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Aliases for TP53INP1 Gene

Aliases for TP53INP1 Gene

  • Tumor Protein P53 Inducible Nuclear Protein 1 2 3
  • P53DINP1 3 4 6
  • P53-Dependent Damage-Inducible Nuclear Protein 1 3 4
  • Stress-Induced Protein 3 4
  • TP53DINP1 3 6
  • SIP 3 4
  • Tumor Protein P53-Inducible Nuclear Protein 1 3
  • P53-Inducible P53DINP1 3
  • TP53INP1A 3
  • TP53INP1B 3
  • Teap 3

External Ids for TP53INP1 Gene

Summaries for TP53INP1 Gene

GeneCards Summary for TP53INP1 Gene

TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1) is a Protein Coding gene. Among its related pathways are Direct p53 effectors and HTLV-I infection. GO annotations related to this gene include antioxidant activity. An important paralog of this gene is TP53INP2.

UniProtKB/Swiss-Prot for TP53INP1 Gene

  • Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on Ser-46 and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.

Gene Wiki entry for TP53INP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP53INP1 Gene

Genomics for TP53INP1 Gene

Genomic Location for TP53INP1 Gene

Start:
94,925,972 bp from pter
End:
94,949,411 bp from pter
Size:
23,440 bases
Orientation:
Minus strand

Genomic View for TP53INP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TP53INP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53INP1 Gene

Regulatory Elements for TP53INP1 Gene

Proteins for TP53INP1 Gene

  • Protein details for TP53INP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A56-T53I1_HUMAN
    Recommended name:
    Tumor protein p53-inducible nuclear protein 1
    Protein Accession:
    Q96A56
    Secondary Accessions:
    • B2RCE5
    • Q969R9

    Protein attributes for TP53INP1 Gene

    Size:
    240 amino acids
    Molecular mass:
    27366 Da
    Quaternary structure:
    • Interacts with p53/TP53 and HIPK2. Interacts with PRKCG, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B AND MAP1LC3C.

    Alternative splice isoforms for TP53INP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TP53INP1 Gene

Proteomics data for TP53INP1 Gene at MOPED

Post-translational modifications for TP53INP1 Gene

No Post-translational modifications

Other Protein References for TP53INP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TP53INP1 Gene

Domains for TP53INP1 Gene

Protein Domains for TP53INP1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

T53I1_HUMAN
Domain:
  • The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C:
    • Q96A56
genes like me logo Genes that share domains with TP53INP1: view

No data available for Gene Families for TP53INP1 Gene

Function for TP53INP1 Gene

Molecular function for TP53INP1 Gene

UniProtKB/Swiss-Prot Function: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on Ser-46 and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
UniProtKB/Swiss-Prot Induction: By adriamycin, gamma irradiation and H(2)O(2), in a p53/TP53-dependent way. At lower levels by UV irradiation. By TP73.

Gene Ontology (GO) - Molecular Function for TP53INP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22421968
GO:0016209 antioxidant activity ISS --
genes like me logo Genes that share ontologies with TP53INP1: view
genes like me logo Genes that share phenotypes with TP53INP1: view

Animal Models for TP53INP1 Gene

MGI Knock Outs for TP53INP1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TP53INP1 Gene

Localization for TP53INP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP53INP1 Gene

Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TP53INP1 Gene COMPARTMENTS Subcellular localization image for TP53INP1 gene
Compartment Confidence
cytosol 5
nucleus 5
vacuole 5
endoplasmic reticulum 2
extracellular 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TP53INP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22470510
GO:0005776 autophagic vacuole IDA 22421968
GO:0005829 cytosol IDA 22470510
GO:0016605 PML body IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with TP53INP1: view

Pathways for TP53INP1 Gene

genes like me logo Genes that share pathways with TP53INP1: view

Pathways by source for TP53INP1 Gene

1 BioSystems pathway for TP53INP1 Gene
1 KEGG pathway for TP53INP1 Gene

Interacting Proteins for TP53INP1 Gene

Gene Ontology (GO) - Biological Process for TP53INP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006914 autophagy --
GO:0006915 apoptotic process IEA --
GO:0006950 response to stress TAS 22421968
genes like me logo Genes that share ontologies with TP53INP1: view

Transcripts for TP53INP1 Gene

mRNA/cDNA for TP53INP1 Gene

Unigene Clusters for TP53INP1 Gene

Tumor protein p53 inducible nuclear protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TP53INP1 Gene

No ASD Table

Relevant External Links for TP53INP1 Gene

GeneLoc Exon Structure for
TP53INP1
ECgene alternative splicing isoforms for
TP53INP1

Expression for TP53INP1 Gene

mRNA expression in normal human tissues for TP53INP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TP53INP1 Gene

This gene is overexpressed in Liver (5.2) and Pancreas (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TP53INP1 Gene

SOURCE GeneReport for Unigene cluster for TP53INP1 Gene Hs.492261

mRNA Expression by UniProt/SwissProt for TP53INP1 Gene

Q96A56-T53I1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with TP53INP1: view

Orthologs for TP53INP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TP53INP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TP53INP1 36
  • 99.03 (n)
  • 99.17 (a)
TP53INP1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TP53INP1 36
  • 90.83 (n)
  • 90.83 (a)
TP53INP1 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TP53INP1 36
  • 89.96 (n)
  • 88.28 (a)
TP53INP1 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trp53inp1 36
  • 87.59 (n)
  • 87.87 (a)
Trp53inp1 16
Trp53inp1 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TP53INP1 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TP53INP1 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tp53inp1 36
  • 86.75 (n)
  • 86.19 (a)
chicken
(Gallus gallus)
Aves TP53INP1 36
  • 74.44 (n)
  • 68.64 (a)
TP53INP1 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TP53INP1 37
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3480 36
tropical clawed frog
(Silurana tropicalis)
Amphibia tp53inp1 36
  • 61.68 (n)
  • 53.42 (a)
zebrafish
(Danio rerio)
Actinopterygii tp53inp1 36
  • 58.44 (n)
  • 53.25 (a)
tp53inp1 37
  • 45 (a)
OneToOne
wufb70a09 36
fruit fly
(Drosophila melanogaster)
Insecta DOR 37
  • 14 (a)
OneToMany
Species with no ortholog for TP53INP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TP53INP1 Gene

ENSEMBL:
Gene Tree for TP53INP1 (if available)
TreeFam:
Gene Tree for TP53INP1 (if available)

Paralogs for TP53INP1 Gene

Paralogs for TP53INP1 Gene

Selected SIMAP similar genes for TP53INP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TP53INP1: view

Variants for TP53INP1 Gene

Sequence variations from dbSNP and Humsavar for TP53INP1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs7760 -- 94,926,194(-) GCCAC(G/T)GTCTA utr-variant-3-prime
rs896849 -- 94,930,016(-) TTTTA(C/T)ACACT utr-variant-3-prime
rs896850 -- 94,938,175(-) caaaa(C/G)cagaa intron-variant
rs896851 -- 94,938,023(-) ctttt(A/G)tcttc intron-variant
rs1011795 -- 94,938,845(+) gggtc(A/G)tggga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TP53INP1 Gene

Variant ID Type Subtype PubMed ID
dgv7835n71 CNV Loss 21882294
nsv508520 CNV Loss 20534489

Relevant External Links for TP53INP1 Gene

HapMap Linkage Disequilibrium report
TP53INP1

Disorders for TP53INP1 Gene

Relevant External Links for TP53INP1

Genetic Association Database (GAD)
TP53INP1
Human Genome Epidemiology (HuGE) Navigator
TP53INP1
genes like me logo Genes that share disorders with TP53INP1: view

No data available for UniProtKB/Swiss-Prot for TP53INP1 Gene

Publications for TP53INP1 Gene

  1. p53DINP1, a p53-inducible gene, regulate p53-dependent apoptosis. (PMID: 11511362) Okamura S. … Nakamura Y. (Mol. Cell 2001) 2 3 4 23
  2. Assignment of tumor protein p53 induced nuclear protein 1 (TP53INP1) gene to human chromosome band 8q22 by in situ hybridization. (PMID: 12438758) Nowak J. … PAcbusque M.J. (Cytogenet. Genome Res. 2002) 2 3 23
  3. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (PMID: 20581827) Voight B.F. … . (Nat. Genet. 2010) 3 49
  4. TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity. (PMID: 12851404) Tomasini R. … Dusetti N.J. (J. Biol. Chem. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for TP53INP1 Gene

Sources for TP53INP1 Gene

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