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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TP53INP1 Gene

protein-coding   GIFtS: 56
GCID: GC08M095938

Tumor Protein P53 Inducible Nuclear Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Protein P53 Inducible Nuclear Protein 11 2     P53DINP13 5
Stress-Induced Protein2 3     TP53INP1A2
SIP2 3     TP53INP1B2
P53-Dependent Damage-Inducible Nuclear Protein 12 3     Teap2
p53DINP12 3     P53-Inducible P53DINP12
TP53DINP12 5     Tumor Protein P53-Inducible Nuclear Protein 12

External Ids:    HGNC: 180221   Entrez Gene: 942412   Ensembl: ENSG000001649387   OMIM: 6061855   UniProtKB: Q96A563   

Export aliases for TP53INP1 gene to outside databases

Previous GC identifers: GC08M094561 GC08M095909 GC08M095606 GC08M095894 GC08M096007 GC08M091146


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TP53INP1 Gene: 
TP53INP1 (tumor protein p53 inducible nuclear protein 1) is a protein-coding gene. Diseases associated with TP53INP1 include gastritis, and esophagitis. GO annotations related to this gene include protein binding and antioxidant activity. An important paralog of this gene is TP53INP2.

UniProtKB/Swiss-Prot: T53I1_HUMAN, Q96A56
Function: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual
regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular
stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated
proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major
role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive
oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively
regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In
response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis.
Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce
cell migration by regulating the expression of SPARC

Gene Wiki entry for TP53INP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TP53INP1 gene promoter:
         C/EBPbeta   USF1   AML1a   p53   USF2   USF-1:USF-2   Nkx2-5   AREB6   GATA-6   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): TP53INP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TP53INP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP53INP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q22

TP53INP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP53INP1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M095938:  view genomic region     (about GC identifiers)

Start:
95,938,200 bp from pter      End:
95,961,639 bp from pter
Size:
23,440 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T53I1_HUMAN, Q96A56 (See protein sequence)
Recommended Name: Tumor protein p53-inducible nuclear protein 1  
Size: 240 amino acids; 27366 Da
Subunit: Interacts with p53/TP53 and HIPK2. Interacts with PRKCG, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A,
MAP1LC3B AND MAP1LC3C
Subcellular location: Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome.
Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to
autophagosomes on autophagy activation
Secondary accessions: B2RCE5 Q969R9
Alternative splicing: 2 isoforms:  Q96A56-1   Q96A56-2   

Explore the universe of human proteins at neXtProt for TP53INP1: NX_Q96A56

TP53INP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins (2 alternative transcripts): 
NP_001129205.1  NP_150601.1  

ENSEMBL proteins: 
 ENSP00000390063   ENSP00000344215   ENSP00000368052  

Human Recombinant Protein Products for TP53INP1: 
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Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA--
GO:0005776autophagic vacuole IDA--
GO:0005829cytosol IDA--
GO:0016605PML body IEA--
GO:0031410cytoplasmic vesicle IEA--

TP53INP1 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q96A56

UniProtKB/Swiss-Prot: T53I1_HUMAN, Q96A56
Domain: The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A,
MAP1LC3B and MAP1LC3C


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: T53I1_HUMAN, Q96A56
Function: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual
regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular
stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated
proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major
role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive
oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively
regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In
response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis.
Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce
cell migration by regulating the expression of SPARC
Induction: By adriamycin, gamma irradiation and H(2)O(2), in a p53/TP53-dependent way. At lower levels by UV
irradiation. By TP73

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI--
GO:0016209antioxidant activity ISS--
     
TP53INP1 for ontologies           About GeneDecksing


Phenotypes:
     8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Trp53inp1):
 cellular  digestive/alimentary  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
 immune system  mortality/aging  tumorigenesis 

TP53INP1 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Trp53inp1tm1Acar for TP53INP1

   inGenious Targeting Laboratory - Custom generated mouse model solutions for TP53INP1 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TP53INP1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TP53INP1 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TP53INP1 

miRNA
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miRTarBase miRNAs that target TP53INP1:
hsa-mir-155 (MIRT003007), hsa-mir-93 (MIRT000021), hsa-mir-125b (MIRT004996), hsa-mir-130b (MIRT000335)

QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TP53INP1
8/144 QIAGEN miScript miRNA Assays for microRNAs that regulate TP53INP1 (see all 144):
hsa-miR-140-5p hsa-miR-106a hsa-miR-502-3p hsa-miR-200b hsa-miR-130b hsa-miR-520b hsa-miR-520c-3p hsa-miR-770-5p
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53INP1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TP53INP1 About                                                                                                See pathways by source

SuperPathContained pathways About
1Selected targets of p53
Selected targets of p53
2Direct p53 effectors
Direct p53 effectors
3HTLV-I infection
HTLV-I infection

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for TP53INP1
    Selected targets of p53


1 BioSystems Pathway for TP53INP1
    Direct p53 effectors


1         Kegg Pathway  (Kegg details for TP53INP1):
    HTLV-I infection


TP53INP1 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TP53INP1

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for TP53INP1 (Q96A563 ENSP000003442154) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TP53P046373, ENSP000002693054I2D: score=4 STRING: ENSP00000269305
HIPK2Q9H2X63I2D: score=4 
ELAVL1ENSP000003852694STRING: ENSP00000385269
--ENSP000002635514STRING: ENSP00000263551
About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-dependent IEA--
GO:0006914autophagy IEA--
GO:0006915apoptotic process IEA--
GO:0006950response to stress TAS--
GO:0007050cell cycle arrest TAS--

TP53INP1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TP53INP1 (T53I1)

Search CenterWatch for drugs/clinical trials and news about TP53INP1 / T53I1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TP53INP1 gene (2 alternative transcripts): 
NM_001135733.1  NM_033285.3  

Unigene Cluster for TP53INP1:

Tumor protein p53 inducible nuclear protein 1
Hs.492261  [show with all ESTs]
Unigene Representative Sequence: NM_001135733
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000448464(uc003yhh.3) ENST00000342697(uc003yhg.3) ENST00000378776

miRNA
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8/144 QIAGEN miScript miRNA Assays for microRNAs that regulate TP53INP1 (see all 144):
hsa-miR-140-5p hsa-miR-106a hsa-miR-502-3p hsa-miR-200b hsa-miR-130b hsa-miR-520b hsa-miR-520c-3p hsa-miR-770-5p
Browse SwitchGear 3'UTR luciferase reporter plasmids
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Sirion Biotech Customized lentivirus for stable overexpression of TP53INP1 
                     Customized lentivirus expression plasmids for stable overexpression of TP53INP1 
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TP53INP1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP53INP1

Additional mRNA sequence: 

AB017926.1 AB017927.1 AF409114.1 AF409115.1 AK025792.1 AK123608.1 AK125880.1 AK130074.1 
AK315071.1 AL133074.1 AL833652.1 BC074813.2 BC074868.2 

6 DOTS entries:

DT.455421  DT.97840933  DT.100789612  DT.100789611  DT.86854721  DT.121466912 

24/119 AceView cDNA sequences (see all 119):

AA448646 BC074813 BC074868 T19436 AI475564 AA458946 AW629665 AA748540 
BM991645 BX498400 AW341649 AA459589 BM720903 CB162273 AI359101 AF409115 
AL833652 CB266444 AW151796 BP342425 AA487091 BU685913 AK125880 AL133074 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TP53INP1 expression in normal human tissues (normalized intensities)      TP53INP1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGCCTTCTTA
TP53INP1 Expression
About this image


TP53INP1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/16 selected tissues (see all 16) fully expand
 
 Brain (Nervous System)    fully expand to see all 8 entries
         Thalamus
         brain/midbrain   
 
 Neural Tube (Nervous System)    fully expand to see all 3 entries
         Metencephalon
 
 Nose (Sensory Organs)    fully expand to see all 2 entries
         sensory organ/nose/nasal cavity   
 
 Gut Tube (Gastrointestinal Tract)
         Foregut
 
 Mesoderm (Gastrulation Derivatives)
         skeleton/axial skeleton   

Genevestigator expression for TP53INP1

SOURCE GeneReport for Unigene cluster: Hs.492261

UniProtKB/Swiss-Prot: T53I1_HUMAN, Q96A56
Tissue specificity: Ubiquitously expressed

    SABiosciences Expression via Pathway-Focused PCR Array including TP53INP1: 
          T Helper Cell Differentiation in human mouse rat

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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP53INP1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53INP1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TP53INP1 gene from 6/12 species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Trp53inp11 , 5 transformation related protein 53 inducible nuclear more1, 5 87.59(n)1
87.87(a)1
  4 (5.03 cM)5
605991  NM_021897.31  NP_068697.11 
 111564315 
chicken
(Gallus gallus)
Aves TP53INP11 tumor protein p53 inducible nuclear protein 1 75.14(n)
68.64(a)
  420232  NM_001030946.1  NP_001026117.1 
lizard
(Anolis carolinensis)
Reptilia TP53INP16
tumor protein p53 inducible nuclear protein 1
63(a)
1 ↔ 1
4(19359910-19376068)
African clawed frog
(Xenopus laevis)
Amphibia Xl.34802 Xenopus laevis transcribed sequence with weak similarity more 80.03(n)    BI315277.1 
zebrafish
(Danio rerio)
Actinopterygii wufb70a092 wufb70a09 78.89(n)   322678  CD594269.1 
fruit fly
(Drosophila melanogaster)
Insecta DOR6
--
13(a)
1 → many
3L(4406943-4420648)


ENSEMBL Gene Tree for TP53INP1 (if available)
TreeFam Gene Tree for TP53INP1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TP53INP1 gene
TP53INP22  
1 SIMAP similar gene for TP53INP1 using alignment to 2 protein entries:     T53I1_HUMAN (see all proteins):
TP53INP2

TP53INP1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/555 SNPs in TP53INP1 are shown (see all 555)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1421082871,2
--95937925(+) ACCACA/GCTCAG 2 -- int10--------
rs24676751,2
C,F,A--95937940(+) TTTTCG/ATATTT 2 -- int110Minor allele frequency- A:0.11NA WA CSA 136
rs1467400051,2
C--95938031(+) CCAAAC/TTGCTG 2 -- int10--------
rs1840643071,2
--95938038(+) GCTGGA/GATTAC 2 -- int10--------
rs20139951,2
C,F,A,H--95938057(-) GGCGCG/AGTGGC 2 -- int18Minor allele frequency- A:0.12NA WA CSA 16
rs2001977821,2
--95938127(+) TGGAC-/AAAAAA 2 -- int10--------
rs169171411,2
F--95938130(+) GACAAC/AAAAAC 2 -- int13Minor allele frequency- A:0.19NA 138
rs339743621,2
C--95938131(+) CAAAA-/CAAACT 2 -- int10--------
rs1441674781,2
C--95938186(+) TAAAAC/GAATCT 2 -- int10--------
rs1889614441,2
--95938250(+) CTCCAA/GGTAGT 2 -- ut310--------

HapMap Linkage Disequilibrium report for TP53INP1 (95938200 - 95961639 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for TP53INP1:    About this table     
Variant IDTypeSubtypePubMed ID
dgv7835n71CNV Loss21882294
nsv508520CNV Loss20534489

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606185    OMIM disorders: --

10 diseases for TP53INP1:    About MalaCards
gastritis    esophagitis    pancreatic cancer    gastric cancer
cervical cancer    pancreatitis    prostate cancer    thyroiditis
cervicitis    prostatitis


TP53INP1 for disorders           About GeneDecksing

Genetic Association Database (GAD): TP53INP1
Human Genome Epidemiology (HuGE) Navigator: TP53INP1 (3 documents)

Export disorders for TP53INP1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TP53INP1 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with TP53INP1)
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  1. p53DINP1, a p53-inducible gene, regulate p53-dependent apoptosis. (PubMed id 11511362)1, 2, 3, 9 Okamura S.... Nakamura Y. (2001)
  2. Assignment of tumor protein p53 induced nuclear protein 1 (TP53INP1) gene to human chromosome band 8q22 by in situ hybridization. (PubMed id 12438758)1, 3, 9 Nowak J....Pebusque M.J. (2002)
  3. TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death. (PubMed id 22421968)1, 2 Seillier M.... Dusetti N.J. (2012)
  4. DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription. (PubMed id 22470510)1, 2 Sancho A.... Zorzano A. (2012)
  5. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (PubMed id 20581827)1, 4 Voight B.F.... . (2010)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  8. TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity. (PubMed id 12851404)1, 2 Tomasini R.... Dusetti N.J. (2003)
  9. p53-dependent expression of the stress-induced protein (SIP). (PubMed id 12067065)1, 2 Tomasini R.... Iovanna J.L. (2002)
  10. miR-17-5p/20a are important markers for gastric cancer and murine double minute 2 participates in their functional regulation. (PubMed id 23333058)1 Wang M....Xu W. (2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 94241 HGNC: 18022 AceView: TP53INP1 Ensembl:ENSG00000164938 euGenes: HUgn94241
ECgene: TP53INP1 Kegg: 94241 H-InvDB: TP53INP1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TP53INP1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TP53INP1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TP53INP1 gene:
Search GeneIP for patents involving TP53INP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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