Aliases for TP53RK Gene
External Ids for TP53RK Gene
Previous Symbols for TP53RK Gene
GeneCards Summary for TP53RK Gene
TP53RK (TP53 Regulating Kinase) is a Protein Coding gene. Diseases associated with TP53RK include shipyard eye. GO annotations related to this gene include protein serine/threonine kinase activity and p53 binding.
UniProtKB/Swiss-Prot for TP53RK Gene
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates Ser-15 of p53/TP53 protein and may therefore participate in its activation.