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Aliases for TP53I11 Gene

Aliases for TP53I11 Gene

  • Tumor Protein P53 Inducible Protein 11 2 3 5
  • P53-Induced Gene 11 Protein 3 4
  • PIG11 3 4
  • Tumor Protein P53-Inducible Protein 11 3

External Ids for TP53I11 Gene

Previous GeneCards Identifiers for TP53I11 Gene

  • GC11M045584
  • GC11M044939
  • GC11M044889
  • GC11M044878
  • GC11M044664

Summaries for TP53I11 Gene

GeneCards Summary for TP53I11 Gene

TP53I11 (Tumor Protein P53 Inducible Protein 11) is a Protein Coding gene.

Gene Wiki entry for TP53I11 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP53I11 Gene

Genomics for TP53I11 Gene

Regulatory Elements for TP53I11 Gene

Enhancers for TP53I11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G045025 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -74.9 -74878 2.9 BCOR ZMYM3 MAX CEBPG FOSL1 GATA2 ADNP FOS SRF RFX1 PRDM11 TP53I11 TSPAN18 LOC105376650
GH11G045101 1.3 Ensembl ENCODE dbSUPER 12.2 -151.3 -151315 2.0 PKNOX1 RAD21 EGR1 ZNF366 ZNF143 FOS RELB ETV6 DEK EGR2 TP53I11 LOC101928812 PRDM11 LOC105376652
GH11G045100 1.1 FANTOM5 ENCODE dbSUPER 12.2 -149.4 -149386 0.4 PKNOX1 POLR2A SMARCA4 SP2 FOXA1 TP53I11 PRDM11 LOC105376652
GH11G045021 1.1 Ensembl ENCODE dbSUPER 11.5 -70.8 -70783 1.4 BCOR HDAC2 SMARCA4 ZMYM3 KDM1A PRDM10 RBBP5 PRDM11 TP53I11 LOC105376650
GH11G045024 0.9 ENCODE dbSUPER 11.4 -73.2 -73199 0.2 CTCF MAX CEBPG GABPA NR2F2 FOSL1 JUND FOS PRDM11 TP53I11 LOC105376650
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TP53I11 on UCSC Golden Path with GeneCards custom track

Promoters for TP53I11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000039364 1106 2001 SIN3A RAD21 TCF12 GLIS2 GATA2 ELK1 ZEB2 NFIC SMARCA4 KLF16

Genomic Location for TP53I11 Gene

Chromosome:
11
Start:
44,885,903 bp from pter
End:
44,951,306 bp from pter
Size:
65,404 bases
Orientation:
Minus strand

Genomic View for TP53I11 Gene

Genes around TP53I11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TP53I11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TP53I11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53I11 Gene

Proteins for TP53I11 Gene

  • Protein details for TP53I11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14683-P5I11_HUMAN
    Recommended name:
    Tumor protein p53-inducible protein 11
    Protein Accession:
    O14683
    Secondary Accessions:
    • Q3ZCS0

    Protein attributes for TP53I11 Gene

    Size:
    189 amino acids
    Molecular mass:
    21054 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC39533.1; Type=Miscellaneous discrepancy; Note=Localized in an untranslated region: wrong choice of CDS.; Evidence={ECO:0000305};

neXtProt entry for TP53I11 Gene

Post-translational modifications for TP53I11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TP53I11 Gene

Domains & Families for TP53I11 Gene

Protein Domains for TP53I11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TP53I11 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TP53I11: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TP53I11 Gene

Function for TP53I11 Gene

Molecular function for TP53I11 Gene

UniProtKB/Swiss-Prot Induction:
By p53/TP53.
genes like me logo Genes that share phenotypes with TP53I11: view

Animal Model Products

CRISPR Products

miRNA for TP53I11 Gene

miRTarBase miRNAs that target TP53I11

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TP53I11 Gene

Localization for TP53I11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP53I11 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TP53I11 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TP53I11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TP53I11: view

Pathways & Interactions for TP53I11 Gene

SuperPathways for TP53I11 Gene

No Data Available

Interacting Proteins for TP53I11 Gene

Gene Ontology (GO) - Biological Process for TP53I11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress TAS 9305847
GO:0008285 negative regulation of cell proliferation TAS 9305847
genes like me logo Genes that share ontologies with TP53I11: view

No data available for Pathways by source and SIGNOR curated interactions for TP53I11 Gene

Drugs & Compounds for TP53I11 Gene

No Compound Related Data Available

Transcripts for TP53I11 Gene

Unigene Clusters for TP53I11 Gene

Tumor protein p53 inducible protein 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TP53I11 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - -
SP10: - - - - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - -

Relevant External Links for TP53I11 Gene

GeneLoc Exon Structure for
TP53I11
ECgene alternative splicing isoforms for
TP53I11

Expression for TP53I11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TP53I11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TP53I11 Gene

This gene is overexpressed in Whole Blood (x6.7).

Protein differential expression in normal tissues from HIPED for TP53I11 Gene

This gene is overexpressed in Fetal Brain (19.3), Neutrophil (8.9), and Monocytes (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TP53I11 Gene



Protein tissue co-expression partners for TP53I11 Gene

NURSA nuclear receptor signaling pathways regulating expression of TP53I11 Gene:

TP53I11

SOURCE GeneReport for Unigene cluster for TP53I11 Gene:

Hs.554791

Evidence on tissue expression from TISSUES for TP53I11 Gene

  • Nervous system(4.7)
  • Liver(4.1)
  • Eye(2.1)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with TP53I11: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TP53I11 Gene

Orthologs for TP53I11 Gene

This gene was present in the common ancestor of animals.

Orthologs for TP53I11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TP53I11 34 35
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia TP53I11 34 35
  • 93.09 (n)
cow
(Bos Taurus)
Mammalia TP53I11 34 35
  • 92.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TP53I11 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tp53i11 34
  • 86.52 (n)
mouse
(Mus musculus)
Mammalia Trp53i11 34 16 35
  • 85.99 (n)
oppossum
(Monodelphis domestica)
Mammalia TP53I11 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves TP53I11 34 35
  • 79.43 (n)
lizard
(Anolis carolinensis)
Reptilia TP53I11 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tp53i11 34
  • 71.63 (n)
Str.17602 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25376 34
zebrafish
(Danio rerio)
Actinopterygii tp53i11b 34 35
  • 69.33 (n)
tp53i11a 35
  • 69 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y9C12A.1 35
  • 22 (a)
OneToOne
Species where no ortholog for TP53I11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TP53I11 Gene

ENSEMBL:
Gene Tree for TP53I11 (if available)
TreeFam:
Gene Tree for TP53I11 (if available)

Paralogs for TP53I11 Gene

No data available for Paralogs for TP53I11 Gene

Variants for TP53I11 Gene

Sequence variations from dbSNP and Humsavar for TP53I11 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000033701 -- 44,940,903(+) ACACT(C/T)GGTAA intron-variant
rs1000052830 -- 44,946,509(+) CTGGC(C/T)GGGAG intron-variant
rs1000172109 -- 44,947,457(+) AGAGG(A/G)GAGAA intron-variant, upstream-variant-2KB
rs1000268244 -- 44,947,716(+) GTGCT(C/T)CATCC intron-variant, upstream-variant-2KB
rs1000323269 -- 44,942,137(+) CACCA(C/T)ACATA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TP53I11 Gene

Variant ID Type Subtype PubMed ID
nsv482977 CNV gain 15286789
nsv832140 CNV loss 17160897

Variation tolerance for TP53I11 Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 5.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TP53I11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TP53I11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TP53I11 Gene

Disorders for TP53I11 Gene

Relevant External Links for TP53I11

Genetic Association Database (GAD)
TP53I11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TP53I11

No disorders were found for TP53I11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TP53I11 Gene

Publications for TP53I11 Gene

  1. A model for p53-induced apoptosis. (PMID: 9305847) Polyak K. … Vogelstein B. (Nature 1997) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A P53 target gene, PIG11, contributes to chemosensitivity of cells to arsenic trioxide. (PMID: 15225615) Liang X.Q. … Qin J.F. (FEBS Lett. 2004) 3 22 64
  4. P53-induced gene 11 (PIG11) involved in arsenic trioxide-induced apoptosis in human gastric cancer MGC-803 cells. (PMID: 12883691) Liang X.Q. … Qin J.F. (Oncol. Rep. 2003) 3 22 64
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64

Products for TP53I11 Gene

Sources for TP53I11 Gene

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