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TP53TG3D Gene

protein-coding   GIFtS: 24
GCID: GC16P032266

TP53 Target 3D

  Search for TP53TG3D
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TP53 Target 3D1 2     TP53TG3C2
TP53-Inducible Gene 3 Protein2 3     TP53-Target Gene 3 Protein2
TP53TG32     TP53TG3A3
TP53TG3B2     

External Ids:    HGNC: 446571   Entrez Gene: 7292642   Ensembl: ENSG000002054567   UniProtKB: Q9ULZ03   

Export aliases for TP53TG3D gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TP53TG3D Gene:
TP53TG3D (TP53 target 3D) is a protein-coding gene. An important paralog of this gene is TP53TG3B.

UniProtKB/Swiss-Prot: T53G3_HUMAN, Q9ULZ0
Function: May play a significant role in p53/TP53-mediating signaling pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_187260.1  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TP53TG3D
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTP53TG3D promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TP53TG3D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

TP53TG3D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP53TG3D gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P032266:  view genomic region     (about GC identifiers)

Start:
32,264,040 bp from pter      End:
32,267,243 bp from pter
Size:
3,204 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TP53TG3D

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: T53G3_HUMAN, Q9ULZ0 (See protein sequence)
Recommended Name: TP53-target gene 3 protein  
Size: 132 amino acids; 13627 Da
Secondary accessions: B2R5K6 Q4KN31 Q9ULY9
Alternative splicing: 3 isoforms:  Q9ULZ0-1   Q9ULZ0-2   Q9ULZ0-3   

Explore the universe of human proteins at neXtProt for TP53TG3D: NX_Q9ULZ0

REFSEQ proteins: NP_001230651.1  
ENSEMBL proteins: 
 ENSP00000455596   ENSP00000454398   ENSP00000457079   ENSP00000458008   ENSP00000458552  
 ENSP00000454339  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q9ULZ0


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: T53G3_HUMAN, Q9ULZ0
Function: May play a significant role in p53/TP53-mediating signaling pathway
Induction: By p53/TP53

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
T53G3_HUMAN, Q9ULZ0: Cytoplasm. Nucleus

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus ----
GO:0005737cytoplasm ----

TP53TG3D for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TP53TG3D
Interactions:

    Search GeneGlobe Interaction Network for TP53TG3D

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for TP53TG3D (T53G3)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TP53TG3D gene: 
NM_001243722.2  

Unigene Cluster for TP53TG3D:

TP53 target 3D
Hs.513537  [show with all ESTs]
Unigene Representative Sequence: AB023509
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000398664 ENST00000380148(uc021tgy.1 uc002ecy.3) ENST00000569631
ENST00000563025 ENST00000568044 ENST00000564810 ENST00000567978 ENST00000354614

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Additional mRNA sequence: 

AB023509.1 BC096700.1 BC099842.1 CR541650.1 

10 DOTS entries:

DT.100734283  DT.97813492  DT.121635888  DT.100765259  DT.120659507  DT.454757  DT.97772458  DT.120659501 
DT.120715617  DT.95365457 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

TP53TG3D Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.513537

UniProtKB/Swiss-Prot: T53G3_HUMAN, Q9ULZ0
Tissue specificity: Strongly expressed in testis. Weakly expressed in heart, placenta and skeletal muscle

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for TP53TG3D gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia LOC7498151 TP53-target gene 3 protein-like 97.55(n)
98.17(a)
  749815  XM_003318082.1  XP_003318130.1 


ENSEMBL Gene Tree for TP53TG3D (if available)
TreeFam Gene Tree for TP53TG3D (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TP53TG3D gene
TP53TG31 2  TP53TG3B1 2  LOC102723713  TP53TG3C1 2  
3 SIMAP similar genes for TP53TG3D using alignment to 2 protein entries:     T53G3_HUMAN (see all proteins):
TP53TG3B    TP53TG3C    TP53TG3

TP53TG3D for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TP53TG3D (see all 37)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1493578811,2
C--32265022(+) TCCGCC/GGCAGG 2 A syn10--------
rs1874237091,2
--32265599(+) ATCCCC/TTCGAG 1 -- int10--------
rs620435591,2
C,F--32265727(+) CAAATT/CCTCTG 1 -- int13Minor allele frequency- C:0.15NA WA EU 217
rs712643621,2
--32265744(-) GCGGCG/ACTCCT 1 -- int11Minor allele frequency- A:0.50NA 2
rs1383073021,2
C--32265903(+) CCTGGA/GAGCTG 1 -- int10--------
rs2010706331,2
C--32265959(+) CTTCC-/AGGCCT 1 -- int10--------
rs3737369711,2
C--32266379(+) AAGGTA/GAGAAT 1 -- ut310--------
rs1472778001,2
--32266543(+) CCTGCC/TTGCTG 1 -- ut310--------
rs1925460301,2
C--32266593(+) TGTACC/TTTTGT 1 -- ut310--------
rs1850691341,2
--32266596(+) ACTTTC/TGTGGG 1 -- ut310--------

HapMap Linkage Disequilibrium report for TP53TG3D (32264040 - 32267243 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TP53TG3D: --
Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TP53TG3D gene integrated from 10 sources:
(articles sorted by number of sources associating them with TP53TG3D)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. Isolation and characterization of a novel TP53-inducible gene, TP53TG3. (PubMed id 10534768)2 Ng C.C.... Nakamura Y. (Genes Chromosomes Cancer 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 729264 HGNC: 44657 Ensembl:ENSG00000205456 euGenes: HUgn729264 ECgene: TP53TG3D
H-InvDB: TP53TG3D

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TP53TG3D Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TP53TG3D gene:
Search GeneIP for patents involving TP53TG3D

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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