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Aliases for TP53TG5 Gene

Aliases for TP53TG5 Gene

  • TP53 Target 5 2 3
  • TP53-Inducible Gene 5 Protein 3 4
  • C20orf10 3 4
  • Chromosome 20 Open Reading Frame 10 2
  • TP53-Target Gene 5 Protein 3
  • CLG01 3

External Ids for TP53TG5 Gene

Previous Symbols for TP53TG5 Gene

  • C20orf10

Summaries for TP53TG5 Gene

GeneCards Summary for TP53TG5 Gene

TP53TG5 (TP53 Target 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TP53TG5 Gene

  • May play a significant role in p53/TP53-mediating signaling pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP53TG5 Gene

Genomics for TP53TG5 Gene

Genomic Location for TP53TG5 Gene

Start:
45,372,563 bp from pter
End:
45,407,889 bp from pter
Size:
35,327 bases
Orientation:
Minus strand

Genomic View for TP53TG5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TP53TG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53TG5 Gene

Regulatory Elements for TP53TG5 Gene

Proteins for TP53TG5 Gene

  • Protein details for TP53TG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2B4-T53G5_HUMAN
    Recommended name:
    TP53-target gene 5 protein
    Protein Accession:
    Q9Y2B4
    Secondary Accessions:

    Protein attributes for TP53TG5 Gene

    Size:
    290 amino acids
    Molecular mass:
    34019 Da
    Quaternary structure:
    • Interacts with p53/TP53.

neXtProt entry for TP53TG5 Gene

Proteomics data for TP53TG5 Gene at MOPED

Post-translational modifications for TP53TG5 Gene

No Post-translational modifications

Other Protein References for TP53TG5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TP53TG5 Gene

Domains for TP53TG5 Gene

Protein Domains for TP53TG5 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with TP53TG5: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TP53TG5 Gene

Function for TP53TG5 Gene

Molecular function for TP53TG5 Gene

UniProtKB/Swiss-Prot Function: May play a significant role in p53/TP53-mediating signaling pathway.
UniProtKB/Swiss-Prot Induction: By p53/TP53, UV irradiation, by hydrogen peroxide treatment or by treatment with a DNA-damaging reagent.

Gene Ontology (GO) - Molecular Function for TP53TG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TP53TG5: view

miRNA for TP53TG5 Gene

miRTarBase miRNAs that target TP53TG5

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TP53TG5 Gene

Localization for TP53TG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP53TG5 Gene

Cytoplasm. Nucleus. Note=Cell cycle dependent intracellular localization.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TP53TG5 Gene COMPARTMENTS Subcellular localization image for TP53TG5 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TP53TG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TP53TG5: view

Pathways for TP53TG5 Gene

SuperPathways for TP53TG5 Gene

No Data Available

Interacting Proteins for TP53TG5 Gene

Selected Interacting proteins: Q9Y2B4-T53G5_HUMAN for TP53TG5 Gene via I2D

Symbol External ID(s) Details
HIF1A
WDR45

Gene Ontology (GO) - Biological Process for TP53TG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030308 negative regulation of cell growth NAS 10719363
GO:0035556 intracellular signal transduction NAS 10719363
genes like me logo Genes that share ontologies with TP53TG5: view

No data available for Pathways by source for TP53TG5 Gene

Compounds for TP53TG5 Gene

(15) ApexBio Compounds for TP53TG5 Gene

Compound Action Cas Number
AMG232 potent and selective piperidinone inhibitor of the MDM2-p53 interaction.
CP 31398 dihydrochloride p53 stabilizing agent. [1217195-61-3]
JNJ-26854165 (Serdemetan) p53 activator, blocking Mdm2-p53 interaction [881202-45-5]
Nutlin-3 inhibitor of the MDM2/p53 interaction [890090-75-2]
Nutlin-3a chiral inhibits the MDM2-p53 interaction and activates p53. [675576-98-4]
p53 and MDM2 proteins-interaction-inhibitor chiral inhibitor of the interaction between p53 and MDM2 proteins. [939981-37-0]
Pifithrin-miu Inhibits p53 binding to mitochondria. [64984-31-2]
PRIMA-1 Cell-permeable BAX inhibitor, restore p53 activity [5608-24-2]
PRIMA-1MET Cell-permeable BAX inhibitor, restore p53 activity [5291-32-7]
RG7112 Restoration of p53 activity by inhibiting the p53-MDM2 interaction. [939981-39-2]
RG7388 Blocking the MDM2-p53 interaction stabilizes p53. [1229705-06-9]
RITA (NSC 652287) Cell-permeable antitumor agent, blocking Mdm2-p53 interaction and p53 ubiquitination [213261-59-7]
SJ 172550 Inhibits the MDMX-p53 interaction in cultured retinoblastoma cells. [431979-47-4]
Tenovin-1 Cell-permeable, reversible SIRT2 inhibitor, activates p53 [380315-80-0]
Tenovin-3 Tenovin-3 [1011301-27-1]
genes like me logo Genes that share compounds with TP53TG5: view

Transcripts for TP53TG5 Gene

mRNA/cDNA for TP53TG5 Gene

(6) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TP53TG5 Gene

TP53 target 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TP53TG5 Gene

No ASD Table

Relevant External Links for TP53TG5 Gene

GeneLoc Exon Structure for
TP53TG5
ECgene alternative splicing isoforms for
TP53TG5

Expression for TP53TG5 Gene

mRNA expression in normal human tissues for TP53TG5 Gene

mRNA differential expression in normal tissues according to GTEx for TP53TG5 Gene

This gene is overexpressed in Testis (10.2), Brain - Spinal cord (cervical c-1) (6.2), and Brain - Substantia nigra (4.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TP53TG5 Gene

SOURCE GeneReport for Unigene cluster for TP53TG5 Gene Hs.710271

mRNA Expression by UniProt/SwissProt for TP53TG5 Gene

Q9Y2B4-T53G5_HUMAN
Tissue specificity: Highly expressed in heart, brain and small intestine. Less abundant in skeletal muscle, spleen, prostate, ovary and colon. A smaller transcript is expressed specifically in the testis.
genes like me logo Genes that share expressions with TP53TG5: view

Orthologs for TP53TG5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TP53TG5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TP53TG5 36
  • 99.2 (n)
  • 97.93 (a)
TP53TG5 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TP53TG5 36
  • 76.47 (n)
  • 61.76 (a)
TP53TG5 37
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TP53TG5 36
  • 77.96 (n)
  • 66.94 (a)
TP53TG5 37
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trp53tg5 36
  • 71.85 (n)
  • 57.98 (a)
Trp53tg5 16
Trp53tg5 37
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TP53TG5 37
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TP53TG5 37
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tp53tg5 36
  • 71.51 (n)
  • 56.43 (a)
Species with no ortholog for TP53TG5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TP53TG5 Gene

ENSEMBL:
Gene Tree for TP53TG5 (if available)
TreeFam:
Gene Tree for TP53TG5 (if available)

Paralogs for TP53TG5 Gene

No data available for Paralogs for TP53TG5 Gene

Variants for TP53TG5 Gene

Sequence variations from dbSNP and Humsavar for TP53TG5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
VAR_051397 -
VAR_051398 -
VAR_051399 -
VAR_051400 -
VAR_051401 -

Relevant External Links for TP53TG5 Gene

HapMap Linkage Disequilibrium report
TP53TG5

No data available for Structural Variations from Database of Genomic Variants (DGV) for TP53TG5 Gene

Disorders for TP53TG5 Gene

No disorders were found for TP53TG5 Gene.

No data available for UniProtKB/Swiss-Prot for TP53TG5 Gene

Publications for TP53TG5 Gene

  1. Isolation and characterization of a novel TP53-inducible gene, TP53TG5, which suppresses growth and shows cell cycle-dependent transition of expression. (PMID: 10719363) Isaka S. … Nakamura Y. (Genes Chromosomes Cancer 2000) 3 4 23
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for TP53TG5 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate TP53TG5
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TP53TG5
    • Block miRNA regulation of TP53TG5 using miScript Target Protectors

    Sources for TP53TG5 Gene

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