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Aliases for TP53AIP1 Gene

Aliases for TP53AIP1 Gene

  • Tumor Protein P53 Regulated Apoptosis Inducing Protein 1 2 3
  • P53AIP1 3 4 6
  • P53-Regulated Apoptosis-Inducing Protein 1 3

External Ids for TP53AIP1 Gene

Summaries for TP53AIP1 Gene

Entrez Gene Summary for TP53AIP1 Gene

  • This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. The expression of this gene is inducible by p53, and it is thought to play an important role in mediating p53-dependent apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for TP53AIP1 Gene

TP53AIP1 (Tumor Protein P53 Regulated Apoptosis Inducing Protein 1) is a Protein Coding gene. Diseases associated with TP53AIP1 include oral leukoplakia and brain cancer. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Apoptotic Pathways in Synovial Fibroblasts.

UniProtKB/Swiss-Prot for TP53AIP1 Gene

  • May play an important role in mediating p53/TP53-dependent apoptosis.

Gene Wiki entry for TP53AIP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP53AIP1 Gene

Genomics for TP53AIP1 Gene

Genomic Location for TP53AIP1 Gene

Start:
128,934,731 bp from pter
End:
128,943,399 bp from pter
Size:
8,669 bases
Orientation:
Minus strand

Genomic View for TP53AIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TP53AIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53AIP1 Gene

Regulatory Elements for TP53AIP1 Gene

Proteins for TP53AIP1 Gene

  • Protein details for TP53AIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCN2-TPIP1_HUMAN
    Recommended name:
    p53-regulated apoptosis-inducing protein 1
    Protein Accession:
    Q9HCN2
    Secondary Accessions:
    • Q6NT40
    • Q7Z6F7
    • Q9HCN0
    • Q9HCN1

    Protein attributes for TP53AIP1 Gene

    Size:
    124 amino acids
    Molecular mass:
    12935 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TP53AIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TP53AIP1 Gene

Proteomics data for TP53AIP1 Gene at MOPED

Post-translational modifications for TP53AIP1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TP53AIP1 Gene

Domains for TP53AIP1 Gene

Protein Domains for TP53AIP1 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with TP53AIP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TP53AIP1 Gene

Function for TP53AIP1 Gene

Molecular function for TP53AIP1 Gene

UniProtKB/Swiss-Prot Function: May play an important role in mediating p53/TP53-dependent apoptosis.
UniProtKB/Swiss-Prot Induction: By p53/TP53.

Gene Ontology (GO) - Molecular Function for TP53AIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TP53AIP1: view

miRNA for TP53AIP1 Gene

miRTarBase miRNAs that target TP53AIP1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TP53AIP1 Gene

Localization for TP53AIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP53AIP1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TP53AIP1 Gene COMPARTMENTS Subcellular localization image for TP53AIP1 gene
Compartment Confidence
mitochondrion 5
extracellular 2
nucleus 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TP53AIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS 11030628
genes like me logo Genes that share ontologies with TP53AIP1: view

Pathways for TP53AIP1 Gene

genes like me logo Genes that share pathways with TP53AIP1: view

Pathways by source for TP53AIP1 Gene

2 BioSystems pathways for TP53AIP1 Gene
1 KEGG pathway for TP53AIP1 Gene

Interacting Proteins for TP53AIP1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000432743%0d%0a9606.ENSP00000329623%0d%0a9606.ENSP00000269305%0d%0a9606.ENSP00000262982%0d%0a
Selected Interacting proteins: ENSP00000432743 Q9HCN2-TPIP1_HUMAN for TP53AIP1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TP53AIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 11030628
genes like me logo Genes that share ontologies with TP53AIP1: view

Compounds for TP53AIP1 Gene

(1) Novoseek inferred chemical compound relationships for TP53AIP1 Gene

Compound -log(P) Hits PubMed IDs
roscovitine 84.6 1
genes like me logo Genes that share compounds with TP53AIP1: view

Transcripts for TP53AIP1 Gene

Unigene Clusters for TP53AIP1 Gene

Tumor protein p53 regulated apoptosis inducing protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TP53AIP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5
SP1: - -
SP2: - - - - -
SP3: - - -
SP4:
SP5: -

Relevant External Links for TP53AIP1 Gene

GeneLoc Exon Structure for
TP53AIP1
ECgene alternative splicing isoforms for
TP53AIP1

Expression for TP53AIP1 Gene

mRNA expression in normal human tissues for TP53AIP1 Gene

mRNA differential expression in normal tissues according to GTEx for TP53AIP1 Gene

This gene is overexpressed in Esophagus - Mucosa (12.1), Skin - Not Sun Exposed (Suprapubic) (9.7), Skin - Sun Exposed (Lower leg) (8.4), and Vagina (6.8).

SOURCE GeneReport for Unigene cluster for TP53AIP1 Gene Hs.160953

mRNA Expression by UniProt/SwissProt for TP53AIP1 Gene

Q9HCN2-TPIP1_HUMAN
Tissue specificity: Only found to be expressed in thymus.
genes like me logo Genes that share expressions with TP53AIP1: view

Orthologs for TP53AIP1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TP53AIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TP53AIP1 36
  • 98.66 (n)
  • 97.58 (a)
TP53AIP1 37
  • 98 (a)
OneToOne
Species with no ortholog for TP53AIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TP53AIP1 Gene

ENSEMBL:
Gene Tree for TP53AIP1 (if available)
TreeFam:
Gene Tree for TP53AIP1 (if available)

Paralogs for TP53AIP1 Gene

Selected SIMAP similar genes for TP53AIP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TP53AIP1: view

No data available for Paralogs for TP53AIP1 Gene

Variants for TP53AIP1 Gene

Sequence variations from dbSNP and Humsavar for TP53AIP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2155548 -- 128,934,894(+) GTAGA(A/C)TATGG downstream-variant-500B, utr-variant-3-prime
rs2186833 -- 128,935,060(+) CAAAA(C/T)AAAAC downstream-variant-500B, intron-variant
rs2604224 -- 128,938,691(+) CAGGG(C/T)GGCGG upstream-variant-2KB, intron-variant
rs2604235 -- 128,942,676(-) CGGAA(A/G)GTACA intron-variant
rs2846689 -- 128,937,311(+) TCCCC(A/G)TGCGC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TP53AIP1 Gene

Variant ID Type Subtype PubMed ID
nsv468892 CNV Loss 19166990
dgv84n21 CNV Loss 19592680
esv2097474 CNV Deletion 18987734

Relevant External Links for TP53AIP1 Gene

HapMap Linkage Disequilibrium report
TP53AIP1
Human Gene Mutation Database (HGMD)
TP53AIP1

Disorders for TP53AIP1 Gene

(3) Novoseek inferred disease relationships for TP53AIP1 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 28.1 1
tumors 9.27 3
cancer 8.67 1

Relevant External Links for TP53AIP1

Genetic Association Database (GAD)
TP53AIP1
Human Genome Epidemiology (HuGE) Navigator
TP53AIP1
genes like me logo Genes that share disorders with TP53AIP1: view

No data available for UniProtKB/Swiss-Prot for TP53AIP1 Gene

Publications for TP53AIP1 Gene

  1. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. (PMID: 11030628) Oda K. … Taya Y. (Cell 2000) 2 3 4 23
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 49
  3. Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells. (PMID: 15657359) Wesierska-Gadek J. … Horky M. (Mol. Cancer Ther. 2005) 3 23
  4. p53AIP1 regulates the mitochondrial apoptotic pathway. (PMID: 12019168) Matsuda K. … Arakawa H. (Cancer Res. 2002) 2 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TP53AIP1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • p53 Signaling Pathway in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TP53AIP1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TP53AIP1
    • Block miRNA regulation of TP53AIP1 using miScript Target Protectors

    Sources for TP53AIP1 Gene

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