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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TP53 Gene

protein-coding   GIFtS: 81
GCID: GC17M007565

Tumor Protein P53

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 5

Aliases
Tumor Protein P531 2     BCC72
P532 3 5     TRP532
Antigen NY-CO-132 3     Cellular Tumor Antigen P532
Phosphoprotein P532 3     P53 Tumor Suppressor2
LFS12 5     Transformation-Related Protein 532
Li-Fraumeni Syndrome1     Tumor Suppressor P533

External Ids:    HGNC: 119981   Entrez Gene: 71572   Ensembl: ENSG000001415107   OMIM: 1911705   UniProtKB: P046373   
ORGUL members:    fRNAdb10:FR343586 FR325937      
H-InvDB12:HIT000195796    
NCBI13:U58658 M55576    
NONCODE14:n335267 n337087 n343020      
RNAdb15:LIT1750 HIV2718    

Export aliases for TP53 gene to outside databases

Previous GC identifers: GC17P008026 GC17M008311 GC17M007514 GC17M007772 GC17M007512 GC17M007465


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TP53 Gene:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and
oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of
target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism.
Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as
Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple
transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate
translation initiation codons (PMIDs: 12032546, 20937277). (provided by RefSeq, Feb 2013)

GeneCards Summary for TP53 Gene: 
TP53 (tumor protein p53) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with TP53 include li-fraumeni syndrome, and adrenocortical carcinoma, and among its related super-pathways are Glioma and Endometrial cancer. GO annotations related to this gene include identical protein binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TP73.

UniProtKB/Swiss-Prot: P53_HUMAN, P04637
Function: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the
physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to
negatively regulate cell division by controlling a set of genes required for this process. One of the activated
genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation
of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF
is involved in activating oxidative stress-induced necrosis; the function is largely independent of
transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1.
LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to
effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when
associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the
transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses
transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform
1-mediated apoptosis

summary for TP53 Gene:
p53 (aka TP53) is a transcription factor whose protein levels and post-translational modification state
alter in response to cellular stress (such as DNA damage, hypoxia, spindle damage). Activation of p53 begins
through a number of mechanisms including phosphorylation by ATM, ATR, Chk1 and MAPKs. MDM2 is a ubiquitn
ligase that binds p53 and targets p53 for proteasomal degradation. Phosphorylation, p14ARF and USP7 prevent
MDM2-p53 interactions, leading to an increase in stable p53 tetramers in the cytoplasm. Further
modifications such as methylation and acetylation lead to an increase in p53 binding to gene specific
response elements. p53 regulates a large number of genes (>100 genes) that control a number of key tumor
suppressing functions such as cell cycle arrest, DNA repair, senescence and apoptosis. Whilst the activation
of p53 often leads to apoptosis, p53 inactivation facilitates tumor progression; inactivating p53 mutations
occur in over 50% of cancers.

Gene Wiki entry for TP53 (P53) Gene

fRNAdb sequence ontologies for TP53 - the ORGUL cluster for this gene includes several descriptions:
intron - A region of a primary transcript that is transcribed, but removed from within the transcript by splicing together the sequences (exons) on either side of it.
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for TP53

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TP53 gene promoter:
         CREB   C/EBPbeta   Sp1   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): TP53 promoter sequence
   Search SABiosciences Chromatin IP Primers for TP53

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP53


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

TP53 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP53 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007565:  view genomic region     (about GC identifiers)

Start:
7,565,097 bp from pter      End:
7,590,863 bp from pter
Size:
25,767 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TP53

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: P53_HUMAN, P04637 (See protein sequence)
Recommended Name: Cellular tumor antigen p53  
Size: 393 amino acids; 43653 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1 (By similarity).
Binds DNA as a homotetramer. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and
CARM1, and recruits them to promoters. In vitro, the interaction of TP53 with cancer-associated/HPV (E6) viral
proteins leads to ubiquitination and degradation of TP53 giving a possible model for cell growth regulation. This
complex formation requires an additional factor, E6-AP, which stably associates with TP53 in the presence of E6.
Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this
interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1.
Interacts with WWOX. May interact with HCV core protein. Interacts with USP7 and SYVN1. Interacts with HSP90AB1.
Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity (By similarity).
Interacts with ARMC10, BANP, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F1. Interacts with YWHAZ; the interaction
enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts
(via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus).
Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with
FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the
phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation.
Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-382)
with L3MBTL1. Isoform 1 interacts with isoform 2 and with isoform 4. Interacts with GRK5. Binds to the CAK
complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with
AURKB, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2.
Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the
association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by
cyclosporin A (CsA). Interacts with human cytomegalovirus/HHV-5 protein UL123. Interacts with SNAI1; the
interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion.
Interacts with KAT6A. Interacts with UBC9. Interacts with ZNF385B; the interaction is direct. Interacts (via
DNA-binding domain) with ZNF385A; the interaction is direct and enhances p53/TP53 transactivation functions on
cell-cycle arrest target genes, resulting in growth arrest
Subcellular location: Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix.
Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2.
Translocates to mitochondria upon oxidative stress
Subcellular location: Isoform 1: Nucleus. Cytoplasm. Note=Predominantly nuclear but localizes to the cytoplasm
when expressed with isoform 4
Subcellular location: Isoform 2: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in
the cytoplasm
Subcellular location: Isoform 3: Nucleus. Cytoplasm. Note=Localized in the nucleus in most cells but found in the
cytoplasm in some cells
Subcellular location: Isoform 4: Nucleus. Cytoplasm. Note=Predominantly nuclear but translocates to the cytoplasm
following cell stress
Subcellular location: Isoform 7: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in
the cytoplasm
Subcellular location: Isoform 8: Nucleus. Cytoplasm. Note=Localized in both nucleus and cytoplasm in most cells.
In some cells, forms foci in the nucleus that are different from nucleoli
Subcellular location: Isoform 9: Cytoplasm
6/103 PDB 3D structures from and Proteopedia for TP53 (see all 103):
1A1U (3D)        1AIE (3D)        1C26 (3D)        1DT7 (3D)        1GZH (3D)        1H26 (3D)    
Secondary accessions: Q15086 Q15087 Q15088 Q16535 Q16807 Q16808 Q16809 Q16810 Q16811 Q16848
Q2XN98 Q3LRW1 Q3LRW2 Q3LRW3 Q3LRW4 Q3LRW5 Q86UG1 Q8J016 Q99659 Q9BTM4 Q9HAQ8 Q9NP68 Q9NPJ2
Q9NZD0 Q9UBI2 Q9UQ61
Alternative promoter usage, Alternative splicing: 9 isoforms:  P04637-1   P04637-2   P04637-3   P04637-4   P04637-5   P04637-6   P04637-7   P04637-8   
P04637-9   (Produced by alternative promoter usage and alternative splicing)

Explore the universe of human proteins at neXtProt for TP53: NX_P04637

Explore proteomics data for TP53 at MOPED 

Post-translational modifications:

  • UniProtKB: Acetylated. Acetylation of Lys-382 by CREBBP enhances transcriptional activity. Deacetylation of Lys-382 by SIRT1
    impairs its ability to induce proapoptotic program and modulate cell senescence
  • UniProtKB: Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylated by HIPK1 (By similarity).
    Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter. Phosphorylated on Thr-18 by
    VRK1. Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2.
    Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated
    apoptosis. Phosphorylated on Thr-55 by TAF1, which promotes MDM2-mediated degradation. Phosphorylated on Ser-33
    by CDK7 in a CAK complex in response to DNA damage. Phosphorylated on Ser-46 by HIPK2 upon UV irradiation.
    Phosphorylation on Ser-46 is required for acetylation by CREBBP. Phosphorylated on Ser-392 following UV but not
    gamma irradiation. Phosphorylated on Ser-15 upon ultraviolet irradiation; which is enhanced by interaction with
    BANP. Phosphorylated by NUAK1 at Ser-15 and Ser-392; was intially thought to be mediated by STK11/LKB1 but it was
    later shown that it is indirect and that STK11/LKB1-dependent phosphorylation is probably mediated by downstream
    NUAK1 (PubMed:21317932). It is unclear whether AMP directly mediates phosphorylation at Ser-15. Phosphorylated on
    Thr-18 by isoform 1 and isoform 2 of VRK2. Phosphorylation on Thr-18 by isoform 2 of VRK2 results in a reduction
    in ubiquitination by MDM2 and an increase in acetylation by EP300. Stabilized by CDK5-mediated phosphorylation in
    response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53,
    particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated by DYRK2
    at Ser-46 in response to genotoxic stress. Phosphorylated at Ser-315 and Ser-392 by CDK2 in response to
    DNA-damage
  • UniProtKB: Dephosphorylated by PP2A-PPP2R5C holoenzyme at Thr-55. SV40 small T antigen inhibits the dephosphorylation by the
    AC form of PP2A
  • UniProtKB: May be O-glycosylated in the C-terminal basic region. Studied in EB-1 cell line
  • UniProtKB: Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in
    cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not
    targeted to the proteasome. Ubiquitinated by MKRN1 at Lys-291 and Lys-292, which leads to proteasomal
    degradation. Deubiquitinated by USP10, leading to its stabilization. Ubiquitinated by TRIM24, which leads to
    proteasomal degradation. Ubiquitination by TOPORS induces degradation. Deubiquitination by USP7, leading to
    stabilization. Isoform 4 is monoubiquitinated in an MDM2-independent manner
  • UniProtKB: Monomethylated at Lys-372 by SETD7, leading to stabilization and increased transcriptional activation.
    Monomethylated at Lys-370 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional
    regulation activity. Lys-372 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at
    Lys-370. Dimethylated at Lys-373 by EHMT1 and EHMT2. Monomethylated at Lys-382 by SETD8, promoting interaction
    with L3MBTL1 and leading to repress transcriptional activity. Dimethylation at Lys-370 and Lys-382 diminishes p53
    ubiquitination, through stabilizing association with the methyl reader PHF20. Demethylation of dimethylated
    Lys-370 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation
  • UniProtKB: Sumoylated with SUMO1. Sumoylated at Lys-386 by UBC9
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04637

  • TP53 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TP53 Protein Expression
    REFSEQ proteins (15 alternative transcripts): 
    NP_000537.3  NP_001119584.1  NP_001119585.1  NP_001119586.1  NP_001119587.1  NP_001119588.1  NP_001119589.1  NP_001119590.1  
    NP_001263624.1  NP_001263625.1  NP_001263626.1  NP_001263627.1  NP_001263628.1  NP_001263689.1  NP_001263690.1  

    ENSEMBL proteins: 
     ENSP00000410739   ENSP00000352610   ENSP00000269305   ENSP00000398846   ENSP00000391127  
     ENSP00000391478   ENSP00000458393   ENSP00000425104   ENSP00000423862   ENSP00000424104  
     ENSP00000473895   ENSP00000426252  
    Reactome Protein details: P04637
    Human Recombinant Protein Products for TP53: 
    EMD Millipore Purified and/or Recombinant TP53 Protein
    R&D Systems Recombinant & Natural Proteins for TP53 (p53)
    Enzo Life Sciences proteins for TP53
    OriGene Purified Proteins for TP53
    OriGene Protein Over-expression Lysate for TP53
    OriGene MassSpec for TP53 
    OriGene Custom Protein Services for TP53
    GenScript Custom Purified and Recombinant Proteins Services for TP53
    Novus Biologicals TP53 Proteins
    Novus Biologicals TP53 Lysates
    Sino Biological Recombinant Protein for TP53
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TP53
    Cloud-Clone Corp. Proteins for TP53 

    Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IBA--
    GO:0000790nuclear chromatin IDA15710329
    GO:0005634nucleus IDA14744935
    GO:0005654nucleoplasm TAS--
    GO:0005657replication fork IBA--

    TP53 for ontologies           About GeneDecksing



    TP53 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TP53
    R&D Systems Antibodies for TP53 (p53)
    Cell Signaling Technology (CST) Antibodies for TP53  (p53)
    OriGene Antibodies for TP53
    OriGene Custom Antibody Services for TP53
    GenScript Superior Antibodies for TP53
    Novus Biologicals TP53 Antibodies
    Abcam antibodies for TP53
    Cloud-Clone Corp. Antibodies for TP53 
    ThermoFisher Antibody for TP53
    LSBio Antibodies in human, mouse, rat for TP53 

    Assay Products for TP53: 
    EMD Millipore Kits and Assays for the Analysis of TP53
    OriGene Custom Assay Services for TP53
    R&D Systems ELISAs for TP53 (p53)         (see all)
    GenScript Custom Assay Services for TP53
    Cell Signaling Technology (CST) Sandwich ELISA Kits for TP53 (p53)
    Enzo Life Sciences assays for TP53
    Cloud-Clone Corp. ELISAs for TP53 
    Cloud-Clone Corp. CLIAs for TP53


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR011615 p53_DNA-bd
     IPR010991 p53_tetrameristn
     IPR012346 p53/RUNT-type_TF_DNA-bd
     IPR002117 p53_tumour_suppressor
     IPR008967 p53-like_TF_DNA-bd

    Graphical View of Domain Structure for InterPro Entry P04637

    ProtoNet protein and cluster: P04637

    1 Blocks protein domain: IPB010991 p53

    UniProtKB/Swiss-Prot: P53_HUMAN, P04637
    Domain: The nuclear export signal acts as a transcriptional repression domain. The TADI and TADII motifs (residues
    17 to 25 and 48 to 56) correspond both to 9aaTAD motifs which are transactivation domains present in a large
    number of yeast and animal transcription factors
    Similarity: Belongs to the p53 family


    TP53 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P53_HUMAN, P04637
    Function: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the
    physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to
    negatively regulate cell division by controlling a set of genes required for this process. One of the activated
    genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation
    of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF
    is involved in activating oxidative stress-induced necrosis; the function is largely independent of
    transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1.
    LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to
    effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when
    associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the
    transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses
    transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform
    1-mediated apoptosis
    Induction: Up-regulated in response to DNA damage. Isoform 2 is not induced in tumor cells in response to stress

         Genatlas biochemistry entry for TP53:
    tumor suppressor protein p53 required for G1 growth arrest by WAF1 (CDKN1A),following DNA damage or induction of
    apoptosis,also regulating a G2 checkpoint through cyclin B1,transcriptional activator through acetylation of
    transactivation site by CREBBP binding MDM2 resulting in transcriptional silencing and ubiquitin/proteasome
    dependent degradation of p53,activated by conjugation to UBL1 (SUMO1),putative up-regulated c-MYC target
    gene,putative teratologic suppressor gene and modulator of TFIIH (GTF2H),associated in nucleotide excision
    repair,activated by ATM in association with 14.3.3 proteins (YWHA*),tumor suppressor gene (see TSG17A),mutated in
    cancers such as pancreas and endometrial carcinomas,in Barrett's adenocarcinoma (and esophageal squamous cell
    carcinoma),in hepatocellular carcinoma with poor prognosis

         Gene Ontology (GO): 5/28 molecular function terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0001085RNA polymerase II transcription factor binding IPI18549481
    GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA17146433
    GO:0002020protease binding IPI11923872
    GO:0002039p53 binding IBA--
         
    TP53 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for TP53:
     Decreased viability of wild-ty  Enable proliferation in B-Raf   Increased cell death HMECs cel  Increased resistance to MDM2 i 

         15/27 MGI mutant phenotypes (inferred from 65 alleles(MGI details for Trp53) (see all 27):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    TP53 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TP53: Trp53tm1Mlh Trp53tm3Wahl Trp53tm5Wahl Trp53tm2Wahl Trp53tm1Tyj Trp53tm1Mok
                                                         Trp53tm1.1Brn Trp53tm1Brd Trp53tm1Sia

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TP53 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TP53

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TP53 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TP53 

    1911 SABiosciences Target genes for TP53 (see first 10):
    AATF ABCC3 ABCC6P2 ABCD1 ABCF1 ABHD12 ABHD15 ABHD4 ABHD8 ABTB2
    ACP1 ACRBP ACSM3 ACTB ACTG1 ACTN3 ACTR2 ACTR5 ADAMTS9 ADARB1
    ADCYAP1R1 ADH1B ADPRHL1 ADRB2 ADSSL1 AGA AGAP3 AGAP7 AGBL1 AGPAT9
    AGRN AIF1L AIPL1 AK1 AKAP8 AKR1C1 AKR1C3 AKTIP ALDH2 ALDH5A1
    ALG1L ALK ALMS1P ALOX12P2 ALOX5 AMDHD2 AMH AMPH ANK2 ANKDD1A
    ANKFY1 ANKK1 ANKRD13B ANKRD13D ANKRD23 ANKRD33B ANTXR1 ANTXR2 ANXA13 ANXA2P3
    AOC2 AOC3 AP1M1 AP1M2 APBA2 APBB3 APC2 APH1B APLP1 APLP2
    APOF AQP2 AQP5 AQP6 ARG1 ARHGAP12 ARHGAP29 ARHGAP30 ARHGEF2 ARHGEF3
    ARHGEF5 ARHGEF7 ARID1A ARID3A ARID3C ARL1 ARL2 ARL5B ARL6IP5 ARSG
    ARSH ART3 ASAH2 ASMT ASPSCR1 ASTL ASXL2 ATAD2 ATG2A ATG5
    ATOH1 ATOX1 ATP13A2 ATP1A1 ATP2A1 ATP5E ATP5SL ATP6V0C ATP7B ATP8B3
    ATRIP AZI1 B3GALT4 B3GALT5 B3GNT9 B4GALNT1 BACE1 BACE2 BAG1 BAIAP2L1
    BAK1 BANP BARD1 BCAM BCAN BCL2L12 BCL7C BCR BECN1 BEND3
    BGLAP BHLHE40 BIRC2 BLM BLNK BLZF1 BMP1 BMP6 BMP8A BNC1
    BNIP3 BOC BOLA3 BRAF BRD4 BTG2 BTG3 BTLA BTN1A1 BTN2A1
    BTN2A2 BTN3A1 BTN3A3 BUB3 C10orf10 C10orf2 C10orf99 C11orf1 C11orf85 C12orf49
    C12orf76 C16orf78 C16orf87 C16orf89 C17orf72 C17orf82 C17orf89 C17orf99 C18orf56 C19orf24
    C19orf35 C19orf38 C19orf67 C1orf147 C1orf204 C1orf74 C21orf33 C2CD2L C2orf66 C2orf70
    C3orf27 C3orf62 C4B C4orf36 C5orf24 C5orf48 C6orf106 C7orf41 C7orf49 C8G
    C9orf153 C9orf78 CA5A CA5B CA7 CABLES2 CACNA1E CADM1 CALML5 CALR
    CAPN2 CARTPT CASKIN1 CASP10 CASP12 CASP14 CAST CBLN4 CBX3 CC2D1B
    CCDC11 CCDC120 CCDC127 CCDC148 CCDC157 CCDC42 CCDC51 CCDC59 CCDC61 CCDC85B
    CCL18 CCL19 CCL21 CCL27 CCL28 CCNB1 CCNK CCNYL2 CCR5 CCT6A
    CCT6B CD200 CD27 CD2BP2 CD38 CD3E CD3EAP CD68 CD7 CD79A
    CD8A CDAN1 CDC123 CDC20 CDC37L1 CDC42EP2 CDCA5 CDH1 CDH13 CDH19
    CDH22 CDIPT CDK5 CDK5R1 CDK5RAP3 CDK9 CDKN2B CDKN2D CDT1 CEACAM6
    CEBPZ CELSR3 CEND1 CEP164 CEP78 CETN1 CETP CFI CFL1 CFLAR
    CGB7 CGB8 CHAC1 CHAD CHCHD10 CHD9 CHEK1 CHID1 CHMP6 CHRFAM7A
    CHRNA10 CHRNA4 CHST2 CHTF18 CIDECP CIRBP CISD1 CKMT2 CKS1B CLC
    CLCN6 CLDN17 CLEC3A CLECL1 CLIC1 CLIP1 CLK2 CLSTN2 CMTM5 CNN3
    CNNM2 CNP COG7 COG8 COL18A1 COL8A1 COMMD6 COPB1 COPB2 COPS3
    COPS8 COQ7 CORO2A CORT COX5A COX5B COX6A1 CPN1 CPO CPSF3
    CPT1C CRCT1 CREBBP CREG1 CRNKL1 CRYGS CRYZL1 CSAG2 CSK CSN2
    CTCF CTF1 CTNNA3 CTNNB1 CTR9 CTRL CTSW CUEDC2 CUL4B CXCL9
    CXXC1 CYB5R2 CYBA CYLD CYMP CYP1A1 CYP1A2 CYP21A2 CYP27A1 CYP2C19
    CYP4F2 CYP4F22 CYTL1 DAB2IP DACT3 DAD1 DAK DAP DAPK3 DAPL1
    DAXX DAZ1 DAZ2 DAZ3 DAZ4 DAZAP2 DCBLD2 DCC DCK DCLRE1A
    DCLRE1C DCP1A DCTN3 DDA1 DDAH2 DDIT4 DDR2 DDT DDX3X DDX5
    DDX50 DDX52 DECR1 DEDD DEFB1 DEFB126 DEFB127 DES DFNA5 DGCR5
    DGKA DGKQ DHCR24 DHFR DHPS DHX30 DHX33 DHX38 DIABLO DIRC2
    DIS3 DKFZP586I1420 DLEC1 DLL4 DMBT1 DMP1 DMRTB1 DMTF1 DNAH3 DNAH8
    DNAJB1 DNAJB2 DNAJB3 DNAJC5 DNAJC7 DNALI1 DNASE1L2 DND1 DNMT3A DPAGT1
    DPEP3 DPY19L2P2 DRAP1 DRG1 DSTYK DTL DTX1 DUOX1 DUOX2 DUOXA1
    DUSP2 DUSP3 DUSP4 DUSP5 DUT DYRK2 DZIP1 E2F3 E2F4 E4F1
    EAF2 EARS2 EBP ECD EDN1 EED EEF1G EEF2 EFEMP2 EFNA2
    EFNA3 EFS EGFL6 EGFL8 EGFR EHD1 EHMT1 EI24 EID1 EID2
    EID2B EID3 EIF2AK4 EIF2B3 EIF2S1 EIF4A1 EIF4A3 EIF4E1B EIF4G1 EIF5A2
    ELF1 ELFN2 ELK4 ELMO3 ELOF1 ELOVL1 ENO2 ENSA EOMES EPB41L3
    EPC1 EPDR1 EPHA10 EPHA5 EPHB4 EPHX1 EPN3 EPOR ERAL1 ERBB4
    ERCC2 ERCC3 ERCC4 ERCC5 EREG ERF ESP33 ETAA1 ETHE1 ETS2
    EVI5 EXTL3 FAF1 FAHD1 FAM109A FAM126A FAM153C FAM157C FAM166A FAM171A2
    FAM179A FAM180A FAM19A3 FAM3A FAM41C FAM57A FAM64A FAM73B FAM83D FAM83E
    FAM83H FAM89B FAM8A1 FAM90A1 FAM92A1 FANCC FANCD2 FARSA FASTK FBF1
    FBXL15 FBXL18 FBXL8 FBXO11 FBXO5 FBXW5 FBXW8 FBXW9 FCGR1A FCGR2A
    FCN2 FEM1B FER FERD3L FGF17 FGGY FGR FH FHOD3 FIBP
    FICD FIGF FIZ1 FLCN FLII FLJ26850 FLJ30403 FLJ37453 FLJ42627 FLJ46010
    FMNL2 FMO2 FMO6P FNBP1L FOSL1 FOSL2 FOXD4L1 FOXD4L2 FOXD4L3 FOXE1
    FOXF1 FOXH1 FOXO3B FOXR1 FPGS FPGT FREM2 FSCN1 FSCN2 FTSJ1
    FUK FUT11 FUT2 FXYD3 G3BP1 G6PD GABRA2 GABRA3 GABRQ GADD45G
    GADD45GIP1 GAL GALM GALNT10 GALNT6 GALNT9 GALT GAPDH GAR1 GAS6
    GAS7 GCA GCHFR GCM2 GCNT2 GCNT3 GCOM1 GDA GFER GGNBP1
    GIMAP1 GIMAP5 GJB1 GLA GLI1 GLIPR1 GLIPR2 GLO1 GLTSCR2 GLUD2
    GLYAT GMIP GML GMNN GMPS GNA11 GNAI1 GNAT3 GNB2L1 GNL1
    GNPTAB GOT1L1 GPLD1 GPNMB GPR111 GPR12 GPR132 GPR133 GPR173 GPR176
    GPR18 GPR84 GPR88 GPRC5A GPRIN2 GPSM2 GPT GPX1 GPX2 GPX4
    GRB2 GREM1 GRIA2 GRIA3 GRID2IP GRIN2D GSK3A GSPT1 GSR GSTO2
    GSTP1 GSTT2 GSTTP2 GTF2A1L GTF2H4 GUK1 GZMH H19 H2AFX HABP4
    HAGH HAPLN2 HARS2 HAS1 HCG18 HCK HCN3 HDAC8 HEG1 HELQ
    HERC2 HERC3 HES4 HEXA HEXDC HEY1 HIATL2 HLA-DRB1 HLA-J HMOX1
    HMX2 HMX3 HN1 HNF1A HNRNPA2B1 HNRNPA3P1 HNRNPD HNRNPH2 HNRNPUL1 HOOK2
    HOXA10 HOXA11 HOXA13 HOXA6 HOXA7 HOXA9 HOXB13 HPRT1 HR HRG
    HRK HS3ST6 HSBP1 HSD17B10 HSD17B13 HSD17B4 HSF4 HSP90AA1 HSPA14 HSPA2
    HSPA6 HSPA7 HSPBAP1 HSPE1 HTR3C HYOU1 ID2 IDUA IFNGR1 IGF2
    IGFBP1 IKBKB IKBKG IL11RA IL17C IL17RD IL1RAPL1 IL1RL1 IL25 IL2RA
    IL7 IL9R IMP3 INE1 INGX INHA INHBE INO80B INSR INSRR
    INTS6 INTS7 INTS8 IP6K3 IPMK IQCB1 IQCE IQCF3 IREB2 IRF3
    IRF4 IRF5 IRF6 IRX4 ISG15 ITCH ITGA6 ITGAD ITGB1BP1 ITPKB
    ITSN1 IWS1 JAG1 JPH1 JSRP1 JUP KANK2 KCNA6 KCNA7 KCNK7
    KCNN4 KCNQ4 KCNT1 KCP KCTD21 KDELR1 KIAA0895L KIAA0947 KIAA1279 KIAA1755
    KIAA1919 KIF17 KIF18A KIF22 KIFC3 KIR2DS4 KIR3DL2 KIRREL2 KISS1R KIT
    KL KLF13 KLF5 KLF6 KLHDC9 KLHL14 KLK14 KMO KPNA3 KPNA5
    KRI1 KRT1 KRT13 KRT15 KRT17 KRT3 KRT35 KRT36 KRT5 KRT7
    KRT74 KRT76 KRT77 KRT84 LAMC3 LAMP3 LATS1 LATS2 LCE1B LCE1C
    LCE1D LCE5A LCN10 LCN12 LCN6 LDHD LETM1 LETMD1 LEUTX LGALS1
    LGALS7 LGALS7B LGI3 LHX1 LIG3 LIN37 LINGO4 LIPE LMBR1L LMCD1
    LNP1 LOC100128035 LOC100128430 LOC100129055 LOC100129060 LOC100129637 LOC100130100 LOC100130238 LOC100130938 LOC100131257
    LOC100131582 LOC100132272 LOC100192426 LOC100271832 LOC100271836 LOC100286925 LOC100286986 LOC100287294 LOC100287329 LOC100287525
    LOC100287951 LOC100288123 LOC100288181 LOC100288482 LOC100288656 LOC100288802 LOC100288869 LOC100288893 LOC100289283 LOC113230
    LOC128322 LOC143666 LOC151009 LOC220077 LOC221122 LOC284577 LOC284889 LOC286177 LOC342293 LOC344887
    LOC388152 LOC388955 LOC391578 LOC392196 LOC400499 LOC401052 LOC407835 LOC439951 LOC440031 LOC440300
    LOC553137 LOC595101 LOC642423 LOC642515 LOC642633 LOC642635 LOC642648 LOC643043 LOC644172 LOC646938
    LOC646999 LOC653486 LOC723805 LOC728463 LOC728503 LOC728537 LOC728989 LOC729275 LOC729324 LOC729654
    LOC729681 LOC729856 LOC729941 LOC729970 LOC730974 LOC93463 LONRF2 LOXHD1 LPAR2 LPO
    LPP LRRC14 LRRC26 LRRC3 LRRC4 LRRC48 LRRC66 LRRC8B LRWD1 LSM11
    LSR LSS LST1 LTA LTB LTBP2 LY6G6C LYPD1 LYPD2 LYPD4
    LYPD5 LYST LYZ LZTS1 MAGEA12 MAGEA2 MAGEA2B MAGEA3 MAGEA4 MAGEA6
    MAGEA8 MAGEC1 MAGEC3 MAGED2 MAGEH1 MANBA MAP3K1 MAP3K5 MAP3K6 MAP4K2
    MAPK11 MAPK12 MAPK8IP1 MAPKAPK5 MARVELD3 MAS1 MATN2 MAZ MBD1 MBD2
    MBL2 MCAM MCCC2 MCHR1 MCM2 MCM4 MCM5 MCM8 MCTS1 MDC1
    MDGA2 ME1 MED20 MED24 MED28 MED29 MEIG1 MET MEX3A MEX3D
    MFAP2 MFSD3 MGC34034 MGC57346 MIB1 MIF MKS1 MLANA MMP11 MMP23B
    MMP26 MMP7 MNT MOGAT3 MON2 MORF4L1 MORN1 MPDU1 MPP2 MPV17
    MRGPRX2 MRPL13 MRPL18 MRPL34 MRPL46 MRPS11 MRPS18C MRPS24 MRTO4 MSH3
    MSH5 MSI1 MSLN MSN MSRA MSX1 MSX2P1 MT1A MT1DP MT1M
    MT2A MT3 MTA1 MTA2 MTBP MTERFD3 MTF1 MTHFD2 MTHFD2L MTHFR
    MUC2 MUC5AC MUC5B MUC6 MUM1 MVD MVP MYADML MYADML2 MYBL2
    MYCN MYCNOS MYL3 MYL9 MYLK MYLPF MYNN MYO1H MYO6 MYO7B
    MYOG NACA2 NAE1 NALCN NANOG NARFL NAT2 NAT8 NBL1 NBN
    NBPF11 NBPF3 NBR1 NCF1 NCOA6 NDEL1 NDNL2 NDST1 NDUFAF1 NDUFB11
    NDUFS8 NDUFV2 NEFH NFKB2 NFX1 NFXL1 NFYA NHLRC1 NHLRC2 NHS
    NHSL1 NINJ1 NIP7 NIT1 NKAP NKAPL NKD2 NKIRAS2 NKX2-4 NKX3-1
    NLE1 NMBR NMD3 NME7 NOD1 NOL12 NOL3 NOMO1 NOMO2 NOSIP
    NOTCH4 NOTUM NOVA2 NOX4 NPBWR2 NPFF NPFFR1 NPHS1 NPY1R NPY6R
    NQO1 NR2C1 NRXN3 NSUN6 NT5C NT5M NTF4 NTHL1 NTN1 NTN5
    NTNG1 NTRK1 NUCKS1 NUDT16 NUDT5 NUMBL NUP93 NXF4 NXT1 OAZ1
    OBSL1 OCA2 OCM ODF3 ODF3L2 OGDH OPA1 OPN1MW OPN1SW OR10K1
    OR13C9 OR1E1 OR1N2 OR2A9P OR2M2 OR4C46 OR4D1 OR4D2 OR51A2 OR51I1
    OR51I2 OR51Q1 OR52B6 OR52H1 OR6F1 ORAI1 OTUB2 OXER1 P2RX2 P2RX6
    PABPC3 PACS2 PAICS PAK1 PANX3 PAQR6 PARD6G PARVG PBX4 PBXIP1
    PC PCDH11X PCDH11Y PCDHB1 PDC PDCD1LG2 PDCD5 PDCL3 PDE6A PDE8A
    PDF PDK1 PDS5B PDXP PEAR1 PECR PEMT PER1 PERP PES1
    PEX14 PFDN2 PFDN6 PFN2 PFN4 PGBD1 PGC PGF PGP PHC2
    PHEX PHF21B PHLDB2 PI3 PIBF1 PIF1 PIGV PIK3C3 PIM3 PIP
    PISD PKD1P1 PKP4 PLA2G10 PLCB2 PLCD1 PLD4 PLEKHA7 PLEKHG1 PLEKHJ1
    PLEKHO2 PLOD3 PLSCR5 PLXNA2 PLXNB1 PMP22 PMPCA PMPCB PNKP PNLDC1
    PNLIPRP2 PNO1 PNPLA2 PODXL POLK POLR2A POLR2E POLR2G POLR3K POMT1
    POMZP3 PON1 PORCN POU1F1 POU4F2 PPAPDC2 PPAT PPFIBP1 PPM1A PPM1F
    PPOX PPP1CA PPP1R12C PPP1R13B PPP1R13L PPP1R16A PPP2R5A PPP2R5B PPP3CB PPP4R1
    PPY PRAMEF10 PRAMEF13 PRAMEF22 PRAMEF25 PRAMEF4 PRAMEF6 PRAMEF8 PRDM1 PRDM7
    PRICKLE4 PRINS PRKCD PRKDC PRMT1 PRNP PROM1 PROM2 PROP1 PRPS1
    PRR12 PRR15 PRRG2 PRRT1 PRRT2 PRX PSD2 PSEN2 PSENEN PSMA1
    PSMB10 PSMC4 PSMD11 PSMD2 PSMD5 PSME3 PSME4 PSMG3 PSPH PSRC1
    PTCD3 PTCRA PTH1R PTMA PTMS PTPN9 PTPRM PUS10 PVR PVRL4
    PVT1 PYCARD PYGO2 QPRT QSOX2 R3HDM2 RAB11B RAB27B RAB33B RAB35
    RAB39B RAB40AL RAB6B RAD23A RAD23B RAD50 RAD51 RAD52 RAD54L2 RAD9A
    RALA RALBP1 RANBP2 RANGAP1 RAPGEF5 RAPGEFL1 RARA RARRES3 RASD1 RASGRF2
    RASGRP4 RASSF5 RBBP4 RBL1 RBM10 RBM17 RBM19 RBP1 RBX1 REEP1
    RER1 RETNLB RFT1 RGMA RGS12 RHBDL1 RHBDL3 RHEB RHOC RHOF
    RHOH RHOT2 RIBC1 RIF1 RIMBP3C RIMS1 RIPK1 RNF19A RNF207 RNF25
    RNF5 RNPS1 ROM1 ROS1 RPL10 RPL11 RPL13AP20 RPL22 RPL23AP32 RPL29
    RPL30 RPLP2 RPP21 RPP25 RPP38 RPS13 RPS15 RPS16 RPS18 RPS19
    RPS20 RPS4X RPS6KB2 RRAS RRH RRM1 RSAD1 RSF1 RSPH1 RTF1
    RTKN RTP3 RUSC2 RXFP2 RYR1 S100A2 S100Z SACS SAMD1 SAMD10
    SAV1 SCAF1 SCGB1D2 SCGB2A2 SCN3B SCN4A SCN8A SCNN1B SDCBP SDCCAG3
    SDF2 SDHA SDK2 SDR9C7 SEMA3F SEMA4D SEMA4G SENP3 SEPHS1 SEPT1
    SERPINA11 SERPINA9 SERPINB5 SERPINF2 SERTAD1 SERTAD3 SESN2 SETD3 SETD8 SEZ6L
    SF3A1 SF3A2 SFPQ SFRP4 SFTPC SGCB SGK1 SH2D2A SH2D3C SH2D4A
    SH2D5 SH3BP1 SH3GLB2 SH3YL1 SHANK2 SHC2 SHF SHISA4 SIGMAR1 SLBP
    SLC10A3 SLC10A6 SLC11A2 SLC12A9 SLC15A4 SLC17A5 SLC20A1 SLC22A11 SLC22A14 SLC24A3
    SLC25A22 SLC26A1 SLC26A2 SLC26A3 SLC2A7 SLC33A1 SLC34A1 SLC35A4 SLC37A1 SLC38A3
    SLC38A5 SLC38A7 SLC4A11 SLC4A2 SLC5A1 SLC5A11 SLC5A4 SLC5A7 SLC6A13 SLC6A18
    SLC6A19 SLC9A1 SLC9A8 SLCO4A1 SLCO5A1 SLMO2 SLURP1 SMAP2 SMARCB1 SMARCC1
    SMC1A SMEK2 SMG1 SMG7 SMOC1 SMUG1 SNAP25 SNAPC4 SNCAIP SNCB
    SNF8 SNHG6 SNIP1 SNN SNORA11 SNORA15 SNORA20 SNORA29 SNORA31 SNORA35
    SNORA37 SNORA48 SNORA52 SNORA67 SNORA70 SNORA72 SNORD10 SNORD14A SNORD14B SNORD23
    SNORD37 SNORD3B-1 SNORD41 SNORD54 SNORD62A SNORD62B SNORD84 SNORD87 SNORD95 SNORD96A
    SNORD98 SNRNP25 SNRPB2 SNTB2 SNUPN SNX12 SNX15 SNX2 SNX33 SOAT1
    SOD1 SOHLH1 SP2 SPACA3 SPACA4 SPAM1 SPATA18 SPATA2 SPATA3 SPDYE2
    SPEG SPEN SPG20 SPHK2 SPN SPPL3 SPRR2A SPRR2B SPTBN1 SPTBN5
    SRA1 SRGAP3 SRL SRMS SRP14P1 SRP54 SRRM2 SRXN1 SSB SSTR3
    SSTR4 SSTR5 SSX2 ST3GAL2 ST3GAL4 ST6GALNAC2 ST8SIA3 STAG1 STAT2 STATH
    STEAP3 STK11 STK25 STK36 STK40 STRAP STRN STUB1 SUMF2 SUMO3
    SUPT4H1 SUPV3L1 SUSD5 SUV39H1 SYCP2L SYK SYNGR2 SYNGR3 SYNGR4 SYNJ2BP
    SYNPO TACC3 TAF6L TAOK2 TAPBP TAPBPL TAS2R10 TAS2R8 TAS2R9 TBC1D10B
    TBC1D10C TBC1D13 TBC1D17 TBCEL TBL2 TBRG1 TBX15 TBX2 TCEAL1 TCEAL3
    TCEAL4 TCEAL5 TCEAL6 TCEAL8 TCEB2 TCERG1 TCIRG1 TCL1B TCN2 TCP1
    TDH TDRKH TEF TEKT4 TERC TERT TEX101 TFAP4 TFE3 TGFA
    TGFB1 TGFB2 THAP7 THG1L THOC1 THOC5 THUMPD1 THY1 TIMM13 TIMM8A
    TIMM9 TIMP2 TJP2 TKT TLE2 TLE6 TMCC2 TMED1 TMED6 TMEM129
    TMEM130 TMEM132D TMEM143 TMEM159 TMEM161A TMEM171 TMEM183A TMEM183B TMEM219 TMEM222
    TMEM35 TMEM37 TMEM41B TMPRSS11D TMSB10 TNF TNFRSF13C TNFRSF18 TNFRSF25 TNFRSF4
    TNFRSF8 TNIP1 TNXA TOM1L2 TOMM20L TOMM70A TOPBP1 TOR1A TP53BP2 TP53I11
    TP53I13 TP53INP1 TP53INP2 TP73 TPBG TPK1 TPRG1L TPRXL TPTE TRA2B
    TRADD TRAF2 TRAF3 TRAFD1 TRAM1L1 TRDMT1 TREM2 TREML1 TRERF1 TREX1
    TRIB1 TRIM17 TRIM22 TRIM25 TRIM37 TRIM47 TRIM5 TRIM72 TRIT1 TRMT6
    TRRAP TSPAN17 TSPY1 TSPYL6 TTLL11 TTLL12 TTLL8 TUBA1B TUBA8 TUBB
    TUBB8 TUFT1 TUG1 TUT1 TWIST1 TWISTNB TXNDC11 TXNDC15 TXNIP TXNL4B
    TYMS TYR U2AF1L4 UBA1 UBA3 UBE2D1 UBE2D2 UBE2D3 UBE2G2 UBE2L3
    UBFD1 UBL4A UBTD1 UBTFL1 UBTFL2 UBTFL6 UBXN8 UCHL1 UCHL3 UCK1
    UFC1 UGT1A1 UGT1A4 UGT1A5 UGT1A6 UHMK1 UNC45B UNC5B UNG UPB1
    UPK2 UQCRC2 UQCRH UQCRHL USF2 USP11 USP16 USP17L4 USP17L8 USP20
    USP21 USP28 USP29 USP35 USP4 USP48 USP6NL USPL1 UTP14C VAMP2
    VAPA VEGFC VHL VIM VPS11 VPS4B VPS52 VPS53 VRK1 VRK2
    VSTM2L VTI1B WBP1 WBP2 WDR46 WDR61 WDR92 WEE1 WFDC6 WHSC1
    WIBG WIPI2 WNT3 WNT4 WNT8A WNT9B XAGE1A XAGE1B XAGE1C XAGE1E
    XDH XKR5 XPR1 XRCC3 XRCC5 YAP1 YEATS4 ZBTB25 ZBTB3 ZBTB33
    ZBTB8OS ZC3H12C ZDHHC12 ZDHHC24 ZFP28 ZFPL1 ZFYVE21 ZKSCAN4 ZMYM3 ZNF107
    ZNF117 ZNF135 ZNF142 ZNF165 ZNF18 ZNF217 ZNF22 ZNF235 ZNF267 ZNF331
    ZNF347 ZNF367 ZNF415 ZNF43 ZNF48 ZNF524 ZNF541 ZNF546 ZNF558 ZNF579
    ZNF593 ZNF594 ZNF626 ZNF676 ZNF704 ZNF730 ZNF747 ZNF76 ZNF768 ZNF77
    ZNF79 ZNF821 ZNF830 ZNF839 ZNF846 ZNF852 ZNHIT1 ZPBP ZSCAN2 ZUFSP
    ZYX

    miRNA
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    miRTarBase miRNAs that target TP53:
    hsa-mir-1285 (MIRT005474), hsa-mir-16 (MIRT005764), hsa-mir-125a-5p (MIRT004071), hsa-mir-25 (MIRT005417), hsa-mir-221 (MIRT005785), hsa-mir-15a (MIRT005763), hsa-mir-612 (MIRT005476), hsa-mir-222 (MIRT005786), hsa-mir-125b (MIRT000535), hsa-mir-30d (MIRT005418)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TP53
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate TP53 (see all 17):
    hsa-miR-576-3p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-98 hsa-miR-22
    SwitchGear 3'UTR luciferase reporter plasmidTP53 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TP53 About   (see all 105)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glioma
    Glioma0.51
    Prostate cancer0.39
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    Melanoma0.43
    Bladder cancer0.31
    2Endometrial cancer
    Endometrial cancer0.45
    Colorectal cancer0.42
    Signal transduction PTEN pathway0.45
    3Development HGF signaling pathway
    Development Neurotrophin family signaling0.45
    Neurotrophin signaling pathway0.36
    Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    4Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    5MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/16 EMD Millipore Pathways for TP53 (see all 16)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Proteolysis Putative SUMO-1 pathway
    Immune response MIF in innate immunity response
    DNA damage DNA-damage-induced responses
    DNA damage Role of SUMO in p53 regulation

    2 R&D Systems Pathways for TP53
        Apoptosis Signaling Pathways
    Akt Signaling Pathway

    5/41 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TP53 (see all 41)
        Telomerase Components in Cell Signaling
    UVB-Induced MAPK Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer
    TRKA Signaling

    2 Cell Signaling Technology (CST) Pathways for TP53
        Cell Cycle / Checkpoint Control
    DNA Damage

    4 Tocris Bioscience Pathways for TP53
        Akt Pathway
    Apoptosis Pathway
    MAPK Pathway
    mTOR Pathway

    5/13 GeneGo (Thomson Reuters) Pathways for TP53 (see all 13)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Immune response MIF in innate immunity response
    Transcription P53 signaling pathway
    Development Neurotrophin family signaling
    Signal transduction AKT signaling

    5/36 BioSystems Pathways for TP53 (see all 36)
        MAPK signaling pathway
    DNA damage response
    Apoptosis
    Fluoropyrimidine Activity
    Senescence and Autophagy

    3 Sino Biological Pathways for TP53 
        EGFR Signaling Pathway
    p53 Pathway
    Death Receptor Signaling

    5/9        Reactome Pathways for TP53 (see all 9)
        Hemostasis
    Stabilization of p53
    Cell Cycle
    G1/S DNA Damage Checkpoints
    p53-Dependent G1 DNA Damage Response

    2 PharmGKB Pathways for TP53
        Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
    Fluoropyrimidine Pathway, Pharmacodynamics

    5/32         Kegg Pathways  (Kegg details for TP53) (see all 32):
        MAPK signaling pathway
    Cell cycle
    p53 signaling pathway
    PI3K-Akt signaling pathway
    Apoptosis


    TP53 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TP53

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/930 Interacting proteins for TP53 (P046371, 2, 3 ENSP000002693054) via UniProtKB, MINT, STRING, and/or I2D (see all 930)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009871, 2, 3, ENSP000004172814EBI-366083,EBI-389668 MINT-6540920 MINT-4793511 MINT-6823775 MINT-7013943 MINT-8303857 MINT-6540905 MINT-68742 MINT-8385459 MINT-56681 MINT-8374464 MINT-58468 MINT-7013791 MINT-68743 MINT-7013956 MINT-4545014 MINT-8339574 MINT-4049631 MINT-6540776 MINT-6801380 MINT-8374452 MINT-58465 MINT-7013688 MINT-7013802 MINT-4303990 MINT-8339590 MINT-6665330 MINT-4793467 MINT-8380636 MINT-4049616 MINT-4054304 MINT-7905142 MINT-8385480 MINT-7013780 MINT-6540889 MINT-8385531 MINT-8385552 MINT-8385886 MINT-8388795 MINT-8415355 MINT-6540807 MINT-8391984 MINT-7905326 MINT-6540796 I2D: score=12 STRING: ENSP00000417281
    HNRNPUL1Q9BUJ21, 2, 3, ENSP000003758634EBI-366083,EBI-1018153 MINT-58678 MINT-58677 MINT-58673 MINT-58674 MINT-58676 MINT-58675 MINT-8415355 MINT-58672 I2D: score=3 STRING: ENSP00000375863
    UBCP0CG482, 3, ENSP000003448184MINT-7220023 MINT-4051326 MINT-4304004 MINT-4054804 MINT-4304143 MINT-6801380 MINT-6615153 MINT-6541035 MINT-7299234 MINT-7298704 MINT-6799774 MINT-7013815 MINT-4052207 MINT-7219995 MINT-5114741 I2D: score=5 STRING: ENSP00000344818
    ENSG00000237724P081073, ENSP000004063594I2D: score=3 STRING: ENSP00000406359
    HSPA1AP081073, ENSP000003648024I2D: score=3 STRING: ENSP00000364802
    About this table

    Gene Ontology (GO): 5/96 biological process terms (GO ID links to tree view) (see all 96):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IEA--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS19749791
    GO:0000733DNA strand renaturation IDA8183576
    GO:0001701in utero embryonic development IEA--
    GO:0001756somitogenesis IEA--

    TP53 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TP53 for compounds           About GeneDecksing

    EMD Millipore small molecules for TP53:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for TP53

    Compounds for TP53 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PRIMA-1METRestores mutant p53 activity[5291-32-7]
    Pifithrin-alpha hydrobromidep53 inhibitor. Also aryl hydrocarbon receptor agonist[63208-82-2]
    RITAMDM2-p53 interaction inhibitor[213261-59-7]
    Cyclic Pifithrin-alpha hydrobromidep53 inhibitor[511296-88-1]
    Pifithrin-muInhibitor of p53-mitochondrial binding[64984-31-2]

    1 DrugBank Compound for TP53    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine-- --target--10592235

    10/117 Novoseek inferred chemical compound relationships for TP53 gene (see all 117)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraffin 76.9 382 8640471 (4), 7726729 (4), 8434637 (4), 15363320 (4) (see all 99)
    cisplatin 74 1151 12492119 (9), 9811465 (8), 18064040 (7), 14513366 (7) (see all 99)
    noxa 72.7 89 17216584 (4), 17653088 (3), 20160496 (3), 15598651 (3) (see all 52)
    hpvs 71.4 72 20200430 (2), 11002226 (2), 8726818 (2), 9714244 (1) (see all 50)
    estrogen 71 898 14595509 (6), 9744308 (5), 10719737 (4), 15312749 (4) (see all 99)
    progesterone 69.1 712 12416559 (6), 14595509 (5), 9635673 (5), 9744308 (5) (see all 99)
    doxorubicin 67.6 464 15116093 (6), 18263706 (6), 8988061 (5), 11745235 (5) (see all 99)
    aflatoxin b1 63.4 212 16280384 (6), 8921985 (5), 19524575 (5), 1310637 (5) (see all 90)
    5fluorouracil 63.2 456 17634554 (12), 11044365 (7), 14703431 (7), 19810096 (6) (see all 99)
    camptothecin 63.1 172 10536167 (6), 9815856 (5), 19445707 (4), 17709397 (3) (see all 75)

    5 PharmGKB related drug/compound annotations for TP53 gene    About this table
    Drug/compound PharmGKB Annotation
    antineoplastic agentsCA  
    cisplatinCA  
    cyclophosphamideCA  
    fluorouracilCA  
    paclitaxelCA  

    Search CenterWatch for drugs/clinical trials and news about TP53 / P53

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for TP53 gene (15 alternative transcripts): 
    NM_000546.5  NM_001126112.2  NM_001126113.2  NM_001126114.2  NM_001126115.1  NM_001126116.1  NM_001126117.1  NM_001126118.1  
    NM_001276695.1  NM_001276696.1  NM_001276697.1  NM_001276698.1  NM_001276699.1  NM_001276760.1  NM_001276761.1  

    Unigene Clusters for TP53:

    Tumor protein p53
    Hs.437460  [show with all ESTs], Hs.740601  [show with all ESTs]
    Unigene Representative Sequences: NM_001126114, BM469215
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413465(uc002gig.1) ENST00000359597(uc002gih.3) ENST00000504290(uc010cnf.1)
    ENST00000510385(uc010cng.1) ENST00000504937(uc010cne.1 uc002gii.1)
    ENST00000269305(uc002gim.2 uc002gij.2 uc002gin.2 uc002gio.2 uc010cnk.1)
    ENST00000455263(uc010cnh.1) ENST00000420246(uc010cni.1) ENST00000445888
    ENST00000576024 ENST00000509690(uc010cnj.1) ENST00000514944 ENST00000574684
    ENST00000505014(uc010vug.2) ENST00000508793 ENST00000604348 ENST00000503591

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate TP53 (see all 17):
    hsa-miR-576-3p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-98 hsa-miR-22
    SwitchGear 3'UTR luciferase reporter plasmidTP53 3' UTR sequence
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      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP53

    Additional mRNA sequence: 

    AY627884.1 DQ648883.1 

    17 DOTS entries:

    DT.92469229  DT.100788714  DT.120961435  DT.100788713  DT.75152217  DT.40283865  DT.95274968  DT.100712946 
    DT.120961349  DT.100788719  DT.40120491  DT.120961395  DT.100788715  DT.92010563  DT.120961350  DT.120961391 
    DT.120961408 

    24/112 AceView cDNA sequences (see all 112):

    CR608294 BU673953 CK904490 BU174921 X60018 S66666 BQ066009 AI539544 
    AA379547 BE886147 AA662570 BX952582 X60012 AA291539 X02469 CR624912 
    CA432254 AY627884 BQ057682 AW865736 X60016 AA358870 BM457966 BV190717 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TP53 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
    SP1:                                -                             -           -     -                           
    SP2:                                                              -                                             
    SP3:                                                              -           -                                 
    SP4:                                                              -           -     -                           
    SP5:                                                                          -     -                           


    ECgene alternative splicing isoforms for TP53

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TP53 expression in normal human tissues (normalized intensities)      TP53 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGAGCCGC
    TP53 Expression
    About this image


    TP53 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 2 entries
             oral mucosa ; squamous epithelial cells   
             mouth   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Peripheral blood-derived endothelial progenitor cells
             huvec   
     
     Hair
             Primary Hair Placode Cells Hair Follicle
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Intermediate Keratinocytes Embryonic Epidermis
     
     Epithelium (Uncategorized)    fully expand to see all 2 entries
             oral mucosa ; squamous epithelial cells   

    See TP53 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TP53

    SOURCE GeneReport for Unigene clusters: Hs.437460 Hs.740601

    UniProtKB/Swiss-Prot: P53_HUMAN, P04637
    Tissue specificity: Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent
    manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal
    brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung,
    spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is
    not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow,
    testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain,
    heart, lung, fetal liver, salivary gland, breast or intestine

        SABiosciences Expression via Pathway-Focused PCR Arrays including TP53 (see all 37): 
              Lung Cancer in human mouse rat
              Lymphoma in human mouse rat
              Prostate Cancer in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

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    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TP53
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TP53 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trp531 , 5 transformation related protein 531, 5 80.62(n)1
    78.55(a)1
      11 (42.83 cM)5
    220591  NM_011640.31  NP_035770.21 
     695803595 
    lizard
    (Anolis carolinensis)
    Reptilia TP536
    tumor protein p53
    47(a)
    1 ↔ 1
    AAWZ02038700(4261-10723)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.209432 Xenopus laevis transcribed sequence with weak similarity to protein spP04637 (H.sapiens) P53_HUMAN Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13) less 78.01(n)    BU152764.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tp532 tumor protein p53 74.13(n)   30590  AF365873.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta p536
    p53
    13(a)
    1 → many
    3R(18875379-18879804)


    ENSEMBL Gene Tree for TP53 (if available)
    TreeFam Gene Tree for TP53 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TP53 gene
    TP732  TP632  
    3 SIMAP similar genes for TP53 using alignment to 88 protein entries:     P53_HUMAN (see all proteins):
    p53    TP73    TP63

    TP53 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2063 SNPs in TP53 are shown (see all 2063)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0446074
    Sporadic cancers4--see VAR_0446072 V M mis40--------
    VAR_0446314
    Sporadic cancers4--see VAR_0446312 A V mis40--------
    VAR_0455164
    A sporadic cancer4--see VAR_0455162 D Y mis40--------
    VAR_0454394
    A sporadic cancer4--see VAR_0454392 H R mis40--------
    VAR_0450104
    A familial cancer not matching LFS4--see VAR_0450102 V E mis40--------
    VAR_0455494
    A sporadic cancer4--see VAR_0455492 A G mis40--------
    VAR_0445894
    A sporadic cancer4--see VAR_0445892 A T mis40--------
    VAR_0457924
    A sporadic cancer4--see VAR_0457922 C T mis40--------
    VAR_0455714
    A sporadic cancer4--see VAR_0455712 S T mis40--------
    VAR_0448244
    Sporadic cancers4--see VAR_0448242 P T mis40--------

    HapMap Linkage Disequilibrium report for TP53 (7565097 - 7590863 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TP53:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv457659CNV Loss19166990


    Human Gene Mutation Database (HGMD): TP53

    Locus Specific Mutation Databases (LSDB): TP53
    5/120 SABiosciences Cancer Mutation PCR Assays for TP53 (see all 120):
    Cosmic IdAA Change
    10812p.S241F
    10856p.E294*
    11089p.I195T
    10889p.H179R
    43559p.V173L
    5/22 SABiosciences Cancer Mutation PCR Arrays containing TP53 (see all 22):
    Breast Cancer
    Cancer Comprehensive Panel 384HT
    Lung Cancer
    Myelodysplastic Syndromes
    Soft Tissue Tumors
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing TP53:
    Oncogenes & Tumor Suppressor Genes 384HC
    WNT Signaling
    SeqTarget long-range PCR primers for resequencing TP53
    DNA2.0 Custom Variant and Variant Library Synthesis for TP53

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 191170OMIM information: 215500 601202 601251 605809 606579 607464 608631 609432 610185    
    OMIM disorders: 114500  151623  114550  259500  260500  607107  260350  202300  114480  
    UniProtKB/Swiss-Prot: P53_HUMAN, P04637
  • Note=TP53 is found in increased amounts in a wide variety of transformed cells. TP53 is frequently
    mutated or inactivated in about 60% of cancers. TP53 defects are found in Barrett metaplasia a condition in which
    the normally stratified squamous epithelium of the lower esophagus is replaced by a metaplastic columnar
    epithelium. The condition develops as a complication in approximately 10% of patients with chronic
    gastroesophageal reflux disease and predisposes to the development of esophageal adenocarcinoma
  • Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are
    esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease
    because it is usually not detected until it has progressed to an advanced incurable stage. Note=The disease is
    caused by mutations affecting the gene represented in this entry
  • Li-Fraumeni syndrome (LFS) [MIM:151623]: Autosomal dominant familial cancer syndrome that in its classic
    form is defined by the existence of a proband affected by a sarcoma before 45 years with a first degree relative
    affected by any tumor before 45 years and another first degree relative with any tumor before 45 years or a
    sarcoma at any age. Other clinical definitions for LFS have been proposed (PubMed:8118819 and PubMed:8718514) and
    called Li-Fraumeni like syndrome (LFL). In these families affected relatives develop a diverse set of
    malignancies at unusually early ages. Four types of cancers account for 80% of tumors occurring in TP53 germline
    mutation carriers: breast cancers, soft tissue and bone sarcomas, brain tumors (astrocytomas) and adrenocortical
    carcinomas. Less frequent tumors include choroid plexus carcinoma or papilloma before the age of 15,
    rhabdomyosarcoma before the age of 5, leukemia, Wilms tumor, malignant phyllodes tumor, colorectal and gastric
    cancers. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting
    the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.
    Note=The gene represented in this entry is involved in disease pathogenesis
  • Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form
    of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes:
    squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced
    stage and has a poor prognosis. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • Choroid plexus papilloma (CPLPA) [MIM:260500]: Slow-growing benign tumor of the choroid plexus that often
    invades the leptomeninges. In children it is usually in a lateral ventricle but in adults it is more often in the
    fourth ventricle. Hydrocephalus is common, either from obstruction or from tumor secretion of cerebrospinal
    fluid. If it undergoes malignant transformation it is called a choroid plexus carcinoma. Primary choroid plexus
    tumors are rare and usually occur in early childhood. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Adrenocortical carcinoma (ADCC) [MIM:202300]: A malignant neoplasm of the adrenal cortex and a rare
    childhood tumor. It occurs with increased frequency in patients with Beckwith-Wiedemann syndrome and Li-Fraumeni
    syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Basal cell carcinoma 7 (BCC7) [MIM:614740]: A common malignant skin neoplasm that typically appears on
    hair-bearing skin, most commonly on sun-exposed areas. It is slow growing and rarely metastasizes, but has
    potentialities for local invasion and destruction. It usually develops as a flat, firm, pale area that is small,
    raised, pink or red, translucent, shiny, and waxy, and the area may bleed following minor injury. Tumor size can
    vary from a few millimeters to several centimeters in diameter. Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry

  • 20/548 diseases for TP53 (see all 548):    About MalaCards
    li-fraumeni syndrome    adrenocortical carcinoma    cystic teratoma    ovarian cystic teratoma
    necrotizing sialometaplasia    hepadnavirus infection    breast sarcoma    immunoproliferative small intestinal disease
    multifocal osteogenic sarcoma    pancreatic serous cystadenoma    breast apocrine carcinoma    breast adenoma
    choroid plexus papilloma    eyelid neoplasm    papilloma    bladder transitional cell carcinoma
    li-fraumeni-like syndrome    small cell carcinoma of the bladder    juvenile pilocytic astrocytoma    acute myeloid leukemia, adult

    20/52 diseases from the University of Copenhagen DISEASES database for TP53 (see all 52):
    Carcinoma     Breast cancer     Li-Fraumeni syndrome     Lung cancer
    Retinoblastoma     Colorectal cancer     Malignant glioma     Ovarian cancer
    Urinary bladder cancer     Adenoma     Leukemia     Cervical cancer
    Lymphoma     Hepatocellular carcinoma     Skin cancer     Esophageal cancer
    Endometrial cancer     Melanoma     Pancreatic cancer     Prostate cancer

    TP53 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/96 Novoseek inferred disease relationships for TP53 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 93.8 24003 8777377 (10), 7901994 (9), 8007011 (9), 8324748 (8) (see all 99)
    li-fraumeni syndrome 90.7 344 1373881 (5), 17483435 (3), 10980596 (3), 10484981 (3) (see all 99)
    cancer 90.2 7050 17598983 (10), 18223686 (8), 15055300 (7), 12561442 (7) (see all 99)
    carcinoma 87.5 3357 9110348 (10), 8062281 (9), 16033093 (8), 7927312 (8) (see all 99)
    carcinoma squamous cell 86.8 1909 9127380 (8), 8826924 (7), 10445528 (6), 11255264 (6) (see all 99)
    retinoblastoma 85.1 701 10792093 (8), 9337350 (6), 11306502 (5), 8224613 (5) (see all 99)
    microsatellite instability 85 363 9731891 (6), 9716224 (5), 11290569 (5), 12612901 (5) (see all 99)
    allelic loss 83.7 407 16293976 (5), 7909153 (5), 8467510 (4), 11520271 (4) (see all 99)
    adenocarcinoma 82.7 1551 12823203 (7), 17982662 (7), 9379505 (6), 10674608 (6) (see all 99)
    breast cancer 81.9 2818 7917542 (8), 8679460 (8), 12170762 (7), 15566648 (6) (see all 99)

    GeneTests: TP53
    GeneReviews: TP53
    Genetic Association Database (GAD): TP53
    Human Genome Epidemiology (HuGE) Navigator: TP53 (1074 documents)
    Tumor Gene Database (TGDB): TP53

    Export disorders for TP53 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TP53 gene, integrated from 9 sources (see all 15307):
    (articles sorted by number of sources associating them with TP53)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a human p53 cDNA clone: expression of the human p53 gene. (PubMed id 6396087)1, 2, 3 Matlashewski G....Benchimol S. (1984)
    2. Potential Increase in the Prognostic Value of p53 Mutation by Pro72 Allele in Stage I Non-Small-Cell Lung Cancer. (PubMed id 19434453)1, 4, 9 Chien W.P....Lee H. (2009)
    3. Mutations in p53, p53 protein overexpression and brea st cancer survival. (PubMed id 19602056)1, 4, 9 Rossner P....Santella R.M. (2008)
    4. TP53 mutations in endometrial cancers: relation to PT EN gene defects. (PubMed id 20169661)1, 4, 9 Janiec-Jankowska A....NajmoA8a U. (2010)
    5. Using whole genome amplification (WGA) of low-volume biopsies to assess the prognostic role of EGFR, KRAS, p53, and CMET mutations in advanced-stage non-small cell lung cancer (NSCLC). (PubMed id 19096301)1, 4, 9 Lim E.H....Tan P. (2009)
    6. FAK overexpression and p53 mutations are highly corre lated in human breast cancer. (PubMed id 19521985)1, 4, 9 Golubovskaya V.M....Cance W.G. (2009)
    7. [Mutations of p53 gene in 41 cases of human brain gliomas] (PubMed id 18184456)1, 4, 9 Cui W....Wang X.C. (2008)
    8. Association of p53 and p21(CDKN1A/WAF1/CIP1) polymorphisms with oral cancer in Taiwan patients. (PubMed id 17595776)1, 4, 9 Bau D.T....Tsai F.J. (2007)
    9. TP53 mutations in breast cancer tumors of patients from Rio de Janeiro, Brazil: association with risk factors and tumor characteristics. (PubMed id 12209590)1, 4, 9 Simao T.A....de Moura-Gallo C.V. (2002)
    10. Mutations in the p53 tumor suppressor gene and early onset breast cancer. (PubMed id 12170762)1, 4, 9 Lai H....Meng L. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7157 HGNC: 11998 AceView: TP53 Ensembl:ENSG00000141510 euGenes: HUgn7157
    ECgene: TP53 Kegg: 7157 H-InvDB: TP53

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TP53 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TP53 Genetics and Cytogenetics in Oncology and Haematology
    IARC TP53 mutation databasehttp://www-p53.iarc.fr/
    The TP53 mutant web sitehttp://p53.fr/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TP53
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tp53/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=TP53
    Wikipedia http://en.wikipedia.org/wiki/P53

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TP53 gene:
    Search GeneIP for patents involving TP53

    Licensable Technologies for TP53 gene:
    Weizmann Institute:Treatment of Systemic Lupus Erythematosus by Down-Regulating the Autoimmune Response to Autoantigens    (see all 2)
     Salk Institute: Assays for p53 Function in Cells
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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