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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TP53TG3 Gene

protein-coding   GIFtS: 36
GCID: GC16M032684

TP53 Target 3

  Search for TP53TG3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TP53 Target 31 2
P53 Target Gene 31 2
TP53TG3A2 3
TP53-Inducible Gene 3 Protein2 3
P53TG32
TP53-Target Gene 3 Protein2

External Ids:    HGNC: 307591   Entrez Gene: 241502   Ensembl: ENSG000001836327   UniProtKB: Q9ULZ03   

Export aliases for TP53TG3 gene to outside databases

Previous GC identifers: GC16P032118 GC16P033256 GC16M032682 GC16M032721 GC16P032172 GC16M032590


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TP53TG3 Gene: 
TP53TG3 (TP53 target 3) is a protein-coding gene. An important paralog of this gene is TP53TG3B.

UniProtKB/Swiss-Prot: T53G3_HUMAN, Q9ULZ0
Function: May play a significant role in p53/TP53-mediating signaling pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TP53TG3 gene promoter:
         HFH-3   AML1a   NF-YA   GATA-2   GATA-1   FOXI1   NF-YB   CBF-B   CP1A   NF-Y   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTP53TG3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TP53TG3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP53TG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p13

TP53TG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP53TG3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M032684:  view genomic region     (about GC identifiers)

Start:
32,684,849 bp from pter      End:
32,688,053 bp from pter
Size:
3,205 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: T53G3_HUMAN, Q9ULZ0 (See protein sequence)
Recommended Name: TP53-target gene 3 protein  
Size: 132 amino acids; 13627 Da
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: B2R5K6 Q4KN31 Q9ULY9
Alternative splicing: 3 isoforms:  Q9ULZ0-1   Q9ULZ0-2   Q9ULZ0-3   

Explore the universe of human proteins at neXtProt for TP53TG3: NX_Q9ULZ0

Explore proteomics data for TP53TG3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9ULZ0

  • TP53TG3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TP53TG3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001254742.1  NP_057296.1  

    ENSEMBL proteins: 
     ENSP00000455448   ENSP00000381672   ENSP00000459299   ENSP00000457452   ENSP00000381670  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----

    TP53TG3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9ULZ0


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T53G3_HUMAN, Q9ULZ0
    Function: May play a significant role in p53/TP53-mediating signaling pathway
    Induction: By p53/TP53

    Phenotypes:
         1 GenomeRNAi human phenotype for TP53TG3:

     Increased S DNA content 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TP53TG3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TP53TG3 (ENSP000003816724) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TP53TG3 (T53G3)

    Search CenterWatch for drugs/clinical trials and news about TP53TG3 / T53G3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TP53TG3 gene (3 alternative transcripts): 
    NM_015369.1  NM_001267813.1  NM_016212.3  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000565622(uc021thb.1) ENST00000398682(uc002edd.3 uc002ede.3)
    ENST00000563102 ENST00000569420 ENST00000563658 ENST00000568854 ENST00000562021
    ENST00000564154 ENST00000398680
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    24/28 AceView cDNA sequences (see all 28):

    AL133588 AW594172 BM554064 CA425760 CA417872 BV179688 BX381390 BX370038 
    NM_015369 BV188304 AI214898 BV188965 AA993103 BX370039 AI208123 AA557322 
    AB023508 BG721667 N64770 N76182 BI459395 BI560253 BI825431 BI561719 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TP53TG3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TP53TG3 Expression
    About this image


    See TP53TG3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TP53TG3

    UniProtKB/Swiss-Prot: T53G3_HUMAN, Q9ULZ0
    Tissue specificity: Strongly expressed in testis. Weakly expressed in heart, placenta and skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53TG3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for TP53TG3 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia LOC7454511 TP53-target gene 3 protein-like 98.89(n)
    99.17(a)
      745451  XM_001149978.2  XP_001149978.1 


    ENSEMBL Gene Tree for TP53TG3 (if available)
    TreeFam Gene Tree for TP53TG3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TP53TG3 gene
    TP53TG3B1 2  TP53TG3C1 2  TP53TG3D2  
    3 SIMAP similar genes for TP53TG3 using alignment to 2 protein entries:     T53G3_HUMAN (see all proteins):
    TP53TG3D    TP53TG3B    TP53TG3C

    TP53TG3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TP53TG3
    PGOHUM00000262296


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in TP53TG3 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2005108181,2
    --32687095(+) CACCGA/GCCCTT 3 G syn1 int10--------

    HapMap Linkage Disequilibrium report for TP53TG3 (32684849 - 32688053 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/73 variations for TP53TG3 (see all 73):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv373e201CNV Deletion23290073
    dgv491e199CNV Deletion23128226
    esv2714223CNV Deletion23290073
    esv2714201CNV Deletion23290073
    esv2714208CNV Deletion23290073
    nsv471500CNV Duplication19718026
    nsv471390CNV Duplication19718026
    nsv436841CNV Insertion17901297
    dgv2825n71CNV Loss21882294
    dgv2708n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TP53TG3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TP53TG3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a novel TP53-inducible gene, TP53TG3. (PubMed id 10534768)1, 2, 3, 9 Ng C.C.... Nakamura Y. (1999)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 24150 HGNC: 30759 AceView: LOC441758 Ensembl:ENSG00000183632 euGenes: HUgn24150
    ECgene: TP53TG3 H-InvDB: TP53TG3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TP53TG3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TP53TG3 gene:
    Search GeneIP for patents involving TP53TG3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     See all of Abcam's Antibodies, Kits and Proteins for TP53TG3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TP53TG3
     Antibodies for TP53TG3
     ELISAs for TP53TG3
     CLIAs for TP53TG3
     Search LifeMap BioReagents cell lines for TP53TG3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53TG3
     SwitchGear 3'UTR luciferase reporter plasmids for TP53TG3
     SwitchGear Promoter luciferase reporter plasmids for TP53TG3
     ThermoFisher Antibody for TP53TG3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53TG3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TP53TG3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TP53TG3
    Customized:
     lentivirus for stable overexpression of TP53TG3
     lentivirus expression plasmids for stable overexpression of TP53TG3
     adenovirus for overexpression of TP53TG3
     Search LSBio for Antibodies for TP53TG3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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