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TP53 Gene

protein-coding   GIFtS: 80
GCID: GC17M007565

Tumor Protein P53

  See TP53-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Tumor Protein P531 2     TRP532
P532 3 5     Cellular Tumor Antigen P532
Antigen NY-CO-132 3     Mutant Tumor Protein 532
Phosphoprotein P532 3     P53 Tumor Suppressor2
BCC72 5     Transformation-Related Protein 532
LFS12 5     Tumor Protein 532
Li-Fraumeni Syndrome1     Tumor Suppressor P533

External Ids:    HGNC: 119981   Entrez Gene: 71572   Ensembl: ENSG000001415107   OMIM: 1911705   UniProtKB: P046373   

Export aliases for TP53 gene to outside databases

Previous GC identifiers: GC17P008026 GC17M008311 GC17M007514 GC17M007772 GC17M007512 GC17M007465

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TP53 Gene:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and
oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of
target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism.
Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as
Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple
transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate
translation initiation codons (PMIDs: 12032546, 20937277). (provided by RefSeq, Feb 2013)

GeneCards Summary for TP53 Gene:
TP53 (tumor protein p53) is a protein-coding gene. Diseases associated with TP53 include multifocal osteogenic sarcoma, and eyelid neoplasm. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TP73.

UniProtKB/Swiss-Prot: P53_HUMAN, P04637
Function: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the
physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to
negatively regulate cell division by controlling a set of genes required for this process. One of the activated
genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation
of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF
is involved in activating oxidative stress-induced necrosis; the function is largely independent of
transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1.
LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to
effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when
associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the
transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses
transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform
1-mediated apoptosis

summary for TP53 Gene:
p53 (aka TP53) is a transcription factor whose protein levels and post-translational modification state
alter in response to cellular stress (such as DNA damage, hypoxia, spindle damage). Activation of p53 begins
through a number of mechanisms including phosphorylation by ATM, ATR, Chk1 and MAPKs. MDM2 is a ubiquitn
ligase that binds p53 and targets p53 for proteasomal degradation. Phosphorylation, p14ARF and USP7 prevent
MDM2-p53 interactions, leading to an increase in stable p53 tetramers in the cytoplasm. Further
modifications such as methylation and acetylation lead to an increase in p53 binding to gene specific
response elements. p53 regulates a large number of genes (>100 genes) that control a number of key tumor
suppressing functions such as cell cycle arrest, DNA repair, senescence and apoptosis. Whilst the activation
of p53 often leads to apoptosis, p53 inactivation facilitates tumor progression; inactivating p53 mutations
occur in over 50% of cancers.

Gene Wiki entry for TP53 (P53) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TP53 gene promoter:
         CREB   C/EBPbeta   Sp1   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): TP53 promoter sequence
   Search Chromatin IP Primers for TP53

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TP53

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

TP53 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP53 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007565:  view genomic region     (about GC identifiers)

7,565,097 bp from pter      End:
7,590,863 bp from pter
25,767 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TP53

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section

UniProtKB/Swiss-Prot: P53_HUMAN, P04637 (See protein sequence)
Recommended Name: Cellular tumor antigen p53  
Size: 393 amino acids; 43653 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1 (By similarity).
Binds DNA as a homotetramer. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and
CARM1, and recruits them to promoters. In vitro, the interaction of TP53 with cancer-associated/HPV (E6) viral
proteins leads to ubiquitination and degradation of TP53 giving a possible model for cell growth regulation. This
complex formation requires an additional factor, E6-AP, which stably associates with TP53 in the presence of E6.
Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this
interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1.
Interacts with WWOX. May interact with HCV core protein. Interacts with USP7 and SYVN1. Interacts with HSP90AB1.
Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity (By similarity).
Interacts with ARMC10, BANP, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F1. Interacts with YWHAZ; the interaction
enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts
(via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus).
Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with
FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the
phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation.
Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-382)
with L3MBTL1. Isoform 1 interacts with isoform 2 and with isoform 4. Interacts with GRK5. Binds to the CAK
complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with
AURKB, SETD2, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2.
Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the
association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by
cyclosporin A (CsA). Interacts with human cytomegalovirus/HHV-5 protein UL123. Interacts with SNAI1; the
interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion.
Interacts with KAT6A. Interacts with UBC9. Interacts with ZNF385B; the interaction is direct. Interacts (via
DNA-binding domain) with ZNF385A; the interaction is direct and enhances p53/TP53 transactivation functions on
cell-cycle arrest target genes, resulting in growth arrest. Interacts with ANKRD2. Interacts with RFFL (via
RING-type zinc finger); involved in p53/TP53 ubiquitination
Selected PDB 3D structures from and Proteopedia for TP53 (see all 119):
1A1U (3D)        1AIE (3D)        1C26 (3D)        1DT7 (3D)        1GZH (3D)        1H26 (3D)    
Secondary accessions: Q15086 Q15087 Q15088 Q16535 Q16807 Q16808 Q16809 Q16810 Q16811 Q16848
Q2XN98 Q3LRW1 Q3LRW2 Q3LRW3 Q3LRW4 Q3LRW5 Q86UG1 Q8J016 Q99659 Q9BTM4 Q9HAQ8 Q9NP68 Q9NPJ2
Alternative promoter usage, Alternative splicing: 9 isoforms:  P04637-1   P04637-2   P04637-3   P04637-4   P04637-5   P04637-6   P04637-7   P04637-8   
P04637-9   (Produced by alternative promoter usage and alternative splicing)

Explore the universe of human proteins at neXtProt for TP53: NX_P04637

Explore proteomics data for TP53 at MOPED

Post-translational modifications: 

  • Acetylated. Acetylation of Lys-382 by CREBBP enhances transcriptional activity. Deacetylation of Lys-382 by SIRT1
    impairs its ability to induce proapoptotic program and modulate cell senescence1
  • Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylated by HIPK1 (By similarity).
    Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter. Phosphorylated on Thr-18 by
    VRK1. Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2.
    Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated
    apoptosis. Phosphorylated on Thr-55 by TAF1, which promotes MDM2-mediated degradation. Phosphorylated on Ser-33
    by CDK7 in a CAK complex in response to DNA damage. Phosphorylated on Ser-46 by HIPK2 upon UV irradiation.
    Phosphorylation on Ser-46 is required for acetylation by CREBBP. Phosphorylated on Ser-392 following UV but not
    gamma irradiation. Phosphorylated on Ser-15 upon ultraviolet irradiation; which is enhanced by interaction with
    BANP. Phosphorylated by NUAK1 at Ser-15 and Ser-392; was intially thought to be mediated by STK11/LKB1 but it was
    later shown that it is indirect and that STK11/LKB1-dependent phosphorylation is probably mediated by downstream
    NUAK1 (PubMed:21317932). It is unclear whether AMP directly mediates phosphorylation at Ser-15. Phosphorylated on
    Thr-18 by isoform 1 and isoform 2 of VRK2. Phosphorylation on Thr-18 by isoform 2 of VRK2 results in a reduction
    in ubiquitination by MDM2 and an increase in acetylation by EP300. Stabilized by CDK5-mediated phosphorylation in
    response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53,
    particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated by DYRK2
    at Ser-46 in response to genotoxic stress. Phosphorylated at Ser-315 and Ser-392 by CDK2 in response to
  • Dephosphorylated by PP2A-PPP2R5C holoenzyme at Thr-55. SV40 small T antigen inhibits the dephosphorylation by the
    AC form of PP2A1
  • May be O-glycosylated in the C-terminal basic region. Studied in EB-1 cell line1
  • Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in
    cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not
    targeted to the proteasome. Ubiquitinated by MKRN1 at Lys-291 and Lys-292, which leads to proteasomal
    degradation. Deubiquitinated by USP10, leading to its stabilization. Ubiquitinated by TRIM24 and RFFL, which
    leads to proteasomal degradation. Ubiquitination by TOPORS induces degradation. Deubiquitination by USP7, leading
    to stabilization. Isoform 4 is monoubiquitinated in an MDM2-independent manner1
  • Monomethylated at Lys-372 by SETD7, leading to stabilization and increased transcriptional activation.
    Monomethylated at Lys-370 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional
    regulation activity. Lys-372 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at
    Lys-370. Dimethylated at Lys-373 by EHMT1 and EHMT2. Monomethylated at Lys-382 by SETD8, promoting interaction
    with L3MBTL1 and leading to repress transcriptional activity. Dimethylation at Lys-370 and Lys-382 diminishes p53
    ubiquitination, through stabilizing association with the methyl reader PHF20. Demethylation of dimethylated
    Lys-370 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation1
  • Sumoylated with SUMO1. Sumoylated at Lys-386 by UBC91
  • Ubiquitination2 at Lys101, Lys132, Lys164, Lys291, Lys292, Lys305, Lys320, Lys321
  • Modification sites at PhosphoSitePlus

  • See TP53 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (15 alternative transcripts): 
    NP_000537.3  NP_001119584.1  NP_001119585.1  NP_001119586.1  NP_001119587.1  NP_001119588.1  NP_001119589.1  NP_001119590.1  
    NP_001263624.1  NP_001263625.1  NP_001263626.1  NP_001263627.1  NP_001263628.1  NP_001263689.1  NP_001263690.1  

    ENSEMBL proteins: 
     ENSP00000410739   ENSP00000352610   ENSP00000269305   ENSP00000398846   ENSP00000391127  
     ENSP00000391478   ENSP00000458393   ENSP00000425104   ENSP00000423862   ENSP00000424104  
     ENSP00000473895   ENSP00000426252  
    Reactome Protein details: P04637

    TP53 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant TP53 Protein
    R&D Systems Recombinant & Natural Proteins for TP53 (p53)
    Enzo Life Sciences proteins for TP53
    OriGene Purified Proteins for TP53
    OriGene Protein Over-expression Lysate for TP53
    OriGene MassSpec for TP53
    OriGene Custom Protein Services for TP53
    GenScript Custom Purified and Recombinant Proteins Services for TP53
    Novus Biologicals TP53 Proteins
    Novus Biologicals TP53 Lysates
    Sino Biological Recombinant Protein for TP53
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TP53
    Cloud-Clone Corp. Proteins for TP53

    Search eBioscience for Proteins for TP53 

    antibodies-online proteins for TP53 (61 products) 

    antibodies-online peptides for TP53

    Search GeneTex for Proteins for TP53 

    TP53 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TP53
    R&D Systems Antibodies for TP53 (p53)
    Cell Signaling Technology (CST) Antibodies for TP53  (p53)
    OriGene Antibodies for TP53
    OriGene Custom Antibody Services for TP53
    Novus Biologicals TP53 Antibodies
    Abcam antibodies for TP53
    Cloud-Clone Corp. Antibodies for TP53
    ThermoFisher Antibody for TP53
    antibodies-online antibodies for TP53 (1437 products) 

    GeneTex Antibodies for TP53:  
                        TP53 Antibodies

    TP53 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of TP53
    OriGene Custom Assay Services for TP53
    R&D Systems ELISAs for TP53 (p53)         (see all)
    GenScript Custom Assay Services for TP53
    Cell Signaling Technology (CST) Sandwich ELISA Kits for TP53 (p53)
    Enzo Life Sciences assays for TP53
    Cloud-Clone Corp. ELISAs for TP53
    Cloud-Clone Corp. CLIAs for TP53
    eBioscience ELISAs for TP53: (see all 4
                        p53 (Total/Phospho) InstantOne ELISA 96 tests
    antibodies-online kits for TP53 (80 products) 

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    Selected InterPro protein domains (see all 6):
     IPR011615 p53_DNA-bd
     IPR012346 p53/RUNT-type_TF_DNA-bd
     IPR002117 p53_tumour_suppressor
     IPR008967 p53-like_TF_DNA-bd
     IPR013872 p53_transactivation_domain

    Graphical View of Domain Structure for InterPro Entry P04637

    ProtoNet protein and cluster: P04637

    1 Blocks protein domain: IPB010991 p53

    UniProtKB/Swiss-Prot: P53_HUMAN, P04637
    Domain: The nuclear export signal acts as a transcriptional repression domain. The TADI and TADII motifs (residues
    17 to 25 and 48 to 56) correspond both to 9aaTAD motifs which are transactivation domains present in a large
    number of yeast and animal transcription factors
    Similarity: Belongs to the p53 family

    Find genes that share domains with TP53           About GenesLikeMe

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P53_HUMAN, P04637
    Function: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the
    physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to
    negatively regulate cell division by controlling a set of genes required for this process. One of the activated
    genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation
    of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF
    is involved in activating oxidative stress-induced necrosis; the function is largely independent of
    transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1.
    LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to
    effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when
    associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the
    transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses
    transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform
    1-mediated apoptosis
    Induction: Up-regulated in response to DNA damage. Isoform 2 is not induced in tumor cells in response to stress

         Genatlas biochemistry entry for TP53:
    tumor suppressor protein p53 required for G1 growth arrest by WAF1 (CDKN1A),following DNA damage or induction of
    apoptosis,also regulating a G2 checkpoint through cyclin B1,transcriptional activator through acetylation of
    transactivation site by CREBBP binding MDM2 resulting in transcriptional silencing and ubiquitin/proteasome
    dependent degradation of p53,activated by conjugation to UBL1 (SUMO1),putative up-regulated c-MYC target
    gene,putative teratologic suppressor gene and modulator of TFIIH (GTF2H),associated in nucleotide excision
    repair,activated by ATM in association with 14.3.3 proteins (YWHA*),tumor suppressor gene (see TSG17A),mutated in
    cancers such as pancreas and endometrial carcinomas,in Barrett's adenocarcinoma (and esophageal squamous cell
    carcinoma),in hepatocellular carcinoma with poor prognosis

         Gene Ontology (GO): Selected molecular function terms (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IEA--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0001085RNA polymerase II transcription factor binding IPI18549481
    GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA17146433
    GO:0002020protease binding IPI11923872
    Find genes that share ontologies with TP53           About GenesLikeMe

         4 GenomeRNAi human phenotypes for TP53:
     Decreased viability of wild-ty  Enable proliferation in B-Raf   Increased cell death HMECs cel  Increased resistance to MDM2 i 

         Selected MGI mutant phenotypes (inferred from 73 alleles(MGI details for Trp53) (see all 27):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    Find genes that share phenotypes with TP53           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TP53: Trp53tm1Mlh Trp53tm3Wahl Trp53tm5Wahl Trp53tm2Wahl Trp53tm1.1Manf Trp53tm1Tyj
                                                         Trp53tm1Mok Trp53tm1Sia Trp53tm1.1Brn Trp53tm1Brd

       genOway: Develop your customized and physiologically relevant rodent model for TP53

        Taconic Biosicences: Generate A Custom CRISPR Mouse Model For Your Study 

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for TP53

    Transcription Factor Targeting: 

    Selected GeneGlobe predicted Target genes for TP53 (see all 1892):
    AATF,  ABCC3,  ABCC6P2,  ABCD1,  ABCF1,  ABHD12,  ABHD15,  ABHD4,  ABHD8,  ABTB2

    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  AACATGCCCAGACATGCCCN 

    miRTarBase miRNAs that target TP53:
    hsa-mir-1285-3p (MIRT005474), hsa-mir-125a-5p (MIRT004071), hsa-mir-221-3p (MIRT005785), hsa-mir-10b-5p (MIRT006923), hsa-mir-608 (MIRT016154), hsa-mir-324-5p (MIRT043041), hsa-mir-30d-5p (MIRT005418), hsa-mir-454-3p (MIRT039245), hsa-mir-16-5p (MIRT005764), hsa-mir-25-3p (MIRT005417), hsa-mir-15a-5p (MIRT005763), hsa-mir-605-5p (MIRT016155), hsa-mir-27a-3p (MIRT028744), hsa-mir-214-3p (MIRT006881), hsa-mir-34a-5p (MIRT007112), hsa-mir-150-5p (MIRT052652), hsa-mir-485-5p (MIRT016616), hsa-mir-222-3p (MIRT005786), hsa-mir-612 (MIRT005476), hsa-mir-504-5p (MIRT016257), hsa-mir-125b-5p (MIRT000535)

    Block miRNA regulation of human, mouse, rat TP53 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TP53 (see all 17):
    hsa-miR-576-3p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-98 hsa-miR-22
    SwitchGear 3'UTR luciferase reporter plasmidTP53 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for TP53
    Predesigned siRNA for gene silencing in human, mouse, rat TP53

    OriGene clones in human, mouse for TP53 (see all 37)
    OriGene ORF clones in mouse, rat for TP53
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): TP53 (NM_000546)
    Sino Biological Human cDNA Clone for TP53
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53
    Addgene plasmids for TP53 

    Cell Line
    GenScript Custom overexpressing Cell Line Services for TP53
    Browse ESI BIO Cell Lines and PureStem Progenitors for TP53 
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53

    Flow Cytometry

    eBioscience FlowRNA Probe Sets ( VA1-11152 VA6-13337) for TP53 

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Subcellular locations from UniProtKB/Swiss-Prot
    P53_HUMAN, P04637: Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix.
    Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2.
    Translocates to mitochondria upon oxidative stress
    P53_HUMAN, P04637: Isoform 1: Nucleus. Cytoplasm. Note=Predominantly nuclear but localizes to the cytoplasm
    when expressed with isoform 4
    P53_HUMAN, P04637: Isoform 2: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in
    the cytoplasm
    P53_HUMAN, P04637: Isoform 3: Nucleus. Cytoplasm. Note=Localized in the nucleus in most cells but found in the
    cytoplasm in some cells
    P53_HUMAN, P04637: Isoform 4: Nucleus. Cytoplasm. Note=Predominantly nuclear but translocates to the cytoplasm
    following cell stress
    P53_HUMAN, P04637: Isoform 7: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in
    the cytoplasm
    P53_HUMAN, P04637: Isoform 8: Nucleus. Cytoplasm. Note=Localized in both nucleus and cytoplasm in most cells.
    In some cells, forms foci in the nucleus that are different from nucleoli
    P53_HUMAN, P04637: Isoform 9: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    endoplasmic reticulum5
    plasma membrane2
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IBA--
    GO:0000790nuclear chromatin IDA15710329
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005657replication fork IBA--

    Find genes that share ontologies with TP53           About GenesLikeMe

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    SuperPaths for TP53 About   (see all 112)  
    See pathways by source

    SuperPathContained pathways About
    1Amyotrophic lateral sclerosis (ALS)
    Amyotrophic lateral sclerosis (ALS)0.63
    Pathogenesis of ALS0.31
    Amyotrophic lateral sclerosis (ALS)0.63
    Prostate cancer0.39
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    Bladder cancer0.31
    3Endometrial cancer
    Endometrial cancer0.45
    Colorectal cancer0.42
    Signal transduction PTEN pathway0.45
    4Development HGF signaling pathway
    Development Neurotrophin family signaling0.44
    Neurotrophin signaling pathway0.36
    Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    5Pyrimidine metabolism
    Fluoropyrimidine Activity0.69
    Fluoropyrimidine Pathway, Pharmacodynamics0.00

    Find genes that share SuperPaths with TP53           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for TP53
        Apoptosis Signaling Pathways
    Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TP53 (see all 41)
        Telomerase Components in Cell Signaling
    UVB-Induced MAPK Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer
    TRKA Signaling

    2 Cell Signaling Technology (CST) Pathways for TP53
        Cell Cycle / Checkpoint Control
    DNA Damage

    4 Tocris Bioscience Pathways for TP53
        Akt Pathway
    Apoptosis Pathway
    MAPK Pathway
    mTOR Pathway

    Selected GeneGo (Thomson Reuters) Pathways for TP53 (see all 13)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Immune response MIF in innate immunity response
    Transcription P53 signaling pathway
    Development Neurotrophin family signaling
    Signal transduction AKT signaling

    Selected BioSystems Pathways for TP53 (see all 38)
        MAPK signaling pathway
    Cell cycle
    Fluoropyrimidine Activity
    DNA damage response

    3 Sino Biological Pathways for TP53
        EGFR Signaling Pathway
    p53 Pathway
    Death Receptor Signaling

    Selected Reactome Pathways for TP53 (see all 11)
        Stabilization of p53
    Transcriptional activation of cell cycle inhibitor p21
    Oncogene Induced Senescence
    Activation of NOXA and translocation to mitochondria
    Activation of PUMA and translocation to mitochondria

    2 PharmGKB Pathways for TP53
        Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
    Fluoropyrimidine Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for TP53) (see all 33):
        MAPK signaling pathway
    Cell cycle
    p53 signaling pathway
    PI3K-Akt signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TP53 (see all 37): 
              Lung Cancer in human mouse rat
              Lymphoma in human mouse rat
              Prostate Cancer in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat


        GeneGlobe Interaction Network for TP53

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TP53 (P046371, 2, 3 ENSP000002693054) via UniProtKB, MINT, STRING, and/or I2D (see all 951) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009871, 2, 3, ENSP000004172814EBI-366083,EBI-389668 MINT-6540920 MINT-4793511 MINT-6823775 MINT-7013943 MINT-8303857 MINT-6540905 MINT-68742 MINT-8385459 MINT-56681 MINT-8374464 MINT-58468 MINT-7013791 MINT-68743 MINT-7013956 MINT-4545014 MINT-8339574 MINT-4049631 MINT-6540776 MINT-6801380 MINT-8374452 MINT-58465 MINT-7013688 MINT-7013802 MINT-4303990 MINT-8339590 MINT-6665330 MINT-4793467 MINT-8380636 MINT-4049616 MINT-4054304 MINT-7905142 MINT-8385480 MINT-7013780 MINT-6540889 MINT-8385531 MINT-8385552 MINT-8385886 MINT-8388795 MINT-8415355 MINT-6540807 MINT-8391984 MINT-7905326 MINT-6540796 I2D: score=12 STRING: ENSP00000417281
    OTUB1Q96FW11, 2, 3EBI-366083,EBI-1058491 MINT-8380020 MINT-8380061 MINT-8380636 MINT-8380008 MINT-8380032 MINT-8388795 MINT-8380053 MINT-8388765 I2D: score=1 
    HNRNPUL1Q9BUJ22, 3, ENSP000003758634MINT-58678 MINT-58677 MINT-58673 MINT-58674 MINT-58676 MINT-58675 MINT-8415355 MINT-58672 I2D: score=3 STRING: ENSP00000375863
    UBCP0CG481, 2, 3, ENSP000003448184EBI-366083,EBI-3390054 MINT-7220023 MINT-4051326 MINT-4304004 MINT-4054804 MINT-4304143 MINT-6801380 MINT-6615153 MINT-6541035 MINT-7299234 MINT-7298704 MINT-6799774 MINT-7013815 MINT-4052207 MINT-7219995 MINT-5114741 I2D: score=5 STRING: ENSP00000344818
    PSME3P612891, 2, 3, ENSP000002933624EBI-366083,EBI-355546 MINT-6540807 MINT-6540940 MINT-6540866 MINT-6540920 MINT-6540876 MINT-6540776 MINT-6541016 MINT-6540960 MINT-6540796 I2D: score=3 STRING: ENSP00000293362
    ENSG00000237724P081073, ENSP000004063594I2D: score=3 STRING: ENSP00000406359
    HSPA1AP081073, ENSP000003648024I2D: score=3 STRING: ENSP00000364802
    EP300Q094721, 2, 3, ENSP000002632534EBI-366083,EBI-447295 MINT-69507 MINT-8152513 MINT-8152530 MINT-8392126 MINT-2830826 MINT-7263630 MINT-8152544 MINT-6628507 I2D: score=7 STRING: ENSP00000263253
    MKRN1Q9UHC71, 2, 3, ENSP000002559774EBI-366083,EBI-373524 MINT-7298755 MINT-7298834 MINT-7298907 MINT-7298873 MINT-7298815 MINT-7298791 MINT-7298847 MINT-7298737 I2D: score=1 STRING: ENSP00000255977
    ENSG00000212866P081073I2D: score=3 
    ENSG00000215328P081073I2D: score=3 
    ENSG00000224501P081073I2D: score=3 
    ENSG00000231555P081073I2D: score=3 
    ENSG00000232804P081073I2D: score=3 
    ENSG00000234475P081073I2D: score=3 
    ENSG00000235941P081073I2D: score=3 
    HSPA1BP081073I2D: score=3 
    MDM4O151511, 2, 3, ENSP000003561504EBI-366083,EBI-398437 MINT-7291988 MINT-7292025 MINT-7291962 MINT-2517887 MINT-7291975 MINT-7896820 MINT-7896835 I2D: score=7 STRING: ENSP00000356150
    YWHAGP619811, 2, 3, ENSP000003063304EBI-366083,EBI-359832 MINT-8008651 MINT-8008679 MINT-8009392 MINT-8008658 MINT-8009385 MINT-8415355 MINT-8009378 I2D: score=2 STRING: ENSP00000306330
    E6P031261, 2EBI-366083,EBI-1186926 MINT-73145 MINT-73436 MINT-69510 MINT-69619 EBI-366083,EBI-1177242 MINT-73434 MINT-69729 MINT-6628341 MINT-73143
    -Q8QW271EBI-366083,EBI-6863726 EBI-366083,EBI-6838571 EBI-366083,EBI-617698 MINT-69740 MINT-6628483 MINT-6733190 MINT-69730 MINT-73318 MINT-6628495 MINT-6628706 MINT-6733198 MINT-73205 MINT-7277322 MINT-73319 MINT-6627917 MINT-6628699 MINT-5162111 MINT-6628692
    USP7Q930091, 2, 3, ENSP000003435354EBI-366083,EBI-302474 MINT-4304022 MINT-14904 MINT-15878 MINT-15877 MINT-8415355 MINT-15876 I2D: score=6 STRING: ENSP00000343535
    ARIH2O953761, 2, 3, ENSP000003487694EBI-366083,EBI-711158 MINT-8385595 MINT-8385459 MINT-8385531 MINT-8385886 MINT-8385510 MINT-63290 I2D: score=5 STRING: ENSP00000348769
    PLK1P533501, 2, 3, ENSP000003000934EBI-366083,EBI-476768 MINT-2634858 MINT-7266250 MINT-8415512 MINT-2634822 MINT-2634880 MINT-2634842 I2D: score=2 STRING: ENSP00000300093
    GTF2H1P327801, 2, 3, ENSP000002659634EBI-366083,EBI-715539 MINT-6544200 MINT-6544239 MINT-6544220 MINT-6544181 MINT-6544161 I2D: score=4 STRING: ENSP00000265963
    PIN1Q135261, 2, 3, ENSP000002479704EBI-366083,EBI-714158 MINT-19991 MINT-19990 MINT-8266557 MINT-19916 MINT-19915 I2D: score=4 STRING: ENSP00000247970
    TPT1P136931, 2, 3, ENSP000003683504EBI-366083,EBI-1783169 MINT-8057126 MINT-8057107 MINT-8057141 MINT-8057116 MINT-8057160 I2D: score=2 STRING: ENSP00000368350
    BHLHE40O145031, 2, 3, ENSP000002564954EBI-366083,EBI-711810 MINT-4544966 MINT-4545030 MINT-4654062 MINT-4545046 MINT-4544983 I2D: score=1 STRING: ENSP00000256495
    ENSG00000206206Q9UER71, 2, 3EBI-366083,EBI-77321 MINT-2574339 I2D: score=5 
    ENSG00000206279Q9UER71, 2, 3EBI-366083,EBI-77321 MINT-2574339 I2D: score=5 
    ENSG00000227046Q9UER71, 2, 3EBI-366083,EBI-77321 MINT-2574339 I2D: score=5 
    ENSG00000231617Q9UER71, 2, 3EBI-366083,EBI-77321 MINT-2574339 I2D: score=5 
    HSPA9P386461, 2, 3, ENSP000002971854EBI-366083,EBI-354932 MINT-4302632 MINT-7557611 MINT-7557644 MINT-7557580 I2D: score=5 STRING: ENSP00000297185
    RYBPQ8N4881, 2, 3, ENSP000004194944EBI-366083,EBI-752324 MINT-7013916 MINT-7013688 MINT-7013780 MINT-7013930 I2D: score=2 STRING: ENSP00000419494
    ZNF420Q8TAQ51, 2, 3, ENSP000003387704EBI-366083,EBI-3923307 MINT-7989670 MINT-7989584 MINT-7989724 MINT-7989773 I2D: score=2 STRING: ENSP00000338770
    GSK3BP498411, 2, 3, ENSP000003248064EBI-366083,EBI-373586 MINT-4793219 MINT-4793253 MINT-8257746 I2D: score=5 STRING: ENSP00000324806
    MT1AP047311, 2, 3, ENSP000002907054EBI-366083,EBI-8045030 MINT-1781444 MINT-1781494 MINT-1781525 I2D: score=1 STRING: ENSP00000290705
    TOE1Q96GM81, 2, 3, ENSP000003611624EBI-366083,EBI-717460 MINT-7144884 MINT-7144912 MINT-7144895 I2D: score=1 STRING: ENSP00000361162
    CREBBPQ927931, 2, 3, ENSP000002623674EBI-366083,EBI-81215 MINT-6665320 MINT-6665337 I2D: score=7 STRING: ENSP00000262367
    PARP1P098741, 2, 3, ENSP000003557594EBI-366083,EBI-355676 MINT-16978 MINT-16977 I2D: score=5 STRING: ENSP00000355759
    NCLP193381, 2, 3, ENSP000003181954EBI-366083,EBI-346967 MINT-8292070 MINT-8292213 I2D: score=4 STRING: ENSP00000318195
    YWHAZP631041, 2, 3, ENSP000003095034EBI-366083,EBI-347088 MINT-74925 MINT-8415355 I2D: score=4 STRING: ENSP00000309503
    SFNP319471, 2, 3, ENSP000003409894EBI-366083,EBI-476295 MINT-7711931 MINT-7711943 I2D: score=2 STRING: ENSP00000340989
    S100A1P232971, 2, 3, ENSP000002921694EBI-366083,EBI-743686 MINT-7905174 MINT-7905308 I2D: score=1 STRING: ENSP00000292169
    SNAI1O958631, 2, 3, ENSP000002440504EBI-366083,EBI-1045459 MINT-7718928 MINT-7718917 I2D: score=1 STRING: ENSP00000244050
    USP42Q9H9J41, 2, 3, ENSP000003019624EBI-366083,EBI-2513638 MINT-8303846 MINT-8303829 I2D: score=1 STRING: ENSP00000301962
    CUL9Q8IWT31, 2, 3, ENSP000002520504EBI-366083,EBI-311123 MINT-8415355 I2D: score=5 STRING: ENSP00000252050
    UBE3AQ050861, 2, 3, ENSP000003810454EBI-366083,EBI-954357 MINT-6628330 I2D: score=4 STRING: ENSP00000381045
    CUL7Q149991, 2, 3, ENSP000002653484EBI-366083,EBI-308606 MINT-8415355 I2D: score=2 STRING: ENSP00000265348
    KAT8Q9H7Z61, 2, 3, ENSP000004060374EBI-366083,EBI-896414 MINT-1897583 I2D: score=2 STRING: ENSP00000406037
    PPP1R13LQ8WUF51, 2, 3, ENSP000003542184EBI-366083,EBI-5550163 MINT-8152544 I2D: score=2 STRING: ENSP00000354218
    PPP2R5CQ133621, 2, 3, ENSP000003339054EBI-366083,EBI-1266156 MINT-4299201 I2D: score=1 STRING: ENSP00000333905
    BTBD2Q9BX701, 2, 3EBI-366083,EBI-710091 MINT-65379 I2D: score=5 
    NRD1O438471, 2EBI-366083,EBI-2371631 MINT-8415621 MINT-8415512 MINT-8415713 MINT-8415610 MINT-8415694 MINT-8415680
    SAFBQ154241, 2, ENSP000002921234EBI-366083,EBI-348298 MINT-8072012 MINT-8074581 MINT-8074790 MINT-8072027 MINT-8072038 STRING: ENSP00000292123
    ENSG00000234258P349312, 3, ENSP000003964864MINT-4302642 I2D: score=2 STRING: ENSP00000396486
    SP1P080472, 3, ENSP000003293574MINT-56525 MINT-56523 MINT-56524 I2D: score=6 STRING: ENSP00000329357
    MED1Q156482, 3, ENSP000003006514MINT-58470 MINT-58467 MINT-58464 I2D: score=4 STRING: ENSP00000300651
    ENSG00000206383P349312, 3MINT-4302642 I2D: score=2 
    ENSG00000236251P349312, 3MINT-4302642 I2D: score=2 
    HSPA1LP349312, 3MINT-4302642 I2D: score=2 
    YWHAEP622582, 3, ENSP000002643354MINT-8008686 MINT-8008665 MINT-8008672 I2D: score=1 STRING: ENSP00000264335
    NR0B2Q154661, 2, ENSP000002542274EBI-366083,EBI-3910729 MINT-8331203 MINT-8331211 MINT-8339604 STRING: ENSP00000254227
    UBE2IP632792, 3, ENSP000003248974MINT-50578 MINT-50579 I2D: score=6 STRING: ENSP00000324897
    BRCA1P383982, 3, ENSP000003502834MINT-16162 MINT-16161 I2D: score=5 STRING: ENSP00000350283
    DVL2O146412, 3, ENSP000000053404MINT-67597 MINT-2858243 I2D: score=5 STRING: ENSP00000005340
    TK1P041832, 3, ENSP000003016344MINT-63365 MINT-8274236 I2D: score=5 STRING: ENSP00000301634
    SMN1Q166372, 3, ENSP000003700834MINT-8271608 I2D: score=3 STRING: ENSP00000370083
    MAGEA2BP433561, 3, ENSP000003334874EBI-366083,EBI-5650739 I2D: score=1 STRING: ENSP00000333487
    MPDZO759701, 2EBI-366083,EBI-821405 MINT-8415632 MINT-8415643 MINT-8415512
    PARD3Q8TEW01, 2EBI-366083,EBI-81968 MINT-8415654 MINT-8415512 MINT-8415665
    BCL2L1Q078172, 3, ENSP000003025644MINT-8249399 I2D: score=6 STRING: ENSP00000302564
    PIAS1O759251, 3, ENSP000002496364EBI-366083,EBI-629434 I2D: score=6 STRING: ENSP00000249636
    TOPORSQ9NS562, 3, ENSP000003537354MINT-4329805 I2D: score=6 STRING: ENSP00000353735
    CDKN2CP427732, 3, ENSP000002626624MINT-63749 I2D: score=5 STRING: ENSP00000262662
    COX17Q140612, 3, ENSP000002610704MINT-64164 I2D: score=5 STRING: ENSP00000261070
    EGR1P181462, 3, ENSP000002399384MINT-4793180 I2D: score=5 STRING: ENSP00000239938
    EIF2S2P200422, 3, ENSP000003641194MINT-63537 I2D: score=5 STRING: ENSP00000364119
    HTTP428581, 3, ENSP000003471844EBI-366083,EBI-466029 I2D: score=5 STRING: ENSP00000347184
    S100A8P051092, 3, ENSP000003577214MINT-63391 I2D: score=5 STRING: ENSP00000357721
    TP63Q9H3D41, 3, ENSP000002647314EBI-366083,EBI-2337775 I2D: score=5 STRING: ENSP00000264731
    HIPK2Q9H2X62, 3MINT-68744 MINT-60094 I2D: score=4 
    ING1Q9UK532, 3, ENSP000003649294MINT-6615153 I2D: score=4 STRING: ENSP00000364929
    NFYAP235111, 3, ENSP000003457024EBI-366083,EBI-389739 I2D: score=4 STRING: ENSP00000345702
    WRNQ141911, 3, ENSP000002981394EBI-366083,EBI-368417 I2D: score=4 STRING: ENSP00000298139
    DDX5P178441, 3, ENSP000002257924EBI-366083,EBI-351962 I2D: score=3 STRING: ENSP00000225792
    EEF2P136392, 3, ENSP000003079404MINT-8415355 I2D: score=3 STRING: ENSP00000307940
    IKBKBO149202, 3, ENSP000003391514MINT-7295816 I2D: score=3 STRING: ENSP00000339151
    ING4Q9UNL42, 3, ENSP000003800244MINT-50659 I2D: score=3 STRING: ENSP00000380024
    PPP1CAP621362, 3, ENSP000003260314MINT-62206 I2D: score=3 STRING: ENSP00000326031
    SETD7Q8WTS61, 3, ENSP000002740314EBI-366083,EBI-1268586 I2D: score=3 STRING: ENSP00000274031
    CEBPBP176761, 3, ENSP000003054224EBI-366083,EBI-969696 I2D: score=2 STRING: ENSP00000305422
    FBXO11Q86XK21, 3, ENSP000003238224EBI-366083,EBI-1047804 I2D: score=2 STRING: ENSP00000323822
    HSPA5P110212, 3, ENSP000003241734MINT-4052873 I2D: score=2 STRING: ENSP00000324173
    MAPK11Q157591, 3, ENSP000003336854EBI-366083,EBI-298304 I2D: score=2 STRING: ENSP00000333685
    USP29Q9HBJ72, 3, ENSP000002541814MINT-8145730 I2D: score=2 STRING: ENSP00000254181
    COPS4Q9BT782, 3, ENSP000002643894MINT-8415355 I2D: score=1 STRING: ENSP00000264389
    CSE1LP550601, 3, ENSP000002629824EBI-366083,EBI-286709 I2D: score=1 STRING: ENSP00000262982
    DYNC1I1O145762, 3, ENSP000003201304MINT-1891331 I2D: score=1 STRING: ENSP00000320130
    KDM1AO603412, 3, ENSP000003490494MINT-8415512 I2D: score=1 STRING: ENSP00000349049
    MAGEA2P433561, 3EBI-366083,EBI-5650739 I2D: score=1 
    PAGR1Q9BTK62, 3, ENSP000003265194MINT-7013631 I2D: score=1 STRING: ENSP00000326519
    S100A6P067032, 3, ENSP000003577084MINT-7905207 I2D: score=1 STRING: ENSP00000357708
    TP53P046371, 2EBI-366083,EBI-366083 MINT-6628330 MINT-8415355
    CCL18P557742, 3MINT-63883 I2D: score=6 
    ANXA3P124292, 3MINT-63460 I2D: score=5 
    ARL3P364052, 3MINT-63694 I2D: score=5 
    ERHP840902, 3MINT-64020 I2D: score=5 
    FXYD6Q9H0Q32, 3MINT-65439 I2D: score=5 
    MAD2L1BPQ150132, 3MINT-64188 I2D: score=5 
    MPHOSPH6Q995472, 3MINT-65272 I2D: score=5 
    PAFAH1B3Q151022, 3MINT-64202 I2D: score=5 
    PNPP004912, 3MINT-63335 I2D: score=5 
    PSMD11O002312, 3MINT-63023 I2D: score=5 
    RAB4AP203382, 3MINT-63547 I2D: score=5 
    SAT1P216732, 3MINT-63559 I2D: score=5 
    SERPINB9P504532, 3MINT-63814 I2D: score=5 
    STX5Q131902, 3MINT-64119 I2D: score=5 
    SULT1E1P498882, 3MINT-63800 I2D: score=5 
    THAP8Q8NA922, 3MINT-64946 I2D: score=5 
    ZCCHC10Q8TBK62, 3MINT-65034 I2D: score=5 
    ZNF24P170282, 3MINT-63497 I2D: score=5 
    MAPKAPK5Q8IW411, 3EBI-366083,EBI-1201460 I2D: score=4 
    PCDHA4Q9UN742, 3MINT-65770 I2D: score=4 
    PPA1Q151812, 3MINT-64729 I2D: score=4 
    DLEU1O432612, 3MINT-63114 I2D: score=3 
    GUSBP1Q154862, 3MINT-64247 I2D: score=3 
    KIAA0087Q146952, 3MINT-64748 I2D: score=3 
    SCAMP1O151262, 3MINT-2866927 I2D: score=3 
    ANXA7P200732, 3MINT-8248834 I2D: score=2 
    RAP1BP612242, 3MINT-8268163 I2D: score=2 
    UFD1LQ928902, 3MINT-8276859 I2D: score=2 
    RPS27AP629792, 3MINT-8415355 I2D: score=1 
    XPO1O149802, 3MINT-4303978 I2D: score=1 
    ENSG00000206481Q146763, ENSP000003730604I2D: score=3 STRING: ENSP00000373060
    MDC1Q146763, ENSP000003655884I2D: score=3 STRING: ENSP00000365588
    DAXXQ9UER71, 2, 3, ENSP000003968764EBI-366083,EBI-77321 MINT-2574339 I2D: score=5 STRING: ENSP00000396876 STRING: ENSP00000266000
    MAP1BP468211, 2, 3, ENSP000002967554EBI-366083,EBI-764611 MINT-6701791 MINT-6701342 MINT-6702266 MINT-6706444 MINT-6700861 MINT-6702529 I2D: score=1 STRING: ENSP00000296755
    NR4A1P227361, 2, 3, ENSP000002430504EBI-366083,EBI-721550 MINT-4049673 MINT-4049689 MINT-4049732 MINT-4049598 MINT-4049708 MINT-4049650 I2D: score=3 STRING: ENSP00000243050
    ENSG00000224587Q146763I2D: score=3 
    ENSG00000225589Q146763I2D: score=3 
    ENSG00000228575Q146763I2D: score=3 
    ENSG00000231135Q146763I2D: score=3 
    ENSG00000234012Q146763I2D: score=3 
    ENSG00000237095Q146763I2D: score=3 
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    ENSG00000232960P678703I2D: score=2 
    HDAC1Q135471, 2, 3, ENSP000003626494EBI-366083,EBI-301834 MINT-7893049 MINT-7893085 MINT-7893074 MINT-7893061 I2D: score=5 STRING: ENSP00000362649
    NPM1P067481, 2, 3, ENSP000002969304EBI-366083,EBI-78579 MINT-74886 MINT-8391984 MINT-74887 MINT-74888 I2D: score=6 STRING: ENSP00000296930
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    ENSG00000236759Q96KQ73I2D: score=1 
    ENSG00000238134Q96KQ73I2D: score=1 
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    ENSG00000238196Q994663I2D: score=1 
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