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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TP63 Gene

protein-coding   GIFtS: 65
GCID: GC03P189349

tumor protein p63

(Previous names: tumor protein p73-like, tumor protein p53-like, tumor protein...)
(Previous symbols: TP73L, TP53L, TP53CP)
 Explore 179 diseases affiliated with
TP63 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TP63    

Aliases
for TP63 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tumor Protein P631 2     Keratinocyte Transcription Factor KET2 3
KET1 2 3 5     Transformation-Related Protein 632 3
TP73L1 2 3 5     CUSP2 3
P511     P401
P633     LMS2 5
P73L3     RHS2 5
EEC31 2 5     Tumor Protein P53-Like1
OFC81 2 5     AIS2
SHFM41 2 5     B(P51A)1
NBP1 2     B(P51B)1
TP53CP1 2     Amplified In Squamous Cell Carcinoma2
TP53L1 2     Tumor Protein 632
P53CP1     Tumor Protein P63 DeltaN Isoform Delta2
P73H3     P633
Tumor Protein P53-Competing Protein1 2     P73H3
Tumor Protein P73-Like1 3     P73L3
Chronic Ulcerative Stomatitis Protein2 3     

External Ids:    HGNC: 159791   Entrez Gene: 86262   Ensembl: ENSG000000732827   OMIM: 6032735   UniProtKB: Q9H3D43   

Export aliases for TP63 gene to outside databases

Previous GC identifers: GC03P186351 GC03P190832 GC03P186752


Summaries
for TP63 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TP63:
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful
in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/-
mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary
glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are
associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4);
ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary
syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative
promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different
proteins have been reported but the biological validity and the full-length nature of these variants have not been
determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: P63_HUMAN, Q9H3D4
Function: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a
varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific
activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of
p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in
Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The
ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and
regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb
formation from the apical ectodermal ridge. Activates transcription of the p21 promoter

Gene Wiki entry for TP63


Genomic Views
for TP63 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TP63 gene promoter:
         GR   GR-beta   p300   Lmo2   CUTL1   Evi-1   AREB6   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TP63 promoter sequence
   Search SABiosciences Chromatin IP Primers for TP63

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP63


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28   Ensembl cytogenetic band:  3q28   HGNC cytogenetic band: 3q27-q29

TP63 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP63 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P189349:  view genomic region     (about GC identifiers)

Start:
 189,349,205 bp from pter      End:
 189,615,068 bp from pter
Size:
 265,864 bases      Orientation:
 plus strand

Proteins
for TP63 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: P63_HUMAN, Q9H3D4 (See protein sequence)
Recommended Name: Tumor protein 63  
Size: 680 amino acids; 76785 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
Isoforms Alpha and Gamma interact with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Isoform
1 and isoform 2 interact with WWP1. Interacts with PDS5A. Isoform 5 (via activation domain) interacts with NOC2L
Subcellular location: Nucleus
Sequence caution: Sequence=AAF43486.1; Type=Erroneous initiation; Sequence=AAF43487.1; Type=Erroneous initiation;
Sequence=AAF43488.1; Type=Erroneous initiation; Sequence=AAF43489.1; Type=Erroneous initiation; Sequence=AAF61624.1;
Type=Frameshift; Positions=26; Sequence=BAA32592.1; Type=Frameshift; Positions=26; Sequence=BAA32593.1;
Type=Frameshift; Positions=26;
6/12 PDB 3D structures from and Proteopedia for TP63 (see all 12):
1RG6 (3D)        2RMN (3D)        2Y9T (3D)        2Y9U (3D)        3QYM (3D)        3QYN (3D)    
Secondary accessions: O75080 O75195 O75922 O76078 Q6VEG2 Q6VEG3 Q6VEG4 Q6VFJ1 Q6VFJ2 Q6VFJ3 Q6VH20
Q7LDI3 Q7LDI4 Q7LDI5 Q96KR0 Q9H3D2 Q9H3D3 Q9H3P8 Q9NPH7 Q9P1B4 Q9P1B5 Q9P1B6 Q9P1B7 Q9UBV9 Q9UE10
Q9UP26 Q9UP27 Q9UP28 Q9UP74
Alternative promoter usage, Alternative splicing: 12 isoforms:  Q9H3D4-1   Q9H3D4-2   Q9H3D4-3   Q9H3D4-4   Q9H3D4-5   Q9H3D4-6   Q9H3D4-7   Q9H3D4-8   
Q9H3D4-9   Q9H3D4-10   Q9H3D4-11   Q9H3D4-12   (Produced by alternative splicing of isoform 2. No experimental confirmation available. Variant in position: 6:N->H (in ADULT syndrome))

Explore the universe of human proteins at neXtProt for TP63: NX_Q9H3D4

Post-translational modifications:

  • May be sumoylated (By similarity)1
  • Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H3D4

    • TP63 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001108450.1  NP_001108451.1  NP_001108452.1  NP_001108453.1  NP_001108454.1  NP_003713.3  

    ENSEMBL proteins: 
     ENSP00000264731   ENSP00000407144   ENSP00000317510   ENSP00000376253   ENSP00000394337  
     ENSP00000371495   ENSP00000346614   ENSP00000401661   ENSP00000392488   ENSP00000376256  
     ENSP00000376254   ENSP00000387839   ENSP00000389485  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): TP63
    OriGene Protein Over-expression Lysate (see all 4): TP63
    OriGene Custom Protein Services for TP63 
    GenScript Custom Purified and Recombinant Proteins Services for TP63
    Novus Biologicals TP63 Proteins
    Novus Biologicals TP63 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TP63

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IBA--
    GO:0000790nuclear chromatin IDA--
    GO:0005634nucleus NAS9774969
    GO:0005654nucleoplasm IDA--
    GO:0005667transcription factor complex IBA--


    TP63 for ontologies           About GeneDecksing



    TP63 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TP63
    R&D Systems Antibodies for TP63 (p63/TP73L)
    Cell Signaling Technology (CST) Antibodies for TP63  (p63)
    OriGene Antibodies (see all 7): TP63
    OriGene Custom Antibody Services for TP63 
    GenScript Custom Superior Antibodies Services for TP63
    Novus Biologicals TP63 Antibodies
    Abcam antibodies for TP63 
    Uscn Antibodies for TP63
    ThermoFisher Antibodies for TP63

    Assay Products for TP63: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems Multiplex/Array Assay Kits & Reagents for TP63 (p63/TP73L)
    GenScript Custom Assay Services for TP63
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TP63

    Protein Domains /
    Families
    for TP63 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TP63 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR011615 p53_DNA-bd
     IPR012346 p53/RUNT-type_TF_DNA-bd
     IPR002117 p53_tumour_suppressor
     IPR013761 SAM/pointed
     IPR008967 p53-like_TF_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q9H3D4

    ProtoNet protein and cluster: Q9H3D4

    3 Blocks protein families:
    IPB001660 Sterile alpha motif SAM
    IPB010991 p53
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: P63_HUMAN, Q9H3D4
    Domain: The transactivation inhibitory domain (TID) can interact with, and inhibit the activity of the N-terminal
    transcriptional activation domain of TA*-type isoforms
    Similarity: Belongs to the p53 family
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Function
    for TP63 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: P63_HUMAN, Q9H3D4
    Function: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a
    varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific
    activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of
    p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in
    Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The
    ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and
    regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb
    formation from the apical ectodermal ridge. Activates transcription of the p21 promoter

         Genatlas biochemistry entry for TP63:
    TP63 homolog to TP53 and to TP73,highly expressed in the basal or progenitor layers of many epithelial tissues,encoding
    six isoforms transcribed from two promoters,one yielding,the other lacking a transactivation domain (respectively
    TA-p63,Delta N-p63),combined with alternative splicing producing the isotypes alpha,beta,gamma,playing a critical in
    the maintenance of the progenitor-cell populations necessary to sustain epithelial development and morphogenesis

    miRNA
    Products:            		miRTarBase miRNAs that target TP63:
    hsa-mir-203 (MIRT004248), hsa-mir-21 (MIRT005329), hsa-mir-92a (MIRT004281)

    OriGene 3'-UTR Clone (see all 6): TP63
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TP63
    8/70 QIAGEN miScript miRNA Assays for microRNAs that regulate TP63 (see all 70):
    hsa-miR-520e hsa-miR-218-1* hsa-miR-578 hsa-miR-519a hsa-miR-3921 hsa-miR-149 hsa-miR-4325 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmid: TP63 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TP63 (see all 4)
    OriGene shRNA RFP: TP63
    OriGene siRNA: TP63
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TP63

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TP63

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TP63 (see all 14)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP63 (see all 8)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): TP63 (NM_003722)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TP63
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP63 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TP63
    Search LifeMap BioReagents cell lines for TP63

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP63

    Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0002039p53 binding IBA--
    GO:0003677DNA binding NAS9662346
    GO:0003682chromatin binding IDA--
    GO:0003684damaged DNA binding IBA--


    TP63 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for TP63:
     Increased ID2::GFP protein exp  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-outs for TP63: Trp63tm2Brd Trp63tm1Fmc Trp63tm3.2Brd Trp63tm1Brd Trp63tm2Fmc Trp63tm1.1Elrf
         15/22 MGI mutant phenotypes (inferred from 11 alleles) (MGI details for Trp63) (see all 22):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  mortality/aging  muscle  normal 

    TP63 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TP63 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_Notch Signaling Pathway
    		Development_Notch Signaling Pathway1.00
    		Development Notch Signaling Pathway0.97
    2Cell Cycle / Checkpoint Control
    		Cell Cycle / Checkpoint Control1.00
    3TP53 network
    		TP53 network1.00
    4Direct p53 effectors
    		Direct p53 effectors1.00
    5DNA Damage
    		DNA Damage1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TP63
        Development Notch Signaling Pathway


    2 Cell Signaling Technology (CST) Pathways for TP63
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 GeneGo (Thomson Reuters) Pathway for TP63
        Development Notch Signaling Pathway

    3 BioSystems Pathways for TP63 
        TP53 network
    Apoptosis
    Direct p53 effectors



    TP63 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TP63

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/121 Interacting proteins for TP63 (Q9H3D41, 2, 3 ENSP000002647314) via UniProtKB, MINT, STRING, and/or I2D (see all 121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SATB2Q9UPW62, 3, ENSP000002609264MINT-8040599 MINT-8040614 MINT-8040583 MINT-8040535 MINT-8044440 MINT-8040642 MINT-8040525 MINT-8040627 I2D: score=1 STRING: ENSP00000260926
    TP53P046371, 3, ENSP000002693054EBI-2337775,EBI-366083 I2D: score=5 STRING: ENSP00000269305
    SMAD2Q157961, 3, ENSP000002621604EBI-2337775,EBI-1040141 I2D: score=1 STRING: ENSP00000262160
    CABLES1Q8TDN42, 3, ENSP000002569254MINT-7988829 MINT-7988887 MINT-7988815 MINT-7988867 MINT-7988849 MINT-7988907 MINT-7988919 I2D: score=1 STRING: ENSP00000256925
    PPP1R13BQ96KQ42, 3, ENSP000002025564MINT-45876 MINT-45877 I2D: score=3 STRING: ENSP00000202556
    About this table

    Gene Ontology (GO): 5/54 biological process terms (GO ID links to tree view) (see all 54):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IBA--
    GO:0001501skeletal system development IEA--
    GO:0001736establishment of planar polarity IEA--
    GO:0001738morphogenesis of a polarized epithelium ----
    GO:0001942hair follicle development ----


    TP63 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TP63 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TP63 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TP63
    10/27 Novoseek chemical compound relationships for TP63 gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    noxa 55.3 4 20195489 (1), 16363065 (1), 16413463 (1)
    dmso 51.2 33 15922574 (3), 16884378 (3), 16319057 (2), 19700772 (2) (see all 18)
    hematoxylin 49.9 5 16138374 (1), 12760288 (1), 15832080 (1), 17927587 (1) (see all 5)
    mucicarmine 43.1 2 11136565 (1), 11023104 (1)
    estrogen 40 27 12653579 (2), 16625090 (1), 17214855 (1), 20222992 (1) (see all 23)
    progesterone 36.5 21 14693844 (1), 16241993 (1), 16625090 (1), 20222992 (1) (see all 20)
    2-methoxyethanol 35.5 6 12811858 (4), 15762278 (1)
    paraffin 34.5 11 19877114 (1), 17285325 (1), 17912630 (1), 18619959 (1) (see all 11)
    b 723 32.3 5 16415794 (3), 14652817 (1), 17515511 (1)
    bromodeoxyuridine 18.8 15 19122469 (5), 19034133 (3), 16424398 (1), 16123387 (1)

    Search CenterWatch for drugs/clinical trials and news about TP63 / P63 

    Transcripts
    for TP63 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TP63 gene (6 alternative transcripts): 
    NM_001114978.1  NM_001114979.1  NM_001114980.1  NM_001114981.1  NM_001114982.1  NM_003722.4  

    Unigene Cluster for TP63:

    Tumor protein p63
    Hs.137569  [show with all ESTs]
    Unigene Representative Sequence: BC039815
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486398 ENST00000264731(uc003fry.2 uc003frz.2 uc010hzc.1)
    ENST00000418709(uc003frx.2) ENST00000320472 ENST00000392460 ENST00000440651
    ENST00000382063 ENST00000354600(uc003fsc.2 uc003fsd.2 uc021xir.1 uc010hzd.1)
    ENST00000434928 ENST00000460036(uc003fsa.2) ENST00000437221(uc003fsb.2)
    ENST00000392463 ENST00000392461 ENST00000449992 ENST00000456148(uc003fse.1)


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 6): TP63
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TP63
    8/70 QIAGEN miScript miRNA Assays for microRNAs that regulate TP63 (see all 70):
    hsa-miR-520e hsa-miR-218-1* hsa-miR-578 hsa-miR-519a hsa-miR-3921 hsa-miR-149 hsa-miR-4325 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmid: TP63 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TP63 (see all 4)
    OriGene shRNA RFP: TP63
    OriGene siRNA: TP63
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TP63
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TP63 (see all 14)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP63 (see all 8)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): TP63 (NM_003722)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TP63
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP63 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TP63
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TP63
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TP63
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP63

    Additional cDNA sequence: 

    AB010153.1 AB016072.1 AB042841.1 AF075428.1 AF075429.1 AF075430.1 AF075431.1 AF075432.1 
    AF075433.1 AF091627.1 AF116771.1 AJ315499.1 AK304127.1 BC039815.1 GQ202689.1 GQ202690.1 
    Y16961.1 

    9 DOTS entries:

    DT.113716  DT.95374522  DT.75166481  DT.95374523  DT.100767943  DT.100767944  DT.100767942  DT.91857800 
    DT.95374521 

    24/132 AceView cDNA sequences (see all 132):

    AF075432 AL698769 BQ027588 AA455929 AI278271 BC039815 NM_003722 BX447464 
    BQ045216 AA025687 W76490 AB016072 BX504901 AL698768 BM083305 BX103828 
    AW292021 AF075429 AI122593 AF075430 AF075431 BG676240 AF116771 AF075428 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TP63 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d
    SP1:                          -     -     -     -           -                                         -     -     -                                             
    SP2:                                                        -                                         -     -     -                                             
    SP3:                          -     -     -     -           -                                         -     -     -           -     -                           
    SP4:                                                  -     -                                         -     -     -                                             
    SP5:                          -     -     -     -           -                                         -                                                         


    ECgene alternative splicing isoforms for TP63

    Expression
    for TP63 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TP63 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAATAAAATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TP63 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungRespiratory BronchiolesBasal CellsLung
    LungTracheaBasal CellsLung
    LungTracheaTrachea Progenitor CellsLung
    KidneyRenal Collecting Duct SystemKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Mature airway epithelial cells (Directed differentia...)

    See TP63 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TP63

    SOURCE GeneReport for Unigene cluster: Hs.137569

    UniProtKB/Swiss-Prot: P63_HUMAN, Q9H3D4
    Tissue specificity: Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus,
    although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate
    express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas,
    but not in normal skin tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including TP63: 
              Cell Cycle in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for TP63 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TP63 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Trp631 , 5 transformation related protein 631, 5 91.27(n)1
    97.94(a)1    		   16 (17.37 cM)5
    220611  NM_001127259.11  NP_001120731.11 
     256837635 
    chicken
    (Gallus gallus)    		 Aves TP631 tumor protein p63 84.8(n)
    96.48(a)    		   374269  NM_204351.1  NP_989682.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    TP636
    (see all 3)    		 --
    		 84(a)
    71(a)
    (see all 3)    		 possible ortholog
    1 ↔ 1
    (see all 3)    		 GL343360.1(1238800-1240486)
    GL343386.1(24198-66403)
    African clawed frog
    (Xenopus laevis)    		 Amphibia tp73l-A2 p63 DNA binding protein/tumor protein p73-like 79.27(n)    AF314148.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii tp73l2 tumor protein p73-like 79.47(n)   260407  AF487944.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta p536
    		 p53
    		 16(a)
    		 possible ortholog
    		 3R(18875379-18879804)


    ENSEMBL Gene Tree for TP63 (if available)
    TreeFam Gene Tree for TP63 (if available) 

    Paralogs
    for TP63 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TP63 gene
    TP732  TP532  
    18/25 SIMAP similar genes for TP63 using alignment to 4 protein entries:     P63_HUMAN (see all proteins) (see all similar genes):
    RHOA    FLJ00047    KIAA0101    SNRPF    C12orf76    COQ5
    p53    NCKAP1L    HC6    LOC100996300    TP73    GALK2
    GEMIN6    PFKFB3    SH2B3    TP53    pp12301    FP6778

    TP63 for paralogs           About GeneDecksing



    Genomic Variants
    for TP63 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5040 NCBI SNPs in TP63 are shown (see all 5040)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1139939631,2
    		Cpathogenic189507605(+) TGGAAA/CACAAT 9 N H mis1 int10--------
    rs1139939651,2
    		Cpathogenic189526254(+) CCCAGA/GCCCGC 12 D G mis10--------
    rs1139939661,2
    		Cpathogenic189586385(+) TGGGCC/GGACGC 12 R G mis10--------
    rs1139939671,2
    		Cpathogenic189586386(+) GGGCCA/GACGCT 12 Q R mis10--------
    rs109373971,2
    		C,H,--189347230(+) TTAAAA/GACACA 3 -- us2k19Minor allele frequency- G:0.08NA WA CSA EA 369
    rs1409704551,2
    		--189347241(+) ACACAC/TTAGAG 3 -- us2k10--------
    rs1502277241,2
    		--189347254(+) GTTTGC/GAAATT 3 -- us2k10--------
    rs1388001911,2
    		--189347276(+) AGTCTA/GTATCC 3 -- us2k10--------
    rs1405593501,2
    		--189347283(+) ATCCCA/TGGAAG 3 -- us2k10--------
    rs359344951,2
    		C,F,--189347364(+) AAGGAA/GCACTA 3 -- us2k16Minor allele frequency- G:0.17NA WA EA 364

    HapMap Linkage Disequilibrium report for TP63 (189349205 - 189599205 bp, first 250kb of TP63)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 35 variations for TP63
         15/27 CNVs (see all 27): 91763 80042 98567 44097 80040 80041 91764 98568 22814 36120 59609 80043 98566 91766 91767
         8 Indels: 62136 51036 46351 11219 38060 59116 46352 33375
    Human Gene Mutation Database (HGMD): TP63

    Locus Specific Mutation Databases (LSDB): TP63

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TP63
    DNA2.0 Custom Variant and Variant Library Synthesis for TP63

    Disorders / Diseases
    for TP63 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TP63 for disorders           About GeneDecksing

    OMIM gene information: 603273   
    OMIM disorders: 604292  605289  106260  103285  603543  129400  
    UniProtKB/Swiss-Prot: P63_HUMAN, Q9H3D4
  • Defects in TP63 are the cause of acro-dermato-ungual-lacrimal-tooth syndrome (ADULT syndrome) [MIM:103285]; a
    • form of ectodermal dysplasia. Ectodermal dysplasias (EDs) constitute a heterogeneous group of developmental disorders
    affecting tissues of ectodermal origin. EDs are characterized by abnormal development of two or more ectodermal
    structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination
    of clinical features represents a different type of ectodermal dysplasia. ADULT syndrome involves ectrodactyly,
    syndactyly, finger- and toenail dysplasia, hypoplastic breasts and nipples, intensive freckling, lacrimal duct
    atresia, frontal alopecia, primary hypodontia, and loss of permanent teeth. ADULT differs significantly from EEC3
    syndrome by the absence of facial clefting
  • Defects in TP63 are the cause of ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) [MIM:106260]. AEC
    • is an autosomal dominant condition characterized by congenital ectodermal dysplasia with coarse, wiry, sparse hair,
    dystrophic nails, slight hypohidrosis, scalp infections, ankyloblepharon filiform adnatum, maxillary hypoplasia,
    hypodontia and cleft lip/palate
  • Defects in TP63 are the cause of ectrodactyly-ectodermal dysplasia-cleft lip/palate syndrome type 3 (EEC3)
    • [MIM:604292]. EEC3 is an autosomal dominant syndrome characterized by ectrodactyly of hands and feet, ectodermal
    dysplasia and facial clefting
  • Defects in TP63 are the cause of split-hand/foot malformation type 4 (SHFM4) [MIM:605289].
    • Split-hand/split-foot malformation is a limb malformation involving the central rays of the autopod and presenting
    with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and
    metatarsals. There is restricted overlap between the mutational spectra of EEC3 and SHFM4
  • Defects in TP63 are the cause of limb-mammary syndrome (LMS) [MIM:603543]. LMS is characterized by
    • ectrodactyly, cleft palate and mammary-gland abnormalities
  • Note=Defects in TP63 are a cause of cervical, colon, head and neck, lung and ovarian cancers
  • Defects in TP63 are a cause of ectodermal dysplasia Rapp-Hodgkin type (EDRH) [MIM:129400]; also called
    • Rapp-Hodgkin syndrome or anhidrotic ectodermal dysplasia with cleft lip/palate. Ectodermal dysplasia defines a
    heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDRH is
    characterized by the combination of anhidrotic ectodermal dysplasia, cleft lip, and cleft palate. The clinical
    syndrome is comprised of a characteristic facies (narrow nose and small mouth), wiry, slow-growing, and uncombable
    hair, sparse eyelashes and eyebrows, obstructed lacrimal puncta/epiphora, bilateral stenosis of external auditory
    canals, microsomia, hypodontia, cone-shaped incisors, enamel hypoplasia, dystrophic nails, and cleft lip/cleft palate
  • Defects in TP63 are the cause of non-syndromic orofacial cleft type 8 (OFC8) [MIM:129400]. Non-syndromic
    • orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are
    associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity
    from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and
    involving the upper gum

    20/179 diseases for TP63 (see all 179):    About MalaCards
    split hand/foot malformation    cleft lip/palate    cleft lip    limb-mammary syndrome
    orofacial cleft 8    ectodermal dysplasia    mayer-rokitansky-kuster-hauser syndrome    rokitansky-kuster-hauser syndrome
    orofacial cleft    squamous cell carcinoma    ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3    split-hand/foot malformation, type 4
    tricho-dento-osseous syndrome    ulcerative stomatitis    polymorphous low-grade adenocarcinoma    rapp-hodgkin syndrome
    carcinoma    stomatitis    adult syndrome    hay-wells syndrome

    4 diseases from the University of Copenhagen DISEASES database for TP63:
    Cleft lip     ADULT syndrome     Leiomyosarcoma     Ulcerative stomatitis

    10/97 Novoseek disease relationships for TP63 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aec syndrome 93.4 30 19676060 (2), 12766194 (2), 11159940 (2), 16365259 (2) (see all 20)
    rapp-hodgkin syndrome 90.7 10 15725251 (2), 12939657 (2), 12766194 (1), 15748593 (1) (see all 7)
    shfm4 89.3 6 16688749 (1), 16724007 (1), 18515319 (1), 16691619 (1) (see all 5)
    ectrodactyly 88.6 29 14656652 (4), 11462173 (2), 15736220 (2), 11903230 (2) (see all 19)
    ectodermal dysplasia 88.6 55 11903230 (3), 18633439 (2), 12766194 (2), 20424325 (2) (see all 37)
    ankyloblepharon 88.5 12 16365259 (2), 19681128 (1), 16177572 (1), 18364388 (1) (see all 10)
    limb-mammary syndrome 85.8 5 11462173 (2), 14656652 (1), 11929852 (1), 17164413 (1)
    adult syndrome 82.3 22 11528512 (3), 16724007 (3), 19781362 (3), 11929852 (2) (see all 11)
    malformation foot 77.6 8 11462173 (2), 14656652 (1), 11595015 (1), 17224651 (1) (see all 5)
    limb malformation 73.8 4 19676060 (1), 16724007 (1), 17609671 (1), 17041931 (1)

    Human Genome Epidemiology (HuGE) Navigator: TP63 (17 documents)

    Export disorders for TP63 gene to outside databases

    Publications
    for TP63 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TP63 gene, integrated from 9 sources (see all 1068):
    (articles sorted by number of sources associating them with TP63)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. (PubMed id 9774969)1, 2, 3, 9 Yang A.... McKeon F. (1998)
    2. Cloning and functional analysis of human p51, which structurally and functionally resembles p53. (PubMed id 9662378)1, 2, 3 Osada M....Ikawa S. (1998)
    3. Transcriptional dysregulation of the p73L/p63/p51/p40/KET gene in human squamous cell carcinomas: expression of Delta Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51. (PubMed id 11336476)1, 2, 9 Senoo M.... Habu S. (2001)
    4. High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53. (PubMed id 11477076)1, 2, 9 Klein C.... Hansen S. (2001)
    5. Mutation and expression of the p51 gene in human lung cancer. (PubMed id 10935472)1, 2, 9 Tani M....Yokota J. (1999)
    6. p63 gene mutations in EEC syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype- phenotype correlation. (PubMed id 11462173)1, 2, 9 van Bokhoven H.... Brunner H.G. (2001)
    7. p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53. (PubMed id 10373484)1, 2, 9 Davison T.S....Arrowsmith C.H. (1999)
    8. The p53 family member genes are involved in the Notch signal pathway. (PubMed id 11641404)1, 2, 9 Sasaki Y.... Tokino T. (2002)
    9. A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism. (PubMed id 12446779)1, 2, 9 Serber Z.... Doetsch V. (2002)
    10. Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains. (PubMed id 12446784)1, 2, 9 Ghioni P....Guerrini L. (2002)

    External Searches for TP63 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TP63 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8626 HGNC: 15979 AceView: TP73L Ensembl:ENSG00000073282 euGenes: HUgn8626
    ECgene: TP63 H-InvDB: TP63

    Other Databases showing TP63 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TP63 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TP63 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TP63

    Intellectual Property
    for TP63 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TP63 gene:
    Search GeneIP for patents involving TP63

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    von Willebrand factor
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