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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TP73-AS1 Gene

RNA gene   GIFtS: 33
GCID: GC01M003653

TP73 Antisense RNA 1

(Previous names: KIAA0495, TP73 antisense RNA 1 (non-protein coding))
(Previous symbol: KIAA0495)
  Search for TP73-AS1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 3

Aliases
TP73 Antisense RNA 11 2 3
KIAA04951 2 3
P53-Dependent Apoptosis Modulator1 3
PDAM2 3
TP73 Antisense RNA 1 (Non-Protein Coding)1

External Ids:    HGNC: 290521   Entrez Gene: 572122   Ensembl: ENSG000002273727   UniProtKB: Q9UF723   
ORGUL members:         
NONCODE14:n378027 n409345 n409346 n409347 n345873 see all 9      

Export aliases for TP73-AS1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TP73-AS1 Gene: 
TP73-AS1 (TP73 antisense RNA 1) is an RNA gene, and is affiliated with the lncRNA class.

UniProtKB/Swiss-Prot: T73AS_HUMAN, Q9UF72
Function: May modulate apoptosis via regulation of p53/TP53-dependent anti-apoptotic genes. Induces resistance of
the chemotherapy drug cisplatin in glioma cells when underexpressed




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004350.19  NC_018912.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TP73-AS1
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP73-AS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.32   Ensembl cytogenetic band:  1p36.32   HGNC cytogenetic band: 1p36.32

TP73-AS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP73-AS1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M003653:  view genomic region     (about GC identifiers)

Start:
3,652,548 bp from pter      End:
3,663,937 bp from pter
Size:
11,390 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TP73-AS1

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T73AS_HUMAN, Q9UF72 (See protein sequence)
Recommended Name: Putative TP73 antisense gene protein 1 precursor  
Size: 201 amino acids; 20603 Da
Subcellular location: Secreted (Potential)
Miscellaneous: This gene product may be present at undetectable level as Western blot analysis and
immunofluorescence staining failed to detect any signals
Caution: Product of a dubious CDS prediction

Explore the universe of human proteins at neXtProt for TP73-AS1: NX_Q9UF72

TP73-AS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

TP73-AS1 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
LNCRNA: Long non-coding RNAs

ProtoNet protein and cluster: Q9UF72


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: T73AS_HUMAN, Q9UF72
Function: May modulate apoptosis via regulation of p53/TP53-dependent anti-apoptotic genes. Induces resistance of
the chemotherapy drug cisplatin in glioma cells when underexpressed

Phenotypes:
     1 GenomeRNAi human phenotype for TP73-AS1:

 Synthetic lethal with Ras 

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TP73-AS1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
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Browse Tocris compounds for TP73-AS1 (T73AS)

Search CenterWatch for drugs/clinical trials and news about TP73-AS1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TP73-AS1 gene: 
NM_207306.2  

Unigene Cluster for TP73-AS1:

TP73 antisense RNA 1
Hs.49658  [show with all ESTs]
Unigene Representative Sequence: NR_033711
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000418088(uc001akt.4) ENST00000452079(uc021ofj.1 uc021ofk.1 uc021ofl.1 uc009vlm.3)
ENST00000419973 ENST00000423764 ENST00000587071 ENST00000544565
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Additional mRNA sequence: 

AB007964.1 AL133648.1 BC013872.2 BC035073.1 BC044603.1 BC089039.1 BC093699.1 BC111984.1 
NR_033708.1 NR_033709.1 NR_033710.1 NR_033711.1 NR_033712.1 

5 DOTS entries:

DT.100680877  DT.95358153  DT.95100185  DT.312264  DT.91656564 

24/104 AceView cDNA sequences (see all 104):

BC013872 AI905114 CB852850 BI059969 BQ672204 CB215637 BQ880317 BF438683 
AA989364 NM_207306 BQ674074 AL133648 AI420866 BU197997 BF594471 AA923775 
AI160130 AA725756 BM725718 BE350299 BU521233 AA281404 BC044603 BV166906 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for TP73-AS1:none

TP73-AS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTCGGCCTAA
TP73-AS1 Expression
About this image


Genevestigator expression for TP73-AS1

SOURCE GeneReport for Unigene cluster: Hs.49658

UniProtKB/Swiss-Prot: T73AS_HUMAN, Q9UF72
Tissue specificity: Ubiquitous. Decreased expression in oligodendroglial tumors

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for TP73-AS1 (if available)
TreeFam Gene Tree for TP73-AS1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/322 SNPs in TP73-AS1 are shown (see all 322)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs11818661,2
C,F,A,H--3653412(-) GGGCTG/TGGCAT 5 -- nc-transcript-variant13Minor allele frequency- T:0.24NA WA CSA EA 378
rs11818651,2
C,F,H--3653426(-) GGAAGG/ATGGGG 5 -- nc-transcript-variant24Minor allele frequency- A:0.21NS EA NA WA CSA 2347
rs1509203621,2
C--3653449(+) ACGCCA/GTCACA 5 -- nc-transcript-variant0--------
rs1411052661,2
C--3653667(+) AACGCC/TCTTTC 5 -- nc-transcript-variant0--------
rs1817876801,2
--3653766(+) AGCGTC/GAGAAA 5 -- nc-transcript-variant0--------
rs1468959341,2
--3653955(+) CTCCAC/TGCCCC 5 -- nc-transcript-variant0--------
rs1431216071,2
--3653972(+) GGAAA-/CACAGC 5 -- nc-transcript-variant0--------
rs1443199161,2
C--3653973(+) GAAAA-/CCCAGCC 5 -- nc-transcript-variant0--------
rs1865642391,2
--3654116(+) AAATCA/GGATTC 5 -- nc-transcript-variant0--------
rs1479503611,2
--3654145(+) TAGGCC/TGAGCA 5 -- nc-transcript-variant0--------

HapMap Linkage Disequilibrium report for TP73-AS1 (3652548 - 3663937 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/16 variations for TP73-AS1 (see all 16):    About this table     
Variant IDTypeSubtypePubMed ID
esv994567CNV Deletion20482838
esv2729806CNV Deletion23290073
dgv113n71CNV Loss21882294
dgv110n71CNV Loss21882294
nsv871021CNV Loss21882294
nsv871323CNV Loss21882294
nsv871368CNV Loss21882294
dgv96n71CNV Loss21882294
nsv470687CNV Loss18288195
dgv99n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TP73-AS1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TP73-AS1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. KIAA0495/PDAM Is Frequently Downregulated in Oligoden droglial Tumors and Its Knockdown by siRNA Induces Cisplatin Resistance in Glio ma Cells. (PubMed id 20477830)1, 2, 3 Pang J.C....Ng H.K. (2010)
  2. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2, 3 Seki N.... Ohara O. (1997)
  3. Relative expression of TAp73 and DNp73 isoforms. (PubMed id 22388545)1 Conforti F....Sayan B.S. (2012)
  4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 57212 HGNC: 29052 AceView: KIAA0495 Ensembl:ENSG00000227372 euGenes: HUgn57212
ECgene: TP73-AS1 H-InvDB: TP73-AS1

(According to HUGE)
About This Section
HUGE: KIAA0495

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TP73-AS1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TP73-AS1 gene:
Search GeneIP for patents involving TP73-AS1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.
 Search LifeMap BioReagents cell lines for TP73-AS1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP73-AS1
 Browse SwitchGear 3'UTR luciferase reporter plasmids for TP73-AS1
 Browse SwitchGear Promoter luciferase reporter plasmids for TP73-AS1
 Search ThermoFisher Antibodies for TP73-AS1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP73-AS1
 inGenious Targeting Laboratory - Custom generated mouse model solutions for TP73-AS1
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TP73-AS1
Customized:
 lentivirus for stable overexpression of TP73-AS1
 lentivirus expression plasmids for stable overexpression of TP73-AS1
 adenovirus for overexpression of TP73-AS1
 Search LSBio for Antibodies for TP73-AS1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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