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TP73 Gene

protein-coding   GIFtS: 63
GCID: GC01P003592

Tumor Protein P73

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Protein P731 2
P732 3
P53-Like Transcription Factor2 3
P53-Related Protein2 3

External Ids:    HGNC: 120031   Entrez Gene: 71612   Ensembl: ENSG000000789007   OMIM: 6019905   UniProtKB: O153503   

Export aliases for TP73 gene to outside databases

Previous GC identifers: GC01P003007 GC01P003526 GC01P003142 GC01P003352 GC01P003283 GC01P002864


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TP73 Gene:
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and
development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors,
and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically
expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma.
Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found
for this gene, but the biological validity and the full-length nature of some variants have not been determined.
(provided by RefSeq, Feb 2011)

GeneCards Summary for TP73 Gene:
TP73 (tumor protein p73) is a protein-coding gene. Diseases associated with TP73 include neuroblastoma, and ependymoblastoma. GO annotations related to this gene include identical protein binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TP53.

UniProtKB/Swiss-Prot: P73_HUMAN, O15350
Function: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are
pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating
p73 isoforms. May be a tumor suppressor protein

Gene Wiki entry for TP73 (P73) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the TP73 gene promoter:
         AREB6   p53   Egr-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TP73 promoter sequence
   Search Chromatin IP Primers for TP73

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TP73


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.3   Ensembl cytogenetic band:  1p36.32   HGNC cytogenetic band: 1p36.3

TP73 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP73 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P003592:  view genomic region     (about GC identifiers)

Start:
3,569,084 bp from pter      End:
3,652,765 bp from pter
Size:
83,682 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: P73_HUMAN, O15350 (See protein sequence)
Recommended Name: Tumor protein p73  
Size: 636 amino acids; 69623 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Found in a complex with p53/TP53 and CABLES1. The C-terminal oligomerization domain binds to the ABL1
tyrosine kinase SH3 domain. Interacts with HECW2. Isoform Beta interacts homotypically and with p53/TP53, whereas
isoform Alpha does not. Isoform Gamma interacts homotypically and with all p73 isoforms. Isoform Delta interacts
with isoform Gamma, isoform Alpha, and homotypically. Isoforms Alpha and Beta interact with HIPK2. Isoform Alpha
interacts with RANBP9. Isoform Beta interacts with WWOX. Interacts (via SAM domain) with FBXO45 (via B30.2/SPRY
domain). Interacts with YAP1 (phosphorylated form). Interacts with HCK (via SH3 domain); this inhibits TP73
activity and degradation
Miscellaneous: Maps to a chromosome region frequently mutated in diverse cell lines of human cancer. Appears not
to be frequently mutated in human cancers, in contrast to p53/TP53. Hemizygosity is observed in neuroblastoma and
oligodendroglioma
Miscellaneous: Activated and stabilized by interaction with RANBP9
Selected PDB 3D structures from and Proteopedia for TP73 (see all 15):
1COK (3D)        1DXS (3D)        2KBY (3D)        2WQI (3D)        2WQJ (3D)        2WTT (3D)    
Secondary accessions: B7Z7J4 B7Z8Z1 B7Z9C1 C9J521 O15351 Q17RN8 Q5TBV5 Q5TBV6 Q8NHW9 Q8TDY5
Q8TDY6 Q9NTK8
Alternative promoter usage, Alternative splicing: 12 isoforms:  O15350-1   O15350-2   O15350-3   O15350-4   O15350-5   O15350-6   O15350-8   O15350-9   
O15350-10   O15350-11   O15350-12   O15350-13   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TP73: NX_O15350

Explore proteomics data for TP73 at MOPED

Post-translational modifications: 

  • Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does
    not affect transcriptional activity. Phosphorylation by PLK1 and PLK3 inhibits the transcription regulator
    activity and pro-apoptotic function1
  • Higher levels of phosphorylation seen in the brain from patients with Huntington disease1
  • Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TP73 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (13 alternative transcripts): 
    NP_001119712.1  NP_001119713.1  NP_001119714.1  NP_001191113.1  NP_001191114.1  NP_001191115.1  NP_001191116.1  NP_001191117.1  
    NP_001191118.1  NP_001191119.1  NP_001191120.1  NP_001191121.1  NP_005418.1  

    ENSEMBL proteins: 
     ENSP00000367545   ENSP00000475143   ENSP00000346423   ENSP00000474626   ENSP00000474322  
     ENSP00000367534   ENSP00000367529   ENSP00000367537   ENSP00000367539   ENSP00000350366  
     ENSP00000340740  

    TP73 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for TP73
    OriGene Protein Over-expression Lysate for TP73
    OriGene MassSpec for TP73
    OriGene Custom Protein Services for TP73
    GenScript Custom Purified and Recombinant Proteins Services for TP73
    Novus Biologicals TP73 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TP73

    TP73 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TP73
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for TP73  (p73)
    OriGene Antibodies for TP73
    OriGene Custom Antibody Services for TP73
    Novus Biologicals TP73 Antibodies
    Abcam antibodies for TP73
    Cloud-Clone Corp. Antibodies for TP73
    ThermoFisher Antibody for TP73
    LSBio Antibodies in human, mouse, rat for TP73

    TP73 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TP73
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TP73
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TP73
    Cloud-Clone Corp. CLIAs for TP73


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR011615 p53_DNA-bd
     IPR012346 p53/RUNT-type_TF_DNA-bd
     IPR002117 p53_tumour_suppressor
     IPR013761 SAM/pointed
     IPR008967 p53-like_TF_DNA-bd

    Graphical View of Domain Structure for InterPro Entry O15350

    ProtoNet protein and cluster: O15350

    3 Blocks protein domains:
    IPB001660 Sterile alpha motif SAM
    IPB010991 p53
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: P73_HUMAN, O15350
    Domain: Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization
    domain that binds to the ABL1 tyrosine kinase SH3 domain
    Domain: The WW-binding motif mediates interaction with WWOX
    Similarity: Belongs to the p53 family
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    TP73 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P73_HUMAN, O15350
    Function: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are
    pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating
    p73 isoforms. May be a tumor suppressor protein
    Induction: Not induced by DNA damage. Isoforms lacking the transactivation domain block gene induction

         Genatlas biochemistry entry for TP73:
    tumor protein 73,with two alternatively spliced isoforms,alpha and beta,activating transcription of p53-responsive
    genes and inhibiting cell growth by inducing apoptosis,also target of ABL1 (c-ABL) in response to DNA damage in a
    mismatch repair-dependent apoptosis,monoallelicaly expressed (?,paternally imprinted),frequently deleted in
    neuroblastoma in advanced stage but unlikely to be a suppressor gene in neuroblastoma,and other tumors (see
    TSG1A) (not in oligodendrogliomas,in colorectal or in oesophageal carcinomas),overexpressed in bladder carcinoma

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IBA--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IBA--
    GO:0003684damaged DNA binding IBA--
    GO:0003690double-stranded DNA binding IBA--
         
    TP73 for ontologies           About GeneDecksing


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 4 alleles(MGI details for Trp73) (see all 20):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  nervous system  other 

    TP73 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Trp73tm1Fmc for TP73

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TP73
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TP73

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TP73
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TP73

    miRNA
    Products:
        
    miRTarBase miRNAs that target TP73:
    hsa-mir-193a-5p (MIRT005603), hsa-mir-205-5p (MIRT006897)

    Block miRNA regulation of human, mouse, rat TP73 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TP73 (see all 41):
    hsa-miR-323-3p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-429 hsa-miR-106a hsa-miR-449a hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidTP73 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TP73
    Predesigned siRNA for gene silencing in human, mouse, rat TP73

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TP73

    Clone
    Products:
         
    OriGene clones in human, mouse for TP73 (see all 23)
    OriGene ORF clones in mouse, rat for TP73
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 13): TP73 (NM_001204186)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TP73
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP73

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TP73
    Browse ESI BIO Cell Lines and PureStem Progenitors for TP73 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP73


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    P73_HUMAN, O15350: Nucleus. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IBA--
    GO:0005634nucleus IDA19490146
    GO:0005667transcription factor complex IBA--
    GO:0005829cytosol IBA--

    TP73 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TP73 About   (see all 17)  
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    DNA Damage0.32
    2Nanog in Mammalian ESC Pluripotency
    14-3-3 Induced Intracellular Signaling0.59
    3Development NOTCH1 mediated pathway for NF KB activity modulation
    Development Notch Signaling Pathway0.50
    4p53 signaling pathway
    p53 signaling pathway0.41
    5Apoptosis (WikiPathways)
    Apoptosis0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TP73
        ATM Pathway
    14-3-3 and Regulation of BAD Activity
    14-3-3 Induced Intracellular Signaling

    2 Cell Signaling Technology (CST) Pathways for TP73
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 GeneGo (Thomson Reuters) Pathway for TP73
        Development Notch Signaling Pathway

    Selected BioSystems Pathways for TP73 (see all 8)
        Apoptosis
    DNA damage response (only ATM dependent)
    SIDS Susceptibility Pathways
    TP53 network
    TGF-beta Receptor Signaling Pathway


    4 Kegg Pathways  (Kegg details for TP73):
        p53 signaling pathway
    Hippo signaling pathway
    Neurotrophin signaling pathway
    Measles


    TP73 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TP73 (see all 6): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Breast Cancer in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TP73

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TP73 (O153501, 2, 3 ENSP000003675454) via UniProtKB, MINT, STRING, and/or I2D (see all 163)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITCHQ96J021, 2, 3, ENSP000003639984EBI-389619,EBI-1564678 MINT-3389196 MINT-3389321 MINT-3389044 MINT-3389118 MINT-3389173 MINT-3389070 MINT-3389148 MINT-3389300 I2D: score=4 STRING: ENSP00000363998
    YAP1P469371, 2, 3, ENSP000002824414EBI-389619,EBI-1044059 MINT-3388748 MINT-3388922 MINT-3388949 MINT-3388697 MINT-3388978 MINT-3388723 MINT-3388775 I2D: score=4 STRING: ENSP00000282441
    WWOXQ9NZC72, 3, ENSP000003861614MINT-60129 MINT-60098 MINT-60104 MINT-60132 MINT-60099 MINT-60101 MINT-60131 MINT-60103 MINT-60106 MINT-60130 MINT-60102 MINT-60128 MINT-60105 MINT-60100 I2D: score=2 STRING: ENSP00000386161
    HIST1H4LP628053, ENSP000003482584I2D: score=1 STRING: ENSP00000348258
    HIST1H4AP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 37):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IBA--
    GO:0000187activation of MAPK activity IEA--
    GO:0001822kidney development IEA--
    GO:0001836release of cytochrome c from mitochondria IEA--
    GO:0006298mismatch repair TAS10391249

    TP73 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TP73 (P73)

    Selected Novoseek inferred chemical compound relationships for TP73 gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    noxa 63 19 20195489 (3), 20160496 (2), 15572378 (2), 16899408 (1) (see all 9)
    cisplatin 56 94 16815295 (6), 16135520 (5), 16526280 (5), 16773194 (4) (see all 39)
    o6-methylguanine 44.4 4 16231140 (1), 19347729 (1), 14654977 (1), 15197802 (1)
    dmso 44 23 17287142 (2), 15805112 (1), 11423969 (1), 16630058 (1) (see all 16)
    5-aza-2'deoxycytidine 42.8 7 15015578 (3), 15609309 (1), 14733783 (1), 16193303 (1)
    adriamycin 31.1 26 11269743 (5), 19523927 (2), 15849742 (2), 15678153 (1) (see all 8)
    amino acid 23.3 1 10383137 (1)
    doxorubicin 8.51 4 19082486 (1), 16631755 (1), 17363502 (1)
    imatinib 8.2 7 18559370 (3), 16741250 (2)
    fatty acid 5.23 1 19517019 (1)



    TP73 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for TP73 gene (13 alternative transcripts): 
    NM_001126240.2  NM_001126241.2  NM_001126242.2  NM_001204184.1  NM_001204185.1  NM_001204186.1  NM_001204187.1  NM_001204188.1  
    NM_001204189.1  NM_001204190.1  NM_001204191.1  NM_001204192.1  NM_005427.3  

    Unigene Cluster for TP73:

    Tumor protein p73
    Hs.192132  [show with all ESTs]
    Unigene Representative Sequence: NM_005427
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378295(uc001akp.3 uc021ofb.1 uc021ofc.1 uc021ofd.1 uc021ofe.1 uc021off.1)
    ENST00000604074 ENST00000354437 ENST00000603362 ENST00000604479 ENST00000378285
    ENST00000378280(uc010nzj.2) ENST00000378288(uc021ofg.1 uc021ofh.1 uc021ofi.1 uc001akr.3 uc009vlk.2 uc001aks.3 uc010nzk.2 uc010nzl.2)
    ENST00000603364 ENST00000604194 ENST00000378290(uc009vll.3) ENST00000604566
    ENST00000357733 ENST00000346387

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TP73 (see all 41):
    hsa-miR-323-3p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-429 hsa-miR-106a hsa-miR-449a hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidTP73 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TP73
    Clone
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    OriGene ORF clones in mouse, rat for TP73
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 13): TP73 (NM_001204186)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TP73
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP73
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TP73
      QuantiTect SYBR Green Assays in human, mouse, rat TP73
      QuantiFast Probe-based Assays in human, mouse, rat TP73

    Additional mRNA sequence: 

    AB055065.1 AB055066.1 AK295669.1 AK302118.1 AK304177.1 AK304784.1 AK310432.1 AY040827.1 
    AY040828.1 AY040829.1 BC117251.1 BC117253.1 Y11416.1 

    9 DOTS entries:

    DT.100748937  DT.100680877  DT.406070  DT.95098410  DT.97824210  DT.100018189  DT.121356582  DT.121356601 
    DT.91967156 

    Selected AceView cDNA sequences (see all 32):

    CR599961 NM_005427 AB055065 AA908299 AY040829 Y11416 BX349978 AB055066 
    BX280538 AY040827 BM471663 BX348733 AY040828 BQ669420 BE295836 BI092821 
    AL528847 BX108274 AA614544 BI087031 BF304617 AA936771 BF303874 AW503182 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TP73 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTACCGCC
    TP73 Expression
    About this image


    TP73 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Mature Choroid Plexus Cells Choroid Plexus
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Ovary (Reproductive System)
             Oviduct
     
     Eye (Sensory Organs)
             Retina
    TP73 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TP73 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.192132

    UniProtKB/Swiss-Prot: P73_HUMAN, O15350
    Tissue specificity: Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain,
    kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed
    in fetal tissue

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TP73 (see all 6): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Breast Cancer in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TP73 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trp731 , 5 transformation related protein 731, 5 85.78(n)1
    90.1(a)1
      4 (83.79 cM)5
    220621  NM_011642.31  NP_035772.21 
     1540562535 
    chicken
    (Gallus gallus)
    Aves TP731 tumor protein p73 80.28(n)
    84.05(a)
      419382  XM_004947367.1  XP_004947424.1 
    lizard
    (Anolis carolinensis)
    Reptilia TP736
    tumor protein p73
    80(a)
    1 ↔ 1
    GL344123.1(32954-70924)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tp731 tumor protein p73 72.34(n)
    79.01(a)
      100496308  XM_002933855.2  XP_002933901.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tp732 tumor protein p73 75.59(n)   368221  AY365192.1 


    ENSEMBL Gene Tree for TP73 (if available)
    TreeFam Gene Tree for TP73 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TP73 gene
    TP532  TP632  
    2 SIMAP similar genes for TP73 using alignment to 2 protein entries:     P73_HUMAN (see all proteins):
    TP63    TP53

    TP73 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TP73 (see all 2328)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1125354451,2
    C,F--3572609(+) GGTGCG/AGGCAC 6 -- int12Minor allele frequency- A:0.10CSA WA 119
    rs1160358421,2
    C,F--3575320(+) ATGGCA/GTATTT 6 -- int11Minor allele frequency- G:0.03NA 120
    rs354904531,2
    C--3575434(+) TATTTT/AGGGGT 6 -- int11Minor allele frequency- A:0.50WA 2
    rs600730911,2
    C--3575741(+) AAAAAA/-GCTAA 6 -- int11Minor allele frequency- -:0.00CSA 2
    rs57721141,2
    C,F--3575742(+) AAAAAA/-GCTAA 6 -- int1 trp32Minor allele frequency- -:0.50NA 4
    rs566664561,2
    C--3576416(+) TTTTT-/TAGTAG 6 -- int10--------
    rs30346061,2
    C--3578287(-) ATATATA/-CACAA 6 -- int11Minor allele frequency- -:0.50CSA 2
    rs1480086591,2
    C--3578287(+) TTGTG-/TATA  
            
    TATAT
    6 -- int10--------
    rs1163075111,2
    C,F--3580699(+) CGTGTA/GTGTAA 6 -- us2k11Minor allele frequency- G:0.03NA 120
    rs1132667331,2
    C--3580792(+) CTCACA/GCTCCA 6 -- us2k12Minor allele frequency- G:0.33CSA 3

    HapMap Linkage Disequilibrium report for TP73 (3569084 - 3652765 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TP73 (see all 31):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2729250CNV Deletion23290073
    esv1634361CNV Deletion17803354
    esv2729473CNV Deletion23290073
    esv2729584CNV Deletion23290073
    esv2729695CNV Deletion23290073
    esv2729139CNV Deletion23290073
    esv994567CNV Deletion20482838
    esv2729028CNV Deletion23290073
    esv2729361CNV Deletion23290073
    esv1032022CNV Insertion17803354

    Human Gene Mutation Database (HGMD): TP73
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing TP73:
    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing TP73
    DNA2.0 Custom Variant and Variant Library Synthesis for TP73

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601990    OMIM disorders: --

    Selected diseases for TP73 (see all 117):    
    About MalaCards
    neuroblastoma    ependymoblastoma    tetraploidy    neurofibrosarcoma
    eccrine porocarcinoma    plasma cell leukemia    thyroid lymphoma    epstein-barr virus-associated gastric carcinoma
    neurofibroma    alexia    pyogenic granuloma    xeroderma pigmentosum, group c
    cervical squamous cell carcinoma    astrocytoma    cervical intraepithelial neoplasia    anaplastic astrocytoma
    pilocytic astrocytoma    brain cancer    laryngeal squamous cell carcinoma    bile duct carcinoma

    1 disease from the University of Copenhagen DISEASES database for TP73:
    Cancer

    TP73 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for TP73 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 72.1 594 14719122 (6), 10773878 (6), 10341287 (6), 16007185 (5) (see all 99)
    cancer 64 179 11139314 (4), 19754415 (3), 18583938 (3), 10362363 (3) (see all 99)
    allelic loss 60.4 19 11510689 (1), 11301342 (1), 10023682 (1), 10371354 (1) (see all 15)
    oligodendroglial tumors 54 9 11920588 (5), 12241107 (1), 11487055 (1)
    carcinoma squamous cell 51.8 25 10753204 (2), 17699776 (2), 15180941 (2), 15390192 (2) (see all 19)
    oligodendroglioma 45.6 14 10953317 (3), 9721206 (3), 10732753 (1), 12200621 (1) (see all 5)
    retinoblastoma 38.4 9 18619959 (4), 12584188 (1), 11709051 (1), 19643581 (1) (see all 6)
    plasma cell leukemia 36.9 1 10602435 (1)
    primary tumor 36.5 21 16750334 (4), 10935473 (1), 11859406 (1), 14760085 (1) (see all 12)
    promyelocytic leukemia 35.2 4 19111660 (1), 11559539 (1), 15184504 (1), 15893728 (1)

    Genetic Association Database (GAD): TP73
    Human Genome Epidemiology (HuGE) Navigator: TP73 (44 documents)
    Tumor Gene Database (TGDB): TP73

    Export disorders for TP73 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TP73 gene, integrated from 10 sources (see all 912):
    (articles sorted by number of sources associating them with TP73)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. (PubMed id 9288759)1, 2, 3, 9 Kaghad M....Caput D. (Cell 1997)
    2. Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation. (PubMed id 19490146)1, 2, 9 Sang M.... Ozaki T. (Genes Cells 2009)
    3. Combined effects of p73 and MDM2 polymorphisms on the risk of lung cancer. (PubMed id 17013834)1, 4, 9 Jun H.J....Park J.Y. (Mol. Carcinog. 2007)
    4. A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity. (PubMed id 12890487)1, 2, 9 Miyazaki K.... Nakagawara A. (Biochem. Biophys. Res. Commun. 2003)
    5. [Association of the responsiveness of advanced non-small cell lung cancer to platinum-based chemotherapy with p53 and p73 polymorphisms]. (PubMed id 16750013)1, 4, 9 Yuan P....Lin D.X. (Zhonghua Zhong Liu Za Zhi 2006)
    6. Combined effects of the p53 and p73 polymorphisms on lung cancer risk. (PubMed id 16434604)1, 4, 9 Schabath M.B....Spitz M.R. (amp 2006)
    7. A case-control study on the combined effects of p53 and p73 polymorphisms on head and neck cancer risk in an Italian population. (PubMed id 19426493)1, 4, 9 GallA- P....Boccia S. (BMC Cancer 2009)
    8. Mutational analysis of p73 and p53 in human cancer cell lines. (PubMed id 10362363)1, 2, 9 Yoshikawa H....Harris C.C. (Oncogene 1999)
    9. The emerging p53 gene family. (PubMed id 10203277)1, 2, 9 Kaelin W.G. Jr. (J. Natl. Cancer Inst. 1999)
    10. Polymorphisms at p53, p73, and MDM2 loci modulate the risk of tobacco associated leukoplakia and oral cancer. (PubMed id 19204927)1, 4, 9 Misra C....Roychoudhury S. (Mol. Carcinog. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7161 HGNC: 12003 AceView: TP73 Ensembl:ENSG00000078900 euGenes: HUgn7161
    ECgene: TP73 Kegg: 7161 H-InvDB: TP73

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TP73 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TP73 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TP73 gene:
    Search GeneIP for patents involving TP73

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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