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TP73-AS1 Gene

RNA gene   GIFtS: 32
GCID: GC01M003653

TP73 Antisense RNA 1

(Previous name: KIAA0495)
(Previous symbol: KIAA0495)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): antisense

Quality score for this RNA gene is 3

Aliases
TP73 Antisense RNA 11 2 3
KIAA04951 2 3
P53-Dependent Apoptosis Modulator1 3
PDAM2 3

External Ids:    HGNC: 290521   Entrez Gene: 572122   Ensembl: ENSG000002273727   UniProtKB: Q9UF723   
ORGUL members:         

Export aliases for TP73-AS1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TP73-AS1 Gene:
TP73-AS1 (TP73 antisense RNA 1) is an RNA gene, and is affiliated with the antisense RNA class.

UniProtKB/Swiss-Prot: T73AS_HUMAN, Q9UF72
Function: May modulate apoptosis via regulation of p53/TP53-dependent anti-apoptotic genes. Induces resistance of
the chemotherapy drug cisplatin in glioma cells when underexpressed




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TP73-AS1
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TP73-AS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.32   Ensembl cytogenetic band:  1p36.32   HGNC cytogenetic band: 1p36.32

TP73-AS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP73-AS1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M003653:  view genomic region     (about GC identifiers)

Start:
3,652,548 bp from pter      End:
3,663,937 bp from pter
Size:
11,390 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TP73-AS1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: T73AS_HUMAN, Q9UF72 (See protein sequence)
Recommended Name: Putative TP73 antisense gene protein 1 precursor  
Size: 201 amino acids; 20603 Da
Miscellaneous: This gene product may be present at undetectable level as Western blot analysis and
immunofluorescence staining failed to detect any signals
Caution: Product of a dubious CDS prediction

Explore the universe of human proteins at neXtProt for TP73-AS1: NX_Q9UF72


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
LNCRNA: Long non-coding RNAs

ProtoNet protein and cluster: Q9UF72


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: T73AS_HUMAN, Q9UF72
Function: May modulate apoptosis via regulation of p53/TP53-dependent anti-apoptotic genes. Induces resistance of
the chemotherapy drug cisplatin in glioma cells when underexpressed

Phenotypes:
     1 GenomeRNAi human phenotype for TP73-AS1:

 Synthetic lethal with Ras 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
T73AS_HUMAN, Q9UF72: Secreted (Potential)

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

Find genes that share ontologies with TP73-AS1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TP73-AS1
Interactions:

    Search GeneGlobe Interaction Network for TP73-AS1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for TP73-AS1 (T73AS)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TP73-AS1 gene: 
NM_207306.2  

Unigene Cluster for TP73-AS1:

TP73 antisense RNA 1
Hs.49658  [show with all ESTs]
Unigene Representative Sequence: NR_033711
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000418088(antisense) ENST00000452079(antisense) ENST00000419973(antisense) ENST00000423764(antisense) ENST00000587071(antisense)
ENST00000608600(antisense) ENST00000544565(antisense)
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Additional mRNA sequence: 

AB007964.1 AL133648.1 BC013872.2 BC035073.1 BC044603.1 BC089039.1 BC093699.1 BC111984.1 
NR_033708.1 NR_033709.1 NR_033710.1 NR_033711.1 NR_033712.1 

5 DOTS entries:

DT.100680877  DT.95358153  DT.95100185  DT.312264  DT.91656564 

Selected AceView cDNA sequences (see all 104):

BQ880317 CB215637 BQ672204 NM_207306 CB852850 AI420866 AL133648 AA989364 
AA923775 BI059969 BC013872 BF438683 BU197997 BF594471 BQ674074 AI905114 
BU678239 AW237143 AA725756 BV166906 AI050876 CD359309 AW510837 AB007964 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for TP73-AS1:none

TP73-AS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTCGGCCTAA
TP73-AS1 Expression
About this image

TP73-AS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.49658

UniProtKB/Swiss-Prot: T73AS_HUMAN, Q9UF72
Tissue specificity: Ubiquitous. Decreased expression in oligodendroglial tumors

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for TP73-AS1 (if available)
TreeFam Gene Tree for TP73-AS1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TP73-AS1 (see all 322)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs11818661,2
C,F,A,H--3653412(-) GGGCTG/TGGCAT 5 -- nc-transcript-variant13Minor allele frequency- T:0.24NA WA CSA EA 378
rs11818651,2
C,F,H--3653426(-) GGAAGG/ATGGGG 5 -- nc-transcript-variant24Minor allele frequency- A:0.21NS EA NA WA CSA 2347
rs1509203621,2
C--3653449(+) ACGCCA/GTCACA 5 -- nc-transcript-variant0--------
rs1411052661,2
C--3653667(+) AACGCC/TCTTTC 5 -- nc-transcript-variant0--------
rs1817876801,2
--3653766(+) AGCGTC/GAGAAA 5 -- nc-transcript-variant0--------
rs1468959341,2
--3653955(+) CTCCAC/TGCCCC 5 -- nc-transcript-variant0--------
rs1431216071,2
--3653972(+) GGAAA-/CACAGC 5 -- nc-transcript-variant0--------
rs1443199161,2
C--3653973(+) GAAAA-/CCCAGCC 5 -- nc-transcript-variant0--------
rs1865642391,2
--3654116(+) AAATCA/GGATTC 5 -- nc-transcript-variant0--------
rs1479503611,2
--3654145(+) TAGGCC/TGAGCA 5 -- nc-transcript-variant0--------

HapMap Linkage Disequilibrium report for TP73-AS1 (3652548 - 3663937 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for TP73-AS1 (see all 16):    About this table    
Variant IDTypeSubtypePubMed ID
esv994567CNV Deletion20482838
esv2729806CNV Deletion23290073
dgv113n71CNV Loss21882294
dgv110n71CNV Loss21882294
nsv871021CNV Loss21882294
nsv871323CNV Loss21882294
nsv871368CNV Loss21882294
dgv96n71CNV Loss21882294
nsv470687CNV Loss18288195
dgv99n71CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TP73-AS1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TP73-AS1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. KIAA0495/PDAM is frequently downregulated in oligodendroglial tumors and its knockdown by siRNA induces cisplatin resistance in glioma cells. (PubMed id 20477830)1, 2, 3 Pang J.C.... Ng H.K. (Brain Pathol. 2010)
  2. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2, 3 Seki N.... Ohara O. (DNA Res. 1997)
  3. A long non-coding RNA signature in glioblastoma multiforme predicts survival. (PubMed id 23726844)1, 3 Zhang X.Q....Leung G.K. (Neurobiol. Dis. 2013)
  4. Relative expression of TAp73 and I9Np73 isoforms. (PubMed id 22388545)1 Conforti F....Sayan B.S. (Aging (Albany NY) 2012)
  5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57212 HGNC: 29052 AceView: KIAA0495 Ensembl:ENSG00000227372 euGenes: HUgn57212
ECgene: TP73-AS1 H-InvDB: TP73-AS1

(According to HUGE)
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HUGE: KIAA0495

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TP73-AS1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TP73-AS1 gene:
Search GeneIP for patents involving TP73-AS1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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 Search Addgene for plasmids for TP73-AS1
  Search eBioscience for proteins for TP73-AS1
  Search eBioscience for elisas for TP73-AS1
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for TP73-AS1
 antibodies-online antibodies for TP73-AS1 (7 products)
 antibodies-online kits for TP73-AS1
 antibodies-online peptides for TP73-AS1
 antibodies-online proteins for TP73-AS1 (2 products)
       
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