TP53RK Gene
protein-coding GIFtS: 52
GCID: GC20M045313
|
|
TP53 regulating kinase(Previous name: chromosome 20 open reading frame 64 )
(Previous symbol: C20orf64)
| |
Aliases
for TP53RK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TP53 Regulating Kinase1 2 | | EC 2.7.11.13 8 | | C20orf641 2 3 | | Chromosome 20 Open Reading Frame 641 | | BUD321 2 | | DJ101A2.21 | | Nori-2p1 2 | | Prpk1 | | Nori-22 3 | | DJ101A21 | | PRPK2 3 | | TP53-Regulating Kinase2 | | P53-Related Protein Kinase2 3 | | |
Export aliases for TP53RK gene to outside databasesPrevious GC identifers: GC20M045998 GC20M044746 GC20M042054 |
Summaries
for TP53RK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PRPK_HUMAN, Q96S44Function: Protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in itsactivation
Gene Wiki entry for TP53RK
|
Genomic Views
for TP53RK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TP53RK gene promoter:
GR AML1a GR-beta FOXD3 E47 POU2F1 POU2F1a FOXO4 STAT3 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for TP53RK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP53RK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.2 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.2TP53RK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M045313: view genomic region
(about GC identifiers)
Start:
|
45,313,004 bp from pter |
End:
|
45,318,418 bp from pter |
Size:
|
5,415 bases |
Orientation:
|
minus strand |
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Proteins
for TP53RK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PRPK_HUMAN, Q96S44 (See
protein sequence)Recommended Name: TP53-regulating kinase Size: 253 amino acids; 28160 Da
Subunit: Interacts with TPRKB
Subcellular location: Nucleus
Secondary accessions: B3KU44 Q3T977 Q5JZ01 Q6NZ60 Q96FM7 Q9NQE6Explore the universe of human proteins at neXtProt for TP53RK: NX_Q96S44
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96S44
3 DME Specific Peptides for TP53RK (Q96S44)
TP53RK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_291028.3
ENSEMBL proteins: ENSP00000361186 ENSP00000361174
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TP53RK for ontologies About GeneDecksing
TP53RK Antibody Products:
Assay Products for TP53RK: |
Protein
Domains /
Families
for TP53RK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TP53RK for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96S44ProtoNet protein and cluster: Q96S44 UniProtKB/Swiss-Prot: PRPK_HUMAN, Q96S44Similarity: Belongs to the protein kinase superfamilySimilarity: Contains 1 protein kinase domain |
Function
for TP53RK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PRPK_HUMAN, Q96S44Function: Protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in itsactivationCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.11 2
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP53RK (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for TP53RK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53RK |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53RK |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
TP53RK for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TP53RK:
|
Pathways & Interactions
for TP53RK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TP53RK
STRING Interaction
Network Preview (showing 5 interactants - click image to see 20)
5/51 Interacting proteins for TP53RK (Q96S443 ENSP000003611864) via UniProtKB, MINT, STRING, and/or I2D (see all 51)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006468 | protein phosphorylation |
IDA | 11546806 | | GO:0009103 | lipopolysaccharide biosynthetic process |
IEA | -- |
TP53RK for ontologies About GeneDecksing
|
Drugs & Compounds
for TP53RK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TP53RK
2 HMDB Compounds for TP53RK About this table
Search CenterWatch for drugs/clinical trials and news about TP53RK / PRPK
|
Transcripts
for TP53RK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TP53RK gene: NM_033550.3 Unigene Cluster for TP53RK: TP53 regulating kinase Hs.440263 [show with all ESTs]Unigene Representative Sequence: NM_0335502 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372114(uc002xsj.3 uc002xsk.3) ENST00000372102
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TP53RK (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP53RK (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TP53RK (NM_033550) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TP53RK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53RK |
Additional cDNA sequence: AB017505.2 AB065434.1 AK096502.1 AK315182.1 BC009727.1 BC010637.1 BC019621.1 BC035461.1 BC066309.1 8 DOTS entries: DT.312275 DT.97818172 DT.95145981 DT.92428013 DT.95164077 DT.97783906 DT.420945 DT.95274223 24/348 AceView cDNA sequences (see all 348): BM674579 AI889233 NM_033550 BE048937 AJ713978 BC010637 BM477179 CB118487 BM477349 BM052824 BU553538 AI282453 CA396775 CB048855 AI201331 BM461920 CB163315 AI304605 CD672257 AI758242 BI825806 BI765509 BC035461 AW138748
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for TP53RK About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | |
ECgene alternative splicing isoforms for TP53RK
|
Expression
for TP53RK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TP53RK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAACTGTG
About this image
See TP53RK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TP53RK
SOURCE GeneReport for Unigene cluster: Hs.440263
UniProtKB/Swiss-Prot: PRPK_HUMAN, Q96S44Tissue specificity: Highly expressed in testis. Weakly expressed in heart kidney and spleen
SABiosciences Custom PCR Arrays for TP53RK
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TP53RK
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53RK |
Orthologs
for TP53RK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TP53RK gene from 10/35 species (see all 35) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Trp53rk1 , 5 |
transformation related protein 53 regulating kinase1, 5 |
83.75(n)1
85.95(a)1 |
|
2 (87.22 cM)5
763671 NM_023815.41 NP_076304.21
1667925315 |
chicken
(Gallus gallus) |
Aves |
TP53RK1 |
TP53 regulating kinase |
69.51(n)
68.7(a) |
|
428145 XM_425703.3 XP_425703.3 |
lizard
(Anolis carolinensis) |
Reptilia |
TP53RK6 |
-- |
66(a) |
1 ↔ 1 |
4(144672391-144675751) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.172592 |
Xenopus laevis transcribed sequence with moderate similarity more |
75.71(n) |
|
CF522117.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
570547802 |
-- |
71.14(n) |
|
57054780 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG106731 |
CG10673 |
52.6(n)
46.79(a) |
|
38600 NM_139691.2 NP_647948.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
F52C12.66 |
-- |
40(a) |
1 ↔ 1 |
IV(1956725-1959725) |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
BUD32(YGR262C)4
BUD321 |
Protein kinase, component of the EKC/KEOPS complex more4
Bud32p1 |
44.08(n)1
39.25(a)1 |
|
7(1017759-1016974)4
8531781, 4 NP_011778.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G261101 |
TP53 regulating kinase |
49.15(n)
48.84(a) |
|
832680 NM_122512.3 NP_568482.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.392612 |
Oryza sativa (japonica cultivar-group) putative endopeptidase more |
73.3(n) |
|
NM_196549.1 |
ENSEMBL Gene Tree for TP53RK (if available)
TreeFam Gene Tree for TP53RK (if available) |
Paralogs
for TP53RK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TP53RK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TP53RK (45313004 - 45318418 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TP53RK: --
Human Gene Mutation Database (HGMD): TP53RK
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TP53RK |
|
Disorders
/ Diseases
for TP53RK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TP53RK for disorders About GeneDecksing
OMIM gene information: 608679
OMIM disorders: --
2  diseases for TP53RK: About MalaCardsmalaria alcoholism
Human Genome Epidemiology (HuGE) Navigator: TP53RK (2 documents)
Export disorders for TP53RK gene to outside databases
|
Publications
for TP53RK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TP53RK gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with TP53RK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes. (PubMed id 11546806)1, 2, 3, 9 Abe Y.... Enomoto Y. (2001)
- Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency. (PubMed id 12914926)1, 3, 9 Facchin S....Pinna L.A. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Identification of CGI-121, a novel PRPK (p53-related protein kinase)- binding protein. (PubMed id 12659830)1, 2 Miyoshi A.... Ueda N. (2003)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Phosphorylation and activation of the atypical kinase p53-related protein kinase (PRPK) by Akt/PKB. (PubMed id 17712528)1, 9 Facchin S....Pinna L.A. (2007)
- The human EKC/KEOPS complex is recruited to Cullin2 ub iquitin ligases by the human tumour antigen PRAME. (PubMed id 22912744)1 Costessi A....Stunnenberg H.G. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
|
External Searches for TP53RK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TP53RK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TP53RK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TP53RK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TP53RK | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TP53RK gene:
Search GeneIP for patents involving TP53RK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TP53RK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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