TP53TG3 Gene
protein-coding GIFtS: 38
GCID: GC16M032684
|
|
TP53 target 3
| |
Aliases
for TP53TG3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 8
| Aliases |
|---|
| TP53 Target 31 2 | | TP53TG3A1 2 3 | | P53TG31 2 | | TP53-Inducible Gene 3 Protein2 3 | | P53 Target Gene 32 | | TP53-Target Gene 3 Protein2 |
| External Ids: | HGNC: 307591 | Entrez Gene: 241502 | Ensembl: ENSG000001836327 | UniProtKB: Q9ULZ03 | | ORGUL members: | |
|---|
| NONCODE:n375099 n375359 n377759 n377687 n375023 | see all 6 |
Export aliases for TP53TG3 gene to outside databasesPrevious GC identifers: GC16P032118 GC16P033256 GC16M032682 GC16M032721 GC16P032172 GC16M032590
|---|
Summaries
for TP53TG3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: T53G3_HUMAN, Q9ULZ0Function: May play a significant role in p53/TP53-mediating signaling pathway
|
Genomic Views
for TP53TG3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TP53TG3 gene promoter:
HFH-3 AML1a NF-YA GATA-2 GATA-1 FOXI1 NF-YB CBF-B CP1A NF-Y
Other transcription factors
Search SABiosciences Chromatin IP Primers for TP53TG3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP53TG3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p13TP53TG3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M032684: view genomic region
(about GC identifiers)
Start:
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32,684,849 bp from pter |
End:
|
32,688,053 bp from pter |
Size:
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3,205 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr16+ 32,264,040-32,267,240 |
ORGUL member locations:
Legend (see complete legend)
- n377759
- n377733
- n375023
- n377687
- n375359
- n375099
32264039 32265640 32267240 chr16
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Proteins
for TP53TG3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: T53G3_HUMAN, Q9ULZ0 (See
protein sequence)Recommended Name: TP53-target gene 3 protein Size: 132 amino acids; 13627 Da
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: B2R5K6 Q4KN31 Q9ULY9Alternative splicing: 3 isoforms: Q9ULZ0-1 Q9ULZ0-2 Q9ULZ0-3 Explore the universe of human proteins at neXtProt for TP53TG3: NX_Q9ULZ0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9ULZ0
TP53TG3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001254742.1 NP_057296.1
ENSEMBL proteins: ENSP00000455448 ENSP00000381672 ENSP00000459299 ENSP00000457452 ENSP00000381670
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TP53TG3 for ontologies About GeneDecksing
TP53TG3 Antibody Products:
Assay Products for TP53TG3: |
Protein
Domains /
Families
for TP53TG3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9ULZ0 |
Function
for TP53TG3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: T53G3_HUMAN, Q9ULZ0Function: May play a significant role in p53/TP53-mediating signaling pathwayInduction: By p53/TP53
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TP53TG3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP53TG3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53TG3 |
1 GenomeRNAi human phenotype for TP53TG3:
|
Pathways & Interactions
for TP53TG3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TP53TG3
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TP53TG3 (ENSP000003816724) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TP53TG3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TP53TG3
Search CenterWatch for drugs/clinical trials and news about TP53TG3 / T53G3
|
Transcripts
for TP53TG3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TP53TG3 gene (3 alternative transcripts): NM_015369.1 NM_001267813.1 NM_016212.3 9 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000565622(uc021thb.1) ENST00000398682(uc002edd.3 uc002ede.3)
ENST00000563102 ENST00000569420 ENST00000563658 ENST00000568854 ENST00000562021
ENST00000564154 ENST00000398680
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TP53TG3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP53TG3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TP53TG3 (NM_016212) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TP53TG3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53TG3 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TP53TG3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TP53TG3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TP53TG3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP53TG3 |
24/28 AceView cDNA sequences (see all 28): CA425760 BM554064 AL133588 AW594172 CA417872 BV188965 AA993103 BX381390 BG721667 AA557322 BX370038 NM_015369 BV188304 AI214898 AB023508 AI208123 BX370039 BV179688 N76182 BI459395 BI560253 N64770 BI825431 BF978149
GeneLoc Exon Structure
|
Expression
for TP53TG3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TP53TG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TP53TG3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TP53TG3
UniProtKB/Swiss-Prot: T53G3_HUMAN, Q9ULZ0Tissue specificity: Strongly expressed in testis. Weakly expressed in heart, placenta and skeletal muscle
SABiosciences Custom PCR Arrays for TP53TG3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TP53TG3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TP53TG3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TP53TG3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP53TG3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53TG3 |
Orthologs
for TP53TG3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for TP53TG3 (if available)
TreeFam Gene Tree for TP53TG3 (if available) |
Paralogs
for TP53TG3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TP53TG3 gene
- TP53TG3B1 2 TP53TG3C1 2 TP53TG3D2
3 SIMAP similar genes for TP53TG3 using alignment to 3 protein entries: T53G3_HUMAN (see all proteins):TP53TG3B TP53TG3C TP53TG3D
TP53TG3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TP53TG3
PGOHUM00000262296
|
Genomic Variants
for TP53TG3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TP53TG3 (32684849 - 32688053 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 34 variations for TP53TG3
15/32 CNVs (see all 32): 32119 77293 102251 3117 72538 38978 72558 0794 0195 37632 35388 77304 77295 2214 4440
2 Inversions: 37180 37179 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TP53TG3 |
|
Disorders
/ Diseases
for TP53TG3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TP53TG3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TP53TG3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TP53TG3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and characterization of a novel TP53-inducible gene, TP53TG3. (PubMed id 10534768)1, 2, 3, 9 Ng C.C.... Nakamura Y. (1999)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TP53TG3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TP53TG3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TP53TG3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TP53TG3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TP53TG3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TP53TG3 gene:
Search GeneIP for patents involving TP53TG3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TP53TG3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TP53TG3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TP53TG3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TP53TG3 | | | OriGene Protein Over-expression Lysate for TP53TG3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TP53TG3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP53TG3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TP53TG3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TP53TG3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 |  |  |  | |
| | | | Search Tocris compounds for TP53TG3 |
| |  |  |  |  | | | | |
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 | | | TP53TG3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53TG3 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53TG3 |
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