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Aliases for TP53AIP1 Gene

Aliases for TP53AIP1 Gene

  • Tumor Protein P53 Regulated Apoptosis Inducing Protein 1 2 3 5
  • P53AIP1 3 4

External Ids for TP53AIP1 Gene

Previous GeneCards Identifiers for TP53AIP1 Gene

  • GC11M128313
  • GC11M128805
  • GC11M124756

Summaries for TP53AIP1 Gene

Entrez Gene Summary for TP53AIP1 Gene

  • This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. The expression of this gene is inducible by p53, and it is thought to play an important role in mediating p53-dependent apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for TP53AIP1 Gene

TP53AIP1 (Tumor Protein P53 Regulated Apoptosis Inducing Protein 1) is a Protein Coding gene. Among its related pathways are Gene Expression and p53 pathway (Pathway Interaction Database).

UniProtKB/Swiss-Prot for TP53AIP1 Gene

  • May play an important role in mediating p53/TP53-dependent apoptosis.

Gene Wiki entry for TP53AIP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP53AIP1 Gene

Genomics for TP53AIP1 Gene

Regulatory Elements for TP53AIP1 Gene

Genomic Location for TP53AIP1 Gene

Chromosome:
11
Start:
128,934,731 bp from pter
End:
128,943,399 bp from pter
Size:
8,669 bases
Orientation:
Minus strand

Genomic View for TP53AIP1 Gene

Genes around TP53AIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TP53AIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TP53AIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53AIP1 Gene

Proteins for TP53AIP1 Gene

  • Protein details for TP53AIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCN2-TPIP1_HUMAN
    Recommended name:
    p53-regulated apoptosis-inducing protein 1
    Protein Accession:
    Q9HCN2
    Secondary Accessions:
    • Q6NT40
    • Q7Z6F7
    • Q9HCN0
    • Q9HCN1

    Protein attributes for TP53AIP1 Gene

    Size:
    124 amino acids
    Molecular mass:
    12935 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TP53AIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TP53AIP1 Gene

Proteomics data for TP53AIP1 Gene at MOPED

Post-translational modifications for TP53AIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TP53AIP1 Gene

Domains & Families for TP53AIP1 Gene

Protein Domains for TP53AIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TP53AIP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TP53AIP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TP53AIP1 Gene

Function for TP53AIP1 Gene

Molecular function for TP53AIP1 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in mediating p53/TP53-dependent apoptosis.
UniProtKB/Swiss-Prot Induction:
By p53/TP53.
genes like me logo Genes that share phenotypes with TP53AIP1: view

Animal Model Products

CRISPR Products

miRNA for TP53AIP1 Gene

miRTarBase miRNAs that target TP53AIP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TP53AIP1 Gene

Localization for TP53AIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP53AIP1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TP53AIP1 Gene COMPARTMENTS Subcellular localization image for TP53AIP1 gene
Compartment Confidence
mitochondrion 5
extracellular 2
nucleus 2
cytosol 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TP53AIP1 Gene

Pathways & Interactions for TP53AIP1 Gene

genes like me logo Genes that share pathways with TP53AIP1: view

Pathways by source for TP53AIP1 Gene

Interacting Proteins for TP53AIP1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000432743%0d%0a9606.ENSP00000329623%0d%0a9606.ENSP00000269305%0d%0a9606.ENSP00000262982%0d%0a
Selected Interacting proteins: ENSP00000432743 Q9HCN2-TPIP1_HUMAN for TP53AIP1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TP53AIP1 Gene

None

No data available for SIGNOR curated interactions for TP53AIP1 Gene

Drugs & Compounds for TP53AIP1 Gene

(1) Drugs for TP53AIP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TP53AIP1: view

Transcripts for TP53AIP1 Gene

Unigene Clusters for TP53AIP1 Gene

Tumor protein p53 regulated apoptosis inducing protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TP53AIP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5
SP1: - -
SP2: - - - - -
SP3: - - -
SP4:
SP5: -

Relevant External Links for TP53AIP1 Gene

GeneLoc Exon Structure for
TP53AIP1
ECgene alternative splicing isoforms for
TP53AIP1

Expression for TP53AIP1 Gene

mRNA expression in normal human tissues for TP53AIP1 Gene

mRNA differential expression in normal tissues according to GTEx for TP53AIP1 Gene

This gene is overexpressed in Esophagus - Mucosa (x12.1), Skin - Not Sun Exposed (Suprapubic) (x9.7), Skin - Sun Exposed (Lower leg) (x8.4), and Vagina (x6.8).

SOURCE GeneReport for Unigene cluster for TP53AIP1 Gene Hs.160953

mRNA Expression by UniProt/SwissProt for TP53AIP1 Gene

Q9HCN2-TPIP1_HUMAN
Tissue specificity: Only found to be expressed in thymus.
genes like me logo Genes that share expression patterns with TP53AIP1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TP53AIP1 Gene

Orthologs for TP53AIP1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TP53AIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TP53AIP1 35
  • 98.66 (n)
  • 97.58 (a)
TP53AIP1 36
  • 98 (a)
OneToOne
Species with no ortholog for TP53AIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TP53AIP1 Gene

ENSEMBL:
Gene Tree for TP53AIP1 (if available)
TreeFam:
Gene Tree for TP53AIP1 (if available)

Paralogs for TP53AIP1 Gene

(1) SIMAP similar genes for TP53AIP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TP53AIP1: view

No data available for Paralogs for TP53AIP1 Gene

Variants for TP53AIP1 Gene

Sequence variations from dbSNP and Humsavar for TP53AIP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs35942033 - 128,937,799(-) TGAGG(C/T)GAGCT reference, missense
rs2155548 -- 128,934,894(+) GTAGA(A/C/T)TATGG downstream-variant-500B, utr-variant-3-prime
rs2186833 -- 128,935,060(+) CAAAA(C/T)AAAAC intron-variant, downstream-variant-500B
rs2604224 -- 128,938,691(+) CAGGG(C/T)GGCGG intron-variant, upstream-variant-2KB
rs2604235 -- 128,942,676(-) CGGAA(A/G)GTACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TP53AIP1 Gene

Variant ID Type Subtype PubMed ID
nsv468892 CNV Loss 19166990
dgv84n21 CNV Loss 19592680
esv2097474 CNV Deletion 18987734

Variation tolerance for TP53AIP1 Gene

Residual Variation Intolerance Score: 86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TP53AIP1 Gene

HapMap Linkage Disequilibrium report
TP53AIP1
Human Gene Mutation Database (HGMD)
TP53AIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TP53AIP1 Gene

Disorders for TP53AIP1 Gene

Relevant External Links for TP53AIP1

Genetic Association Database (GAD)
TP53AIP1
Human Genome Epidemiology (HuGE) Navigator
TP53AIP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TP53AIP1

No disorders were found for TP53AIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TP53AIP1 Gene

Publications for TP53AIP1 Gene

  1. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. (PMID: 11030628) Oda K. … Taya Y. (Cell 2000) 2 3 4 23 67
  2. Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells. (PMID: 15657359) Wesierska-Gadek J. … Horky M. (Mol. Cancer Ther. 2005) 3 23
  3. p53AIP1 regulates the mitochondrial apoptotic pathway. (PMID: 12019168) Matsuda K. … Arakawa H. (Cancer Res. 2002) 2 3
  4. Anti-apoptotic roles for the mutant p53R248Q through suppression of p53-regulated apoptosis-inducing protein 1 in the RA-derived fibroblast-like synoviocyte cell line MH7A. (PMID: 24316591) Igarashi H. … Ishihara K. (Clin. Immunol. 2014) 3
  5. [Effect of p53-regulated apoptosis-inducing protein 1 transfection on the biological characteristics of PC-3M human prostate cancer cells]. (PMID: 25108434) Lin X. … Yu J. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2014) 3

Products for TP53AIP1 Gene

Sources for TP53AIP1 Gene

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