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Aliases for TP53I11 Gene

Aliases for TP53I11 Gene

  • Tumor Protein P53 Inducible Protein 11 2 3 5
  • P53-Induced Gene 11 Protein 3 4
  • PIG11 3 4

External Ids for TP53I11 Gene

Previous GeneCards Identifiers for TP53I11 Gene

  • GC11M045584
  • GC11M044939
  • GC11M044889
  • GC11M044878
  • GC11M044664

Summaries for TP53I11 Gene

GeneCards Summary for TP53I11 Gene

TP53I11 (Tumor Protein P53 Inducible Protein 11) is a Protein Coding gene.

Gene Wiki entry for TP53I11 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP53I11 Gene

Genomics for TP53I11 Gene

Regulatory Elements for TP53I11 Gene

Promoters for TP53I11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TP53I11 on UCSC Golden Path with GeneCards custom track

Genomic Location for TP53I11 Gene

Chromosome:
11
Start:
44,885,903 bp from pter
End:
44,951,306 bp from pter
Size:
65,404 bases
Orientation:
Minus strand

Genomic View for TP53I11 Gene

Genes around TP53I11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TP53I11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TP53I11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53I11 Gene

Proteins for TP53I11 Gene

  • Protein details for TP53I11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14683-P5I11_HUMAN
    Recommended name:
    Tumor protein p53-inducible protein 11
    Protein Accession:
    O14683
    Secondary Accessions:
    • Q3ZCS0

    Protein attributes for TP53I11 Gene

    Size:
    189 amino acids
    Molecular mass:
    21054 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC39533.1; Type=Miscellaneous discrepancy; Note=Localized in an untranslated region: wrong choice of CDS.; Evidence={ECO:0000305};

neXtProt entry for TP53I11 Gene

Proteomics data for TP53I11 Gene at MOPED

Post-translational modifications for TP53I11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for TP53I11 Gene

Domains & Families for TP53I11 Gene

Protein Domains for TP53I11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TP53I11 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TP53I11: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TP53I11 Gene

Function for TP53I11 Gene

Molecular function for TP53I11 Gene

UniProtKB/Swiss-Prot Induction:
By p53/TP53.
genes like me logo Genes that share phenotypes with TP53I11: view

Animal Model Products

CRISPR Products

miRNA for TP53I11 Gene

miRTarBase miRNAs that target TP53I11

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TP53I11 Gene

Localization for TP53I11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP53I11 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TP53I11 Gene COMPARTMENTS Subcellular localization image for TP53I11 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 2
golgi apparatus 2
cytosol 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TP53I11 Gene

Pathways & Interactions for TP53I11 Gene

SuperPathways for TP53I11 Gene

No Data Available

Interacting Proteins for TP53I11 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309532%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000244769%0d%0a
Selected Interacting proteins: ENSP00000309532 for TP53I11 Gene via STRING

Gene Ontology (GO) - Biological Process for TP53I11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation TAS 9305847
genes like me logo Genes that share ontologies with TP53I11: view

No data available for Pathways by source and SIGNOR curated interactions for TP53I11 Gene

Drugs & Compounds for TP53I11 Gene

No Compound Related Data Available

Transcripts for TP53I11 Gene

Unigene Clusters for TP53I11 Gene

Tumor protein p53 inducible protein 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TP53I11 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - -
SP10: - - - - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - -

Relevant External Links for TP53I11 Gene

GeneLoc Exon Structure for
TP53I11
ECgene alternative splicing isoforms for
TP53I11

Expression for TP53I11 Gene

mRNA expression in normal human tissues for TP53I11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TP53I11 Gene

This gene is overexpressed in Whole Blood (x6.7).

Protein differential expression in normal tissues from HIPED for TP53I11 Gene

This gene is overexpressed in Fetal Brain (19.3), Neutrophil (8.9), and Monocytes (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TP53I11 Gene



SOURCE GeneReport for Unigene cluster for TP53I11 Gene Hs.554791

genes like me logo Genes that share expression patterns with TP53I11: view

Protein tissue co-expression partners for TP53I11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TP53I11 Gene

Orthologs for TP53I11 Gene

This gene was present in the common ancestor of animals.

Orthologs for TP53I11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TP53I11 35
  • 92.38 (n)
  • 95.21 (a)
TP53I11 36
  • 43 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TP53I11 35
  • 93.09 (n)
  • 95.74 (a)
TP53I11 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trp53i11 35
  • 85.99 (n)
  • 91.49 (a)
Trp53i11 16
Trp53i11 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TP53I11 35
  • 99.65 (n)
  • 100 (a)
TP53I11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tp53i11 35
  • 86.52 (n)
  • 92.55 (a)
oppossum
(Monodelphis domestica)
Mammalia TP53I11 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TP53I11 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves TP53I11 35
  • 79.43 (n)
  • 86.17 (a)
TP53I11 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TP53I11 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17602 35
tp53i11 35
  • 71.63 (n)
  • 77.13 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25376 35
zebrafish
(Danio rerio)
Actinopterygii tp53i11b 35
  • 69.33 (n)
  • 69.15 (a)
tp53i11a 36
  • 69 (a)
OneToMany
tp53i11b 36
  • 55 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y9C12A.1 36
  • 22 (a)
OneToOne
Species with no ortholog for TP53I11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TP53I11 Gene

ENSEMBL:
Gene Tree for TP53I11 (if available)
TreeFam:
Gene Tree for TP53I11 (if available)

Paralogs for TP53I11 Gene

No data available for Paralogs for TP53I11 Gene

Variants for TP53I11 Gene

Sequence variations from dbSNP and Humsavar for TP53I11 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs16933 -- 44,943,821(+) GTGTA(C/T)CTCCC intron-variant
rs860693 -- 44,933,830(+) CGTGT(C/G/T)GGGGG nc-transcript-variant, utr-variant-3-prime
rs865055 -- 44,933,046(+) GCAGT(A/G)GTGGC nc-transcript-variant, utr-variant-3-prime
rs968728 -- 44,950,809(+) gcagg(A/G)caggg intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs704672 -- 44,936,183(+) GCCCC(A/G)CCCAC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TP53I11 Gene

Variant ID Type Subtype PubMed ID
nsv832140 CNV Loss 17160897

Variation tolerance for TP53I11 Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 5.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TP53I11 Gene

HapMap Linkage Disequilibrium report
TP53I11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TP53I11 Gene

Disorders for TP53I11 Gene

Relevant External Links for TP53I11

Genetic Association Database (GAD)
TP53I11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TP53I11

No disorders were found for TP53I11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TP53I11 Gene

Publications for TP53I11 Gene

  1. A model for p53-induced apoptosis. (PMID: 9305847) Polyak K. … Vogelstein B. (Nature 1997) 2 3 4 67
  2. A P53 target gene, PIG11, contributes to chemosensitivity of cells to arsenic trioxide. (PMID: 15225615) Liang X.Q. … Qin J.F. (FEBS Lett. 2004) 3 23
  3. P53-induced gene 11 (PIG11) involved in arsenic trioxide-induced apoptosis in human gastric cancer MGC-803 cells. (PMID: 12883691) Liang X.Q. … Qin J.F. (Oncol. Rep. 2003) 3 23
  4. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B. … Wanker E.E. (Nucleic Acids Res. 2013) 3
  5. PIG11 is involved in hepatocellular carcinogenesis and its over-expression promotes Hepg2 cell apoptosis. (PMID: 19096915) Wu Y. … Cao E.H. (Pathol. Oncol. Res. 2009) 3

Products for TP53I11 Gene

Sources for TP53I11 Gene

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