TP53AIP1 Gene
protein-coding GIFtS: 50
GCID: GC11M128805
|
|
tumor protein p53 regulated apoptosis inducing protein 1
| |
Aliases
for TP53AIP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tumor Protein P53 Regulated Apoptosis Inducing Protein 11 2 | | P53AIP12 5 | | P53AIP12 5 | | P53-Regulated Apoptosis-Inducing Protein 12 |
Export aliases for TP53AIP1 gene to outside databasesPrevious GC identifers: GC11M128313 GC11M124756 |
Summaries
for TP53AIP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TP53AIP1:
This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. Theexpression of this gene is inducible by p53, and it is thought to play an important role in mediating p53-dependentapoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.(provided by RefSeq, Oct 2011)
UniProtKB/Swiss-Prot: TPIP1_HUMAN, Q9HCN2Function: May play an important role in mediating p53/TP53-dependent apoptosis
Gene Wiki entry for TP53AIP1 (P53AIP1)
|
Genomic Views
for TP53AIP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TP53AIP1 gene promoter:
C/EBPbeta POU2F1 POU2F1a Pax-6 HSF1 (long) HSF1short FOXD3 Pax-2 Pax-2a YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TP53AIP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP53AIP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q24 Ensembl cytogenetic band: 11q24.3 HGNC cytogenetic band: 11q24.3TP53AIP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M128805: view genomic region
(about GC identifiers)
Start:
|
128,804,626 bp from pter |
End:
|
128,813,040 bp from pter |
Size:
|
8,415 bases |
Orientation:
|
minus strand |
|
Proteins
for TP53AIP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TPIP1_HUMAN, Q9HCN2 (See
protein sequence)Recommended Name: p53-regulated apoptosis-inducing protein 1 Size: 124 amino acids; 12935 Da
Subcellular location: Mitochondrion
Secondary accessions: Q6NT40 Q7Z6F7 Q9HCN0 Q9HCN1Alternative splicing: 4 isoforms: Q9HCN2-1 Q9HCN2-2 Q9HCN2-3 Q9HCN2-4 (Dubious isoform. Could be a cloning artifact)Explore the universe of human proteins at neXtProt for TP53AIP1: NX_Q9HCN2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HCN2
TP53AIP1 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins (4 alternative transcripts):
NP_001182123.1 NP_001182124.1 NP_001238893.1 NP_071395.2
ENSEMBL proteins: ENSP00000390694 ENSP00000432743 ENSP00000432908 ENSP00000435175
Human Recombinant Protein Products for TP53AIP1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
TP53AIP1 for ontologies About GeneDecksing
TP53AIP1 Antibody Products:
Assay Products for TP53AIP1: |
Protein
Domains /
Families
for TP53AIP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9HCN2 |
Function
for TP53AIP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TPIP1_HUMAN, Q9HCN2Function: May play an important role in mediating p53/TP53-dependent apoptosisInduction: By p53/TP53 Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
TP53AIP1 for ontologies About GeneDecksing
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP53AIP1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for TP53AIP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53AIP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53AIP1 |
|
Pathways & Interactions
for TP53AIP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | p53 signaling pathway | | | 2 | p53 pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for TP53AIP1
1 
Kegg Pathway (Kegg details for TP53AIP1):
TP53AIP1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TP53AIP1
1 Interacting protein for TP53AIP1 (Q9HCN23) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
TP53AIP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TP53AIP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TP53AIP1 for compounds About GeneDecksing
 Browse Tocris compounds for TP53AIP1
1 Novoseek chemical compound relationship for TP53AIP1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| roscovitine |
84.6 |
1 |
17384267 (1) |
Search CenterWatch for drugs/clinical trials and news about TP53AIP1 / TPIP1
|
Transcripts
for TP53AIP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TP53AIP1 gene (4 alternative transcripts): NM_001195194.1 NM_001195195.1 NM_001251964.1 NM_022112.2 Unigene Cluster for TP53AIP1: Tumor protein p53 regulated apoptosis inducing protein 1 Hs.160953 [show with all ESTs]Unigene Representative Sequence: NM_0012519645 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000458238(uc021qsc.1) ENST00000531399(uc021qsd.1) ENST00000525390(uc001qey.3 uc001qex.3)
ENST00000530777 ENST00000527504(uc009zcm.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TP53AIP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TP53AIP1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): TP53AIP1 (NM_022112) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TP53AIP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53AIP1 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TP53AIP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TP53AIP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TP53AIP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP53AIP1 |
Additional cDNA sequence: AB045830.1 AB045831.1 AB045832.1 AK310612.1 AK314286.1 AY302135.1 BC069399.1 BC069426.1 EF693749.1 4 DOTS entries: DT.70104873 DT.95319810 DT.75126983 DT.92419343 23 AceView cDNA sequences: NM_022112 AB045830 AB045832 BG678978 AY302135 BX431573 AI566771 AI383639 AB045831 BX460289 BF738212 AL703609 BF511020 BX281723 BF927093 AV732015 BC069399 AV750921 BE931336 BC069426 BG682489 AV730428 AI872153
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TP53AIP1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | - | | - | | - | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TP53AIP1
|
Expression
for TP53AIP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TP53AIP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCAGGACAA
About this image
Genevestigator expression for TP53AIP1
SOURCE GeneReport for Unigene cluster: Hs.160953
UniProtKB/Swiss-Prot: TPIP1_HUMAN, Q9HCN2Tissue specificity: Only found to be expressed in thymus
SABiosciences Expression via Pathway-Focused PCR Array including TP53AIP1: | p53 Signaling Pathway in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TP53AIP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TP53AIP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TP53AIP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP53AIP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53AIP1 |
Orthologs
for TP53AIP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for TP53AIP1 (if available)
TreeFam Gene Tree for TP53AIP1 (if available) |
Paralogs
for TP53AIP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TP53AIP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TP53AIP1 (128804626 - 128813040 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TP53AIP1
1 CNV: 48730
Human Gene Mutation Database (HGMD): TP53AIP1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TP53AIP1 |
|
Disorders
/ Diseases
for TP53AIP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TP53AIP1 for disorders About GeneDecksing
OMIM gene information: 605426
OMIM disorders: --
12  diseases for TP53AIP1: About MalaCardsoral leukoplakia leukoplakia brain cancer gastritis
breast cancer hepatocellular carcinoma gastric cancer lung cancer
prostate cancer prostatitis carcinoma leukemia
3 Novoseek disease relationships for TP53AIP1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| breast cancer |
28.1 |
1 |
15657359 (1) |
| tumors |
9.27 |
4 |
17611651 (1), 17079449 (1), 15657359 (1) |
| cancer |
8.67 |
1 |
17079449 (1) |
Human Genome Epidemiology (HuGE) Navigator: TP53AIP1 (2 documents)
Export disorders for TP53AIP1 gene to outside databases
|
Publications
for TP53AIP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TP53AIP1 gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with TP53AIP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. (PubMed id 11030628)1, 2, 3, 9 Oda K.... Taya Y. (2000)
- p53AIP1 regulates the mitochondrial apoptotic pathway. (PubMed id 12019168)1, 3 Matsuda K....Arakawa H. (2002)
- Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells. (PubMed id 15657359)1, 9 Wesierska-Gadek J....Horky M. (2005)
- Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis. (PubMed id 22334068)1 Yuan L....Zhang L. (2012)
- Prostate cancer risk is not altered by TP53AIP1 germli ne mutations in a German case-control series. (PubMed id 22457820)1 Luedeke M....Maier C. (2012)
- Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1 Flachsbart F....Nebel A. (2010)
- Combination of p53AIP1 and survivin expression is a p owerful prognostic marker in non-small cell lung cancer. (PubMed id 19228369)1 Yamashita S....Kawahara K. (2009)
- Difference of p53AIP1 mRNA expression in gastric mucosa between patients with gastric cancer and chronic gastritis infected with Helicobacter pylori. (PubMed id 18277906)1 Sawaya M....Fukuda S. (2008)
- p53AIP1 expression can be a prognostic marker in non-small cell lung cancer. (PubMed id 17851056)1 Yamashita S.I....Kawahara K. (2008)
- Insights in gastric carcinogenesis from Helicobacter pylori infection. (PubMed id 18277909)1 Daniele B. (2008)
|
External Searches for TP53AIP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TP53AIP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TP53AIP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TP53AIP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TP53AIP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TP53AIP1 gene:
Search GeneIP for patents involving TP53AIP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TP53AIP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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 | | | TP53AIP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53AIP1 |
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