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Aliases for TP53INP2 Gene

Aliases for TP53INP2 Gene

  • Tumor Protein P53 Inducible Nuclear Protein 2 2 3
  • Diabetes And Obesity Regulated 2 3
  • P53-Inducible Protein U 3 4
  • C20orf110 3 4
  • PIG-U 3 4
  • PINH 3 4
  • DOR 3 4
  • Tumor Protein P53-Inducible Nuclear Protein 2 3
  • Chromosome 20 Open Reading Frame 110 2
  • Diabetes And Obesity-Regulated Gene 4
  • Diabetes And Obesity-Regulated 3
  • DJ1181N3.1 3

External Ids for TP53INP2 Gene

Previous HGNC Symbols for TP53INP2 Gene

  • C20orf110

Previous GeneCards Identifiers for TP53INP2 Gene

  • GC20P034008
  • GC20P032755
  • GC20P033292
  • GC20P030071

Summaries for TP53INP2 Gene

GeneCards Summary for TP53INP2 Gene

TP53INP2 (Tumor Protein P53 Inducible Nuclear Protein 2) is a Protein Coding gene. Diseases associated with TP53INP2 include obesity. An important paralog of this gene is TP53INP1.

UniProtKB/Swiss-Prot for TP53INP2 Gene

  • Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP53INP2 Gene

Genomics for TP53INP2 Gene

Regulatory Elements for TP53INP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TP53INP2 Gene

Start:
34,704,290 bp from pter
End:
34,713,439 bp from pter
Size:
9,150 bases
Orientation:
Plus strand

Genomic View for TP53INP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TP53INP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53INP2 Gene

Proteins for TP53INP2 Gene

  • Protein details for TP53INP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXH6-T53I2_HUMAN
    Recommended name:
    Tumor protein p53-inducible nuclear protein 2
    Protein Accession:
    Q8IXH6
    Secondary Accessions:
    • A8K8S8
    • E1P5P6
    • Q5JX64
    • Q8IYL5
    • Q9NU00

    Protein attributes for TP53INP2 Gene

    Size:
    220 amino acids
    Molecular mass:
    23980 Da
    Quaternary structure:
    • Interacts with VMP1, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, MAP1LC3C and THRA.

neXtProt entry for TP53INP2 Gene

Proteomics data for TP53INP2 Gene at MOPED

Post-translational modifications for TP53INP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TP53INP2 Gene

No data available for DME Specific Peptides for TP53INP2 Gene

Domains for TP53INP2 Gene

Protein Domains for TP53INP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TP53INP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXH6

UniProtKB/Swiss-Prot:

T53I2_HUMAN :
  • Q8IXH6
Domain:
  • The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C
genes like me logo Genes that share domains with TP53INP2: view

No data available for Gene Families for TP53INP2 Gene

Function for TP53INP2 Gene

Molecular function for TP53INP2 Gene

UniProtKB/Swiss-Prot Function: Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.

Gene Ontology (GO) - Molecular Function for TP53INP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19056683
genes like me logo Genes that share ontologies with TP53INP2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TP53INP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TP53INP2 Gene

Localization for TP53INP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP53INP2 Gene

Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TP53INP2 Gene COMPARTMENTS Subcellular localization image for TP53INP2 gene
Compartment Confidence
cytosol 5
nucleus 5
vacuole 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TP53INP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19056683
GO:0005776 autophagic vacuole IDA 19056683
GO:0005829 cytosol IDA 22470510
GO:0016605 PML body IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with TP53INP2: view

Pathways for TP53INP2 Gene

SuperPathways for TP53INP2 Gene

No Data Available

Interacting Proteins for TP53INP2 Gene

Gene Ontology (GO) - Biological Process for TP53INP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IDA 19056683
GO:0001649 osteoblast differentiation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0010508 positive regulation of autophagy IMP 22470510
GO:0045893 positive regulation of transcription, DNA-templated IDA 22470510
genes like me logo Genes that share ontologies with TP53INP2: view

No data available for Pathways by source for TP53INP2 Gene

Transcripts for TP53INP2 Gene

Unigene Clusters for TP53INP2 Gene

Tumor protein p53 inducible nuclear protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TP53INP2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TP53INP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TP53INP2 Gene

No ASD Table

Relevant External Links for TP53INP2 Gene

GeneLoc Exon Structure for
TP53INP2
ECgene alternative splicing isoforms for
TP53INP2

Expression for TP53INP2 Gene

mRNA expression in normal human tissues for TP53INP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TP53INP2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (11.9) and Brain - Substantia nigra (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TP53INP2 Gene

SOURCE GeneReport for Unigene cluster for TP53INP2 Gene Hs.516994

genes like me logo Genes that share expressions with TP53INP2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TP53INP2 Gene

Orthologs for TP53INP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TP53INP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TP53INP2 35
  • 99.24 (n)
  • 98.18 (a)
TP53INP2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TP53INP2 35
  • 86.82 (n)
  • 85.91 (a)
TP53INP2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TP53INP2 35
  • 91.67 (n)
  • 90 (a)
TP53INP2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trp53inp2 35
  • 83.79 (n)
  • 85.45 (a)
Trp53inp2 16
Trp53inp2 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TP53INP2 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tp53inp2 35
  • 84.55 (n)
  • 85.91 (a)
chicken
(Gallus gallus)
Aves TP53INP2 35
  • 67.31 (n)
  • 57 (a)
lizard
(Anolis carolinensis)
Reptilia TP53INP2 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tp53inp2 35
  • 56.63 (n)
  • 50 (a)
zebrafish
(Danio rerio)
Actinopterygii TP53INP2 36
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta DOR 36
  • 14 (a)
OneToMany
Species with no ortholog for TP53INP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TP53INP2 Gene

ENSEMBL:
Gene Tree for TP53INP2 (if available)
TreeFam:
Gene Tree for TP53INP2 (if available)

Paralogs for TP53INP2 Gene

Paralogs for TP53INP2 Gene

Selected SIMAP similar genes for TP53INP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TP53INP2: view

Variants for TP53INP2 Gene

Sequence variations from dbSNP and Humsavar for TP53INP2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs13902 -- 34,713,408(-) TGTTT(G/T)TCTTT utr-variant-3-prime
rs910869 -- 34,704,973(+) GACAG(C/T)ACCAG intron-variant
rs910870 -- 34,705,089(+) ACTCC(C/T)AGACC intron-variant
rs1062820 -- 34,711,371(+) AGCAG(G/T)GATGC utr-variant-3-prime
rs2378256 -- 34,704,323(+) GTGCC(C/G/T)TGAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TP53INP2 Gene

Variant ID Type Subtype PubMed ID
nsv819225 CNV Loss 19587683

Relevant External Links for TP53INP2 Gene

HapMap Linkage Disequilibrium report
TP53INP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TP53INP2 Gene

Disorders for TP53INP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TP53INP2 Gene including...

Search for TP53INP2 Gene in MalaCards »
genes like me logo Genes that share disorders with TP53INP2: view

No data available for UniProtKB/Swiss-Prot for TP53INP2 Gene

Publications for TP53INP2 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The TP53INP2 protein is required for autophagy in mammalian cells. (PMID: 19056683) Nowak J. … Iovanna J.L. (Mol. Biol. Cell 2009) 3 4
  5. DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription. (PMID: 22470510) Sancho A. … Zorzano A. (PLoS ONE 2012) 3 4

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