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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TP73 Gene

protein-coding   GIFtS: 65
GCID: GC01P003592

tumor protein p73
 Explore 121 diseases affiliated with
TP73 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TP73    

Aliases
for TP73 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tumor Protein P731 2
P731 2 3
P53-Like Transcription Factor2 3
P53-Related Protein2 3

External Ids:    HGNC: 120031   Entrez Gene: 71612   Ensembl: ENSG000000789007   OMIM: 6019905   UniProtKB: O153503   

Export aliases for TP73 gene to outside databases

Previous GC identifers: GC01P003007 GC01P003526 GC01P003142 GC01P003352 GC01P003283 GC01P002864


Summaries
for TP73 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TP73:
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and
development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and
thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed
(likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript
variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the
biological validity and the full-length nature of some variants have not been determined. (provided by RefSeq, Feb
2011)

UniProtKB/Swiss-Prot: P73_HUMAN, O15350
Function: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are
pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73
isoforms. May be a tumor suppressor protein

Gene Wiki entry for TP73 (P73)


Genomic Views
for TP73 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004350.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TP73 gene promoter:
         AREB6   p53   Egr-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TP73 promoter sequence
   Search SABiosciences Chromatin IP Primers for TP73

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP73


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.3   Ensembl cytogenetic band:  1p36.32   HGNC cytogenetic band: 1p36.3

TP73 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP73 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P003592:  view genomic region     (about GC identifiers)

Start:
 3,569,084 bp from pter      End:
 3,652,765 bp from pter
Size:
 83,682 bases      Orientation:
 plus strand

Proteins
for TP73 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: P73_HUMAN, O15350 (See protein sequence)
Recommended Name: Tumor protein p73  
Size: 636 amino acids; 69623 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Found in a complex with p53/TP53 and CABLES1. The C-terminal oligomerization domain binds to the ABL1 tyrosine
kinase SH3 domain. Interacts with HECW2. Isoform Beta interacts homotypically and with p53/TP53, whereas isoform Alpha
does not. Isoform Gamma interacts homotypically and with all p73 isoforms. Isoform Delta interacts with isoform Gamma,
isoform Alpha, and homotypically. Isoforms Alpha and Beta interact with HIPK2. Isoform Alpha interacts with RANBP9.
Isoform Beta interacts with WWOX. Interacts (via SAM domain) with FBXO45 (via B30.2/SPRY domain). Interacts with YAP1
(phosphorylated form). Interacts with HCK (via SH3 domain); this inhibits TP73 activity and degradation
Subcellular location: Nucleus. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage
Miscellaneous: Maps to a chromosome region frequently mutated in diverse cell lines of human cancer. Appears not to be
frequently mutated in human cancers, in contrast to p53/TP53. Hemizygosity is observed in neuroblastoma and
oligodendroglioma
Miscellaneous: Activated and stabilized by interaction with RANBP9
6/13 PDB 3D structures from and Proteopedia for TP73 (see all 13):
1COK (3D)        1DXS (3D)        2KBY (3D)        2WQI (3D)        2WQJ (3D)        2WTT (3D)    
Secondary accessions: B7Z7J4 B7Z9C1 O15351 Q17RN8 Q5TBV5 Q5TBV6 Q8NHW9 Q8TDY5 Q8TDY6 Q9NTK8
Alternative promoter usage, Alternative splicing: 10 isoforms:  O15350-1   O15350-2   O15350-3   O15350-4   O15350-5   O15350-6   O15350-8   O15350-9   
O15350-10   O15350-11   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TP73: NX_O15350

Post-translational modifications:

  • Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not
    • affect transcriptional activity. Phosphorylation by PLK1 and PLK3 inhibits the transcription regulator activity and
    pro-apoptotic function1
  • Higher levels of phosphorylation seen in the brain from patients with Huntington disease1
  • Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15350

    • TP73 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (13 alternative transcripts): 
    NP_001119712.1  NP_001119713.1  NP_001119714.1  NP_001191113.1  NP_001191114.1  NP_001191115.1  NP_001191116.1  NP_001191117.1  
    NP_001191118.1  NP_001191119.1  NP_001191120.1  NP_001191121.1  NP_005418.1  

    ENSEMBL proteins: 
     ENSP00000367545   ENSP00000346423   ENSP00000367534   ENSP00000367529   ENSP00000367537  
     ENSP00000350366   ENSP00000340740   ENSP00000367539  

    Human Recombinant Protein Products: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: TP73
    OriGene Protein Over-expression Lysate (see all 2): TP73
    OriGene Custom Protein Services for TP73 
    GenScript Custom Purified and Recombinant Proteins Services for TP73
    Novus Biologicals TP73 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TP73

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IBA--
    GO:0005634nucleus IDA19490146
    GO:0005667transcription factor complex IBA--
    GO:0005829cytosol IBA--


    TP73 for ontologies           About GeneDecksing



    TP73 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TP73
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for TP73  (p73)
    OriGene Antibodies (see all 4): TP73
    OriGene Custom Antibody Services for TP73 
    GenScript Custom Superior Antibodies Services for TP73
    Novus Biologicals TP73 Antibodies
    Abcam antibodies for TP73 
    Uscn Antibodies for TP73
    ThermoFisher Antibodies for TP73

    Assay Products for TP73: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TP73
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    Uscn ELISAs and CLIAs for TP73

    Protein Domains /
    Families
    for TP73 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TP73 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR011615 p53_DNA-bd
     IPR012346 p53/RUNT-type_TF_DNA-bd
     IPR002117 p53_tumour_suppressor
     IPR013761 SAM/pointed
     IPR008967 p53-like_TF_DNA-bd

    Graphical View of Domain Structure for InterPro Entry O15350

    ProtoNet protein and cluster: O15350

    3 Blocks protein families:
    IPB001660 Sterile alpha motif SAM
    IPB010991 p53
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: P73_HUMAN, O15350
    Domain: Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization
    domain that binds to the ABL1 tyrosine kinase SH3 domain
    Domain: The WW-binding motif mediates interaction with WWOX
    Similarity: Belongs to the p53 family
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Function
    for TP73 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: P73_HUMAN, O15350
    Function: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are
    pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73
    isoforms. May be a tumor suppressor protein
    Induction: Not induced by DNA damage. Isoforms lacking the transactivation domain block gene induction

         Genatlas biochemistry entry for TP73:
    tumor protein 73,with two alternatively spliced isoforms,alpha and beta,activating transcription of p53-responsive
    genes and inhibiting cell growth by inducing apoptosis,also target of ABL1 (c-ABL) in response to DNA damage in a
    mismatch repair-dependent apoptosis,monoallelicaly expressed (?,paternally imprinted),frequently deleted in
    neuroblastoma in advanced stage but unlikely to be a suppressor gene in neuroblastoma,and other tumors (see TSG1A)
    (not in oligodendrogliomas,in colorectal or in oesophageal carcinomas),overexpressed in bladder carcinoma

    miRNA
    Products:            		miRTarBase miRNAs that target TP73:
    hsa-mir-193a-5p (MIRT005603)

    OriGene 3'-UTR Clone (see all 4): TP73
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TP73
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate TP73 (see all 41):
    hsa-miR-323-3p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-429 hsa-miR-106a hsa-miR-449a hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmid: TP73 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TP73 (see all 4)
    OriGene shRNA RFP: TP73
    OriGene siRNA: TP73
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TP73

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TP73

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TP73 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP73 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 13): TP73 (NM_001204186)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TP73
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP73 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TP73
    Search LifeMap BioReagents cell lines for TP73

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP73

    Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IBA--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IBA--
    GO:0003684damaged DNA binding IBA--
    GO:0003690double-stranded DNA binding IBA--


    TP73 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Trp73tm1Fmc for TP73
         15/20 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Trp73) (see all 20):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  nervous system  other 

    TP73 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TP73 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_Notch Signaling Pathway
    		Development_Notch Signaling Pathway1.00
    		Development Notch Signaling Pathway0.97
    2DNA Damage
    		DNA Damage1.00
    3Cell Cycle / Checkpoint Control
    		Cell Cycle / Checkpoint Control1.00
    4ATM Pathway
    		ATM Pathway1.00
    514-3-3 and Regulation of BAD Activity
    		14-3-3 and Regulation of BAD Activity1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TP73
        Development Notch Signaling Pathway

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TP73
        ATM Pathway
    14-3-3 and Regulation of BAD Activity
    14-3-3 Induced Intracellular Signaling

    2 Cell Signaling Technology (CST) Pathways for TP73
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 GeneGo (Thomson Reuters) Pathway for TP73
        Development Notch Signaling Pathway

    5/8 BioSystems Pathways for TP73 (see all 8) 
        TP53 network
    Apoptosis
    SIDS Susceptibility Pathways
    DNA damage response (only ATM dependent)
    TGF-beta Receptor Signaling Pathway


    3         Kegg Pathways  (Kegg details for TP73):
        p53 signaling pathway
    Neurotrophin signaling pathway
    Measles


    TP73 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TP73

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/134 Interacting proteins for TP73 (O153501, 2, 3 ENSP000003675454) via UniProtKB, MINT, STRING, and/or I2D (see all 134)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITCHQ96J022, 3, ENSP000003639984MINT-3389196 MINT-3389321 MINT-3389044 MINT-3389118 MINT-3389173 MINT-3389070 MINT-3389148 MINT-3389300 I2D: score=4 STRING: ENSP00000363998
    WWOXQ9NZC72, 3, ENSP000003861614MINT-60129 MINT-60098 MINT-60104 MINT-60132 MINT-60099 MINT-60101 MINT-60131 MINT-60106 MINT-60103 MINT-60130 MINT-60102 MINT-60128 MINT-60105 MINT-60100 I2D: score=2 STRING: ENSP00000386161
    HIST1H4LP628053, ENSP000003482584I2D: score=1 STRING: ENSP00000348258
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IBA--
    GO:0000187activation of MAPK activity IEA--
    GO:0001822kidney development IEA--
    GO:0001836release of cytochrome c from mitochondria IEA--
    GO:0006298mismatch repair TAS10391249


    TP73 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TP73 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TP73 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TP73
    10/33 Novoseek chemical compound relationships for TP73 gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    noxa 63 19 20195489 (3), 20160496 (2), 15572378 (2), 16899408 (1) (see all 9)
    cisplatin 56 94 16815295 (6), 16135520 (5), 16526280 (5), 16773194 (4) (see all 39)
    o6-methylguanine 44.4 4 16231140 (1), 19347729 (1), 14654977 (1), 15197802 (1)
    dmso 44 23 17287142 (2), 15805112 (1), 11423969 (1), 16630058 (1) (see all 16)
    5-aza-2'deoxycytidine 42.8 7 15015578 (3), 15609309 (1), 14733783 (1), 16193303 (1)
    adriamycin 31.1 26 11269743 (5), 19523927 (2), 15849742 (2), 15678153 (1) (see all 8)
    amino acid 23.3 1 10383137 (1)
    doxorubicin 8.51 4 19082486 (1), 16631755 (1), 17363502 (1)
    imatinib 8.2 7 18559370 (3), 16741250 (2)
    fatty acid 5.23 1 19517019 (1)

    Search CenterWatch for drugs/clinical trials and news about TP73 / P73 

    Transcripts
    for TP73 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TP73 gene (13 alternative transcripts): 
    NM_001126240.2  NM_001126241.2  NM_001126242.2  NM_001204184.1  NM_001204185.1  NM_001204186.1  NM_001204187.1  NM_001204188.1  
    NM_001204189.1  NM_001204190.1  NM_001204191.1  NM_001204192.1  NM_005427.3  

    Unigene Cluster for TP73:

    Tumor protein p73
    Hs.192132  [show with all ESTs]
    Unigene Representative Sequence: NM_005427
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378295(uc001akp.3 uc021ofb.1 uc021ofc.1 uc021ofd.1 uc021ofe.1 uc021off.1)
    ENST00000354437 ENST00000378285 ENST00000378280(uc010nzj.2) ENST00000378288(uc021ofg.1 uc021ofh.1 uc021ofi.1 uc001akr.3 uc009vlk.2 uc001aks.3 uc010nzk.2 uc010nzl.2)
    ENST00000357733 ENST00000346387 ENST00000378290(uc009vll.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TP73
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate TP73 (see all 41):
    hsa-miR-323-3p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-429 hsa-miR-106a hsa-miR-449a hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmid: TP73 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TP73 (see all 4)
    OriGene shRNA RFP: TP73
    OriGene siRNA: TP73
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TP73
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 13): TP73 (NM_001204186)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TP73
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP73 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TP73
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TP73
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP73

    Additional cDNA sequence: 

    AB055065.1 AB055066.1 AK295669.1 AK302118.1 AK304177.1 AK304784.1 AK310432.1 AY040827.1 
    AY040828.1 AY040829.1 BC117251.1 BC117253.1 Y11416.1 

    9 DOTS entries:

    DT.100748937  DT.100680877  DT.406070  DT.95098410  DT.97824210  DT.100018189  DT.121356582  DT.121356601 
    DT.91967156 

    24/32 AceView cDNA sequences (see all 32):

    BM471663 Y11416 AY040829 AY040827 BX280538 CR599961 AB055065 NM_005427 
    AB055066 BX349978 BX348733 AY040828 AA908299 BF304617 BI092821 AA614544 
    AL528847 BX108274 BI087031 BE295836 BQ669420 AL563268 CF137367 BF303874 

    GeneLoc Exon Structure


    Expression
    for TP73 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TP73 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGTACCGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TP73 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainChoroid PlexusChoroid Plexus Progenitor CellsChoroid Plexus
    BrainChoroid PlexusMature Choroid Plexus CellsChoroid Plexus
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TP73 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TP73

    SOURCE GeneReport for Unigene cluster: Hs.192132

    UniProtKB/Swiss-Prot: P73_HUMAN, O15350
    Tissue specificity: Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain,
    kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in
    fetal tissue

        SABiosciences Expression via Pathway-Focused PCR Arrays including TP73 (see all 6): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Breast Cancer in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    Orthologs
    for TP73 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TP73 gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TP731 tumor protein p73 79.9(n)
    83.25(a)    		   419382  XM_417545.2  XP_417545.2 
    lizard
    (Anolis carolinensis)    		 Reptilia TP736
    		 --
    		 81(a)
    		 1 ↔ 1
    		 GL344123.1(37057-70845)
    zebrafish
    (Danio rerio)    		 Actinopterygii tp732 tumor protein p73 75.59(n)   368221  AY365192.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta p536
    		 p53
    		 14(a)
    		 possible ortholog
    		 3R(18875379-18879804)


    ENSEMBL Gene Tree for TP73 (if available)
    TreeFam Gene Tree for TP73 (if available) 

    Paralogs
    for TP73 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TP73 gene
    TP532  TP632  
    3 SIMAP similar genes for TP73 using alignment to 3 protein entries:     P73_HUMAN (see all proteins):
    p53    TP63    TP53

    TP73 for paralogs           About GeneDecksing



    Genomic Variants
    for TP73 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1833 NCBI SNPs in TP73 are shown (see all 1833)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1160358421,2
    		C,F,--2871030(+) ATGGCA/GTNNNN 1 -- int11Minor allele frequency- G:0.03NA 120
    rs1163075111,2
    		F,--3567140(+) CGTGTA/GTGTAA 7 -- us2k11Minor allele frequency- G:0.03NA 120
    rs1876547101,2
    		--3567306(+) CGCGGC/GCACCG 7 -- us2k10--------
    rs776090571,2
    		F,--3567561(+) TAGGGC/GCCCCC 7 -- us2k11Minor allele frequency- G:0.06WA 118
    rs1921909851,2
    		--3567630(+) CCAGGC/GTCCTG 7 -- us2k10--------
    rs1847966561,2
    		--3567862(+) CCTCCC/TCGTCA 7 -- us2k10--------
    rs791423951,2
    		--3567987(+) ACATCC/GGTTCG 7 -- us2k10--------
    rs1159993691,2
    		--3568037(+) AGCGCC/TGCCAC 7 -- us2k11Minor allele frequency- T:0.01WA 118
    rs10046501,2
    		C,F,A,H,--3568162(-) AGCGAC/AACCCG 7 -- us2k115Minor allele frequency- A:0.11NS EA NA 2848
    rs1510174711,2
    		--3568263(+) AACACA/CGAACG 7 -- us2k10--------

    HapMap Linkage Disequilibrium report for TP73 (3569084 - 3652765 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for TP73
         2 CNVs: 4197 2296
         1 Indel: 24194
    Human Gene Mutation Database (HGMD): TP73

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing TP73:
    Pancreatic Cancer
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TP73
    DNA2.0 Custom Variant and Variant Library Synthesis for TP73

    Disorders / Diseases
    for TP73 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TP73 for disorders           About GeneDecksing

    OMIM gene information: 601990    OMIM disorders: --

    20/121 diseases for TP73 (see all 121):    About MalaCards
    monoclonal gammopathy of undetermined significance    neuroblastoma    xeroderma pigmentosum, group c    eccrine porocarcinoma
    peutz-jeghers syndrome    cleft lip/palate    cervical intraepithelial neoplasia    squamous cell carcinoma
    xeroderma pigmentosum    non-small cell lung carcinoma    plasma cell leukemia    laryngeal squamous cell carcinoma
    neurofibrosarcoma    pilocytic astrocytoma    cleft lip    cervical squamous cell carcinoma
    bile duct carcinoma    non-hodgkin lymphoma    ependymoblastoma    gastrointestinal stromal tumor

    1 disease from the University of Copenhagen DISEASES database for TP73:
    Cancer

    10/94 Novoseek disease relationships for TP73 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 72.1 594 14719122 (6), 10773878 (6), 10341287 (6), 16007185 (5) (see all 99)
    cancer 64 179 11139314 (4), 19754415 (3), 18583938 (3), 10362363 (3) (see all 99)
    allelic loss 60.4 19 11510689 (1), 11301342 (1), 10023682 (1), 10371354 (1) (see all 15)
    oligodendroglial tumors 54 9 11920588 (5), 12241107 (1), 11487055 (1)
    carcinoma squamous cell 51.8 25 10753204 (2), 17699776 (2), 15180941 (2), 15390192 (2) (see all 19)
    oligodendroglioma 45.6 14 10953317 (3), 9721206 (3), 10732753 (1), 12200621 (1) (see all 5)
    retinoblastoma 38.4 9 18619959 (4), 12584188 (1), 11709051 (1), 19643581 (1) (see all 6)
    plasma cell leukemia 36.9 1 10602435 (1)
    primary tumor 36.5 21 16750334 (4), 10935473 (1), 11859406 (1), 14760085 (1) (see all 12)
    promyelocytic leukemia 35.2 4 19111660 (1), 11559539 (1), 15184504 (1), 15893728 (1)

    Genetic Association Database (GAD): TP73
    Human Genome Epidemiology (HuGE) Navigator: TP73 (44 documents)
    Tumor Gene Database (TGDB): TP73

    Export disorders for TP73 gene to outside databases

    Publications
    for TP73 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TP73 gene, integrated from 9 sources (see all 874):
    (articles sorted by number of sources associating them with TP73)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. (PubMed id 9288759)1, 2, 3, 9 Kaghad M....Caput D. (1997)
    2. Plk3 inhibits pro-apoptotic activity of p73 through p hysical interaction and phosphorylation. (PubMed id 19490146)1, 2, 9 Sang M....Ozaki T. (2009)
    3. A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity. (PubMed id 12890487)1, 2, 9 Miyazaki K....Nakagawara A. (2003)
    4. Mutational analysis of p73 and p53 in human cancer cell lines. (PubMed id 10362363)1, 2, 9 Yoshikawa H....Harris C.C. (1999)
    5. The emerging p53 gene family. (PubMed id 10203277)1, 2, 9 Kaelin W.G. Jr. (1999)
    6. [Association of two genetic polymorphisms in the 5'untranslated region of exon 2 of the p73 gene and risk of lung cancer] (PubMed id 15921610)1, 4, 9 Hu Z.B....Shen H.B. (2005)
    7. Dinucleotide polymorphism of p73 gene is associated with a reduced risk of lung cancer in a Chinese population. (PubMed id 15578704)1, 4, 9 Hu Z....Shen H. (2005)
    8. Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain. (PubMed id 10449409)1, 2, 9 Chi S.W.... Arrowsmith C.H. (1999)
    9. Genomic organization and mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-arm deletions. (PubMed id 9721206)1, 2, 9 Mai M.... Liu W. (1998)
    10. Two new p73 splice variants, gamma and delta, with different transcriptional activity. (PubMed id 9802988)1, 2, 9 De Laurenzi V.... Melino G. (1998)

    External Searches for TP73 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TP73 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7161 HGNC: 12003 AceView: TP73 Ensembl:ENSG00000078900 euGenes: HUgn7161
    ECgene: TP73 Kegg: 7161 H-InvDB: TP73

    Other Databases showing TP73 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TP73 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TP73 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TP73 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TP73 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TP73 gene:
    Search GeneIP for patents involving TP73

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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