V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

TP53BP1 Gene

protein-coding GIFtS: 65

GC15M041486

tumor protein p53 binding protein 1
(Previous names: tumor protein p53-binding protein, 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
53BP1 ^¹, ², ³, ⁵
FLJ41424 ^²
MGC138366 ^²
p202 ^¹, ²
p53BP1 ^³

Descriptions
p53-binding protein 1 ^³
tumor protein 53-binding protein, 1 ^²
tumor protein p53 binding protein 1 ^²
tumor protein p53-binding protein, 1 ^¹, ²

External Ids
HGNC: 11999¹
Entrez Gene: 7158²
UniProtKB: Q12888³
Ensembl: ENSG00000067369⁷

Search outside databases for aliases for TP53BP1 gene

Previous GC identifers: GC15M039066 GC15M036595 GC15M041278 GC15M041415

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TP53B_HUMAN, Q12888

Function: May have a role in checkpoint signaling during mitosis (By similarity). Enhances

TP53-mediated transcriptional activation. Plays a role in the response to DNA damage

Gene Wiki entry for TP53BP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TP53BP1 gene

Entrez Gene cytogenetic band: 15q15-q21 Ensembl cytogenetic band: 15q15.3 HGNC cytogenetic band: 15q15-q21

TP53BP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M041486: (about GC identifiers)

Start:	41,486,699 bp from pter
End:	41,590,028 bp from pter
Size:	103,330 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TP53B_HUMAN, Q12888 (See protein sequence)

Recommended Name: Tumor suppressor p53-binding protein 1

Size: 1972 amino acids; 213574 Da

Subunit: Interacts with IFI202A (By similarity). Binds to the central domain of TP53/p53. May form

homo-oligomers. Interacts with DCLRE1C. Interacts with histone H2AFX and this requires

phosphorylation of H2AFX on 'Ser-139'. Interacts with histone H4 that has been dimethylated at

'Lys-20'. Has low affinity for histone H4 containing monomethylated 'Lys-20'. Does not bind

histone H4 containing unmethylated or trimethylated 'Lys-20'. Has low affinity for histone H3 that

has been dimethylated on 'Lys-79'. Has very low affinity for histone H3 that has been

monomethylated on 'Lys-79' (in vitro). Does not bind unmethylated histone H3

Subcellular location: Nucleus. Kinetochore. Note=Associated with kinetochores. Both nuclear and

cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks.

Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand

breaks

PDB structures from and Proteopedia :

1GZH (3D)

1KZY (3D)

1XNI (3D)

2G3R (3D)

2IG0 (3D)

Secondary accessions: Q2M1Z7 Q4LE46 Q5FWZ3 Q7Z3U4

Alternative splicing: 2 isoforms: Q12888-1 Q12888-2

Post-translational modifications:

Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding¹

Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an

ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated

in an ATR-dependent manner in response to DNA damage induced by UV irradiation¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001135451.1 NP_001135452.1 NP_005648.1

ENSEMBL proteins:

ENSP00000371470 ENSP00000263801 ENSP00000384078 ENSP00000371475

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (53BP1)
	Human Recombinant Proteins from Abnova (TP53BP1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000777	condensed chromosome kinetochore	IEA	--
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	IDA	9748285
GO:0005657	replication fork	IEA	--

About this table

Antibodies for TP53BP1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of TP53BP1
	Sigma-Aldrich Antibody Arrays and Antibodies for TP53BP1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for TP53BP1 (53BP1)
	Antibodies from Abcam (53BP1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TP53BP1)
	Novus Biologicals Antibodies for TP53BP1

Assays for TP53BP1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q12888

ProtoNet protein and cluster: Q12888

1 Blocks protein family: IPB001357 BRCT domain

UniProtKB/Swiss-Prot: TP53B_HUMAN, Q12888

Similarity: Contains 2 BRCT domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TP53BP1)
		Millipore RNAi Products for the Analysis of TP53BP1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (TP53BP1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_005657

Applied Biosystems Silencer® siRNAs for TP53BP1

Sigma-Aldrich siRNA for TP53BP1

Sigma-Aldrich shRNA Panels and shRNA for TP53BP1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001141979
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001141979
untagged cDNA clones in CMV expression vector (see all 3): NM_001141979

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001141980

UniProtKB/Swiss-Prot: TP53B_HUMAN, Q12888

Function: May have a role in checkpoint signaling during mitosis (By similarity). Enhances

TP53-mediated transcriptional activation. Plays a role in the response to DNA damage

Genatlas biochemistry entry for TP53BP1:

TP53 binding protein 1,nuclear and cytoplasmic not binding mutant TP53

6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Trp53bp1):

cellular	growth/size	hematopoietic system	immune system	reproductive system
tumorigenesis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003684	damaged DNA binding	IEA	--
GO:0005515	protein binding	IPI	12607005 17525332
GO:0016563	transcription activator activity	NAS	9748285

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for TP53BP1 (Your Favorite Gene powered by Ingenuity)

ATM Signaling

GeneDecks TP53BP1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for TP53BP1

5/28 Interacting proteins for TP53BP1 (Q12888^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 28 )
Interactant Interaction Details
GeneCard External ID(s)
H2AFX P16104¹^,² EBI-396540, EBI-494830 MINT-3378379 EBI-396540, EBI-494830 MINT-3378379
BRCA1 P38398¹ EBI-396540, EBI-349905
H2AFX P16104¹^,² EBI-396540, EBI-494830 MINT-3378379 EBI-396540, EBI-494830 MINT-3378379
HIST1H3A P68431² MINT-2829648 MINT-2830088 MINT-2829755 MINT-2831063 MINT-2829121 MINT-2830502
HIST1H3B P68431² MINT-2829648 MINT-2830088 MINT-2829755 MINT-2831063 MINT-2829121 MINT-2830502
About this table
4 Gene Ontology (GO) biological process terms (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006350 transcription IEA --
GO:0006974 response to DNA damage stimulus IEA --
GO:0045893 positive regulation of transcription, DNA-dependent NAS 9748285
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TP53BP1
7 Novoseek chemical compound relationships for TP53BP1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
p202	97.26	179	11007452 (10), 8910340 (9), 10074903 (7), 8619867 (7) (see all 25)
mnda	82.01	1	17981573 (1)
wortmannin	39.15	2	11331310 (1), 12956959 (1)
lysine	7.48	2	18026117 (1), 19203579 (1), 18840612 (1)
cytosine	5.02	1	16096014 (1)
oxygen	0.00	1	17575156 (1)
tyrosine	0.00	1	15492236 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TP53BP1)
		Millipore RNAi Products for the Analysis of TP53BP1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (TP53BP1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_005657

Sigma-Aldrich siRNA for TP53BP1

Sigma-Aldrich shRNA Panels and shRNA for TP53BP1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001141979 NM_001141980 NM_005657

REFSEQ mRNAs for TP53BP1 gene (3 alternative transcripts):

NM_001141979.1 NM_001141980.1 NM_005657.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001141979 NM_001141980 NM_005657

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001141979
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001141979
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001141979

Additional cDNA sequence:

AB210025.1 AF078776.1 AK123418.1 AK292915.1 AK295764.1 AK307405.1 BC017846.1 BC063119.1

BC112161.1 BX537418.1 DQ102772.1 U09477.1

17 DOTS entries:

DT.95301122 DT.40258937 DT.40116929 DT.121049061 DT.97794060 DT.75133574 DT.92439720 DT.75141971

DT.91680834 DT.75133335 DT.95360903 DT.97811257 DT.102831478 DT.95150757 DT.95358247 DT.91814478

DT.95337473

24/287 AceView cDNA sequences (see all 287 ):

BQ683784 BQ900363 AF078776 NM_005657 BU684930 BG252079 BQ876960 AW029221

AI923372 BU542194 BM793263 BC017846 AW372650 BQ671093 AL699447 AA334786

AA235833 AA406444 BM926929 AW372648 AI417874 BP368782 CA313822 BM677886

highest scoring ESTs for TP53BP1:

AF078776 AA062699 AA069347 AA069382 AA235833 AA334786 AA406444 AA410461 AA442066 AA442170

Unigene Cluster for TP53BP1:

Tumor protein p53 binding protein 1

Hs.440968 [show with all ESTs]

Unigene Representative Sequence: AF078776

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TP53BP1 (see all 11 )

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	·	14c	^	15	^	16	^	17a	·	17b	·	17c	^	18a	·	18b	^	19a	·	19b	^
SP1:																																					-		-								-
SP2:																																					-		-								-
SP3:			-		-		-																														-		-								-
SP4:
SP5:

ExUns:	20a	·	20b	^	21	^	22	^	23	^	24	^	25	^	26	^	27a	·	27b	^	28a	·	28b	^	29	^	30a	·	30b	^	31	^	32	^	33	^	34
SP1:																	-								-
SP2:																	-								-
SP3:																	-								-
SP4:																									-
SP5:																	-

About this scheme

ECgene alternative splicing isoforms for TP53BP1

4 Ensembl transcripts including schematic representations:

ENST00000382039 ENST00000263801 ENST00000404183 ENST00000382044

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TP53BP1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TP53BP1

¹ / ² / ³

5 probe-sets matching TP53BP1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1711_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U09477	0.60	1.00	0.82	1
203050_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005657	0.60	1.00	0.82	1
1569097_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1569098_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203050_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GATCTTGTAT

SOURCE GeneReport for Unigene cluster: Hs.440968
Expression variation in blood from EXPOLDB for TP53BP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TP53BP1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TP53BP1¹	--	tumor protein p53 binding protein 1	91.35(n) 89.38(a)	478274 XM_854700.1 XP_859793.1
chimpanzee (Pan troglodytes)	TP53BP1¹	--	tumor protein p53 binding protein 1	99.58(n) 99.24(a)	467668 XM_001158163.1 XP_001158163.1
cow (Bos taurus)	TP53BP1¹	--	tumor protein p53 binding protein 1	89.71(n) 87.96(a)	509111 XM_865493.2 XP_870586.2
rat (Rattus norvegicus)	Tp53bp1¹	--	tumor protein p53 binding protein 1	85.31(n) 82.48(a)	296099 XM_215812.4 XP_215812.4
mouse (Mus musculus)	Trp53bp1^{1, 5}	2⁵	transformation related protein 53 binding protein 1^{1, 5}	85.19(n)¹ 81.99(a)¹	27223¹ NM_013735.2¹ NP_038763.2¹ AA032380⁵ AI593074⁵ (see all 23)

About this table Species with no ortholog for TP53BP1

ENSEMBL Gene Tree for TP53BP1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/623 NCBI SNPs in TP53BP1 are shown (see all 623 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 167)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2602141^1,2	A,C,F,H,O	41511938(+)	`TTCCTG/TATTAG`	1	K/Q	mis¹		28	EU EA NA WA MN CSAM NS	2304
	rs689647^1,2	A,C,F,H,O	41549488(+)	`TTCACC/TACTTT`	1	G/S	mis¹		29	EA NA MN EU WA CSAM NS	2210
	rs560191^1,2	A,C,F,H,O	41555066(+)	`AGACTC/GTCCTG`	1	D/E	mis¹		32	EA NA MN EU WA CSAM NS	2484
--	rs2242067^1,2	A,C,F,O	41486595(+)	`CTTGGC/TCAGCT`	1	--	ng5¹		5	NS	190
--	rs2242068^1,2	A,C,F,O	41486596(+)	`TTGGCC/GAGCTG`	1	--	ng5¹		5	NS	190
	rs1869258^1,2	A,C,F,H	41590913(+)	`TCCTTA/CCTGCA`	1	--	ng3¹		10	EA EU WA NS	1906
--	rs11554564^1,2	C,F,H	41499999(-)	`TTGTAG/TGGCTC`	1	G/W	mis¹ ese³		9	MN CSAM EA EU WA	792
	rs3803339^1,2	C,F,H	41511824(-)	`AGACTA/GTAAAG`	1	I/V	mis¹ ese³		22	MN CSAM EA EU WA NS	1828
	rs34823068^1,2	C,F	41535987(+)	`ACCCTT/CGGGAC`	1	R/Q	mis¹		10	NA EU EA WA NS	668
	rs2256238^1,2	C,H	41526951(+)	`CTTTAG/AGCAAA`	1	L/P	mis¹ ese³		9	EU EA WA MN CSAM	822

About this table

HapMap Linkage Disequilibrium images for TP53BP1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605230

10/15 Novoseek disease relationships for TP53BP1 gene (see all 15 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ataxia telangiectasia	79.45	17	14695167 (2), 12697768 (1), 15279780 (1), 11801725 (1) (see all 12)
retinoblastoma	46.09	7	7890747 (2), 9233764 (1), 8524315 (1), 9766636 (1) (see all 6)
cancer	36.71	18	12447382 (2), 17546051 (2), 15856006 (1), 17143500 (1) (see all 12)
tumors	28.64	41	17637749 (3), 12884364 (3), 10646849 (3), 17522062 (3) (see all 21)
chromosomal aberrations	19.36	2	17591918 (1), 18804090 (1)
breast cancer	8.40	10	10646849 (4), 14978302 (1), 16314399 (1), 18006705 (1) (see all 6)
necrosis	4.20	3	10646849 (3)
metastasis	4.02	1	11585747 (1)
shock	0.00	1	15768430 (1)
melanoma	0.00	3	15816840 (1), 17932567 (1)

About this table

Human Gene Mutation Database: TP53BP1
Genetic Association Database: TP53BP1
Human Genome Epidemiology Navigator: TP53BP1 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/207 PubMed articles for TP53BP1 gene (see all 207 ):

Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2. (PubMed id 9748285)^{1, 2, 3, 4} Iwabuchi K....Fields S. (1998)
Two cellular proteins that bind to wild-type but not mutant p53. (PubMed id 8016121)^{1, 2, 3, 4} Iwabuchi K....Fields S. (1994)
The GAR motif of 53BP1 is arginine methylated by PRMT1 and is necessary for 53BP1 DNA binding activity. (PubMed id 16294045)^{1, 3, 4} Boisvert F.-M.... Doherty A.J. (2005)
53BP1 oligomerization is independent of its methylation by PRMT1. (PubMed id 16294047)^{1, 3, 4} Adams M.M.... Carpenter P.B. (2005)
Negative cell cycle regulation and DNA-damage inducible phosphorylation of the BRCT protein 53BP1. (PubMed id 11042216)^{1, 3, 4} Xia Z.... Carpenter P.B. (2001)
Joint effects of single nucleotide polymorphisms in P53BP1 and p53 on breast cancer risk in a Chinese population. (PubMed id 16314399)^{1, 3, 6} Ma H....Shen H. (2006)
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. (PubMed id 15574327)^{1, 3, 4} Riballo E.... Loebrich M. (2004)
MDC1 is a mediator of the mammalian DNA damage checkpoint. (PubMed id 12607005)^{1, 3, 4} Stewart G.S....Elledge S.J. (2003)
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. (PubMed id 11877378)^{1, 3, 4} Joo W.S....Pavletich N.P. (2002)
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)^{3, 4} Matsuoka S.... Elledge S.J. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7158	HGNC: 11999	AceView: TP53BP1	Ensembl:ENSG00000067369	euGenes: HUgn7158
ECgene: TP53BP1	H-InvDB: TP53BP1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TP53BP1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/tp53bp1/

Licensable Technologies for TP53BP1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TP53BP1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TP53BP1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TP53BP1		Antibodies for TP53BP1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TP53BP1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TP53BP1)
	Antibodies (TP53BP1)
	Chimera RNAi (TP53BP1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for TP53BP1 (53BP1)

	Recombinant Proteins (53BP1)
	Antibodies (53BP1)

Search OriGene for TP53BP1

Search Tocris compounds for TP53BP1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TP53BP1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
TP53BP1 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

TP53BP1 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for TP53BP1

Summaries
for TP53BP1

Genomic Location
for TP53BP1

Proteins
for TP53BP1

Protein Domains/
Families
for TP53BP1

Gene Function
for TP53BP1

Pathways & Interactions
for TP53BP1

Drugs & Compounds
for TP53BP1

Transcripts
for TP53BP1

Expression
for TP53BP1

Orthologs
for TP53BP1

Paralogs
for TP53BP1

SNPs/Variants
for TP53BP1

Disorders & Mutations
for TP53BP1

Medical News
for TP53BP1

Publications
for TP53BP1

Search for TP53BP1

Genome Databases showing TP53BP1

Other Databases showing TP53BP1

Specialized Databases showing TP53BP1

Licensable Technologies
for TP53BP1

Services
for TP53BP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TP53BP1 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor TP53BP1

Summariesfor TP53BP1

Genomic Locationfor TP53BP1

Proteinsfor TP53BP1

Protein Domains/Familiesfor TP53BP1

Gene Functionfor TP53BP1

Pathways & Interactionsfor TP53BP1

Drugs & Compoundsfor TP53BP1

Transcriptsfor TP53BP1

Expression for TP53BP1

Orthologsfor TP53BP1

Paralogsfor TP53BP1

SNPs/Variantsfor TP53BP1

Disorders & Mutationsfor TP53BP1

Medical Newsfor TP53BP1

Publicationsfor TP53BP1

Search for TP53BP1

Genome Databases showing TP53BP1

Other Databases showing TP53BP1

Specialized Databases showing TP53BP1

Licensable Technologiesfor TP53BP1

Servicesfor TP53BP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TP53BP1

Summaries
for TP53BP1

Genomic Location
for TP53BP1

Proteins
for TP53BP1

Protein Domains/
Families
for TP53BP1

Gene Function
for TP53BP1

Pathways & Interactions
for TP53BP1

Drugs & Compounds
for TP53BP1

Transcripts
for TP53BP1

Expression
for TP53BP1

Orthologs
for TP53BP1

Paralogs
for TP53BP1

SNPs/Variants
for TP53BP1

Disorders & Mutations
for TP53BP1

Medical News
for TP53BP1

Publications
for TP53BP1

Licensable Technologies
for TP53BP1

Services
for TP53BP1