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TP73 Gene

protein-coding GIFtS: 65

GC01P003592

tumor protein p73
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
OTTHUMP00000000662 ^²
P73 ^¹, ², ³

Descriptions
p53-like transcription factor ^², ³
p53-related protein ^², ³
tumor protein p73 ^²

External Ids
HGNC: 12003¹
Entrez Gene: 7161²
UniProtKB: O15350³
Ensembl: ENSG00000078900⁷

Search outside databases for aliases for TP73 gene

Previous GC identifers: GC01P003007 GC01P003526 GC01P003142 GC01P003352 GC01P003283

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TP73:

This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors

involved in cellular responses to stress and development. The family members include p53, p63, and

p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate

p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with

each other in many ways involving direct or indirect protein interactions, resulting in regulation

of the same target gene promoters or regulation of each other's promoters. The p73 protein is

expressed at very low levels in normal tissues and is differentially expressed in a number of

tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters,

alternate translation initiation sites, and multiple splice variations. Theoretically this can

account for 29 different p73 isoforms; however, the biological validity and the full-length nature

of most variants have not been determined. [provided by RefSeq]

UniProtKB/Swiss-Prot: P73_HUMAN, O15350

Function: Participates in the apoptotic response to DNA damage. Isoforms containing the

transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block

the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein

Gene Wiki entry for TP73 (P73)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TP73 gene

Entrez Gene cytogenetic band: 1p36.3 Ensembl cytogenetic band: 1p36.32 HGNC cytogenetic band: 1p36.3

TP73 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P003592: (about GC identifiers)

Start:	3,558,989 bp from pter
End:	3,639,716 bp from pter
Size:	80,728 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004321.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: P73_HUMAN, O15350 (See protein sequence)

Recommended Name: Tumor protein p73

Size: 636 amino acids; 69623 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subunit: Found in a complex with p53/TP53 and CABLES1. The C-terminal oligomerization domain binds

to the ABL tyrosine kinase SH3 domain. Interacts with HECW2. Isoform Beta interacts homotypically

and with p53/TP53, whereas isoform Alpha does not. Isoform Gamma interacts homotypically and with

all p73 isoforms. Isoform Delta interacts with isoform Gamma, isoform Alpha, and homotypically.

Isoforms Alpha and Beta interact with HIPK2. Isoform Alpha interacts with RANBP9. Isoform Beta

interacts with WWOX

Subcellular location: Nucleus. Note=Accumulates in the nucleus in response to DNA damage

Miscellaneous: Activated and stabilized by interaction with RANBP9

PDB structure from and Proteopedia :

1COK (3D)

1DXS (3D)

Secondary accessions: O15351 Q17RN8 Q5TBV5 Q5TBV6 Q8NHW9 Q8TDY5 Q8TDY6 Q9NTK8

Alternative promoter usage, Alternative splicing: 9 isoforms: O15350-1 O15350-2 O15350-3 O15350-4 O15350-5 O15350-6 O15350-8 O15350-9

O15350-10

Post-translational modifications:

Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal

degradation but does not affect transcriptional activity¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001119712.1 NP_001119713.1 NP_001119714.1 NP_005418.1

ENSEMBL proteins:

ENSP00000367529 ENSP00000367534 ENSP00000367537 ENSP00000367539 ENSP00000346423 ENSP00000367545

ENSP00000350366 ENSP00000340740

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (p73 Delta N, p73 alpha, p73, p73 alpha+beta, p73 beta)
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: TP73

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

About this table

Antibodies for TP73:

	Invitrogen Antibodies for TP73
	Millipore Mono- and Polyclonal Antibodies for the study of TP73
	Sigma-Aldrich Antibodies for TP73
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (p73 Delta N, p73 alpha, p73, p73 alpha+beta, p73 beta), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TP73)
	Novus Biologicals Antibodies for TP73

Assays for TP73:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O15350

ProtoNet protein and cluster: O15350

3 Blocks protein families:

IPB001660 Sterile alpha motif SAM

IPB010991 p53

IPB011510 Sterile alpha motif homology 2

UniProtKB/Swiss-Prot: P73_HUMAN, O15350

Domain: Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal

oligomerization domain that binds to the ABL tyrosine kinase SH3 domain

Domain: The WW-binding motif mediates interaction with WWOX

Similarity: Belongs to the p53 family

Similarity: Contains 1 SAM (sterile alpha motif) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TP73)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TP73)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001126240

Applied Biosystems Silencer® siRNAs for TP73

Sigma-Aldrich siRNA for TP73

Sigma-Aldrich shRNA Panels and shRNA for TP73

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001126240
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001126240
untagged cDNA clones in CMV expression vector (see all 4): NM_001126240

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005427

UniProtKB/Swiss-Prot: P73_HUMAN, O15350

Function: Participates in the apoptotic response to DNA damage. Isoforms containing the

transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block

the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein

Induction: Not induced by DNA damage. Isoforms lacking the transactivation domain block gene

induction

Genatlas biochemistry entry for TP73:

tumor protein 73,with two alternatively spliced isoforms,alpha and beta,activating transcription of

p53-responsive genes and inhibiting cell growth by inducing apoptosis,also target of ABL1 (c-ABL)

in response to DNA damage in a mismatch repair-dependent apoptosis,monoallelicaly expressed

(?,paternally imprinted),frequently deleted in neuroblastoma in advanced stage but unlikely to be

a suppressor gene in neuroblastoma,and other tumors (see TSG1A) (not in oligodendrogliomas,in

colorectal or in oesophageal carcinomas),overexpressed in bladder carcinoma

15/21 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Trp73) (see all 21 ):

	behavior/neurological	cellular	craniofacial	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hearing/vestibular/ear	homeostasis/metabolism
immune system	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	nervous system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IDA	15678106
GO:0005515	protein binding	IPI	10469568 11748232 14729977
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

4 Sigma-Aldrich "Your Favorite Gene" Pathways for TP73 (Your Favorite Gene powered by Ingenuity)

14-3-3-mediated Signaling
p53 Signaling
ATM Signaling
Aryl Hydrocarbon Receptor Signaling

GeneDecks TP73 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for TP73

5/50 Interacting proteins for TP73 (ENSP00000367545³ O15350^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 50 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABL1	P00519²	STRING (score=.992) MINT-3388834
EP300	Q09472²	STRING (score=.937) MINT-13681
E6 E6 (xeno)	P03126¹^,²	EBI-389623, EBI-1177242 MINT-69573 MINT-69576 MINT-69575
HMGB1	P09429¹	EBI-389606, EBI-389432
Cables1 Cables1 (xeno)	Q9ESJ1¹	EBI-389606, EBI-604411

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002347	response to tumor cell	IEA	--
GO:0006298	mismatch repair	TAS	10391249
GO:0006915	apoptosis	IEA	--
GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis	TAS	10391251
GO:0030308	negative regulation of cell growth	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TP73
10/12 Novoseek chemical compound relationships for TP73 gene (see all 12 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
noxa	60.60	11	15572378 (2), 16899408 (1), 16363065 (1), 18343378 (1) (see all 7)
o6-methylguanine	46.22	4	16231140 (1), 19347729 (1), 14654977 (1), 15197802 (1)
amino acid	25.20	1	10383137 (1)
progesterone	3.84	1	15450420 (1)
tyrosine	0.53	20	17535448 (3), 10391251 (2), 15070730 (1), 12594211 (1) (see all 9)
lipid	0.43	1	15598310 (1)
p003	0.00	2	16750334 (1), 12928725 (1)
oligonucleotide	0.00	1	16343436 (1)
p002	0.00	3	16750334 (1), 12928725 (1)
threonine	0.00	2	11840343 (1), 17521288 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TP73)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TP73)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001126240

Sigma-Aldrich siRNA for TP73

Sigma-Aldrich shRNA Panels and shRNA for TP73

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001126240 NM_001126241 NM_001126242 NM_005427

REFSEQ mRNAs for TP73 gene (4 alternative transcripts):

NM_001126240.1 NM_001126241.1 NM_001126242.1 NM_005427.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001126240 NM_001126241 NM_001126242 NM_005427

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001126240
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001126240
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001126240

Additional cDNA sequence:

AB055065.1 AB055066.1 AK295669.1 AK302118.1 AK304177.1 AK304784.1 AK310432.1 AY040827.1

AY040828.1 AY040829.1 BC117251.1 BC117253.1 CR599961.1 Y11416.1

8 DOTS entries:

DT.100748937 DT.406070 DT.95098410 DT.97824210 DT.100018189 DT.121356582 DT.121356601 DT.91967156

24/32 AceView cDNA sequences (see all 32 ):

NM_005427 CR599961 AB055066 BM471663 AA908299 AB055065 BX348733 BX349978

BX280538 AY040829 AY040827 AY040828 Y11416 AA614544 AL528847 BI087031

BQ669420 BX108274 BF304617 BE295836 BI092821 AW503182 AA936771 CF137367

highest scoring ESTs for TP73:

AA936771 AB055065 AB055066 AY040827 AY040828 AY040829 BF813649 BG210348 BI017128 BI087031

Unigene Cluster for TP73:

Tumor protein p73

Hs.697294 [show with all ESTs]

Unigene Representative Sequence: NM_005427

GeneLoc Exon Structure

8 Ensembl transcripts including schematic representations:

ENST00000378280 ENST00000378285 ENST00000378288 ENST00000378290 ENST00000354437 ENST00000378295

ENST00000357733 ENST00000346387

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TP73 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TP73

¹ / ² / ³

5 probe-sets matching TP73 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
232546_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
220804_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005427	0.60	1.00	0.82	1
1554379_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
232546_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
220804_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGGTACCGCC

SOURCE GeneReport for Unigene cluster: Hs.697294
UniProtKB/Swiss-Prot: P73_HUMAN, O15350
Tissue specificity: Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle,
prostate, thymus and pancreas. Highly expressed in fetal tissue

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TP73 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TP73¹	--	tumor protein p73	88.59(n) 90.69(a)	489620 XM_546740.2 XP_546740.2
cow (Bos taurus)	TP73¹	--	tumor protein p73	88.95(n) 91.32(a)	515105 XM_593064.3 XP_593064.3
rat (Rattus norvegicus)	Tp73¹	--	tumor protein p73	87.08(n) 93.27(a)	362675 XM_342992.3 XP_342993.3
mouse (Mus musculus)	Trp73^{1, 5}	4 (82.00 cM)⁵	transformation related protein 73^{1, 5}	85.93(n)¹ 90.85(a)¹	22062¹ NM_011642.2¹ NP_035772.1¹ AA437666⁵ AB221594⁵ (see all 15)
chicken (Gallus gallus)	TP73¹	--	tumor protein p73	79.85(n) 83.25(a)	419382 XM_417545.2 XP_417545.2

About this table Species with no ortholog for TP73

ENSEMBL Gene Tree for TP73

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TP73 gene

TP63² TP53²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/578 NCBI SNPs in TP73 are shown (see all 578 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 232)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs9662633^1,2	A,F,H	3639422(+)	`TGGGCG/AGACTT`	4	A/A	syn¹ ut3¹ ese³		4		EU EA WA	392
	rs2273953^1,2	C,F	3588760(-)	`CAGCTC/TRCTCT`	1	--	ut5¹		5		MN CSAM EA	404
	rs1801173^1,2	C,F	3588770(+)	`GCCCTC/TGGAGG`	1	--	ut5¹ ese³		5		MN CSAM EA	404
	rs3765729^1,2	F	3597215(+)	`CGCTCG/AGTCCA`	4	--	int¹ ut5¹ ese³		1		EA	1470
--	rs5031052^1,2	F	3588759(+)	`CAGAGC/TRAGCT`	1	--	ut5¹		5		MN CSAM EA	404
--	rs9659687^1,2	A	3639654(+)	`CTCACA/CGGCCC`	4	--	ut3¹ ese³		0	--	--	--	--
--	rs9659688^1,2	A	3639665(+)	`CAGGAA/GAGGCC`	4	--	ut3¹		0	--	--	--	--
--	rs1801174^1,2	A,C,F	3628534(+)	`GGCACT/CGCCAT`	4	T/T	syn¹		4		EA NA	1634
	rs12048341^1,2	F	3634614(+)	`CGGCAT/CGGAGA`	4	H/H	syn¹		1		NA	65
	rs2146658^1,2	A,C,F,H,O	3627473(-)	`CCCCAC/AAGGGC`	1	--	int¹		7		EA WA NA	505

About this table

HapMap Linkage Disequilibrium images for TP73 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601990

UniProtKB/Swiss-Prot: P73_HUMAN, O15350

Maps to a chromosome region frequently mutated in diverse cell lines of human cancer.

Appears not to be frequently mutated in human cancers, in contrast to p53. Hemizygosity is

observed in neuroblastoma and oligodendroglioma

10/94 Novoseek disease relationships for TP73 gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	72.06	541	14719122 (6), 10773878 (6), 10341287 (6), 16007185 (5) (see all 99)
cancer	63.15	159	11139314 (4), 18583938 (3), 18406616 (3), 10362363 (3) (see all 99)
allelic loss	61.66	19	11510689 (1), 11301342 (1), 10023682 (1), 10371354 (1) (see all 15)
oligodendroglial tumors	56.47	9	11920588 (5), 12241107 (1), 11487055 (1)
carcinoma squamous cell	48.75	23	10753204 (2), 17699776 (2), 15180941 (2), 15390192 (2) (see all 17)
oligodendroglioma	47.72	14	10953317 (3), 9721206 (3), 10732753 (1), 12200621 (1) (see all 5)
plasma cell leukemia	39.01	1	10602435 (1)
promyelocytic leukemia	37.29	4	19111660 (1), 11559539 (1), 15184504 (1), 15893728 (1)
somatic mutations	37.11	5	10218465 (1), 11301342 (1), 10404074 (1), 9537234 (1) (see all 5)
retinoblastoma	36.47	8	18619959 (4), 12584188 (1), 11709051 (1), 17045206 (1) (see all 5)

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Human Gene Mutation Database: TP73
Genetic Association Database: TP73
Human Genome Epidemiology Navigator: TP73 (28 documents)
Tumor Gene Database: TP73

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/689 PubMed articles for TP73 gene (see all 689 ):

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. (PubMed id 9288759)^{1, 2, 3, 4} Kaghad M....Caput D. (1997)
A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity. (PubMed id 12890487)^{1, 3, 4} Miyazaki K....Nakagawara A. (2003)
Two new p73 splice variants, gamma and delta, with different transcriptional activity. (PubMed id 9802988)^{1, 3, 4} De Laurenzi V.... Melino G. (1998)
Mutational analysis of p73 and p53 in human cancer cell lines. (PubMed id 10362363)^{1, 3, 4} Yoshikawa H....Harris C.C. (1999)
The emerging p53 gene family. (PubMed id 10203277)^{1, 3, 4} Kaelin W.G. Jr. (1999)
[Association of two genetic polymorphisms in the 5'untranslated region of exon 2 of the p73 gene and risk of lung cancer] (PubMed id 15921610)^{1, 3, 6} Hu Z.B....Shen H.B. (2005)
Dinucleotide polymorphism of p73 gene is associated with a reduced risk of lung cancer in a Chinese population. (PubMed id 15578704)^{1, 3, 6} Hu Z....Shen H. (2005)
Differential effect of ik3-1/cables on p53- and p73-induced cell death. (PubMed id 11706030)^{1, 3, 4} Tsuji K.... Matsuoka M. (2002)
Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain. (PubMed id 10449409)^{1, 3, 4} Chi S.W.... Arrowsmith C.H. (1999)
p73 G4C14-to-A4T14 polymorphism and risk of lung cancer. (PubMed id 15466174)^{1, 3, 6} Li G....Wei Q. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7161	HGNC: 12003	AceView: TP73	Ensembl:ENSG00000078900	euGenes: HUgn7161
ECgene: TP73	H-InvDB: TP73

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TP73	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for TP73
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TP73:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TP73-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TP73		Antibodies for TP73
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TP73		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Antibodies (TP73)
	Chimera RNAi (TP73)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (p73 Delta N, p73 alpha, p73, p73 alpha+beta, p73 beta)
	Antibodies (p73 Delta N, p73 alpha, p73, p73 alpha+beta, p73 beta)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for TP73

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TP73

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
TP73 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

TP73 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for TP73

Summaries
for TP73

Genomic Location
for TP73

Proteins
for TP73

Protein Domains/
Families
for TP73

Gene Function
for TP73

Pathways & Interactions
for TP73

Drugs & Compounds
for TP73

Transcripts
for TP73

Expression
for TP73

Orthologs
for TP73

Paralogs
for TP73

SNPs/Variants
for TP73

Disorders & Mutations
for TP73

Medical News
for TP73

Publications
for TP73

Search for TP73

Genome Databases showing TP73

Other Databases showing TP73

Specialized Databases showing TP73

Licensable Technologies
for TP73

Services
for TP73

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TP73 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor TP73

Summariesfor TP73

Genomic Locationfor TP73

Proteinsfor TP73

Protein Domains/Familiesfor TP73

Gene Functionfor TP73

Pathways & Interactionsfor TP73

Drugs & Compoundsfor TP73

Transcriptsfor TP73

Expression for TP73

Orthologsfor TP73

Paralogsfor TP73

SNPs/Variantsfor TP73

Disorders & Mutationsfor TP73

Medical Newsfor TP73

Publicationsfor TP73

Search for TP73

Genome Databases showing TP73

Other Databases showing TP73

Specialized Databases showing TP73

Licensable Technologiesfor TP73

Servicesfor TP73

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TP73

Summaries
for TP73

Genomic Location
for TP73

Proteins
for TP73

Protein Domains/
Families
for TP73

Gene Function
for TP73

Pathways & Interactions
for TP73

Drugs & Compounds
for TP73

Transcripts
for TP73

Expression
for TP73

Orthologs
for TP73

Paralogs
for TP73

SNPs/Variants
for TP73

Disorders & Mutations
for TP73

Medical News
for TP73

Publications
for TP73

Licensable Technologies
for TP73

Services
for TP73