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TP53INP2 Gene

protein-coding   GIFtS: 46
GCID: GC20P033292

Tumor Protein P53 Inducible Nuclear Protein 2

(Previous name: chromosome 20 open reading frame 110)
(Previous symbol: C20orf110)
  See TP53INP2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Tumor Protein P53 Inducible Nuclear Protein 21 2     P53-Inducible Protein U2 3
C20orf1101 2 3     Chromosome 20 Open Reading Frame 1101
Diabetes And Obesity Regulated1 2     dJ1181N3.12
DOR2 3     Diabetes And Obesity-Regulated2
PIG-U2 3     Tumor Protein P53-Inducible Nuclear Protein 22
PINH2 3     Diabetes And Obesity-Regulated Gene3

External Ids:    HGNC: 161041   Entrez Gene: 584762   Ensembl: ENSG000000788047   UniProtKB: Q8IXH63   
ORGUL members:         

Export aliases for TP53INP2 gene to outside databases

Previous GC identifers: GC20P034008 GC20P032755 GC20P030071


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TP53INP2 Gene:
TP53INP2 (tumor protein p53 inducible nuclear protein 2) is a protein-coding gene. Diseases associated with TP53INP2 include obesity. An important paralog of this gene is TP53INP1.

UniProtKB/Swiss-Prot: T53I2_HUMAN, Q8IXH6
Function: Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for
autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and
GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the
BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator
of THRA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TP53INP2 gene promoter:
         AhR   PPAR-alpha   p53   RREB-1   STAT3   Nkx2-5   Nkx5-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): TP53INP2 promoter sequence
   Search Chromatin IP Primers for TP53INP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TP53INP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.22   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.22

TP53INP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP53INP2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P033292:  view genomic region     (about GC identifiers)

Start:
33,292,094 bp from pter      End:
33,301,243 bp from pter
Size:
9,150 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: T53I2_HUMAN, Q8IXH6 (See protein sequence)
Recommended Name: Tumor protein p53-inducible nuclear protein 2  
Size: 220 amino acids; 23980 Da
Subunit: Interacts with VMP1, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, MAP1LC3C and THRA
Secondary accessions: A8K8S8 E1P5P6 Q5JX64 Q8IYL5 Q9NU00

Explore the universe of human proteins at neXtProt for TP53INP2: NX_Q8IXH6

Explore proteomics data for TP53INP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TP53INP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067025.1  
    ENSEMBL proteins: 
     ENSP00000363943   ENSP00000363942   ENSP00000395784   ENSP00000404410  

    TP53INP2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8IXH6

    UniProtKB/Swiss-Prot: T53I2_HUMAN, Q8IXH6
    Domain: The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A,
    MAP1LC3B and MAP1LC3C


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T53I2_HUMAN, Q8IXH6
    Function: Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for
    autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and
    GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the
    BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator
    of THRA

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19056683
         
    Find genes that share ontologies with TP53INP2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TP53INP2
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    Selected qRT-PCR Assays for microRNAs that regulate TP53INP2 (see all 99):
    hsa-miR-520e hsa-miR-642a hsa-miR-3938 hsa-miR-106a hsa-miR-4272 hsa-miR-218-1* hsa-miR-632 hsa-miR-3921
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T53I2_HUMAN, Q8IXH6: Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome.
    Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to
    autophagosomes on autophagy activation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    vacuole5
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19056683
    GO:0005776autophagic vacuole IDA19056683
    GO:0005829cytosol IDA--
    GO:0016605PML body IEA--
    GO:0031410cytoplasmic vesicle IEA--

    Find genes that share ontologies with TP53INP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TP53INP2
    Interactions:

        Search GeneGlobe Interaction Network for TP53INP2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for TP53INP2 (Q8IXH62, 3 ENSP000003639424) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPL2P605202, 3, ENSP000000372434MINT-7714281 I2D: score=2 STRING: ENSP00000037243
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=2 STRING: ENSP00000363970
    GABARAPO951663I2D: score=1 
    MAP1LC3BENSP000002686074STRING: ENSP00000268607
    --Q6XVN82MINT-7715069 MINT-7715023
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly IDA19056683
    GO:0001649osteoblast differentiation IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0010508positive regulation of autophagy IMP--
    GO:0045893positive regulation of transcription, DNA-templated IDA--

    Find genes that share ontologies with TP53INP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TP53INP2 (T53I2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TP53INP2 gene: 
    NM_021202.1  

    Unigene Cluster for TP53INP2:

    Tumor protein p53 inducible nuclear protein 2
    Hs.516994  [show with all ESTs]
    Unigene Representative Sequence: AY422170
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374810(uc002xau.1) ENST00000374809 ENST00000451665 ENST00000414082

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TP53INP2 (see all 99):
    hsa-miR-520e hsa-miR-642a hsa-miR-3938 hsa-miR-106a hsa-miR-4272 hsa-miR-218-1* hsa-miR-632 hsa-miR-3921
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      QuantiTect SYBR Green Assays in human, mouse, rat TP53INP2
      QuantiFast Probe-based Assays in human, mouse, rat TP53INP2

    Additional mRNA sequence: 

    AJ297792.1 AK025412.1 AK027153.1 AK292443.1 AL122050.1 AL137597.1 AY422170.1 BC035639.1 
    BC128251.1 

    7 DOTS entries:

    DT.97847173  DT.453130  DT.120800630  DT.40246546  DT.120800552  DT.40263923  DT.87078911 

    Selected AceView cDNA sequences (see all 237):

    NM_021202 BG059576 BQ638027 CA312055 N72297 CB051122 N34860 AI216064 
    AJ297792 N59028 AA282010 AA442493 BM978752 AL122050 BU685591 BM709408 
    AA749410 BM979145 BI039274 AI281751 BQ185497 AA436690 BG573999 BM464419 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TP53INP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGTGTATG
    TP53INP2 Expression
    About this image


    TP53INP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Esophagus (Gastrointestinal Tract)
    TP53INP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TP53INP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516994
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TP53INP2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trp53inp21 , 5 transformation related protein 53 inducible nuclear more1, 5 83.79(n)1
    85.45(a)1
      2 (77.26 cM)5
    687281  NM_178111.31  NP_835212.11 
     1553810595 
    chicken
    (Gallus gallus)
    Aves TP53INP21 tumor protein p53 inducible nuclear protein 2 67.31(n)
    57(a)
      769066  XM_001232257.2  XP_001232258.1 
    lizard
    (Anolis carolinensis)
    Reptilia TP53INP26
    tumor protein p53 inducible nuclear protein 2
    55(a)
    1 ↔ 1
    4(138376153-138414693)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tp53inp21 tumor protein p53 inducible nuclear protein 2 56.63(n)
    50(a)
      100497151  XM_002932876.2  XP_002932922.1 
    zebrafish
    (Danio rerio)
    Actinopterygii TP53INP26
    tumor protein p53 inducible nuclear protein 2
    38(a)
    1 ↔ 1
    23(2555121-2560985) ENSDARG00000089986
    fruit fly
    (Drosophila melanogaster)
    Insecta DOR6
    --
    14(a)
    1 → many
    3L(4406943-4420648)


    ENSEMBL Gene Tree for TP53INP2 (if available)
    TreeFam Gene Tree for TP53INP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TP53INP2 gene
    TP53INP12  
    1 SIMAP similar gene for TP53INP2 using alignment to 3 protein entries:     T53I2_HUMAN (see all proteins):
    TP53INP1

    Find genes that share paralogs with TP53INP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TP53INP2 (see all 226)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2005202911,2
    C--30069249(+) GGCTGG/TGATGG 1 -- us2k10--------
    rs1396738831,2
    --33290160(+) AGAGGC/TTCAGA 1 -- us2k10--------
    rs1897068471,2
    --33290182(+) TGAGGA/TCACTT 1 -- us2k10--------
    rs1114133701,2
    C,F--33290192(+) TTGGGC/TATAAC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1437038431,2
    --33290343(+) GCCGGA/GCACGG 1 -- us2k10--------
    rs1861972691,2
    --33290425(+) CATCCC/TGGCTA 1 -- us2k10--------
    rs3773698441,2
    C--33290484(+) GGTAGC/TGGCGC 1 -- us2k10--------
    rs1906166851,2
    C--33290485(+) GTAGCA/GGGCGC 1 -- us2k10--------
    rs1505932491,2
    C--33290533(+) ATGGCA/GTGAAC 1 -- us2k10--------
    rs1820429641,2
    C--33290570(+) GAGATC/TGTGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TP53INP2 (33292094 - 33301243 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TP53INP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819225CNV Loss19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TP53INP2
    DNA2.0 Custom Variant and Variant Library Synthesis for TP53INP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for TP53INP2:    
    About MalaCards
    obesity


    Find genes that share disorders with TP53INP2           About GenesLikeMe


    Export disorders for TP53INP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TP53INP2 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with TP53INP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription. (PubMed id 22470510)1, 2 Sancho A.... Zorzano A. (PLoS ONE 2012)
    2. The TP53INP2 protein is required for autophagy in mammalian cells. (PubMed id 19056683)1, 2 Nowak J.... Iovanna J.L. (Mol. Biol. Cell 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    6. DOR undergoes nucleo-cytoplasmic shuttling, which involves passage through the nucleolus. (PubMed id 22750142)1 Mauvezin C....Zorzano A. (FEBS Lett. 2012)
    7. Role of diabetes- and obesity-related protein in the regulation of osteoblast differentiation. (PubMed id 21467300)1 Linares G.R....Mohan S. (Am. J. Physiol. Endocrinol. Metab. 2011)
    8. TP53INP2 is the new guest at the table of self-eating. (PubMed id 19145107)2 Nowak J. and Iovanna J.L. (Autophagy 2009)
    9. hnRNP A2 regulates alternative mRNA splicing of TP53INP2 to control invasive cell migration. (PubMed id 19934309)1 Moran-Jones K....Norman J.C. (Cancer Res. 2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 58476 HGNC: 16104 AceView: TP53INP2 Ensembl:ENSG00000078804 euGenes: HUgn58476
    ECgene: TP53INP2 H-InvDB: TP53INP2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TP53INP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TP53INP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TP53INP2 gene:
    Search GeneIP for patents involving TP53INP2

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