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TP53AIP1 Gene

protein-coding   GIFtS: 51
GCID: GC11M128805

Tumor Protein P53 Regulated Apoptosis Inducing Protein 1

  See TP53AIP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Protein P53 Regulated Apoptosis Inducing Protein 11 2
P53AIP12 5
P53-Regulated Apoptosis-Inducing Protein 12
p53AIP13

External Ids:    HGNC: 299841   Entrez Gene: 639702   Ensembl: ENSG000001204717   OMIM: 6054265   UniProtKB: Q9HCN23   

Export aliases for TP53AIP1 gene to outside databases

Previous GC identifers: GC11M128313 GC11M124756


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TP53AIP1 Gene:
This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion.
The expression of this gene is inducible by p53, and it is thought to play an important role in mediating
p53-dependent apoptosis. Alternatively spliced transcript variants encoding different isoforms have been
described for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for TP53AIP1 Gene:
TP53AIP1 (tumor protein p53 regulated apoptosis inducing protein 1) is a protein-coding gene. Diseases associated with TP53AIP1 include oral leukoplakia, and brain cancer.

UniProtKB/Swiss-Prot: TPIP1_HUMAN, Q9HCN2
Function: May play an important role in mediating p53/TP53-dependent apoptosis

Gene Wiki entry for TP53AIP1 (P53AIP1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the TP53AIP1 gene promoter:
         C/EBPbeta   POU2F1   POU2F1a   Pax-6   HSF1 (long)   HSF1short   FOXD3   Pax-2   Pax-2a   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTP53AIP1 promoter sequence
   Search Chromatin IP Primers for TP53AIP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TP53AIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24   Ensembl cytogenetic band:  11q24.3   HGNC cytogenetic band: 11q24.3

TP53AIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP53AIP1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M128805:  view genomic region     (about GC identifiers)

Start:
128,804,626 bp from pter      End:
128,813,294 bp from pter
Size:
8,669 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TPIP1_HUMAN, Q9HCN2 (See protein sequence)
Recommended Name: p53-regulated apoptosis-inducing protein 1  
Size: 124 amino acids; 12935 Da
Secondary accessions: Q6NT40 Q7Z6F7 Q9HCN0 Q9HCN1
Alternative splicing: 4 isoforms:  Q9HCN2-1   Q9HCN2-2   Q9HCN2-3   Q9HCN2-4   (Dubious isoform. Could be a cloning artifact)

Explore the universe of human proteins at neXtProt for TP53AIP1: NX_Q9HCN2

REFSEQ proteins (4 alternative transcripts): 
NP_001182123.1  NP_001182124.1  NP_001238893.1  NP_071395.2  

ENSEMBL proteins: 
 ENSP00000390694   ENSP00000432743   ENSP00000432908   ENSP00000435175   ENSP00000473353  

TP53AIP1 Human Recombinant Protein Products:

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antibodies-online proteins for TP53AIP1 (3 products) 

 
antibodies-online peptides for TP53AIP1

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q9HCN2


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TPIP1_HUMAN, Q9HCN2
Function: May play an important role in mediating p53/TP53-dependent apoptosis
Induction: By p53/TP53

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
     
Find genes that share ontologies with TP53AIP1           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for TP53AIP1

miRNA
Products:
    
miRTarBase miRNAs that target TP53AIP1:
hsa-mir-335-5p (MIRT017230)

Block miRNA regulation of human, mouse, rat TP53AIP1 using miScript Target Protectors
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SwitchGear 3'UTR luciferase reporter plasmidTP53AIP1 3' UTR sequence
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Predesigned siRNA for gene silencing in human, mouse, rat TP53AIP1

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Sino Biological Human cDNA Clone for TP53AIP1
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53AIP1

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53AIP1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TPIP1_HUMAN, Q9HCN2: Mitochondrion
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
extracellular2
nucleus2
cytosol1
peroxisome1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion TAS11030628

Find genes that share ontologies with TP53AIP1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TP53AIP1 About    
See pathways by source

SuperPathContained pathways About
1p53 signaling pathway
DNA damage response0.41
p53 signaling pathway0.41
2p53 pathway
p53 pathway


Find genes that share SuperPaths with TP53AIP1           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TP53AIP1
    p53 Mediated Apoptosis
Mitochondrial Apoptosis
Cellular Apoptosis Pathway

2 BioSystems Pathways for TP53AIP1
    DNA damage response
p53 pathway



1 Kegg Pathway  (Kegg details for TP53AIP1):
    p53 signaling pathway

    Pathway & Disease-focused RT2 Profiler PCR Array including TP53AIP1: 
          p53 Signaling Pathway in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for TP53AIP1

1 Interacting protein for TP53AIP1 (Q9HCN23) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
BCL2P104153I2D: score=2 
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006915apoptotic process TAS11030628

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TP53AIP1 (TPIP1)

1 Novoseek inferred chemical compound relationship for TP53AIP1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
roscovitine 84.6 1 17384267 (1)



Find genes that share compounds with TP53AIP1           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TP53AIP1 gene (4 alternative transcripts): 
NM_001195194.1  NM_001195195.1  NM_001251964.1  NM_022112.2  

Unigene Cluster for TP53AIP1:

Tumor protein p53 regulated apoptosis inducing protein 1
Hs.160953  [show with all ESTs]
Unigene Representative Sequence: NM_001251964
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000458238(uc021qsc.1) ENST00000531399(uc021qsd.1) ENST00000525390(uc001qey.3 uc001qex.3)
ENST00000530777 ENST00000527504(uc009zcm.2) ENST00000602346
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Predesigned siRNA for gene silencing in human, mouse, rat TP53AIP1
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for TP53AIP1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53AIP1
Primer
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  QuantiFast Probe-based Assays in human, mouse, rat TP53AIP1

Additional mRNA sequence: 

AB045830.1 AB045831.1 AB045832.1 AK310612.1 AK314286.1 AY302135.1 BC069399.1 BC069426.1 
EF693749.1 

4 DOTS entries:

DT.70104873  DT.95319810  DT.75126983  DT.92419343 

23 AceView cDNA sequences:

AB045832 NM_022112 AB045830 BF511020 BF927093 BF738212 BX281723 AI566771 
BX460289 AV732015 AB045831 AI383639 BG678978 AY302135 BX431573 AL703609 
BC069426 BG682489 BE931336 BC069399 AV750921 AV730428 AI872153 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TP53AIP1    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5
SP1:                                      -     -                                 
SP2:                                      -     -           -     -     -         
SP3:                                      -     -           -                     
SP4:                                                                              
SP5:                    -                                                         


ECgene alternative splicing isoforms for TP53AIP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TP53AIP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGCAGGACAA
TP53AIP1 Expression
About this image

TP53AIP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.160953

UniProtKB/Swiss-Prot: TPIP1_HUMAN, Q9HCN2
Tissue specificity: Only found to be expressed in thymus

    Pathway & Disease-focused RT2 Profiler PCR Array including TP53AIP1: 
          p53 Signaling Pathway in human mouse rat

Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53AIP1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for TP53AIP1 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia TP53AIP11 tumor protein p53 regulated apoptosis inducing protein more 98.66(n)
97.58(a)
  100609662  XM_003952070.1  XP_003952119.1 


ENSEMBL Gene Tree for TP53AIP1 (if available)
TreeFam Gene Tree for TP53AIP1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TP53AIP1 gene
1 SIMAP similar gene for TP53AIP1 using alignment to 1 protein entry:     TPIP1_HUMAN:
P53AIP1

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TP53AIP1 (see all 273)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2006960701,2
Cuntested1128675434(+) ATCCAA/GACGAG 7 S F mis1 ut310--------
rs346224001,2
C--124762754(+) GGACA-/CTCTGCA 3 -- int10--------
rs1442437491,2
C--128673133(+) CTCCAC/TTACAC 1 -- int10--------
rs1922463881,2
--128673140(+) ACACAC/TGTGAT 1 -- int10--------
rs1461065951,2
--128673408(+) ACCTGG/TACCTC 1 -- int10--------
rs1399146981,2
--128673429(+) ACCACA/GGGCTT 1 -- int10--------
rs1847696681,2
--128673485(+) GCAAGC/TGATCC 1 -- int10--------
rs1880227191,2
--128673486(+) CAAGCA/GATCCC 1 -- int10--------
rs1434071901,2
--128673521(+) TACTCC/TGCAGG 1 -- int10--------
rs1913332951,2
--128673522(+) ACTCCA/GCAGGG 1 -- int10--------

HapMap Linkage Disequilibrium report for TP53AIP1 (128804626 - 128813294 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for TP53AIP1:    About this table    
Variant IDTypeSubtypePubMed ID
esv2097474CNV Deletion18987734
dgv84n21CNV Loss19592680
nsv468892CNV Loss19166990

Human Gene Mutation Database (HGMD): TP53AIP1
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TP53AIP1
DNA2.0 Custom Variant and Variant Library Synthesis for TP53AIP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605426    OMIM disorders: --

2 diseases for TP53AIP1:    
About MalaCards
oral leukoplakia    brain cancer


Find genes that share disorders with TP53AIP1           About GenesLikeMe

3 Novoseek inferred disease relationships for TP53AIP1 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer 28.1 1 15657359 (1)
tumors 9.27 4 17611651 (1), 17079449 (1), 15657359 (1)
cancer 8.67 1 17079449 (1)

Genetic Association Database (GAD): TP53AIP1
Human Genome Epidemiology (HuGE) Navigator: TP53AIP1 (2 documents)

Export disorders for TP53AIP1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TP53AIP1 gene, integrated from 10 sources (see all 29):
(articles sorted by number of sources associating them with TP53AIP1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. (PubMed id 11030628)1, 2, 3, 9 Oda K.... Taya Y. (Cell 2000)
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
  3. p53AIP1 regulates the mitochondrial apoptotic pathway. (PubMed id 12019168)1, 3 Matsuda K....Arakawa H. (Cancer Res. 2002)
  4. Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells. (PubMed id 15657359)1, 9 Wesierska-Gadek J....Horky M. (Mol. Cancer Ther. 2005)
  5. Anti-apoptotic roles for the mutant p53R248Q through suppression of p53-regulated apoptosis-inducing protein 1 in the RA-derived fibroblast-like synoviocyte cell line MH7A. (PubMed id 24316591)1 Igarashi H....Ishihara K. (Clin. Immunol. 2014)
  6. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PubMed id 23319000)1 Luykx J.J....Ophoff R.A. (Mol. Psychiatry 2013)
  7. Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis. (PubMed id 22334068)1 Yuan L....Zhang L. (EMBO Rep. 2012)
  8. Prostate cancer risk is not altered by TP53AIP1 germline mutations in a German case-control series. (PubMed id 22457820)1 Luedeke M....Maier C. (PLoS ONE 2012)
  9. Combination of p53AIP1 and survivin expression is a powerful prognostic marker in non-small cell lung cancer. (PubMed id 19228369)1 Yamashita S....Kawahara K. (amp 2009)
  10. Difference of p53AIP1 mRNA expression in gastric mucosa between patients with gastric cancer and chronic gastritis infected with Helicobacter pylori. (PubMed id 18277906)1 Sawaya M....Fukuda S. (J. Clin. Gastroenterol. 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 63970 HGNC: 29984 AceView: P53AIP1 Ensembl:ENSG00000120471 euGenes: HUgn63970
ECgene: TP53AIP1 Kegg: 63970 H-InvDB: TP53AIP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TP53AIP1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TP53AIP1 gene:
Search GeneIP for patents involving TP53AIP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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