TP73-AS1 Gene
RNA gene GIFtS: 32
GCID: GC01M003653
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TP73 antisense RNA 1(Previous names: KIAA0495, TP73 antisense RNA 1 (non-protein coding) )
(Previous symbol: KIAA0495)
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Aliases
for TP73-AS1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): lncRNA
Quality score for this RNA gene is 3
| Aliases |
|---|
| TP73 Antisense RNA 11 2 3 | | KIAA04951 2 3 | | PDAM1 2 3 | | TP73 Antisense RNA 1 (Non-Protein Coding)1 | | P53-Dependent Apoptosis Modulator3 |
| External Ids: | HGNC: 290521 | Entrez Gene: 572122 | Ensembl: ENSG000002273727 | UniProtKB: Q9UF723 | | ORGUL members: | |
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| NONCODE:n409345 n345873 n380672 n377968 n409346 | see all 9 |
Export aliases for TP73-AS1 gene to outside databases
|---|
Summaries
for TP73-AS1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: T73AS_HUMAN, Q9UF72Function: May modulate apoptosis via regulation of p53/TP53-dependent anti-apoptotic genes. Induces resistance of thechemotherapy drug cisplatin in glioma cells when underexpressed
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Genomic Views
for TP73-AS1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004350.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TP73-AS1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TP73-AS1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP73-AS1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.32 Ensembl cytogenetic band: 1p36.32 HGNC cytogenetic band: 1p36.32TP73-AS1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M003653: view genomic region
(about GC identifiers)
Start:
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3,652,548 bp from pter |
End:
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3,663,937 bp from pter |
Size:
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11,390 bases |
Orientation:
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minus strand |
ORGUL member locations:
Legend (see complete legend)
- n378918
- n409347
- n409345
- n409346
- n377968
- n378027
- n345873
- n378145
- n380672
3652547 3658242 3663937 chr1
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Proteins
for TP73-AS1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: T73AS_HUMAN, Q9UF72 (See
protein sequence)Recommended Name: Putative TP73 antisense gene protein 1 precursor Size: 201 amino acids; 20603 Da
Subcellular location: Secreted (Potential)
Miscellaneous: This gene product may be present at undetectable level as Western blot analysis and immunofluorescencestaining failed to detect any signals
Caution: Product of a dubious CDS predictionExplore the universe of human proteins at neXtProt for TP73-AS1: NX_Q9UF72
TP73-AS1 Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
TP73-AS1 for ontologies About GeneDecksing
TP73-AS1 Antibody Products:
Assay Products for TP73-AS1: |
Protein
Domains /
Families
for TP73-AS1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9UF72 |
Function
for TP73-AS1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: T73AS_HUMAN, Q9UF72Function: May modulate apoptosis via regulation of p53/TP53-dependent anti-apoptotic genes. Induces resistance of thechemotherapy drug cisplatin in glioma cells when underexpressed
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TP73-AS1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP73-AS1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for TP73-AS1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TP73-AS1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP73-AS1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP73-AS1 |
1 GenomeRNAi human phenotype for TP73-AS1:
|
Pathways & Interactions
for TP73-AS1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TP73-AS1
|
Drugs & Compounds
for TP73-AS1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TP73-AS1
Search CenterWatch for drugs/clinical trials and news about TP73-AS1
|
Transcripts
for TP73-AS1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TP73-AS1 gene: NM_207306.2 Unigene Cluster for TP73-AS1: TP73 antisense RNA 1 Hs.49658 [show with all ESTs]Unigene Representative Sequence: NR_0337116 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000418088(uc001akt.4) ENST00000452079(uc021ofj.1 uc021ofk.1 uc021ofl.1 uc009vlm.3)
ENST00000419973 ENST00000423764 ENST00000587071 ENST00000544565
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TP73-AS1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP73-AS1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for TP73-AS1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TP73-AS1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP73-AS1 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TP73-AS1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TP73-AS1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TP73-AS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP73-AS1 |
Additional cDNA sequence: AB007964.1 AL133648.1 BC013872.2 BC035073.1 BC044603.1 BC089039.1 BC093699.1 BC111984.1 NR_033708.1 NR_033709.1 NR_033710.1 NR_033711.1 NR_033712.1 5 DOTS entries: DT.100680877 DT.95358153 DT.95100185 DT.312264 DT.91656564 24/104 AceView cDNA sequences (see all 104): BF438683 CB215637 CB852850 AI420866 AA989364 NM_207306 BF594471 BI059969 BQ674074 BQ880317 BC013872 AI905114 AL133648 BQ672204 AA923775 BU197997 BU941708 CD359309 BE746404 BQ429058 AA026260 AI419008 BG702684 AB007964
GeneLoc Exon Structure
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Expression
for TP73-AS1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for TP73-AS1:none
TP73-AS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCGGCCTAA
About this image
Genevestigator expression for TP73-AS1
SOURCE GeneReport for Unigene cluster: Hs.49658
UniProtKB/Swiss-Prot: T73AS_HUMAN, Q9UF72Tissue specificity: Ubiquitous. Decreased expression in oligodendroglial tumors
SABiosciences Custom PCR Arrays for TP73-AS1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TP73-AS1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TP73-AS1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TP73-AS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP73-AS1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP73-AS1 |
Orthologs
for TP73-AS1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for TP73-AS1 (if available)
TreeFam Gene Tree for TP73-AS1 (if available) |
Paralogs
for TP73-AS1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TP73-AS1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TP73-AS1 (3652548 - 3663937 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TP73-AS1: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for TP73-AS1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TP73-AS1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TP73-AS1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TP73-AS1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- KIAA0495/PDAM Is Frequently Downregulated in Oligoden droglial Tumors and Its Knockdown by siRNA Induces Cisplatin Resistance in Glio ma Cells. (PubMed id 20477830)1, 2, 3 Pang J.C....Ng H.K. (2010)
- Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2, 3 Seki N.... Ohara O. (1997)
- Relative expression of TAp73 and DNp73 isoforms. (PubMed id 22388545)1 Conforti F....Sayan B.S. (2012)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TP73-AS1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TP73-AS1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing TP73-AS1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TP73-AS1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TP73-AS1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TP73-AS1 gene:
Search GeneIP for patents involving TP73-AS1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TP73-AS1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for TP73-AS1 | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TP73-AS1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TP73-AS1 | | | OriGene Protein Over-expression Lysate for TP73-AS1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for TP73-AS1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP73-AS1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TP73-AS1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TP73-AS1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TP73-AS1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TP73-AS1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP73-AS1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TP73-AS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP73-AS1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TP73-AS1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP73-AS1 |
|  |  |  | | | | Search ThermoFisher Antibodies for TP73-AS1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP73-AS1 |
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