Aliases for TP53INP1 Gene
External Ids for TP53INP1 Gene
Previous GeneCards Identifiers for TP53INP1 Gene
GeneCards Summary for TP53INP1 Gene
TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1) is a Protein Coding gene. Among its related pathways are HTLV-I infection and p53 Pathway (RnD). GO annotations related to this gene include antioxidant activity. An important paralog of this gene is TP53INP2.
UniProtKB/Swiss-Prot for TP53INP1 Gene
Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on Ser-46 and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.