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Aliases for TP53RK Gene

Aliases for TP53RK Gene

  • TP53 Regulating Kinase 2 3 5
  • Atypical Serine/Threonine Protein Kinase TP53RK 3 4
  • EKC/KEOPS Complex Subunit TP53RK 3 4
  • P53-Related Protein Kinase 3 4
  • EC 2.7.11.1 4 61
  • C20orf64 3 4
  • Nori-2 3 4
  • PRPK 3 4
  • Chromosome 20 Open Reading Frame 64 2
  • TP53-Regulating Kinase 3
  • EC 3.6.-.- 4
  • Nori-2p 3
  • DJ101A2 3
  • BUD32 3

External Ids for TP53RK Gene

Previous HGNC Symbols for TP53RK Gene

  • C20orf64

Previous GeneCards Identifiers for TP53RK Gene

  • GC20M045998
  • GC20M044746
  • GC20M045313
  • GC20M042054

Summaries for TP53RK Gene

GeneCards Summary for TP53RK Gene

TP53RK (TP53 Regulating Kinase) is a Protein Coding gene. Diseases associated with TP53RK include Narcolepsy. Among its related pathways are tRNA processing and P38 MAPK Signaling Pathway (sino). GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity.

UniProtKB/Swiss-Prot for TP53RK Gene

  • Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates Ser-15 of p53/TP53 protein and may therefore participate in its activation.

Gene Wiki entry for TP53RK Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP53RK Gene

Genomics for TP53RK Gene

Regulatory Elements for TP53RK Gene

Enhancers for TP53RK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F047342 1.3 FANTOM5 ENCODE 47.4 -663.4 -663380 21.0 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 TP53RK LOC100419565 SLC2A10 GAPDHP54 ENSG00000234967 ENSG00000228503 LINC01523 RPL35AP RNU6-497P ZNF663P
GH20F045967 0.2 ENCODE 36.2 +718.9 718906 5.8 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC TBX21 NCOA5 CD40 ZNF335 TP53RK PCIF1 SLC2A10 ENSG00000271984 SYS1 FTLP1 RPL13P2
GH20F045880 0.6 ENCODE 30.3 +808.5 808520 1.4 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 NCOA5 PCIF1 TP53RK CD40 ZNF335 WFDC3 RPS2P7 NEURL2 SLC2A10 SYS1
GH20F045997 1.3 FANTOM5 Ensembl ENCODE 25.5 +690.4 690379 4.8 PKNOX1 ZFP64 ZBTB11 ZEB2 ZNF623 ZNF781 ZNF518A NR2F2 ZNF264 SMARCA4 NCOA5 CD40 ZNF335 TP53RK SLC12A5 WFDC3 ENSG00000204044 PCIF1 DNTTIP1 ENSG00000271984
GH20F045855 0.6 ENCODE 21 +832.4 832439 2.8 PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 NCOA5 TP53RK WFDC3 ZNF335 RPS2P7 ENSG00000271984 PCIF1 PLTP ACOT8 ENSG00000277051
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TP53RK on UCSC Golden Path with GeneCards custom track

Promoters for TP53RK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234920 579 2801 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207

Genomic Location for TP53RK Gene

Chromosome:
20
Start:
46,684,365 bp from pter
End:
46,689,779 bp from pter
Size:
5,415 bases
Orientation:
Minus strand

Genomic View for TP53RK Gene

Genes around TP53RK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TP53RK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TP53RK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53RK Gene

Proteins for TP53RK Gene

  • Protein details for TP53RK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S44-PRPK_HUMAN
    Recommended name:
    TP53-regulating kinase
    Protein Accession:
    Q96S44
    Secondary Accessions:
    • B3KU44
    • Q3T977
    • Q5JZ01
    • Q6NZ60
    • Q96FM7
    • Q9NQE6

    Protein attributes for TP53RK Gene

    Size:
    253 amino acids
    Molecular mass:
    28160 Da
    Quaternary structure:
    • Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes. Interacts with TPRKB.
    Miscellaneous:
    • This protein is considered an atypical serine/threonine kinase, because it lacks the conventional structural elements necessary for the substrate recognition as well as a lysine residue that in all other serine/threonine kinases participates in the catalytic event. TP53RK has protein kinase activity in vitro, but in the context of the EKC/KEOPS complex, the catalytic subunit OSGEP switches the activity of TP53RK from kinase into ATPase (By similarity).

neXtProt entry for TP53RK Gene

Selected DME Specific Peptides for TP53RK Gene

Q96S44:
  • VDLYVLE
  • VRLRGRK
  • RGRKRSM

Post-translational modifications for TP53RK Gene

  • Ubiquitination at Lys 40
  • Modification sites at PhosphoSitePlus

Other Protein References for TP53RK Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TP53RK Gene

Gene Families for TP53RK Gene

Protein Domains for TP53RK Gene

Suggested Antigen Peptide Sequences for TP53RK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96S44

UniProtKB/Swiss-Prot:

PRPK_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. BUD32 family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. BUD32 family.
genes like me logo Genes that share domains with TP53RK: view

Function for TP53RK Gene

Molecular function for TP53RK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates Ser-15 of p53/TP53 protein and may therefore participate in its activation.

Enzyme Numbers (IUBMB) for TP53RK Gene

Gene Ontology (GO) - Molecular Function for TP53RK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IDA 11546806
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,TAS --
GO:0005515 protein binding IPI 11546806
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TP53RK: view
genes like me logo Genes that share phenotypes with TP53RK: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TP53RK

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TP53RK Gene

Localization for TP53RK Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP53RK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TP53RK Gene COMPARTMENTS Subcellular localization image for TP53RK gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for TP53RK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000408 EKC/KEOPS complex IBA --
GO:0005634 nucleus IEA,IDA 11546806
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TP53RK: view

Pathways & Interactions for TP53RK Gene

genes like me logo Genes that share pathways with TP53RK: view

SIGNOR curated interactions for TP53RK Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TP53RK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 11546806
GO:0008033 tRNA processing IEA --
GO:0016310 phosphorylation IEA --
GO:0070525 tRNA threonylcarbamoyladenosine metabolic process IBA --
GO:1901796 regulation of signal transduction by p53 class mediator TAS --
genes like me logo Genes that share ontologies with TP53RK: view

Drugs & Compounds for TP53RK Gene

(1) Drugs for TP53RK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for TP53RK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with TP53RK: view

Transcripts for TP53RK Gene

mRNA/cDNA for TP53RK Gene

Unigene Clusters for TP53RK Gene

TP53 regulating kinase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TP53RK Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1:
SP2:

Relevant External Links for TP53RK Gene

GeneLoc Exon Structure for
TP53RK
ECgene alternative splicing isoforms for
TP53RK

Expression for TP53RK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TP53RK Gene

Protein differential expression in normal tissues from HIPED for TP53RK Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TP53RK Gene



Protein tissue co-expression partners for TP53RK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TP53RK Gene:

TP53RK

SOURCE GeneReport for Unigene cluster for TP53RK Gene:

Hs.440263

mRNA Expression by UniProt/SwissProt for TP53RK Gene:

Q96S44-PRPK_HUMAN
Tissue specificity: Highly expressed in testis. Weakly expressed in heart kidney and spleen.
genes like me logo Genes that share expression patterns with TP53RK: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TP53RK Gene

Orthologs for TP53RK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TP53RK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TP53RK 34 35
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia TP53RK 34 35
  • 92.32 (n)
cow
(Bos Taurus)
Mammalia TP53RK 34 35
  • 90.81 (n)
mouse
(Mus musculus)
Mammalia 2810408M09Rik 35
  • 85 (a)
OneToMany
Trp53rk 34 35
  • 84.83 (n)
Trp53rkb 16
rat
(Rattus norvegicus)
Mammalia Tp53rk 34
  • 84.98 (n)
oppossum
(Monodelphis domestica)
Mammalia TP53RK 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves TP53RK 34 35
  • 72.55 (n)
lizard
(Anolis carolinensis)
Reptilia TP53RK 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tp53rk 34
  • 68.17 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17259 34
zebrafish
(Danio rerio)
Actinopterygii tp53rk 34 35
  • 64.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10673 34 35
  • 53.36 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007476 34
  • 50.31 (n)
worm
(Caenorhabditis elegans)
Secernentea F52C12.6 34 35
  • 50.23 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR331C 34
  • 45.64 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BUD32 34 35 37
  • 44.76 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A09625g 34
  • 43.3 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G26110 34
  • 49.15 (n)
rice
(Oryza sativa)
Liliopsida Os10g0422300 34
  • 50.86 (n)
Os.39261 34
corn
(Zea mays)
Liliopsida Zm.16761 34
bread mold
(Neurospora crassa)
Ascomycetes NCU04595 34
  • 53.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAP27G11.07c 34
  • 48.84 (n)
Species where no ortholog for TP53RK was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TP53RK Gene

ENSEMBL:
Gene Tree for TP53RK (if available)
TreeFam:
Gene Tree for TP53RK (if available)

Paralogs for TP53RK Gene

No data available for Paralogs for TP53RK Gene

Variants for TP53RK Gene

Sequence variations from dbSNP and Humsavar for TP53RK Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1004843 -- 46,683,972(-) cctga(C/T)tgttt intron-variant, downstream-variant-500B
rs10605022 -- 46,690,343(+) CACAC(-/TC)ACACA upstream-variant-2KB
rs111608451 -- 46,688,545(+) TATTG(G/T)GCACT intron-variant
rs112128065 -- 46,684,153(+) TCGCA(A/C)GCCAC intron-variant, downstream-variant-500B
rs112448714 -- 46,690,343(+) CACAC(A/T)CACAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TP53RK Gene

Variant ID Type Subtype PubMed ID
nsv1061899 CNV loss 25217958

Variation tolerance for TP53RK Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TP53RK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TP53RK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TP53RK Gene

Disorders for TP53RK Gene

MalaCards: The human disease database

(1) MalaCards diseases for TP53RK Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
narcolepsy
  • narcolepsy, without cataplexy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TP53RK

Genetic Association Database (GAD)
TP53RK
Human Genome Epidemiology (HuGE) Navigator
TP53RK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TP53RK
genes like me logo Genes that share disorders with TP53RK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TP53RK Gene

Publications for TP53RK Gene

  1. Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes. (PMID: 11546806) Abe Y. … Enomoto Y. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency. (PMID: 12914926) Facchin S. … Pinna L.A. (FEBS Lett. 2003) 2 3 22 64
  3. The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME. (PMID: 22912744) Costessi A. … Stunnenberg H.G. (PLoS ONE 2012) 3 4 64
  4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64
  5. Phosphorylation and activation of the atypical kinase p53-related protein kinase (PRPK) by Akt/PKB. (PMID: 17712528) Facchin S. … Pinna L.A. (Cell. Mol. Life Sci. 2007) 3 22 64

Products for TP53RK Gene

Sources for TP53RK Gene

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