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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TPBG Gene

protein-coding   GIFtS: 54
GCID: GC06P083072

trophoblast glycoprotein
 Explore 16 diseases affiliated with
TPBG via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TPBG    

Aliases
for TPBG gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Trophoblast Glycoprotein1 2     5T4 Oncotrophoblast Glycoprotein2 3
5T41 2 3     M6P12 3
5T4 Oncofetal Antigen2 3     5T4-AG1
5T4 Oncofetal Trophoblast Glycoprotein2 3     5T4AG2

External Ids:    HGNC: 120041   Entrez Gene: 71622   Ensembl: ENSG000001462427   OMIM: 1909205   UniProtKB: Q136413   

Export aliases for TPBG gene to outside databases

Previous GC identifers: GC06P083027 GC06P083069 GC06P083130 GC06P080300


Summaries
for TPBG gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TPBG:
This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein
is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many
tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results
in multiple transcript variants that encode the same protein. (provided by RefSeq, Oct 2009)

Gene Wiki entry for TPBG


Genomic Views
for TPBG gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007299.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TPBG gene promoter:
         ER-alpha   STAT5B   Pax-5   p53   FOXD1   CUTL1   YY1   CREB   deltaCREB   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TPBG promoter sequence
   Search SABiosciences Chromatin IP Primers for TPBG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPBG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14-q15   Ensembl cytogenetic band:  6q14.1   HGNC cytogenetic band: 6q14-q15

TPBG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPBG gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P083072:  view genomic region     (about GC identifiers)

Start:
 83,072,923 bp from pter      End:
 83,080,545 bp from pter
Size:
 7,623 bases      Orientation:
 plus strand

Proteins
for TPBG gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TPBG_HUMAN, Q13641 (See protein sequence)
Recommended Name: Trophoblast glycoprotein precursor  
Size: 420 amino acids; 46032 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Miscellaneous: Antigen 5T4 is overexpressed by a wide spectrum of cancers, including colorectal, ovarian and gastric,
but with a limited normal tissue expression. Could be used for tumor immunotherapy

Explore the universe of human proteins at neXtProt for TPBG: NX_Q13641

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13641

    • TPBG Protein expression data from MOPED and PaxDb:    About this image 
    TPBG Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001159864.1  NP_006661.1  

    ENSEMBL proteins: 
     ENSP00000358765   ENSP00000441219   ENSP00000440049  

    Human Recombinant Protein Products for TPBG: 
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    Novus Biologicals TPBG Proteins
    Novus Biologicals TPBG Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TPBG

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum IEA--
    GO:0005887integral to plasma membrane TAS10366710

    TPBG for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TPBG gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TPBG for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000483 Cys-rich_flank_reg_C
     IPR000372 LRR-contain_N
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp

    Graphical View of Domain Structure for InterPro Entry Q13641

    ProtoNet protein and cluster: Q13641

    3 Blocks protein families:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: TPBG_HUMAN, Q13641
    Similarity: Contains 6 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    Function
    for TPBG gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:
         Genatlas biochemistry entry for TPBG:
    trophoblast glycoprotein

    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tpbg):
     cellular  mortality/aging  nervous system 

    TPBG for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Tpbgtm1Lex for TPBG
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TPBG 

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TPBG
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate TPBG (see all 26):
    hsa-miR-320a hsa-miR-34b* hsa-miR-548v hsa-miR-1205 hsa-miR-221 hsa-miR-548a-3p hsa-miR-1304 hsa-miR-548g
    SwitchGear 3'UTR luciferase reporter plasmid: TPBG 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TPBG (see all 7)
    OriGene shRNA RFP: TPBG
    OriGene siRNA: TPBG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TPBG
    Sirion Biotech Custom design and validation of potent shRNA sequences against TPBG 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TPBG
    Sirion Biotech Customized adenovirus for overexpression of TPBG 
    Sirion Biotech Customized adenovirus for potent knockdown of TPBG

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPBG (see all 5)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPBG 

    Cell Line
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    Search LifeMap BioReagents cell lines for TPBG
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPBG


    Pathways & Interactions
    for TPBG gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TPBG

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TPBG (Q136412, 3 ENSP000003587654) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GIPC1O149082, 3, ENSP000003406984MINT-62472 MINT-62471 MINT-62470 I2D: score=3 STRING: ENSP00000340698
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion NAS10366710

    TPBG for ontologies           About GeneDecksing



    Drugs & Compounds
    for TPBG gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TPBG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TPBG
    1 Novoseek chemical compound relationship for TPBG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trovax 98.2 4 16630022 (1), 19342962 (1), 16740766 (1), 18567615 (1)

    Search CenterWatch for drugs/clinical trials and news about TPBG 

    Transcripts
    for TPBG gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TPBG gene (2 alternative transcripts): 
    NM_001166392.1  NM_006670.4  

    Unigene Cluster for TPBG:

    Trophoblast glycoprotein
    Hs.82128  [show with all ESTs]
    Unigene Representative Sequence: NM_006670
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369750 ENST00000535040(uc003pjn.4) ENST00000543496(uc003pjo.3)


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TPBG
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate TPBG (see all 26):
    hsa-miR-320a hsa-miR-34b* hsa-miR-548v hsa-miR-1205 hsa-miR-221 hsa-miR-548a-3p hsa-miR-1304 hsa-miR-548g
    SwitchGear 3'UTR luciferase reporter plasmid: TPBG 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TPBG (see all 7)
    OriGene shRNA RFP: TPBG
    OriGene siRNA: TPBG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TPBG
    Sirion Biotech Custom design and validation of potent shRNA sequences against TPBG 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPBG (see all 2)
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    GenScript: all cDNA clones in your preferred vector (see all 2): TPBG (NM_006670)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPBG 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPBG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPBG

    Additional cDNA sequence: 

    AK074786.1 AK074790.1 AK291170.1 BC037161.2 Z29083.1 

    7 DOTS entries:

    DT.100652597  DT.214958  DT.91651841  DT.92008525  DT.95222154  DT.97843180  DT.102832548 

    24/181 AceView cDNA sequences (see all 181):

    CB242333 AA299402 BU684399 BU850301 AI474247 AA417953 AI648437 AI350569 
    BM699335 BF970819 AI141862 AI609599 NM_006670 BQ021793 BM669996 CA488673 
    BU541104 AI857997 CA454541 CA418954 BQ267567 AW192646 N22591 AI342491 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TPBG    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d
    SP1:                          -                 -                                 
    SP2:                          -           -     -     -                           
    SP3:                          -                 -     -     -                     
    SP4:                          -                                                   
    SP5:                                                                              


    ECgene alternative splicing isoforms for TPBG

    Expression
    for TPBG gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TPBG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTACATTTT
    TPBG Expression
    About this image

    TPBG expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainCerebral CortexBrain
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    BrainThalamusBrain
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)
    Midbrain dopaminergic-like neurons (Generation of midbra...)
    Nkx2-1 GFP+ cells (Efficient derivation...)

    See TPBG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TPBG

    SOURCE GeneReport for Unigene cluster: Hs.82128

    UniProtKB/Swiss-Prot: TPBG_HUMAN, Q13641
    Tissue specificity: Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for
    trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial
    cell types but is found on a variety of carcinoma

        SABiosciences Expression via Pathway-Focused PCR Array including TPBG: 
              Parkinson's Disease in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPBG

    Orthologs
    for TPBG gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TPBG gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tpbg1 , 5 trophoblast glycoprotein1, 5 83.37(n)1
    84.01(a)1    		   9 (46.40 cM)5
    219831  NM_001164792.11  NP_001158264.11 
     858423805 
    chicken
    (Gallus gallus)    		 Aves TPBG1 trophoblast glycoprotein 69.04(n)
    68.38(a)    		   772098  XM_001235285.2  XP_001235286.2 
    lizard
    (Anolis carolinensis)    		 Reptilia TPBG6
    		 --
    		 94(a)
    		 1 ↔ 1
    		 1(198107947-198108111)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.55482 Xenopus laevis transcribed sequence with moderate similarity more 78.76(n)    48030760 
    zebrafish
    (Danio rerio)    		 Actinopterygii tpbgb1 trophoblast glycoprotein b 52.76(n)
    49.14(a)    		   792712  XM_002664775.2  XP_002664821.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG69596
    		 --
    		 23(a)
    		 1 ↔ 1
    		 3R(7648424-7695183)
    worm
    (Caenorhabditis elegans)    		 Secernentea lron-36
    		 Protein LRON-3, isoform b
    		 21(a)
    		 1 ↔ 1
    		 X(15546646-15552165)


    ENSEMBL Gene Tree for TPBG (if available)
    TreeFam Gene Tree for TPBG (if available) 

    Paralogs
    for TPBG gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TPBG gene

    TPBG for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TPBG
    PGOHUM00000258595


    Genomic Variants
    for TPBG gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/118 NCBI SNPs in TPBG are shown (see all 118)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1892950361,2
    		--83071121(+) TATTTA/TTCCTT 1 -- us2k10--------
    rs1816076131,2
    		--83071159(+) AGATAG/TAGTGG 1 -- us2k10--------
    rs1450325081,2
    		--83071200(+) TAGGAA/GAGAAC 1 -- us2k10--------
    rs624313191,2
    		--83071334(+) AATGAT/CCCTAA 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1447246521,2
    		--83071414(+) AAAGGA/GAACAA 1 -- us2k10--------
    rs1851676481,2
    		--83071524(+) GGCAGA/GCAAAT 1 -- us2k10--------
    rs1896395951,2
    		--83071637(+) GAGTAC/TCGAAG 1 -- us2k10--------
    rs1815289121,2
    		--83071696(+) TGGAAA/GACACT 1 -- us2k10--------
    rs1387629281,2
    		--83071976(+) ATCATA/GCAGTA 2 -- us2k10--------
    rs1863405821,2
    		--83072047(+) AACCAA/CCACCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TPBG (83072923 - 83080545 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TPBG
         1 CNV: 32823

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPBG
    DNA2.0 Custom Variant and Variant Library Synthesis for TPBG

    Disorders / Diseases
    for TPBG gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TPBG for disorders           About GeneDecksing

    OMIM gene information: 190920    OMIM disorders: --

    16 diseases for TPBG:    About MalaCards
    non-small cell lung carcinoma    renal cell carcinoma    carcinoma    gastric cancer
    lung carcinoma    colorectal cancer    cervicitis    parkinson's disease
    vaccinia    breast cancer    cervical carcinoma    melanoma
    cervical cancer    lung cancer    esophagitis    prostatitis

    10/15 Novoseek disease relationships for TPBG gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma 47.8 14 7593330 (3), 16630022 (2), 18097562 (1), 8132670 (1) (see all 11)
    carcinoma renal cell 44.3 5 16222313 (3), 18004564 (1)
    melanoma b16 41.8 2 16758205 (1)
    colorectal cancer 40.8 7 18833005 (3), 8180020 (2), 16630022 (1), 18567615 (1)
    metastasis 40.4 6 8132670 (1), 12168897 (1), 9815581 (1), 9855063 (1) (see all 6)
    gastric carcinoma 36 8 9855063 (5), 1419629 (2), 16646078 (1)
    colorectal carcinoma 33.2 4 9815581 (3), 8180020 (1)
    tumors 29.4 15 16646078 (3), 12481437 (2), 16311730 (2), 9815581 (2) (see all 7)
    cancer 29.2 15 11708475 (3), 12481437 (2), 12003637 (2), 16222313 (1) (see all 10)
    cancer lung 24.4 3 11708475 (2), 11437414 (1)


    Export disorders for TPBG gene to outside databases

    Publications
    for TPBG gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TPBG gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with TPBG)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a cDNA encoding 5T4 oncofetal trophoblast glycoprotein: an antigen associated with metastasis contains leucine rich repeats. (PubMed id 8132670)1, 2, 3, 9 Myers K.A....Stern P.L. (1994)
    2. Attenuated recombinant vaccinia virus expressing oncofetal antigen (tumor-associated antigen) 5T4 induces active therapy of established tumors. (PubMed id 12481437)1, 2, 9 Mulryan K.... Carroll M.W. (2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. CD8 T-cell recognition of human 5T4 oncofetal antigen. (PubMed id 16646078)1, 9 Smyth L.J....Stern P.L. (2006)
    6. Metastasis-associated 5T4 antigen disrupts cell-cell contacts and induces cellular motility in epithelial cells. (PubMed id 8895545)1, 9 Carsberg C.J....Stern P.L. (1996)
    7. Metastasis-associated 5T4 oncofoetal antigen is concentrated at microvillus projections of the plasma membrane. (PubMed id 7593330)1, 9 Carsberg C.J....Stern P.L. (1995)
    8. Cell surface 5T4 antigen is transiently upregulated during early human embryonic stem cell differentiation: effect of 5T4 phenotype on neural lineage formation. (PubMed id 16616918)1, 9 Ward C.M....Stern P.L. (2006)
    9. An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases. (PubMed id 18833005)1, 9 Elkord E....Stern P.L. (2008)
    10. Organisation of the mouse and human 5T4 oncofoetal leucine-rich glycoprotein genes and expression in foetal and adult murine tissues. (PubMed id 10366710)1, 9 King K.W....Myers K.A. (1999)

    External Searches for TPBG gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing TPBG gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7162 HGNC: 12004 AceView: TPBG Ensembl:ENSG00000146242 euGenes: HUgn7162
    ECgene: TPBG H-InvDB: TPBG

    Other Databases showing TPBG gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TPBG gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TPBG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TPBG Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TPBG gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TPBG gene:
    Search GeneIP for patents involving TPBG

    GeneCards and IP:
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