Aliases for TP53I3 Gene
External Ids for TP53I3 Gene
The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
GeneCards Summary for TP53I3 Gene
TP53I3 (Tumor Protein P53 Inducible Protein 3) is a Protein Coding gene. Diseases associated with TP53I3 include lung cancer. Among its related pathways are Direct p53 effectors and p53 signaling pathway. GO annotations related to this gene include protein homodimerization activity and NADPH binding. An important paralog of this gene is CRYZ.
UniProtKB/Swiss-Prot for TP53I3 Gene
May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro).