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Aliases for TP53I3 Gene

Aliases for TP53I3 Gene

  • Tumor Protein P53 Inducible Protein 3 2 3
  • PIG3 3 4 6
  • P53-Induced Gene 3 Protein 3 4
  • Tumor Protein P53-Inducible Protein 3 4
  • Quinone Oxidoreductase Homolog 3
  • Quinone Oxidoreductase PIG3 3
  • EC 1.-.-.- 4

External Ids for TP53I3 Gene

Summaries for TP53I3 Gene

Entrez Gene Summary for TP53I3 Gene

  • The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for TP53I3 Gene

TP53I3 (Tumor Protein P53 Inducible Protein 3) is a Protein Coding gene. Diseases associated with TP53I3 include lung cancer. Among its related pathways are Direct p53 effectors and p53 signaling pathway. GO annotations related to this gene include protein homodimerization activity and NADPH binding. An important paralog of this gene is CRYZ.

UniProtKB/Swiss-Prot for TP53I3 Gene

  • May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro).

Gene Wiki entry for TP53I3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP53I3 Gene

Genomics for TP53I3 Gene

Genomic Location for TP53I3 Gene

Start:
24,077,433 bp from pter
End:
24,085,861 bp from pter
Size:
8,429 bases
Orientation:
Minus strand

Genomic View for TP53I3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TP53I3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53I3 Gene

Regulatory Elements for TP53I3 Gene

Transcription factor binding sites by QIAGEN in the TP53I3 gene promoter:

Proteins for TP53I3 Gene

  • Protein details for TP53I3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53FA7-QORX_HUMAN
    Recommended name:
    Quinone oxidoreductase PIG3
    Protein Accession:
    Q53FA7
    Secondary Accessions:
    • D6W533
    • O14679
    • O14685
    • Q38G78
    • Q6JLE7
    • Q9BWB8

    Protein attributes for TP53I3 Gene

    Size:
    332 amino acids
    Molecular mass:
    35536 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAC39535.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TP53I3 Gene

    Alternative splice isoforms for TP53I3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TP53I3 Gene

Proteomics data for TP53I3 Gene at MOPED

Post-translational modifications for TP53I3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TP53I3 Gene

No data available for DME Specific Peptides for TP53I3 Gene

Domains for TP53I3 Gene

Suggested Antigen Peptide Sequences for TP53I3 Gene

Graphical View of Domain Structure for InterPro Entry

Q53FA7

UniProtKB/Swiss-Prot:

QORX_HUMAN
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.:
    • Q53FA7
genes like me logo Genes that share domains with TP53I3: view

No data available for Gene Families for TP53I3 Gene

Function for TP53I3 Gene

Molecular function for TP53I3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=215 uM for 1,2-naphthoquinone {ECO:0000269 PubMed:19349281};
UniProtKB/Swiss-Prot Function: May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro).
UniProtKB/Swiss-Prot Induction: Isoform 1 and isoform 2 are both activated by p53/TP53, doxorubicin, etoposide and ionizing radiation. Isoform 2 is highly activated by UV radiation.

Enzyme Numbers (IUBMB) for TP53I3 Gene

Gene Ontology (GO) - Molecular Function for TP53I3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003960 NADPH:quinone reductase activity IDA 19349281
GO:0008270 zinc ion binding IEA --
GO:0016491 oxidoreductase activity --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
GO:0042803 protein homodimerization activity IPI 19349281
genes like me logo Genes that share ontologies with TP53I3: view

Phenotypes for TP53I3 Gene

GenomeRNAi human phenotypes for TP53I3:
genes like me logo Genes that share phenotypes with TP53I3: view

miRNA for TP53I3 Gene

miRTarBase miRNAs that target TP53I3

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TP53I3 Gene

Localization for TP53I3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TP53I3 Gene COMPARTMENTS Subcellular localization image for TP53I3 gene
Compartment Confidence
cytosol 2
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TP53I3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TP53I3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TP53I3 Gene

Pathways for TP53I3 Gene

genes like me logo Genes that share pathways with TP53I3: view

Pathways by source for TP53I3 Gene

1 BioSystems pathway for TP53I3 Gene
1 KEGG pathway for TP53I3 Gene

Gene Ontology (GO) - Biological Process for TP53I3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006739 NADP metabolic process IDA 19349281
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with TP53I3: view

Compounds for TP53I3 Gene

(15) ApexBio Compounds for TP53I3 Gene

Compound Action Cas Number
AMG232 potent and selective piperidinone inhibitor of the MDM2-p53 interaction.
CP 31398 dihydrochloride p53 stabilizing agent. [1217195-61-3]
JNJ-26854165 (Serdemetan) p53 activator, blocking Mdm2-p53 interaction [881202-45-5]
Nutlin-3 inhibitor of the MDM2/p53 interaction [890090-75-2]
Nutlin-3a chiral inhibits the MDM2-p53 interaction and activates p53. [675576-98-4]
p53 and MDM2 proteins-interaction-inhibitor chiral inhibitor of the interaction between p53 and MDM2 proteins. [939981-37-0]
Pifithrin-miu Inhibits p53 binding to mitochondria. [64984-31-2]
PRIMA-1 Cell-permeable BAX inhibitor, restore p53 activity [5608-24-2]
PRIMA-1MET Cell-permeable BAX inhibitor, restore p53 activity [5291-32-7]
RG7112 Restoration of p53 activity by inhibiting the p53-MDM2 interaction. [939981-39-2]
RG7388 Blocking the MDM2-p53 interaction stabilizes p53. [1229705-06-9]
RITA (NSC 652287) Cell-permeable antitumor agent, blocking Mdm2-p53 interaction and p53 ubiquitination [213261-59-7]
SJ 172550 Inhibits the MDMX-p53 interaction in cultured retinoblastoma cells. [431979-47-4]
Tenovin-1 Cell-permeable, reversible SIRT2 inhibitor, activates p53 [380315-80-0]
Tenovin-3 Tenovin-3 [1011301-27-1]

(7) HMDB Compounds for TP53I3 Gene

Compound Synonyms Cas Number PubMed IDs
1-Butanol
  • 1-Butanol
71-36-3
1-Hexanol
  • 1-Hexyl alcohol
111-27-3
1-Pentanol
  • 1-Pentol
71-41-0
Ethanol
  • 1-Hydroxyethane
64-17-5
Isobutanol
  • 1-Hydroxymethylpropane
78-83-1

(2) Novoseek inferred chemical compound relationships for TP53I3 Gene

Compound -log(P) Hits PubMed IDs
quinone 53.8 4
oxygen 0.348 2
genes like me logo Genes that share compounds with TP53I3: view

Transcripts for TP53I3 Gene

Unigene Clusters for TP53I3 Gene

Tumor protein p53 inducible protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TP53I3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b
SP1: - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - - - -
SP6:

Relevant External Links for TP53I3 Gene

GeneLoc Exon Structure for
TP53I3
ECgene alternative splicing isoforms for
TP53I3

Expression for TP53I3 Gene

mRNA expression in normal human tissues for TP53I3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TP53I3 Gene

This gene is overexpressed in Esophagus - Mucosa (6.4) and Colon - Transverse (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TP53I3 Gene

SOURCE GeneReport for Unigene cluster for TP53I3 Gene Hs.50649

genes like me logo Genes that share expressions with TP53I3: view

No data available for mRNA Expression by UniProt/SwissProt for TP53I3 Gene

Orthologs for TP53I3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TP53I3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TP53I3 35
  • 99.5 (n)
  • 99.4 (a)
TP53I3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TP53I3 35
  • 89.16 (n)
  • 88.86 (a)
TP53I3 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TP53I3 35
  • 88.45 (n)
  • 88.86 (a)
TP53I3 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC026585 36
  • 23 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia TP53I3 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TP53I3 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves TP53I3 35
  • 66.67 (n)
  • 68.88 (a)
TP53I3 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 22 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tp53i3 35
  • 66.67 (n)
  • 68.37 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC796473 35
  • 59.79 (n)
  • 58.41 (a)
TP53I3 36
  • 57 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZTA1 36
  • 26 (a)
OneToMany
ZTA1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G21580 35
  • 49.18 (n)
  • 43.52 (a)
rice
(Oryza sativa)
Liliopsida Os02g0805600 35
  • 51.14 (n)
  • 43.48 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01419 35
  • 52.44 (n)
  • 43.95 (a)
Species with no ortholog for TP53I3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TP53I3 Gene

ENSEMBL:
Gene Tree for TP53I3 (if available)
TreeFam:
Gene Tree for TP53I3 (if available)

Paralogs for TP53I3 Gene

Paralogs for TP53I3 Gene

Selected SIMAP similar genes for TP53I3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TP53I3: view

Variants for TP53I3 Gene

Sequence variations from dbSNP and Humsavar for TP53I3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_033032 A breast cancer sample
VAR_048201 -

Structural Variations from Database of Genomic Variants (DGV) for TP53I3 Gene

Variant ID Type Subtype PubMed ID
nsv2641 CNV Loss 18451855
dgv4070n71 CNV Gain 21882294

Relevant External Links for TP53I3 Gene

HapMap Linkage Disequilibrium report
TP53I3
Human Gene Mutation Database (HGMD)
TP53I3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TP53I3 Gene

Disorders for TP53I3 Gene

(1) MalaCards Diseases for TP53I3 Gene

Search for TP53I3 Gene in MalaCards »

(2) Novoseek inferred disease relationships for TP53I3 Gene

Disease -log(P) Hits PubMed IDs
ewings sarcoma 48.2 3
tumors 21.8 5

Relevant External Links for TP53I3

Genetic Association Database (GAD)
TP53I3
Human Genome Epidemiology (HuGE) Navigator
TP53I3
genes like me logo Genes that share disorders with TP53I3: view

No data available for UniProtKB/Swiss-Prot for TP53I3 Gene

Publications for TP53I3 Gene

  1. Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3. (PMID: 19349281) Porte S. … Pares X. (J. Biol. Chem. 2009) 2 3 4 23
  2. p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest. (PMID: 10840161) Flatt P.M. … Pietenpol J.A. (Cancer Lett. 2000) 2 3 23
  3. A polymorphic microsatellite that mediates induction of PIG3 by p53. (PMID: 11919562) Contente A. … Dobbelstein M. (Nat. Genet. 2002) 2 3 23
  4. UV-dependent alternative splicing uncouples p53 activity and PIG3 gene function through rapid proteolytic degradation. (PMID: 15067011) Nicholls C.D. … Beattie T.L. (J. Biol. Chem. 2004) 3 4 23
  5. Constitutive and DNA damage inducible activation of pig3 and MDM2 genes by tumor-derived p53 mutant C277Y. (PMID: 15192123) PospA-silovA! S. … Kovar H. (Mol. Cancer Res. 2004) 3 23

Products for TP53I3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Apoptosis 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TP53I3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TP53I3
    • Block miRNA regulation of TP53I3 using miScript Target Protectors

    Sources for TP53I3 Gene

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