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TP53TG3 Gene

protein-coding   GIFtS: 35
GCID: GC16M032684

TP53 Target 3

  Search for TP53TG3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TP53 Target 31 2
P53 Target Gene 31 2
TP53TG3A2 3
TP53-Inducible Gene 3 Protein2 3
P53TG32
TP53-Target Gene 3 Protein2

External Ids:    HGNC: 307591   Entrez Gene: 241502   Ensembl: ENSG000001836327   UniProtKB: Q9ULZ03   

Export aliases for TP53TG3 gene to outside databases

Previous GC identifers: GC16P032118 GC16P033256 GC16M032682 GC16M032721 GC16P032172 GC16M032590


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TP53TG3 Gene:
TP53TG3 (TP53 target 3) is a protein-coding gene. An important paralog of this gene is TP53TG3B.

UniProtKB/Swiss-Prot: T53G3_HUMAN, Q9ULZ0
Function: May play a significant role in p53/TP53-mediating signaling pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TP53TG3 gene promoter:
         HFH-3   AML1a   NF-YA   GATA-2   GATA-1   FOXI1   NF-YB   CBF-B   CP1A   NF-Y   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTP53TG3 promoter sequence
   Search Chromatin IP Primers for TP53TG3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TP53TG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p13

TP53TG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP53TG3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M032684:  view genomic region     (about GC identifiers)

Start:
32,684,849 bp from pter      End:
32,688,053 bp from pter
Size:
3,205 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: T53G3_HUMAN, Q9ULZ0 (See protein sequence)
Recommended Name: TP53-target gene 3 protein  
Size: 132 amino acids; 13627 Da
Secondary accessions: B2R5K6 Q4KN31 Q9ULY9
Alternative splicing: 3 isoforms:  Q9ULZ0-1   Q9ULZ0-2   Q9ULZ0-3   

Explore the universe of human proteins at neXtProt for TP53TG3: NX_Q9ULZ0

Explore proteomics data for TP53TG3 at MOPED


See TP53TG3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001254742.1  NP_057296.1  

ENSEMBL proteins: 
 ENSP00000455448   ENSP00000381672   ENSP00000459299   ENSP00000457452   ENSP00000381670  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q9ULZ0


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: T53G3_HUMAN, Q9ULZ0
Function: May play a significant role in p53/TP53-mediating signaling pathway
Induction: By p53/TP53

Phenotypes:
     1 GenomeRNAi human phenotype for TP53TG3:

 Increased S DNA content 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
T53G3_HUMAN, Q9ULZ0: Cytoplasm. Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
extracellular2
mitochondrion2
cytosol1
peroxisome1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus ----
GO:0005737cytoplasm ----

Find genes that share ontologies with TP53TG3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TP53TG3
Interactions:

    Search GeneGlobe Interaction Network for TP53TG3

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for TP53TG3 (ENSP000003816724) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ELAVL1ENSP000003852694STRING: ENSP00000385269
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
Selected ApexBio Compounds for TP53TG3 (see all 15)     About this table
CompoundAction CAS #
AMG232potent and selective piperidinone inhibitor of the MDM2-p53 interaction--
CP 31398 dihydrochloridep53 stabilizing agent. [1217195-61-3]
JNJ-26854165 (Serdemetan)p53 activator, blocking Mdm2-p53 interaction[881202-45-5]
Nutlin-3inhibitor of the MDM2/p53 interaction[890090-75-2]
Nutlin-3a chiralinhibits the MDM2-p53 interaction and activates p53. [675576-98-4]
p53 and MDM2 proteins-interaction-inhibitor chiralinhibitor of the interaction between p53 and MDM2 proteins[939981-37-0]
Pifithrin-miuInhibits p53 binding to mitochondria[64984-31-2]
PRIMA-1Cell-permeable BAX inhibitor, restore p53 activity[5608-24-2]
PRIMA-1METCell-permeable BAX inhibitor, restore p53 activity[5291-32-7]
RG7112Restoration of p53 activity by inhibiting the p53-MDM2 interaction[939981-39-2]

Browse Tocris compounds for TP53TG3 (T53G3)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TP53TG3 gene (3 alternative transcripts): 
NM_001267813.1  NM_015369.1  NM_016212.4  

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000565622(uc021thb.1) ENST00000398682(uc002edd.3 uc002ede.3)
ENST00000563102 ENST00000569420 ENST00000563658 ENST00000568854 ENST00000562021
ENST00000564154 ENST00000398680
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Selected AceView cDNA sequences (see all 28):

CA417872 BM554064 AL133588 CA425760 AW594172 AA993103 BV188304 BV179688 
AI208123 BX381390 NM_015369 BG721667 AA557322 BX370039 AB023508 AI214898 
BX370038 BV188965 BI825431 BI459395 N76182 N64770 BI560253 BF978149 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TP53TG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TP53TG3 Expression
About this image

TP53TG3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TP53TG3 Protein Expression

UniProtKB/Swiss-Prot: T53G3_HUMAN, Q9ULZ0
Tissue specificity: Strongly expressed in testis. Weakly expressed in heart, placenta and skeletal muscle

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53TG3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for TP53TG3 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia LOC7498151 TP53-target gene 3 protein-like 97.55(n)
98.17(a)
  749815  XM_003318082.1  XP_003318130.1 


ENSEMBL Gene Tree for TP53TG3 (if available)
TreeFam Gene Tree for TP53TG3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TP53TG3 gene
TP53TG3B1 2  TP53TG3C1 2  TP53TG3D1 2  LOC102723713  
3 SIMAP similar genes for TP53TG3 using alignment to 2 protein entries:     T53G3_HUMAN (see all proteins):
TP53TG3D    TP53TG3B    TP53TG3C

Find genes that share paralogs with TP53TG3           About GenesLikeMe


1 Pseudogenes.org Pseudogene for TP53TG3
PGOHUM00000262296


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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1 SNPs for TP53TG3    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2005108181,2
--32687095(+) CACCGA/GCCCTT 3 G syn1 int10--------

HapMap Linkage Disequilibrium report for TP53TG3 (32684849 - 32688053 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for TP53TG3 (see all 73):    About this table    
Variant IDTypeSubtypePubMed ID
dgv373e201CNV Deletion23290073
dgv491e199CNV Deletion23128226
esv2714223CNV Deletion23290073
esv2714201CNV Deletion23290073
esv2714208CNV Deletion23290073
nsv471500CNV Duplication19718026
nsv471390CNV Duplication19718026
nsv436841CNV Insertion17901297
dgv2825n71CNV Loss21882294
dgv2708n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TP53TG3 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TP53TG3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Isolation and characterization of a novel TP53-inducible gene, TP53TG3. (PubMed id 10534768)1, 2, 3, 9 Ng C.C.... Nakamura Y. (Genes Chromosomes Cancer 1999)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
  4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 24150 HGNC: 30759 AceView: LOC441758 Ensembl:ENSG00000183632 euGenes: HUgn24150
ECgene: TP53TG3 H-InvDB: TP53TG3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TP53TG3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TP53TG3 gene:
Search GeneIP for patents involving TP53TG3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53TG3
 SwitchGear 3'UTR luciferase reporter plasmids for TP53TG3
 SwitchGear Promoter luciferase reporter plasmids for TP53TG3
 ThermoFisher Antibody for TP53TG3
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53TG3
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TP53TG3
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TP53TG3
 Search LSBio for Antibodies for TP53TG3
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 ApexBio compounds for TP53TG3
 Search Addgene for plasmids for TP53TG3
  Search eBioscience for proteins for TP53TG3
  Search eBioscience for elisas for TP53TG3
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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