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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TP53INP2 Gene

protein-coding   GIFtS: 44
GCID: GC20P033292

Tumor Protein P53 Inducible Nuclear Protein 2

(Previous name: chromosome 20 open reading frame 110)
(Previous symbol: C20orf110)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Protein P53 Inducible Nuclear Protein 21 2     P53-Inducible Protein U2 3
C20orf1101 2 3     Chromosome 20 Open Reading Frame 1101
Diabetes And Obesity Regulated1 2     dJ1181N3.12
DOR2 3     Diabetes And Obesity-Regulated2
PIG-U2 3     Tumor Protein P53-Inducible Nuclear Protein 22
PINH2 3     Diabetes And Obesity-Regulated Gene3

External Ids:    HGNC: 161041   Entrez Gene: 584762   Ensembl: ENSG000000788047   UniProtKB: Q8IXH63   

Export aliases for TP53INP2 gene to outside databases

Previous GC identifers: GC20P034008 GC20P032755 GC20P030071


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TP53INP2 Gene: 
TP53INP2 (tumor protein p53 inducible nuclear protein 2) is a protein-coding gene. Diseases associated with TP53INP2 include achalasia, and obesity. GO annotations related to this gene include protein binding. An important paralog of this gene is TP53INP1.

UniProtKB/Swiss-Prot: T53I2_HUMAN, Q8IXH6
Function: Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for
autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and
GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the
BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator
of THRA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TP53INP2 gene promoter:
         AhR   PPAR-alpha   p53   RREB-1   STAT3   Nkx2-5   Nkx5-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): TP53INP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TP53INP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP53INP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.22   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.22

TP53INP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP53INP2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P033292:  view genomic region     (about GC identifiers)

Start:
33,292,094 bp from pter      End:
33,301,243 bp from pter
Size:
9,150 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T53I2_HUMAN, Q8IXH6 (See protein sequence)
Recommended Name: Tumor protein p53-inducible nuclear protein 2  
Size: 220 amino acids; 23980 Da
Subunit: Interacts with VMP1, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, MAP1LC3C and THRA
Subcellular location: Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome.
Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to
autophagosomes on autophagy activation
Secondary accessions: A8K8S8 E1P5P6 Q5JX64 Q8IYL5 Q9NU00

Explore the universe of human proteins at neXtProt for TP53INP2: NX_Q8IXH6

Explore proteomics data for TP53INP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IXH6

  • TP53INP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TP53INP2 Protein Expression
    REFSEQ proteins: NP_067025.1  
    ENSEMBL proteins: 
     ENSP00000363943   ENSP00000363942   ENSP00000395784   ENSP00000404410  

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    Cloud-Clone Corp. Proteins for TP53INP2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19056683
    GO:0005776autophagic vacuole IDA19056683
    GO:0005829cytosol IDA--
    GO:0016605PML body IEA--
    GO:0031410cytoplasmic vesicle IEA--

    TP53INP2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8IXH6

    UniProtKB/Swiss-Prot: T53I2_HUMAN, Q8IXH6
    Domain: The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A,
    MAP1LC3B and MAP1LC3C


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T53I2_HUMAN, Q8IXH6
    Function: Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for
    autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and
    GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the
    BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator
    of THRA

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19056683
         
    TP53INP2 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TP53INP2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for TP53INP2 (Q8IXH62, 3 ENSP000003639424) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPL2P605202, 3, ENSP000000372434MINT-7714281 I2D: score=2 STRING: ENSP00000037243
    MAP1LC3AQ9H4923I2D: score=2 
    GABARAPO951663I2D: score=1 
    --Q6XVN82MINT-7715069 MINT-7715023
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly IDA19056683
    GO:0001649osteoblast differentiation IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0010508positive regulation of autophagy IMP--
    GO:0045893positive regulation of transcription, DNA-dependent IDA--

    TP53INP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TP53INP2 (T53I2)

    Search CenterWatch for drugs/clinical trials and news about TP53INP2 / T53I2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TP53INP2 gene: 
    NM_021202.1  

    Unigene Cluster for TP53INP2:

    Tumor protein p53 inducible nuclear protein 2
    Hs.516994  [show with all ESTs]
    Unigene Representative Sequence: AY422170
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374810(uc002xau.1) ENST00000374809 ENST00000451665 ENST00000414082

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    hsa-miR-520e hsa-miR-642a hsa-miR-3938 hsa-miR-106a hsa-miR-4272 hsa-miR-218-1* hsa-miR-632 hsa-miR-3921
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    Additional mRNA sequence: 

    AJ297792.1 AK025412.1 AK027153.1 AK292443.1 AL122050.1 AL137597.1 AY422170.1 BC035639.1 
    BC128251.1 

    7 DOTS entries:

    DT.97847173  DT.453130  DT.120800630  DT.40246546  DT.120800552  DT.40263923  DT.87078911 

    24/237 AceView cDNA sequences (see all 237):

    AA085876 AL122050 BG059576 AJ297792 BM994712 NM_021202 AI801801 BQ185497 
    AA411073 BQ638027 AY422170 BM464419 AA436690 AI927754 CB164452 AA282010 
    BM979145 BI039274 AA442493 N72297 AA910305 N34860 BM511704 AI281751 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TP53INP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGTGTATG
    TP53INP2 Expression
    About this image


    See TP53INP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TP53INP2

    SOURCE GeneReport for Unigene cluster: Hs.516994
        SABiosciences Custom PCR Arrays for TP53INP2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TP53INP2 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trp53inp21 , 5 transformation related protein 53 inducible nuclear more1, 5 83.94(n)1
    85.91(a)1
      2 (77.26 cM)5
    687281  NM_178111.31  NP_835212.11 
     1553810595 
    chicken
    (Gallus gallus)
    Aves TP53INP21 tumor protein p53 inducible nuclear protein 2 66.67(n)
    58.45(a)
      769066  XM_001232257.1  XP_001232258.1 
    lizard
    (Anolis carolinensis)
    Reptilia TP53INP26
    tumor protein p53 inducible nuclear protein 2
    53(a)
    1 ↔ 1
    4(138376153-138414693)
    zebrafish
    (Danio rerio)
    Actinopterygii TP53INP26
    tumor protein p53 inducible nuclear protein 2
    38(a)
    1 ↔ 1
    23(2555121-2560985)
    fruit fly
    (Drosophila melanogaster)
    Insecta DOR6
    --
    12(a)
    1 → many
    3L(4406943-4420648)


    ENSEMBL Gene Tree for TP53INP2 (if available)
    TreeFam Gene Tree for TP53INP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TP53INP2 gene
    TP53INP12  
    1 SIMAP similar gene for TP53INP2 using alignment to 3 protein entries:     T53I2_HUMAN (see all proteins):
    TP53INP1

    TP53INP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/226 SNPs in TP53INP2 are shown (see all 226)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2005202911,2
    C--30069249(+) GGCTGG/TGATGG 1 -- us2k10--------
    rs1396738831,2
    --33290160(+) AGAGGC/TTCAGA 1 -- us2k10--------
    rs1897068471,2
    --33290182(+) TGAGGA/TCACTT 1 -- us2k10--------
    rs1114133701,2
    C,F--33290192(+) TTGGGC/TATAAC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1437038431,2
    --33290343(+) GCCGGA/GCACGG 1 -- us2k10--------
    rs1861972691,2
    --33290425(+) CATCCC/TGGCTA 1 -- us2k10--------
    rs3773698441,2
    C--33290484(+) GGTAGC/TGGCGC 1 -- us2k10--------
    rs1906166851,2
    C--33290485(+) GTAGCA/GGGCGC 1 -- us2k10--------
    rs1505932491,2
    C--33290533(+) ATGGCA/GTGAAC 1 -- us2k10--------
    rs1820429641,2
    C--33290570(+) GAGATC/TGTGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TP53INP2 (33292094 - 33301243 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TP53INP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv819225CNV Loss19587683

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for TP53INP2:    About MalaCards
    achalasia    obesity    ataxia    thyroiditis


    TP53INP2 for disorders           About GeneDecksing


    Export disorders for TP53INP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TP53INP2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with TP53INP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription. (PubMed id 22470510)1, 2 Sancho A.... Zorzano A. (2012)
    2. The TP53INP2 protein is required for autophagy in mammalian cells. (PubMed id 19056683)1, 2 Nowak J....Iovanna J.L. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. DOR undergoes nucleo-cytoplasmic shuttling, which invo lves passage through the nucleolus. (PubMed id 22750142)1 Mauvezin C....Zorzano A. (2012)
    7. Role of diabetes- and obesity-related protein in the regulation of osteoblast differentiation. (PubMed id 21467300)1 Linares G.R....Mohan S. (2011)
    8. TP53INP2 is the new guest at the table of self-eating. (PubMed id 19145107)2 Nowak J. and Iovanna J.L. (2009)
    9. hnRNP A2 regulates alternative mRNA splicing of TP53I NP2 to control invasive cell migration. (PubMed id 19934309)1 Moran-Jones K....Norman J.C. (2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58476 HGNC: 16104 AceView: TP53INP2 Ensembl:ENSG00000078804 euGenes: HUgn58476
    ECgene: TP53INP2 H-InvDB: TP53INP2

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TP53INP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TP53INP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
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    Patent Information for TP53INP2 gene:
    Search GeneIP for patents involving TP53INP2

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