Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TPCN1 Gene

Aliases for TPCN1 Gene

  • Two Pore Segment Channel 1 2 3
  • TPC1 3 4 6
  • Voltage-Dependent Calcium Channel Protein TPC1 3 4
  • KIAA1169 4 6
  • Two Pore Calcium Channel Protein 1 3
  • Two-Pore Segment Channel 1 3
  • Two-Pore Channel 1 3

External Ids for TPCN1 Gene

Previous GeneCards Identifiers for TPCN1 Gene

  • GC12P113441
  • GC12P112071
  • GC12P112121
  • GC12P113660
  • GC12P110671

Summaries for TPCN1 Gene

Entrez Gene Summary for TPCN1 Gene

  • Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TPCN1 Gene

TPCN1 (Two Pore Segment Channel 1) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include identical protein binding and NAADP-sensitive calcium-release channel activity. An important paralog of this gene is TPCN2.

UniProtKB/Swiss-Prot for TPCN1 Gene

  • Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane.

Gene Wiki entry for TPCN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPCN1 Gene

Genomics for TPCN1 Gene

Regulatory Elements for TPCN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TPCN1 Gene

113,221,050 bp from pter
113,298,585 bp from pter
77,536 bases
Plus strand

Genomic View for TPCN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPCN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPCN1 Gene

Proteins for TPCN1 Gene

  • Protein details for TPCN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Two pore calcium channel protein 1
    Protein Accession:
    Secondary Accessions:
    • A7E258
    • Q86XS9
    • Q8NC20

    Protein attributes for TPCN1 Gene

    816 amino acids
    Molecular mass:
    94147 Da
    Quaternary structure:
    • Dimer.
    • Sequence=AK057414; Type=Frameshift; Positions=273; Evidence={ECO:0000305}; Sequence=BAA86483.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TPCN1 Gene


neXtProt entry for TPCN1 Gene

Proteomics data for TPCN1 Gene at MOPED

Post-translational modifications for TPCN1 Gene

  • Glycosylation at Asn599, Asn611, and Asn616
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TPCN1 Gene

Domains for TPCN1 Gene

Gene Families for TPCN1 Gene

  • TPCN :Voltage-gated ion channels / Two-pore channels

Protein Domains for TPCN1 Gene

Suggested Antigen Peptide Sequences for TPCN1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9ULQ1
  • Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position (By similarity).
  • Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily.
genes like me logo Genes that share domains with TPCN1: view

Function for TPCN1 Gene

Molecular function for TPCN1 Gene

UniProtKB/Swiss-Prot Function:
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane.

Gene Ontology (GO) - Molecular Function for TPCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005245 voltage-gated calcium channel activity IBA --
GO:0005515 protein binding IPI 21903581
GO:0042802 identical protein binding IPI 21903581
GO:0072345 NAADP-sensitive calcium-release channel activity IDA 19620632
genes like me logo Genes that share ontologies with TPCN1: view
genes like me logo Genes that share phenotypes with TPCN1: view

Animal Models for TPCN1 Gene

MGI Knock Outs for TPCN1:

Animal Model Products

miRNA for TPCN1 Gene

miRTarBase miRNAs that target TPCN1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPCN1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TPCN1 Gene

Localization for TPCN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPCN1 Gene

Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TPCN1 Gene COMPARTMENTS Subcellular localization image for TPCN1 gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
plasma membrane 3
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TPCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane TAS --
GO:0005886 plasma membrane IBA --
GO:0010008 endosome membrane IDA 19620632
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TPCN1: view

Pathways for TPCN1 Gene

genes like me logo Genes that share pathways with TPCN1: view

Pathways by source for TPCN1 Gene

Interacting Proteins for TPCN1 Gene

Gene Ontology (GO) - Biological Process for TPCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006816 calcium ion transport IBA --
GO:0034220 ion transmembrane transport TAS --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with TPCN1: view

Compounds for TPCN1 Gene

(1) HMDB Compounds for TPCN1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with TPCN1: view

Transcripts for TPCN1 Gene

Unigene Clusters for TPCN1 Gene

Two pore segment channel 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPCN1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPCN1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1: -
SP2: - - - -
SP3: - -
SP4: -
SP5: - -
SP6: - - -

ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1: - -
SP7: -

Relevant External Links for TPCN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPCN1 Gene

mRNA expression in normal human tissues for TPCN1 Gene

Protein differential expression in normal tissues for TPCN1 Gene

This gene is overexpressed in Plasma (36.6) and Heart (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPCN1 Gene

SOURCE GeneReport for Unigene cluster for TPCN1 Gene Hs.524763

mRNA Expression by UniProt/SwissProt for TPCN1 Gene

Tissue specificity: Highest expression found in the heart and kidney, and lowest expression found in the spleen.
genes like me logo Genes that share expressions with TPCN1: view

Expression partners for TPCN1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TPCN1 Gene

Orthologs for TPCN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TPCN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TPCN1 35
  • 90.14 (n)
  • 92.27 (a)
TPCN1 36
  • 90 (a)
(Canis familiaris)
Mammalia TPCN1 35
  • 90.4 (n)
  • 93.63 (a)
TPCN1 36
  • 92 (a)
(Mus musculus)
Mammalia Tpcn1 35
  • 86.68 (n)
  • 90.93 (a)
Tpcn1 16
Tpcn1 36
  • 91 (a)
(Pan troglodytes)
Mammalia TPCN1 35
  • 99.4 (n)
  • 99.77 (a)
TPCN1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tpcn1 35
  • 86.6 (n)
  • 89.95 (a)
(Monodelphis domestica)
Mammalia TPCN1 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia TPCN1 36
  • 75 (a)
(Gallus gallus)
Aves TPCN1 35
  • 75.1 (n)
  • 81.82 (a)
TPCN1 36
  • 82 (a)
(Anolis carolinensis)
Reptilia TPCN1 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tpcn1 35
  • 66.83 (n)
  • 72.65 (a)
(Danio rerio)
Actinopterygii tpcn1 35
  • 69.03 (n)
  • 73.26 (a)
tpcn1 36
  • 71 (a)
Species with no ortholog for TPCN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TPCN1 Gene

Gene Tree for TPCN1 (if available)
Gene Tree for TPCN1 (if available)

Paralogs for TPCN1 Gene

Paralogs for TPCN1 Gene

genes like me logo Genes that share paralogs with TPCN1: view

Variants for TPCN1 Gene

Sequence variations from dbSNP and Humsavar for TPCN1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs729062 -- 113,250,054(-) AACAC(C/T)TGCGG intron-variant
rs1046787 -- 113,297,358(+) AGGGT(C/G)CGAAG utr-variant-3-prime
rs1051330 -- 113,235,494(+) TTTTT(A/T)AAAGT intron-variant
rs1060658 -- 113,262,232(+) atggc(A/G)gaacc intron-variant
rs1458366 -- 113,234,772(-) AATAA(A/G)TCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPCN1 Gene

Variant ID Type Subtype PubMed ID
nsv519540 CNV Gain+Loss 19592680
nsv899527 CNV Loss 21882294
nsv899528 CNV Loss 21882294
nsv899530 CNV Gain 21882294
esv2226471 CNV Deletion 18987734
esv2746378 CNV Deletion 23290073
esv6807 CNV Loss 19470904

Relevant External Links for TPCN1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPCN1 Gene

Disorders for TPCN1 Gene

(1) University of Copenhagen DISEASES for TPCN1 Gene

genes like me logo Genes that share disorders with TPCN1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for TPCN1 Gene

Publications for TPCN1 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling. (PMID: 19620632) Brailoiu E. … Patel S. (J. Cell Biol. 2009) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels. (PMID: 10753632) Ishibashi K. … Imai M. (Biochem. Biophys. Res. Commun. 2000) 2 3
  5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4

Products for TPCN1 Gene

Sources for TPCN1 Gene

Back to Top