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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TP53INP1 Gene

protein-coding   GIFtS: 54
GCID: GC08M095938

tumor protein p53 inducible nuclear protein 1
 Explore 11 diseases affiliated with
TP53INP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TP53INP1    

Aliases
for TP53INP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tumor Protein P53 Inducible Nuclear Protein 11 2     P53-Dependent Damage-Inducible Nuclear Protein 12 3
SIP1 2 3     P53DINP11 3 5
P53DINP11 3 5     TP53DINP12 5
TP53INP1A1 2     DKFZp434M13171
TP53INP1B1 2     FLJ221391
Teap1 2     P53-Inducible P53DINP12
Stress-Induced Protein2 3     Tumor Protein P53-Inducible Nuclear Protein 12

External Ids:    HGNC: 180221   Entrez Gene: 942412   Ensembl: ENSG000001649387   OMIM: 6061855   UniProtKB: Q96A563   

Export aliases for TP53INP1 gene to outside databases

Previous GC identifers: GC08M094561 GC08M095909 GC08M095606 GC08M095894 GC08M096007 GC08M091146


Summaries
for TP53INP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: T53I1_HUMAN, Q96A56
Function: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of
transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation
of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP,
GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven
oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS)
regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and
p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA
breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing
cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of
SPARC

Gene Wiki entry for TP53INP1


Genomic Views
for TP53INP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TP53INP1 gene promoter:
         C/EBPbeta   USF1   AML1a   p53   USF2   USF-1:USF-2   Nkx2-5   AREB6   GATA-6   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): TP53INP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TP53INP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP53INP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q22

TP53INP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP53INP1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M095938:  view genomic region     (about GC identifiers)

Start:
 95,938,200 bp from pter      End:
 95,961,639 bp from pter
Size:
 23,440 bases      Orientation:
 minus strand

Proteins
for TP53INP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: T53I1_HUMAN, Q96A56 (See protein sequence)
Recommended Name: Tumor protein p53-inducible nuclear protein 1  
Size: 240 amino acids; 27366 Da
Subunit: Interacts with p53/TP53 and HIPK2. Interacts with PRKCG, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B AND
MAP1LC3C
Subcellular location: Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles
between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on
autophagy activation
Secondary accessions: B2RCE5 Q969R9
Alternative splicing: 2 isoforms:  Q96A56-1   Q96A56-2   

Explore the universe of human proteins at neXtProt for TP53INP1: NX_Q96A56

TP53INP1 Protein expression data from MOPED and PaxDb:    About this image 
TP53INP1 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001129205.1  NP_150601.1  

ENSEMBL proteins: 
 ENSP00000390063   ENSP00000344215   ENSP00000368052  

Human Recombinant Protein Products for TP53INP1: 
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OriGene Protein Over-expression Lysate (see all 2): TP53INP1
OriGene Custom Protein Services for TP53INP1 
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Novus Biologicals TP53INP1 Protein
Novus Biologicals TP53INP1 Lysate
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Uscn Proteins for TP53INP1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA--
GO:0005776autophagic vacuole IDA--
GO:0005829cytosol IDA--
GO:0016605PML body IEA--
GO:0031410cytoplasmic vesicle IEA--

TP53INP1 for ontologies           About GeneDecksing



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Abcam antibodies for TP53INP1 
Uscn Antibodies for TP53INP1
ThermoFisher Antibodies for TP53INP1

Assay Products for TP53INP1: 
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GenScript Custom Assay Services for TP53INP1
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Uscn ELISAs and CLIAs for TP53INP1

Protein Domains /
Families
for TP53INP1 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q96A56

UniProtKB/Swiss-Prot: T53I1_HUMAN, Q96A56
Domain: The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A,
MAP1LC3B and MAP1LC3C


Function
for TP53INP1 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Molecular Function:

     UniProtKB/Swiss-Prot Summary: T53I1_HUMAN, Q96A56
Function: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of
transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation
of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP,
GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven
oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS)
regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and
p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA
breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing
cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of
SPARC
Induction: By adriamycin, gamma irradiation and H(2)O(2), in a p53/TP53-dependent way. At lower levels by UV
irradiation. By TP73

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI--
GO:0016209antioxidant activity ISS--
     
TP53INP1 for ontologies           About GeneDecksing


Phenotypes:
     8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Trp53inp1):
 cellular  digestive/alimentary  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
 immune system  mortality/aging  tumorigenesis 

TP53INP1 for phenotypes           About GeneDecksing

Animal Models:
     Mouse knock-out Trp53inp1tm1Acar for TP53INP1
   inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TP53INP1 

miRNA
Products:    		miRTarBase miRNAs that target TP53INP1:
hsa-mir-155 (MIRT003007), hsa-mir-93 (MIRT000021), hsa-mir-125b (MIRT004996), hsa-mir-130b (MIRT000335)

OriGene 3'-UTR Clone (see all 2): TP53INP1
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TP53INP1
8/144 QIAGEN miScript miRNA Assays for microRNAs that regulate TP53INP1 (see all 144):
hsa-miR-140-5p hsa-miR-106a hsa-miR-502-3p hsa-miR-200b hsa-miR-130b hsa-miR-520b hsa-miR-520c-3p hsa-miR-770-5p
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TP53INP1 (see all 4)
OriGene shRNA RFP: TP53INP1
OriGene siRNA: TP53INP1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TP53INP1
Sirion Biotech Custom design and validation of potent shRNA sequences against TP53INP1 

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for TP53INP1
Sirion Biotech Customized adenovirus for overexpression of TP53INP1 
Sirion Biotech Customized adenovirus for potent knockdown of TP53INP1

Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TP53INP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP53INP1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector (see all 2): TP53INP1 (NM_033285)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TP53INP1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53INP1 

Cell Line
Products:     		GenScript Custom overexpressing Cell Line Services for TP53INP1
Search LifeMap BioReagents cell lines for TP53INP1
Sirion Biotech Customized stable knockdown cell line services for TP53INP1 
Sirion Biotech Customized inducible knockdown cell line services for TP53INP1
Sirion Biotech Customized stable overexpressing cell line services for TP53INP1
Sirion Biotech Customized inducible overexpressing cell line services for TP53INP1

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53INP1


Pathways & Interactions
for TP53INP1 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Direct p53 effectors
Direct p53 effectors1.00
2Selected targets of p53
Selected targets of p531.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TP53INP1
    Selected targets of p53


1 BioSystems Pathway for TP53INP1 
    Direct p53 effectors



TP53INP1 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TP53INP1

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for TP53INP1 (Q96A563 ENSP000003442154) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TP53P046373, ENSP000002693054I2D: score=4 STRING: ENSP00000269305
HIPK2Q9H2X63I2D: score=4 
ELAVL1ENSP000003852694STRING: ENSP00000385269
--ENSP000002635514STRING: ENSP00000263551
About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-dependent IEA--
GO:0006914autophagy IEA--
GO:0006915apoptotic process IEA--
GO:0006917induction of apoptosis IEA--
GO:0006950response to stress TAS--

TP53INP1 for ontologies           About GeneDecksing



Drugs & Compounds
for TP53INP1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TP53INP1
Search CenterWatch for drugs/clinical trials and news about TP53INP1 / T53I1 

Transcripts
for TP53INP1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for TP53INP1 gene (2 alternative transcripts): 
NM_001135733.1  NM_033285.3  

Unigene Cluster for TP53INP1:

Tumor protein p53 inducible nuclear protein 1
Hs.492261  [show with all ESTs]
Unigene Representative Sequence: NM_001135733
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000448464(uc003yhh.3) ENST00000342697(uc003yhg.3) ENST00000378776


miRNA
Products:     		 OriGene 3'-UTR Clone (see all 2): TP53INP1
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TP53INP1
8/144 QIAGEN miScript miRNA Assays for microRNAs that regulate TP53INP1 (see all 144):
hsa-miR-140-5p hsa-miR-106a hsa-miR-502-3p hsa-miR-200b hsa-miR-130b hsa-miR-520b hsa-miR-520c-3p hsa-miR-770-5p
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TP53INP1 (see all 4)
OriGene shRNA RFP: TP53INP1
OriGene siRNA: TP53INP1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TP53INP1
Sirion Biotech Custom design and validation of potent shRNA sequences against TP53INP1 
Clone
Products:     		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TP53INP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP53INP1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector (see all 2): TP53INP1 (NM_033285)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TP53INP1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53INP1 
Primer
Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TP53INP1
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TP53INP1
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TP53INP1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP53INP1

Additional cDNA sequence: 

AB017926.1 AB017927.1 AF409114.1 AF409115.1 AK025792.1 AK123608.1 AK125880.1 AK130074.1 
AK315071.1 AL133074.1 AL833652.1 BC074813.2 BC074868.2 

6 DOTS entries:

DT.455421  DT.97840933  DT.100789612  DT.100789611  DT.86854721  DT.121466912 

24/119 AceView cDNA sequences (see all 119):

T19436 AA458946 AW629665 AI475564 AA448646 BC074868 BC074813 AL600013 
AL049155 CF135942 BU677988 BX477504 CA447596 BI494293 AA748540 AI419377 
BM821454 AW341649 AA487091 CB243373 BE221352 AI359101 AA459589 BE245339 

GeneLoc Exon Structure


Expression
for TP53INP1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TP53INP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCCTTCTTA
TP53INP1 Expression
About this image

TP53INP1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

Stem Cell Differentiation: 1 LifeMap Cell 
NameCategory
Posterior foregut-like cells (A scalable, suspensi...)
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See TP53INP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TP53INP1

SOURCE GeneReport for Unigene cluster: Hs.492261

UniProtKB/Swiss-Prot: T53I1_HUMAN, Q96A56
Tissue specificity: Ubiquitously expressed

    SABiosciences Expression via Pathway-Focused PCR Array including TP53INP1: 
          T Helper Cell Differentiation in human mouse rat

Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP53INP1
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53INP1

Orthologs
for TP53INP1 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of animals.

Orthologs for TP53INP1 gene from 6/15 species (see all 15)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia Trp53inp11 , 5 transformation related protein 53 inducible nuclear more1, 5 87.59(n)1
87.87(a)1		   4 (5.03 cM)5
605991  NM_021897.31  NP_068697.11 
 111564315 
chicken
(Gallus gallus)		 Aves TP53INP11 tumor protein p53 inducible nuclear protein 1 75.14(n)
68.64(a)		   420232  NM_001030946.1  NP_001026117.1 
lizard
(Anolis carolinensis)		 Reptilia TP53INP16
 --
 65(a)
 1 ↔ 1
 4(19364054-19367974)
African clawed frog
(Xenopus laevis)		 Amphibia Xl.34802 Xenopus laevis transcribed sequence with weak similarity more 80.03(n)    BI315277.1 
zebrafish
(Danio rerio)		 Actinopterygii wufb70a092 wufb70a09 78.89(n)   322678  CD594269.1 
fruit fly
(Drosophila melanogaster)		 Insecta DOR6
 --
 18(a)
 1 → many
 3L(4406943-4420648)


ENSEMBL Gene Tree for TP53INP1 (if available)
TreeFam Gene Tree for TP53INP1 (if available) 

Paralogs
for TP53INP1 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TP53INP1 gene
TP53INP22  
1 SIMAP similar gene for TP53INP1 using alignment to 2 protein entries:     T53I1_HUMAN (see all proteins):
TP53INP2

TP53INP1 for paralogs           About GeneDecksing



Genomic Variants
for TP53INP1 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/481 NCBI SNPs in TP53INP1 are shown (see all 481)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 8 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1421082871,2
--95937925(+) ACCACA/GCTCAG 2 -- int10--------
rs24676751,2
C,F,A--95937940(+) TTTTCG/ATATTT 2 -- int18Minor allele frequency- A:0.12NA WA CSA 132
rs1467400051,2
--95938031(+) CCAAAC/TTGCTG 2 -- int10--------
rs1840643071,2
--95938038(+) GCTGGA/GATTAC 2 -- int10--------
rs20139951,2
C,F,A,H--95938057(-) GGCGCG/AGTGGC 2 -- int18Minor allele frequency- A:0.12NA WA CSA 16
rs2001977821,2
--95938127(+) TGGAC-/AAAAAA 2 -- int10--------
rs58933091,2
C--95938130(+) ACAAAC/-AAAAC 2 -- int12Minor allele frequency- -:0.25NA CSA 4
rs169171411,2
F--95938130(+) GACAAC/AAAAAC 2 -- int13Minor allele frequency- A:0.19NA 138
rs1441674781,2
--95938186(+) TAAAAC/GAATCT 2 -- int10--------
rs1889614441,2
--95938250(+) CTCCAA/GGTAGT 2 -- ut310--------

HapMap Linkage Disequilibrium report for TP53INP1 (95938200 - 95961639 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for TP53INP1: --

SABiosciences Cancer Mutation PCR Assays
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Disorders / Diseases
for TP53INP1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
TP53INP1 for disorders           About GeneDecksing

OMIM gene information: 606185    OMIM disorders: --

11 diseases for TP53INP1:    About MalaCards
gastritis    esophageal carcinoma    esophagitis    gastric cancer
pancreatic cancer    prostate cancer    pancreatitis    prostatitis
thyroiditis    carcinoma    anaplastic carcinoma

Human Genome Epidemiology (HuGE) Navigator: TP53INP1 (3 documents)

Export disorders for TP53INP1 gene to outside databases

Publications
for TP53INP1 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TP53INP1 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with TP53INP1)		    Utopia: connect your pdf to the dynamic
world of online information

  1. p53DINP1, a p53-inducible gene, regulate p53-dependent apoptosis. (PubMed id 11511362)1, 2, 3, 9 Okamura S.... Nakamura Y. (2001)
  2. Assignment of tumor protein p53 induced nuclear protein 1 (TP53INP1) gene to human chromosome band 8q22 by in situ hybridization. (PubMed id 12438758)1, 3, 9 Nowak J....Pebusque M.J. (2002)
  3. DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription. (PubMed id 22470510)1, 2 Sancho A.... Zorzano A. (2012)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  6. TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity. (PubMed id 12851404)1, 2 Tomasini R.... Dusetti N.J. (2003)
  7. p53-dependent expression of the stress-induced protein (SIP). (PubMed id 12067065)1, 2 Tomasini R.... Iovanna J.L. (2002)
  8. MiR-17-5p targets TP53INP1 and regulates cell prolifer ation and apoptosis of cervical cancer cells. (PubMed id 22730212)1 Wei Q....Tang H. (2012)
  9. TP53INP1 overexpression in prostate cancer correlates with poor prognostic factors and is predictive of biological cancer relapse. (PubMed id 21538421)1 Giusiano S....Rocchi P. (2012)
  10. TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death. (PubMed id 22421968)2 Seillier M.... Dusetti N.J. (2012)

External Searches for TP53INP1 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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Genome Databases showing TP53INP1 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 94241 HGNC: 18022 AceView: TP53INP1 Ensembl:ENSG00000164938 euGenes: HUgn94241
ECgene: TP53INP1 H-InvDB: TP53INP1

Other Databases showing TP53INP1 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing TP53INP1 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TP53INP1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TP53INP1 Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property
for TP53INP1 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TP53INP1 gene:
Search GeneIP for patents involving TP53INP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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