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TPCN2 Gene

protein-coding   GIFtS: 56
GCID: GC11P068816

Two Pore Segment Channel 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Two Pore Segment Channel 21 2
TPC22 3 5
Voltage-Dependent Calcium Channel Protein TPC22 3
SHEP102 5
Two Pore Calcium Channel Protein 22
Two-Pore Calcium Channel Protein 22

External Ids:    HGNC: 208201   Entrez Gene: 2199312   Ensembl: ENSG000001623417   OMIM: 6121635   UniProtKB: Q8NHX93   

Export aliases for TPCN2 gene to outside databases

Previous GC identifers: GC11P069066 GC11P068591 GC11P068572 GC11P065155


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TPCN2 Gene:
This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The
protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP)
-induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated
expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus
brown hair pigmentation.(provided by RefSeq, Dec 2009)

GeneCards Summary for TPCN2 Gene:
TPCN2 (two pore segment channel 2) is a protein-coding gene. GO annotations related to this gene include voltage-gated calcium channel activity and identical protein binding. An important paralog of this gene is TPCN1.

UniProtKB/Swiss-Prot: TPC2_HUMAN, Q8NHX9
Function: Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major
voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction

Gene Wiki entry for TPCN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TPCN2 gene promoter:
         MAZR   AML1a   CUTL1   NF-kappaB   Arnt   Roaz   Ik-2   NF-kappaB1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTPCN2 promoter sequence
   Search Chromatin IP Primers for TPCN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPCN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.3   Ensembl cytogenetic band:  11q13.3   HGNC cytogenetic band: 11q13.1

TPCN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPCN2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P068816:  view genomic region     (about GC identifiers)

Start:
68,816,350 bp from pter      End:
68,858,072 bp from pter
Size:
41,723 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TPC2_HUMAN, Q8NHX9 (See protein sequence)
Recommended Name: Two pore calcium channel protein 2  
Size: 752 amino acids; 85243 Da
Subunit: Homodimer (By similarity). Interacts with LRRK2
Secondary accessions: Q9NT82

Explore the universe of human proteins at neXtProt for TPCN2: NX_Q8NHX9

Explore proteomics data for TPCN2 at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • Glycosylation2 at Asn611, Asn618

  • See TPCN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_620714.2  
    ENSEMBL proteins: 
     ENSP00000294309   ENSP00000445551  
    Reactome Protein details: Q8NHX9

    TPCN2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TPCN: Voltage-gated ion channels / Two-pore channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: TPC2
    CatSper and Two-Pore channels

    3 InterPro protein domains:
     IPR027359 Channel_four-helix_dom
     IPR005821 Ion_trans_dom
     IPR028798 TPC2

    Graphical View of Domain Structure for InterPro Entry Q8NHX9

    ProtoNet protein and cluster: Q8NHX9

    UniProtKB/Swiss-Prot: TPC2_HUMAN, Q8NHX9
    Domain: Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and
    one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are
    characterized by a series of positively charged amino acids at every third position (By similarity)
    Similarity: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel
    subfamily


    Find genes that share domains with TPCN2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TPC2_HUMAN, Q8NHX9
    Function: Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major
    voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005245voltage-gated calcium channel activity ISS--
    GO:0005515protein binding IPI--
    GO:0019901protein kinase binding IPI--
    GO:0042802identical protein binding IPI--
         
    Find genes that share ontologies with TPCN2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TPCN2:
     Decreased Salmonella enterica  

         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tpcn2):
     behavior/neurological  endocrine/exocrine gland  hematopoietic system  immune system  integument 
     no phenotypic analysis  normal 

    Find genes that share phenotypes with TPCN2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TPCN2: Tpcn2tm1.1Dren Tpcn2tm1Lex

       genOway: Develop your customized and physiologically relevant rodent model for TPCN2

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    miRTarBase miRNAs that target TPCN2:
    hsa-mir-124-3p (MIRT022968)

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    hsa-miR-124 hsa-miR-593* hsa-miR-506 hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidTPCN2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TPC2_HUMAN, Q8NHX9: Lysosome membrane; Multi-pass membrane protein (By similarity). Note=Only the acidic
    lysosomal fraction is sensitive to NAADP (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    lysosome5
    vacuole5
    plasma membrane3
    endoplasmic reticulum2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome ----
    GO:0005765lysosomal membrane TAS--
    GO:0010008endosome membrane IDA19620632
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TPCN2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TPCN2 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    3Pancreatic secretion
    Pancreatic secretion


    Find genes that share SuperPaths with TPCN2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for TPCN2
        Stimuli-sensing channels


    1 Kegg Pathway  (Kegg details for TPCN2):
        Pancreatic secretion

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TPCN2
    Interactions:

        Search GeneGlobe Interaction Network for TPCN2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5 Interacting proteins for TPCN2 (Q8NHX91 ENSP000002943094) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TPCN1Q9ULQ11, ENSP000003763504EBI-5239949,EBI-5239895 STRING: ENSP00000376350
    HAX1O001651EBI-5239949,EBI-357001
    MTORP423451EBI-5239949,EBI-359260
    TPCN2Q8NHX91EBI-5239949,EBI-5239949
    MPPE1ENSP000003112004STRING: ENSP00000311200
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006874cellular calcium ion homeostasis IDA19387438
    GO:0006939smooth muscle contraction ISS--
    GO:0034220ion transmembrane transport TAS--
    GO:0051209release of sequestered calcium ion into cytosol IEA--

    Find genes that share ontologies with TPCN2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TPCN2 (TPC2)

    1 HMDB Compound for TPCN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TPCN2 gene: 
    NM_139075.3  

    Unigene Cluster for TPCN2:

    Two pore segment channel 2
    Hs.131851  [show with all ESTs]
    Unigene Representative Sequence: NM_139075
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000294309(uc009ysk.1 uc010rqg.1) ENST00000535009(uc001oor.2)
    ENST00000542467 ENST00000534832 ENST00000442692(uc001oos.2 uc021qmo.1)

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    SwitchGear 3'UTR luciferase reporter plasmidTPCN2 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat TPCN2

    Additional mRNA sequence: 

    AK023366.1 AK124882.1 AK298919.1 AL137479.1 AY029200.1 BC063008.1 BC064339.1 

    12 DOTS entries:

    DT.40232060  DT.100754345  DT.408015  DT.100754343  DT.97816364  DT.102830420  DT.95259567  DT.100714388 
    DT.121630714  DT.100734990  DT.102830419  DT.92060092 

    Selected AceView cDNA sequences (see all 115):

    BQ219203 AI636300 AI632451 AI695882 BQ186415 BF059396 BM747712 AI632290 
    AA574158 CD245584 BU681181 BF476556 CK300944 BQ017510 AI825151 BM728630 
    BI490867 AI695979 BQ639676 BI490907 AA309878 BG385902 AW845954 AU134158 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TPCN2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a ·
    SP1:                                -           -                                         -                                                                     
    SP2:                                                                                      -                             -     -     -                       -   
    SP3:                                -     -     -     -     -                             -                                                                     
    SP4:                                                                                                                                                            
    SP5:                                                                          -     -     -                                                                     

    ExUns: 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25a · 25b
    SP1:                          -                                       
    SP2:  -                 -     -                                       
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for TPCN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TPCN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTGAGGG
    TPCN2 Expression
    About this image


    TPCN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Cerebral Cortex
    TPCN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TPCN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.131851

    UniProtKB/Swiss-Prot: TPC2_HUMAN, Q8NHX9
    Tissue specificity: Widely expressed. Expressed at high level in liver and kidney

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPCN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TPCN2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tpcn21 , 5 two pore segment channel 21, 5 79.78(n)1
    75.31(a)1
      7 (89.02 cM)5
    2339791  NM_146206.41  NP_666318.21 
     1452539235 
    chicken
    (Gallus gallus)
    Aves TPCN21 two pore segment channel 2 68.54(n)
    68.26(a)
      423141  XM_004941528.1  XP_004941585.1 
    lizard
    (Anolis carolinensis)
    Reptilia TPCN26
    two pore segment channel 2
    68(a)
    1 ↔ 1
    1(55921632-55954432)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tpcn21 two pore segment channel 2 66.15(n)
    64.02(a)
      100492057  XM_002934070.2  XP_002934116.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tpcn21 two pore segment channel 2 61.14(n)
    58.91(a)
      777614  NM_001077722.1  NP_001071190.1 


    ENSEMBL Gene Tree for TPCN2 (if available)
    TreeFam Gene Tree for TPCN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TPCN2 gene
    TPCN12  

    Find genes that share paralogs with TPCN2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    TPC2_HUMAN, Q8NHX9: Genetic variants in TPCN2 define the skin/hair/eye pigmentation variation locus 10 (SHEP10)
    [MIM:612267]. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation,
    with a broad normal range that is subject to substantial geographic stratification. In the case of skin,
    individuals tend to have lighter pigmentation with increasing distance from the equator. By contrast, the
    majority of variation in human eye and hair color is found among individuals of European ancestry, with most
    other human populations fixed for brown eyes and black hair


    Selected SNPs for TPCN2 (see all 1442)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs352648751,2,,4
    C,Fpathogenic168846399(+) TGGAGA/TTGCTG 2 M L mis110Minor allele frequency- T:0.12NA NS EA EU 6491
    rs38292411,2,,4
    C,F,A,Hpathogenic168855363(+) GCCCGG/AGGAGG 2 /E /G mis127Minor allele frequency- A:0.24EA NA NS WA EU 9402
    rs1861425341,2
    --68814351(+) GTCTCA/GATCTA 1 -- us2k10--------
    rs1175629611,2
    F--68814431(+) ATTTGT/CAGGAC 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1123558501,2
    C--68814577(+) AAAGGG/TTGGAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1503583501,2
    C--68814860(+) CAACAA/C/GAACTG 1 -- us2k10--------
    rs107920101,2
    C--68814887(+) TTGGGG/TGCCCA 1 -- us2k18Minor allele frequency- T:0.38NA WA EA 368
    rs30186791,2
    C--68814894(-) TTTTTT/CGTGGG 1 -- us2k111Minor allele frequency- C:0.00NA WA CSA EA 373
    rs1909443351,2
    --68815027(+) GCTTAA/GTGATT 1 -- us2k10--------
    rs1823793121,2
    --68815061(+) CTTTCA/TCAGTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TPCN2 (68816350 - 68858072 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TPCN2 (see all 28):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2743408CNV Deletion23290073
    esv2744675CNV Deletion23290073
    esv2744672CNV Deletion23290073
    esv2741565CNV Deletion23290073
    esv2744676CNV Deletion23290073
    esv2744673CNV Deletion23290073
    esv998682CNV Deletion20482838
    esv2744678CNV Deletion23290073
    esv2744679CNV Deletion23290073
    esv1429725CNV Deletion17803354

    Human Gene Mutation Database (HGMD): TPCN2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TPCN2
    DNA2.0 Custom Variant and Variant Library Synthesis for TPCN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612163   
    OMIM disorders: 612267  

    Find genes that share disorders with TPCN2           About GenesLikeMe

    Genetic Association Database (GAD): TPCN2
    Human Genome Epidemiology (HuGE) Navigator: TPCN2 (1 document)

    Export disorders for TPCN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TPCN2 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with TPCN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two newly identified genetic determinants of pigmentation in Europeans. (PubMed id 18488028)1, 2, 4 Sulem P.... Stefansson K. (Nat. Genet. 2008)
    2. Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling. (PubMed id 19620632)1, 2, 9 Brailoiu E.... Patel S. (J. Cell Biol. 2009)
    3. Web-based, participant-driven studies yield novel genetic associations for common traits. (PubMed id 20585627)1, 4 Eriksson N....Mountain J. (PLoS Genet. 2010)
    4. NAADP mobilizes calcium from acidic organelles through two-pore channels. (PubMed id 19387438)1, 2 Calcraft P.J.... Zhu M.X. (Nature 2009)
    5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (Nature 2006)
    6. International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels. (PubMed id 16382101)1, 3 Clapham D.E. and Garbers D.L. (Pharmacol. Rev. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Leucine-rich repeat kinase 2 regulates autophagy through a calcium- dependent pathway involving NAADP. (PubMed id 22012985)2 Gomez-Suaga P.... Hilfiker S. (Hum. Mol. Genet. 2012)
    10. Two-pore channel 2 (TPC2) modulates store-operated Ca(2+) entry. (PubMed id 23077736)1 LA^pez J....Rosado J.A. (Biochim. Biophys. Acta 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 219931 HGNC: 20820 AceView: TPCN2 Ensembl:ENSG00000162341 euGenes: HUgn219931
    ECgene: TPCN2 Kegg: 219931 H-InvDB: TPCN2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TPCN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TPCN2 gene:
    Search GeneIP for patents involving TPCN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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