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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TP53I13 Gene

protein-coding   GIFtS: 40
GCID: GC17P027895

Tumor Protein P53 Inducible Protein 13

  Search for TP53I13
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Protein P53 Inducible Protein 131 2
Damage-Stimulated Cytoplasmic Protein 12 3
DSCP12 3
Tumor Protein P53-Inducible Protein 132

External Ids:    HGNC: 251021   Entrez Gene: 903132   Ensembl: ENSG000001675437   UniProtKB: Q8NBR03   

Export aliases for TP53I13 gene to outside databases

Previous GC identifers: GC17P024920 GC17P024125


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TP53I13 Gene: 
TP53I13 (tumor protein p53 inducible protein 13) is a protein-coding gene.

UniProtKB/Swiss-Prot: P5I13_HUMAN, Q8NBR0
Function: May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010799.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TP53I13 gene promoter:
         POU2F1   p53   POU2F1a   NRSF form 1   Nkx2-5   MRF-2   NRSF form 2   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): TP53I13 promoter sequence
   Search SABiosciences Chromatin IP Primers for TP53I13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP53I13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

TP53I13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP53I13 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P027895:  view genomic region     (about GC identifiers)

Start:
27,893,070 bp from pter      End:
27,900,175 bp from pter
Size:
7,106 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: P5I13_HUMAN, Q8NBR0 (See protein sequence)
Recommended Name: Tumor protein p53-inducible protein 13 precursor  
Size: 393 amino acids; 42238 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein; Extracellular side (Potential).
Cytoplasm. Note=Associates with unknown subcellular structures in the cytoplasm
Secondary accessions: Q7L5U3

Explore the universe of human proteins at neXtProt for TP53I13: NX_Q8NBR0

Explore proteomics data for TP53I13 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NBR0

  • TP53I13 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TP53I13 Protein Expression
    REFSEQ proteins: NP_612358.3  
    ENSEMBL proteins: 
     ENSP00000465824   ENSP00000466027   ENSP00000468265   ENSP00000465112   ENSP00000462026  
     ENSP00000462693   ENSP00000301057   ENSP00000368095  

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    Cloud-Clone Corp. Proteins for TP53I13 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    TP53I13 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8NBR0


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P5I13_HUMAN, Q8NBR0
    Function: May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed
    Induction: Up-regulated by genotoxic stresses of adriamycin and/or UV irradiation in a p53/TP53-dependent manner

    Phenotypes:
         1 GenomeRNAi human phenotype for TP53I13:

     Cell cycle / mitosis defect 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TP53I13

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TP53I13 (P5I13)

    Search CenterWatch for drugs/clinical trials and news about TP53I13 / P5I13

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TP53I13 gene: 
    NM_138349.2  

    Unigene Cluster for TP53I13:

    Tumor protein p53 inducible protein 13
    Hs.514050  [show with all ESTs]
    Unigene Representative Sequence: AK093030
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000578073 ENST00000584522 ENST00000583940 ENST00000580183 ENST00000578749
    ENST00000582829 ENST00000577934 ENST00000581411 ENST00000301057(uc002hee.3)
    ENST00000580132 ENST00000579674 ENST00000378818
    miRNA
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    hsa-miR-765 hsa-miR-32* hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidTP53I13 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TP53I13
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    Additional mRNA sequence: 

    AB110209.1 AK075341.1 AK093030.1 AL137404.1 BC001593.2 BC004507.2 

    15 DOTS entries:

    DT.97855203  DT.100791517  DT.308506  DT.100791516  DT.120939574  DT.100029224  DT.75173261  DT.95313303 
    DT.92428068  DT.97855201  DT.100791511  DT.92428072  DT.120939568  DT.95173111  DT.95337389 

    24/265 AceView cDNA sequences (see all 265):

    BM142337 BM830987 BM825597 AI804622 AW572547 BM826730 BM271720 BU633082 
    BQ045229 BM823626 AI128117 CA414185 AI572856 BM676049 AI985284 BM826775 
    BM546785 BC001593 BM825634 AI565738 AW006777 AW128920 BM831108 BF591349 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TP53I13 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11
    SP1:                                                        -                 -                                       
    SP2:                          -     -     -                 -                 -                                       
    SP3:                          -     -     -                 -                 -                                       
    SP4:                                -     -                 -                                                         
    SP5:        -                       -     -                 -                                                         


    ECgene alternative splicing isoforms for TP53I13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TP53I13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTGACCT
    TP53I13 Expression
    About this image


    See TP53I13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TP53I13

    SOURCE GeneReport for Unigene cluster: Hs.514050

    UniProtKB/Swiss-Prot: P5I13_HUMAN, Q8NBR0
    Tissue specificity: Expressed in heart, placenta, skeletal muscle, testis, brain and lung

        SABiosciences Custom PCR Arrays for TP53I13
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TP53I13 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trp53i131 , 5 transformation related protein 53 inducible protein more1, 5 78.18(n)1
    71.69(a)1
      11 (46.62 cM)5
    2169641  NM_001024920.11  NP_001020091.11 
     775080995 
    lizard
    (Anolis carolinensis)
    Reptilia TP53I136
    Uncharacterized protein
    47(a)
    1 ↔ 1
    GL343462.1(344583-345220)
    zebrafish
    (Danio rerio)
    Actinopterygii CR848664.36
    Uncharacterized protein
    20(a)
    1 ↔ 1
    15(24911640-24919278)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG120936
    --
    15(a)
    1 ↔ 1
    3L(2772560-2774007)
    worm
    (Caenorhabditis elegans)
    Secernentea Y41C4A.86
    Protein Y41C4A.8
    14(a)
    1 ↔ 1
    III(11706969-11708820)


    ENSEMBL Gene Tree for TP53I13 (if available)
    TreeFam Gene Tree for TP53I13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TP53I13 gene
    1 SIMAP similar gene for TP53I13 using alignment to 8 protein entries:     P5I13_HUMAN (see all proteins):
    DKFZp434M102

    TP53I13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/103 SNPs in TP53I13 are shown (see all 103)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs775324301,2
    C,F--27896307(+) ACTGCC/TCTAAG 1 -- int13Minor allele frequency- T:0.06NA EU 1183
    rs1125630211,2
    C,F--27896342(+) TGTCAC/GCAAGA 2 P A mis12Minor allele frequency- G:0.02NA EU 1201
    rs1999505331,2
    C--27896363(+) CACGAA/GTGAGC 2 M V mis10--------
    rs800297461,2
    C,F--27896457(+) TGTTCT/AGCTGA 1 -- int11Minor allele frequency- A:0.02NA 120
    rs1821252511,2
    --27896555(+) GGACAA/GATGGC 1 -- int10--------
    rs1882860411,2
    --27896557(+) ACAGAC/TGGCTC 1 -- int10--------
    rs1397011441,2
    --27896604(+) TGTGTC/TAGGAT 1 -- int10--------
    rs1429096881,2
    --27896667(+) GAGAGC/TAGCTG 1 -- int10--------
    rs1928035651,2
    --27896726(+) GACTTC/TGTGGG 1 -- int10--------
    rs65051391,2
    C,F,A,H--27896731(+) TGTGGG/ACCCCA 1 -- int19Minor allele frequency- A:0.13NS WA NA CSA 1089

    HapMap Linkage Disequilibrium report for TP53I13 (27893070 - 27900175 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TP53I13:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv521557CNV Loss19592680
    esv22811CNV Loss19812545
    nsv908033CNV Loss21882294
    dgv3135n71CNV Loss21882294
    nsv833409CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TP53I13 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TP53I13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro. (PubMed id 14767535)1, 2, 3 Hata T.... Furukawa T. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90313 HGNC: 25102 AceView: LOC90313 Ensembl:ENSG00000167543 euGenes: HUgn90313
    ECgene: TP53I13 H-InvDB: TP53I13

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TP53I13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TP53I13 gene:
    Search GeneIP for patents involving TP53I13

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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     Proteins for TP53I13
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     inGenious Targeting Laboratory - Custom generated mouse model solutions for TP53I13
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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