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TP53RK Gene

protein-coding   GIFtS: 60
GCID: GC20M045313

TP53 Regulating Kinase

(Previous name: chromosome 20 open reading frame 64)
(Previous symbol: C20orf64)
  See TP53RK-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TP53 Regulating Kinase1 2     EC 2.7.11.13 8
C20orf641 2 3     Chromosome 20 Open Reading Frame 641
Atypical Serine/Threonine Protein Kinase TP53RK2 3     BUD322
Nori-22 3     Nori-2p2
PRPK2 3     dJ101A22
EKC/KEOPS Complex Subunit TP53RK2 3     TP53-Regulating Kinase2
P53-Related Protein Kinase2 3     EC 3.6.-.-3

External Ids:    HGNC: 161971   Entrez Gene: 1128582   Ensembl: ENSG000001723157   OMIM: 6086795   UniProtKB: Q96S443   

Export aliases for TP53RK gene to outside databases

Previous GC identifers: GC20M045998 GC20M044746 GC20M042054


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TP53RK Gene:
TP53RK (TP53 regulating kinase) is a protein-coding gene. Diseases associated with TP53RK include shipyard eye. GO annotations related to this gene include protein serine/threonine kinase activity and p53 binding.

UniProtKB/Swiss-Prot: PRPK_HUMAN, Q96S44
Function: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on
adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably
involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of
A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the
catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein
and may therefore participate in its activation

Gene Wiki entry for TP53RK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the TP53RK gene promoter:
         GR   AML1a   GR-beta   FOXD3   E47   POU2F1   POU2F1a   FOXO4   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTP53RK promoter sequence
   Search Chromatin IP Primers for TP53RK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TP53RK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.2   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.2

TP53RK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP53RK gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M045313:  view genomic region     (about GC identifiers)

Start:
45,313,004 bp from pter      End:
45,318,418 bp from pter
Size:
5,415 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PRPK_HUMAN, Q96S44 (See protein sequence)
Recommended Name: TP53-regulating kinase  
Size: 253 amino acids; 28160 Da
Subunit: Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex
dimerizes. Interacts with TPRKB
Miscellaneous: This protein is considered an atypical serine/threonine kinase, because it lacks the conventional
structural elements necessary for the substrate recognition as well as a lysine residue that in all other
serine/threonine kinases participates in the catalytic event
Secondary accessions: B3KU44 Q3T977 Q5JZ01 Q6NZ60 Q96FM7 Q9NQE6

Explore the universe of human proteins at neXtProt for TP53RK: NX_Q96S44

Explore proteomics data for TP53RK at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys40
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for TP53RK (Q96S44)
     VRLRGRK  RGRKRSM  VDLYVLE 


    See TP53RK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_291028.3  
    ENSEMBL proteins: 
     ENSP00000361186   ENSP00000361174  

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    antibodies-online proteins for TP53RK (6 products) 

     
    antibodies-online peptides for TP53RK

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: TP53 regulating kinase
    Bud32 family

    5 InterPro protein domains:
     IPR022495 Bud32
     IPR011009 Kinase-like_dom
     IPR010440 LipoPS_kinase
     IPR000719 Prot_kinase_dom
     IPR008266 Tyr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q96S44

    ProtoNet protein and cluster: Q96S44

    UniProtKB/Swiss-Prot: PRPK_HUMAN, Q96S44
    Similarity: Belongs to the protein kinase superfamily. BUD32 family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with TP53RK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRPK_HUMAN, Q96S44
    Function: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on
    adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably
    involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of
    A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the
    catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein
    and may therefore participate in its activation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 3.6.-.-1

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IDA11546806
    GO:0003824catalytic activity ----
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA11546806
    GO:0004713protein tyrosine kinase activity IEA--
         
    Find genes that share ontologies with TP53RK           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TP53RK:
     Decreased focal adhesion (FA)  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TP53RK

    miRNA
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    miRTarBase miRNAs that target TP53RK:
    hsa-mir-505-5p (MIRT037962), hsa-mir-196a-5p (MIRT048227)

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    6 qRT-PCR Assays for microRNAs that regulate TP53RK:
    hsa-miR-30c-2* hsa-miR-3671 hsa-miR-513b hsa-miR-607 hsa-miR-30c-1* hsa-miR-3202
    SwitchGear 3'UTR luciferase reporter plasmidTP53RK 3' UTR sequence
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    Addgene plasmids for TP53RK 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRPK_HUMAN, Q96S44: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11546806
    GO:0016020membrane IEA--

    Find genes that share ontologies with TP53RK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TP53RK
    Interactions:

        GeneGlobe Interaction Network for TP53RK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TP53RK (Q96S441, 3 ENSP000003611864) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TPRKBQ9Y3C41, 3, ENSP000002724244EBI-739588,EBI-750123 I2D: score=3 STRING: ENSP00000272424
    OSGEPQ9NPF43, ENSP000002065424I2D: score=6 STRING: ENSP00000206542
    PSMC2P359983, ENSP000002926444I2D: score=4 STRING: ENSP00000292644
    TP53P046373, ENSP000002693054I2D: score=2 STRING: ENSP00000269305
    H2AFZP0C0S53, ENSP000002964174I2D: score=1 STRING: ENSP00000296417
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA11546806
    GO:0008033tRNA processing IEA--
    GO:0009103lipopolysaccharide biosynthetic process IEA--

    Find genes that share ontologies with TP53RK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TP53RK (PRPK)

    2 HMDB Compounds for TP53RK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TP53RK gene: 
    NM_033550.3  

    Unigene Cluster for TP53RK:

    TP53 regulating kinase
    Hs.440263  [show with all ESTs]
    Unigene Representative Sequence: NM_033550
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372114(uc002xsj.3 uc002xsk.3) ENST00000372102
    miRNA
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    hsa-miR-30c-2* hsa-miR-3671 hsa-miR-513b hsa-miR-607 hsa-miR-30c-1* hsa-miR-3202
    SwitchGear 3'UTR luciferase reporter plasmidTP53RK 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat TP53RK

    Additional mRNA sequence: 

    AB017505.2 AB065434.1 AK096502.1 AK315182.1 BC009727.1 BC010637.1 BC019621.1 BC035461.1 
    BC066309.1 

    8 DOTS entries:

    DT.312275  DT.97818172  DT.95145981  DT.92428013  DT.95164077  DT.97783906  DT.420945  DT.95274223 

    Selected AceView cDNA sequences (see all 348):

    CD672257 AI889233 BI825806 NM_033550 CB163315 BM674579 BM554197 AI510701 
    BI765509 AI264679 AI767571 AI304605 BC035461 BM053094 BM847243 CR606281 
    AI758242 AW614324 BE048937 BX104251 AW138748 Z45620 BC010637 AA767449 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TP53RK    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for TP53RK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TP53RK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAACTGTG
    TP53RK Expression
    About this image


    TP53RK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    TP53RK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TP53RK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.440263

    UniProtKB/Swiss-Prot: PRPK_HUMAN, Q96S44
    Tissue specificity: Highly expressed in testis. Weakly expressed in heart kidney and spleen

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TP53RK gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trp53rk1 , 5 transformation related protein 53 regulating kinase1, 5 84.83(n)1
    87.84(a)1
      2 (87.22 cM)5
    763671  NM_023815.41  NP_076304.21 
     1667925315 
    chicken
    (Gallus gallus)
    Aves TP53RK1 TP53 regulating kinase 72.55(n)
    72.85(a)
      428145  XM_425703.4  XP_425703.3 
    lizard
    (Anolis carolinensis)
    Reptilia TP53RK6
    TP53 regulating kinase
    68(a)
    1 ↔ 1
    4(144672391-144675751)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.172592 Xenopus laevis transcribed sequence with moderate similarity more 75.71(n)    CF522117.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570547802   -- 71.14(n)    57054780 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG106731 CG10673 53.36(n)
    46.79(a)
      38600  NM_139691.2  NP_647948.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F52C12.61 F52C12.6 50.23(n)
    45.54(a)
      13192290  NM_001268308.1  NP_001255237.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BUD32(YGR262C)4
    BUD321
    Protein kinase, component of the EKC/KEOPS complex more4
    BUD321
    44.76(n)1
    40.38(a)1
      7(1017759-1016974)4
    8531781, 4  NP_011778.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G261101 AT5G26110 49.15(n)
    48.84(a)
      832680  NM_122512.3  NP_568482.1 
    rice
    (Oryza sativa)
    Liliopsida Os.392612 Oryza sativa (japonica cultivar-group) putative endopeptidase more 73.3(n)    NM_196549.1 


    ENSEMBL Gene Tree for TP53RK (if available)
    TreeFam Gene Tree for TP53RK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TP53RK (see all 116)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1491215761,2
    --45315127(+) GTTCAA/GTGCCA 1 -- ut310--------
    rs1862065061,2
    --45315217(+) AGAACA/TTGACT 1 -- ut310--------
    rs455443341,2
    C,F--45315346(+) ATTTAC/TTTTGA 1 -- ut315Minor allele frequency- T:0.06WA NA EA EU 1679
    rs769884021,2
    C--45315351(+) CTTTGA/GAAAAA 1 -- ut312Minor allele frequency- G:0.02CSA WA 120
    rs130430561,2
    C,F--45315375(+) TGTGGT/CTGTCA 1 -- ut31 ese34Minor allele frequency- C:0.03NA EU 1330
    rs148721,2
    H--45315490(+) CTTCAG/TAAAGG 2 M L mis1 ese35Minor allele frequency- T:0.00MN NS EA 590
    rs1152707941,2
    C--45315536(+) AGGAAG/CGCCTT 2 /A syn11Minor allele frequency- C:0.01EA 210
    rs2013522711,2
    --45315554(+) ACATAA/GAGGTC 2 L syn10--------
    rs2009215541,2
    --45315610(+) GTCTAC/TGAGCA 2 I V mis10--------
    rs1410878371,2
    C,F--45315635(+) TCCAGG/CGGGGG 2 /P syn11Minor allele frequency- C:0.00NA 4552

    HapMap Linkage Disequilibrium report for TP53RK (45313004 - 45318418 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TP53RK:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912901CNV Loss21882294

    Human Gene Mutation Database (HGMD): TP53RK
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TP53RK
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608679    OMIM disorders: --

    1 disease for TP53RK:    
    About MalaCards
    shipyard eye

    1 disease from the University of Copenhagen DISEASES database for TP53RK:
    Shipyard eye

    Find genes that share disorders with TP53RK           About GenesLikeMe

    Genetic Association Database (GAD): TP53RK
    Human Genome Epidemiology (HuGE) Navigator: TP53RK (2 documents)

    Export disorders for TP53RK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TP53RK gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with TP53RK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes. (PubMed id 11546806)1, 2, 3, 9 Abe Y.... Enomoto Y. (J. Biol. Chem. 2001)
    2. Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency. (PubMed id 12914926)1, 3, 9 Facchin S....Pinna L.A. (FEBS Lett. 2003)
    3. The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME. (PubMed id 22912744)1, 2 Costessi A....Stunnenberg H.G. (PLoS ONE 2012)
    4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Identification of CGI-121, a novel PRPK (p53-related protein kinase)- binding protein. (PubMed id 12659830)1, 2 Miyoshi A.... Ueda N. (Biochem. Biophys. Res. Commun. 2003)
    8. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    9. Phosphorylation and activation of the atypical kinase p53-related protein kinase (PRPK) by Akt/PKB. (PubMed id 17712528)1, 9 Facchin S....Pinna L.A. (Cell. Mol. Life Sci. 2007)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 112858 HGNC: 16197 AceView: SLC13A3andTP53RK Ensembl:ENSG00000172315 euGenes: HUgn112858
    ECgene: TP53RK H-InvDB: TP53RK

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TP53RK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TP53RK gene:
    Search GeneIP for patents involving TP53RK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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