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Aliases for TP53TG1 Gene

Subcategory (RNA class) for TP53TG1 Gene

lncRNA

Quality Score for this RNA gene is

3

Aliases for TP53TG1 Gene

  • TP53 Target 1 (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 96 2 3
  • TP53 Activated Protein 1 2 3
  • TP53 Target Gene 1 2 3
  • TP53AP1 3 4
  • P53TG1 3 4
  • Tumor Protein P53-Activated Protein 1 4
  • TP53-Inducible Gene 1 Protein 4
  • H_RG012D21.9 3
  • NCRNA00096 3
  • LINC00096 3
  • P53TG1-D 3

External Ids for TP53TG1 Gene

Previous HGNC Symbols for TP53TG1 Gene

  • TP53AP1

Previous GeneCards Identifiers for TP53TG1 Gene

  • GC07M085489
  • GC07U902535
  • GC07M086792
  • GC07M086954
  • GC07M081565

Summaries for TP53TG1 Gene

GeneCards Summary for TP53TG1 Gene

TP53TG1 (TP53 Target 1 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the lncRNA class.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP53TG1 Gene

Genomics for TP53TG1 Gene

Regulatory Elements for TP53TG1 Gene

Genomic Location for TP53TG1 Gene

Start:
87,325,225 bp from pter
End:
87,345,515 bp from pter
Size:
20,291 bases
Orientation:
Minus strand

Genomic View for TP53TG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TP53TG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53TG1 Gene

Proteins for TP53TG1 Gene

  • Protein details for TP53TG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2A0-T53G1_HUMAN
    Recommended name:
    TP53-target gene 1 protein
    Protein Accession:
    Q9Y2A0
    Secondary Accessions:
    • D6W5P2
    • Q52MB0
    • Q9Y2A1
    • Q9Y2A2
    • Q9Y2A3

    Protein attributes for TP53TG1 Gene

    Size:
    90 amino acids
    Molecular mass:
    10275 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TP53TG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TP53TG1 Gene

Proteomics data for TP53TG1 Gene at MOPED

Post-translational modifications for TP53TG1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TP53TG1 Gene

Domains for TP53TG1 Gene

Protein Domains for TP53TG1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TP53TG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TP53TG1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TP53TG1 Gene

Function for TP53TG1 Gene

Molecular function for TP53TG1 Gene

UniProtKB/Swiss-Prot Induction: Up-regulated by UV irradiation and exposure to bleomycin or cisplatin in a p53/TP53-dependent manner.

Gene Ontology (GO) - Molecular Function for TP53TG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TP53TG1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TP53TG1 Gene

Localization for TP53TG1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TP53TG1 Gene

Pathways for TP53TG1 Gene

SuperPathways for TP53TG1 Gene

No Data Available

Interacting Proteins for TP53TG1 Gene

Selected Interacting proteins: Q9Y2A0-T53G1_HUMAN for TP53TG1 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for TP53TG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress TAS 9713990
GO:0006974 cellular response to DNA damage stimulus NAS 9713990
genes like me logo Genes that share ontologies with TP53TG1: view

No data available for Pathways by source for TP53TG1 Gene

Compounds for TP53TG1 Gene

(15) ApexBio Compounds for TP53TG1 Gene

Compound Action Cas Number
AMG232 potent and selective piperidinone inhibitor of the MDM2-p53 interaction.
CP 31398 dihydrochloride p53 stabilizing agent. [1217195-61-3]
JNJ-26854165 (Serdemetan) p53 activator, blocking Mdm2-p53 interaction [881202-45-5]
Nutlin-3 inhibitor of the MDM2/p53 interaction [890090-75-2]
Nutlin-3a chiral inhibits the MDM2-p53 interaction and activates p53. [675576-98-4]
p53 and MDM2 proteins-interaction-inhibitor chiral inhibitor of the interaction between p53 and MDM2 proteins. [939981-37-0]
Pifithrin-miu Inhibits p53 binding to mitochondria. [64984-31-2]
PRIMA-1 Cell-permeable BAX inhibitor, restore p53 activity [5608-24-2]
PRIMA-1MET Cell-permeable BAX inhibitor, restore p53 activity [5291-32-7]
RG7112 Restoration of p53 activity by inhibiting the p53-MDM2 interaction. [939981-39-2]
RG7388 Blocking the MDM2-p53 interaction stabilizes p53. [1229705-06-9]
RITA (NSC 652287) Cell-permeable antitumor agent, blocking Mdm2-p53 interaction and p53 ubiquitination [213261-59-7]
SJ 172550 Inhibits the MDMX-p53 interaction in cultured retinoblastoma cells. [431979-47-4]
Tenovin-1 Cell-permeable, reversible SIRT2 inhibitor, activates p53 [380315-80-0]
Tenovin-3 Tenovin-3 [1011301-27-1]
genes like me logo Genes that share compounds with TP53TG1: view

Transcripts for TP53TG1 Gene

Unigene Clusters for TP53TG1 Gene

TP53 target 1 (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TP53TG1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2
SP1: -
SP2:
SP3: - -
SP4: -

Relevant External Links for TP53TG1 Gene

GeneLoc Exon Structure for
TP53TG1
ECgene alternative splicing isoforms for
TP53TG1

Expression for TP53TG1 Gene

mRNA expression in normal human tissues for TP53TG1 Gene

SOURCE GeneReport for Unigene cluster for TP53TG1 Gene Hs.274329

mRNA Expression by UniProt/SwissProt for TP53TG1 Gene

Q9Y2A0-T53G1_HUMAN
Tissue specificity: Isoform 1, isoform 2, isoform 3 and isoform 4 are ubiquitously expressed.
genes like me logo Genes that share expressions with TP53TG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for TP53TG1 Gene

Orthologs for TP53TG1 Gene

Evolution for TP53TG1 Gene

ENSEMBL:
Gene Tree for TP53TG1 (if available)
TreeFam:
Gene Tree for TP53TG1 (if available)

No data available for Orthologs for TP53TG1 Gene

Paralogs for TP53TG1 Gene

No data available for Paralogs for TP53TG1 Gene

Variants for TP53TG1 Gene

Sequence variations from dbSNP and Humsavar for TP53TG1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs802031 -- 87,332,046(+) gtctc(C/T)gacgt intron-variant
rs802032 -- 87,333,934(+) tagga(A/G)tggaa intron-variant
rs802033 -- 87,334,896(+) atgta(C/T)gatat intron-variant
rs802034 -- 87,336,726(+) TTATA(A/G)TAACT intron-variant
rs802035 -- 87,340,243(+) CTCAT(C/T)TGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TP53TG1 Gene

Variant ID Type Subtype PubMed ID
nsv888677 CNV Gain 21882294
nsv464622 CNV Gain 19166990
nsv428177 CNV Loss 18775914
nsv888678 CNV Loss 21882294
esv272256 CNV Insertion 20981092
esv269158 CNV Insertion 20981092

Relevant External Links for TP53TG1 Gene

HapMap Linkage Disequilibrium report
TP53TG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TP53TG1 Gene

Disorders for TP53TG1 Gene

Relevant External Links for TP53TG1

Genetic Association Database (GAD)
TP53TG1
genes like me logo Genes that share disorders with TP53TG1: view

No data available for UniProtKB/Swiss-Prot for TP53TG1 Gene

Publications for TP53TG1 Gene

  1. Isolation of a novel TP53 target gene from a colon cancer cell line carrying a highly regulated wild-type TP53 expression system. (PMID: 9713990) Takei Y. … Nakamura Y. (Genes Chromosomes Cancer 1998) 2 3 4
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 48
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4

Products for TP53TG1 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate TP53TG1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TP53TG1
    • Block miRNA regulation of TP53TG1 using miScript Target Protectors

    Sources for TP53TG1 Gene

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