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TP53TG1 Gene

RNA gene   GIFtS: 33
GCID: GC07M086954

TP53 Target 1 (Non-Protein Coding)

(Previous name: TP53 activated protein 1)
(Previous symbol: TP53AP1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 3

Aliases
TP53 Target 1 (Non-Protein Coding)1 2     LINC000962
TP53AP11 2 3     NCRNA000962
P53TG12 3     P53TG1-D2
Long Intergenic Non-Protein Coding RNA 961     TP53-Inducible Gene 1 Protein3
TP53 Activated Protein 11     Tumor Protein P53-Activated Protein 13
TP53 Target Gene 11     

External Ids:    HGNC: 170261   Entrez Gene: 112572   Ensembl: ENSG000001821657   UniProtKB: Q9Y2A03   
ORGUL members:         

Export aliases for TP53TG1 gene to outside databases

Previous GC identifers: GC07M085489 GC07U902535 GC07M086792 GC07M081565


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TP53TG1 Gene:
TP53TG1 (TP53 target 1 (non-protein coding)) is an RNA gene, and is affiliated with the lncRNA class.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TP53TG1 gene promoter:
         Oct-B1   HFH-3   oct-B2   oct-B3   POU2F2   POU2F2C   FOXI1   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTP53TG1 promoter sequence
   Search Chromatin IP Primers for TP53TG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TP53TG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.1   Ensembl cytogenetic band:  7q21.12   HGNC cytogenetic band: 7q21.1

TP53TG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP53TG1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M086954:  view genomic region     (about GC identifiers)

Start:
86,954,541 bp from pter      End:
86,974,831 bp from pter
Size:
20,291 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 86,286,157-86,306,312     
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TP53TG1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: T53G1_HUMAN, Q9Y2A0 (See protein sequence)
Recommended Name: TP53-target gene 1 protein  
Size: 90 amino acids; 10275 Da
Secondary accessions: D6W5P2 Q52MB0 Q9Y2A1 Q9Y2A2 Q9Y2A3
Alternative splicing: 4 isoforms:  Q9Y2A0-1   Q9Y2A0-2   Q9Y2A0-3   Q9Y2A0-4   

Explore the universe of human proteins at neXtProt for TP53TG1: NX_Q9Y2A0


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
LNCRNA: Long non-coding RNAs

ProtoNet protein and cluster: Q9Y2A0


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: T53G1_HUMAN, Q9Y2A0
Induction: Up-regulated by UV irradiation and exposure to bleomycin or cisplatin in a p53/TP53-dependent manner

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
     
Find genes that share ontologies with TP53TG1           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

    Search GeneGlobe Interaction Network for TP53TG1

3 Interacting proteins for TP53TG1 (Q9Y2A02, 3) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SAT1P216732, 3MINT-63590 I2D: score=3 
PTPLAD1Q9P0353I2D: score=1 
TP53P046373I2D: score=1 
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006950response to stress TAS9713990
GO:0006974cellular response to DNA damage stimulus NAS9713990

Find genes that share ontologies with TP53TG1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
Selected ApexBio Compounds for TP53TG1 (see all 15)     About this table
CompoundAction CAS #
AMG232potent and selective piperidinone inhibitor of the MDM2-p53 interaction--
CP 31398 dihydrochloridep53 stabilizing agent. [1217195-61-3]
JNJ-26854165 (Serdemetan)p53 activator, blocking Mdm2-p53 interaction[881202-45-5]
Nutlin-3inhibitor of the MDM2/p53 interaction[890090-75-2]
Nutlin-3a chiralinhibits the MDM2-p53 interaction and activates p53. [675576-98-4]
p53 and MDM2 proteins-interaction-inhibitor chiralinhibitor of the interaction between p53 and MDM2 proteins[939981-37-0]
Pifithrin-miuInhibits p53 binding to mitochondria[64984-31-2]
PRIMA-1Cell-permeable BAX inhibitor, restore p53 activity[5608-24-2]
PRIMA-1METCell-permeable BAX inhibitor, restore p53 activity[5291-32-7]
RG7112Restoration of p53 activity by inhibiting the p53-MDM2 interaction[939981-39-2]

Browse Tocris compounds for TP53TG1 (T53G1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TP53TG1 gene: 
NM_007233.1  

Unigene Cluster for TP53TG1:

TP53 target 1 (non-protein coding)
Hs.274329  [show with all ESTs]
Unigene Representative Sequence: BC068535
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000359941(lincRNA)(uc003uir.4) ENST00000416560(lincRNA)(uc003uip.4 uc003uiq.4)
ENST00000610086(lincRNA) ENST00000432193(lincRNA) ENST00000421293(lincRNA) ENST00000542586(lincRNA)
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Additional mRNA sequence: 

AK292782.1 BC002709.2 BC068535.1 BC103631.1 BT009845.1 CR542141.1 NR_015381.1 

5 DOTS entries:

DT.100724985  DT.95370964  DT.453004  DT.100773860  DT.100773861 

Selected AceView cDNA sequences (see all 104):

AA283095 CR601454 BM915584 AB007455 AB007457 AA127964 AI742848 BM850328 
AA447725 BX110032 AB007456 BM550333 BM726466 AA873320 AA970396 AB007458 
BC002709 BM912218 BE858272 BQ961841 BM912196 BQ581775 AI129548 CR542141 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TP53TG1    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2
SP1:                    -               
SP2:                                    
SP3:                    -     -         
SP4:                          -         


ECgene alternative splicing isoforms for TP53TG1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for TP53TG1:none

TP53TG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATGCTGGGGA
TP53TG1 Expression
About this image

TP53TG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.274329

UniProtKB/Swiss-Prot: T53G1_HUMAN, Q9Y2A0
Tissue specificity: Isoform 1, isoform 2, isoform 3 and isoform 4 are ubiquitously expressed

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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ENSEMBL Gene Tree for TP53TG1 (if available)
TreeFam Gene Tree for TP53TG1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TP53TG1 (see all 376)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs10894701,2
C,F,H--86954222(+) caagaC/Tgattt 1 -- int119Minor allele frequency- T:0.06NS EA NA CSA WA 2250
rs1895341701,2
--86954408(+) AAAATA/GTAACC 1 -- int10--------
rs1451269031,2
C--86954438(+) TTTGGA/CCAATC 1 -- int10--------
rs1818385441,2
--86954459(+) AAACAC/TGTTAA 1 -- int10--------
rs1430519751,2
--86954848(+) CTTACA/GTTGGT 1 -- int10--------
rs1868995971,2
--86955097(+) GGTGGA/GGTTAA 1 -- int10--------
rs1901899941,2
--86955107(+) ATCTTC/GTATGT 1 -- int10--------
rs1125606871,2
C,F--86955237(+) AATTAT/CTTTTA 1 -- int12Minor allele frequency- C:0.04NA 122
rs1386513491,2
--86955389(+) CAATAA/CATATA 1 -- int10--------
rs746480031,2
C,F--86955500(+) AGCAGG/CGCTAG 1 -- int11Minor allele frequency- C:0.03WA 118

HapMap Linkage Disequilibrium report for TP53TG1 (86954541 - 86974831 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for TP53TG1:    About this table    
Variant IDTypeSubtypePubMed ID
esv269158CNV Insertion20981092
esv272256CNV Insertion20981092
nsv888678CNV Loss21882294
nsv428177CNV Loss18775914
nsv464622CNV Gain19166990
nsv888677CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with TP53TG1           About GenesLikeMe

Genetic Association Database (GAD): TP53TG1

Export disorders for TP53TG1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TP53TG1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TP53TG1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Isolation of a novel TP53 target gene from a colon cancer cell line carrying a highly regulated wild-type TP53 expression system. (PubMed id 9713990)1, 2, 3 Takei Y.... Nakamura Y. (Genes Chromosomes Cancer 1998)
  2. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  4. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  7. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 11257 HGNC: 17026 AceView: TP53AP1 Ensembl:ENSG00000182165 euGenes: HUgn11257
ECgene: TP53TG1 H-InvDB: TP53TG1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TP53TG1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TP53TG1 gene:
Search GeneIP for patents involving TP53TG1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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