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TPD52 Gene

protein-coding   GIFtS: 62
GCID: GC08M080870

Tumor Protein D52

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disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Protein D521 2     PrLZ2
Protein N82 3     hD522
D522 5     Prostate And Colon Associated Protein2
N8L2     Prostate Leucine Zipper2
PC-12     

External Ids:    HGNC: 120051   Entrez Gene: 71632   Ensembl: ENSG000000765547   OMIM: 6040685   UniProtKB: P553273   

Export aliases for TPD52 gene to outside databases

Previous GC identifers: GC08M079835 GC08M080995 GC08M080670 GC08M080997 GC08M081110 GC08M076436


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TPD52 Gene:
TPD52 (tumor protein D52) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity and calcium ion binding. An important paralog of this gene is TPD52L3.

Gene Wiki entry for TPD52 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the TPD52 gene promoter:
         GR   AML1a   Brachyury   GR-beta   Lmo2   MyoD   Tal-1beta   YY1   GR-alpha   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TPD52 promoter sequence
   Search Chromatin IP Primers for TPD52

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPD52


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q21

TPD52 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPD52 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M080870:  view genomic region     (about GC identifiers)

Start:
80,870,571 bp from pter      End:
81,143,467 bp from pter
Size:
272,897 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TPD52_HUMAN, P55327 (See protein sequence)
Recommended Name: Tumor protein D52  
Size: 224 amino acids; 24327 Da
Subunit: Forms a homodimer or heterodimer with other members of the family. All isoforms interact with several
14-3-3 proteins
Developmental stage: Isoform 2 is expressed at lower levels in fetal brain and kidney than in adult brain and
kidney
Sequence caution: Sequence=BAD97351.1; Type=Erroneous initiation;
Secondary accessions: B7Z414 C9J502 D0UFD1 D0UFD2 D0UFD3 D0UFD4 D0UFD5 E5RKB4 Q13056 Q53EK8
Q6FGP3 Q6FGS3 Q86YZ2 Q9UCX8
Alternative splicing: 8 isoforms:  P55327-1   P55327-2   P55327-3   P55327-4   P55327-5   P55327-6   P55327-7   P55327-8   
(Interacts only with YWHAB and YWHAQ among 14-3-3 proteins)

Explore the universe of human proteins at neXtProt for TPD52: NX_P55327

Explore proteomics data for TPD52 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys125, Lys149
  • Modification sites at PhosphoSitePlus

  • See TPD52 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001020423.1  NP_001020424.1  NP_001274069.1  NP_001274071.1  NP_001274072.1  NP_001274073.1  NP_005070.1  

    ENSEMBL proteins: 
     ENSP00000368390   ENSP00000429915   ENSP00000429309   ENSP00000429351   ENSP00000429708  
     ENSP00000368391   ENSP00000428951   ENSP00000430646   ENSP00000430421   ENSP00000430323  
     ENSP00000430140   ENSP00000430865   ENSP00000438113   ENSP00000410222  
    Reactome Protein details: P55327

    TPD52 Human Recombinant Protein Products:

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    Novus Biologicals TPD52 Proteins
    Novus Biologicals TPD52 Lysates
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    Cloud-Clone Corp. Proteins for TPD52

     
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    antibodies-online proteins for TPD52 (5 products) 

     
    antibodies-online peptides for TPD52

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    antibodies-online antibodies for TPD52 (43 products) 

    TPD52 Assay Products:

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    Cloud-Clone Corp. CLIAs for TPD52
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    antibodies-online kits for TPD52 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007327 TPD52

    Graphical View of Domain Structure for InterPro Entry P55327

    ProtoNet protein and cluster: P55327

    1 Blocks protein domain: IPB007327 Tumor protein D52

    UniProtKB/Swiss-Prot: TPD52_HUMAN, P55327
    Similarity: Belongs to the TPD52 family


    Find genes that share domains with TPD52           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for TPD52:
    tumor protein D52,breast carcinoma associated

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IDA15576473
    GO:0005515protein binding IPI12963375
    GO:0042803protein homodimerization activity IDA9484778
    GO:0046982protein heterodimerization activity IDA9484778
         
    Find genes that share ontologies with TPD52           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TPD52

    miRNA
    Products:
        
    miRTarBase miRNAs that target TPD52:
    hsa-mir-15b-5p (MIRT046423), hsa-mir-218-5p (MIRT024215), hsa-mir-505-3p (MIRT041053), hsa-mir-155-5p (MIRT021038), hsa-mir-103a-3p (MIRT027218), hsa-mir-34a-5p (MIRT025584)

    Block miRNA regulation of human, mouse, rat TPD52 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TPD52 (see all 52):
    hsa-miR-194* hsa-miR-576-3p hsa-miR-100* hsa-miR-139-5p hsa-miR-138-2* hsa-miR-218 hsa-miR-449a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidTPD52 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TPD52
    Predesigned siRNA for gene silencing in human, mouse, rat TPD52

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): TPD52 (NM_001025252)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TPD52
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPD52

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPD52


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol2
    nucleus2
    extracellular1
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15576473
    GO:0005783endoplasmic reticulum IDA10942595
    GO:0048471perinuclear region of cytoplasm IDA16112108

    Find genes that share ontologies with TPD52           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TPD52 About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    Membrane Trafficking0.32


    Find genes that share SuperPaths with TPD52           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for TPD52
        Golgi Associated Vesicle Biogenesis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TPD52
    Interactions:

        GeneGlobe Interaction Network for TPD52

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for TPD52 (P553271, 2, 3 ENSP000003683914) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TPD52L1Q168901, 3, ENSP000003573874EBI-782581,EBI-717470 I2D: score=4 STRING: ENSP00000357387
    YWHAZP631042, 3, ENSP000003095034MINT-3307546 I2D: score=1 STRING: ENSP00000309503
    TPD52L2O433993, ENSP000002171214I2D: score=3 STRING: ENSP00000217121
    TPD52L3Q96J773, ENSP000003416774I2D: score=2 STRING: ENSP00000341677
    ANXA6P081333, ENSP000003465504I2D: score=2 STRING: ENSP00000346550
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009653anatomical structure morphogenesis TAS8632896
    GO:0030183B cell differentiation IEP15576473
    GO:0046903secretion TAS15576473

    Find genes that share ontologies with TPD52           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TPD52

    1 Novoseek inferred chemical compound relationship for TPD52 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polyacrylamide 28 3 9372899 (1), 15576473 (1)



    Find genes that share compounds with TPD52           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TPD52 gene (7 alternative transcripts): 
    NM_001025252.2  NM_001025253.2  NM_001287140.1  NM_001287142.1  NM_001287143.1  NM_001287144.1  NM_005079.3  

    Unigene Cluster for TPD52:

    Tumor protein D52
    Hs.368433  [show with all ESTs]
    Unigene Representative Sequence: NM_001025252
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000379096(uc003ybq.1 uc003ybr.1 uc022awm.1 uc022awn.1 uc022awo.1 uc022awp.1 uc010lzs.1 uc003ybs.1 uc003ybt.1)
    ENST00000518937 ENST00000520527 ENST00000517427 ENST00000517462 ENST00000379097
    ENST00000519303 ENST00000523395 ENST00000523193 ENST00000523319 ENST00000521354
    ENST00000520877 ENST00000521618 ENST00000518517 ENST00000524194 ENST00000521241
    ENST00000517445 ENST00000523753
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TPD52 (see all 52):
    hsa-miR-194* hsa-miR-576-3p hsa-miR-100* hsa-miR-139-5p hsa-miR-138-2* hsa-miR-218 hsa-miR-449a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidTPD52 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): TPD52 (NM_001025252)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPD52
    Primer
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    OriGene qPCR primer pairs and template standards for TPD52
    OriGene qSTAR qPCR primer pairs in human, mouse for TPD52
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TPD52
      QuantiTect SYBR Green Assays in human, mouse, rat TPD52
      QuantiFast Probe-based Assays in human, mouse, rat TPD52

    Additional mRNA sequence: 

    AF202897.1 AK057075.1 AK223631.1 AK295468.1 AK296615.1 AK308983.1 AK313135.1 BC018117.1 
    BT019444.1 BX640835.1 CR542034.1 CR542064.1 EF152584.1 GQ499324.1 GQ499325.1 GQ499326.1 
    GQ499327.1 GQ499328.1 S82081.1 U18914.1 

    Selected DOTS entries (see all 26):

    DT.95261932  DT.117299  DT.95261928  DT.101969586  DT.120648588  DT.120648556  DT.100827038  DT.120648587 
    DT.120648511  DT.120648567  DT.95261930  DT.120648620  DT.434112  DT.91885426  DT.95261926  DT.120648621 
    DT.75118581  DT.95315786  DT.100030168  DT.101974971  DT.120648523  DT.91683132  DT.95261925  DT.95290503 

    Selected AceView cDNA sequences (see all 383):

    BU783828 BE047200 BM847502 CB991894 BI667107 AI744076 BM927243 BQ423925 
    BU677260 BI599347 AI220977 AW949405 AI092437 CB996659 AI334712 U18914 
    AA504402 AI492144 BE326261 AA364540 BX100509 BQ640567 BX505127 AA505975 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TPD52 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d · 13e · 13f · 13g · 13h
    SP1:              -     -     -     -     -                             -     -           -                                                                     
    SP2:              -     -     -     -     -                             -     -           -     -     -                                                         
    SP3:              -     -     -     -     -     -                       -     -           -     -     -                                                         
    SP4:                                -     -                             -     -           -     -     -                                                         
    SP5:                                                                    -     -           -     -     -                                                         


    ECgene alternative splicing isoforms for TPD52

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TPD52 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAAAGCTT
    TPD52 Expression
    About this image


    TPD52 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 6 entries
             hIPS1
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Mature B-Cells Peripheral Blood
             Bone marrow-derived hematopoietic stem cells (family)
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Thymus
    TPD52 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TPD52 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368433

    UniProtKB/Swiss-Prot: TPD52_HUMAN, P55327
    Tissue specificity: Isoform 2 is expressed in colon, breast, prostate, pancreas and kidney tumor cell lines.
    Isoform 2 is expressed at high levels in kidney, prostate, brain, small intestine and pancreas, at moderate
    levels in placenta and colon, at low levels in lung, liver and heart, and at very low levels in spleen, thymus,
    peripheral mononuclear blood cells, testis and ovary

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    QuantiFast Probe-based Assays in human, mouse, rat TPD52
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPD52

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TPD52 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tpd521 , 5 tumor protein D521, 5 82.31(n)1
    86.12(a)1
      3 (2.23 cM)5
    219851  NM_001025261.11  NP_001020432.11 
     89286265 
    chicken
    (Gallus gallus)
    Aves TPD521 tumor protein D52 78.21(n)
    86.03(a)
      770339  NM_001079754.1  NP_001073222.1 
    lizard
    (Anolis carolinensis)
    Reptilia TPD526
    tumor protein D52
    77(a)
    1 ↔ 1
    4(25014429-25051064)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.102442 Xenopus laevis transcribed sequence with moderate similarity more 80.9(n)    CF547482.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.144302 Transcribed sequence with weak similarity to protein more 75(n)    BG737858.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51746
    --
    18(a)
    1 → many
    2R(14308915-14313732)
    worm
    (Caenorhabditis elegans)
    Secernentea F13E6.16
    Protein F13E6.1 (F13E6.1) mRNA, complete cds
    31(a)
    1 → many
    X(10675699-10677109) WBGene00008745


    ENSEMBL Gene Tree for TPD52 (if available)
    TreeFam Gene Tree for TPD52 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TPD52 gene
    TPD52L32  TPD52L22  TPD52L12  
    6 SIMAP similar genes for TPD52 using alignment to 7 protein entries:     TPD52_HUMAN (see all proteins):
    MRPS28    TPD52L1    DKFZp686A1765    hD53    TPD52L2    TPD52L3

    Find genes that share paralogs with TPD52           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TPD52 (see all 2791)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1841641401,2
    --80946653(+) CTGCAA/GCCCCC 3 -- int1 ds50010--------
    rs1161432261,2
    F--80946664(+) CAGCCA/CTGCTT 3 -- int1 ds50011Minor allele frequency- C:0.03WA 118
    rs1401659581,2
    --80947002(+) AAAACC/TGTATT 3 -- int1 ds50010--------
    rs1456978041,2
    --80947060(+) TACCAA/GCCAAC 3 -- int1 ds50010--------
    rs749294251,2
    C,F--80947079(+) CATCAA/CAATTA 3 -- int1 ds50012Minor allele frequency- C:0.06WA NA 238
    rs780547281,2
    C,F--80947140(+) AAAATC/TCTGGC 3 -- ut311Minor allele frequency- T:0.03WA 118
    rs1997700081,2
    C--80947155(-) CAAGTG/TCTTTT 3 -- ut310--------
    rs1487300281,2
    --80947168(+) GACCCA/GACTCT 3 -- ut310--------
    rs1125449791,2
    C--80947184(+) AACTTACAA/-  
            
    ACAAA
    3 -- ut311Minor allele frequency- -:0.50CSA 2
    rs1898696251,2
    C--80947382(+) CACTAG/TGGGCA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for TPD52 (80870571 - 81120571 bp, first 250kb of TPD52)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TPD52:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2737216CNV Deletion23290073
    nsv891061CNV Loss21882294
    esv33694CNV Gain17666407
    nsv518684CNV Gain19592680
    esv9040CNV Gain19470904

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TPD52
    DNA2.0 Custom Variant and Variant Library Synthesis for TPD52

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604068    OMIM disorders: --


    Find genes that share disorders with TPD52           About GenesLikeMe

    8 Novoseek inferred disease relationships for TPD52 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 52.9 36 17418805 (5), 15172988 (5), 14996714 (5), 16159422 (4) (see all 10)
    breast carcinoma 51.5 20 10918393 (5), 18698023 (2), 9484778 (2), 9838088 (1) (see all 5)
    tumors 39.6 69 15986428 (3), 12526213 (3), 18698023 (3), 18959755 (2) (see all 24)
    breast cancer 24.6 11 18698023 (2), 12747765 (2), 18959755 (1), 17487680 (1) (see all 7)
    benign prostatic hyperplasia 24.2 1 9372899 (1)
    cancer 21.7 14 18698023 (2), 12526213 (1), 19105569 (1), 19169682 (1) (see all 6)
    metastasis 15.6 8 19169682 (2), 17314271 (1), 12526213 (1), 17962942 (1)
    ovarian cancer 11 4 15986428 (2)

    Genetic Association Database (GAD): TPD52
    Human Genome Epidemiology (HuGE) Navigator: TPD52 (4 documents)

    Export disorders for TPD52 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TPD52 gene, integrated from 10 sources (see all 84):
    (articles sorted by number of sources associating them with TPD52)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A screening method to identify genes commonly overexpressed in carcinomas and the identification of a novel complementary DNA sequence. (PubMed id 7796418)1, 2, 3 Byrne J.A.... Basset P. (Cancer Res. 1995)
    2. PrLZ, a novel prostate-specific and androgen-responsive gene of the TPD52 family, amplified in chromosome 8q21.1 and overexpressed in human prostate cancer. (PubMed id 14996714)1, 2, 9 Wang R.... Chung L.W. (Cancer Res. 2004)
    3. Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system. (PubMed id 9484778)1, 2, 9 Byrne J.A.... Gunning P. (Oncogene 1998)
    4. Polymorphisms in predicted miRNA binding sites and osteoporosis. (PubMed id 20641033)1, 4 Lei S.F....Deng H.W. (J. Bone Miner. Res. 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Transcription variants of the prostate-specific PrLZ gene and their interaction with 14-3-3 proteins. (PubMed id 19732746)1, 2 Wang R.... He D. (Biochem. Biophys. Res. Commun. 2009)
    7. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7163 HGNC: 12005 AceView: TPD52 Ensembl:ENSG00000076554 euGenes: HUgn7163
    ECgene: TPD52 H-InvDB: TPD52

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TPD52 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TPD52 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TPD52 gene:
    Search GeneIP for patents involving TPD52

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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