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Aliases for TPBGL Gene

Subcategory (RNA class) for TPBGL Gene


Aliases for TPBGL Gene

  • Trophoblast Glycoprotein-Like 2 3 5

External Ids for TPBGL Gene

ORGUL Members for TPBGL Gene

Previous GeneCards Identifiers for TPBGL Gene

  • GC11P074954
  • GC11P074990

Summaries for TPBGL Gene

GeneCards Summary for TPBGL Gene

TPBGL (Trophoblast Glycoprotein-Like) is a Protein Coding gene, and is affiliated with the lncRNA class. An important paralog of this gene is TPBG.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPBGL Gene

Genomics for TPBGL Gene

Regulatory Elements for TPBGL Gene

Enhancers for TPBGL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TPBGL on UCSC Golden Path with GeneCards custom track

Promoters for TPBGL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TPBGL Gene

75,240,905 bp from pter
75,243,704 bp from pter
2,800 bases
Plus strand

Genomic View for TPBGL Gene

Genes around TPBGL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPBGL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPBGL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPBGL Gene

Proteins for TPBGL Gene

  • Protein details for TPBGL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trophoblast glycoprotein-like
    Protein Accession:

    Protein attributes for TPBGL Gene

    382 amino acids
    Molecular mass:
    40400 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TPBGL Gene

Post-translational modifications for TPBGL Gene

Other Protein References for TPBGL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TPBGL Gene

Domains & Families for TPBGL Gene

Protein Domains for TPBGL Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 LRR (leucine-rich) repeats.
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with TPBGL: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TPBGL Gene

Function for TPBGL Gene

Gene Ontology (GO) - Molecular Function for TPBGL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008201 heparin binding IBA --
GO:0048495 Roundabout binding IBA --
genes like me logo Genes that share ontologies with TPBGL: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TPBGL Gene

Localization for TPBGL Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPBGL Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for TPBGL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0005615 extracellular space IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TPBGL: view

No data available for Subcellular locations from COMPARTMENTS for TPBGL Gene

Pathways & Interactions for TPBGL Gene

SuperPathways for TPBGL Gene

No Data Available

Interacting Proteins for TPBGL Gene

Gene Ontology (GO) - Biological Process for TPBGL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035385 Roundabout signaling pathway IBA --
GO:0048846 axon extension involved in axon guidance IBA --
GO:0050770 regulation of axonogenesis IBA --
genes like me logo Genes that share ontologies with TPBGL: view

No data available for Pathways by source and SIGNOR curated interactions for TPBGL Gene

Drugs & Compounds for TPBGL Gene

No Compound Related Data Available

Transcripts for TPBGL Gene

mRNA/cDNA for TPBGL Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TPBGL Gene

Trophoblast glycoprotein-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPBGL Gene

No ASD Table

Relevant External Links for TPBGL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPBGL Gene

NURSA nuclear receptor signaling pathways regulating expression of TPBGL Gene:


SOURCE GeneReport for Unigene cluster for TPBGL Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TPBGL Gene

Orthologs for TPBGL Gene

This gene was present in the common ancestor of chordates.

Orthologs for TPBGL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TPBGL 34
  • 90.14 (n)
  • 90.05 (a)
  • 92 (a)
(Canis familiaris)
Mammalia TPBGL 34
  • 93.28 (n)
  • 91.71 (a)
  • 91 (a)
(Mus musculus)
Mammalia Gm4980 34
  • 85.44 (n)
  • 86.84 (a)
Tpbgl 16
Gm4980 35
  • 82 (a)
(Pan troglodytes)
Mammalia TPBGL 34
  • 99.56 (n)
  • 99.74 (a)
(Rattus norvegicus)
Mammalia Tpbgl 34
  • 86.05 (n)
  • 87.37 (a)
(Monodelphis domestica)
Mammalia TPBGL 35
  • 60 (a)
(Gallus gallus)
Aves TPBGL 35
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 34 (a)
(Danio rerio)
Actinopterygii waif2 34
  • 47.6 (n)
  • 42.47 (a)
waif2 35
  • 40 (a)
Species where no ortholog for TPBGL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TPBGL Gene

Gene Tree for TPBGL (if available)
Gene Tree for TPBGL (if available)

Paralogs for TPBGL Gene

Paralogs for TPBGL Gene

(1) SIMAP similar genes for TPBGL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TPBGL: view

Variants for TPBGL Gene

Sequence variations from dbSNP and Humsavar for TPBGL Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7943934 -- 75,239,302(+) AGTGT(A/G)CATAT upstream-variant-2KB
rs34103907 -- 75,243,020(+) CTTGA(-/C)CCCCC utr-variant-3-prime
rs77276998 -- 75,240,575(+) AACCA(A/G)GTCGG upstream-variant-2KB
rs77581800 -- 75,243,240(+) TAGTG(C/G)GGCAT utr-variant-3-prime
rs35688933 -- 75,242,278(+) CTGAG(-/T)ACCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TPBGL Gene

Variant ID Type Subtype PubMed ID
dgv1225n100 CNV gain 25217958
esv3626851 CNV gain 21293372
nsv1070052 CNV deletion 25765185
nsv1143548 CNV deletion 24896259
nsv832211 CNV loss 17160897

Variation tolerance for TPBGL Gene

Gene Damage Index Score: 2.43; 42.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPBGL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPBGL Gene

Disorders for TPBGL Gene

Relevant External Links for TPBGL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TPBGL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPBGL Gene

Publications for TPBGL Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 65
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for TPBGL Gene

Sources for TPBGL Gene

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