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Aliases for TP73-AS1 Gene

Subcategory (RNA class) for TP73-AS1 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for TP73-AS1 Gene

  • TP73 Antisense RNA 1 2 3 4 5
  • P53-Dependent Apoptosis Modulator 2 3 4
  • KIAA0495 2 3 4
  • PDAM 3 4
  • TP73 Antisense RNA 1 (Non-Protein Coding) 3

External Ids for TP73-AS1 Gene

Previous HGNC Symbols for TP73-AS1 Gene

  • KIAA0495

Previous GeneCards Identifiers for TP73-AS1 Gene

  • GC01M003653

Summaries for TP73-AS1 Gene

GeneCards Summary for TP73-AS1 Gene

TP73-AS1 (TP73 Antisense RNA 1) is an RNA Gene, and is affiliated with the non-coding RNA class.

UniProtKB/Swiss-Prot for TP73-AS1 Gene

  • May modulate apoptosis via regulation of p53/TP53-dependent anti-apoptotic genes. Induces resistance of the chemotherapy drug cisplatin in glioma cells when underexpressed.

Additional gene information for TP73-AS1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP73-AS1 Gene

Genomics for TP73-AS1 Gene

Regulatory Elements for TP73-AS1 Gene

Enhancers for TP73-AS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H003899 1.8 FANTOM5 ENCODE dbSUPER 104.2 -153.1 -153102 2 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZFP41 MEF2D SSRP1 TP73-AS1 C1orf174 WRAP73 ENSG00000272153 DFFB CEP104 LINC01777 ENSG00000227169 LINC01646 MEGF6
GH01H003318 1.9 FANTOM5 Ensembl ENCODE dbSUPER 24.3 +425.7 425723 6 PKNOX1 MLX ZFP64 ARID4B FEZF1 DMAP1 ZNF2 SLC30A9 ZNF143 SP5 C1orf174 WRAP73 TP73-AS1 ENSG00000272153 ENSG00000233234 ENSG00000231630 RER1 CEP104 ENSG00000225931 TNFRSF14
GH01H002986 0.8 dbSUPER 52.9 +759.4 759429 2 ZNF473 ZNF133 ZNF704 ZNF195 YBX1 SALL2 GLI4 ZNF514 ZFHX2 ZNF776 TP73-AS1 ENSG00000234396 ENSG00000272153 LOC100129534 MORN1 WRAP73 DFFB C1orf174 ACTRT2 FAAP20
GH01H003676 1.5 FANTOM5 Ensembl ENCODE 25.1 +69.4 69366 3 TBL1XR1 RB1 YBX1 BMI1 NFXL1 ZBTB40 BATF ZNF143 ATF7 ZNF548 TP73-AS1 C1orf174 TP73 DFFB WRAP73 MEGF6 LOC105378609 ENSG00000235131
GH01H003311 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.7 +433.6 433587 3 PKNOX1 ATF1 ARID4B ZNF2 ATF7 FOS SMARCB1 ZNF592 SMARCA4 KDM1A TP73-AS1 C1orf174 ENSG00000272153 PRDM16 LOC105378604 GC01P003290
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TP73-AS1 on UCSC Golden Path with GeneCards custom track

Promoters for TP73-AS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000000513 173 1201 ARID4B SIN3A ETS1 GLIS2 ELK1 ATF7 RUNX3 SP3 MXD4 ZNF518A

Genomic Location for TP73-AS1 Gene

Chromosome:
1
Start:
3,735,601 bp from pter
End:
3,747,373 bp from pter
Size:
11,773 bases
Orientation:
Minus strand

Genomic View for TP73-AS1 Gene

Genes around TP73-AS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TP73-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TP73-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP73-AS1 Gene

Proteins for TP73-AS1 Gene

  • Protein details for TP73-AS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UF72-T73AS_HUMAN
    Recommended name:
    Putative TP73 antisense gene protein 1
    Protein Accession:
    Q9UF72

    Protein attributes for TP73-AS1 Gene

    Size:
    201 amino acids
    Molecular mass:
    20603 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene product may be present at undetectable level as Western blot analysis and immunofluorescence staining failed to detect any signals.

neXtProt entry for TP73-AS1 Gene

Post-translational modifications for TP73-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TP73-AS1 Gene

Domains & Families for TP73-AS1 Gene

Gene Families for TP73-AS1 Gene

Protein Domains for TP73-AS1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TP73-AS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TP73-AS1: view

No data available for UniProtKB/Swiss-Prot for TP73-AS1 Gene

Function for TP73-AS1 Gene

Molecular function for TP73-AS1 Gene

UniProtKB/Swiss-Prot Function:
May modulate apoptosis via regulation of p53/TP53-dependent anti-apoptotic genes. Induces resistance of the chemotherapy drug cisplatin in glioma cells when underexpressed.

Phenotypes From GWAS Catalog for TP73-AS1 Gene

Phenotypes for TP73-AS1 Gene

GenomeRNAi human phenotypes for TP73-AS1:
genes like me logo Genes that share phenotypes with TP73-AS1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TP73-AS1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TP73-AS1 Gene

Localization for TP73-AS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP73-AS1 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for TP73-AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with TP73-AS1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TP73-AS1 Gene

Pathways & Interactions for TP73-AS1 Gene

SuperPathways for TP73-AS1 Gene

No Data Available

Interacting Proteins for TP73-AS1 Gene

Gene Ontology (GO) - Biological Process for TP73-AS1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TP73-AS1 Gene

Drugs & Compounds for TP73-AS1 Gene

No Compound Related Data Available

Transcripts for TP73-AS1 Gene

Unigene Clusters for TP73-AS1 Gene

TP73 antisense RNA 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TP73-AS1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TP73-AS1 Gene

No ASD Table

Relevant External Links for TP73-AS1 Gene

GeneLoc Exon Structure for
TP73-AS1
ECgene alternative splicing isoforms for
TP73-AS1

Expression for TP73-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TP73-AS1 Gene

SOURCE GeneReport for Unigene cluster for TP73-AS1 Gene:

Hs.49658

mRNA Expression by UniProt/SwissProt for TP73-AS1 Gene:

Q9UF72-T73AS_HUMAN
Tissue specificity: Ubiquitous. Decreased expression in oligodendroglial tumors.
genes like me logo Genes that share expression patterns with TP73-AS1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TP73-AS1 Gene

Orthologs for TP73-AS1 Gene

Evolution for TP73-AS1 Gene

ENSEMBL:
Gene Tree for TP73-AS1 (if available)
TreeFam:
Gene Tree for TP73-AS1 (if available)

No data available for Orthologs for TP73-AS1 Gene

Paralogs for TP73-AS1 Gene

No data available for Paralogs for TP73-AS1 Gene

Variants for TP73-AS1 Gene

Sequence variations from dbSNP and Humsavar for TP73-AS1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000118289 -- 3,736,068(+) GAGCA(C/G)TATTA nc-transcript-variant, utr-variant-3-prime
rs1000232500 -- 3,736,307(+) CCCAC(G/T)TGAGT intron-variant, nc-transcript-variant, downstream-variant-500B
rs1000244019 -- 3,739,694(+) TGATG(A/C)CCTCT intron-variant, nc-transcript-variant
rs1000316222 -- 3,740,087(+) GATGA(A/T)CTCTA intron-variant, nc-transcript-variant
rs1000429954 -- 3,740,067(+) CCCAC(A/G)CAATC intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TP73-AS1 Gene

Variant ID Type Subtype PubMed ID
dgv13n100 CNV gain 25217958
esv2758916 CNV gain 17122850
esv3585042 CNV gain 21293372
esv994567 CNV deletion 20482838
nsv1001715 CNV loss 25217958
nsv1012423 CNV gain 25217958
nsv460061 CNV loss 19166990
nsv470687 CNV loss 18288195
nsv478669 CNV novel sequence insertion 20440878
nsv545129 CNV loss 21841781
nsv830314 CNV gain+loss 17160897
nsv830425 CNV gain 17160897
nsv951959 CNV deletion 24416366

Relevant External Links for TP73-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TP73-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TP73-AS1 Gene

Disorders for TP73-AS1 Gene

Relevant External Links for TP73-AS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TP73-AS1

No disorders were found for TP73-AS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TP73-AS1 Gene

Publications for TP73-AS1 Gene

  1. KIAA0495/PDAM is frequently downregulated in oligodendroglial tumors and its knockdown by siRNA induces cisplatin resistance in glioma cells. (PMID: 20477830) Pang JC … Ng HK (Brain pathology (Zurich, Switzerland) 2010) 2 3 4 60
  2. The long non-coding RNA TP73-AS1 modulates HCC cell proliferation through miR-200a-dependent HMGB1/RAGE regulation. (PMID: 28403886) Li S … Fan XG (Journal of experimental & clinical cancer research : CR 2017) 2 3 60
  3. A long non-coding RNA signature in glioblastoma multiforme predicts survival. (PMID: 23726844) Zhang XQ … Leung GK (Neurobiology of disease 2013) 2 3 60
  4. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4 60
  5. A TP73-AS1/miR-200a/ZEB1 regulating loop promotes breast cancer cell invasion and migration. (PMID: 28857253) Zou Q … Yao J (Journal of cellular biochemistry 2017) 3 60

Products for TP73-AS1 Gene

Sources for TP73-AS1 Gene

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