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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TP53I3 Gene

protein-coding GIFtS: 63
GCID: GC02M024300

tumor protein p53 inducible protein 3

Explore 18 diseases affiliated with
TP53I3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tumor Protein P53 Inducible Protein 3¹ ²		Quinone Oxidoreductase PIG3²
PIG3¹ ² ³ ⁵		EC 1.-.-.-³
P53-Induced Gene 3 Protein² ³		Tumor Protein P53-Inducible Protein 3³
Quinone Oxidoreductase Homolog²

External Ids:	HGNC: 19373¹	Entrez Gene: 9540²	Ensembl: ENSG00000115129⁷	OMIM: 605171⁵	UniProtKB: Q53FA7³

Export aliases for TP53I3 gene to outside databases

Previous GC identifers: GC02M024392 GC02M024258 GC02M024274 GC02M024211 GC02M024153 GC02M024039

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TP53I3:

The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to

oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in

p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream

pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting

with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number

of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been

suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer.

Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by

RefSeq, May 2011)

UniProtKB/Swiss-Prot: QORX_HUMAN, Q53FA7

Function: May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent

beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone.

Has low NADPH-dependent diamine reductase activity (in vitro)

Gene Wiki entry for TP53I3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TP53I3 gene promoter:
POU2F1 POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TP53I3 promoter sequence

Search SABiosciences Chromatin IP Primers for TP53I3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP53I3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p23.3

TP53I3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP53I3 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M024300: view genomic region (about GC identifiers)

Start:	24,300,303 bp from pter	End:	24,308,731 bp from pter
Size:	8,429 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: QORX_HUMAN, Q53FA7 (See protein sequence)

Recommended Name: Quinone oxidoreductase PIG3

Size: 332 amino acids; 35536 Da

Subunit: Homodimer

Sequence caution: Sequence=AAC39535.1; Type=Erroneous gene model prediction;

2 PDB 3D structures from and Proteopedia for TP53I3:

2J8Z (3D)

2OBY (3D)

Secondary accessions: D6W533 O14679 O14685 Q38G78 Q6JLE7 Q9BWB8

Alternative splicing: 2 isoforms: Q53FA7-1 Q53FA7-2 (Major isoform under UV light exposure. Undergoes rapid proteolytic degradation by the proteasome)

Explore the universe of human proteins at neXtProt for TP53I3: NX_Q53FA7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q53FA7

TP53I3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001193731.1 NP_004872.2 NP_671713.1

ENSEMBL proteins:

ENSP00000337834 ENSP00000238721 ENSP00000384414 ENSP00000389620 ENSP00000322298

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	Uscn Proteins for TP53I3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

TP53I3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TP53I3 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR014189 Quinone_OxRdtase_PIG3

IPR013149 ADH_C

IPR011032 GroES-like

IPR016040 NAD(P)-bd_dom

IPR013154 ADH_GroES-like

Graphical View of Domain Structure for InterPro Entry Q53FA7

ProtoNet protein and cluster: Q53FA7

2 Blocks protein families:

IPB002364 Quinone oxidoreductase/zeta-crystallin

IPB013154 Alcohol dehydrogenase GroES-like

UniProtKB/Swiss-Prot: QORX_HUMAN, Q53FA7

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: QORX_HUMAN, Q53FA7

Function: May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent

beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone.

Has low NADPH-dependent diamine reductase activity (in vitro)

Biophysicochemical properties: Kinetic parameters: KM=215 uM for 1,2-naphthoquinone;

Induction: Isoform 1 and isoform 2 are both activated by p53/TP53, doxorubicin, etoposide and ionizing radiation.

Isoform 2 is highly activated by UV radiation

Enzyme Number (IUBMB): EC 1.-.-.-¹

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53I3

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003960	NADPH:quinone reductase activity	IDA	19349281
GO:0008270	zinc ion binding	IEA	--
GO:0016491	oxidoreductase activity	--	--
GO:0042803	protein homodimerization activity	IPI	19349281
GO:0048038	quinone binding	IDA	19349281

TP53I3 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for TP53I3:

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Direct p53 effectors

Direct p53 effectors

1.00

p53 signaling pathway

p53 signaling pathway

1.00

Selected targets of p53

Selected targets of p53

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TP53I3

Selected targets of p53

1 BioSystems Pathway for TP53I3

Direct p53 effectors

1 Kegg Pathway (Kegg details for TP53I3):

p53 signaling pathway

TP53I3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TP53I3

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/24 Interacting proteins for TP53I3 (Q53FA7³ ENSP00000238721⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 24)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FUNDC2	Q9BWH2³, ENSP00000358510⁴	I2D: score=4 STRING: ENSP00000358510
H2AFX	P16104³, ENSP00000364310⁴	I2D: score=1 STRING: ENSP00000364310
TP53	P04637³, ENSP00000269305⁴	I2D: score=1 STRING: ENSP00000269305
TP53BP1	Q12888³, ENSP00000371475⁴	I2D: score=1 STRING: ENSP00000371475
CSE1L	P55060³, ENSP00000262982⁴	I2D: score=1 STRING: ENSP00000262982

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006739	NADP metabolic process	IDA	19349281
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	NAS	--

TP53I3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TP53I3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TP53I3

7 HMDB Compounds for TP53I3 About this table

Compound	Synonyms	CAS #	PubMed Ids
1-Butanol	1-Butanol (see all 10)	71-36-3	--
1-Hexanol	1-Hexyl alcohol (see all 30)	111-27-3	--
1-Pentanol	1-Pentol (see all 34)	71-41-0	--
Ethanol	1-Hydroxyethane (see all 57)	64-17-5	--
Isobutanol	1-Hydroxymethylpropane (see all 18)	78-83-1	--
Isopropyl alcohol	2-Propanol (see all 12)	67-63-0	--
Propyl alcohol	1-Hydroxypropane (see all 17)	71-23-8	--

2 Novoseek chemical compound relationships for TP53I3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
quinone	53.8	6	19349281 (2), 16276348 (1), 11322664 (1)
oxygen	0.348	2	19349281 (2)

Search CenterWatch for drugs/clinical trials and news about TP53I3 / QORX

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TP53I3 gene (3 alternative transcripts):

NM_001206802.2 NM_004881.4 NM_147184.3

Unigene Cluster for TP53I3:

Tumor protein p53 inducible protein 3

Hs.50649 [show with all ESTs]

Unigene Representative Sequence: NM_004881

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000335934(uc002rex.2 uc002rey.2) ENST00000238721(uc002rez.2 uc010ykk.2)

ENST00000407482 ENST00000417886 ENST00000413037 ENST00000470636 ENST00000313482

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Additional cDNA sequence:

AF010309.1 AK223382.1 AK297579.1 AY371700.1 BC000474.2 BC018819.2 BT007149.1

11 DOTS entries:

DT.440902 DT.91690543 DT.100811112 DT.100811109 DT.100811113 DT.100836719 DT.120954470 DT.100034658

DT.100706550 DT.100765745 DT.95075022

24/141 AceView cDNA sequences (see all 141):

BU737915 CB529543 BX358124 BQ070595 CD365110 AA583462 AY371700 CD365166

BU740057 BC000474 AI143067 BC018819 BQ773610 NM_004881 BI113937 BM789845

BI827100 CF528605 CR619579 NM_147184 CR605377 AW444818 BM710974 BI831143

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TP53I3 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	^	6a	·	6b
SP1:							-												-
SP2:							-								-		-		-
SP3:							-								-
SP4:													-						-
SP5:																			-		-		-		-

ECgene alternative splicing isoforms for TP53I3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TP53I3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGCCAACA

About this image

TP53I3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mesendoderm-like cells (Generation of mesend...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TP53I3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TP53I3

SOURCE GeneReport for Unigene cluster: Hs.50649

SABiosciences Expression via Pathway-Focused PCR Array including TP53I3:

Apoptosis 384HT in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for TP53I3 gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TP53I3¹	tumor protein p53 inducible protein 3	66.67(n) 68.88(a)		421977 XM_419987.2 XP_419987.2
lizard (Anolis carolinensis)	Reptilia	--	--	24(a)	1 ↔ 1	GL343300.1(175071-195427)
zebrafish (Danio rerio)	Actinopterygii	LOC796473¹	quinone oxidoreductase PIG3-like	59.94(n) 58.97(a)		796473 XM_001336780.2 XP_001336816.1
honey bee (Apis mellifera)	Insecta	--	--	29(a)	1 ↔ 1	GroupUn.6169(310-858)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G21580¹	putative NADPH quinone oxidoreductase	49.18(n) 43.52(a)		828243 NM_118278.2 NP_193889.1
rice (Oryza sativa)	Liliopsida	Os02g0805600¹	hypothetical protein	50.72(n) 42.9(a)		4331066 NM_001054977.1 NP_001048442.1
E. coli (Escherichia coli)	Gamma proteobacteria	qorA⁶	quinone oxidoreductase, NADPH-dependent	26(a)	1 ↔ 1	Chromosome(4261271-4262254)

ENSEMBL Gene Tree for TP53I3 (if available)
TreeFam Gene Tree for TP53I3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TP53I3 gene

VAT1² ZADH2² VAT1L² CRYZ²

4 SIMAP similar genes for TP53I3 using alignment to 3 protein entries: QORX_HUMAN (see all proteins):

CRYZ VAT1L CRYZL1 VAT1

TP53I3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10206449^1,2	C,F,	--	24039044(+)	`CAGTAA/GTCCCC`	3	--	ds500¹		8	NS NA	258
rs112778190^1,2		--	24039055(+)	`GCTGCG/CACGCC`	3	--	ds500¹		1	CSA	2
rs11883704^1,2	C,F,H,	--	24039958(+)	`gttctT/Ctgtct`	3	--	int¹		1	NA	6
rs11887770^1,2	C,F,A,H,	--	24040514(+)	`CAAAGG/CTGGTA`	3	--	int¹		11	NS NA WA CSA	348
rs36070271^1,2	C,	--	24040733(-)	`AGGTTC/TCATGC`	3	--	int¹		5	NS WA	274
rs112000851^1,2		--	24040977(+)	`GAAATC/TGGGTT`	3	--	int¹		1	CSA	2
rs35020508^1,2	C,	--	24041441(-)	`GTTTCT/CAATTC`	3	--	int¹		5	NS WA	278
rs36111458^1,2	C,	--	24041616(-)	`TCAATC/TGTGCC`	3	--	int¹		4	NS	160
rs10495746^1,2	C,F,H,	--	24041691(+)	`TAGGTT/AATTGG`	3	--	int¹		95	NS EA PA EU CA WA NA	5966
rs10204305^1,2	C,F,	--	24041984(+)	`cgagcC/Tgagat`	3	--	int¹		8	NS NA CSA	156

HapMap Linkage Disequilibrium report for TP53I3 (24300303 - 24308731 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TP53I3: --
Human Gene Mutation Database (HGMD): TP53I3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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TP53I3 for disorders           About GeneDecksing

OMIM gene information: 605171    OMIM disorders: --

18 diseases for TP53I3:    About MalaCards

constrictive pericarditis non-hodgkin lymphoma pericarditis hodgkin's lymphoma

epithelial ovarian cancer malignant glioma ovarian cancer lung cancer

pulmonary disease lung carcinoma breast carcinoma carcinoma

esophagitis tuberculosis adenocarcinoma leukemia

alcoholism mycobacterium tuberculosis

2 Novoseek disease relationships for TP53I3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ewings sarcoma	48.2	3	15192123 (3)
tumors	21.8	5	20510196 (2), 11919562 (1), 17334636 (1), 15067011 (1)

Human Genome Epidemiology (HuGE) Navigator: TP53I3 (11 documents)

Export disorders for TP53I3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TP53I3 gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with TP53I3)

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Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3. (PubMed id 19349281)^{1, 2, 3, 9} Porte S....Pares X. (2009)
UV-dependent alternative splicing uncouples p53 activity and PIG3 gene function through rapid proteolytic degradation. (PubMed id 15067011)^{1, 2, 9} Nicholls C.D.... Beattie T.L. (2004)
p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest. (PubMed id 10840161)^{1, 3, 9} Flatt P.M....Pietenpol J.A. (2000)
A polymorphic microsatellite that mediates induction of PIG3 by p53. (PubMed id 11919562)^{1, 3, 9} Contente A....Dobbelstein M. (2002)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A model for p53-induced apoptosis. (PubMed id 9305847)^{1, 2} Polyak K....Vogelstein B. (1997)
Constitutive and DNA damage inducible activation of pig3 and MDM2 genes by tumor-derived p53 mutant C277Y. (PubMed id 15192123)^{1, 9} Pospisilova S....Kovar H. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
p53-induced gene 3 mediates cell death induced by glut athione peroxidase 3. (PubMed id 22461624)¹ Wang H....Yu Y.P. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9540	HGNC: 19373	AceView: TP53I3	Ensembl:ENSG00000115129	euGenes: HUgn9540
ECgene: TP53I3	Kegg: 9540	H-InvDB: TP53I3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TP53I3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TP53I3	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/tp53i3/

Intellectual Property for TP53I3 gene
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Patent Information for TP53I3 gene:
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tumor protein p53 inducible protein 3

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tumor protein p53 inducible protein 3

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