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Aliases for TP53RK Gene

Aliases for TP53RK Gene

  • TP53 Regulating Kinase 2 3 5
  • Atypical Serine/Threonine Protein Kinase TP53RK 3 4
  • EKC/KEOPS Complex Subunit TP53RK 3 4
  • P53-Related Protein Kinase 3 4
  • EC 2.7.11.1 4 63
  • C20orf64 3 4
  • Nori-2 3 4
  • PRPK 3 4
  • Chromosome 20 Open Reading Frame 64 2
  • EC 3.6.-.- 4
  • Nori-2p 3
  • DJ101A2 3
  • BUD32 3

External Ids for TP53RK Gene

Previous HGNC Symbols for TP53RK Gene

  • C20orf64

Previous GeneCards Identifiers for TP53RK Gene

  • GC20M045998
  • GC20M044746
  • GC20M045313
  • GC20M042054

Summaries for TP53RK Gene

GeneCards Summary for TP53RK Gene

TP53RK (TP53 Regulating Kinase) is a Protein Coding gene. Diseases associated with TP53RK include Narcolepsy. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity.

UniProtKB/Swiss-Prot for TP53RK Gene

  • Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates Ser-15 of p53/TP53 protein and may therefore participate in its activation.

Gene Wiki entry for TP53RK Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP53RK Gene

Genomics for TP53RK Gene

Regulatory Elements for TP53RK Gene

Enhancers for TP53RK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TP53RK on UCSC Golden Path with GeneCards custom track

Promoters for TP53RK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TP53RK on UCSC Golden Path with GeneCards custom track

Genomic Location for TP53RK Gene

Chromosome:
20
Start:
46,684,365 bp from pter
End:
46,689,779 bp from pter
Size:
5,415 bases
Orientation:
Minus strand

Genomic View for TP53RK Gene

Genes around TP53RK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TP53RK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TP53RK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53RK Gene

Proteins for TP53RK Gene

  • Protein details for TP53RK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S44-PRPK_HUMAN
    Recommended name:
    TP53-regulating kinase
    Protein Accession:
    Q96S44
    Secondary Accessions:
    • B3KU44
    • Q3T977
    • Q5JZ01
    • Q6NZ60
    • Q96FM7
    • Q9NQE6

    Protein attributes for TP53RK Gene

    Size:
    253 amino acids
    Molecular mass:
    28160 Da
    Quaternary structure:
    • Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes. Interacts with TPRKB.
    Miscellaneous:
    • This protein is considered an atypical serine/threonine kinase, because it lacks the conventional structural elements necessary for the substrate recognition as well as a lysine residue that in all other serine/threonine kinases participates in the catalytic event. TP53RK has protein kinase activity in vitro, but in the context of the EKC/KEOPS complex, the catalytic subunit OSGEP switches the activity of TP53RK from kinase into ATPase (By similarity).

neXtProt entry for TP53RK Gene

Proteomics data for TP53RK Gene at MOPED

Selected DME Specific Peptides for TP53RK Gene

Post-translational modifications for TP53RK Gene

  • Ubiquitination at Lys 40
  • Modification sites at PhosphoSitePlus

Other Protein References for TP53RK Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TP53RK Gene

Gene Families for TP53RK Gene

Protein Domains for TP53RK Gene

Suggested Antigen Peptide Sequences for TP53RK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96S44

UniProtKB/Swiss-Prot:

PRPK_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. BUD32 family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. BUD32 family.
genes like me logo Genes that share domains with TP53RK: view

Function for TP53RK Gene

Molecular function for TP53RK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates Ser-15 of p53/TP53 protein and may therefore participate in its activation.

Enzyme Numbers (IUBMB) for TP53RK Gene

Gene Ontology (GO) - Molecular Function for TP53RK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016773 phosphotransferase activity, alcohol group as acceptor IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TP53RK: view
genes like me logo Genes that share phenotypes with TP53RK: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TP53RK

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TP53RK Gene

Localization for TP53RK Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP53RK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TP53RK Gene COMPARTMENTS Subcellular localization image for TP53RK gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for TP53RK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000408 EKC/KEOPS complex IBA --
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with TP53RK: view

Pathways & Interactions for TP53RK Gene

genes like me logo Genes that share pathways with TP53RK: view

SIGNOR curated interactions for TP53RK Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TP53RK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 11546806
GO:0070525 tRNA threonylcarbamoyladenosine metabolic process IBA --
GO:1901796 regulation of signal transduction by p53 class mediator TAS --
genes like me logo Genes that share ontologies with TP53RK: view

Drugs & Compounds for TP53RK Gene

(1) Drugs for TP53RK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for TP53RK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with TP53RK: view

Transcripts for TP53RK Gene

mRNA/cDNA for TP53RK Gene

Unigene Clusters for TP53RK Gene

TP53 regulating kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TP53RK Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1:
SP2:

Relevant External Links for TP53RK Gene

GeneLoc Exon Structure for
TP53RK
ECgene alternative splicing isoforms for
TP53RK

Expression for TP53RK Gene

mRNA expression in normal human tissues for TP53RK Gene

Protein differential expression in normal tissues from HIPED for TP53RK Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TP53RK Gene



SOURCE GeneReport for Unigene cluster for TP53RK Gene Hs.440263

mRNA Expression by UniProt/SwissProt for TP53RK Gene

Q96S44-PRPK_HUMAN
Tissue specificity: Highly expressed in testis. Weakly expressed in heart kidney and spleen.
genes like me logo Genes that share expression patterns with TP53RK: view

Protein tissue co-expression partners for TP53RK Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TP53RK Gene

Orthologs for TP53RK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TP53RK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TP53RK 35
  • 90.81 (n)
  • 91.56 (a)
TP53RK 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TP53RK 35
  • 92.32 (n)
  • 93.83 (a)
TP53RK 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trp53rk 35
  • 84.83 (n)
  • 87.84 (a)
Trp53rkb 16
2810408M09Rik 36
  • 85 (a)
OneToMany
Trp53rk 36
  • 85 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TP53RK 35
  • 99.47 (n)
  • 99.6 (a)
TP53RK 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tp53rk 35
  • 84.98 (n)
  • 89.19 (a)
oppossum
(Monodelphis domestica)
Mammalia TP53RK 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves TP53RK 35
  • 72.55 (n)
  • 72.85 (a)
TP53RK 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TP53RK 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tp53rk 35
  • 68.17 (n)
  • 72.97 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17259 35
zebrafish
(Danio rerio)
Actinopterygii tp53rk 35
  • 64.97 (n)
  • 68.06 (a)
tp53rk 36
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007476 35
  • 50.31 (n)
  • 44.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10673 35
  • 53.36 (n)
  • 46.79 (a)
CG10673 36
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F52C12.6 35
  • 50.23 (n)
  • 45.54 (a)
F52C12.6 36
  • 41 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR331C 35
  • 45.64 (n)
  • 38.32 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A09625g 35
  • 43.3 (n)
  • 39.25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BUD32 35
  • 44.76 (n)
  • 40.38 (a)
BUD32 36
  • 32 (a)
OneToOne
BUD32 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G26110 35
  • 49.15 (n)
  • 48.84 (a)
rice
(Oryza sativa)
Liliopsida Os.39261 35
Os10g0422300 35
  • 50.86 (n)
  • 46.95 (a)
corn
(Zea mays)
Liliopsida Zm.16761 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04595 35
  • 53.12 (n)
  • 48.6 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAP27G11.07c 35
  • 48.84 (n)
  • 46.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for TP53RK:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TP53RK Gene

ENSEMBL:
Gene Tree for TP53RK (if available)
TreeFam:
Gene Tree for TP53RK (if available)

Paralogs for TP53RK Gene

No data available for Paralogs for TP53RK Gene

Variants for TP53RK Gene

Sequence variations from dbSNP and Humsavar for TP53RK Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_014427 -
rs11550540 - 46,687,130(-) AGTCC(A/G)CTATG reference, missense
rs34983477 - 46,687,147(+) AATCT(C/T)GAACA reference, missense
rs56008408 - 46,687,082(+) AATTG(C/T)CTTGG reference, missense
rs14872 -- 46,686,851(+) CTTCA(G/T)AAAGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TP53RK Gene

Variant ID Type Subtype PubMed ID
nsv912901 CNV Loss 21882294

Variation tolerance for TP53RK Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TP53RK Gene

Disorders for TP53RK Gene

MalaCards: The human disease database

(1) MalaCards diseases for TP53RK Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
narcolepsy
  • narcolepsy, without cataplexy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TP53RK

Genetic Association Database (GAD)
TP53RK
Human Genome Epidemiology (HuGE) Navigator
TP53RK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TP53RK
genes like me logo Genes that share disorders with TP53RK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TP53RK Gene

Publications for TP53RK Gene

  1. Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes. (PMID: 11546806) Abe Y. … Enomoto Y. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency. (PMID: 12914926) Facchin S. … Pinna L.A. (FEBS Lett. 2003) 2 3 23
  3. Phosphorylation and activation of the atypical kinase p53-related protein kinase (PRPK) by Akt/PKB. (PMID: 17712528) Facchin S. … Pinna L.A. (Cell. Mol. Life Sci. 2007) 3 23
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  5. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3

Products for TP53RK Gene

Sources for TP53RK Gene

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