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Aliases for TPD52L1 Gene

Aliases for TPD52L1 Gene

  • Tumor Protein D52-Like 1 2 3 4 5
  • Tumor Protein D53 3
  • HD53 4
  • D53 3

External Ids for TPD52L1 Gene

Previous GeneCards Identifiers for TPD52L1 Gene

  • GC06P125322
  • GC06P125455
  • GC06P125516
  • GC06P123051

Summaries for TPD52L1 Gene

Entrez Gene Summary for TPD52L1 Gene

  • This gene encodes a member of a family of proteins that contain coiled-coil domains and may form hetero- or homomers. The encoded protein is involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed. [provided by RefSeq, Jan 2016]

GeneCards Summary for TPD52L1 Gene

TPD52L1 (Tumor Protein D52-Like 1) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Vesicle-mediated transport. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is TPD52.

Gene Wiki entry for TPD52L1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPD52L1 Gene

Genomics for TPD52L1 Gene

Regulatory Elements for TPD52L1 Gene

Enhancers for TPD52L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TPD52L1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TPD52L1 gene promoter:

Genomic Location for TPD52L1 Gene

Chromosome:
6
Start:
125,119,049 bp from pter
End:
125,264,407 bp from pter
Size:
145,359 bases
Orientation:
Plus strand

Genomic View for TPD52L1 Gene

Genes around TPD52L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPD52L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPD52L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPD52L1 Gene

Proteins for TPD52L1 Gene

  • Protein details for TPD52L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16890-TPD53_HUMAN
    Recommended name:
    Tumor protein D53
    Protein Accession:
    Q16890
    Secondary Accessions:
    • A8K757
    • A8K772
    • A8MUD2
    • A8MUJ7
    • A8MW70
    • F6V707
    • O43397
    • Q5TC99
    • Q5TDQ0
    • Q9BUQ6
    • Q9C054

    Protein attributes for TPD52L1 Gene

    Size:
    204 amino acids
    Molecular mass:
    22449 Da
    Quaternary structure:
    • Forms a homodimer or heterodimer with other members of the family.
    SequenceCaution:
    • Sequence=AAC98475.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TPD52L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPD52L1 Gene

Post-translational modifications for TPD52L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for TPD52L1 Gene

Domains & Families for TPD52L1 Gene

Protein Domains for TPD52L1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TPD52L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16890

UniProtKB/Swiss-Prot:

TPD53_HUMAN :
  • Belongs to the TPD52 family.
Family:
  • Belongs to the TPD52 family.
genes like me logo Genes that share domains with TPD52L1: view

No data available for Gene Families for TPD52L1 Gene

Function for TPD52L1 Gene

Molecular function for TPD52L1 Gene

GENATLAS Biochemistry:
tumor protein D52-like 1,breast carcinoma associated (hD53)

Gene Ontology (GO) - Molecular Function for TPD52L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9484778
GO:0042802 identical protein binding IPI 9484778
GO:0042803 protein homodimerization activity IDA 9484778
GO:0046982 protein heterodimerization activity IDA 9484778
genes like me logo Genes that share ontologies with TPD52L1: view
genes like me logo Genes that share phenotypes with TPD52L1: view

Animal Model Products

CRISPR Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPD52L1 Gene

Localization for TPD52L1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPD52L1 Gene COMPARTMENTS Subcellular localization image for TPD52L1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TPD52L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12963375
GO:0048471 perinuclear region of cytoplasm IDA 12963375
genes like me logo Genes that share ontologies with TPD52L1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TPD52L1 Gene

Pathways & Interactions for TPD52L1 Gene

genes like me logo Genes that share pathways with TPD52L1: view

Gene Ontology (GO) - Biological Process for TPD52L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IDA 16112108
GO:0043406 positive regulation of MAP kinase activity IDA 14761963
GO:0046330 positive regulation of JNK cascade IDA 14761963
GO:2001235 positive regulation of apoptotic signaling pathway IDA 14761963
genes like me logo Genes that share ontologies with TPD52L1: view

No data available for SIGNOR curated interactions for TPD52L1 Gene

Drugs & Compounds for TPD52L1 Gene

No Compound Related Data Available

Transcripts for TPD52L1 Gene

Unigene Clusters for TPD52L1 Gene

Tumor protein D52-like 1:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPD52L1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - - - - - - -
SP6: - - - -
SP7: - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - -
SP10: - - - - - -
SP11: - - - - -

Relevant External Links for TPD52L1 Gene

GeneLoc Exon Structure for
TPD52L1
ECgene alternative splicing isoforms for
TPD52L1

Expression for TPD52L1 Gene

mRNA expression in normal human tissues for TPD52L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TPD52L1 Gene

This gene is overexpressed in Adrenal Gland (x5.2).

Protein differential expression in normal tissues from HIPED for TPD52L1 Gene

This gene is overexpressed in Skin (46.5) and Salivary gland (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TPD52L1 Gene



NURSA nuclear receptor signaling pathways regulating expression of TPD52L1 Gene:

TPD52L1

SOURCE GeneReport for Unigene cluster for TPD52L1 Gene:

Hs.591347
genes like me logo Genes that share expression patterns with TPD52L1: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TPD52L1 Gene

Orthologs for TPD52L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPD52L1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TPD52L1 34
  • 89.87 (n)
  • 91.67 (a)
TPD52L1 35
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPD52L1 34
  • 90.86 (n)
  • 93.71 (a)
TPD52L1 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tpd52l1 34
  • 88.4 (n)
  • 90.69 (a)
Tpd52l1 16
Tpd52l1 35
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TPD52L1 34
  • 99.35 (n)
  • 99.51 (a)
TPD52L1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tpd52l1 34
  • 88.75 (n)
  • 93.25 (a)
oppossum
(Monodelphis domestica)
Mammalia TPD52L1 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TPD52L1 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves TPD52L1 34
  • 78.43 (n)
  • 83.82 (a)
TPD52L1 35
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TPD52L1 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tpd52l1 34
  • 66.34 (n)
  • 72.41 (a)
zebrafish
(Danio rerio)
Actinopterygii tpd52l1 34
  • 63.79 (n)
  • 63.79 (a)
tpd52l1 35
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5174 35
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F13E6.1 35
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9626 35
  • 32 (a)
OneToMany
Species where no ortholog for TPD52L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPD52L1 Gene

ENSEMBL:
Gene Tree for TPD52L1 (if available)
TreeFam:
Gene Tree for TPD52L1 (if available)

Paralogs for TPD52L1 Gene

Paralogs for TPD52L1 Gene

(5) SIMAP similar genes for TPD52L1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TPD52L1: view

Variants for TPD52L1 Gene

Sequence variations from dbSNP and Humsavar for TPD52L1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs6905231 - 125,229,167(+) AGAAA(A/G)GCATC reference, missense
rs911190 -- 125,258,620(+) ATAAA(G/T)AACAA intron-variant, utr-variant-3-prime
rs957371 -- 125,255,771(+) ACAAG(G/T)GCCTT intron-variant
rs957372 -- 125,255,918(+) AATGG(G/T)GGTGA intron-variant
rs959905 -- 125,255,899(+) AGGAG(C/T)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPD52L1 Gene

Variant ID Type Subtype PubMed ID
dgv3382n106 CNV deletion 24896259
esv2677911 CNV deletion 23128226
esv2732675 CNV deletion 23290073
esv2732676 CNV deletion 23290073
esv2732677 CNV deletion 23290073
esv2732678 CNV deletion 23290073
esv3302861 CNV tandem duplication 20981092
esv3363615 CNV insertion 20981092
esv3424415 CNV insertion 20981092
esv3540430 CNV deletion 23714750
esv3576230 CNV gain 25503493
esv3610682 CNV gain 21293372
esv3610683 CNV gain 21293372
esv3610684 CNV loss 21293372
esv3890943 CNV gain 25118596
nsv1029255 CNV gain 25217958
nsv1123267 CNV deletion 24896259
nsv1140692 CNV deletion 24896259
nsv1161450 CNV duplication 26073780
nsv604600 CNV gain 21841781
nsv830795 CNV loss 17160897
nsv950503 CNV deletion 24416366

Variation tolerance for TPD52L1 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPD52L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TPD52L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPD52L1 Gene

Disorders for TPD52L1 Gene

Relevant External Links for TPD52L1

Genetic Association Database (GAD)
TPD52L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPD52L1

No disorders were found for TPD52L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPD52L1 Gene

Publications for TPD52L1 Gene

  1. Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52). (PMID: 8812487) Byrne J.A. … Basset P. (Genomics 1996) 2 3 4 22 65
  2. D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells. (PMID: 16112108) Boutros R. … Byrne J.A. (Exp. Cell Res. 2005) 2 3 22 65
  3. Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system. (PMID: 9484778) Byrne J.A. … Gunning P. (Oncogene 1998) 3 4 22 65
  4. A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins. (PMID: 16631610) Cao Q. … Li J. (Biochem. Biophys. Res. Commun. 2006) 3 22 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65

Products for TPD52L1 Gene

Sources for TPD52L1 Gene

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