Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TP73 Gene

protein-coding   GIFtS: 64
GCID: GC01P003592

Tumor Protein P73

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Protein P731 2
P732 3
P53-Like Transcription Factor2 3
P53-Related Protein2 3

External Ids:    HGNC: 120031   Entrez Gene: 71612   Ensembl: ENSG000000789007   OMIM: 6019905   UniProtKB: O153503   

Export aliases for TP73 gene to outside databases

Previous GC identifers: GC01P003007 GC01P003526 GC01P003142 GC01P003352 GC01P003283 GC01P002864


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TP73 Gene:
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and
development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors,
and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically
expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma.
Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found
for this gene, but the biological validity and the full-length nature of some variants have not been determined.
(provided by RefSeq, Feb 2011)

GeneCards Summary for TP73 Gene: 
TP73 (tumor protein p73) is a protein-coding gene. Diseases associated with TP73 include neurofibrosarcoma, and tetraploidy, and among its related super-pathways are Cell Cycle / Checkpoint Control and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include identical protein binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TP53.

UniProtKB/Swiss-Prot: P73_HUMAN, O15350
Function: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are
pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating
p73 isoforms. May be a tumor suppressor protein

Gene Wiki entry for TP73 (P73) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004350.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TP73 gene promoter:
         AREB6   p53   Egr-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TP73 promoter sequence
   Search SABiosciences Chromatin IP Primers for TP73

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP73


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.3   Ensembl cytogenetic band:  1p36.32   HGNC cytogenetic band: 1p36.3

TP73 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP73 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P003592:  view genomic region     (about GC identifiers)

Start:
3,569,084 bp from pter      End:
3,652,765 bp from pter
Size:
83,682 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: P73_HUMAN, O15350 (See protein sequence)
Recommended Name: Tumor protein p73  
Size: 636 amino acids; 69623 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Found in a complex with p53/TP53 and CABLES1. The C-terminal oligomerization domain binds to the ABL1
tyrosine kinase SH3 domain. Interacts with HECW2. Isoform Beta interacts homotypically and with p53/TP53, whereas
isoform Alpha does not. Isoform Gamma interacts homotypically and with all p73 isoforms. Isoform Delta interacts
with isoform Gamma, isoform Alpha, and homotypically. Isoforms Alpha and Beta interact with HIPK2. Isoform Alpha
interacts with RANBP9. Isoform Beta interacts with WWOX. Interacts (via SAM domain) with FBXO45 (via B30.2/SPRY
domain). Interacts with YAP1 (phosphorylated form). Interacts with HCK (via SH3 domain); this inhibits TP73
activity and degradation
Subcellular location: Nucleus. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage
Miscellaneous: Maps to a chromosome region frequently mutated in diverse cell lines of human cancer. Appears not
to be frequently mutated in human cancers, in contrast to p53/TP53. Hemizygosity is observed in neuroblastoma and
oligodendroglioma
Miscellaneous: Activated and stabilized by interaction with RANBP9
6/13 PDB 3D structures from and Proteopedia for TP73 (see all 13):
1COK (3D)        1DXS (3D)        2KBY (3D)        2WQI (3D)        2WQJ (3D)        2WTT (3D)    
Secondary accessions: B7Z7J4 B7Z9C1 O15351 Q17RN8 Q5TBV5 Q5TBV6 Q8NHW9 Q8TDY5 Q8TDY6 Q9NTK8
Alternative promoter usage, Alternative splicing: 10 isoforms:  O15350-1   O15350-2   O15350-3   O15350-4   O15350-5   O15350-6   O15350-8   O15350-9   
O15350-10   O15350-11   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TP73: NX_O15350

Explore proteomics data for TP73 at MOPED 

Post-translational modifications:

  • UniProtKB: Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does
    not affect transcriptional activity. Phosphorylation by PLK1 and PLK3 inhibits the transcription regulator
    activity and pro-apoptotic function
  • UniProtKB: Higher levels of phosphorylation seen in the brain from patients with Huntington disease
  • UniProtKB: Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15350

  • TP73 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TP73 Protein Expression
    REFSEQ proteins (13 alternative transcripts): 
    NP_001119712.1  NP_001119713.1  NP_001119714.1  NP_001191113.1  NP_001191114.1  NP_001191115.1  NP_001191116.1  NP_001191117.1  
    NP_001191118.1  NP_001191119.1  NP_001191120.1  NP_001191121.1  NP_005418.1  

    ENSEMBL proteins: 
     ENSP00000367545   ENSP00000475143   ENSP00000346423   ENSP00000474626   ENSP00000474322  
     ENSP00000367534   ENSP00000367529   ENSP00000367537   ENSP00000367539   ENSP00000350366  
     ENSP00000340740  

    Human Recombinant Protein Products for TP73: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TP73
    OriGene Protein Over-expression Lysate for TP73
    OriGene MassSpec for TP73 
    OriGene Custom Protein Services for TP73
    GenScript Custom Purified and Recombinant Proteins Services for TP73
    Novus Biologicals TP73 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TP73 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IBA--
    GO:0005634nucleus IDA19490146
    GO:0005667transcription factor complex IBA--
    GO:0005829cytosol IBA--

    TP73 for ontologies           About GeneDecksing



    TP73 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TP73
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for TP73  (p73)
    OriGene Antibodies for TP73
    OriGene Custom Antibody Services for TP73
    GenScript Custom Superior Antibodies Services for TP73
    Novus Biologicals TP73 Antibodies
    Abcam antibodies for TP73
    Cloud-Clone Corp. Antibodies for TP73 
    ThermoFisher Antibody for TP73
    LSBio Antibodies in human, mouse, rat for TP73 

    Assay Products for TP73: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TP73
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TP73
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TP73 
    Cloud-Clone Corp. CLIAs for TP73


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/8 InterPro protein domains (see all 8):
     IPR011615 p53_DNA-bd
     IPR012346 p53/RUNT-type_TF_DNA-bd
     IPR002117 p53_tumour_suppressor
     IPR013761 SAM/pointed
     IPR008967 p53-like_TF_DNA-bd

    Graphical View of Domain Structure for InterPro Entry O15350

    ProtoNet protein and cluster: O15350

    3 Blocks protein domains:
    IPB001660 Sterile alpha motif SAM
    IPB010991 p53
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: P73_HUMAN, O15350
    Domain: Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization
    domain that binds to the ABL1 tyrosine kinase SH3 domain
    Domain: The WW-binding motif mediates interaction with WWOX
    Similarity: Belongs to the p53 family
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    TP73 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P73_HUMAN, O15350
    Function: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are
    pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating
    p73 isoforms. May be a tumor suppressor protein
    Induction: Not induced by DNA damage. Isoforms lacking the transactivation domain block gene induction

         Genatlas biochemistry entry for TP73:
    tumor protein 73,with two alternatively spliced isoforms,alpha and beta,activating transcription of p53-responsive
    genes and inhibiting cell growth by inducing apoptosis,also target of ABL1 (c-ABL) in response to DNA damage in a
    mismatch repair-dependent apoptosis,monoallelicaly expressed (?,paternally imprinted),frequently deleted in
    neuroblastoma in advanced stage but unlikely to be a suppressor gene in neuroblastoma,and other tumors (see
    TSG1A) (not in oligodendrogliomas,in colorectal or in oesophageal carcinomas),overexpressed in bladder carcinoma

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IBA--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IBA--
    GO:0003684damaged DNA binding IBA--
    GO:0003690double-stranded DNA binding IBA--
         
    TP73 for ontologies           About GeneDecksing


    Phenotypes:
         15/20 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Trp73) (see all 20):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  nervous system  other 

    TP73 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Trp73tm1Fmc for TP73

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TP73 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TP73

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TP73 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TP73 

    miRNA
    Products:
        
    miRTarBase miRNAs that target TP73:
    hsa-mir-193a-5p (MIRT005603)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TP73
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate TP73 (see all 41):
    hsa-miR-323-3p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-429 hsa-miR-106a hsa-miR-449a hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidTP73 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TP73
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TP73

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TP73
    Sirion Biotech Customized adenovirus for overexpression of TP73

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TP73 (see all 25)
    OriGene ORF clones in mouse, rat for TP73
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 13): TP73 (NM_001204186)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TP73
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP73
    Sirion Biotech Customized lentivirus for stable overexpression of TP73 
                         Customized lentivirus expression plasmids for stable overexpression of TP73 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TP73
    Search LifeMap BioReagents cell lines for TP73
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP73


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TP73 About   (see all 17)                                                                                              See pathways by source

    SuperPathContained pathways About
    1DNA Damage
    DNA Damage0.32
    Cell Cycle / Checkpoint Control0.32
    2Nanog in Mammalian ESC Pluripotency
    14-3-3 Induced Intracellular Signaling0.59
    3Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development Notch Signaling Pathway0.54
    4p53 signaling pathway
    p53 signaling pathway0.41
    5Apoptosis Modulation and Signaling
    Apoptosis0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TP73
        Development Notch Signaling Pathway

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TP73
        ATM Pathway
    14-3-3 and Regulation of BAD Activity
    14-3-3 Induced Intracellular Signaling

    2 Cell Signaling Technology (CST) Pathways for TP73
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 GeneGo (Thomson Reuters) Pathway for TP73
        Development Notch Signaling Pathway

    5/8 BioSystems Pathways for TP73 (see all 8)
        Apoptosis
    DNA damage response (only ATM dependent)
    TP53 network
    SIDS Susceptibility Pathways
    TGF-beta Receptor Signaling Pathway


    4         Kegg Pathways  (Kegg details for TP73):
        p53 signaling pathway
    Hippo signaling pathway
    Neurotrophin signaling pathway
    Measles


    TP73 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TP73

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/135 Interacting proteins for TP73 (O153501, 2, 3 ENSP000003675454) via UniProtKB, MINT, STRING, and/or I2D (see all 135)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITCHQ96J022, 3, ENSP000003639984MINT-3389196 MINT-3389321 MINT-3389044 MINT-3389118 MINT-3389173 MINT-3389070 MINT-3389148 MINT-3389300 I2D: score=4 STRING: ENSP00000363998
    WWOXQ9NZC72, 3, ENSP000003861614MINT-60129 MINT-60098 MINT-60104 MINT-60132 MINT-60099 MINT-60101 MINT-60131 MINT-60106 MINT-60103 MINT-60130 MINT-60102 MINT-60128 MINT-60105 MINT-60100 I2D: score=2 STRING: ENSP00000386161
    HIST1H4LP628053, ENSP000003482584I2D: score=1 STRING: ENSP00000348258
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IBA--
    GO:0000187activation of MAPK activity IEA--
    GO:0001822kidney development IEA--
    GO:0001836release of cytochrome c from mitochondria IEA--
    GO:0006298mismatch repair TAS10391249

    TP73 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TP73 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TP73 (P73)

    10/33 Novoseek inferred chemical compound relationships for TP73 gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    noxa 63 19 20195489 (3), 20160496 (2), 15572378 (2), 16899408 (1) (see all 9)
    cisplatin 56 94 16815295 (6), 16135520 (5), 16526280 (5), 16773194 (4) (see all 39)
    o6-methylguanine 44.4 4 16231140 (1), 19347729 (1), 14654977 (1), 15197802 (1)
    dmso 44 23 17287142 (2), 15805112 (1), 11423969 (1), 16630058 (1) (see all 16)
    5-aza-2'deoxycytidine 42.8 7 15015578 (3), 15609309 (1), 14733783 (1), 16193303 (1)
    adriamycin 31.1 26 11269743 (5), 19523927 (2), 15849742 (2), 15678153 (1) (see all 8)
    amino acid 23.3 1 10383137 (1)
    doxorubicin 8.51 4 19082486 (1), 16631755 (1), 17363502 (1)
    imatinib 8.2 7 18559370 (3), 16741250 (2)
    fatty acid 5.23 1 19517019 (1)

    Search CenterWatch for drugs/clinical trials and news about TP73 / P73

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TP73 gene (13 alternative transcripts): 
    NM_001126240.2  NM_001126241.2  NM_001126242.2  NM_001204184.1  NM_001204185.1  NM_001204186.1  NM_001204187.1  NM_001204188.1  
    NM_001204189.1  NM_001204190.1  NM_001204191.1  NM_001204192.1  NM_005427.3  

    Unigene Cluster for TP73:

    Tumor protein p73
    Hs.192132  [show with all ESTs]
    Unigene Representative Sequence: NM_005427
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378295(uc001akp.3 uc021ofb.1 uc021ofc.1 uc021ofd.1 uc021ofe.1 uc021off.1)
    ENST00000604074 ENST00000354437 ENST00000603362 ENST00000604479 ENST00000378285
    ENST00000378280(uc010nzj.2) ENST00000378288(uc021ofg.1 uc021ofh.1 uc021ofi.1 uc001akr.3 uc009vlk.2 uc001aks.3 uc010nzk.2 uc010nzl.2)
    ENST00000603364 ENST00000604194 ENST00000378290(uc009vll.3) ENST00000604566
    ENST00000357733 ENST00000346387

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TP73
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate TP73 (see all 41):
    hsa-miR-323-3p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-429 hsa-miR-106a hsa-miR-449a hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidTP73 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TP73
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TP73
    Clone
    Products:
         
    OriGene clones in human, mouse for TP73 (see all 25)
    OriGene ORF clones in mouse, rat for TP73
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 13): TP73 (NM_001204186)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TP73
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP73
    Sirion Biotech Customized lentivirus for stable overexpression of TP73 
                         Customized lentivirus expression plasmids for stable overexpression of TP73 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TP73
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TP73
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TP73
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP73

    Additional mRNA sequence: 

    AB055065.1 AB055066.1 AK295669.1 AK302118.1 AK304177.1 AK304784.1 AK310432.1 AY040827.1 
    AY040828.1 AY040829.1 BC117251.1 BC117253.1 Y11416.1 

    9 DOTS entries:

    DT.100748937  DT.100680877  DT.406070  DT.95098410  DT.97824210  DT.100018189  DT.121356582  DT.121356601 
    DT.91967156 

    24/32 AceView cDNA sequences (see all 32):

    CR599961 AB055066 BX280538 AB055065 Y11416 AY040828 BX348733 AA908299 
    NM_005427 BM471663 BX349978 AY040829 AY040827 BI087031 BE295836 BQ669420 
    AA614544 BI092821 BX108274 AL528847 BF304617 BF304014 AL563268 BE798870 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TP73 expression in normal human tissues (normalized intensities)      TP73 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTACCGCC
    TP73 Expression
    About this image


    TP73 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Mature Choroid Plexus Cells Choroid Plexus
             brain/forebrain/diencephalon   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             retinal progenitor cell e16.5   
     
     Epithelium (Respiratory System)    fully expand to see all 2 entries
             bronchial epithelial cells   

    See TP73 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TP73

    SOURCE GeneReport for Unigene cluster: Hs.192132

    UniProtKB/Swiss-Prot: P73_HUMAN, O15350
    Tissue specificity: Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain,
    kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed
    in fetal tissue

        SABiosciences Expression via Pathway-Focused PCR Arrays including TP73 (see all 6): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Breast Cancer in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TP73
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TP73
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TP73
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP73
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP73

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TP73 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trp731 , 5 transformation related protein 731, 5 85.43(n)1
    89.98(a)1
      4 (83.79 cM)5
    220621  NM_011642.31  NP_035772.21 
     1540562535 
    chicken
    (Gallus gallus)
    Aves TP731 tumor protein p73 79.9(n)
    83.25(a)
      419382  XM_417545.2  XP_417545.2 
    lizard
    (Anolis carolinensis)
    Reptilia TP736
    Uncharacterized protein
    80(a)
    1 ↔ 1
    GL344123.1(32954-70924)
    zebrafish
    (Danio rerio)
    Actinopterygii tp732 tumor protein p73 75.59(n)   368221  AY365192.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta p536
    p53
    15(a)
    1 → many
    3R(18875379-18879804)


    ENSEMBL Gene Tree for TP73 (if available)
    TreeFam Gene Tree for TP73 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TP73 gene
    TP532  TP632  
    3 SIMAP similar genes for TP73 using alignment to 3 protein entries:     P73_HUMAN (see all proteins):
    p53    TP63    TP53

    TP73 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2328 SNPs in TP73 are shown (see all 2328)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1125354451,2
    C,F--3572609(+) GGTGCG/AGGCAC 6 -- int12Minor allele frequency- A:0.10CSA WA 119
    rs1160358421,2
    C,F--3575320(+) ATGGCA/GTATTT 6 -- int11Minor allele frequency- G:0.03NA 120
    rs354904531,2
    C--3575434(+) TATTTT/AGGGGT 6 -- int11Minor allele frequency- A:0.50WA 2
    rs600730911,2
    C--3575741(+) AAAAAA/-GCTAA 6 -- int11Minor allele frequency- -:0.00CSA 2
    rs57721141,2
    C,F--3575742(+) AAAAAA/-GCTAA 6 -- int1 trp32Minor allele frequency- -:0.50NA 4
    rs566664561,2
    C--3576416(+) TTTTT-/TAGTAG 6 -- int10--------
    rs30346061,2
    C--3578287(-) ATATATA/-CACAA 6 -- int11Minor allele frequency- -:0.50CSA 2
    rs1480086591,2
    C--3578287(+) TTGTG-/TATA  
            
    TATAT
    6 -- int10--------
    rs1163075111,2
    C,F--3580699(+) CGTGTA/GTGTAA 6 -- us2k11Minor allele frequency- G:0.03NA 120
    rs1132667331,2
    C--3580792(+) CTCACA/GCTCCA 6 -- us2k12Minor allele frequency- G:0.33CSA 3

    HapMap Linkage Disequilibrium report for TP73 (3569084 - 3652765 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/31 variations for TP73 (see all 31):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2729250CNV Deletion23290073
    esv1634361CNV Deletion17803354
    esv2729473CNV Deletion23290073
    esv2729584CNV Deletion23290073
    esv2729695CNV Deletion23290073
    esv2729139CNV Deletion23290073
    esv994567CNV Deletion20482838
    esv2729028CNV Deletion23290073
    esv2729361CNV Deletion23290073
    esv1032022CNV Insertion17803354


    Human Gene Mutation Database (HGMD): TP73
    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing TP73:
    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing TP73
    DNA2.0 Custom Variant and Variant Library Synthesis for TP73

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601990    OMIM disorders: --

    20/110 diseases for TP73 (see all 110):    About MalaCards
    neurofibrosarcoma    tetraploidy    eccrine porocarcinoma    ependymoblastoma
    thyroid lymphoma    epstein-barr virus-associated gastric carcinoma    plasma cell leukemia    neurofibroma
    alexia    neuroblastoma    pyogenic granuloma    xeroderma pigmentosum, group c
    cervical squamous cell carcinoma    bile duct carcinoma    cervical intraepithelial neoplasia    astrocytoma
    hereditary breast cancer    pilocytic astrocytoma    anaplastic astrocytoma    laryngeal squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for TP73:
    Cancer

    TP73 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/94 Novoseek inferred disease relationships for TP73 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 72.1 594 14719122 (6), 10773878 (6), 10341287 (6), 16007185 (5) (see all 99)
    cancer 64 179 11139314 (4), 19754415 (3), 18583938 (3), 10362363 (3) (see all 99)
    allelic loss 60.4 19 11510689 (1), 11301342 (1), 10023682 (1), 10371354 (1) (see all 15)
    oligodendroglial tumors 54 9 11920588 (5), 12241107 (1), 11487055 (1)
    carcinoma squamous cell 51.8 25 10753204 (2), 17699776 (2), 15180941 (2), 15390192 (2) (see all 19)
    oligodendroglioma 45.6 14 10953317 (3), 9721206 (3), 10732753 (1), 12200621 (1) (see all 5)
    retinoblastoma 38.4 9 18619959 (4), 12584188 (1), 11709051 (1), 19643581 (1) (see all 6)
    plasma cell leukemia 36.9 1 10602435 (1)
    primary tumor 36.5 21 16750334 (4), 10935473 (1), 11859406 (1), 14760085 (1) (see all 12)
    promyelocytic leukemia 35.2 4 19111660 (1), 11559539 (1), 15184504 (1), 15893728 (1)

    Genetic Association Database (GAD): TP73
    Human Genome Epidemiology (HuGE) Navigator: TP73 (44 documents)
    Tumor Gene Database (TGDB): TP73

    Export disorders for TP73 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TP73 gene, integrated from 9 sources (see all 896):
    (articles sorted by number of sources associating them with TP73)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. (PubMed id 9288759)1, 2, 3, 9 Kaghad M....Caput D. (1997)
    2. Plk3 inhibits pro-apoptotic activity of p73 through p hysical interaction and phosphorylation. (PubMed id 19490146)1, 2, 9 Sang M....Ozaki T. (2009)
    3. Combined effects of p73 and MDM2 polymorphisms on the risk of lung cancer. (PubMed id 17013834)1, 4, 9 Jun H.J....Park J.Y. (2007)
    4. A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity. (PubMed id 12890487)1, 2, 9 Miyazaki K....Nakagawara A. (2003)
    5. [Association of the responsiveness of advanced non-small cell lung cancer to platinum-based chemotherapy with p53 and p73 polymorphisms] (PubMed id 16750013)1, 4, 9 Yuan P....Lin D.X. (2006)
    6. Combined effects of the p53 and p73 polymorphisms on lung cancer risk. (PubMed id 16434604)1, 4, 9 Schabath M.B....Spitz M.R. (2006)
    7. A case-control study on the combined effects of p53 and p73 polymorphisms on head and neck cancer risk in an Italian population. (PubMed id 19426493)1, 4, 9 GallA- P....Boccia S. (2009)
    8. Mutational analysis of p73 and p53 in human cancer cell lines. (PubMed id 10362363)1, 2, 9 Yoshikawa H....Harris C.C. (1999)
    9. The emerging p53 gene family. (PubMed id 10203277)1, 2, 9 Kaelin W.G. Jr. (1999)
    10. Polymorphisms at p53, p73, and MDM2 loci modulate the risk of tobacco associated leukoplakia and oral cancer. (PubMed id 19204927)1, 4, 9 Misra C....Roychoudhury S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7161 HGNC: 12003 AceView: TP73 Ensembl:ENSG00000078900 euGenes: HUgn7161
    ECgene: TP73 Kegg: 7161 H-InvDB: TP73

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TP73 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TP73 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TP73 gene:
    Search GeneIP for patents involving TP73

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of TP73
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TP73   OriGene RNAi products in human, mouse, rat for TP73  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TP73  
     OriGene MassSpec something-or-other for TP73   OriGene clones in human, mouse for TP73  
     OriGene qSTAR qPCR primer pairs in human, mouse for TP73   OriGene Purified Protein for TP73  
     OriGene ORF clones in mouse, rat for TP73   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TP73   OriGene Custom Protein Services for TP73  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TP73
     QIAGEN SeqTarget long-range PCR primers for resequencing TP73
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP73
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TP73
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP73
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TP73
     GenScript Custom Purified and Recombinant Proteins Services for TP73 GenScript cDNA clones with any tag delivered in your preferred vector for TP73
     GenScript Custom Assay Services for TP73 GenScript Custom Superior Antibodies Services for TP73
     GenScript Custom overexpressing Cell Line Services for TP73 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for TP73  (p73)

     Regulatory tfbs in TP73 promoter
     Search Chromatin IP Primers for TP73
     RT2 qPCR Primer Assay in human, mouse, rat TP73
     GNC Network for TP73
     SABiosciences PCR Arrays including human, mouse, rat TP73
     Search Tocris compounds for TP73 (P73)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TP73 antibodies
     TP73 lysates
     Antibodies for TP73
     See all of Abcam's Antibodies, Kits and Proteins for TP73
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TP73
     Antibodies for TP73
     ELISAs for TP73
     CLIAs for TP73
     Search LifeMap BioReagents cell lines for TP73
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP73
     SwitchGear 3'UTR luciferase reporter plasmids for TP73
     SwitchGear Promoter luciferase reporter plasmids for TP73
     ThermoFisher Antibody for TP73
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP73
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TP73
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TP73
    Customized:
     lentivirus for stable overexpression of TP73
     lentivirus expression plasmids for stable overexpression of TP73
     adenovirus for overexpression of TP73
     LSBio Antibodies in human, mouse, rat for TP73
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TP73 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4