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TPD52L1 Gene

protein-coding   GIFtS: 59

GC06P125516
tumor protein D52-like 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
D53 1, 2
MGC8556 2
OTTHUMP00000017133 2
OTTHUMP00000017135 2
OTTHUMP00000017136 2
TPD52L2 2
hD53 1, 2, 3
Descriptions
tumor protein D52-like 1 2, 3
tumor protein D52-like 2 2
tumor protein D53 2
External Ids
HGNC: 120061
Entrez Gene: 71642
UniProtKB: Q168903
Ensembl: ENSG000001119077
Search outside databases for aliases for TPD52L1 gene

Previous GC identifers: GC06P125134 GC06P125322 GC06P125455

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TPD52L1:
This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a
coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is
reported to be involved in cell proliferation and calcium signaling. It also interacts with the
mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates
MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed,
but the full-length nature of some variants has not yet been determined. [provided by RefSeq]

Gene Wiki entry for TPD52L1
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TPD52L1 gene  

Entrez Gene cytogenetic band: 6q22-q23   Ensembl cytogenetic band:  6q22.31   HGNC cytogenetic band: 6q22-q23

TPD52L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P125516:     (about GC identifiers)

Start:
125,516,578 bp from pter
End:
125,627,252 bp from pter
Size:
110,675 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000006.10  NT_025741.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TPD53_HUMAN, Q16890 (See protein sequence)
Recommended Name: Tumor protein D53  
Size: 204 amino acids; 22449 Da
Subunit: Forms homodimer or heterodimer with other members of the family
Secondary accessions: A8K757 A8K772 A8MUD2 A8MUJ7 A8MW70 O43397 Q5TC99 Q9BUQ6 Q9C054
Alternative splicing: 4 isoforms:  Q16890-1   Q16890-2   Q16890-3   Q16890-4   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (4 alternative transcripts): 
    NP_001003395.1  NP_001003396.1  NP_001003397.1  NP_003278.1  


    ENSEMBL proteins: 
    ENSP00000357387 ENSP00000357379 ENSP00000306285 ENSP00000376275 ENSP00000376274 ENSP00000376273 
    ENSP00000357373 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (TPD52L1)
    Human Recombinant Proteins from Abnova (TPD52L1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IDA12963375 16112108
    GO:0048471 perinuclear region of cytoplasm IDA12963375 16112108
    About this table

    Antibodies for TPD52L1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (TPD52L1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (TPD52L1)
    Novus Biologicals Antibodies for TPD52L1

    Assays for TPD52L1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR007327 TPD52


       GeneDecks  TPD52L1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q16890

    ProtoNet protein and cluster: Q16890

    1 Blocks protein family: IPB007327 Tumor protein D52

    UniProtKB/Swiss-Prot: TPD53_HUMAN, Q16890
    Similarity: Belongs to the TPD52 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TPD52L1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_003287

                  Applied Biosystems Silencer® siRNAs for TPD52L1

                  Sigma-Aldrich siRNA for TPD52L1  
                         Sigma-Aldrich shRNA Panels and shRNA for TPD52L1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for TPD52L1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001003395
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001003395
                                     untagged cDNA clones in CMV expression vector (see all 5): NM_001003395 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_003287

    Genatlas biochemistry entry for TPD52L1:
    tumor protein D52-like 1,breast carcinoma associated (hD53)

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042803 protein homodimerization activity IDA9484778
    GO:0046982 protein heterodimerization activity IDA9484778
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  TPD52L1 


    4 Interacting proteins for TPD52L1 (ENSP000003573873 Q168901, 2) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TPD52P553271STRING (score=.878) EBI-717470, EBI-782581
    TPD52L1Q168901EBI-717470, EBI-717470
    YWHABP319462MINT-15934 MINT-15935 MINT-15933
    YWHAZP631042MINT-17367 MINT-17368 MINT-17366
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086 G2/M transition of mitotic cell cycle IDA16112108
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for TPD52L1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TPD52L1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_003287

                  Sigma-Aldrich siRNA for TPD52L1  
                         Sigma-Aldrich shRNA Panels and shRNA for TPD52L1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001003395  NM_001003396  NM_001003397  NM_003287  

    REFSEQ mRNAs for TPD52L1 gene (4 alternative transcripts): 

    NM_001003395.1   NM_001003396.1   NM_001003397.1   NM_003287.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001003395  NM_001003396  NM_001003397  NM_003287  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001003395
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001003395
                                     untagged cDNA clones in CMV expression vector (see all 5): NM_001003395 

    Additional cDNA sequence: 

    AF004427.1 AF208012.1 AK291866.1 AK291872.1 AK291887.1 BC002375.2 CR599743.1 U44427.1 
    U44428.1 U44429.1 

    23 DOTS entries:

    DT.100029626  DT.91750623  DT.100792704  DT.91750618  DT.443882  DT.100792694  DT.121377137  DT.121377141 
    DT.100029625  DT.91800395  DT.99932535  DT.99971140  DT.121377146  DT.75173596  DT.91750616  DT.91750625 
    DT.92024401  DT.102822250  DT.121377151  DT.40121989  DT.86843308  DT.95317525  DT.95317532 

    24/171 AceView cDNA sequences (see all 171 ):

    BM977370 BM702144 AI912472 AW513729 AI620933 NM_003287 BQ772271 AA523855 
    U44427 CA420550 CB529260 CB160306 BM020481 AA723205 N66206 AI276300 
    AA948661 BQ002333 BE207625 BQ641312 AI492371 F36468 BU856836 AI215598 

    highest scoring ESTs for TPD52L1:

    U44429 AA055661 AA055718 AA181574 AA523855 AA535805 AA576767 AA608564 AA632425 AA702528 

    Unigene Cluster for TPD52L1:

    Tumor protein D52-like 1
    Hs.591347  [show with all ESTs]
    Unigene Representative Sequence: U44429


    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TPD52L1 (see all 11 )

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
    SP1:                    -     -     -     -     -           -                 -     -                 -                                             
    SP2:                    -     -     -     -     -           -                 -     -     -           -                                             
    SP3:                                      -     -           -                 -     -                                                               
    SP4:                                                        -                 -     -                                                               
    SP5:                    -     -     -     -     -           -                 -     -     -     -     -                                             

    About this scheme

    ECgene alternative splicing isoforms for TPD52L1

    7 Ensembl transcripts including schematic representations:
    ENST00000368402  ENST00000368394  ENST00000304877  ENST00000392484  ENST00000392483  ENST00000392482  
    ENST00000368388  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    TPD52L1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for TPD52L1

    1 / 2 / 3

    5 probe-sets matching TPD52L1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    32136_r_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 U44429 1.00 1.00 1.00 1

    210372_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF208012 0.80 1.00 0.91 1

    203786_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_003287 0.60 1.00 0.82 1

    210372_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    203786_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: ACTGTCTCCA

    SOURCE GeneReport for Unigene cluster: Hs.591347

    Expression variation in blood from EXPOLDB for TPD52L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for TPD52L1 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TPD52L11   -- tumor protein D52-like 1 90.86(n)
    93.91(a)
    612660  XM_850392.1  XP_855485.1 
    chimpanzee
    (Pan troglodytes)
    TPD52L11   -- tumor protein D52-like 1 99.35(n)
    99.51(a)
    462980  XM_518724.2  XP_518724.2 
    cow
    (Bos taurus)
    TPD52L11   -- tumor protein D52-like 1 89.87(n)
    91.67(a)
    534629  NM_001076033.1  NP_001069501.1 
    rat
    (Rattus norvegicus)
    Tpd52l11   -- tumor protein D52-like 1 86.93(n)
    89.71(a)
    689256  XM_001070150.1  XP_001070150.1 
    mouse
    (Mus musculus)
    Tpd52l11, 5 105
    tumor protein D52-like 11, 5 88.4(n)1
    90.69(a)1
    219871  NM_009413.11  NP_033439.11 
     AF0044285  AI4644815  (see all 14)
    About this table        Species with no ortholog for TPD52L1

    ENSEMBL Gene Tree for TPD52L1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for TPD52L1 gene
    TPD52L32  TPD52L22  TPD522  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/767 NCBI SNPs in TPD52L1 are shown (see all 767 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 257)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs5557611,2
    A,C,F,H,O125517214(+) CCCAGG/CGCCGT 4 -- int1 ut516Minor allele frequency- C:0.40MN EA EU WA 1716
    rs11604951,2
    A,C,F,H,O125626802(+) AAAATA/CATCTC 4 -- ng3112Minor allele frequency- C:0.32MN EU EA WA NA 1162
    rs5573391,2
    A,C,F,O125517344(+) TGAACT/GTTACC 4 -- int1 ut516Minor allele frequency- G:0.34EA MN NA 1858
    rs5432831,2
    A,C,F125517257(-) GATCCT/CCTCAC 4 -- int1 ut511Minor allele frequency- C:0.48MN 184
    rs4850761,2
    C,F,H125516180(-) ggctgG/Caatag 4 -- ng5113Minor allele frequency- C:0.42NS EU EA WA 934
    --
    rs69052311,2
    C,F,H125592012(+) AGAAAG/AGCATC 4 K/R mis1 ese3 trp38Minor allele frequency- A:0.01EU EA WA 840
    rs22771111,2
    C,F,O125516838(-) ACTCTC/TGGGGC 4 -- int1 ng511Minor allele frequency- T:0.31EA 1496
    --
    rs5182141,2
    A,C125514850(-) TGAGGG/TCTTTG 3 -- ng51 tfbs30--------
    --
    rs18792731,2
    A,C125516345(-) tagcaC/Tgatgt 4 -- ng51 tfbs30--------
    --
    rs11604941,2
    C,F125626687(+) GAGTGA/GGACAC 4 -- ng31 ese35Minor allele frequency- C:0.01EA NA MN 350
    About this table

    HapMap Linkage Disequilibrium images for TPD52L1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 604069

    3 Novoseek disease relationships for TPD52L1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast carcinoma 65.21 10 12963375 (2), 9838088 (1), 16112108 (1), 9484778 (1) (see all 6)
    tumors 23.38 9 15489060 (1), 16112108 (1), 8812487 (1), 9730602 (1)
    breast cancer 22.29 6 16112108 (3), 18698023 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/20 PubMed articles for TPD52L1 gene (see all 20 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 7164 HGNC: 12006 AceView: TPD52L1 Ensembl:ENSG00000111907 euGenes: HUgn7164
    ECgene: TPD52L1 H-InvDB: TPD52L1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for TPD52L1 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for TPD52L1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for TPD52L1 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
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