TP53BP2 Gene
protein-coding GIFtS: 59
GCID: GC01M223967
|
|
tumor protein p53 binding protein, 2(Previous names: tumor protein p53-binding protein, 2 )
| |
Aliases
for TP53BP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tumor Protein P53 Binding Protein, 21 2 | | Tumor Protein P53-Binding Protein, 21 | | ASPP21 2 3 5 | | P53BP22 | | 53BP21 2 3 | | Apoptosis-Stimulating Of P53 Protein 22 | | PPP1R13A1 2 | | Apoptosis-Stimulating Protein Of P53, 22 | | Bcl2-Binding Protein2 3 | | Bbp3 | | Renal Carcinoma Antigen NY-REN-512 3 | | P53-Binding Protein 23 | | Tumor Suppressor P53-Binding Protein 22 3 | | P53BP22 | | BBP2 3 | | |
Export aliases for TP53BP2 gene to outside databasesPrevious GC identifers: GC01P222570 GC01P219863 GC01M220469 GC01M220942 GC01M220274 GC01M222034 GC01M194580 |
Summaries
for TP53BP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TP53BP2:
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. Theprotein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized tothe perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with otherregulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoformshave been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ASPP2_HUMAN, Q13625Function: Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions.Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptoticgenes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability toinduce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by itsinteraction with DDX42
Gene Wiki entry for TP53BP2
|
Genomic Views
for TP53BP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TP53BP2 gene promoter:
STAT1 p53 STAT4 MyoD STAT1beta STAT1alpha RORalpha1 STAT2 STAT3 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for TP53BP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP53BP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q41 Ensembl cytogenetic band: 1q41 HGNC cytogenetic band: 1q41TP53BP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M223967: view genomic region
(about GC identifiers)
Start:
|
223,967,595 bp from pter |
End:
|
224,033,674 bp from pter |
Size:
|
66,080 bases |
Orientation:
|
minus strand |
|
Proteins
for TP53BP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ASPP2_HUMAN, Q13625 (See
protein sequence)Recommended Name: Apoptosis-stimulating of p53 protein 2 Size: 1128 amino acids; 125616 Da
Subunit: Binds to the central domain of TP53 as well as to BCL2. Interacts with protein phosphatase 1. Interacts withRELA NF-kappa-B subunit. This interaction probably prevents the activation of apoptosis, possibly by preventing itsinteraction with TP53. Interacts with APC2 and APPBP1. Interacts with DDX42 (via the C-terminus); the interaction isnot inhibited by TP53BP2 ubiquitination and is independent of p53/TP53
Subcellular location: Cytoplasm, perinuclear region. Nucleus. Note=Predominantly found in the perinuclear region. Somesmall fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42
Sequence caution: Sequence=AAH46150.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=AAH46150.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;Sequence=AAH58918.2; Type=Erroneous initiation;
3 PDB 3D structures from  and Proteopedia  for TP53BP2:1YCS (3D)
2UWQ (3D)
4A63 (3D)
Secondary accessions: B4DG66 Q12892 Q86X75 Q96KQ3Alternative splicing: 3 isoforms: Q13625-1 Q13625-2 Q13625-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TP53BP2: NX_Q13625
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13625
TP53BP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001026855.2 NP_005417.1
ENSEMBL proteins: ENSP00000375750 ENSP00000341957 ENSP00000417174 ENSP00000420225 ENSP00000417987 ENSP00000418252 ENSP00000375751
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TP53BP2 for ontologies About GeneDecksing
TP53BP2 Antibody Products:
Assay Products for TP53BP2: |
Protein
Domains /
Families
for TP53BP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TP53BP2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13625ProtoNet protein and cluster: Q13625 1 Blocks protein family: IPB001452 SH3 domain signature
UniProtKB/Swiss-Prot: ASPP2_HUMAN, Q13625Domain: The ankyrin repeats and the SH3 domain are required for a specific interactions with TP53Similarity: Belongs to the ASPP familySimilarity: Contains 2 ANK repeatsSimilarity: Contains 1 SH3 domain |
Function
for TP53BP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ASPP2_HUMAN, Q13625Function: Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions.Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptoticgenes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability toinduce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by itsinteraction with DDX42Induction: Following DNA damage induced by UV irradiation. Down-regulated by wild-type, but not mutant, p53/TP53 Genatlas biochemistry entry for TP53BP2:TP53 binding protein 2,cytoplasmic not binding mutant TP53
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP53BP2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for TP53BP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53BP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53BP2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
TP53BP2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for TP53BP2: Trp53bp2tm1Xlu Trp53bp2tm1Cdlo
11 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Trp53bp2):
TP53BP2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TP53BP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Activation of cAMP-Dependent PKA | | | 2 | Erythropoietin Pathway | | | 3 | Integrated Pancreatic Cancer Pathway | | | 4 | Dopamine-DARPP32 Feedback onto cAMP Pathway | | | 5 | Direct p53 effectors | |
5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TP53BP2 (see all 14)
3  BioSystems Pathways for TP53BP2
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TP53BP2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/71 Interacting proteins for TP53BP2 (Q136251, 2, 3 ENSP000003419574) via UniProtKB, MINT, STRING, and/or I2D (see all 71)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| BCL2 | P104152, 3, ENSP000003296234 | MINT-7235804 MINT-7235946 MINT-7235823 MINT-7236118 MINT-7236102 MINT-7236079 MINT-7236027 MINT-7236042 MINT-7236003 MINT-7235965 MINT-7236061 MINT-7235839 MINT-7235784 I2D:
score=4 STRING: ENSP00000329623 | | BCL2L2 | Q928432, 3, ENSP000002504054 | MINT-7235618 MINT-7235907 I2D:
score=1 STRING: ENSP00000250405 | | TP53 | P046372, 3, ENSP000002693054 | MINT-8152530 MINT-24859 I2D:
score=6 STRING: ENSP00000269305 | | BCL2L2-PABPN1 | Q928432, 3 | MINT-7235618 MINT-7235907 I2D:
score=1 | | APP | P050671, 3, ENSP000002849814 | EBI-77642,EBI-77613 I2D:
score=3 STRING: ENSP00000284981 |
About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
TP53BP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TP53BP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TP53BP2 for compounds About GeneDecksing
 Browse Tocris compounds for TP53BP2
2 Novoseek chemical compound relationships for TP53BP2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| oligonucleotide |
6.55 |
1 |
11027272 (1) |
| alanine |
3.44 |
1 |
7969167 (1) |
Search CenterWatch for drugs/clinical trials and news about TP53BP2 / ASPP2
|
Transcripts
for TP53BP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TP53BP2 gene (2 alternative transcripts): NM_001031685.2 NM_005426.2 Unigene Cluster for TP53BP2: Tumor protein p53 binding protein, 2 Hs.523968 [show with all ESTs]Unigene Representative Sequence: NM_00542615 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000391878(uc001hod.3) ENST00000343537(uc010puz.2 uc010pva.2 uc010pvb.2)
ENST00000483398 ENST00000498843 ENST00000494100 ENST00000464656 ENST00000489310
ENST00000490896 ENST00000481128 ENST00000464172 ENST00000496282 ENST00000473135
ENST00000465119 ENST00000472180 ENST00000391879
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TP53BP2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP53BP2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TP53BP2 (NM_005426) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TP53BP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53BP2 |
Additional cDNA sequence: AJ318888.2 AK294432.1 AK294654.1 AK294964.1 AK295378.1 AK316016.1 AK316103.1 AL357233.1 BC040247.1 BC046150.1 BC058918.1 U09582.1 U58334.1 11 DOTS entries: DT.100815922 DT.217014 DT.40278402 DT.91741350 DT.91815563 DT.95272890 DT.121390879 DT.92426568 DT.102832139 DT.40118500 DT.92426567 24/183 AceView cDNA sequences (see all 183): BQ001402 N74243 AV712493 BP362957 BQ023365 CA389067 R96429 AL357198 AA451644 N64445 BP350293 BQ441861 BM701426 BQ024553 AI123916 AI002719 BM707929 AU124228 AL121236 BC046150 BP336049 AL357233 CB529969 T83227
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TP53BP2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TP53BP2
|
Expression
for TP53BP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TP53BP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGAAAAAAA
About this image
See TP53BP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TP53BP2
SOURCE GeneReport for Unigene cluster: Hs.523968
UniProtKB/Swiss-Prot: ASPP2_HUMAN, Q13625Tissue specificity: Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon andperipheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressedin lung cancer cell lines
SABiosciences Expression via Pathway-Focused PCR Arrays including TP53BP2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TP53BP2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53BP2 |
Orthologs
for TP53BP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TP53BP2 gene from 6/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TP53BP21 |
tumor protein p53 binding protein, 2 |
74.88(n)
81.52(a) |
|
421329 XM_419394.3 XP_419394.3 |
lizard
(Anolis carolinensis) |
Reptilia |
TP53BP26 |
-- |
76(a) |
1 ↔ 1 |
1(245133604-245165384) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.217472 |
Xenopus laevis transcribed sequence with weak similarity more |
75.23(n) |
|
CA792216.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc90h022 |
Transcribed sequence with moderate similarity to protein more |
75.78(n) |
|
57058108 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG183753 |
-- |
57(a) |
|
57D2 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
mel-116 |
Maternal Effect Lethal family member (mel-11) |
6(a) |
possible ortholog |
II(9358472-9369040) |
ENSEMBL Gene Tree for TP53BP2 (if available)
TreeFam Gene Tree for TP53BP2 (if available) |
Paralogs
for TP53BP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TP53BP2 gene
- PPP1R16B2 PPP1R13B2 PPP1R272 PPP1R12A2 PPP1R16A2 PPP1R12B2 NRARP2 PPP1R12C2
- PPP1R13L2
7 SIMAP similar genes for TP53BP2 using alignment to 6 protein entries: ASPP2_HUMAN (see all proteins):PPP1R12A NRARP PPP1R13B PPP1R13L PPP1R27 SH3GL2
PPP1R12B
TP53BP2 for paralogs About GeneDecksing
|
Genomic Variants
for TP53BP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TP53BP2 (223967595 - 224033674 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TP53BP2
2 CNVs: 47889 3331 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TP53BP2 |
|
Disorders
/ Diseases
for TP53BP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TP53BP2 for disorders About GeneDecksing
OMIM gene information: 602143
OMIM disorders: --
18  diseases for TP53BP2: About MalaCardsrenal carcinoma adenomatous polyposis coli carcinoma renal cell carcinoma
polyposis hepatitis c osteosarcoma hepatitis b
periodontitis gastric cancer lung carcinoma hepatitis
breast carcinoma lung cancer breast cancer ataxia
prostatitis neuronitis
3 Novoseek disease relationships for TP53BP2 gene About this table
Genetic Association Database (GAD): TP53BP2
Human Genome Epidemiology (HuGE) Navigator: TP53BP2 (5 documents)
Export disorders for TP53BP2 gene to outside databases
|
Publications
for TP53BP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TP53BP2 gene, integrated from 9 sources (see all 91):
(articles sorted by number of sources associating them with TP53BP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Two cellular proteins that bind to wild-type but not mutant p53. (PubMed id 8016121)1, 2, 3, 9 Iwabuchi K....Fields S. (1994)
- The p53-binding protein 53BP2 also interacts with Bcl2 and impedes cell cycle progression at G2/M. (PubMed id 8668206)1, 2, 3 Naumovski L. and Cleary M.L. (1996)
- Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53. (PubMed id 11027272)1, 2, 9 Lopez C.D.... Naumovski L. (2000)
- Aberrant overexpression of 53BP2 mRNA in lung cancer cell lines. (PubMed id 10631318)1, 2, 9 Mori T.... Okamoto T. (2000)
- APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus. (PubMed id 10646860)1, 2, 9 Nakagawa H.... Nakamura Y. (2000)
- Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. (PubMed id 8875926)1, 2, 9 Gorina S. and Pavletich N.P. (1996)
- ASPP proteins specifically stimulate the apoptotic function of p53. (PubMed id 11684014)1, 2, 9 Samuels-Lev Y.... Lu X. (2001)
- The DEAD box protein Ddx42p modulates the function of ASPP2, a stimulator of apoptosis. (PubMed id 19377511)1, 2 Uhlmann-Schiffler H....Stahl H. (2009)
- Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold. (PubMed id 17594908)1, 2 Tidow H....Fersht A.R. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
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External Searches for TP53BP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing TP53BP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing TP53BP2 gene
(According to HUGE)
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Specialized Databases showing TP53BP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for TP53BP2 gene:
Search GeneIP for patents involving TP53BP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TP53BP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TP53BP2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TP53BP2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TP53BP2 | | | OriGene Protein Over-expression Lysate for TP53BP2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for TP53BP2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP53BP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TP53BP2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TP53BP2 | | OriGene Custom Protein Services for TP53BP2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TP53BP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TP53BP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP53BP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TP53BP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP53BP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TP53BP2 |
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| | | | Search Tocris compounds for TP53BP2 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53BP2 |
|  |  |  | | | | ThermoFisher Antibodies for TP53BP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53BP2 |
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