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TPBG Gene

protein-coding   GIFtS: 56
GCID: GC06P083072

Trophoblast Glycoprotein

  See TPBG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Trophoblast Glycoprotein1 2     5T4 Oncotrophoblast Glycoprotein2 3
5T42 3     M6P12 3
5T4 Oncofetal Antigen2 3     5T4AG2
5T4 Oncofetal Trophoblast Glycoprotein2 3     

External Ids:    HGNC: 120041   Entrez Gene: 71622   Ensembl: ENSG000001462427   OMIM: 1909205   UniProtKB: Q136413   

Export aliases for TPBG gene to outside databases

Previous GC identifers: GC06P083027 GC06P083069 GC06P083130 GC06P080300


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TPBG Gene:
This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded
protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed
in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the
5' UTR results in multiple transcript variants that encode the same protein. (provided by RefSeq, Oct 2009)

GeneCards Summary for TPBG Gene:
TPBG (trophoblast glycoprotein) is a protein-coding gene. Diseases associated with TPBG include malignant pleural mesothelioma, and vaccinia. An important paralog of this gene is TPBGL.

Gene Wiki entry for TPBG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TPBG gene promoter:
         ER-alpha   STAT5B   Pax-5   p53   FOXD1   CUTL1   YY1   CREB   deltaCREB   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTPBG promoter sequence
   Search Chromatin IP Primers for TPBG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPBG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14-q15   Ensembl cytogenetic band:  6q14.1   HGNC cytogenetic band: 6q14-q15

TPBG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPBG gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P083072:  view genomic region     (about GC identifiers)

Start:
83,072,923 bp from pter      End:
83,080,545 bp from pter
Size:
7,623 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TPBG_HUMAN, Q13641 (See protein sequence)
Recommended Name: Trophoblast glycoprotein precursor  
Size: 420 amino acids; 46032 Da
Miscellaneous: Antigen 5T4 is overexpressed by a wide spectrum of cancers, including colorectal, ovarian and
gastric, but with a limited normal tissue expression. Could be used for tumor immunotherapy

Explore the universe of human proteins at neXtProt for TPBG: NX_Q13641

Explore proteomics data for TPBG at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn81, Asn124, Asn275
  • Modification sites at PhosphoSitePlus

  • See TPBG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001159864.1  NP_006661.1  

    ENSEMBL proteins: 
     ENSP00000358765   ENSP00000441219   ENSP00000440049  

    TPBG Human Recombinant Protein Products:

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    Novus Biologicals TPBG Proteins
    Novus Biologicals TPBG Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TPBG

     
    Search eBioscience for Proteins for TPBG 

    TPBG Antibody Products:

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    Cloud-Clone Corp. Antibodies for TPBG
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    LSBio Antibodies in human, mouse, rat for TPBG

    TPBG Assay Products:

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    Cloud-Clone Corp. ELISAs for TPBG
    Cloud-Clone Corp. CLIAs for TPBG
    Search eBioscience for ELISAs for TPBG 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000483 Cys-rich_flank_reg_C
     IPR000372 LRR-contain_N
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp

    Graphical View of Domain Structure for InterPro Entry Q13641

    ProtoNet protein and cluster: Q13641

    3 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: TPBG_HUMAN, Q13641
    Similarity: Contains 6 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    Find genes that share domains with TPBG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for TPBG:
    trophoblast glycoprotein

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TPBG           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tpbg):
     cellular  mortality/aging  nervous system 

    Find genes that share phenotypes with TPBG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tpbgtm1Lex for TPBG

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TPBG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TPBG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TPBG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TPBG

    miRNA
    Products:
        
    miRTarBase miRNAs that target TPBG:
    hsa-mir-505-3p (MIRT041063), hsa-mir-16-5p (MIRT031878), hsa-mir-30a-5p (MIRT028555), hsa-let-7b-5p (MIRT032386), hsa-mir-155-5p (MIRT020868)

    Block miRNA regulation of human, mouse, rat TPBG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TPBG (see all 26):
    hsa-miR-320a hsa-miR-34b* hsa-miR-548v hsa-miR-1205 hsa-miR-221 hsa-miR-548a-3p hsa-miR-1304 hsa-miR-548g
    SwitchGear 3'UTR luciferase reporter plasmidTPBG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TPBG
    Predesigned siRNA for gene silencing in human, mouse, rat TPBG

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): TPBG (NM_006670)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TPBG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPBG

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TPBG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPBG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TPBG_HUMAN, Q13641: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum2
    mitochondrion2
    cytoskeleton1
    cytosol1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum IEA--
    GO:0005887integral component of plasma membrane TAS10366710

    Find genes that share ontologies with TPBG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including TPBG: 
              Parkinson's Disease in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TPBG

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TPBG (Q136412, 3 ENSP000003587654) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GIPC1O149082, 3, ENSP000003406984MINT-62472 MINT-62471 MINT-62470 I2D: score=3 STRING: ENSP00000340698
    CAB39ENSP000002584184STRING: ENSP00000258418
    CAB39LENSP000002616694STRING: ENSP00000261669
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion NAS10366710

    Find genes that share ontologies with TPBG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TPBG

    1 Novoseek inferred chemical compound relationship for TPBG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trovax 98.2 4 16630022 (1), 19342962 (1), 16740766 (1), 18567615 (1)



    Find genes that share compounds with TPBG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TPBG gene (2 alternative transcripts): 
    NM_001166392.1  NM_006670.4  

    Unigene Cluster for TPBG:

    Trophoblast glycoprotein
    Hs.82128  [show with all ESTs]
    Unigene Representative Sequence: NM_006670
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369750 ENST00000535040(uc003pjn.4) ENST00000543496(uc003pjo.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TPBG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TPBG (see all 26):
    hsa-miR-320a hsa-miR-34b* hsa-miR-548v hsa-miR-1205 hsa-miR-221 hsa-miR-548a-3p hsa-miR-1304 hsa-miR-548g
    SwitchGear 3'UTR luciferase reporter plasmidTPBG 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TPBG
    Predesigned siRNA for gene silencing in human, mouse, rat TPBG
    Clone
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    OriGene clones in human, mouse for TPBG (see all 12)
    OriGene ORF clones in mouse, rat for TPBG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TPBG (NM_006670)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TPBG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPBG
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TPBG
    OriGene qSTAR qPCR primer pairs in human, mouse for TPBG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TPBG
      QuantiTect SYBR Green Assays in human, mouse, rat TPBG
      QuantiFast Probe-based Assays in human, mouse, rat TPBG

    Additional mRNA sequence: 

    AK074786.1 AK074790.1 AK291170.1 BC037161.2 Z29083.1 

    7 DOTS entries:

    DT.100652597  DT.214958  DT.91651841  DT.92008525  DT.95222154  DT.97843180  DT.102832548 

    Selected AceView cDNA sequences (see all 181):

    AK074790 AA235339 BM557922 N22591 BQ272253 BF970819 AI474247 N76098 
    AA425666 BU684399 AA417953 AA299403 AI342491 AI080659 CB242827 AI609599 
    BM699335 AI350569 AI857997 AI004700 AA603684 AA385052 BF477755 CA413562 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TPBG    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d
    SP1:                          -                 -                                 
    SP2:                          -           -     -     -                           
    SP3:                          -                 -     -     -                     
    SP4:                          -                                                   
    SP5:                                                                              


    ECgene alternative splicing isoforms for TPBG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TPBG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTACATTTT
    TPBG Expression
    About this image


    TPBG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Thalamus
             N2/LSB/S/F8/CHIR-induced cells
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Mesencephalic Floor Plate
     
     Neurons
             Midbrain dopaminergic-like neurons
    TPBG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TPBG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.82128

    UniProtKB/Swiss-Prot: TPBG_HUMAN, Q13641
    Tissue specificity: Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for
    trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few
    epithelial cell types but is found on a variety of carcinoma

        Pathway & Disease-focused RT2 Profiler PCR Array including TPBG: 
              Parkinson's Disease in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TPBG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPBG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TPBG gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tpbg1 , 5 trophoblast glycoprotein1, 5 82.86(n)1
    82.62(a)1
      9 (46.40 cM)5
    219831  NM_011627.41  NP_035757.21 
     858423805 
    chicken
    (Gallus gallus)
    Aves TPBG1 trophoblast glycoprotein 69.14(n)
    68.38(a)
      772098  XM_001235285.3  XP_001235286.2 
    lizard
    (Anolis carolinensis)
    Reptilia TPBG6
    trophoblast glycoprotein
    94(a)
    1 ↔ 1
    1(198107947-198108111)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.55482 Xenopus laevis transcribed sequence with moderate similarity more 78.76(n)    48030760 
    zebrafish
    (Danio rerio)
    Actinopterygii tpbgb1 trophoblast glycoprotein b 52.7(n)
    49.26(a)
      792712  NM_001252462.1  NP_001239391.1 


    ENSEMBL Gene Tree for TPBG (if available)
    TreeFam Gene Tree for TPBG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TPBG gene
    TPBGL2  

    Find genes that share paralogs with TPBG           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TPBG
    PGOHUM00000258595


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TPBG (see all 163)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1892950361,2
    --83071121(+) TATTTA/TTCCTT 1 -- us2k10--------
    rs1816076131,2
    --83071159(+) AGATAG/TAGTGG 1 -- us2k10--------
    rs1450325081,2
    C--83071200(+) TAGGAA/GAGAAC 1 -- us2k10--------
    rs624313191,2
    C,F--83071334(+) AATGAT/CCCTAA 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1447246521,2
    C--83071414(+) AAAGGA/GAACAA 1 -- us2k10--------
    rs1851676481,2
    --83071524(+) GGCAGA/GCAAAT 1 -- us2k10--------
    rs1896395951,2
    --83071637(+) GAGTAC/TCGAAG 1 -- us2k10--------
    rs1815289121,2
    --83071696(+) TGGAAA/GACACT 1 -- us2k10--------
    rs1387629281,2
    --83071976(+) ATCATA/GCAGTA 2 -- us2k10--------
    rs1863405821,2
    --83072047(+) AACCAA/CCACCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TPBG (83072923 - 83080545 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TPBG:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7937CNV Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TPBG
    DNA2.0 Custom Variant and Variant Library Synthesis for TPBG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 190920    OMIM disorders: --

    2 diseases for TPBG:    
    About MalaCards
    malignant pleural mesothelioma    vaccinia


    Find genes that share disorders with TPBG           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TPBG gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma 47.8 14 7593330 (3), 16630022 (2), 18097562 (1), 8132670 (1) (see all 11)
    carcinoma renal cell 44.3 5 16222313 (3), 18004564 (1)
    melanoma b16 41.8 2 16758205 (1)
    colorectal cancer 40.8 7 18833005 (3), 8180020 (2), 16630022 (1), 18567615 (1)
    metastasis 40.4 6 8132670 (1), 12168897 (1), 9815581 (1), 9855063 (1) (see all 6)
    gastric carcinoma 36 8 9855063 (5), 1419629 (2), 16646078 (1)
    colorectal carcinoma 33.2 4 9815581 (3), 8180020 (1)
    tumors 29.4 15 16646078 (3), 12481437 (2), 16311730 (2), 9815581 (2) (see all 7)
    cancer 29.2 15 11708475 (3), 12481437 (2), 12003637 (2), 16222313 (1) (see all 10)
    cancer lung 24.4 3 11708475 (2), 11437414 (1)

    Genetic Association Database (GAD): TPBG

    Export disorders for TPBG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TPBG gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with TPBG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a cDNA encoding 5T4 oncofetal trophoblast glycoprotein: an antigen associated with metastasis contains leucine rich repeats. (PubMed id 8132670)1, 2, 3, 9 Myers K.A....Stern P.L. (J. Biol. Chem. 1994)
    2. Attenuated recombinant vaccinia virus expressing oncofetal antigen (tumor-associated antigen) 5T4 induces active therapy of established tumors. (PubMed id 12481437)1, 2, 9 Mulryan K.... Carroll M.W. (Mol. Cancer Ther. 2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. CD8 T-cell recognition of human 5T4 oncofetal antigen. (PubMed id 16646078)1, 9 Smyth L.J....Stern P.L. (Int. J. Cancer 2006)
    6. Metastasis-associated 5T4 antigen disrupts cell-cell contacts and induces cellular motility in epithelial cells. (PubMed id 8895545)1, 9 Carsberg C.J....Stern P.L. (Int. J. Cancer 1996)
    7. Metastasis-associated 5T4 oncofoetal antigen is concentrated at microvillus projections of the plasma membrane. (PubMed id 7593330)1, 9 Carsberg C.J....Stern P.L. (J. Cell. Sci. 1995)
    8. Cell surface 5T4 antigen is transiently upregulated during early human embryonic stem cell differentiation: effect of 5T4 phenotype on neural lineage formation. (PubMed id 16616918)1, 9 Ward C.M....Stern P.L. (Exp. Cell Res. 2006)
    9. An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases. (PubMed id 18833005)1, 9 Elkord E....Stern P.L. (J. Immunother. 2008)
    10. Organisation of the mouse and human 5T4 oncofoetal leucine-rich glycoprotein genes and expression in foetal and adult murine tissues. (PubMed id 10366710)1, 9 King K.W....Myers K.A. (Biochim. Biophys. Acta 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7162 HGNC: 12004 AceView: TPBG Ensembl:ENSG00000146242 euGenes: HUgn7162
    ECgene: TPBG H-InvDB: TPBG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TPBG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TPBG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TPBG gene:
    Search GeneIP for patents involving TPBG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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