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TP63 Gene

protein-coding   GIFtS: 66
GCID: GC03P189349

Tumor Protein P63

(Previous names: tumor protein p73-like, tumor protein p53-like, tumor protein...)
(Previous symbols: TP73L, TP53L, TP53CP)
  See TP63-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Protein P631 2     OFC82 5
TP73L1 2 3 5     RHS2 5
KET2 3 5     SHFM42 5
TP53CP1 2     Tumor Protein P53-Like1
TP53L1 2     AIS2
Tumor Protein P53-Competing Protein1 2     B(p51A)2
Tumor Protein P73-Like1 3     B(p51B)2
Chronic Ulcerative Stomatitis Protein2 3     NBP2
Keratinocyte Transcription Factor KET2 3     Amplified In Squamous Cell Carcinoma2
Transformation-Related Protein 632 3     p53CP2
CUSP2 3     p73H2
p402 3     Tumor Protein 632
p512 3     Tumor Protein P63 DeltaN Isoform Delta2
p632 3     P633
p73L2 3     P73H3
EEC32 5     P73L3
LMS2 5     

External Ids:    HGNC: 159791   Entrez Gene: 86262   Ensembl: ENSG000000732827   OMIM: 6032735   UniProtKB: Q9H3D43   

Export aliases for TP63 gene to outside databases

Previous GC identifers: GC03P186351 GC03P190832 GC03P186752


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TP63 Gene:
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been
useful in defining the role this protein plays in the development and maintenance of stratified epithelial
tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such
as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium.
Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3);
split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome
(acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8.
Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding
different proteins. Many transcripts encoding different proteins have been reported but the biological validity
and the full-length nature of these variants have not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for TP63 Gene:
TP63 (tumor protein p63) is a protein-coding gene. Diseases associated with TP63 include eec syndrome, and chand syndrome. GO annotations related to this gene include identical protein binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TP73.

UniProtKB/Swiss-Prot: P63_HUMAN, Q9H3D4
Function: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a
varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform
specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for
initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated
oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of
epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial
stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated
embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the
p21 promoter

Gene Wiki entry for TP63 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TP63 gene promoter:
         GR   GR-beta   p300   Lmo2   CUTL1   Evi-1   AREB6   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TP63 promoter sequence
   Search Chromatin IP Primers for TP63

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TP63


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28   Ensembl cytogenetic band:  3q28   HGNC cytogenetic band: 3q27-q29

TP63 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP63 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P189349:  view genomic region     (about GC identifiers)

Start:
189,349,205 bp from pter      End:
189,615,068 bp from pter
Size:
265,864 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: P63_HUMAN, Q9H3D4 (See protein sequence)
Recommended Name: Tumor protein 63  
Size: 680 amino acids; 76785 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
Isoforms Alpha and Gamma interact with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity.
Isoform 1 and isoform 2 interact with WWP1. Interacts with PDS5A. Isoform 5 (via activation domain) interacts
with NOC2L
Sequence caution: Sequence=AAF43486.1; Type=Erroneous initiation; Sequence=AAF43487.1; Type=Erroneous initiation;
Sequence=AAF43488.1; Type=Erroneous initiation; Sequence=AAF43489.1; Type=Erroneous initiation;
Sequence=AAF61624.1; Type=Frameshift; Positions=26; Sequence=BAA32592.1; Type=Frameshift; Positions=26;
Sequence=BAA32593.1; Type=Frameshift; Positions=26;
Selected PDB 3D structures from and Proteopedia for TP63 (see all 12):
1RG6 (3D)        2RMN (3D)        2Y9T (3D)        2Y9U (3D)        3QYM (3D)        3QYN (3D)    
Secondary accessions: O75080 O75195 O75922 O76078 Q6VEG2 Q6VEG3 Q6VEG4 Q6VFJ1 Q6VFJ2 Q6VFJ3
Q6VH20 Q7LDI3 Q7LDI4 Q7LDI5 Q96KR0 Q9H3D2 Q9H3D3 Q9H3P8 Q9NPH7 Q9P1B4 Q9P1B5 Q9P1B6 Q9P1B7
Q9UBV9 Q9UE10 Q9UP26 Q9UP27 Q9UP28 Q9UP74
Alternative promoter usage, Alternative splicing: 12 isoforms:  Q9H3D4-1   Q9H3D4-2   Q9H3D4-3   Q9H3D4-4   Q9H3D4-5   Q9H3D4-6   Q9H3D4-7   Q9H3D4-8   
Q9H3D4-9   Q9H3D4-10   Q9H3D4-11   Q9H3D4-12   (Produced by alternative splicing of isoform 2. No experimental confirmation available. Variant in position: 6:N->H (in ADULT syndrome))

Explore the universe of human proteins at neXtProt for TP63: NX_Q9H3D4

Explore proteomics data for TP63 at MOPED

Post-translational modifications: 

  • May be sumoylated (By similarity)1
  • Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TP63 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001108450.1  NP_001108451.1  NP_001108452.1  NP_001108453.1  NP_001108454.1  NP_003713.3  

    ENSEMBL proteins: 
     ENSP00000264731   ENSP00000407144   ENSP00000317510   ENSP00000376253   ENSP00000394337  
     ENSP00000346614   ENSP00000401661   ENSP00000392488   ENSP00000376256   ENSP00000376254  
     ENSP00000387839   ENSP00000389485   ENSP00000371495  

    TP63 Human Recombinant Protein Products:

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    OriGene Purified Proteins for TP63
    OriGene Protein Over-expression Lysate for TP63
    OriGene MassSpec for TP63
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    Sino Biological Recombinant Protein for TP63
    Sino Biological Cell Lysate for TP63
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TP63

     
    Search eBioscience for Proteins for TP63 

     
    antibodies-online proteins for TP63 (2 products) 

     
    antibodies-online peptides for TP63

    TP63 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TP63 (p63/TP73L)
    Cell Signaling Technology (CST) Antibodies for TP63  (p63)
    OriGene Antibodies for TP63
    OriGene Custom Antibody Services for TP63
    Novus Biologicals TP63 Antibodies
    Abcam antibodies for TP63 (Q96GH1, Q9H3D4)
    Cloud-Clone Corp. Antibodies for TP63
    ThermoFisher Antibodies for TP63
    Search LSBio for Antibodies for TP63
    antibodies-online antibodies for TP63 (68 products) 

    TP63 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TP63
    R&D Systems Proteome Profiler Antibody Arrays for TP63 (p63/TP73L)
    GenScript Custom Assay Services for TP63
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TP63
    Cloud-Clone Corp. CLIAs for TP63
    Search eBioscience for ELISAs for TP63 
    antibodies-online kits for TP63 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR011615 p53_DNA-bd
     IPR012346 p53/RUNT-type_TF_DNA-bd
     IPR002117 p53_tumour_suppressor
     IPR013761 SAM/pointed
     IPR008967 p53-like_TF_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q9H3D4

    ProtoNet protein and cluster: Q9H3D4

    3 Blocks protein domains:
    IPB001660 Sterile alpha motif SAM
    IPB010991 p53
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: P63_HUMAN, Q9H3D4
    Domain: The transactivation inhibitory domain (TID) can interact with, and inhibit the activity of the N-terminal
    transcriptional activation domain of TA*-type isoforms
    Similarity: Belongs to the p53 family
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Find genes that share domains with TP63           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P63_HUMAN, Q9H3D4
    Function: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a
    varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform
    specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for
    initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated
    oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of
    epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial
    stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated
    embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the
    p21 promoter

         Genatlas biochemistry entry for TP63:
    TP63 homolog to TP53 and to TP73,highly expressed in the basal or progenitor layers of many epithelial
    tissues,encoding six isoforms transcribed from two promoters,one yielding,the other lacking a transactivation
    domain (respectively TA-p63,Delta N-p63),combined with alternative splicing producing the isotypes
    alpha,beta,gamma,playing a critical in the maintenance of the progenitor-cell populations necessary to sustain
    epithelial development and morphogenesis

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0002039p53 binding IBA--
    GO:0003677DNA binding NAS9662346
    GO:0003682chromatin binding IDA--
    GO:0003684damaged DNA binding IBA--
         
    Find genes that share ontologies with TP63           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TP63:
     Increased ID2::GFP protein exp  Increased gamma-H2AX phosphory 

         Selected MGI mutant phenotypes (inferred from 13 alleles(MGI details for Trp63) (see all 22):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  mortality/aging  muscle  normal 

    Find genes that share phenotypes with TP63           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TP63: Trp63tm2Brd Trp63tm1Fmc Trp63tm3.2Brd Trp63tm1Brd Trp63tm2Fmc Trp63tm1.1Elrf

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TP63
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TP63

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TP63
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TP63

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  NNNGCATGTCCNGACATGCC 

    miRNA
    Products:
        
    miRTarBase miRNAs that target TP63:
    hsa-mir-203a (MIRT004248), hsa-mir-21-5p (MIRT005329), hsa-mir-92a-3p (MIRT004281), hsa-mir-124-3p (MIRT022864)

    Block miRNA regulation of human, mouse, rat TP63 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TP63 (see all 70):
    hsa-miR-520e hsa-miR-218-1* hsa-miR-578 hsa-miR-519a hsa-miR-3921 hsa-miR-149 hsa-miR-4325 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidTP63 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TP63
    Predesigned siRNA for gene silencing in human, mouse, rat TP63

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TP63

    Clone
    Products:
         
    OriGene clones in human, mouse for TP63 (see all 44)
    OriGene ORF clones in mouse, rat for TP63
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): TP63 (NM_003722)
    Sino Biological Human cDNA Clone for TP63
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TP63
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP63
    Addgene plasmids for TP63 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TP63 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP63


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    P63_HUMAN, Q9H3D4: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus4
    cytosol3
    cytoskeleton2
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IBA--
    GO:0000790nuclear chromatin IDA--
    GO:0005634nucleus NAS9774969
    GO:0005654nucleoplasm IDA--
    GO:0005667transcription factor complex IBA--

    Find genes that share ontologies with TP63           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TP63 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    DNA Damage0.32
    2Development NOTCH1 mediated pathway for NF KB activity modulation
    Development Notch Signaling Pathway0.50
    3Apoptosis (WikiPathways)
    Apoptosis0.38
    4TP53 network
    TP53 network
    5MicroRNAs in cancer
    MicroRNAs in cancer


    Find genes that share SuperPaths with TP63           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for TP63
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 GeneGo (Thomson Reuters) Pathway for TP63
        Development Notch Signaling Pathway

    3 BioSystems Pathways for TP63
        Apoptosis
    TP53 network
    Direct p53 effectors



    1 Kegg Pathway  (Kegg details for TP63):
        MicroRNAs in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TP63: 
              Cell Cycle in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TP63

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TP63 (Q9H3D41, 2, 3 ENSP000002647314) via UniProtKB, MINT, STRING, and/or I2D (see all 153)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SATB2Q9UPW61, 2, 3, ENSP000002609264EBI-6481107,EBI-8298169 MINT-8040599 MINT-8040614 MINT-8040583 MINT-8040535 MINT-8044440 MINT-8040642 MINT-8040525 MINT-8040627 I2D: score=1 STRING: ENSP00000260926
    CABLES1Q8TDN41, 2, 3, ENSP000002569254EBI-2400586,EBI-604615 MINT-7988829 MINT-7988887 MINT-7988815 MINT-7988867 MINT-7988849 MINT-7988907 MINT-7988919 I2D: score=1 STRING: ENSP00000256925
    TP53P046371, 3, ENSP000002693054EBI-2337775,EBI-366083 I2D: score=5 STRING: ENSP00000269305
    SMAD2Q157961, 3, ENSP000002621604EBI-2337775,EBI-1040141 I2D: score=1 STRING: ENSP00000262160
    PPP1R13BQ96KQ42, 3, ENSP000002025564MINT-45876 MINT-45877 I2D: score=3 STRING: ENSP00000202556
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 59):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IBA--
    GO:0001501skeletal system development IEA--
    GO:0001736establishment of planar polarity IEA--
    GO:0001738morphogenesis of a polarized epithelium ----
    GO:0001942hair follicle development ----

    Find genes that share ontologies with TP63           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TP63 (P63)

    Selected Novoseek inferred chemical compound relationships for TP63 gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    noxa 55.3 4 20195489 (1), 16363065 (1), 16413463 (1)
    dmso 51.2 33 15922574 (3), 16884378 (3), 16319057 (2), 19700772 (2) (see all 18)
    hematoxylin 49.9 5 16138374 (1), 12760288 (1), 15832080 (1), 17927587 (1) (see all 5)
    mucicarmine 43.1 2 11136565 (1), 11023104 (1)
    estrogen 40 27 12653579 (2), 16625090 (1), 17214855 (1), 20222992 (1) (see all 23)
    progesterone 36.5 21 14693844 (1), 16241993 (1), 16625090 (1), 20222992 (1) (see all 20)
    2-methoxyethanol 35.5 6 12811858 (4), 15762278 (1)
    paraffin 34.5 11 19877114 (1), 17285325 (1), 17912630 (1), 18619959 (1) (see all 11)
    b 723 32.3 5 16415794 (3), 14652817 (1), 17515511 (1)
    bromodeoxyuridine 18.8 15 19122469 (5), 19034133 (3), 16424398 (1), 16123387 (1)



    Find genes that share compounds with TP63           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TP63 gene (6 alternative transcripts): 
    NM_001114978.1  NM_001114979.1  NM_001114980.1  NM_001114981.1  NM_001114982.1  NM_003722.4  

    Unigene Cluster for TP63:

    Tumor protein p63
    Hs.137569  [show with all ESTs]
    Unigene Representative Sequence: BC039815
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486398 ENST00000264731(uc003fry.2 uc003frz.2 uc010hzc.1)
    ENST00000418709(uc003frx.2) ENST00000320472 ENST00000392460 ENST00000440651
    ENST00000354600(uc003fsc.2 uc003fsd.2 uc021xir.1 uc010hzd.1)
    ENST00000434928 ENST00000460036(uc003fsa.2) ENST00000437221(uc003fsb.2)
    ENST00000392463 ENST00000392461 ENST00000449992 ENST00000456148(uc003fse.1)
    ENST00000382063
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TP63 (see all 70):
    hsa-miR-520e hsa-miR-218-1* hsa-miR-578 hsa-miR-519a hsa-miR-3921 hsa-miR-149 hsa-miR-4325 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidTP63 3' UTR sequence
    Inhib. RNA
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    OriGene clones in human, mouse for TP63 (see all 44)
    OriGene ORF clones in mouse, rat for TP63
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): TP63 (NM_003722)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TP63
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP63
    Addgene plasmids for TP63 
    Primer
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    OriGene qPCR primer pairs and template standards for TP63
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      QuantiTect SYBR Green Assays in human, mouse, rat TP63
      QuantiFast Probe-based Assays in human, mouse, rat TP63

    Additional mRNA sequence: 

    AB010153.1 AB016072.1 AB042841.1 AF075428.1 AF075429.1 AF075430.1 AF075431.1 AF075432.1 
    AF075433.1 AF091627.1 AF116771.1 AJ315499.1 AK304127.1 BC039815.1 GQ202689.1 GQ202690.1 
    Y16961.1 

    9 DOTS entries:

    DT.113716  DT.95374522  DT.75166481  DT.95374523  DT.100767943  DT.100767944  DT.100767942  DT.91857800 
    DT.95374521 

    Selected AceView cDNA sequences (see all 132):

    AI377044 BF436149 AA455929 W76490 AW292021 BX504901 AF075432 AA025687 
    NM_003722 AL698768 AI127157 BM083305 AB016072 BX103828 AF075431 AF075430 
    BQ027589 AI332920 AB042841 AI278271 BG676240 AF116771 BQ027588 AF075428 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TP63 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d
    SP1:                          -     -     -     -           -                                         -     -     -                                             
    SP2:                                                        -                                         -     -     -                                             
    SP3:                          -     -     -     -           -                                         -     -     -           -     -                           
    SP4:                                                  -     -                                         -     -     -                                             
    SP5:                          -     -     -     -           -                                         -                                                         


    ECgene alternative splicing isoforms for TP63

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TP63 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATAAAATT
    TP63 Expression
    About this image


    TP63 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 11 entries
             Limbal Basal Epithelial Cells Limbus Epithelium
             Limbal epithelial stem cells (family)
     
     Epithelial Cells
             Intermediate Keratinocytes Embryonic Epidermis
     
     Epidermis (Integumentary System)    fully expand to see all 5 entries
             Intermediate Keratinocytes Embryonic Epidermis
             Keratinocyte-like cells
     
     Ectoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Surface Ectoderm Cells Surface Ectoderm
             Activin-induced cells
     
     Hair
             Primary Hair Placode Cells Hair Follicle
    TP63 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TP63 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.137569

    UniProtKB/Swiss-Prot: P63_HUMAN, Q9H3D4
    Tissue specificity: Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and
    thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye
    and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous
    cell carcinomas, but not in normal skin tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TP63: 
              Cell Cycle in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TP63
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP63

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TP63 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trp631 , 5 transformation related protein 631, 5 91.27(n)1
    97.94(a)1
      16 (17.37 cM)5
    220611  NM_001127259.11  NP_001120731.11 
     256837635 
    chicken
    (Gallus gallus)
    Aves TP631 tumor protein p63 84.8(n)
    96.48(a)
      374269  NM_204351.1  NP_989682.1 
    lizard
    (Anolis carolinensis)
    Reptilia TP636
    tumor protein p63
    71(a)
    1 ↔ 1
    GL343386.1(24198-69112)
    African clawed frog
    (Xenopus laevis)
    Amphibia tp73l-A2 p63 DNA binding protein/tumor protein p73-like 79.27(n)    AF314148.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tp73l2 tumor protein p73-like 79.47(n)   260407  AF487944.1 


    ENSEMBL Gene Tree for TP63 (if available)
    TreeFam Gene Tree for TP63 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TP63 gene
    TP732  TP532  
    Selected SIMAP similar genes for TP63 using alignment to 4 protein entries:     P63_HUMAN (see all proteins) (see all similar genes):
    RHOA    FLJ00047    TBCB    SNRPF    C12orf76    COQ5
    p53    TP73    HC6    RBP7    GALK2    TP53
    GEMIN6    PFKFB3    SH2B3    pp12301    FP6778    TUBA1C

    Find genes that share paralogs with TP63           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TP63 (see all 5829)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0351294
    Ectodermal dysplasia, Rapp-Hodgkin type (EDRH)4--see VAR_0351292 S P mis40--------
    VAR_0208794
    Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC)4--see VAR_0208792 L F mis40--------
    VAR_0208714
    Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)4--see VAR_0208712 R W mis40--------
    VAR_0208724
    Colon cancer4--see VAR_0208722 P H mis40--------
    VAR_0208774
    Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)4--see VAR_0208772 C R mis40--------
    VAR_0327384
    Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)4--see VAR_0327382 R Q mis40--------
    VAR_0208704
    Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)4--see VAR_0208702 R Q mis40--------
    VAR_0327414
    Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)4--see VAR_0327412 R C mis40--------
    VAR_0327404
    Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)4--see VAR_0327402 S N mis40--------
    VAR_0327394
    Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)4--see VAR_0327392 C Y mis40--------

    HapMap Linkage Disequilibrium report for TP63 (189349205 - 189599205 bp, first 250kb of TP63)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TP63 (see all 38):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436370CNV Deletion17901297
    esv2656594CNV Deletion23128226
    esv2289340CNV Deletion18987734
    esv2476340CNV Deletion19546169
    esv2222823CNV Deletion18987734
    esv1003991CNV Deletion20482838
    esv2305625CNV Deletion18987734
    esv2726369CNV Deletion23290073
    esv2726367CNV Deletion23290073
    esv2726368CNV Deletion23290073

    Human Gene Mutation Database (HGMD): TP63
    Locus Specific Mutation Databases (LSDB): TP63

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TP63
    DNA2.0 Custom Variant and Variant Library Synthesis for TP63

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603273   
    OMIM disorders: 604292  605289  106260  103285  603543  129400  
    UniProtKB/Swiss-Prot: P63_HUMAN, Q9H3D4
  • Acro-dermato-ungual-lacrimal-tooth syndrome (ADULT syndrome) [MIM:103285]: A form of ectodermal
    dysplasia. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or
    more ectodermal structures. ADULT syndrome involves ectrodactyly, syndactyly, finger- and toenail dysplasia,
    hypoplastic breasts and nipples, intensive freckling, lacrimal duct atresia, frontal alopecia, primary hypodontia
    and loss of permanent teeth. ADULT syndrome differs significantly from EEC3 syndrome by the absence of facial
    clefting. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) [MIM:106260]: An autosomal dominant condition
    characterized by congenital ectodermal dysplasia with coarse, wiry, sparse hair, dystrophic nails, slight
    hypohidrosis, scalp infections, ankyloblepharon filiform adnatum, maxillary hypoplasia, hypodontia and cleft
    lip/palate. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3) [MIM:604292]: A form of
    ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal
    structures. It is an autosomal dominant syndrome characterized by ectrodactyly of hands and feet, ectodermal
    dysplasia and facial clefting. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • Split-hand/foot malformation 4 (SHFM4) [MIM:605289]: A limb malformation involving the central rays of
    the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of
    the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal
    and craniofacial findings, and orofacial clefting. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Limb-mammary syndrome (LMS) [MIM:603543]: Characterized by ectrodactyly, cleft palate and mammary-gland
    abnormalities. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Note=Defects in TP63 are a cause of cervical, colon, head and neck, lung and ovarian cancers
  • Ectodermal dysplasia, Rapp-Hodgkin type (EDRH) [MIM:129400]: A form of ectodermal dysplasia, a
    heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Characterized
    by the combination of anhidrotic ectodermal dysplasia, cleft lip, and cleft palate. The clinical syndrome is
    comprised of a characteristic facies (narrow nose and small mouth), wiry, slow-growing, and uncombable hair,
    sparse eyelashes and eyebrows, obstructed lacrimal puncta/epiphora, bilateral stenosis of external auditory
    canals, microsomia, hypodontia, cone-shaped incisors, enamel hypoplasia, dystrophic nails, and cleft lip/cleft
    palate. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Non-syndromic orofacial cleft 8 (OFC8) [MIM:129400]: A birth defect consisting of cleft lips with or
    without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on
    one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip
    extending into the floor of the nostril and involving the upper gum. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • Selected diseases for TP63 (see all 56):    
    About MalaCards
    eec syndrome    chand syndrome    cleft lip +/- cleft palate    ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3
    limb-mammary syndrome    carcinoma showing thymus-like differentiation    exstrophy of the bladder    split-hand/foot malformation, type 4
    cleft lip    adult syndrome    tp63-related disorders    mucoepidermoid carcinoma
    stomatitis    orofacial cleft 8    ankyloblepharon-ectodermal defects-cleft lip/palate syndrome    ulcerative stomatitis
    split hand foot malformation    rapp-hodgkin syndrome    bainbridge-ropers syndrome    lipoadenoma

    5 diseases from the University of Copenhagen DISEASES database for TP63:
    Cleft lip     ADULT syndrome     Leiomyosarcoma     Ulcerative stomatitis
    Syndactyly

    Find genes that share disorders with TP63           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TP63 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aec syndrome 93.4 30 19676060 (2), 12766194 (2), 11159940 (2), 16365259 (2) (see all 20)
    rapp-hodgkin syndrome 90.7 10 15725251 (2), 12939657 (2), 12766194 (1), 15748593 (1) (see all 7)
    shfm4 89.3 6 16688749 (1), 16724007 (1), 18515319 (1), 16691619 (1) (see all 5)
    ectrodactyly 88.6 29 14656652 (4), 11462173 (2), 15736220 (2), 11903230 (2) (see all 19)
    ectodermal dysplasia 88.6 55 11903230 (3), 18633439 (2), 12766194 (2), 20424325 (2) (see all 37)
    ankyloblepharon 88.5 12 16365259 (2), 19681128 (1), 16177572 (1), 18364388 (1) (see all 10)
    limb-mammary syndrome 85.8 5 11462173 (2), 14656652 (1), 11929852 (1), 17164413 (1)
    adult syndrome 82.3 22 11528512 (3), 16724007 (3), 19781362 (3), 11929852 (2) (see all 11)
    malformation foot 77.6 8 11462173 (2), 14656652 (1), 11595015 (1), 17224651 (1) (see all 5)
    limb malformation 73.8 4 19676060 (1), 16724007 (1), 17609671 (1), 17041931 (1)

    Genetic Association Database (GAD): TP63
    Human Genome Epidemiology (HuGE) Navigator: TP63 (17 documents)

    Export disorders for TP63 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TP63 gene, integrated from 10 sources (see all 1135):
    (articles sorted by number of sources associating them with TP63)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. (PubMed id 9774969)1, 2, 3, 9 Yang A.... McKeon F. (Mol. Cell 1998)
    2. A mutation of the p63 gene in non-syndromic cleft lip. (PubMed id 16740912)1, 2, 4, 9 Leoyklang P.... Shotelersuk V. (J. Med. Genet. 2006)
    3. Cloning and functional analysis of human p51, which structurally and functionally resembles p53. (PubMed id 9662378)1, 2, 3 Osada M.... Ikawa S. (Nat. Med. 1998)
    4. Transcriptional dysregulation of the p73L/p63/p51/p40/KET gene in human squamous cell carcinomas: expression of Delta Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51. (PubMed id 11336476)1, 2, 9 Senoo M.... Habu S. (Br. J. Cancer 2001)
    5. High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53. (PubMed id 11477076)1, 2, 9 Klein C.... Hansen S. (J. Biol. Chem. 2001)
    6. Mutation and expression of the p51 gene in human lung cancer. (PubMed id 10935472)1, 2, 9 Tani M....Yokota J. (Neoplasia 1999)
    7. p63 gene mutations in EEC syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype- phenotype correlation. (PubMed id 11462173)1, 2, 9 van Bokhoven H.... Brunner H.G. (Am. J. Hum. Genet. 2001)
    8. p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53. (PubMed id 10373484)1, 2, 9 Davison T.S....Arrowsmith C.H. (J. Biol. Chem. 1999)
    9. The p53 family member genes are involved in the Notch signal pathway. (PubMed id 11641404)1, 2, 9 Sasaki Y.... Tokino T. (J. Biol. Chem. 2002)
    10. A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism. (PubMed id 12446779)1, 2, 9 Serber Z.... Doetsch V. (Mol. Cell. Biol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8626 HGNC: 15979 AceView: TP73L Ensembl:ENSG00000073282 euGenes: HUgn8626
    ECgene: TP63 Kegg: 8626 H-InvDB: TP63

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TP63 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TP63 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=TP63[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TP63 gene:
    Search GeneIP for patents involving TP63

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TP63
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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