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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TPD52 Gene

protein-coding   GIFtS: 59
GCID: GC08M080870

tumor protein D52
 Explore 16 diseases affiliated with
TPD52 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TPD52    

Aliases
for TPD52 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tumor Protein D521 2     PC-12
D521 2     PrLZ2
N8L1 2     Prostate And Colon Associated Protein2
HD521     Prostate Leucine Zipper2
Protein N82 3     

External Ids:    HGNC: 120051   Entrez Gene: 71632   Ensembl: ENSG000000765547   OMIM: 6040685   UniProtKB: P553273   

Export aliases for TPD52 gene to outside databases

Previous GC identifers: GC08M079835 GC08M080995 GC08M080670 GC08M080997 GC08M081110 GC08M076436


Summaries
for TPD52 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Gene Wiki entry for TPD52


Genomic Views
for TPD52 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TPD52 gene promoter:
         GR   AML1a   Brachyury   GR-beta   Lmo2   MyoD   Tal-1beta   YY1   GR-alpha   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TPD52 promoter sequence
   Search SABiosciences Chromatin IP Primers for TPD52

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPD52


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q21

TPD52 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPD52 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M080870:  view genomic region     (about GC identifiers)

Start:
 80,870,571 bp from pter      End:
 81,143,467 bp from pter
Size:
 272,897 bases      Orientation:
 minus strand

Proteins
for TPD52 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TPD52_HUMAN, P55327 (See protein sequence)
Recommended Name: Tumor protein D52  
Size: 224 amino acids; 24327 Da
Subunit: Forms a homodimer or heterodimer with other members of the family
Developmental stage: Isoform 2 is expressed at lower levels in fetal brain and kidney than in adult brain and kidney
Sequence caution: Sequence=BAD97351.1; Type=Erroneous initiation;
Secondary accessions: B7Z414 E5RKB4 Q13056 Q53EK8 Q6FGP3 Q6FGS3 Q86YZ2 Q9UCX8
Alternative splicing: 4 isoforms:  P55327-1   P55327-2   P55327-3   P55327-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TPD52: NX_P55327

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P55327

    • TPD52 Protein expression data from MOPED and PaxDb:    About this image 
    TPD52 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001020423.1  NP_001020424.1  NP_005070.1  

    ENSEMBL proteins: 
     ENSP00000368390   ENSP00000429915   ENSP00000429309   ENSP00000429351   ENSP00000429708  
     ENSP00000368391   ENSP00000428951   ENSP00000430646   ENSP00000430421   ENSP00000430323  
     ENSP00000430140   ENSP00000430865   ENSP00000438113   ENSP00000410222   ENSP00000441806  
    Reactome Protein details: P55327
    Human Recombinant Protein Products for TPD52: 
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    Novus Biologicals TPD52 Proteins
    Novus Biologicals TPD52 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TPD52

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15576473
    GO:0005783endoplasmic reticulum IDA10942595
    GO:0048471perinuclear region of cytoplasm IDA16112108

    TPD52 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TPD52

    Protein Domains /
    Families
    for TPD52 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TPD52 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007327 TPD52

    Graphical View of Domain Structure for InterPro Entry P55327

    ProtoNet protein and cluster: P55327

    1 Blocks protein family: IPB007327 Tumor protein D52

    UniProtKB/Swiss-Prot: TPD52_HUMAN, P55327
    Similarity: Belongs to the TPD52 family


    Function
    for TPD52 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:
         Genatlas biochemistry entry for TPD52:
    tumor protein D52,breast carcinoma associated

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IDA15576473
    GO:0005515protein binding IPI9484778
    GO:0042803protein homodimerization activity IDA9484778
    GO:0046982protein heterodimerization activity IDA9484778
         
    TPD52 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TPD52 

    miRNA
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    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate TPD52 (see all 52):
    hsa-miR-194* hsa-miR-576-3p hsa-miR-100* hsa-miR-139-5p hsa-miR-138-2* hsa-miR-218 hsa-miR-449a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: TPD52 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TPD52 (see all 7)
    OriGene shRNA RFP: TPD52
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPD52 (see all 11)
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPD52


    Pathways & Interactions
    for TPD52 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Clathrin derived vesicle budding
    		trans-Golgi Network Vesicle Budding1.00
    		Golgi Associated Vesicle Biogenesis0.89
    		Clathrin derived vesicle budding1.00
    2Membrane Trafficking
    		Membrane Trafficking1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for TPD52
        Membrane Trafficking
    Clathrin derived vesicle budding
    Golgi Associated Vesicle Biogenesis
    trans-Golgi Network Vesicle Budding



    TPD52 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TPD52

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/14 Interacting proteins for TPD52 (P553271, 2, 3 ENSP000003683914) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TPD52L1Q168901, 3, ENSP000003573874EBI-782581,EBI-782694 I2D: score=4 STRING: ENSP00000357387
    YWHAZP631042, 3, ENSP000003095034MINT-3307546 I2D: score=1 STRING: ENSP00000309503
    TPD52L2O433993, ENSP000002171214I2D: score=3 STRING: ENSP00000217121
    TPD52L3Q96J773, ENSP000003416774I2D: score=2 STRING: ENSP00000341677
    ANXA6P081333, ENSP000003465504I2D: score=2 STRING: ENSP00000346550
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009653anatomical structure morphogenesis TAS8632896
    GO:0030183B cell differentiation IEP15576473
    GO:0046903secretion TAS15576473

    TPD52 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TPD52 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TPD52 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TPD52
    1 Novoseek chemical compound relationship for TPD52 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polyacrylamide 28 3 9372899 (1), 15576473 (1)

    Search CenterWatch for drugs/clinical trials and news about TPD52 

    Transcripts
    for TPD52 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TPD52 gene (3 alternative transcripts): 
    NM_001025252.1  NM_001025253.1  NM_005079.2  

    Unigene Cluster for TPD52:

    Tumor protein D52
    Hs.368433  [show with all ESTs]
    Unigene Representative Sequence: NM_001025252
    18/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000379096(uc003ybq.1 uc003ybr.1 uc022awm.1 uc022awn.1 uc022awo.1 uc022awp.1 uc010lzs.1 uc003ybs.1 uc003ybt.1)
    ENST00000518937 ENST00000520527 ENST00000517427 ENST00000517462 ENST00000379097
    ENST00000523319 ENST00000519303 ENST00000523395 ENST00000523193 ENST00000521354
    ENST00000520877 ENST00000521618 ENST00000518517 ENST00000524194 ENST00000517445
    ENST00000521241 ENST00000523753

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TPD52
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate TPD52 (see all 52):
    hsa-miR-194* hsa-miR-576-3p hsa-miR-100* hsa-miR-139-5p hsa-miR-138-2* hsa-miR-218 hsa-miR-449a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: TPD52 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TPD52 (see all 7)
    OriGene shRNA RFP: TPD52
    OriGene siRNA: TPD52
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    Sirion Biotech Custom design and validation of potent shRNA sequences against TPD52 
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPD52

    Additional cDNA sequence: 

    AF202897.1 AK057075.1 AK223631.1 AK295468.1 AK296615.1 AK308983.1 AK313135.1 BC018117.1 
    BT019444.1 BX640835.1 CR542034.1 CR542064.1 EF152584.1 GQ499324.1 GQ499325.1 GQ499326.1 
    GQ499327.1 GQ499328.1 S82081.1 U18914.1 

    24/25 DOTS entries (see all 25):

    DT.95261932  DT.117299  DT.95261928  DT.101969586  DT.120648588  DT.120648556  DT.100827038  DT.120648587 
    DT.120648511  DT.120648567  DT.95261930  DT.120648620  DT.434112  DT.91885426  DT.95261926  DT.75118581 
    DT.95315786  DT.100030168  DT.101974971  DT.120648523  DT.120648621  DT.91683132  DT.95261925  DT.95290503 

    24/383 AceView cDNA sequences (see all 383):

    NM_005079 BU153442 C20724 N73503 AI632972 AU104441 AI922688 BM927243 
    AI249930 AW135527 BQ878165 BI600172 BU162860 AA761332 BQ640567 BU783828 
    BM478742 AW117230 AI492144 N50424 AA640129 BQ690015 AI220977 BM693965 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TPD52 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d · 13e · 13f · 13g · 13h
    SP1:              -     -     -     -     -                             -     -           -                                                                     
    SP2:              -     -     -     -     -                             -     -           -     -     -                                                         
    SP3:              -     -     -     -     -     -                       -     -           -     -     -                                                         
    SP4:                                -     -                             -     -           -     -     -                                                         
    SP5:                                                                    -     -           -     -     -                                                         


    ECgene alternative splicing isoforms for TPD52

    Expression
    for TPD52 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TPD52 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAAAAGCTT
    TPD52 Expression
    About this image

    TPD52 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    Gut TubeMidgutGut Tube
    LungTracheaLung
    Neural TubeMetencephalonNeural Tube
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See TPD52 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TPD52

    SOURCE GeneReport for Unigene cluster: Hs.368433

    UniProtKB/Swiss-Prot: TPD52_HUMAN, P55327
    Tissue specificity: Isoform 2 is expressed in colon, breast, prostate, pancreas and kidney tumor cell lines. Isoform 2
    is expressed at high levels in kidney, prostate, brain, small intestine and pancreas, at moderate levels in placenta
    and colon, at low levels in lung, liver and heart, and at very low levels in spleen, thymus, peripheral mononuclear
    blood cells, testis and ovary

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    In Situ
    Assay Products:     
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    Orthologs
    for TPD52 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TPD52 gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tpd521 , 5 tumor protein D521, 5 81.38(n)1
    84.68(a)1    		   3 (2.23 cM)5
    219851  NM_001025262.11  NP_001020433.11 
     89286265 
    chicken
    (Gallus gallus)    		 Aves TPD521 tumor protein D52 78.21(n)
    86.03(a)    		   770339  NM_001079754.1  NP_001073222.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TPD526
    		 --
    		 52(a)
    		 1 ↔ 1
    		 4(25037073-25066802)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.102442 Xenopus laevis transcribed sequence with moderate similarity more 80.9(n)    CF547482.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.144302 Transcribed sequence with weak similarity to protein more 75(n)    BG737858.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG51746
    		 --
    		 14(a)
    		 1 → many
    		 2R(14308915-14313732)
    worm
    (Caenorhabditis elegans)    		 Secernentea F13E6.16
    		 Uncharacterized protein F13E6.1
    		 31(a)
    		 1 → many
    		 X(10675636-10677048)


    ENSEMBL Gene Tree for TPD52 (if available)
    TreeFam Gene Tree for TPD52 (if available) 

    Paralogs
    for TPD52 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TPD52 gene
    TPD52L32  TPD52L22  TPD52L12  
    7 SIMAP similar genes for TPD52 using alignment to 8 protein entries:     TPD52_HUMAN (see all proteins):
    MRPS28    PrLZ    TPD52L1    DKFZp686A1765    hD53    TPD52L3
    TPD52L2

    TPD52 for paralogs           About GeneDecksing



    Genomic Variants
    for TPD52 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2464 NCBI SNPs in TPD52 are shown (see all 2464)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1841641401,2
    		--80946653(+) CTGCAA/GCCCCC 3 -- ds5001 int10--------
    rs1161432261,2
    		F--80946664(+) CAGCCA/CTGCTT 3 -- int1 ds50011Minor allele frequency- C:0.03WA 118
    rs1401659581,2
    		--80947002(+) AAAACC/TGTATT 3 -- int1 ds50010--------
    rs1456978041,2
    		--80947060(+) TACCAA/GCCAAC 3 -- int1 ds50010--------
    rs749294251,2
    		F--80947079(+) CATCAA/CAATTA 3 -- int1 ds50012Minor allele frequency- C:0.06WA NA 238
    rs780547281,2
    		C,F--80947140(+) AAAATC/TCTGGC 3 -- ut311Minor allele frequency- T:0.03WA 118
    rs1997700081,2
    		C--80947155(-) CAAGTG/TCTTTT 3 -- ut310--------
    rs1487300281,2
    		--80947168(+) GACCCA/GACTCT 3 -- ut310--------
    rs1125449791,2
    		C--80947184(+) AACTTACAA/-  
                ACAAA     		3 -- ut311Minor allele frequency- -:0.50CSA 2
    rs1898696251,2
    		--80947382(+) CACTAG/TGGGCA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for TPD52 (80870571 - 81120571 bp, first 250kb of TPD52)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for TPD52
         2 Indels: 11330 60718

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPD52
    DNA2.0 Custom Variant and Variant Library Synthesis for TPD52

    Disorders / Diseases
    for TPD52 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TPD52 for disorders           About GeneDecksing

    OMIM gene information: 604068    OMIM disorders: --

    16 diseases for TPD52:    About MalaCards
    prostatitis    ataxia telangiectasia    childhood leukemia    prostate cancer
    prostate cancer, progression of    ovarian cancer    breast carcinoma    gout
    breast cancer    ataxia    ovarian carcinoma    colorectal cancer
    carcinoma    sarcoma    leukemia    melanoma

    8 Novoseek disease relationships for TPD52 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 52.9 36 17418805 (5), 15172988 (5), 14996714 (5), 16159422 (4) (see all 10)
    breast carcinoma 51.5 20 10918393 (5), 18698023 (2), 9484778 (2), 9838088 (1) (see all 5)
    tumors 39.6 69 15986428 (3), 12526213 (3), 18698023 (3), 18959755 (2) (see all 24)
    breast cancer 24.6 11 18698023 (2), 12747765 (2), 18959755 (1), 17487680 (1) (see all 7)
    benign prostatic hyperplasia 24.2 1 9372899 (1)
    cancer 21.7 14 18698023 (2), 12526213 (1), 19105569 (1), 19169682 (1) (see all 6)
    metastasis 15.6 8 19169682 (2), 17314271 (1), 12526213 (1), 17962942 (1)
    ovarian cancer 11 4 15986428 (2)

    Human Genome Epidemiology (HuGE) Navigator: TPD52 (4 documents)

    Export disorders for TPD52 gene to outside databases

    Publications
    for TPD52 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TPD52 gene, integrated from 9 sources (see all 73):
    (articles sorted by number of sources associating them with TPD52)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A screening method to identify genes commonly overexpressed in carcinomas and the identification of a novel complementary DNA sequence. (PubMed id 7796418)1, 2, 3 Byrne J.A.... Basset P. (1995)
    2. PrLZ, a novel prostate-specific and androgen-responsive gene of the TPD52 family, amplified in chromosome 8q21.1 and overexpressed in human prostate cancer. (PubMed id 14996714)1, 2, 9 Wang R.... Chung L.W. (2004)
    3. Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system. (PubMed id 9484778)1, 2, 9 Byrne J.A.... Gunning P. (1998)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Isolation and characterization of a novel gene expressed in multiple cancers. (PubMed id 8632896)1, 2 Chen S.-L.... Bhat N.K. (1996)
    8. Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52). (PubMed id 8812487)1, 9 Byrne J.A.... Basset P. (1996)
    9. Tumor protein D52 (TPD52) is overexpressed and a gene amplification target in ovarian cancer. (PubMed id 15986428)1, 9 Byrne J.A....Defazio A. (2005)
    10. Nonredundant functions for tumor protein D52-like proteins support specific targeting of TPD52. (PubMed id 18698023)1, 9 Shehata M....Byrne J.A. (2008)

    External Searches for TPD52 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TPD52 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7163 HGNC: 12005 AceView: TPD52 Ensembl:ENSG00000076554 euGenes: HUgn7163
    ECgene: TPD52 H-InvDB: TPD52

    Other Databases showing TPD52 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TPD52 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TPD52 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TPD52 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TPD52 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TPD52 gene:
    Search GeneIP for patents involving TPD52

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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