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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TP63 Gene

protein-coding   GIFtS: 66
GCID: GC03P189349

Tumor Protein P63

(Previous names: tumor protein p73-like, tumor protein p53-like, tumor protein...)
(Previous symbols: TP73L, TP53L, TP53CP)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Protein P631 2     OFC82 5
TP73L1 2 3 5     RHS2 5
KET2 3 5     SHFM42 5
TP53CP1 2     Tumor Protein P53-Like1
TP53L1 2     AIS2
Tumor Protein P53-Competing Protein1 2     B(p51A)2
Tumor Protein P73-Like1 3     B(p51B)2
Chronic Ulcerative Stomatitis Protein2 3     NBP2
Keratinocyte Transcription Factor KET2 3     Amplified In Squamous Cell Carcinoma2
Transformation-Related Protein 632 3     p53CP2
CUSP2 3     p73H2
p402 3     Tumor Protein 632
p512 3     Tumor Protein P63 DeltaN Isoform Delta2
p632 3     P633
p73L2 3     P73H3
EEC32 5     P73L3
LMS2 5     

External Ids:    HGNC: 159791   Entrez Gene: 86262   Ensembl: ENSG000000732827   OMIM: 6032735   UniProtKB: Q9H3D43   

Export aliases for TP63 gene to outside databases

Previous GC identifers: GC03P186351 GC03P190832 GC03P186752


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TP63 Gene:
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been
useful in defining the role this protein plays in the development and maintenance of stratified epithelial
tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such
as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium.
Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3);
split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome
(acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8.
Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding
different proteins. Many transcripts encoding different proteins have been reported but the biological validity
and the full-length nature of these variants have not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for TP63 Gene: 
TP63 (tumor protein p63) is a protein-coding gene. Diseases associated with TP63 include adult syndrome, and eec syndrome, and among its related super-pathways are Cell Cycle / Checkpoint Control and Development NOTCH1-mediated pathway for NF-KB activity modulation. GO annotations related to this gene include identical protein binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TP73.

UniProtKB/Swiss-Prot: P63_HUMAN, Q9H3D4
Function: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a
varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform
specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for
initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated
oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of
epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial
stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated
embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the
p21 promoter

Gene Wiki entry for TP63 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TP63 gene promoter:
         GR   GR-beta   p300   Lmo2   CUTL1   Evi-1   AREB6   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TP63 promoter sequence
   Search SABiosciences Chromatin IP Primers for TP63

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP63


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28   Ensembl cytogenetic band:  3q28   HGNC cytogenetic band: 3q27-q29

TP63 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP63 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P189349:  view genomic region     (about GC identifiers)

Start:
189,349,205 bp from pter      End:
189,615,068 bp from pter
Size:
265,864 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: P63_HUMAN, Q9H3D4 (See protein sequence)
Recommended Name: Tumor protein 63  
Size: 680 amino acids; 76785 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
Isoforms Alpha and Gamma interact with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity.
Isoform 1 and isoform 2 interact with WWP1. Interacts with PDS5A. Isoform 5 (via activation domain) interacts
with NOC2L
Subcellular location: Nucleus
Sequence caution: Sequence=AAF43486.1; Type=Erroneous initiation; Sequence=AAF43487.1; Type=Erroneous initiation;
Sequence=AAF43488.1; Type=Erroneous initiation; Sequence=AAF43489.1; Type=Erroneous initiation;
Sequence=AAF61624.1; Type=Frameshift; Positions=26; Sequence=BAA32592.1; Type=Frameshift; Positions=26;
Sequence=BAA32593.1; Type=Frameshift; Positions=26;
6/12 PDB 3D structures from and Proteopedia for TP63 (see all 12):
1RG6 (3D)        2RMN (3D)        2Y9T (3D)        2Y9U (3D)        3QYM (3D)        3QYN (3D)    
Secondary accessions: O75080 O75195 O75922 O76078 Q6VEG2 Q6VEG3 Q6VEG4 Q6VFJ1 Q6VFJ2 Q6VFJ3
Q6VH20 Q7LDI3 Q7LDI4 Q7LDI5 Q96KR0 Q9H3D2 Q9H3D3 Q9H3P8 Q9NPH7 Q9P1B4 Q9P1B5 Q9P1B6 Q9P1B7
Q9UBV9 Q9UE10 Q9UP26 Q9UP27 Q9UP28 Q9UP74
Alternative promoter usage, Alternative splicing: 12 isoforms:  Q9H3D4-1   Q9H3D4-2   Q9H3D4-3   Q9H3D4-4   Q9H3D4-5   Q9H3D4-6   Q9H3D4-7   Q9H3D4-8   
Q9H3D4-9   Q9H3D4-10   Q9H3D4-11   Q9H3D4-12   (Produced by alternative splicing of isoform 2. No experimental confirmation available. Variant in position: 6:N->H (in ADULT syndrome))

Explore the universe of human proteins at neXtProt for TP63: NX_Q9H3D4

Explore proteomics data for TP63 at MOPED 

Post-translational modifications:

  • UniProtKB: May be sumoylated (By similarity)
  • UniProtKB: Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H3D4

  • TP63 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TP63 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001108450.1  NP_001108451.1  NP_001108452.1  NP_001108453.1  NP_001108454.1  NP_003713.3  

    ENSEMBL proteins: 
     ENSP00000264731   ENSP00000407144   ENSP00000317510   ENSP00000376253   ENSP00000394337  
     ENSP00000346614   ENSP00000401661   ENSP00000392488   ENSP00000376256   ENSP00000376254  
     ENSP00000387839   ENSP00000389485   ENSP00000371495  

    Human Recombinant Protein Products for TP63: 
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    OriGene Protein Over-expression Lysate for TP63
    OriGene MassSpec for TP63 
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    Novus Biologicals TP63 Protein
    Sino Biological Recombinant Protein for TP63
    Sino Biological Cell Lysate for TP63 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TP63 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IBA--
    GO:0000790nuclear chromatin IDA--
    GO:0005634nucleus NAS9774969
    GO:0005654nucleoplasm IDA--
    GO:0005667transcription factor complex IBA--

    TP63 for ontologies           About GeneDecksing



    TP63 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TP63
    R&D Systems Antibodies for TP63 (p63/TP73L)
    Cell Signaling Technology (CST) Antibodies for TP63  (p63)
    OriGene Antibodies for TP63
    OriGene Custom Antibody Services for TP63
    GenScript Custom Superior Antibodies Services for TP63
    Abcam antibodies for TP63
    Cloud-Clone Corp. Antibodies for TP63 
    ThermoFisher Antibodies for TP63
    Search LSBio for Antibodies for TP63 

    Assay Products for TP63: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TP63
    R&D Systems Proteome Profiler Antibody Arrays for TP63 (p63/TP73L)
    GenScript Custom Assay Services for TP63
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TP63 
    Cloud-Clone Corp. CLIAs for TP63


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/8 InterPro protein domains (see all 8):
     IPR011615 p53_DNA-bd
     IPR012346 p53/RUNT-type_TF_DNA-bd
     IPR002117 p53_tumour_suppressor
     IPR013761 SAM/pointed
     IPR008967 p53-like_TF_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q9H3D4

    ProtoNet protein and cluster: Q9H3D4

    3 Blocks protein domains:
    IPB001660 Sterile alpha motif SAM
    IPB010991 p53
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: P63_HUMAN, Q9H3D4
    Domain: The transactivation inhibitory domain (TID) can interact with, and inhibit the activity of the N-terminal
    transcriptional activation domain of TA*-type isoforms
    Similarity: Belongs to the p53 family
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    TP63 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P63_HUMAN, Q9H3D4
    Function: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a
    varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform
    specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for
    initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated
    oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of
    epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial
    stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated
    embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the
    p21 promoter

         Genatlas biochemistry entry for TP63:
    TP63 homolog to TP53 and to TP73,highly expressed in the basal or progenitor layers of many epithelial
    tissues,encoding six isoforms transcribed from two promoters,one yielding,the other lacking a transactivation
    domain (respectively TA-p63,Delta N-p63),combined with alternative splicing producing the isotypes
    alpha,beta,gamma,playing a critical in the maintenance of the progenitor-cell populations necessary to sustain
    epithelial development and morphogenesis

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0002039p53 binding IBA--
    GO:0003677DNA binding NAS9662346
    GO:0003682chromatin binding IDA--
    GO:0003684damaged DNA binding IBA--
         
    TP63 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TP63:
     Increased ID2::GFP protein exp  Increased gamma-H2AX phosphory 

         15/22 MGI mutant phenotypes (inferred from 13 alleles(MGI details for Trp63) (see all 22):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  mortality/aging  muscle  normal 

    TP63 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TP63: Trp63tm2Brd Trp63tm1Fmc Trp63tm3.2Brd Trp63tm1Brd Trp63tm2Fmc Trp63tm1.1Elrf

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TP63 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TP63

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TP63 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TP63 

    miRNA
    Products:
        
    miRTarBase miRNAs that target TP63:
    hsa-mir-203 (MIRT004248), hsa-mir-21 (MIRT005329), hsa-mir-92a (MIRT004281)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TP63
    8/70 QIAGEN miScript miRNA Assays for microRNAs that regulate TP63 (see all 70):
    hsa-miR-520e hsa-miR-218-1* hsa-miR-578 hsa-miR-519a hsa-miR-3921 hsa-miR-149 hsa-miR-4325 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidTP63 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TP63
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TP63

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TP63
    Sirion Biotech Customized adenovirus for overexpression of TP63

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TP63 (see all 46)
    OriGene ORF clones in mouse, rat for TP63
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): TP63 (NM_003722)
    Sino Biological Human cDNA Clone for TP63
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TP63
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP63
    Sirion Biotech Customized lentivirus for stable overexpression of TP63 
                         Customized lentivirus expression plasmids for stable overexpression of TP63 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TP63
    Search LifeMap BioReagents cell lines for TP63
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP63


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TP63 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1DNA Damage
    DNA Damage0.32
    Cell Cycle / Checkpoint Control0.32
    2Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development Notch Signaling Pathway0.54
    3Apoptosis Modulation and Signaling
    Apoptosis0.38
    4TP53 network
    TP53 network
    5MicroRNAs in cancer
    MicroRNAs in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TP63
        Development Notch Signaling Pathway


    2 Cell Signaling Technology (CST) Pathways for TP63
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 GeneGo (Thomson Reuters) Pathway for TP63
        Development Notch Signaling Pathway

    3 BioSystems Pathways for TP63
        Apoptosis
    TP53 network
    Direct p53 effectors



    1         Kegg Pathway  (Kegg details for TP63):
        MicroRNAs in cancer


    TP63 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TP63

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/121 Interacting proteins for TP63 (Q9H3D41, 2, 3 ENSP000002647314) via UniProtKB, MINT, STRING, and/or I2D (see all 121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SATB2Q9UPW62, 3, ENSP000002609264MINT-8040599 MINT-8040614 MINT-8040583 MINT-8040535 MINT-8044440 MINT-8040642 MINT-8040525 MINT-8040627 I2D: score=1 STRING: ENSP00000260926
    TP53P046371, 3, ENSP000002693054EBI-2337775,EBI-366083 I2D: score=5 STRING: ENSP00000269305
    SMAD2Q157961, 3, ENSP000002621604EBI-2337775,EBI-1040141 I2D: score=1 STRING: ENSP00000262160
    CABLES1Q8TDN42, 3, ENSP000002569254MINT-7988829 MINT-7988887 MINT-7988815 MINT-7988867 MINT-7988849 MINT-7988907 MINT-7988919 I2D: score=1 STRING: ENSP00000256925
    PPP1R13BQ96KQ42, 3, ENSP000002025564MINT-45876 MINT-45877 I2D: score=3 STRING: ENSP00000202556
    About this table

    Gene Ontology (GO): 5/57 biological process terms (GO ID links to tree view) (see all 57):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IBA--
    GO:0001501skeletal system development IEA--
    GO:0001736establishment of planar polarity IEA--
    GO:0001738morphogenesis of a polarized epithelium ----
    GO:0001942hair follicle development ----

    TP63 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TP63 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TP63 (P63)

    10/27 Novoseek inferred chemical compound relationships for TP63 gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    noxa 55.3 4 20195489 (1), 16363065 (1), 16413463 (1)
    dmso 51.2 33 15922574 (3), 16884378 (3), 16319057 (2), 19700772 (2) (see all 18)
    hematoxylin 49.9 5 16138374 (1), 12760288 (1), 15832080 (1), 17927587 (1) (see all 5)
    mucicarmine 43.1 2 11136565 (1), 11023104 (1)
    estrogen 40 27 12653579 (2), 16625090 (1), 17214855 (1), 20222992 (1) (see all 23)
    progesterone 36.5 21 14693844 (1), 16241993 (1), 16625090 (1), 20222992 (1) (see all 20)
    2-methoxyethanol 35.5 6 12811858 (4), 15762278 (1)
    paraffin 34.5 11 19877114 (1), 17285325 (1), 17912630 (1), 18619959 (1) (see all 11)
    b 723 32.3 5 16415794 (3), 14652817 (1), 17515511 (1)
    bromodeoxyuridine 18.8 15 19122469 (5), 19034133 (3), 16424398 (1), 16123387 (1)

    Search CenterWatch for drugs/clinical trials and news about TP63 / P63

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TP63 gene (6 alternative transcripts): 
    NM_001114978.1  NM_001114979.1  NM_001114980.1  NM_001114981.1  NM_001114982.1  NM_003722.4  

    Unigene Cluster for TP63:

    Tumor protein p63
    Hs.137569  [show with all ESTs]
    Unigene Representative Sequence: BC039815
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486398 ENST00000264731(uc003fry.2 uc003frz.2 uc010hzc.1)
    ENST00000418709(uc003frx.2) ENST00000320472 ENST00000392460 ENST00000440651
    ENST00000354600(uc003fsc.2 uc003fsd.2 uc021xir.1 uc010hzd.1)
    ENST00000434928 ENST00000460036(uc003fsa.2) ENST00000437221(uc003fsb.2)
    ENST00000392463 ENST00000392461 ENST00000449992 ENST00000456148(uc003fse.1)
    ENST00000382063
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TP63
    8/70 QIAGEN miScript miRNA Assays for microRNAs that regulate TP63 (see all 70):
    hsa-miR-520e hsa-miR-218-1* hsa-miR-578 hsa-miR-519a hsa-miR-3921 hsa-miR-149 hsa-miR-4325 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidTP63 3' UTR sequence
    Inhib. RNA
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    OriGene ORF clones in mouse, rat for TP63
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    GenScript: all cDNA clones in your preferred vector (see all 6): TP63 (NM_003722)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TP63
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP63
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    Additional mRNA sequence: 

    AB010153.1 AB016072.1 AB042841.1 AF075428.1 AF075429.1 AF075430.1 AF075431.1 AF075432.1 
    AF075433.1 AF091627.1 AF116771.1 AJ315499.1 AK304127.1 BC039815.1 GQ202689.1 GQ202690.1 
    Y16961.1 

    9 DOTS entries:

    DT.113716  DT.95374522  DT.75166481  DT.95374523  DT.100767943  DT.100767944  DT.100767942  DT.91857800 
    DT.95374521 

    24/132 AceView cDNA sequences (see all 132):

    AI377044 AI332920 AL698768 BQ045216 AB042841 AF075430 W76490 BM083305 
    BQ027589 AF075428 BX103828 AL698769 BC039815 BX447464 AF075429 AI127157 
    AB016072 BG676240 AA455929 AA025687 BX504901 AF075432 AI122593 NM_003722 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TP63 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d
    SP1:                          -     -     -     -           -                                         -     -     -                                             
    SP2:                                                        -                                         -     -     -                                             
    SP3:                          -     -     -     -           -                                         -     -     -           -     -                           
    SP4:                                                  -     -                                         -     -     -                                             
    SP5:                          -     -     -     -           -                                         -                                                         


    ECgene alternative splicing isoforms for TP63

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TP63 expression in normal human tissues (normalized intensities)      TP63 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATAAAATT
    TP63 Expression
    About this image


    TP63 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Epithelium
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Lung (Respiratory System)    fully expand to see all 9 entries
             Trachea Progenitor Cells Trachea
             Mature airway epithelial cells ( Directed differentiation of human embryonic stem...
             bronchus ; respiratory epithelial cells   
     
     Epidermis (Integumentary System)    fully expand to see all 8 entries
             Intermediate Keratinocytes Embryonic Epidermis
             Stratified Epidermis
             Human EpiDermal Keratinocytes (HEK)   
     
     Eye (Sensory Organs)    fully expand to see all 7 entries
             Limbal epithelial stem cells
             Human Corneal Epithelial Cells (HCEpiC)   
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             visceral organ/oral region/upper jaw   

    See TP63 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TP63

    SOURCE GeneReport for Unigene cluster: Hs.137569

    UniProtKB/Swiss-Prot: P63_HUMAN, Q9H3D4
    Tissue specificity: Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and
    thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye
    and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous
    cell carcinomas, but not in normal skin tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including TP63: 
              Cell Cycle in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TP63 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trp631 , 5 transformation related protein 631, 5 91.27(n)1
    97.94(a)1
      16 (17.37 cM)5
    220611  NM_001127259.11  NP_001120731.11 
     256837635 
    chicken
    (Gallus gallus)
    Aves TP631 tumor protein p63 84.8(n)
    96.48(a)
      374269  NM_204351.1  NP_989682.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    TP636
    Uncharacterized protein
    84(a)
    70(a)
    possible ortholog
    1 ↔ 1
    GL343360.1(1238800-1240541)
    GL343386.1(24198-69112)
    African clawed frog
    (Xenopus laevis)
    Amphibia tp73l-A2 p63 DNA binding protein/tumor protein p73-like 79.27(n)    AF314148.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tp73l2 tumor protein p73-like 79.47(n)   260407  AF487944.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta p536
    p53
    16(a)
    1 → many
    3R(18875379-18879804)


    ENSEMBL Gene Tree for TP63 (if available)
    TreeFam Gene Tree for TP63 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TP63 gene
    TP732  TP532  
    18/26 SIMAP similar genes for TP63 using alignment to 4 protein entries:     P63_HUMAN (see all proteins) (see all similar genes):
    RHOA    FLJ00047    KIAA0101    SNRPF    C12orf76    COQ5
    p53    HC6    TP73    RBP7    GALK2    GEMIN6
    PFKFB3    SH2B3    TP53    pp12301    FP6778    LOC100996426

    TP63 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5829 SNPs in TP63 are shown (see all 5829)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0351294
    Ectodermal dysplasia, Rapp-Hodgkin type (EDRH)4--see VAR_0351292 S P mis40--------
    VAR_0208794
    Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC)4--see VAR_0208792 L F mis40--------
    VAR_0208714
    Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)4--see VAR_0208712 R W mis40--------
    VAR_0208724
    Colon cancer4--see VAR_0208722 P H mis40--------
    VAR_0208774
    Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)4--see VAR_0208772 C R mis40--------
    VAR_0327384
    Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)4--see VAR_0327382 R Q mis40--------
    VAR_0208704
    Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)4--see VAR_0208702 R Q mis40--------
    VAR_0327414
    Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)4--see VAR_0327412 R C mis40--------
    VAR_0327404
    Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)4--see VAR_0327402 S N mis40--------
    VAR_0327394
    Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)4--see VAR_0327392 C Y mis40--------

    HapMap Linkage Disequilibrium report for TP63 (189349205 - 189599205 bp, first 250kb of TP63)

    Structural Variations
         Database of Genomic Variants (DGV) 10/38 variations for TP63 (see all 38):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv436370CNV Deletion17901297
    esv2656594CNV Deletion23128226
    esv2289340CNV Deletion18987734
    esv2476340CNV Deletion19546169
    esv2222823CNV Deletion18987734
    esv1003991CNV Deletion20482838
    esv2305625CNV Deletion18987734
    esv2726369CNV Deletion23290073
    esv2726367CNV Deletion23290073
    esv2726368CNV Deletion23290073


    Human Gene Mutation Database (HGMD): TP63

    Locus Specific Mutation Databases (LSDB): TP63
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TP63
    DNA2.0 Custom Variant and Variant Library Synthesis for TP63

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603273   
    OMIM disorders: 604292  605289  106260  103285  603543  129400  
    UniProtKB/Swiss-Prot: P63_HUMAN, Q9H3D4
  • Acro-dermato-ungual-lacrimal-tooth syndrome (ADULT syndrome) [MIM:103285]: A form of ectodermal
    dysplasia. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or
    more ectodermal structures. ADULT syndrome involves ectrodactyly, syndactyly, finger- and toenail dysplasia,
    hypoplastic breasts and nipples, intensive freckling, lacrimal duct atresia, frontal alopecia, primary hypodontia
    and loss of permanent teeth. ADULT syndrome differs significantly from EEC3 syndrome by the absence of facial
    clefting. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) [MIM:106260]: An autosomal dominant condition
    characterized by congenital ectodermal dysplasia with coarse, wiry, sparse hair, dystrophic nails, slight
    hypohidrosis, scalp infections, ankyloblepharon filiform adnatum, maxillary hypoplasia, hypodontia and cleft
    lip/palate. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3) [MIM:604292]: A form of
    ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal
    structures. It is an autosomal dominant syndrome characterized by ectrodactyly of hands and feet, ectodermal
    dysplasia and facial clefting. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • Split-hand/foot malformation 4 (SHFM4) [MIM:605289]: A limb malformation involving the central rays of
    the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of
    the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal
    and craniofacial findings, and orofacial clefting. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Limb-mammary syndrome (LMS) [MIM:603543]: Characterized by ectrodactyly, cleft palate and mammary-gland
    abnormalities. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Note=Defects in TP63 are a cause of cervical, colon, head and neck, lung and ovarian cancers
  • Ectodermal dysplasia, Rapp-Hodgkin type (EDRH) [MIM:129400]: A form of ectodermal dysplasia, a
    heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Characterized
    by the combination of anhidrotic ectodermal dysplasia, cleft lip, and cleft palate. The clinical syndrome is
    comprised of a characteristic facies (narrow nose and small mouth), wiry, slow-growing, and uncombable hair,
    sparse eyelashes and eyebrows, obstructed lacrimal puncta/epiphora, bilateral stenosis of external auditory
    canals, microsomia, hypodontia, cone-shaped incisors, enamel hypoplasia, dystrophic nails, and cleft lip/cleft
    palate. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Non-syndromic orofacial cleft 8 (OFC8) [MIM:129400]: A birth defect consisting of cleft lips with or
    without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on
    one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip
    extending into the floor of the nostril and involving the upper gum. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 20/172 diseases for TP63 (see all 172):    About MalaCards
    adult syndrome    eec syndrome    rapp-hodgkin syndrome    split hand foot malformation
    ankyloblepharon-ectodermal defects-cleft lip/palate syndrome    intraductal papilloma    limb-mammary syndrome    epidermal appendage tumor
    stomatitis    chand syndrome    ulcerative stomatitis    dermoid cyst of ovary
    ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3    tp63-related disorders    exstrophy of the bladder    split-hand/foot malformation, type 4
    orofacial cleft 8    cleft lip    orofacial cleft    ameloblastic carcinoma

    5 diseases from the University of Copenhagen DISEASES database for TP63:
    Cleft lip     ADULT syndrome     Leiomyosarcoma     Ulcerative stomatitis
    Syndactyly

    TP63 for disorders           About GeneDecksing

    10/97 Novoseek inferred disease relationships for TP63 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aec syndrome 93.4 30 19676060 (2), 12766194 (2), 11159940 (2), 16365259 (2) (see all 20)
    rapp-hodgkin syndrome 90.7 10 15725251 (2), 12939657 (2), 12766194 (1), 15748593 (1) (see all 7)
    shfm4 89.3 6 16688749 (1), 16724007 (1), 18515319 (1), 16691619 (1) (see all 5)
    ectrodactyly 88.6 29 14656652 (4), 11462173 (2), 15736220 (2), 11903230 (2) (see all 19)
    ectodermal dysplasia 88.6 55 11903230 (3), 18633439 (2), 12766194 (2), 20424325 (2) (see all 37)
    ankyloblepharon 88.5 12 16365259 (2), 19681128 (1), 16177572 (1), 18364388 (1) (see all 10)
    limb-mammary syndrome 85.8 5 11462173 (2), 14656652 (1), 11929852 (1), 17164413 (1)
    adult syndrome 82.3 22 11528512 (3), 16724007 (3), 19781362 (3), 11929852 (2) (see all 11)
    malformation foot 77.6 8 11462173 (2), 14656652 (1), 11595015 (1), 17224651 (1) (see all 5)
    limb malformation 73.8 4 19676060 (1), 16724007 (1), 17609671 (1), 17041931 (1)

    Genetic Association Database (GAD): TP63
    Human Genome Epidemiology (HuGE) Navigator: TP63 (17 documents)

    Export disorders for TP63 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TP63 gene, integrated from 9 sources (see all 1104):
    (articles sorted by number of sources associating them with TP63)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. (PubMed id 9774969)1, 2, 3, 9 Yang A.... McKeon F. (1998)
    2. A mutation of the p63 gene in non-syndromic cleft lip. (PubMed id 16740912)1, 2, 4, 9 Leoyklang P.... Shotelersuk V. (2006)
    3. Cloning and functional analysis of human p51, which structurally and functionally resembles p53. (PubMed id 9662378)1, 2, 3 Osada M....Ikawa S. (1998)
    4. Transcriptional dysregulation of the p73L/p63/p51/p40/KET gene in human squamous cell carcinomas: expression of Delta Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51. (PubMed id 11336476)1, 2, 9 Senoo M.... Habu S. (2001)
    5. High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53. (PubMed id 11477076)1, 2, 9 Klein C.... Hansen S. (2001)
    6. Mutation and expression of the p51 gene in human lung cancer. (PubMed id 10935472)1, 2, 9 Tani M....Yokota J. (1999)
    7. p63 gene mutations in EEC syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype- phenotype correlation. (PubMed id 11462173)1, 2, 9 van Bokhoven H.... Brunner H.G. (2001)
    8. p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53. (PubMed id 10373484)1, 2, 9 Davison T.S....Arrowsmith C.H. (1999)
    9. The p53 family member genes are involved in the Notch signal pathway. (PubMed id 11641404)1, 2, 9 Sasaki Y.... Tokino T. (2002)
    10. A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism. (PubMed id 12446779)1, 2, 9 Serber Z.... Doetsch V. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8626 HGNC: 15979 AceView: TP73L Ensembl:ENSG00000073282 euGenes: HUgn8626
    ECgene: TP63 Kegg: 8626 H-InvDB: TP63

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TP63 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TP63 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TP63

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TP63 gene:
    Search GeneIP for patents involving TP63

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     Antibodies & Assays for TP63  (p63)

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     Search Chromatin IP Primers for TP63
     RT2 qPCR Primer Assay in human, mouse, rat TP63
     GNC Network for TP63
     SABiosciences PCR Arrays including human, mouse, rat TP63
     Search Tocris compounds for TP63 (P63)
     Proteins and Antibodies for TP63
     Cell Lysates for TP63
     cDNA Clones for TP63
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
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     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TP63 proteins
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     See all of Abcam's Antibodies, Kits and Proteins for TP63
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     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TP63
     Antibodies for TP63
     ELISAs for TP63
     CLIAs for TP63
     Search LifeMap BioReagents cell lines for TP63
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP63
     SwitchGear 3'UTR luciferase reporter plasmids for TP63
     SwitchGear Promoter luciferase reporter plasmids for TP63
     ThermoFisher Antibodies for TP63
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP63
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TP63
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TP63
    Customized:
     lentivirus for stable overexpression of TP63
     lentivirus expression plasmids for stable overexpression of TP63
     adenovirus for overexpression of TP63
     Search LSBio for Antibodies for TP63
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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