Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TP53INP2 Gene

Aliases for TP53INP2 Gene

  • Tumor Protein P53 Inducible Nuclear Protein 2 2 3 5
  • P53-Inducible Protein U 3 4
  • C20orf110 3 4
  • PIG-U 3 4
  • PINH 3 4
  • DOR 3 4
  • Tumor Protein P53-Inducible Nuclear Protein 2 3
  • Chromosome 20 Open Reading Frame 110 2
  • Diabetes And Obesity-Regulated Gene 4
  • Diabetes And Obesity Regulated 2
  • Diabetes And Obesity-Regulated 3
  • DJ1181N3.1 3

External Ids for TP53INP2 Gene

Previous HGNC Symbols for TP53INP2 Gene

  • C20orf110

Previous GeneCards Identifiers for TP53INP2 Gene

  • GC20P034008
  • GC20P032755
  • GC20P033292
  • GC20P030071

Summaries for TP53INP2 Gene

Entrez Gene Summary for TP53INP2 Gene

  • The protein encoded by this gene promotes autophagy and is essential for proper autophagosome formation and processing. In addition, the encoded protein can enhance rDNA transcription by helping in the assembly of the POLR1/RNA polymerase I preinitiation complex. Finally, this protein serves as a transcriptional activator for some genes. [provided by RefSeq, Jul 2016]

GeneCards Summary for TP53INP2 Gene

TP53INP2 (Tumor Protein P53 Inducible Nuclear Protein 2) is a Protein Coding gene. Diseases associated with TP53INP2 include Obesity. Among its related pathways are Autophagy - animal. An important paralog of this gene is TP53INP1.

UniProtKB/Swiss-Prot for TP53INP2 Gene

  • Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP53INP2 Gene

Genomics for TP53INP2 Gene

Regulatory Elements for TP53INP2 Gene

Enhancers for TP53INP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G034570 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13 -133.1 -133053 0.9 HDAC1 PKNOX1 CBX3 ATF1 TCF12 ZNF766 ELK1 SCRT2 FOS ETV6 TP53INP2 GC20M034549 GC20P034589
GH20G034620 1.1 ENCODE 16.5 -82.9 -82857 1.3 FOXA2 ARNT MLX ZFP64 ARID4B SIN3A SLC30A9 ZNF766 ZNF143 FOS PIGU TP53INP2 ENSG00000231034 MAP1LC3A NCOA6 ITCH GC20P034589
GH20G034522 1.6 Ensembl ENCODE dbSUPER 10.6 -179.3 -179264 5.9 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 MAP1LC3A ITCH TP53INP2 ENSG00000231034 PIGU NCOA6 ENSG00000206582 GC20M034527 GC20P034523
GH20G034578 1.4 Ensembl ENCODE dbSUPER 11.3 -123.7 -123699 4.0 HDGF PKNOX1 ARID4B FEZF1 ZNF48 SLC30A9 FOS JUNB REST TBX21 MAP1LC3A PIGU NCOA6 TP53INP2 GC20P034589 GC20M034549
GH20G034514 1.4 ENCODE dbSUPER 10.6 -188.2 -188246 3.1 PKNOX1 MLX CREB3L1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 MAP1LC3A PIGU TRPC4AP ZNF341-AS1 EIF6 NCOA6 TP53INP2 ITCH DYNLRB1 GC20M034509
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TP53INP2 on UCSC Golden Path with GeneCards custom track

Promoters for TP53INP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000136443 10 1401 HDGF FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF143 ZNF207

Genomic Location for TP53INP2 Gene

Chromosome:
20
Start:
34,704,290 bp from pter
End:
34,713,439 bp from pter
Size:
9,150 bases
Orientation:
Plus strand

Genomic View for TP53INP2 Gene

Genes around TP53INP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TP53INP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TP53INP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53INP2 Gene

Proteins for TP53INP2 Gene

  • Protein details for TP53INP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXH6-T53I2_HUMAN
    Recommended name:
    Tumor protein p53-inducible nuclear protein 2
    Protein Accession:
    Q8IXH6
    Secondary Accessions:
    • A8K8S8
    • E1P5P6
    • Q5JX64
    • Q8IYL5
    • Q9NU00

    Protein attributes for TP53INP2 Gene

    Size:
    220 amino acids
    Molecular mass:
    23980 Da
    Quaternary structure:
    • Interacts with VMP1, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, MAP1LC3C and THRA.

neXtProt entry for TP53INP2 Gene

Post-translational modifications for TP53INP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TP53INP2 Gene

Domains & Families for TP53INP2 Gene

Protein Domains for TP53INP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TP53INP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXH6

UniProtKB/Swiss-Prot:

T53I2_HUMAN :
  • The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.
Domain:
  • The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.
genes like me logo Genes that share domains with TP53INP2: view

No data available for Gene Families for TP53INP2 Gene

Function for TP53INP2 Gene

Molecular function for TP53INP2 Gene

UniProtKB/Swiss-Prot Function:
Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.

Gene Ontology (GO) - Molecular Function for TP53INP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19056683
GO:0043130 ubiquitin binding IEA --
genes like me logo Genes that share ontologies with TP53INP2: view
genes like me logo Genes that share phenotypes with TP53INP2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TP53INP2 Gene

Localization for TP53INP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP53INP2 Gene

Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TP53INP2 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TP53INP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 19056683
GO:0005737 cytoplasm IEA --
GO:0005776 autophagosome IEA,IDA 19056683
GO:0005829 cytosol IEA,IDA 22470510
GO:0016605 PML body IEA --
genes like me logo Genes that share ontologies with TP53INP2: view

Pathways & Interactions for TP53INP2 Gene

SuperPathways for TP53INP2 Gene

SuperPathway Contained pathways
1 Autophagy - animal
genes like me logo Genes that share pathways with TP53INP2: view

Pathways by source for TP53INP2 Gene

1 KEGG pathway for TP53INP2 Gene

SIGNOR curated interactions for TP53INP2 Gene

Activates:

Gene Ontology (GO) - Biological Process for TP53INP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IDA 19056683
GO:0001649 osteoblast differentiation IEA --
GO:0001894 tissue homeostasis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TP53INP2: view

Drugs & Compounds for TP53INP2 Gene

No Compound Related Data Available

Transcripts for TP53INP2 Gene

Unigene Clusters for TP53INP2 Gene

Tumor protein p53 inducible nuclear protein 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TP53INP2 Gene

No ASD Table

Relevant External Links for TP53INP2 Gene

GeneLoc Exon Structure for
TP53INP2
ECgene alternative splicing isoforms for
TP53INP2

Expression for TP53INP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TP53INP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TP53INP2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x11.9) and Brain - Substantia nigra (x6.0).

Protein differential expression in normal tissues from HIPED for TP53INP2 Gene

This gene is overexpressed in Lung (31.7), Urinary Bladder (11.1), Colon (9.9), and Ovary (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TP53INP2 Gene



Protein tissue co-expression partners for TP53INP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TP53INP2 Gene:

TP53INP2

SOURCE GeneReport for Unigene cluster for TP53INP2 Gene:

Hs.516994

Evidence on tissue expression from TISSUES for TP53INP2 Gene

  • Eye(4.4)
  • Heart(4.4)
  • Liver(4.3)
  • Nervous system(3.9)
  • Muscle(2.6)
genes like me logo Genes that share expression patterns with TP53INP2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TP53INP2 Gene

Orthologs for TP53INP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TP53INP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TP53INP2 34 35
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia TP53INP2 34 35
  • 91.67 (n)
cow
(Bos Taurus)
Mammalia TP53INP2 34 35
  • 86.82 (n)
rat
(Rattus norvegicus)
Mammalia Tp53inp2 34
  • 84.55 (n)
mouse
(Mus musculus)
Mammalia Trp53inp2 34 16 35
  • 83.79 (n)
oppossum
(Monodelphis domestica)
Mammalia TP53INP2 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves TP53INP2 34
  • 67.31 (n)
lizard
(Anolis carolinensis)
Reptilia TP53INP2 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tp53inp2 34
  • 56.63 (n)
zebrafish
(Danio rerio)
Actinopterygii TP53INP2 35
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta DOR 35
  • 14 (a)
OneToMany
Species where no ortholog for TP53INP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TP53INP2 Gene

ENSEMBL:
Gene Tree for TP53INP2 (if available)
TreeFam:
Gene Tree for TP53INP2 (if available)

Paralogs for TP53INP2 Gene

Paralogs for TP53INP2 Gene

(1) SIMAP similar genes for TP53INP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TP53INP2: view

Variants for TP53INP2 Gene

Sequence variations from dbSNP and Humsavar for TP53INP2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000132520 -- 34,706,772(+) CAGGT(A/G)GATTA intron-variant, upstream-variant-2KB
rs1000496353 -- 34,709,800(+) TGGAG(C/G)GCCTA intron-variant
rs1000560781 -- 34,704,662(+) CCATG(A/T)CGTCG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000653265 -- 34,709,637(+) GAGGG(A/G)GTAGC intron-variant
rs1001015495 -- 34,711,361(+) CAGCG(G/T)GCAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TP53INP2 Gene

Variant ID Type Subtype PubMed ID
nsv1066181 CNV gain 25217958
nsv819225 CNV loss 19587683

Variation tolerance for TP53INP2 Gene

Residual Variation Intolerance Score: 72.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TP53INP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TP53INP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TP53INP2 Gene

Disorders for TP53INP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TP53INP2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TP53INP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TP53INP2
genes like me logo Genes that share disorders with TP53INP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TP53INP2 Gene

Publications for TP53INP2 Gene

  1. DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription. (PMID: 22470510) Sancho A. … Zorzano A. (PLoS ONE 2012) 3 4 64
  2. The TP53INP2 protein is required for autophagy in mammalian cells. (PMID: 19056683) Nowak J. … Iovanna J.L. (Mol. Biol. Cell 2009) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64

Products for TP53INP2 Gene

Sources for TP53INP2 Gene

Content
Loading form....