TPD52L1:
    tumor protein D52-like 1,breast carcinoma associated (hD53)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12963375
    GO:0008656cysteine-type endopeptidase activator activity involved in apoptotic process ----
    GO:0042802identical protein binding IPI9484778
    GO:0042803protein homodimerization activity IDA9484778
    GO:0046982protein heterodimerization activity IDA9484778
         
    Find genes that share ontologies with TPD52L1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TPD52L1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TPD52L1
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    miRNA
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    hsa-mir-335-5p (MIRT018898)

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    hsa-miR-513b hsa-miR-302f
    SwitchGear 3'UTR luciferase reporter plasmidTPD52L1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): TPD52L1 (NM_001003396)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPD52L1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA12963375
    GO:0048471perinuclear region of cytoplasm IDA12963375

    Find genes that share ontologies with TPD52L1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TPD52L1 About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    Membrane Trafficking0.32


    Find genes that share SuperPaths with TPD52L1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for TPD52L1
        Golgi Associated Vesicle Biogenesis


        Pathway & Disease-focused RT2 Profiler PCR Array including TPD52L1: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TPD52L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for TPD52L1 (Q168901, 2, 3 ENSP000003573874) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TPD52P553271, 3, ENSP000003683914EBI-717470,EBI-782581 I2D: score=4 STRING: ENSP00000368391
    SFNP319472, 3, ENSP000003409894MINT-8009280 I2D: score=1 STRING: ENSP00000340989
    EIF3JO758222, 3MINT-63144 I2D: score=5 
    GPR135Q8IZ082, 3MINT-63146 I2D: score=5 
    YAE1D1Q9NRH12, 3MINT-63147 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle IDA16112108
    GO:0006309apoptotic DNA fragmentation ----
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process ----
    GO:0043281regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA14761963
    GO:0043406positive regulation of MAP kinase activity IDA14761963

    Find genes that share ontologies with TPD52L1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TPD52L1 (TPD53)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TPD52L1 gene (4 alternative transcripts): 
    NM_001003395.1  NM_001003396.1  NM_001003397.1  NM_003287.2  

    Unigene Cluster for TPD52L1:

    Tumor protein D52-like 1
    Hs.591347  [show with all ESTs]
    Unigene Representative Sequence: U44429
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534368 ENST00000304877 ENST00000534000(uc003pzu.1 uc003pzv.1 uc003pzw.1 uc003pzy.1)
    ENST00000368402 ENST00000368388 ENST00000527711 ENST00000392483 ENST00000528193
    ENST00000532978(uc003pzx.1) ENST00000532429 ENST00000534199 ENST00000392482(uc003pzz.1)
    ENST00000524679 ENST00000532423 ENST00000530868 ENST00000576089 ENST00000571678

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate TPD52L1:
    hsa-miR-513b hsa-miR-302f
    SwitchGear 3'UTR luciferase reporter plasmidTPD52L1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): TPD52L1 (NM_001003396)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TPD52L1
      QuantiTect SYBR Green Assays in human, mouse, rat TPD52L1
      QuantiFast Probe-based Assays in human, mouse, rat TPD52L1

    Additional mRNA sequence: 

    AF004427.1 AF208012.1 AK291866.1 AK291872.1 AK291887.1 BC002375.2 U44427.1 U44428.1 
    U44429.1 

    20 DOTS entries:

    DT.100029626  DT.91750623  DT.100792704  DT.91750618  DT.100792694  DT.443882  DT.121377137  DT.121377141 
    DT.100029625  DT.91800395  DT.121377146  DT.75173596  DT.91750616  DT.91750625  DT.92024401  DT.99971140 
    DT.102822250  DT.121377151  DT.95317525  DT.95317532 

    Selected AceView cDNA sequences (see all 171):

    F32726 CA432078 AW513729 AW118159 AI185226 BQ772271 AI701952 BU538830 
    AL120549 AI659778 BM702144 AF004427 AA523855 BM977370 BM702179 AI276300 
    AA948661 NM_001003396 AF208012 CB529260 CA420550 AA723205 BQ641312 W69680 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TPD52L1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
    SP1:                    -     -     -     -     -           -                 -     -                 -                                             
    SP2:                    -     -     -     -     -           -                 -     -     -           -                                             
    SP3:                                      -     -           -                 -     -                                                               
    SP4:                                                        -                 -     -                                                               
    SP5:                    -     -     -     -     -           -                 -     -     -     -     -                                             


    ECgene alternative splicing isoforms for TPD52L1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TPD52L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTCTCCA
    TPD52L1 Expression
    About this image


    TPD52L1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebellum
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Neural Tube (Nervous System)
             Diencephalic Roof Plate
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Ovary (Reproductive System)
             Oviduct
    TPD52L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TPD52L1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591347
        Pathway & Disease-focused RT2 Profiler PCR Array including TPD52L1: 
              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPD52L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TPD52L1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tpd52l11 , 5 tumor protein D52-like 11, 5 88.4(n)1
    90.69(a)1
      10 (17.36 cM)5
    219871  NM_009413.11  NP_033439.11 
     313323805 
    chicken
    (Gallus gallus)
    Aves TPD52L11 tumor protein D52-like 1 78.43(n)
    83.82(a)
      374049  NM_204215.1  NP_989546.1 
    lizard
    (Anolis carolinensis)
    Reptilia TPD52L16
    tumor protein D52-like 1
    76(a)
    1 ↔ 1
    1(180754865-180807908)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tpd52l11 tumor protein D52-like 1 66.34(n)
    72.41(a)
      100487402  XM_002936010.2  XP_002936056.2 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ093893.12   -- 76.48(n)    BQ093893.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51746
    --
    15(a)
    1 → many
    2R(14308915-14313732)
    worm
    (Caenorhabditis elegans)
    Secernentea F13E6.16
    Protein F13E6.1 (F13E6.1) mRNA, complete cds
    26(a)
    1 → many
    X(10675699-10677109) WBGene00008745


    ENSEMBL Gene Tree for TPD52L1 (if available)
    TreeFam Gene Tree for TPD52L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TPD52L1 gene
    TPD52L32  TPD52L22  TPD522  
    5 SIMAP similar genes for TPD52L1 using alignment to 6 protein entries:     TPD53_HUMAN (see all proteins):
    hD53    TPD52    DKFZp686A1765    TPD52L3    TPD52L2

    Find genes that share paralogs with TPD52L1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TPD52L1 (see all 2395)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs575142401,2
    C--123053452(+) CTAAG-/AAAG  
            
    GGCCT
    4 -- int10--------
    rs721225491,2
    C--123055569(+) TTCTC-/AAGGCC 4 -- int11Minor allele frequency- A:0.00CSA 2
    rs592588951,2
    F--123058723(+) GCAAAT/ATCTCC 4 -- int11Minor allele frequency- A:0.06NA 120
    rs1995840761,2
    --123076573(+) CAAAA-/CAAAAC
            
    AAAAT
    4 -- int10--------
    rs38395511,2
    C--123078196(-) AAAAA-/AGAATC 4 -- int11Minor allele frequency- A:0.50CSA 2
    rs2017592321,2
    --123078490(+) TATAT-/ACATACA 4 -- int10--------
    rs38421201,2
    C--123078851(-) AATAC-/TCAC  
            
    AATCA
    4 -- int10--------
    rs670177461,2
    C--123078853(+) GATTG-/GT/GT 
     GA
    /TGAT
    TATTC
    4 -- int10--------
    rs1429952151,2
    C--123081660(+) ATAAG-/AAAGAG 4 -- int10--------
    rs30407261,2
    C--123091951(-) AAAAA-/A/A   
       A
    /AAA
    CTATT
    8 -- int1 cds1 trp31NA 2

    HapMap Linkage Disequilibrium report for TPD52L1 (125440195 - 125585553 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TPD52L1 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732675CNV Deletion23290073
    esv2732678CNV Deletion23290073
    esv2732677CNV Deletion23290073
    esv2732676CNV Deletion23290073
    esv2677911CNV Deletion23128226
    nsv830795CNV Loss17160897
    nsv886626CNV Gain21882294
    nsv886629CNV Gain21882294
    nsv886625CNV Gain21882294
    dgv6989n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604069    OMIM disorders: --


    Find genes that share disorders with TPD52L1           About GenesLikeMe

    3 Novoseek inferred disease relationships for TPD52L1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast carcinoma 64.6 10 12963375 (2), 9838088 (1), 16112108 (1), 9484778 (1) (see all 6)
    tumors 22.3 9 15489060 (1), 16112108 (1), 8812487 (1), 9730602 (1)
    breast cancer 21 6 16112108 (3), 18698023 (1)

    Genetic Association Database (GAD): TPD52L1

    Export disorders for TPD52L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TPD52L1 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with TPD52L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52). (PubMed id 8812487)1, 2, 3, 9 Byrne J.A.... Basset P. (Genomics 1996)
    2. D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells. (PubMed id 16112108)1, 3, 9 Boutros R. and Byrne J.A. (Exp. Cell Res. 2005)
    3. Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system. (PubMed id 9484778)1, 2, 9 Byrne J.A.... Gunning P. (Oncogene 1998)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Identification and in situ hybridization mapping of a mouse Tpd52l1 (D53) orthologue to chromosome 10A4-B2. (PubMed id 9730602)1, 9 Byrne J.A....Gunning P. (Cytogenet. Cell Genet. 1998)
    6. Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins. (PubMed id 12963375)1, 9 Boutros R....Byrne J.A. (J. Mol. Biol. 2003)
    7. A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins. (PubMed id 16631610)1, 9 Cao Q.... Li J. (Biochem. Biophys. Res. Commun. 2006)
    8. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    9. 14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation. (PubMed id 23444366)1 Ichimura T....Hachiya N. (J. Cell. Sci. 2013)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7164 HGNC: 12006 AceView: TPD52L1 Ensembl:ENSG00000111907 euGenes: HUgn7164
    ECgene: TPD52L1 H-InvDB: TPD52L1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TPD52L1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TPD52L1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TPD52L1 gene:
    Search GeneIP for patents involving TPD52L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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