Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TP73-AS1 Gene

Subcategory (RNA class) for TP73-AS1 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for TP73-AS1 Gene

  • TP73 Antisense RNA 1 2 3 4 5
  • P53-Dependent Apoptosis Modulator 2 3 4
  • KIAA0495 2 3 4
  • PDAM 3 4
  • TP73 Antisense RNA 1 (Non-Protein Coding) 3

External Ids for TP73-AS1 Gene

Previous HGNC Symbols for TP73-AS1 Gene

  • KIAA0495

Previous GeneCards Identifiers for TP73-AS1 Gene

  • GC01M003653

Summaries for TP73-AS1 Gene

GeneCards Summary for TP73-AS1 Gene

TP73-AS1 (TP73 Antisense RNA 1) is an RNA Gene, and is affiliated with the non-coding RNA class.

UniProtKB/Swiss-Prot for TP73-AS1 Gene

  • May modulate apoptosis via regulation of p53/TP53-dependent anti-apoptotic genes. Induces resistance of the chemotherapy drug cisplatin in glioma cells when underexpressed.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP73-AS1 Gene

Genomics for TP73-AS1 Gene

Regulatory Elements for TP73-AS1 Gene

Enhancers for TP73-AS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F003065 1.2 FANTOM5 ENCODE 68.3 +676.9 676871 9.4 PKNOX1 YBX1 ZNF48 GLIS2 ZNF143 ZNF416 ZNF548 ZNF263 REST CBX8 TP73-AS1 C1orf174 MORN1 ACTRT2 LOC100129534 SKI ENSG00000272153 PRDM16 LOC100420339 PIR58969
GH01F003687 1.5 FANTOM5 Ensembl ENCODE 35 +57.5 57532 3.7 HDGF PKNOX1 ARNT GLIS2 ZNF548 KDM4B JUNB SMARCA4 GLIS1 KLF1 TP73 TP73-AS1 C1orf174 ENSG00000272153 WRAP73 CEP104 LOC105378609 ENSG00000235131
GH01F003899 1 FANTOM5 ENCODE 30 -153.1 -153102 2.7 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 C1orf174 TP73-AS1 ENSG00000272153 DFFB LINC01777 ENSG00000227169 LINC01646 LRRC47 LINC01134 PIR33659
GH01F002984 0.2 ENCODE 24.9 +762.1 762067 1.3 YBX1 ZIC2 ZNF324 GLIS2 ZBTB48 ZNF366 ZNF354C PATZ1 SCRT2 ZNF263 TP73-AS1 SKI GC01P002988 PIR61730 GC01P002897
GH01F003695 1.2 Ensembl ENCODE 22.9 +51.2 51181 1.8 CTCF JUN ZNF514 RAD21 ZNF335 FOSL1 GATA3 ZFHX2 GLIS2 ZNF143 TP73-AS1 C1orf174 ENSG00000235131 LOC105378609
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TP73-AS1 on UCSC Golden Path with GeneCards custom track

Promoters for TP73-AS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000162896 173 1601 ARID4B SIN3A ETS1 GLIS2 ELK1 KDM4B SP3 MXD4 ZNF518A KAT8

Genomic Location for TP73-AS1 Gene

Chromosome:
1
Start:
3,735,601 bp from pter
End:
3,747,373 bp from pter
Size:
11,773 bases
Orientation:
Minus strand

Genomic View for TP73-AS1 Gene

Genes around TP73-AS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TP73-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TP73-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP73-AS1 Gene

Proteins for TP73-AS1 Gene

  • Protein details for TP73-AS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UF72-T73AS_HUMAN
    Recommended name:
    Putative TP73 antisense gene protein 1
    Protein Accession:
    Q9UF72

    Protein attributes for TP73-AS1 Gene

    Size:
    201 amino acids
    Molecular mass:
    20603 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene product may be present at undetectable level as Western blot analysis and immunofluorescence staining failed to detect any signals.

neXtProt entry for TP73-AS1 Gene

Post-translational modifications for TP73-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TP73-AS1 Gene

Domains & Families for TP73-AS1 Gene

Protein Domains for TP73-AS1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TP73-AS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TP73-AS1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TP73-AS1 Gene

Function for TP73-AS1 Gene

Molecular function for TP73-AS1 Gene

UniProtKB/Swiss-Prot Function:
May modulate apoptosis via regulation of p53/TP53-dependent anti-apoptotic genes. Induces resistance of the chemotherapy drug cisplatin in glioma cells when underexpressed.

Phenotypes for TP73-AS1 Gene

GenomeRNAi human phenotypes for TP73-AS1:
genes like me logo Genes that share phenotypes with TP73-AS1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TP73-AS1 Gene

Localization for TP73-AS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP73-AS1 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for TP73-AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with TP73-AS1: view

No data available for Subcellular locations from COMPARTMENTS for TP73-AS1 Gene

Pathways & Interactions for TP73-AS1 Gene

SuperPathways for TP73-AS1 Gene

No Data Available

Interacting Proteins for TP73-AS1 Gene

Gene Ontology (GO) - Biological Process for TP73-AS1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TP73-AS1 Gene

Transcripts for TP73-AS1 Gene

Unigene Clusters for TP73-AS1 Gene

TP73 antisense RNA 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TP73-AS1 Gene

No ASD Table

Relevant External Links for TP73-AS1 Gene

GeneLoc Exon Structure for
TP73-AS1
ECgene alternative splicing isoforms for
TP73-AS1

Expression for TP73-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TP73-AS1 Gene

SOURCE GeneReport for Unigene cluster for TP73-AS1 Gene:

Hs.49658

mRNA Expression by UniProt/SwissProt for TP73-AS1 Gene:

Q9UF72-T73AS_HUMAN
Tissue specificity: Ubiquitous. Decreased expression in oligodendroglial tumors.
genes like me logo Genes that share expression patterns with TP73-AS1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TP73-AS1 Gene

Orthologs for TP73-AS1 Gene

Evolution for TP73-AS1 Gene

ENSEMBL:
Gene Tree for TP73-AS1 (if available)
TreeFam:
Gene Tree for TP73-AS1 (if available)

No data available for Orthologs for TP73-AS1 Gene

Paralogs for TP73-AS1 Gene

No data available for Paralogs for TP73-AS1 Gene

Variants for TP73-AS1 Gene

Sequence variations from dbSNP and Humsavar for TP73-AS1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1047928 -- 3,736,053(-) AAGCA(C/G)GATCT nc-transcript-variant, utr-variant-3-prime
rs1047932 -- 3,735,798(-) GATGT(G/T)AGCTG downstream-variant-500B, utr-variant-3-prime
rs10797409 -- 3,741,673(+) AATGT(A/G)CAGTC intron-variant
rs10910020 -- 3,743,777(+) TAGCC(A/G)AGCTT intron-variant
rs111368706 -- 3,737,932(+) AGCCC(A/G)CCTCA intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TP73-AS1 Gene

Variant ID Type Subtype PubMed ID
dgv13n100 CNV gain 25217958
esv2758916 CNV gain 17122850
esv3585042 CNV gain 21293372
esv994567 CNV deletion 20482838
nsv1001715 CNV loss 25217958
nsv1012423 CNV gain 25217958
nsv460061 CNV loss 19166990
nsv470687 CNV loss 18288195
nsv478669 CNV novel sequence insertion 20440878
nsv545129 CNV loss 21841781
nsv830314 CNV gain+loss 17160897
nsv830425 CNV gain 17160897
nsv951959 CNV deletion 24416366

Relevant External Links for TP73-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TP73-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TP73-AS1 Gene

Disorders for TP73-AS1 Gene

Relevant External Links for TP73-AS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TP73-AS1

No disorders were found for TP73-AS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TP73-AS1 Gene

Publications for TP73-AS1 Gene

  1. KIAA0495/PDAM is frequently downregulated in oligodendroglial tumors and its knockdown by siRNA induces cisplatin resistance in glioma cells. (PMID: 20477830) Pang J.C. … Ng H.K. (Brain Pathol. 2010) 2 3 4 64
  2. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3 4 64
  3. A long non-coding RNA signature in glioblastoma multiforme predicts survival. (PMID: 23726844) Zhang X.Q. … Leung G.K. (Neurobiol. Dis. 2013) 2 3 64
  4. Epigenetic silencing of a long non-coding RNA KIAA0495 in multiple myeloma. (PMID: 26410378) Wong K.Y. … Chim C.S. (Mol. Cancer 2015) 3 64
  5. Relative expression of TAp73 and I9Np73 isoforms. (PMID: 22388545) Conforti F. … Sayan B.S. (Aging (Albany NY) 2012) 3 64

Products for TP73-AS1 Gene

Sources for TP73-AS1 Gene

Content
Loading form....