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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TPCN1 Gene

protein-coding   GIFtS: 53
GCID: GC12P113660

Two Pore Segment Channel 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Two Pore Segment Channel 11 2     Two Pore Calcium Channel Protein 12
TPC12 3 5     Two-Pore Channel 12
Voltage-Dependent Calcium Channel Protein TPC12 3     Two-Pore Segment Channel 12
KIAA11693 5     

External Ids:    HGNC: 181821   Entrez Gene: 533732   Ensembl: ENSG000001868157   OMIM: 6096665   UniProtKB: Q9ULQ13   

Export aliases for TPCN1 gene to outside databases

Previous GC identifers: GC12P113441 GC12P112071 GC12P112121 GC12P110671


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TPCN1 Gene:
Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to
S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000
(PubMed 10753632)).(supplied by OMIM, Mar 2008)

GeneCards Summary for TPCN1 Gene: 
TPCN1 (two pore segment channel 1) is a protein-coding gene. Diseases associated with TPCN1 include stomatitis, and thyroid cancer, and among its related super-pathways are Stimuli-sensing channels and SLC-mediated transmembrane transport. GO annotations related to this gene include NAADP-sensitive calcium-release channel activity and identical protein binding. An important paralog of this gene is TPCN2.

UniProtKB/Swiss-Prot: TPC1_HUMAN, Q9ULQ1
Function: Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major
voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane

Gene Wiki entry for TPCN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009775.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TPCN1 gene promoter:
         NF-YB   CBF-B   CBF-A   NF-YA   ARP-1   CP1C   CP1A   LUN-1   NF-Y   CBF-C   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTPCN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TPCN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPCN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.13   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.21

TPCN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPCN1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P113660:  view genomic region     (about GC identifiers)

Start:
113,658,855 bp from pter      End:
113,736,390 bp from pter
Size:
77,536 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TPC1_HUMAN, Q9ULQ1 (See protein sequence)
Recommended Name: Two pore calcium channel protein 1  
Size: 816 amino acids; 94147 Da
Subunit: Dimer (Potential)
Subcellular location: Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane
protein
Sequence caution: Sequence=AK057414; Type=Frameshift; Positions=273; Sequence=BAA86483.2; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: A7E258 Q86XS9 Q8NC20
Alternative splicing: 3 isoforms:  Q9ULQ1-1   Q9ULQ1-2   Q9ULQ1-3   

Explore the universe of human proteins at neXtProt for TPCN1: NX_Q9ULQ1

Explore proteomics data for TPCN1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9ULQ1

  • TPCN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TPCN1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001137291.1  NP_060371.2  

    ENSEMBL proteins: 
     ENSP00000447806   ENSP00000449560   ENSP00000447569   ENSP00000447073   ENSP00000447263  
     ENSP00000447181   ENSP00000335300   ENSP00000449944   ENSP00000448083   ENSP00000448704  
     ENSP00000376350   ENSP00000446767   ENSP00000448561   ENSP00000449564   ENSP00000448010  
     ENSP00000438125  
    Reactome Protein details: Q9ULQ1
    Human Recombinant Protein Products for TPCN1: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TPCN1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane TAS--
    GO:0010008endosome membrane IDA19620632
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    TPCN1 for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for TPCN1 

    Assay Products for TPCN1: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TPCN: Voltage-gated ion channels / Two-pore channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: TPC1 
    CatSper and Two-Pore channels

    2 InterPro protein domains:
     IPR027359 K_channel_four-helix_dom
     IPR005821 Ion_trans_dom

    Graphical View of Domain Structure for InterPro Entry Q9ULQ1

    ProtoNet protein and cluster: Q9ULQ1

    UniProtKB/Swiss-Prot: TPC1_HUMAN, Q9ULQ1
    Domain: Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and
    one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are
    characterized by a series of positively charged amino acids at every third position (By similarity)
    Similarity: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel
    subfamily


    TPCN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TPC1_HUMAN, Q9ULQ1
    Function: Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major
    voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005244voltage-gated ion channel activity IEA--
    GO:0005515protein binding IPI--
    GO:0042802identical protein binding IPI--
    GO:0072345NAADP-sensitive calcium-release channel activity IDA19620632
         
    TPCN1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tpcn1):
     immune system  no phenotypic analysis  normal 

    TPCN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tpcn1tm1.1Dren for TPCN1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TPCN1 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPCN1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TPCN1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.49
    Stimuli-sensing channels0.49
    2SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for TPCN1
        Transmembrane transport of small molecules
    Stimuli-sensing channels
    Ion channel transport



    TPCN1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TPCN1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for TPCN1 (Q9ULQ11 ENSP000003763504) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TPCN2Q8NHX91, ENSP000002943094EBI-5239895,EBI-5239949 STRING: ENSP00000294309
    TPCN1Q9ULQ11EBI-5239895,EBI-5239895
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0034220ion transmembrane transport TAS--
    GO:0055085transmembrane transport TAS--

    TPCN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TPCN1 (TPC1)

    1 HMDB Compound for TPCN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about TPCN1 / TPC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TPCN1 gene (2 alternative transcripts): 
    NM_001143819.1  NM_017901.4  

    Unigene Cluster for TPCN1:

    Two pore segment channel 1
    Hs.524763  [show with all ESTs]
    Unigene Representative Sequence: NM_001143819
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000552642 ENST00000547275 ENST00000552985 ENST00000550873 ENST00000551096
    ENST00000551099 ENST00000335509(uc001tuw.3 uc010syu.2) ENST00000552897
    ENST00000550785(uc001tux.3) ENST00000549279 ENST00000552077 ENST00000392569
    ENST00000552542 ENST00000428632(uc010syt.1) ENST00000548465 ENST00000546781
    ENST00000551127 ENST00000546503
    miRNA
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    Additional mRNA sequence: 

    AB032995.2 AK000619.1 AK025838.1 AK057414.1 AK093490.1 AK295022.1 AK296268.1 AY083666.1 
    BC007419.2 BC068001.1 BC069234.1 BC110885.1 BC136795.1 BC136796.1 BC150203.1 BC152423.1 

    16 DOTS entries:

    DT.95283828  DT.216244  DT.100816008  DT.95215830  DT.91920798  DT.121170051  DT.92003407  DT.92439571 
    DT.121169983  DT.40311973  DT.92439573  DT.95100794  DT.95303166  DT.101960618  DT.40259869  DT.99949916 

    24/335 AceView cDNA sequences (see all 335):

    AI017512 CR614337 AI564395 H50290 AI591208 BM670458 BG756072 AL550149 
    CB119608 AI198038 CA449066 BU146988 BF590010 R88552 BM827150 AW243558 
    AW589639 AI223360 BE559995 AL134927 BX283980 BU194218 BQ679647 BF087651 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TPCN1 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
    SP1:                                                                                                                                            -               
    SP2:        -     -     -                 -                                                                                                                     
    SP3:                          -           -                                                                                                                     
    SP4:                                      -                                                                                                                     
    SP5:                    -     -                                                                                                                                 

    ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
    SP1:        -                       -         
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for TPCN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TPCN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGACAATCA
    TPCN1 Expression
    About this image


    See TPCN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TPCN1

    SOURCE GeneReport for Unigene cluster: Hs.524763

    UniProtKB/Swiss-Prot: TPC1_HUMAN, Q9ULQ1
    Tissue specificity: Highest expression found in the heart and kidney, and lowest expression found in the spleen

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPCN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TPCN1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tpcn11 , 5 two pore channel 11, 5 86.68(n)1
    91.05(a)1
      5 (60.63 cM)5
    2529721  NM_145853.21  NP_665852.11 
     1205341605 
    chicken
    (Gallus gallus)
    Aves TPCN11 two pore segment channel 1 75.69(n)
    82.41(a)
      417033  XM_415322.3  XP_415322.2 
    lizard
    (Anolis carolinensis)
    Reptilia TPCN16
    two pore segment channel 1
    79(a)
    1 ↔ 1
    GL343338.1(823523-843752)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5675341 calcium channel, voltage-dependent, N type, alpha 1B more 69.38(n)
    74.02(a)
      567534  XM_690831.4  XP_695923.3 


    ENSEMBL Gene Tree for TPCN1 (if available)
    TreeFam Gene Tree for TPCN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TPCN1 gene
    TPCN22  
    15 SIMAP similar genes for TPCN1 using alignment to 14 protein entries:     TPC1_HUMAN (see all proteins):
    SCN9A    SCN4A    SCN5A    CACNA1H    SCN11A    SCN8A
    SCN3A    CACNA1F    SCN1A    SCN2A    SCN2A2    SCN7A
    CACNA1B    CACNA1E    CACNA1A

    TPCN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1488 SNPs in TPCN1 are shown (see all 1488)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438650641,2
    Cuntested1113705738(+) TCATCC/TGGCAC 4 R W mis10--------
    rs1163995061,2
    C,F--113660892(+) CTCTTC/TTGCCT 2 -- int11Minor allele frequency- T:0.14WA 118
    rs1826060411,2
    --113660970(+) CACAGG/TAAGTG 2 -- int10--------
    rs619435801,2
    C--113660993(+) AGCTAC/TGGGCT 2 -- int13Minor allele frequency- T:0.09NA EA 242
    rs1876625351,2
    --113661028(+) CTTTCG/TCTGCC 2 -- int10--------
    rs764019931,2
    C--113661146(+) AGTTGG/AGAGGC 2 -- int12Minor allele frequency- A:0.04WA 120
    rs731928111,2
    C--113661258(+) TTTTTG/TGTTCT 2 -- int10--------
    rs1916579311,2
    --113661388(+) CTGTCA/GCCCAG 2 -- int10--------
    rs1843010341,2
    --113661471(+) AGGCTC/TCCCAG 2 -- int10--------
    rs38901451,2
    C,F--113661629(+) caggcC/Atgagc 2 -- int13Minor allele frequency- A:0.50WA CSA 6

    HapMap Linkage Disequilibrium report for TPCN1 (113658855 - 113736390 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TPCN1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2226471CNV Deletion18987734
    esv2746378CNV Deletion23290073
    nsv899527CNV Loss21882294
    nsv899528CNV Loss21882294
    esv6807CNV Loss19470904
    nsv899530CNV Gain21882294
    nsv519540CNV Gain+Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609666    OMIM disorders: --

    3 diseases for TPCN1:    About MalaCards
    stomatitis    thyroid cancer    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for TPCN1:
    Thyroid cancer

    TPCN1 for disorders           About GeneDecksing


    Export disorders for TPCN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TPCN1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with TPCN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2, 3 Hirosawa M.... Ohara O. (1999)
    2. Essential requirement for two-pore channel 1 in NAADP -mediated calcium signaling. (PubMed id 19620632)1, 2, 9 Brailoiu E....Patel S. (2009)
    3. NAADP mobilizes calcium from acidic organelles throug h two-pore channels. (PubMed id 19387438)1, 2 Calcraft P.J....Zhu M.X. (2009)
    4. International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels. (PubMed id 16382101)1, 3 Clapham D.E. and Garbers D.L. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    7. Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels. (PubMed id 10753632)1, 3 Ishibashi K....Imai M. (2000)
    8. Regulation of a proteinaceous elicitor-induced Ca2+ in flux and production of phytoalexins by a putative voltage-gated cation channel, OsTPC1, in cultured rice cells. (PubMed id 22270358)1 Hamada H....Kuchitsu K. (2012)
    9. Preliminary evidence of genetic determinants of adipon ectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet N etwork. (PubMed id 23149075)1 Aslibekyan S....Arnett D.K. (2012)
    10. Membrane potential regulates nicotinic acid adenine di nucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1. (PubMed id 22500018)1 Rybalchenko V....Muallem S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 53373 HGNC: 18182 AceView: TPCN1 Ensembl:ENSG00000186815 euGenes: HUgn53373
    ECgene: TPCN1 H-InvDB: TPCN1

    (According to HUGE)
    About This Section
    HUGE: KIAA1169

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TPCN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TPCN1 gene:
    Search GeneIP for patents involving TPCN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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