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Aliases for TPD52 Gene

Aliases for TPD52 Gene

  • Tumor Protein D52 2 3 5
  • Protein N8 3 4
  • Prostate And Colon Associated Protein 3
  • Prostate Leucine Zipper 3
  • PC-1 3
  • PrLZ 3
  • HD52 3
  • D52 3
  • N8L 3

External Ids for TPD52 Gene

Previous GeneCards Identifiers for TPD52 Gene

  • GC08M079835
  • GC08M080995
  • GC08M080670
  • GC08M080997
  • GC08M081110
  • GC08M076436
  • GC08M080870

Summaries for TPD52 Gene

GeneCards Summary for TPD52 Gene

TPD52 (Tumor Protein D52) is a Protein Coding gene. Diseases associated with TPD52 include Nodular Malignant Melanoma. Among its related pathways are Clathrin derived vesicle budding and Vesicle-mediated transport. GO annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is TPD52L3.

Gene Wiki entry for TPD52 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPD52 Gene

Genomics for TPD52 Gene

Regulatory Elements for TPD52 Gene

Enhancers for TPD52 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TPD52 on UCSC Golden Path with GeneCards custom track

Genomic Location for TPD52 Gene

80,034,745 bp from pter
80,231,232 bp from pter
196,488 bases
Minus strand

Genomic View for TPD52 Gene

Genes around TPD52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPD52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPD52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPD52 Gene

Proteins for TPD52 Gene

  • Protein details for TPD52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor protein D52
    Protein Accession:
    Secondary Accessions:
    • B7Z414
    • C9J502
    • D0UFD1
    • D0UFD2
    • D0UFD3
    • D0UFD4
    • D0UFD5
    • E5RKB4
    • Q13056
    • Q53EK8
    • Q6FGP3
    • Q6FGS3
    • Q86YZ2
    • Q9UCX8

    Protein attributes for TPD52 Gene

    224 amino acids
    Molecular mass:
    24327 Da
    Quaternary structure:
    • Forms a homodimer or heterodimer with other members of the family. All isoforms interact with several 14-3-3 proteins.
    • Sequence=BAD97351.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TPD52 Gene

neXtProt entry for TPD52 Gene

Proteomics data for TPD52 Gene at MOPED

Post-translational modifications for TPD52 Gene

  • Ubiquitination at Lys 125 and Lys 149
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TPD52 Gene

Domains & Families for TPD52 Gene

Protein Domains for TPD52 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TPD52 family.
  • Belongs to the TPD52 family.
genes like me logo Genes that share domains with TPD52: view

No data available for Gene Families for TPD52 Gene

Function for TPD52 Gene

Molecular function for TPD52 Gene

GENATLAS Biochemistry:
tumor protein D52,breast carcinoma associated

Gene Ontology (GO) - Molecular Function for TPD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046982 protein heterodimerization activity IDA 9484778
genes like me logo Genes that share ontologies with TPD52: view
genes like me logo Genes that share phenotypes with TPD52: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPD52 Gene

Localization for TPD52 Gene

Subcellular locations from

Jensen Localization Image for TPD52 Gene COMPARTMENTS Subcellular localization image for TPD52 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 4
golgi apparatus 3
nucleus 2
plasma membrane 2
extracellular 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TPD52 Gene

Pathways & Interactions for TPD52 Gene

genes like me logo Genes that share pathways with TPD52: view

SIGNOR curated interactions for TPD52 Gene

Other effect:

Gene Ontology (GO) - Biological Process for TPD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046903 secretion TAS 15576473
genes like me logo Genes that share ontologies with TPD52: view

Drugs & Compounds for TPD52 Gene

(1) Additional Compounds for TPD52 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TPD52: view

Transcripts for TPD52 Gene

Unigene Clusters for TPD52 Gene

Tumor protein D52:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPD52 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d · 13e · 13f · 13g · 13h
SP1: - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - -
SP10: - - -
SP11: - -

Relevant External Links for TPD52 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPD52 Gene

mRNA expression in normal human tissues for TPD52 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TPD52 Gene

This gene is overexpressed in Oral epithelium (13.6), Salivary gland (9.0), and Islet of Langerhans (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPD52 Gene

SOURCE GeneReport for Unigene cluster for TPD52 Gene Hs.368433

mRNA Expression by UniProt/SwissProt for TPD52 Gene

Tissue specificity: Isoform 2 is expressed in colon, breast, prostate, pancreas and kidney tumor cell lines. Isoform 2 is expressed at high levels in kidney, prostate, brain, small intestine and pancreas, at moderate levels in placenta and colon, at low levels in lung, liver and heart, and at very low levels in spleen, thymus, peripheral mononuclear blood cells, testis and ovary.
genes like me logo Genes that share expression patterns with TPD52: view

Protein tissue co-expression partners for TPD52 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for TPD52 Gene

Orthologs for TPD52 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPD52 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TPD52 35
  • 91.82 (n)
  • 93.75 (a)
TPD52 36
  • 85 (a)
(Mus musculus)
Mammalia Tpd52 35
  • 82.31 (n)
  • 86.12 (a)
Tpd52 16
Tpd52 36
  • 76 (a)
(Pan troglodytes)
Mammalia TPD52 35
  • 99.87 (n)
  • 99.6 (a)
TPD52 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tpd52 35
  • 84.23 (n)
  • 87.39 (a)
(Canis familiaris)
Mammalia TPD52 36
  • 85 (a)
(Monodelphis domestica)
Mammalia TPD52 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia TPD52 36
  • 58 (a)
(Gallus gallus)
Aves TPD52 35
  • 78.21 (n)
  • 86.03 (a)
TPD52 36
  • 72 (a)
(Anolis carolinensis)
Reptilia TPD52 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17690 35
tpd52 35
  • 70.26 (n)
  • 73.65 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10244 35
(Danio rerio)
Actinopterygii Dr.14430 35
tpd52 35
  • 64.68 (n)
  • 63.1 (a)
tpd52 36
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5174 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea F13E6.1 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9626 36
  • 37 (a)
Species with no ortholog for TPD52:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPD52 Gene

Gene Tree for TPD52 (if available)
Gene Tree for TPD52 (if available)

Paralogs for TPD52 Gene

Paralogs for TPD52 Gene

genes like me logo Genes that share paralogs with TPD52: view

Variants for TPD52 Gene

Sequence variations from dbSNP and Humsavar for TPD52 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs35099105 - 80,064,579(+) TGGGT(A/C)TGTTC intron-variant, nc-transcript-variant, reference, missense
rs2033064 -- 80,129,002(+) AGCCT(C/T)TGAAG intron-variant
rs2033065 -- 80,137,906(+) gcact(C/T)cagcc intron-variant
rs2033066 -- 80,138,188(+) tccgc(C/T)cgcct intron-variant
rs2033067 -- 80,139,038(+) AGTCT(C/G)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPD52 Gene

Variant ID Type Subtype PubMed ID
nsv891061 CNV Loss 21882294
esv2737216 CNV Deletion 23290073
esv9040 CNV Gain 19470904
esv33694 CNV Gain 17666407
nsv518684 CNV Gain 19592680

Variation tolerance for TPD52 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.47% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TPD52 Gene

Disorders for TPD52 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TPD52 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nodular malignant melanoma
  • nodular melanoma
- elite association - COSMIC cancer census association via MalaCards
Search TPD52 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TPD52

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TPD52: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPD52 Gene

Publications for TPD52 Gene

  1. A screening method to identify genes commonly overexpressed in carcinomas and the identification of a novel complementary DNA sequence. (PMID: 7796418) Byrne J.A. … Basset P. (Cancer Res. 1995) 2 3 4 67
  2. [PC-1 enhances c-myc gene expression in prostate cancer cells]. (PMID: 20423888) Yu L. … Zhou J.G. (Yi Chuan 2010) 3 23
  3. Nonredundant functions for tumor protein D52-like proteins support specific targeting of TPD52. (PMID: 18698023) Shehata M. … Byrne J.A. (Clin. Cancer Res. 2008) 3 23
  4. Expression of chloride intracellular channel protein 1 (CLIC1) and tumor protein D52 (TPD52) as potential biomarkers for colorectal cancer. (PMID: 18710659) Petrova D.T. … Toncheva D. (Clin. Biochem. 2008) 3 23
  5. Altered expression of tumor protein D52 regulates apoptosis and migration of prostate cancer cells. (PMID: 18959755) Ummanni R. … Walther R. (FEBS J. 2008) 3 23

Products for TPD52 Gene

Sources for TPD52 Gene