TP53I13 Gene
protein-coding GIFtS: 39
GCID: GC17P027895
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|
tumor protein p53 inducible protein 13
| |
Aliases
for TP53I13 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tumor Protein P53 Inducible Protein 131 2 | | DSCP11 2 3 | | Damage-Stimulated Cytoplasmic Protein 12 3 | | Tumor Protein P53-Inducible Protein 132 |
Export aliases for TP53I13 gene to outside databasesPrevious GC identifers: GC17P024920 GC17P024125 |
Summaries
for TP53I13 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: P5I13_HUMAN, Q8NBR0Function: May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed
|
Genomic Views
for TP53I13 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TP53I13 gene promoter:
POU2F1 p53 POU2F1a NRSF form 1 Nkx2-5 MRF-2 NRSF form 2 c-Ets-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TP53I13
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP53I13 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2TP53I13 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P027895: view genomic region
(about GC identifiers)
Start:
|
27,893,070 bp from pter |
End:
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27,900,175 bp from pter |
Size:
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7,106 bases |
Orientation:
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plus strand |
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Proteins
for TP53I13 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: P5I13_HUMAN, Q8NBR0 (See
protein sequence)Recommended Name: Tumor protein p53-inducible protein 13 precursor Size: 393 amino acids; 42238 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein; Extracellular side (Potential). Cytoplasm.Note=Associates with unknown subcellular structures in the cytoplasm
Secondary accessions: Q7L5U3Explore the universe of human proteins at neXtProt for TP53I13: NX_Q8NBR0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NBR0
TP53I13 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612358.3
ENSEMBL proteins: ENSP00000465824 ENSP00000466027 ENSP00000468265 ENSP00000465112 ENSP00000462026 ENSP00000462693 ENSP00000301057 ENSP00000368095
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TP53I13 for ontologies About GeneDecksing
TP53I13 Antibody Products:
Assay Products for TP53I13: |
Protein
Domains /
Families
for TP53I13 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8NBR0 |
Function
for TP53I13 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: P5I13_HUMAN, Q8NBR0Function: May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressedInduction: Up-regulated by genotoxic stresses of adriamycin and/or UV irradiation in a p53/TP53-dependent manner
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TP53I13 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP53I13 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TP53I13 (NM_138349) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TP53I13 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53I13 |
1 GenomeRNAi human phenotype for TP53I13:
|
Pathways & Interactions
for TP53I13 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TP53I13
|
Drugs & Compounds
for TP53I13 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TP53I13
Search CenterWatch for drugs/clinical trials and news about TP53I13 / P5I13
|
Transcripts
for TP53I13 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TP53I13 gene: NM_138349.2 Unigene Cluster for TP53I13: Tumor protein p53 inducible protein 13 Hs.514050 [show with all ESTs]Unigene Representative Sequence: AK09303012 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000578073 ENST00000584522 ENST00000583940 ENST00000580183 ENST00000578749
ENST00000582829 ENST00000577934 ENST00000581411 ENST00000301057(uc002hee.3)
ENST00000580132 ENST00000579674 ENST00000378818
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TP53I13 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP53I13 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TP53I13 (NM_138349) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TP53I13 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53I13 |
Additional cDNA sequence: AB110209.1 AK075341.1 AK093030.1 AL137404.1 BC001593.2 BC004507.2 15 DOTS entries: DT.97855203 DT.100791517 DT.308506 DT.100791516 DT.120939574 DT.100029224 DT.75173261 DT.95313303 DT.92428068 DT.97855201 DT.100791511 DT.92428072 DT.120939568 DT.95173111 DT.95337389 24/265 AceView cDNA sequences (see all 265): CR612916 BM128510 CR621821 BM781681 BM825597 BM825634 BQ002179 AI985284 BE269545 BM707774 BM826714 BX283403 AW006777 CK903732 NM_138349 BF108367 BM825522 AL551604 AI565738 BU689094 BI829960 AW016839 BF591349 BG056103
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TP53I13 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | ^ | 11 |
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| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | | | | | - | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | | | | | - | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TP53I13
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Expression
for TP53I13 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TP53I13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCTGACCT
About this image
See TP53I13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TP53I13
SOURCE GeneReport for Unigene cluster: Hs.514050
UniProtKB/Swiss-Prot: P5I13_HUMAN, Q8NBR0Tissue specificity: Expressed in heart, placenta, skeletal muscle, testis, brain and lung
SABiosciences Custom PCR Arrays for TP53I13
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TP53I13
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TP53I13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TP53I13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP53I13 |
Orthologs
for TP53I13 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TP53I13 gene from 2/7 species (see all 7) About this table
ENSEMBL Gene Tree for TP53I13 (if available)
TreeFam Gene Tree for TP53I13 (if available) |
Paralogs
for TP53I13 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TP53I13 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TP53I13 (27893070 - 27900175 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TP53I13
1 CNV: 72855 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TP53I13 |
|
Disorders
/ Diseases
for TP53I13 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TP53I13 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TP53I13 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TP53I13) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro. (PubMed id 14767535)1, 2, 3 Hata T.... Furukawa T. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TP53I13 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TP53I13 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TP53I13 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TP53I13 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TP53I13 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TP53I13 gene:
Search GeneIP for patents involving TP53I13
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TP53I13 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TP53I13 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TP53I13 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TP53I13 | | | OriGene Protein Over-expression Lysate for TP53I13 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for TP53I13 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP53I13 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TP53I13 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TP53I13 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TP53I13 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP53I13 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TP53I13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP53I13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TP53I13 |
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| | | | Search Tocris compounds for TP53I13 |
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 | | | TP53I13 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for TP53I13 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53I13 |
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