Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TP53I3 Gene

protein-coding   GIFtS: 66
GCID: GC02M024300

Tumor Protein P53 Inducible Protein 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Tumor Protein P53 Inducible Protein 31 2     Quinone Oxidoreductase PIG32
PIG32 3 5     EC 1.-.-.-3
P53-Induced Gene 3 Protein2 3     Tumor Protein P53-Inducible Protein 33
Quinone Oxidoreductase Homolog2     

External Ids:    HGNC: 193731   Entrez Gene: 95402   Ensembl: ENSG000001151297   OMIM: 6051715   UniProtKB: Q53FA73   

Export aliases for TP53I3 gene to outside databases

Previous GC identifers: GC02M024392 GC02M024258 GC02M024274 GC02M024211 GC02M024153 GC02M024039


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TP53I3 Gene:
The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses
to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be
involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a
downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by
interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with
a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by
p53. It has been suggested that the microsatellite polymorphism may be associated with differential
susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, May 2011)

GeneCards Summary for TP53I3 Gene:
TP53I3 (tumor protein p53 inducible protein 3) is a protein-coding gene. Diseases associated with TP53I3 include constrictive pericarditis, and pericarditis. GO annotations related to this gene include protein homodimerization activity and NADPH binding. An important paralog of this gene is VAT1.

UniProtKB/Swiss-Prot: QORX_HUMAN, Q53FA7
Function: May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent
beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over
1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro)

Gene Wiki entry for TP53I3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TP53I3 gene promoter:
         POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TP53I3 promoter sequence
   Search Chromatin IP Primers for TP53I3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TP53I3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

TP53I3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP53I3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M024300:  view genomic region     (about GC identifiers)

Start:
24,300,303 bp from pter      End:
24,308,731 bp from pter
Size:
8,429 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: QORX_HUMAN, Q53FA7 (See protein sequence)
Recommended Name: Quinone oxidoreductase PIG3  
Size: 332 amino acids; 35536 Da
Subunit: Homodimer
Sequence caution: Sequence=AAC39535.1; Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for TP53I3:
2J8Z (3D)        2OBY (3D)    
Secondary accessions: D6W533 O14679 O14685 Q38G78 Q6JLE7 Q9BWB8
Alternative splicing: 2 isoforms:  Q53FA7-1   Q53FA7-2   (Major isoform under UV light exposure. Undergoes rapid proteolytic degradation by the proteasome)

Explore the universe of human proteins at neXtProt for TP53I3: NX_Q53FA7

Explore proteomics data for TP53I3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TP53I3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001193731.1  NP_004872.2  NP_671713.1  

    ENSEMBL proteins: 
     ENSP00000337834   ENSP00000238721   ENSP00000384414   ENSP00000389620   ENSP00000322298  

    TP53I3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for TP53I3
    OriGene Protein Over-expression Lysate for TP53I3
    OriGene MassSpec for TP53I3
    OriGene Custom Protein Services for TP53I3
    GenScript Custom Purified and Recombinant Proteins Services for TP53I3
    Novus Biologicals TP53I3 Proteins
    Novus Biologicals TP53I3 Lysates
    Sino Biological Recombinant Protein for TP53I3
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TP53I3
    Cloud-Clone Corp. Proteins for TP53I3

    TP53I3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TP53I3
    OriGene Custom Antibody Services for TP53I3
    Novus Biologicals TP53I3 Antibodies
    Abcam antibodies for TP53I3
    Cloud-Clone Corp. Antibodies for TP53I3
    ThermoFisher Antibody for TP53I3
    LSBio Antibodies in human, mouse, rat for TP53I3

    TP53I3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TP53I3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TP53I3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TP53I3
    Cloud-Clone Corp. CLIAs for TP53I3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 6):
     IPR014189 Quinone_OxRdtase_PIG3
     IPR013149 ADH_C
     IPR011032 GroES-like
     IPR016040 NAD(P)-bd_dom
     IPR013154 ADH_GroES-like

    Graphical View of Domain Structure for InterPro Entry Q53FA7

    ProtoNet protein and cluster: Q53FA7

    2 Blocks protein domains:
    IPB002364 Quinone oxidoreductase/zeta-crystallin
    IPB013154 Alcohol dehydrogenase GroES-like


    UniProtKB/Swiss-Prot: QORX_HUMAN, Q53FA7
    Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily


    TP53I3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: QORX_HUMAN, Q53FA7
    Function: May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent
    beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over
    1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro)
    Biophysicochemical properties: Kinetic parameters: KM=215 uM for 1,2-naphthoquinone;
    Induction: Isoform 1 and isoform 2 are both activated by p53/TP53, doxorubicin, etoposide and ionizing radiation.
    Isoform 2 is highly activated by UV radiation

         Enzyme Number (IUBMB): EC 1.-.-.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003960NADPH:quinone reductase activity IDA19349281
    GO:0008270zinc ion binding IEA--
    GO:0016491oxidoreductase activity ----
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
    GO:0042803protein homodimerization activity IPI19349281
         
    TP53I3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TP53I3:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TP53I3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TP53I3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TP53I3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TP53I3

    miRNA
    Products:
        
    miRTarBase miRNAs that target TP53I3:
    hsa-mir-504-5p (MIRT016254), hsa-mir-26b-5p (MIRT029187)

    Block miRNA regulation of human, mouse, rat TP53I3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TP53I3
    SwitchGear 3'UTR luciferase reporter plasmidTP53I3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TP53I3
    Predesigned siRNA for gene silencing in human, mouse, rat TP53I3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TP53I3

    Clone
    Products:
         
    OriGene clones in human, mouse for TP53I3 (see all 11)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TP53I3 (NM_004881)
    Sino Biological Human cDNA Clone for TP53I3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TP53I3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53I3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TP53I3
    Browse ESI BIO Cell Lines and PureStem Progenitors for TP53I3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53I3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    TP53I3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TP53I3 About    
    See pathways by source

    SuperPathContained pathways About
    1p53 signaling pathway
    p53 signaling pathway0.41
    2Selected targets of p53
    Selected targets of p53
    3Direct p53 effectors
    Direct p53 effectors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TP53I3
        Direct p53 effectors



    1 Kegg Pathway  (Kegg details for TP53I3):
        p53 signaling pathway


    TP53I3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including TP53I3: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TP53I3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for TP53I3 (Q53FA73 ENSP000002387214) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FUNDC2Q9BWH23, ENSP000003585104I2D: score=4 STRING: ENSP00000358510
    H2AFXP161043, ENSP000003643104I2D: score=1 STRING: ENSP00000364310
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    TP53BP1Q128883, ENSP000003714754I2D: score=1 STRING: ENSP00000371475
    CSE1LP550603, ENSP000002629824I2D: score=1 STRING: ENSP00000262982
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006739NADP metabolic process IDA19349281
    GO:0008631intrinsic apoptotic signaling pathway in response to oxidative stress ----
    GO:0055114oxidation-reduction process ----

    TP53I3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for TP53I3 (see all 15)     About this table
    CompoundAction CAS #
    AMG232potent and selective piperidinone inhibitor of the MDM2-p53 interaction--
    CP 31398 dihydrochloridep53 stabilizing agent. [1217195-61-3]
    JNJ-26854165 (Serdemetan)p53 activator, blocking Mdm2-p53 interaction[881202-45-5]
    Nutlin-3inhibitor of the MDM2/p53 interaction[890090-75-2]
    Nutlin-3a chiralinhibits the MDM2-p53 interaction and activates p53. [675576-98-4]
    p53 and MDM2 proteins-interaction-inhibitor chiralinhibitor of the interaction between p53 and MDM2 proteins[939981-37-0]
    Pifithrin-miuInhibits p53 binding to mitochondria[64984-31-2]
    PRIMA-1Cell-permeable BAX inhibitor, restore p53 activity[5608-24-2]
    PRIMA-1METCell-permeable BAX inhibitor, restore p53 activity[5291-32-7]
    RG7112Restoration of p53 activity by inhibiting the p53-MDM2 interaction[939981-39-2]

    Browse Tocris compounds for TP53I3 (QORX)

    7 HMDB Compounds for TP53I3    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Isobutanol1-Hydroxymethylpropane (see all 18)78-83-1--
    Isopropyl alcohol2-Propanol (see all 12)67-63-0--
    Propyl alcohol1-Hydroxypropane (see all 17)71-23-8--

    2 Novoseek inferred chemical compound relationships for TP53I3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    quinone 53.8 6 19349281 (2), 16276348 (1), 11322664 (1)
    oxygen 0.348 2 19349281 (2)



    TP53I3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TP53I3 gene (3 alternative transcripts): 
    NM_001206802.2  NM_004881.4  NM_147184.3  

    Unigene Cluster for TP53I3:

    Tumor protein p53 inducible protein 3
    Hs.50649  [show with all ESTs]
    Unigene Representative Sequence: NM_004881
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335934(uc002rex.2 uc002rey.2) ENST00000238721(uc002rez.2 uc010ykk.2)
    ENST00000407482 ENST00000417886 ENST00000413037 ENST00000470636 ENST00000313482

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TP53I3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TP53I3
    SwitchGear 3'UTR luciferase reporter plasmidTP53I3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TP53I3
    Predesigned siRNA for gene silencing in human, mouse, rat TP53I3
    Clone
    Products:
         
    OriGene clones in human, mouse for TP53I3 (see all 11)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TP53I3 (NM_004881)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TP53I3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53I3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TP53I3
    OriGene qSTAR qPCR primer pairs in human, mouse for TP53I3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TP53I3
      QuantiTect SYBR Green Assays in human, mouse, rat TP53I3
      QuantiFast Probe-based Assays in human, mouse, rat TP53I3

    Additional mRNA sequence: 

    AF010309.1 AK223382.1 AK297579.1 AY371700.1 BC000474.2 BC018819.2 BT007149.1 

    12 DOTS entries:

    DT.440902  DT.91690543  DT.100811109  DT.100811112  DT.100811113  DT.100836719  DT.120954470  DT.100034658 
    DT.100034145  DT.100706550  DT.100765745  DT.95075022 

    Selected AceView cDNA sequences (see all 141):

    NM_147184 CD365166 CB850754 CB529543 BU737915 BX358124 BC000474 AA583462 
    BI113937 AI349576 BQ773610 BI759631 CD365110 BM710974 CA443934 AY371700 
    AI143067 AW444818 BI827100 CR619579 CR605377 BI831143 CD365836 BC018819 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TP53I3 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b
    SP1:                    -                                   -                                 
    SP2:                    -                       -     -     -                                 
    SP3:                    -                       -                                             
    SP4:                                      -                 -                                 
    SP5:                                                        -     -     -     -               


    ECgene alternative splicing isoforms for TP53I3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TP53I3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGCCAACA
    TP53I3 Expression
    About this image


    TP53I3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Esophagus (Gastrointestinal Tract)
    TP53I3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TP53I3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.50649
        Pathway & Disease-focused RT2 Profiler PCR Array including TP53I3: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TP53I3
    OriGene qSTAR qPCR primer pairs in human, mouse for TP53I3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TP53I3
    QuantiTect SYBR Green Assays in human, mouse, rat TP53I3
    QuantiFast Probe-based Assays in human, mouse, rat TP53I3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53I3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TP53I3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TP53I31 tumor protein p53 inducible protein 3 66.67(n)
    68.88(a)
      421977  XM_004935793.1  XP_004935850.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    22(a)
    many ↔ many
    GL343300.1(172621-201806)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tp53i31 tumor protein p53 inducible protein 3 66.67(n)
    68.37(a)
      779670  NM_001078755.1  NP_001072223.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7964731 quinone oxidoreductase PIG3-like 59.79(n)
    58.41(a)
      796473  XM_001336780.3  XP_001336816.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ZTA1(YBR046C)4 NADPH-dependent quinone reductase, GFP-tagged protein more   --   2(331511-330507) 852335  NP_009602.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G215801 AT4G21580 49.18(n)
    43.52(a)
      828243  NM_118278.2  NP_193889.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g08056001 Os02g0805600 51.14(n)
    43.48(a)
      4331066  NM_001054977.1  NP_001048442.1 
            Species with no ortholog for TP53I3

    ENSEMBL Gene Tree for TP53I3 (if available)
    TreeFam Gene Tree for TP53I3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TP53I3 gene
    VAT12  ZADH22  VAT1L2  CRYZ2  
    3 SIMAP similar genes for TP53I3 using alignment to 3 protein entries:     QORX_HUMAN (see all proteins):
    CRYZ    VAT1L    CRYZL1

    TP53I3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TP53I3 (see all 230)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0330324
    A breast cancer sample4--see VAR_0330322 M K mis40--------
    rs1884398011,2
    --24219036(+) GGTGGA/GGCCCA 3 -- ds50010--------
    rs41493731,2
    C,F--24219051(-) TGCCCG/ACTACT 3 -- ds50019Minor allele frequency- A:0.14NS CSA WA NA EA 487
    rs102064491,2
    C,F--24219260(+) CAGTAA/GTCCCC 3 -- ds50018Minor allele frequency- G:0.12NS NA 258
    rs1127781901,2
    F--24219271(+) GCTGCG/CACGCC 3 -- ds50011Minor allele frequency- C:0.50CSA 2
    rs1498903871,2
    C--24219452(+) TGGCCA/GCGTCC 3 -- ut310--------
    rs2018652161,2
    C--24219545(+) CTCCTC/GGATTT 6 Q E P R mis10--------
    rs102092381,2
    C,F,A,H--24219591(+) AGACGT/CTGGGG 6 /Q /T /A syn1 mis1 ese330Minor allele frequency- C:0.10NS EA MN NA WA CSA EU 8622
    rs1449362761,2
    C--24219597(+) TGGGGG/ACCCTC 6 /G /P /S syn1 mis11Minor allele frequency- A:0.00NA 4552
    rs2003304651,2
    C--24219667(+) AAGACA/GAGGGA 3 -- int11Minor allele frequency- G:0.00EU 1323

    HapMap Linkage Disequilibrium report for TP53I3 (24300303 - 24308731 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TP53I3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2641CNV Loss18451855
    dgv4070n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): TP53I3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TP53I3
    DNA2.0 Custom Variant and Variant Library Synthesis for TP53I3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605171    OMIM disorders: --

    16 diseases for TP53I3:    
    About MalaCards
    constrictive pericarditis    pericarditis    lung cancer susceptibility    hodgkin's lymphoma
    non-hodgkin lymphoma    malignant glioma    squamous cell carcinoma of the head and neck    esophagitis
    sarcoma    lung cancer    tuberculosis    ovarian cancer
    adenocarcinoma    endotheliitis    squamous cell carcinoma    leukemia


    TP53I3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TP53I3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ewings sarcoma 48.2 3 15192123 (3)
    tumors 21.8 5 20510196 (2), 11919562 (1), 17334636 (1), 15067011 (1)

    Genetic Association Database (GAD): TP53I3
    Human Genome Epidemiology (HuGE) Navigator: TP53I3 (11 documents)

    Export disorders for TP53I3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TP53I3 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with TP53I3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3. (PubMed id 19349281)1, 2, 3, 9 Porte S....Pares X. (J. Biol. Chem. 2009)
    2. UV-dependent alternative splicing uncouples p53 activity and PIG3 gene function through rapid proteolytic degradation. (PubMed id 15067011)1, 2, 9 Nicholls C.D.... Beattie T.L. (J. Biol. Chem. 2004)
    3. p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest. (PubMed id 10840161)1, 3, 9 Flatt P.M....Pietenpol J.A. (Cancer Lett. 2000)
    4. A polymorphic microsatellite that mediates induction of PIG3 by p53. (PubMed id 11919562)1, 3, 9 Contente A....Dobbelstein M. (Nat. Genet. 2002)
    5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    6. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    7. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    8. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
    9. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    10. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9540 HGNC: 19373 AceView: TP53I3 Ensembl:ENSG00000115129 euGenes: HUgn9540
    ECgene: TP53I3 Kegg: 9540 H-InvDB: TP53I3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TP53I3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TP53I3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tp53i3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TP53I3 gene:
    Search GeneIP for patents involving TP53I3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TP53I3   OriGene RNAi products in human, mouse, rat for TP53I3  
     OriGene qPCR primer pairs and template standards for TP53I3   OriGene Protein Over-expression Lysate for TP53I3  
     OriGene MassSpec something-or-other for TP53I3   OriGene clones in human, mouse for TP53I3  
     OriGene qSTAR qPCR primer pairs in human, mouse for TP53I3   OriGene Purified Protein for TP53I3  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TP53I3   OriGene Custom Protein Services for TP53I3  

     
     
     Block miRNA regulation of human, mouse, rat TP53I3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TP53I3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TP53I3 Predesigned siRNA for gene silencing in human, mouse, rat TP53I3
     QuantiFast Probe-based Assays in human, mouse, rat TP53I3 QuantiTect SYBR Green Assays in human, mouse, rat TP53I3
     PCR Arrays including human, mouse, rat TP53I3 Search Chromatin IP Primers for TP53I3
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TP53I3  GeneGlobe Interaction Network for TP53I3
     Regulatory tfbs in TP53I3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TP53I3 GenScript cDNA clones with any tag delivered in your preferred vector for TP53I3
     GenScript Custom Assay Services for TP53I3 GenScript Custom overexpressing Cell Line Services for TP53I3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TP53I3 (QORX)
     Proteins for TP53I3
     Browse Sino Biological Cell Lysates
     cDNA Clones for TP53I3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TP53I3 antibodies
     TP53I3 proteins
     TP53I3 lysates
     Antibodies for TP53I3
     See all of Abcam's Antibodies, Kits and Proteins for TP53I3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TP53I3
     Proteins for TP53I3
     Antibodies for TP53I3
     ELISAs for TP53I3
     CLIAs for TP53I3



     Browse ESI BIO Cell Lines and PureStem Progenitors for TP53I3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53I3
     SwitchGear 3'UTR luciferase reporter plasmids for TP53I3
     SwitchGear Promoter luciferase reporter plasmids for TP53I3
     ThermoFisher Antibody for TP53I3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53I3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TP53I3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TP53I3
     LSBio Antibodies in human, mouse, rat for TP53I3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     ApexBio compounds for TP53I3
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TP53I3 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4