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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TP53 Gene

protein-coding   GIFtS: 81
GCID: GC17M007565

Tumor Protein P53

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 5

Aliases
Tumor Protein P531 2     BCC72
P532 3 5     TRP532
Antigen NY-CO-132 3     Cellular Tumor Antigen P532
Phosphoprotein P532 3     P53 Tumor Suppressor2
LFS12 5     Transformation-Related Protein 532
Li-Fraumeni Syndrome1     Tumor Suppressor P533

External Ids:    HGNC: 119981   Entrez Gene: 71572   Ensembl: ENSG000001415107   OMIM: 1911705   UniProtKB: P046373   
ORGUL members:    fRNAdb10:FR343586 FR325937      
H-InvDB12:HIT000195796    
NCBI13:U58658 M55576    
NONCODE14:n335267 n337087 n343020      
RNAdb15:LIT1750 HIV2718    

Export aliases for TP53 gene to outside databases

Previous GC identifers: GC17P008026 GC17M008311 GC17M007514 GC17M007772 GC17M007512 GC17M007465


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TP53 Gene:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and
oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of
target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism.
Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as
Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple
transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate
translation initiation codons (PMIDs: 12032546, 20937277). (provided by RefSeq, Feb 2013)

GeneCards Summary for TP53 Gene: 
TP53 (tumor protein p53) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with TP53 include li-fraumeni syndrome, and adrenocortical carcinoma, and among its related super-pathways are Glioma and Endometrial cancer. GO annotations related to this gene include identical protein binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TP73.

UniProtKB/Swiss-Prot: P53_HUMAN, P04637
Function: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the
physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to
negatively regulate cell division by controlling a set of genes required for this process. One of the activated
genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation
of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF
is involved in activating oxidative stress-induced necrosis; the function is largely independent of
transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1.
LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to
effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when
associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the
transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses
transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform
1-mediated apoptosis

summary for TP53 Gene:
p53 (aka TP53) is a transcription factor whose protein levels and post-translational modification state
alter in response to cellular stress (such as DNA damage, hypoxia, spindle damage). Activation of p53 begins
through a number of mechanisms including phosphorylation by ATM, ATR, Chk1 and MAPKs. MDM2 is a ubiquitn
ligase that binds p53 and targets p53 for proteasomal degradation. Phosphorylation, p14ARF and USP7 prevent
MDM2-p53 interactions, leading to an increase in stable p53 tetramers in the cytoplasm. Further
modifications such as methylation and acetylation lead to an increase in p53 binding to gene specific
response elements. p53 regulates a large number of genes (>100 genes) that control a number of key tumor
suppressing functions such as cell cycle arrest, DNA repair, senescence and apoptosis. Whilst the activation
of p53 often leads to apoptosis, p53 inactivation facilitates tumor progression; inactivating p53 mutations
occur in over 50% of cancers.

Gene Wiki entry for TP53 (P53) Gene

fRNAdb sequence ontologies for TP53 - the ORGUL cluster for this gene includes several descriptions:
intron - A region of a primary transcript that is transcribed, but removed from within the transcript by splicing together the sequences (exons) on either side of it.
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for TP53

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TP53 gene promoter:
         CREB   C/EBPbeta   Sp1   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): TP53 promoter sequence
   Search SABiosciences Chromatin IP Primers for TP53

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TP53


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

TP53 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP53 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007565:  view genomic region     (about GC identifiers)

Start:
7,565,097 bp from pter      End:
7,590,863 bp from pter
Size:
25,767 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TP53

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: P53_HUMAN, P04637 (See protein sequence)
Recommended Name: Cellular tumor antigen p53  
Size: 393 amino acids; 43653 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1 (By similarity).
Binds DNA as a homotetramer. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and
CARM1, and recruits them to promoters. In vitro, the interaction of TP53 with cancer-associated/HPV (E6) viral
proteins leads to ubiquitination and degradation of TP53 giving a possible model for cell growth regulation. This
complex formation requires an additional factor, E6-AP, which stably associates with TP53 in the presence of E6.
Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this
interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1.
Interacts with WWOX. May interact with HCV core protein. Interacts with USP7 and SYVN1. Interacts with HSP90AB1.
Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity (By similarity).
Interacts with ARMC10, BANP, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F1. Interacts with YWHAZ; the interaction
enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts
(via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus).
Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with
FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the
phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation.
Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-382)
with L3MBTL1. Isoform 1 interacts with isoform 2 and with isoform 4. Interacts with GRK5. Binds to the CAK
complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with
AURKB, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2.
Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the
association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by
cyclosporin A (CsA). Interacts with human cytomegalovirus/HHV-5 protein UL123. Interacts with SNAI1; the
interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion.
Interacts with KAT6A. Interacts with UBC9. Interacts with ZNF385B; the interaction is direct. Interacts (via
DNA-binding domain) with ZNF385A; the interaction is direct and enhances p53/TP53 transactivation functions on
cell-cycle arrest target genes, resulting in growth arrest
Subcellular location: Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix.
Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2.
Translocates to mitochondria upon oxidative stress
Subcellular location: Isoform 1: Nucleus. Cytoplasm. Note=Predominantly nuclear but localizes to the cytoplasm
when expressed with isoform 4
Subcellular location: Isoform 2: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in
the cytoplasm
Subcellular location: Isoform 3: Nucleus. Cytoplasm. Note=Localized in the nucleus in most cells but found in the
cytoplasm in some cells
Subcellular location: Isoform 4: Nucleus. Cytoplasm. Note=Predominantly nuclear but translocates to the cytoplasm
following cell stress
Subcellular location: Isoform 7: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in
the cytoplasm
Subcellular location: Isoform 8: Nucleus. Cytoplasm. Note=Localized in both nucleus and cytoplasm in most cells.
In some cells, forms foci in the nucleus that are different from nucleoli
Subcellular location: Isoform 9: Cytoplasm
6/103 PDB 3D structures from and Proteopedia for TP53 (see all 103):
1A1U (3D)        1AIE (3D)        1C26 (3D)        1DT7 (3D)        1GZH (3D)        1H26 (3D)    
Secondary accessions: Q15086 Q15087 Q15088 Q16535 Q16807 Q16808 Q16809 Q16810 Q16811 Q16848
Q2XN98 Q3LRW1 Q3LRW2 Q3LRW3 Q3LRW4 Q3LRW5 Q86UG1 Q8J016 Q99659 Q9BTM4 Q9HAQ8 Q9NP68 Q9NPJ2
Q9NZD0 Q9UBI2 Q9UQ61
Alternative promoter usage, Alternative splicing: 9 isoforms:  P04637-1   P04637-2   P04637-3   P04637-4   P04637-5   P04637-6   P04637-7   P04637-8   
P04637-9   (Produced by alternative promoter usage and alternative splicing)

Explore the universe of human proteins at neXtProt for TP53: NX_P04637

Explore proteomics data for TP53 at MOPED 

Post-translational modifications:

  • UniProtKB: Acetylated. Acetylation of Lys-382 by CREBBP enhances transcriptional activity. Deacetylation of Lys-382 by SIRT1
    impairs its ability to induce proapoptotic program and modulate cell senescence
  • UniProtKB: Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylated by HIPK1 (By similarity).
    Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter. Phosphorylated on Thr-18 by
    VRK1. Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2.
    Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated
    apoptosis. Phosphorylated on Thr-55 by TAF1, which promotes MDM2-mediated degradation. Phosphorylated on Ser-33
    by CDK7 in a CAK complex in response to DNA damage. Phosphorylated on Ser-46 by HIPK2 upon UV irradiation.
    Phosphorylation on Ser-46 is required for acetylation by CREBBP. Phosphorylated on Ser-392 following UV but not
    gamma irradiation. Phosphorylated on Ser-15 upon ultraviolet irradiation; which is enhanced by interaction with
    BANP. Phosphorylated by NUAK1 at Ser-15 and Ser-392; was intially thought to be mediated by STK11/LKB1 but it was
    later shown that it is indirect and that STK11/LKB1-dependent phosphorylation is probably mediated by downstream
    NUAK1 (PubMed:21317932). It is unclear whether AMP directly mediates phosphorylation at Ser-15. Phosphorylated on
    Thr-18 by isoform 1 and isoform 2 of VRK2. Phosphorylation on Thr-18 by isoform 2 of VRK2 results in a reduction
    in ubiquitination by MDM2 and an increase in acetylation by EP300. Stabilized by CDK5-mediated phosphorylation in
    response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53,
    particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated by DYRK2
    at Ser-46 in response to genotoxic stress. Phosphorylated at Ser-315 and Ser-392 by CDK2 in response to
    DNA-damage
  • UniProtKB: Dephosphorylated by PP2A-PPP2R5C holoenzyme at Thr-55. SV40 small T antigen inhibits the dephosphorylation by the
    AC form of PP2A
  • UniProtKB: May be O-glycosylated in the C-terminal basic region. Studied in EB-1 cell line
  • UniProtKB: Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in
    cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not
    targeted to the proteasome. Ubiquitinated by MKRN1 at Lys-291 and Lys-292, which leads to proteasomal
    degradation. Deubiquitinated by USP10, leading to its stabilization. Ubiquitinated by TRIM24, which leads to
    proteasomal degradation. Ubiquitination by TOPORS induces degradation. Deubiquitination by USP7, leading to
    stabilization. Isoform 4 is monoubiquitinated in an MDM2-independent manner
  • UniProtKB: Monomethylated at Lys-372 by SETD7, leading to stabilization and increased transcriptional activation.
    Monomethylated at Lys-370 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional
    regulation activity. Lys-372 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at
    Lys-370. Dimethylated at Lys-373 by EHMT1 and EHMT2. Monomethylated at Lys-382 by SETD8, promoting interaction
    with L3MBTL1 and leading to repress transcriptional activity. Dimethylation at Lys-370 and Lys-382 diminishes p53
    ubiquitination, through stabilizing association with the methyl reader PHF20. Demethylation of dimethylated
    Lys-370 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation
  • UniProtKB: Sumoylated with SUMO1. Sumoylated at Lys-386 by UBC9
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04637

  • TP53 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TP53 Protein Expression
    REFSEQ proteins (15 alternative transcripts): 
    NP_000537.3  NP_001119584.1  NP_001119585.1  NP_001119586.1  NP_001119587.1  NP_001119588.1  NP_001119589.1  NP_001119590.1  
    NP_001263624.1  NP_001263625.1  NP_001263626.1  NP_001263627.1  NP_001263628.1  NP_001263689.1  NP_001263690.1  

    ENSEMBL proteins: 
     ENSP00000410739   ENSP00000352610   ENSP00000269305   ENSP00000398846   ENSP00000391127  
     ENSP00000391478   ENSP00000458393   ENSP00000425104   ENSP00000423862   ENSP00000424104  
     ENSP00000473895   ENSP00000426252  
    Reactome Protein details: P04637
    Human Recombinant Protein Products for TP53: 
    EMD Millipore Purified and/or Recombinant TP53 Protein
    R&D Systems Recombinant & Natural Proteins for TP53 (p53)
    Enzo Life Sciences proteins for TP53
    OriGene Purified Proteins for TP53
    OriGene Protein Over-expression Lysate for TP53
    OriGene MassSpec for TP53 
    OriGene Custom Protein Services for TP53
    GenScript Custom Purified and Recombinant Proteins Services for TP53
    Novus Biologicals TP53 Proteins
    Novus Biologicals TP53 Lysates
    Sino Biological Recombinant Protein for TP53
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TP53
    Cloud-Clone Corp. Proteins for TP53 

    Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IBA--
    GO:0000790nuclear chromatin IDA15710329
    GO:0005634nucleus IDA14744935
    GO:0005654nucleoplasm TAS--
    GO:0005657replication fork IBA--

    TP53 for ontologies           About GeneDecksing



    TP53 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TP53
    R&D Systems Antibodies for TP53 (p53)
    Cell Signaling Technology (CST) Antibodies for TP53  (p53)
    OriGene Antibodies for TP53
    OriGene Custom Antibody Services for TP53
    GenScript Superior Antibodies for TP53
    Novus Biologicals TP53 Antibodies
    Abcam antibodies for TP53
    Cloud-Clone Corp. Antibodies for TP53 
    ThermoFisher Antibody for TP53
    LSBio Antibodies in human, mouse, rat for TP53 

    Assay Products for TP53: 
    EMD Millipore Kits and Assays for the Analysis of TP53
    OriGene Custom Assay Services for TP53
    R&D Systems ELISAs for TP53 (p53)         (see all)
    GenScript Custom Assay Services for TP53
    Cell Signaling Technology (CST) Sandwich ELISA Kits for TP53 (p53)
    Enzo Life Sciences assays for TP53
    Cloud-Clone Corp. ELISAs for TP53 
    Cloud-Clone Corp. CLIAs for TP53


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR011615 p53_DNA-bd
     IPR010991 p53_tetrameristn
     IPR012346 p53/RUNT-type_TF_DNA-bd
     IPR002117 p53_tumour_suppressor
     IPR008967 p53-like_TF_DNA-bd

    Graphical View of Domain Structure for InterPro Entry P04637

    ProtoNet protein and cluster: P04637

    1 Blocks protein domain: IPB010991 p53

    UniProtKB/Swiss-Prot: P53_HUMAN, P04637
    Domain: The nuclear export signal acts as a transcriptional repression domain. The TADI and TADII motifs (residues
    17 to 25 and 48 to 56) correspond both to 9aaTAD motifs which are transactivation domains present in a large
    number of yeast and animal transcription factors
    Similarity: Belongs to the p53 family


    TP53 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P53_HUMAN, P04637
    Function: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the
    physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to
    negatively regulate cell division by controlling a set of genes required for this process. One of the activated
    genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation
    of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF
    is involved in activating oxidative stress-induced necrosis; the function is largely independent of
    transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1.
    LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to
    effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when
    associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the
    transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses
    transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform
    1-mediated apoptosis
    Induction: Up-regulated in response to DNA damage. Isoform 2 is not induced in tumor cells in response to stress

         Genatlas biochemistry entry for TP53:
    tumor suppressor protein p53 required for G1 growth arrest by WAF1 (CDKN1A),following DNA damage or induction of
    apoptosis,also regulating a G2 checkpoint through cyclin B1,transcriptional activator through acetylation of
    transactivation site by CREBBP binding MDM2 resulting in transcriptional silencing and ubiquitin/proteasome
    dependent degradation of p53,activated by conjugation to UBL1 (SUMO1),putative up-regulated c-MYC target
    gene,putative teratologic suppressor gene and modulator of TFIIH (GTF2H),associated in nucleotide excision
    repair,activated by ATM in association with 14.3.3 proteins (YWHA*),tumor suppressor gene (see TSG17A),mutated in
    cancers such as pancreas and endometrial carcinomas,in Barrett's adenocarcinoma (and esophageal squamous cell
    carcinoma),in hepatocellular carcinoma with poor prognosis

         Gene Ontology (GO): 5/28 molecular function terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0001085RNA polymerase II transcription factor binding IPI18549481
    GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA17146433
    GO:0002020protease binding IPI11923872
    GO:0002039p53 binding IBA--
         
    TP53 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for TP53:
     Decreased viability of wild-ty  Enable proliferation in B-Raf   Increased cell death HMECs cel  Increased resistance to MDM2 i 

         15/27 MGI mutant phenotypes (inferred from 65 alleles(MGI details for Trp53) (see all 27):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    TP53 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TP53: Trp53tm1Mlh Trp53tm3Wahl Trp53tm5Wahl Trp53tm2Wahl Trp53tm1Tyj Trp53tm1Mok
                                                         Trp53tm1.1Brn Trp53tm1Brd Trp53tm1Sia

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TP53 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TP53

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TP53 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TP53 

    10/1911 SABiosciences Target genes for TP53 (see all 1911):
    AATF ABCC3 ABCC6P2 ABCD1 ABCF1 ABHD12 ABHD15 ABHD4 ABHD8 ABTB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TP53:
    hsa-mir-1285 (MIRT005474), hsa-mir-16 (MIRT005764), hsa-mir-125a-5p (MIRT004071), hsa-mir-25 (MIRT005417), hsa-mir-221 (MIRT005785), hsa-mir-15a (MIRT005763), hsa-mir-612 (MIRT005476), hsa-mir-222 (MIRT005786), hsa-mir-125b (MIRT000535), hsa-mir-30d (MIRT005418)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TP53
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate TP53 (see all 17):
    hsa-miR-576-3p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-98 hsa-miR-22
    SwitchGear 3'UTR luciferase reporter plasmidTP53 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TP53

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TP53
    Sirion Biotech Validated adenovirus to knockdown TP53 in human, mouse 
                         Customized adenovirus for overexpression of TP53

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for TP53
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    GenScript: all cDNA clones in your preferred vector (see all 7): TP53 (NM_000546)
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TP53 About   (see all 105)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glioma
    Glioma0.51
    Prostate cancer0.39
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    Melanoma0.43
    Bladder cancer0.31
    2Endometrial cancer
    Endometrial cancer0.45
    Colorectal cancer0.42
    Signal transduction PTEN pathway0.45
    3Development HGF signaling pathway
    Development Neurotrophin family signaling0.45
    Neurotrophin signaling pathway0.36
    Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    4Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    5MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/16 EMD Millipore Pathways for TP53 (see all 16)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Proteolysis Putative SUMO-1 pathway
    Immune response MIF in innate immunity response
    DNA damage DNA-damage-induced responses
    DNA damage Role of SUMO in p53 regulation

    2 R&D Systems Pathways for TP53
        Apoptosis Signaling Pathways
    Akt Signaling Pathway

    5/41 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TP53 (see all 41)
        Telomerase Components in Cell Signaling
    UVB-Induced MAPK Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer
    TRKA Signaling

    2 Cell Signaling Technology (CST) Pathways for TP53
        Cell Cycle / Checkpoint Control
    DNA Damage

    4 Tocris Bioscience Pathways for TP53
        Akt Pathway
    Apoptosis Pathway
    MAPK Pathway
    mTOR Pathway

    5/13 GeneGo (Thomson Reuters) Pathways for TP53 (see all 13)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Immune response MIF in innate immunity response
    Transcription P53 signaling pathway
    Development Neurotrophin family signaling
    Signal transduction AKT signaling

    5/36 BioSystems Pathways for TP53 (see all 36)
        MAPK signaling pathway
    DNA damage response
    Apoptosis
    Fluoropyrimidine Activity
    Senescence and Autophagy

    3 Sino Biological Pathways for TP53 
        EGFR Signaling Pathway
    p53 Pathway
    Death Receptor Signaling

    5/9        Reactome Pathways for TP53 (see all 9)
        Hemostasis
    Stabilization of p53
    Cell Cycle
    G1/S DNA Damage Checkpoints
    p53-Dependent G1 DNA Damage Response

    2 PharmGKB Pathways for TP53
        Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
    Fluoropyrimidine Pathway, Pharmacodynamics

    5/32         Kegg Pathways  (Kegg details for TP53) (see all 32):
        MAPK signaling pathway
    Cell cycle
    p53 signaling pathway
    PI3K-Akt signaling pathway
    Apoptosis


    TP53 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TP53

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    707/930 Interacting proteins for TP53 (P046371, 2, 3 ENSP000002693054) via UniProtKB, MINT, STRING, and/or I2D (see all 930) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009871, 2, 3, ENSP000004172814EBI-366083,EBI-389668 MINT-6540920 MINT-4793511 MINT-6823775 MINT-7013943 MINT-8303857 MINT-6540905 MINT-68742 MINT-8385459 MINT-56681 MINT-8374464 MINT-58468 MINT-7013791 MINT-68743 MINT-7013956 MINT-4545014 MINT-8339574 MINT-4049631 MINT-6540776 MINT-6801380 MINT-8374452 MINT-58465 MINT-7013688 MINT-7013802 MINT-4303990 MINT-8339590 MINT-6665330 MINT-4793467 MINT-8380636 MINT-4049616 MINT-4054304 MINT-7905142 MINT-8385480 MINT-7013780 MINT-6540889 MINT-8385531 MINT-8385552 MINT-8385886 MINT-8388795 MINT-8415355 MINT-6540807 MINT-8391984 MINT-7905326 MINT-6540796 I2D: score=12 STRING: ENSP00000417281
    HNRNPUL1Q9BUJ21, 2, 3, ENSP000003758634EBI-366083,EBI-1018153 MINT-58678 MINT-58677 MINT-58673 MINT-58674 MINT-58676 MINT-58675 MINT-8415355 MINT-58672 I2D: score=3 STRING: ENSP00000375863
    UBCP0CG482, 3, ENSP000003448184MINT-7220023 MINT-4051326 MINT-4304004 MINT-4054804 MINT-4304143 MINT-6801380 MINT-6615153 MINT-6541035 MINT-7299234 MINT-7298704 MINT-6799774 MINT-7013815 MINT-4052207 MINT-7219995 MINT-5114741 I2D: score=5 STRING: ENSP00000344818
    ENSG00000237724P081073, ENSP000004063594I2D: score=3 STRING: ENSP00000406359
    HSPA1AP081073, ENSP000003648024I2D: score=3 STRING: ENSP00000364802
    EP300Q094721, 2, 3, ENSP000002632534EBI-366083,EBI-447295 MINT-69507 MINT-8152513 MINT-8152530 MINT-8392126 MINT-2830826 MINT-7263630 MINT-6628507 MINT-8152544 I2D: score=7 STRING: ENSP00000263253
    PSME3P612892, 3, ENSP000002933624MINT-6540807 MINT-6540940 MINT-6540866 MINT-6540920 MINT-6540876 MINT-6540776 MINT-6541016 MINT-6540960 MINT-6540796 I2D: score=3 STRING: ENSP00000293362
    ENSG00000212866P081073I2D: score=3 
    ENSG00000215328P081073I2D: score=3 
    ENSG00000224501P081073I2D: score=3 
    ENSG00000231555P081073I2D: score=3 
    ENSG00000232804P081073I2D: score=3 
    ENSG00000234475P081073I2D: score=3 
    ENSG00000235941P081073I2D: score=3 
    HSPA1BP081073I2D: score=3 
    MDM4O151511, 2, 3, ENSP000003561504EBI-366083,EBI-398437 MINT-7291988 MINT-7292025 MINT-7291962 MINT-2517887 MINT-7291975 MINT-7896820 MINT-7896835 I2D: score=7 STRING: ENSP00000356150
    MKRN1Q9UHC72, 3, ENSP000002559774MINT-7298755 MINT-7298834 MINT-7298907 MINT-7298873 MINT-7298815 MINT-7298791 MINT-7298847 MINT-7298737 I2D: score=1 STRING: ENSP00000255977
    -Q9PST71EBI-366083,EBI-1782562 EBI-366083,EBI-617698 MINT-69740 MINT-6628483 MINT-6733190 MINT-69730 MINT-73318 MINT-6628495 MINT-6628706 MINT-6733198 MINT-73205 MINT-7277322 MINT-73319 MINT-6627917 MINT-6628699 MINT-5162111 MINT-6628692
    USP7Q930091, 2, 3, ENSP000003435354EBI-366083,EBI-302474 MINT-4304022 MINT-14904 MINT-15878 MINT-15877 MINT-8415355 MINT-15876 I2D: score=6 STRING: ENSP00000343535
    PIN1Q135261, 2, 3, ENSP000002479704EBI-366083,EBI-714158 MINT-19991 MINT-19990 MINT-8266557 MINT-19916 MINT-19915 I2D: score=4 STRING: ENSP00000247970
    ENSG00000206206Q9UER71, 2, 3EBI-366083,EBI-77321 MINT-2574339 I2D: score=5 
    ENSG00000206279Q9UER71, 2, 3EBI-366083,EBI-77321 MINT-2574339 I2D: score=5 
    ENSG00000227046Q9UER71, 2, 3EBI-366083,EBI-77321 MINT-2574339 I2D: score=5 
    ENSG00000231617Q9UER71, 2, 3EBI-366083,EBI-77321 MINT-2574339 I2D: score=5 
    HSPA9P386461, 2, 3, ENSP000002971854EBI-366083,EBI-354932 MINT-4302632 MINT-7557611 MINT-7557644 MINT-7557580 I2D: score=5 STRING: ENSP00000297185
    CREBBPQ927931, 2, 3, ENSP000002623674EBI-366083,EBI-81215 MINT-6665320 MINT-6665337 I2D: score=7 STRING: ENSP00000262367
    PARP1P098741, 2, 3, ENSP000003557594EBI-366083,EBI-355676 MINT-16978 MINT-16977 I2D: score=5 STRING: ENSP00000355759
    CUL9Q8IWT31, 2, 3, ENSP000002520504EBI-366083,EBI-311123 MINT-8415355 I2D: score=5 STRING: ENSP00000252050
    UBE3AQ050861, 2, 3, ENSP000003810454EBI-366083,EBI-954357 MINT-6628330 I2D: score=4 STRING: ENSP00000381045
    CUL7Q149991, 2, 3, ENSP000002653484EBI-366083,EBI-308606 MINT-8415355 I2D: score=2 STRING: ENSP00000265348
    PPP1R13LQ8WUF51, 2, 3, ENSP000003542184EBI-366083,EBI-5550163 MINT-8152544 I2D: score=2 STRING: ENSP00000354218
    BTBD2Q9BX701, 2, 3EBI-366083,EBI-710091 MINT-65379 I2D: score=5 
    OTUB1Q96FW12, 3MINT-8380020 MINT-8380061 MINT-8380636 MINT-8380008 MINT-8380032 MINT-8388795 MINT-8380053 MINT-8388765 I2D: score=1 
    ARIH2O953762, 3, ENSP000003487694MINT-8385595 MINT-8385459 MINT-8385531 MINT-8385886 MINT-8385510 MINT-63290 I2D: score=5 STRING: ENSP00000348769
    PLK1P533502, 3, ENSP000003000934MINT-2634858 MINT-7266250 MINT-8415512 MINT-2634822 MINT-2634880 MINT-2634842 I2D: score=2 STRING: ENSP00000300093
    GTF2H1P327802, 3, ENSP000002659634MINT-6544200 MINT-6544239 MINT-6544220 MINT-6544181 MINT-6544161 I2D: score=4 STRING: ENSP00000265963
    TPT1P136932, 3, ENSP000003683504MINT-8057126 MINT-8057107 MINT-8057141 MINT-8057116 MINT-8057160 I2D: score=2 STRING: ENSP00000368350
    BHLHE40O145032, 3, ENSP000002564954MINT-4544966 MINT-4545030 MINT-4654062 MINT-4545046 MINT-4544983 I2D: score=1 STRING: ENSP00000256495
    ENSG00000234258P349312, 3, ENSP000003964864MINT-4302642 I2D: score=2 STRING: ENSP00000396486
    RYBPQ8N4882, 3, ENSP000004194944MINT-7013916 MINT-7013688 MINT-7013780 MINT-7013930 I2D: score=2 STRING: ENSP00000419494
    ZNF420Q8TAQ52, 3, ENSP000003387704MINT-7989670 MINT-7989584 MINT-7989724 MINT-7989773 I2D: score=2 STRING: ENSP00000338770
    SP1P080472, 3, ENSP000003293574MINT-56525 MINT-56523 MINT-56524 I2D: score=6 STRING: ENSP00000329357
    GSK3BP498412, 3, ENSP000003248064MINT-4793219 MINT-4793253 MINT-8257746 I2D: score=5 STRING: ENSP00000324806
    MED1Q156482, 3, ENSP000003006514MINT-58470 MINT-58467 MINT-58464 I2D: score=4 STRING: ENSP00000300651
    ENSG00000206383P349312, 3MINT-4302642 I2D: score=2 
    ENSG00000236251P349312, 3MINT-4302642 I2D: score=2 
    HSPA1LP349312, 3MINT-4302642 I2D: score=2 
    MT1AP047312, 3, ENSP000002907054MINT-1781444 MINT-1781494 MINT-1781525 I2D: score=1 STRING: ENSP00000290705
    TOE1Q96GM82, 3, ENSP000003611624MINT-7144884 MINT-7144912 MINT-7144895 I2D: score=1 STRING: ENSP00000361162
    YWHAEP622582, 3, ENSP000002643354MINT-8008686 MINT-8008665 MINT-8008672 I2D: score=1 STRING: ENSP00000264335
    UBE2IP632792, 3, ENSP000003248974MINT-50578 MINT-50579 I2D: score=6 STRING: ENSP00000324897
    BRCA1P383982, 3, ENSP000003502834MINT-16162 MINT-16161 I2D: score=5 STRING: ENSP00000350283
    DVL2O146412, 3, ENSP000000053404MINT-67597 MINT-2858243 I2D: score=5 STRING: ENSP00000005340
    TK1P041832, 3, ENSP000003016344MINT-63365 MINT-8274236 I2D: score=5 STRING: ENSP00000301634
    NCLP193382, 3, ENSP000003181954MINT-8292070 MINT-8292213 I2D: score=4 STRING: ENSP00000318195
    YWHAZP631042, 3, ENSP000003095034MINT-74925 MINT-8415355 I2D: score=4 STRING: ENSP00000309503
    SMN1Q166372, 3, ENSP000003700834MINT-8271608 I2D: score=3 STRING: ENSP00000370083
    SFNP319472, 3, ENSP000003409894MINT-7711931 MINT-7711943 I2D: score=2 STRING: ENSP00000340989
    MAGEA2BP433561, 3, ENSP000003334874EBI-366083,EBI-5650739 I2D: score=1 STRING: ENSP00000333487
    S100A1P232972, 3, ENSP000002921694MINT-7905174 MINT-7905308 I2D: score=1 STRING: ENSP00000292169
    SNAI1O958632, 3, ENSP000002440504MINT-7718928 MINT-7718917 I2D: score=1 STRING: ENSP00000244050
    USP42Q9H9J42, 3, ENSP000003019624MINT-8303846 MINT-8303829 I2D: score=1 STRING: ENSP00000301962
    BCL2L1Q078172, 3, ENSP000003025644MINT-8249399 I2D: score=6 STRING: ENSP00000302564
    PIAS1O759251, 3, ENSP000002496364EBI-366083,EBI-629434 I2D: score=6 STRING: ENSP00000249636
    TOPORSQ9NS562, 3, ENSP000003537354MINT-4329805 I2D: score=6 STRING: ENSP00000353735
    CDKN2CP427732, 3, ENSP000002626624MINT-63749 I2D: score=5 STRING: ENSP00000262662
    COX17Q140612, 3, ENSP000002610704MINT-64164 I2D: score=5 STRING: ENSP00000261070
    EGR1P181462, 3, ENSP000002399384MINT-4793180 I2D: score=5 STRING: ENSP00000239938
    EIF2S2P200422, 3, ENSP000003641194MINT-63537 I2D: score=5 STRING: ENSP00000364119
    HTTP428581, 3, ENSP000003471844EBI-366083,EBI-466029 I2D: score=5 STRING: ENSP00000347184
    S100A8P051092, 3, ENSP000003577214MINT-63391 I2D: score=5 STRING: ENSP00000357721
    TP63Q9H3D41, 3, ENSP000002647314EBI-366083,EBI-2337775 I2D: score=5 STRING: ENSP00000264731
    HIPK2Q9H2X62, 3MINT-68744 MINT-60094 I2D: score=4 
    ING1Q9UK532, 3, ENSP000003649294MINT-6615153 I2D: score=4 STRING: ENSP00000364929
    NFYAP235111, 3, ENSP000003457024EBI-366083,EBI-389739 I2D: score=4 STRING: ENSP00000345702
    WRNQ141911, 3, ENSP000002981394EBI-366083,EBI-368417 I2D: score=4 STRING: ENSP00000298139
    DDX5P178441, 3, ENSP000002257924EBI-366083,EBI-351962 I2D: score=3 STRING: ENSP00000225792
    EEF2P136392, 3, ENSP000003079404MINT-8415355 I2D: score=3 STRING: ENSP00000307940
    IKBKBO149202, 3, ENSP000003391514MINT-7295816 I2D: score=3 STRING: ENSP00000339151
    ING4Q9UNL42, 3, ENSP000003800244MINT-50659 I2D: score=3 STRING: ENSP00000380024
    PPP1CAP621362, 3, ENSP000003260314MINT-62206 I2D: score=3 STRING: ENSP00000326031
    SETD7Q8WTS61, 3, ENSP000002740314EBI-366083,EBI-1268586 I2D: score=3 STRING: ENSP00000274031
    CEBPBP176761, 3, ENSP000003054224EBI-366083,EBI-969696 I2D: score=2 STRING: ENSP00000305422
    FBXO11Q86XK21, 3, ENSP000003238224EBI-366083,EBI-1047804 I2D: score=2 STRING: ENSP00000323822
    HSPA5P110212, 3, ENSP000003241734MINT-4052873 I2D: score=2 STRING: ENSP00000324173
    KAT8Q9H7Z62, 3, ENSP000004060374MINT-1897583 I2D: score=2 STRING: ENSP00000406037
    MAPK11Q157591, 3, ENSP000003336854EBI-366083,EBI-298304 I2D: score=2 STRING: ENSP00000333685
    USP29Q9HBJ72, 3, ENSP000002541814MINT-8145730 I2D: score=2 STRING: ENSP00000254181
    COPS4Q9BT782, 3, ENSP000002643894MINT-8415355 I2D: score=1 STRING: ENSP00000264389
    CSE1LP550601, 3, ENSP000002629824EBI-366083,EBI-286709 I2D: score=1 STRING: ENSP00000262982
    DYNC1I1O145762, 3, ENSP000003201304MINT-1891331 I2D: score=1 STRING: ENSP00000320130
    KDM1AO603412, 3, ENSP000003490494MINT-8415512 I2D: score=1 STRING: ENSP00000349049
    MAGEA2P433561, 3EBI-366083,EBI-5650739 I2D: score=1 
    PAGR1Q9BTK62, 3, ENSP000003265194MINT-7013631 I2D: score=1 STRING: ENSP00000326519
    PPP2R5CQ133622, 3, ENSP000003339054MINT-4299201 I2D: score=1 STRING: ENSP00000333905
    S100A6P067032, 3, ENSP000003577084MINT-7905207 I2D: score=1 STRING: ENSP00000357708
    TP53P046371, 2EBI-366083,EBI-366083 MINT-6628330 MINT-8415355
    CCL18P557742, 3MINT-63883 I2D: score=6 
    ANXA3P124292, 3MINT-63460 I2D: score=5 
    ARL3P364052, 3MINT-63694 I2D: score=5 
    ERHP840902, 3MINT-64020 I2D: score=5 
    FXYD6Q9H0Q32, 3MINT-65439 I2D: score=5 
    MAD2L1BPQ150132, 3MINT-64188 I2D: score=5 
    MPHOSPH6Q995472, 3MINT-65272 I2D: score=5 
    PAFAH1B3Q151022, 3MINT-64202 I2D: score=5 
    PNPP004912, 3MINT-63335 I2D: score=5 
    PSMD11O002312, 3MINT-63023 I2D: score=5 
    RAB4AP203382, 3MINT-63547 I2D: score=5 
    SAT1P216732, 3MINT-63559 I2D: score=5 
    SERPINB9P504532, 3MINT-63814 I2D: score=5 
    STX5Q131902, 3MINT-64119 I2D: score=5 
    SULT1E1P498882, 3MINT-63800 I2D: score=5 
    THAP8Q8NA922, 3MINT-64946 I2D: score=5 
    ZCCHC10Q8TBK62, 3MINT-65034 I2D: score=5 
    ZNF24P170282, 3MINT-63497 I2D: score=5 
    MAPKAPK5Q8IW411, 3EBI-366083,EBI-1201460 I2D: score=4 
    PCDHA4Q9UN742, 3MINT-65770 I2D: score=4 
    PPA1Q151812, 3MINT-64729 I2D: score=4 
    DLEU1O432612, 3MINT-63114 I2D: score=3 
    GUSBP1Q154862, 3MINT-64247 I2D: score=3 
    KIAA0087Q146952, 3MINT-64748 I2D: score=3 
    SCAMP1O151262, 3MINT-2866927 I2D: score=3 
    ANXA7P200732, 3MINT-8248834 I2D: score=2 
    MLL5Q8IZD21, 3EBI-366083,EBI-2689959 I2D: score=2 
    RAP1BP612242, 3MINT-8268163 I2D: score=2 
    UFD1LQ928902, 3MINT-8276859 I2D: score=2 
    RPS27AP629792, 3MINT-8415355 I2D: score=1 
    XPO1O149802, 3MINT-4303978 I2D: score=1 
    ENSG00000206481Q146763, ENSP000003730604I2D: score=3 STRING: ENSP00000373060
    MDC1Q146763, ENSP000003655884I2D: score=3 STRING: ENSP00000365588
    YWHAGP619812, 3, ENSP000003063304MINT-8008651 MINT-8008679 MINT-8009392 MINT-8008658 MINT-8009385 MINT-8415355 MINT-8009378 I2D: score=2 STRING: ENSP00000306330
    DAXXQ9UER71, 2, 3, ENSP000003968764EBI-366083,EBI-77321 MINT-2574339 I2D: score=5 STRING: ENSP00000396876 STRING: ENSP00000266000
    ENSG00000224587Q146763I2D: score=3 
    ENSG00000225589Q146763I2D: score=3 
    ENSG00000228575Q146763I2D: score=3 
    ENSG00000231135Q146763I2D: score=3 
    ENSG00000234012Q146763I2D: score=3 
    ENSG00000237095Q146763I2D: score=3 
    ENSG00000224774P678703, ENSP000004156154I2D: score=2 STRING: ENSP00000415615
    CSNK2BP678703, ENSP000003650254I2D: score=2 STRING: ENSP00000365025
    MAP1BP468212, 3, ENSP000002967554MINT-6701791 MINT-6701342 MINT-6702266 MINT-6706444 MINT-6700861 MINT-6702529 I2D: score=1 STRING: ENSP00000296755
    NR4A1P227362, 3, ENSP000002430504MINT-4049673 MINT-4049689 MINT-4049732 MINT-4049598 MINT-4049708 MINT-4049650 I2D: score=3 STRING: ENSP00000243050
    ENSG00000206406P678703I2D: score=2 
    ENSG00000224398P678703I2D: score=2 
    ENSG00000228875P678703I2D: score=2 
    ENSG00000230700P678703I2D: score=2 
    ENSG00000232960P678703I2D: score=2 
    HDAC1Q135471, 2, 3, ENSP000003626494EBI-366083,EBI-301834 MINT-7893049 MINT-7893085 MINT-7893074 MINT-7893061 I2D: score=5 STRING: ENSP00000362649
    RCHY1Q96PM52, 3, ENSP000003212394MINT-5114673 MINT-5114653 MINT-5114724 MINT-5114627 MINT-5114708 I2D: score=4 STRING: ENSP00000321239
    NPM1P067481, 2, 3, ENSP000002969304EBI-366083,EBI-78579 MINT-74886 MINT-8391984 MINT-74887 MINT-74888 I2D: score=6 STRING: ENSP00000296930
    SYVN1Q86TM62, 3, ENSP000003663954MINT-4052116 MINT-4052176 MINT-4052156 MINT-4052135 MINT-4052187 I2D: score=3 STRING: ENSP00000366395
    ENSG00000227333Q96KQ73, ENSP000003973234I2D: score=1 STRING: ENSP00000397323
    EHMT2Q96KQ73I2D: score=1 
    ENSG00000206376Q96KQ73I2D: score=1 
    ENSG00000232045Q96KQ73I2D: score=1 
    ENSG00000236759Q96KQ73I2D: score=1 
    ENSG00000238134Q96KQ73I2D: score=1 
    BCL2P104151, 2, 3, ENSP000003296234EBI-366083,EBI-77694 MINT-7291988 MINT-7292025 MINT-7291975 I2D: score=2 STRING: ENSP00000329623
    RFWD2Q8NHY22, 3, ENSP000003566414MINT-49847 MINT-49845 MINT-49846 MINT-49844 I2D: score=4 STRING: ENSP00000356641
    WWOXQ9NZC72, 3, ENSP000003861614MINT-61317 MINT-61316 MINT-61314 MINT-61311 I2D: score=5 STRING: ENSP00000386161
    HNRNPKP619782, 3, ENSP000003654394MINT-8200651 MINT-8409198 MINT-8201449 MINT-8201427 I2D: score=1 STRING: ENSP00000365439
    NRD1O438472MINT-8415621 MINT-8415512 MINT-8415713 MINT-8415610 MINT-8415694 MINT-8415680
    SAFBQ154242, ENSP000002921234MINT-8072012 MINT-8074581 MINT-8074790 MINT-8072027 MINT-8072038 STRING: ENSP00000292123
    ENSG00000234876Q994663, ENSP000004034474I2D: score=1 STRING: ENSP00000403447
    PMLP295901, 2, 3, ENSP000002680584EBI-366083,EBI-295890 MINT-4793489 MINT-4793478 I2D: score=5 STRING: ENSP00000268058
    CHEK2O960172, 3, ENSP000003720234MINT-13742 MINT-58603 MINT-6806523 I2D: score=4 STRING: ENSP00000372023
    S100A4P264472, 3, ENSP000003462944MINT-7905196 MINT-7256502 MINT-7905358 I2D: score=4 STRING: ENSP00000346294
    BANPQ8N9N52, 3, ENSP000003769034MINT-7893049 MINT-7893107 MINT-7893094 I2D: score=3 STRING: ENSP00000376903
    ENSG00000223355Q994663I2D: score=1 
    ENSG00000238196Q994663I2D: score=1 
    NOTCH4Q994663I2D: score=1 
    CDKN1AP389362, 3, ENSP000002447414MINT-8252340 MINT-1891378 I2D: score=3 STRING: ENSP00000244741
    TP53BP2Q136252, 3, ENSP000003419574MINT-8152530 MINT-24859 I2D: score=6 STRING: ENSP00000341957
    CDKN2AQ8N7262, 3, ENSP000003551534MINT-8415355 I2D: score=3 MINT-7989724 STRING: ENSP00000355153
    TBPP202261, 2, 3, ENSP000002303544EBI-366083,EBI-355371 MINT-69726 I2D: score=3 STRING: ENSP00000230354
    PTK2Q053971, 2, 3, ENSP000003411894EBI-366083,EBI-702142 MINT-7294020 I2D: score=4 STRING: ENSP00000341189
    S100BP042712, 3, ENSP000002917004MINT-7905162 MINT-7905317 I2D: score=3 STRING: ENSP00000291700
    S100A2P290342, 3, ENSP000003576974MINT-7905347 MINT-7905185 I2D: score=3 STRING: ENSP00000357697
    TAF9Q165943, ENSP000003702014I2D: score=3 STRING: ENSP00000370201 STRING: ENSP00000217893
    MAGEB18Q96M612, 3, ENSP000003145434MINT-66234 MINT-2879329 I2D: score=4 STRING: ENSP00000314543
    CCDC106Q9BWC92, 3, ENSP000003096814MINT-7681390 MINT-7681212 I2D: score=5 STRING: ENSP00000309681
    HSPB1P047922, 3, ENSP000002485534MINT-4302652 MINT-65132 I2D: score=5 STRING: ENSP00000248553
    SMN2Q166372, 3, ENSP000003701194MINT-8271608 I2D: score=3 STRING: ENSP00000370119
    CEBPZQ037012, 3, ENSP000002341704MINT-45889 MINT-45888 I2D: score=5 STRING: ENSP00000234170
    NAP1L1P552092, 3, ENSP000002611824MINT-72857 MINT-72858 I2D: score=1 STRING: ENSP00000261182
    SRPK1Q96SB42, ENSP000003910694MINT-8074754 MINT-8074706 MINT-8074644 STRING: ENSP00000391069
    PPP2R1AP301532, 3, ENSP000003248044MINT-4299110 MINT-4299098 I2D: score=1 STRING: ENSP00000324804
    CCT5P486432, 3, ENSP000002803264MINT-63773 MINT-8415355 I2D: score=5 STRING: ENSP00000280326
    NR0B2Q154662, ENSP000002542274MINT-8331203 MINT-8331211 MINT-8339604 STRING: ENSP00000254227
    ATMQ133152, 3, ENSP000002786164MINT-49767 I2D: score=6 STRING: ENSP00000278616
    NEDD8Q158432, 3, ENSP000002504954MINT-8415355 I2D: score=3 STRING: ENSP00000250495
    SIRT1Q96EB61, 3, ENSP000002120154EBI-366083,EBI-1802965 I2D: score=4 STRING: ENSP00000212015
    TP53BP1Q128882, 3, ENSP000003714754MINT-8415355 I2D: score=5 STRING: ENSP00000371475
    CHEK1O147572, 3, ENSP000002789164MINT-1958329 I2D: score=3 STRING: ENSP00000278916
    KAT5Q929931, 3, ENSP000003403304EBI-366083,EBI-399080 I2D: score=3 STRING: ENSP00000340330
    MAPK8P459832, 3, ENSP000003534834MINT-61312 I2D: score=5 STRING: ENSP00000353483
    BLMP541322, 3, ENSP000003472324MINT-8415512 I2D: score=4 STRING: ENSP00000347232
    RAD51Q066091, 3, ENSP000002678684EBI-366083,EBI-297202 I2D: score=3 STRING: ENSP00000267868
    SIN3AQ96ST31, 3, ENSP000003536224EBI-366083,EBI-347218 I2D: score=6 STRING: ENSP00000353622
    PHBP352322, 3, ENSP000003004084MINT-7717378 I2D: score=5 STRING: ENSP00000300408
    GADD45AP245222, 3, ENSP000003600254MINT-8256081 I2D: score=2 STRING: ENSP00000360025
    ARP102752, 3, ENSP000003638224MINT-7103733 I2D: score=2 STRING: ENSP00000363822
    PBKQ96KB51, 3, ENSP000003019054EBI-366083,EBI-536853 I2D: score=3 STRING: ENSP00000301905
    ING2Q9H1602, 3, ENSP000003071834MINT-2830804 I2D: score=1 STRING: ENSP00000307183
    NOC2LQ9Y3T91, 3, ENSP000003179924EBI-366083,EBI-751547 I2D: score=1 STRING: ENSP00000317992
    PIAS4Q8N2W91, 3, ENSP000002629714EBI-366083,EBI-473160 I2D: score=4 STRING: ENSP00000262971
    KMT2EQ8IZD21, 3, ENSP000002577454EBI-366083,EBI-2689959 I2D: score=2 STRING: ENSP00000257745
    DUSP26Q9BV471, 3, ENSP000002562614EBI-366083,EBI-2924519 I2D: score=2 STRING: ENSP00000256261
    HDAC8Q9BY412, 3, ENSP000003626744MINT-5207405 I2D: score=1 STRING: ENSP00000362674
    HIPK1Q86Z021, 3, ENSP000003585714EBI-366083,EBI-692891 I2D: score=4 STRING: ENSP00000358571
    MTORP423452, 3, ENSP000003545584MINT-7222784 I2D: score=1 STRING: ENSP00000354558
    RASGRF1Q139722, 3, ENSP000004059634MINT-2634790 I2D: score=1 STRING: ENSP00000405963
    SAE1Q9UBE02, 3, ENSP000002702254MINT-50577 I2D: score=1 STRING: ENSP00000270225
    XRCC6P129561, 3, ENSP000003522574EBI-366083,EBI-353208 I2D: score=5 STRING: ENSP00000352257
    BMXP518132, 3, ENSP000003087744MINT-68565 I2D: score=2 STRING: ENSP00000308774
    HUWE1Q7Z6Z71, 3, ENSP000002628544EBI-366083,EBI-625934 I2D: score=5 STRING: ENSP00000262854
    NMT1P304192, 3, ENSP000002589604MINT-1795431 I2D: score=2 STRING: ENSP00000258960
    PPP2R2AP631512, 3, ENSP000003701134MINT-4299164 I2D: score=1 STRING: ENSP00000370113
    RPL5P467772, 3, ENSP000003593454MINT-8415355 I2D: score=1 STRING: ENSP00000359345
    ENSG00000225553O431893, ENSP000003919014I2D: score=1 STRING: ENSP00000391901
    NMT2O605512, 3, ENSP000003674074MINT-1795395 I2D: score=2 STRING: ENSP00000367407
    VDRP114731, 3, ENSP000002290224EBI-366083,EBI-286357 I2D: score=2 STRING: ENSP00000229022
    UHRF2Q96PU41, 3, ENSP000002768934EBI-366083,EBI-625304 I2D: score=1 STRING: ENSP00000276893
    SNURFQ9Y6752, 3, ENSP000003365434MINT-65860 I2D: score=1 STRING: ENSP00000336543
    GSTM4Q030132, 3, ENSP000003588514MINT-64041 I2D: score=5 STRING: ENSP00000358851
    RCC1P187542, 3, ENSP000003629374MINT-8268515 I2D: score=2 STRING: ENSP00000362937
    MPDZO759702MINT-8415632 MINT-8415643 MINT-8415512
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    HMGB1P094293, ENSP000003430404I2D: score=6 STRING: ENSP00000343040
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    HIF1AQ166653, ENSP000003380184I2D: score=5 STRING: ENSP00000338018
    ABL1P005193, ENSP000003614234I2D: score=4 STRING: ENSP00000361423
    CDC42P609533, ENSP000003144584I2D: score=4 STRING: ENSP00000314458
    E2F1Q010943, ENSP000003455714I2D: score=4 STRING: ENSP00000345571
    KAT2BQ928313, ENSP000002637544I2D: score=4 STRING: ENSP00000263754
    MAPK1P284823, ENSP000002158324I2D: score=4 STRING: ENSP00000215832
    MAPK9P459843, ENSP000003214104I2D: score=4 STRING: ENSP00000321410
    RPA1P276943, ENSP000002547194I2D: score=4 STRING: ENSP00000254719
    VRK1Q999863, ENSP000002166394I2D: score=4 STRING: ENSP00000216639
    YBX1P678093, ENSP000003616264I2D: score=4 STRING: ENSP00000361626
    AK6Q165943I2D: score=3 
    CABLES1Q8TDN43, ENSP000002569254I2D: score=3 STRING: ENSP00000256925
    CARM1Q86X553, ENSP000003256904I2D: score=3 STRING: ENSP00000325690
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    CHD3Q128733, ENSP000003697164I2D: score=3 STRING: ENSP00000369716
    COPS5Q929053, ENSP000003505124I2D: score=3 STRING: ENSP00000350512
    EIF2AK2P195253, ENSP000002330574I2D: score=3 STRING: ENSP00000233057
    ELLP551993, ENSP000002628094I2D: score=3 STRING: ENSP00000262809
    ESR1P033723, ENSP000002062494I2D: score=3 STRING: ENSP00000206249
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    POLA1P098843, ENSP000003683494I2D: score=3 STRING: ENSP00000368349
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    PHF1O431893I2D: score=1 
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    RRM2BQ7LG563, ENSP000002518104I2D: score=2 STRING: ENSP00000251810
    SMYD2Q9NRG43, ENSP000003559244I2D: score=2 STRING: ENSP00000355924
    TADA3O755283, ENSP000003076844I2D: score=3 STRING: ENSP00000307684
    OTUD5Q96G743, ENSP000001560844I2D: score=2 STRING: ENSP00000156084
    TP53INP1Q96A563, ENSP000003442154I2D: score=4 STRING: ENSP00000344215
    CCNG1P519593, ENSP000003446354I2D: score=4 STRING: ENSP00000344635
    ATF3P188473, ENSP000003443524I2D: score=6 STRING: ENSP00000344352
    AURKAO149653, ENSP000002169114I2D: score=4 STRING: ENSP00000216911
    BRD7Q9NPI11, ENSP000003781804EBI-366083,EBI-711221 STRING: ENSP00000378180
    CSNK1A1P487293, ENSP000002617984I2D: score=3 STRING: ENSP00000261798
    ERCC3P194473, ENSP000002853984I2D: score=3 STRING: ENSP00000285398
    ERCC6Q034683, ENSP000003480894I2D: score=2 STRING: ENSP00000348089
    HSPA8P111423, ENSP000002273784I2D: score=2 STRING: ENSP00000227378
    IFI16Q166663, ENSP000003571134I2D: score=3 STRING: ENSP00000357113
    MSH2P432463, ENSP000002331464I2D: score=1 STRING: ENSP00000233146
    NFYBP252083, ENSP000002400554I2D: score=4 STRING: ENSP00000240055
    RFFLQ8WZ733, ENSP000003261704I2D: score=1 STRING: ENSP00000326170
    SP3Q024473, ENSP000003103014I2D: score=3 STRING: ENSP00000310301
    STK11Q158313, ENSP000003248564I2D: score=2 STRING: ENSP00000324856
    SUMO3P558543, ENSP000003303434I2D: score=1 STRING: ENSP00000330343
    TAF6P498483, ENSP000003445374I2D: score=1 STRING: ENSP00000344537
    TRRAPQ9Y4A53, ENSP000003477334I2D: score=1 STRING: ENSP00000347733
    TXNP105993, ENSP000003636414I2D: score=3 STRING: ENSP00000363641
    UBE2KP610863, ENSP000002614274I2D: score=1 STRING: ENSP00000261427
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    WT1P195443, ENSP000003313274I2D: score=3 STRING: ENSP00000331327
    CDK5Q005353, ENSP000002975184I2D: score=3 STRING: ENSP00000297518
    CDK9P507503, ENSP000003623614I2D: score=3 STRING: ENSP00000362361
    ITCHQ96J023, ENSP000003639984I2D: score=1 STRING: ENSP00000363998
    MAPK3P273613, ENSP000002630254I2D: score=4 STRING: ENSP00000263025
    RPS7P620813, ENSP000003390954I2D: score=2 STRING: ENSP00000339095
    TP53I3Q53FA73, ENSP000002387214I2D: score=1 STRING: ENSP00000238721
    BRCA2P515873, ENSP000003694974I2D: score=3 STRING: ENSP00000369497
    RNF20Q5VTR23, ENSP000003737724I2D: score=2 STRING: ENSP00000373772
    COPS2P612013, ENSP000002992594I2D: score=2 STRING: ENSP00000299259
    NFKBIAP259633, ENSP000002167974I2D: score=5 STRING: ENSP00000216797
    TP73O153503, ENSP000003675454I2D: score=3 STRING: ENSP00000367545
    SETD8Q9NQR13, ENSP000003329954I2D: score=1 STRING: ENSP00000332995
    BACH1O148673, ENSP000002868004I2D: score=1 STRING: ENSP00000286800
    USP39Q53GS93, ENSP000003129814I2D: score=2 STRING: ENSP00000312981
    WDR48Q8TAF33, ENSP000003074914I2D: score=2 STRING: ENSP00000307491
    MIFP141743, ENSP000002157544I2D: score=1 STRING: ENSP00000215754
    VHLP403373, ENSP000002564744I2D: score=1 STRING: ENSP00000256474
    ACTA1P681333, ENSP000003556454I2D: score=2 STRING: ENSP00000355645
    AIMP2Q131553, ENSP000002230294I2D: score=1 STRING: ENSP00000223029
    APEX1P276953, ENSP000002167144I2D: score=4 STRING: ENSP00000216714
    ARID3AQ998563, ENSP000002636204I2D: score=2 STRING: ENSP00000263620
    BRF1Q929943, ENSP000003290294I2D: score=3 STRING: ENSP00000329029
    BTKQ061873, ENSP000003081764I2D: score=1 STRING: ENSP00000308176
    CCNHP519463, ENSP000002568974I2D: score=3 STRING: ENSP00000256897
    CDC14AQ9UNH53, ENSP000003549164I2D: score=2 STRING: ENSP00000354916
    CDC14BO607293, ENSP000003643894I2D: score=2 STRING: ENSP00000364389
    CDC25CP303073, ENSP000003216564I2D: score=2 STRING: ENSP00000321656
    CHD8Q9HCK83, ENSP000004062884I2D: score=1 STRING: ENSP00000406288
    CHUKO151113, ENSP000003594244I2D: score=2 STRING: ENSP00000359424
    CREB1P162203, ENSP000003876994I2D: score=1 STRING: ENSP00000387699
    CSNK1DP487303, ENSP000003244644I2D: score=2 STRING: ENSP00000324464
    DHCR24Q153923, ENSP000003603164I2D: score=3 STRING: ENSP00000360316
    DNMT1P263583, ENSP000003525164I2D: score=1 STRING: ENSP00000352516
    EPHA3P293203, ENSP000003374514I2D: score=2 STRING: ENSP00000337451
    ETS1P149213, ENSP000003764364I2D: score=1 STRING: ENSP00000376436
    GNL3Q9BVP23, ENSP000003957724I2D: score=3 STRING: ENSP00000395772
    HABP4Q5JVS03, ENSP000003643984I2D: score=3 STRING: ENSP00000364398
    HIPK3Q9H4223, ENSP000003042264I2D: score=1 STRING: ENSP00000304226
    HNF4AP412353, ENSP000003129874I2D: score=2 STRING: ENSP00000312987
    HSP90AB1P082383, ENSP000003258754I2D: score=2 STRING: ENSP00000325875
    JMYQ8N9B53, ENSP000003794414I2D: score=1 STRING: ENSP00000379441
    KLF4O434743, ENSP000003638044I2D: score=2 STRING: ENSP00000363804
    KPNB1Q149743, ENSP000002901584I2D: score=2 STRING: ENSP00000290158
    MAPK10P537793, ENSP000003521574I2D: score=3 STRING: ENSP00000352157
    MNAT1P519483, ENSP000002612454I2D: score=3 STRING: ENSP00000261245
    MSL2Q9HCI73, ENSP000003118274I2D: score=1 STRING: ENSP00000311827
    MSX1P283603, ENSP000003721704I2D: score=4 STRING: ENSP00000372170
    NDNQ996083, ENSP000003326434I2D: score=2 STRING: ENSP00000332643
    NQO1P155593, ENSP000003197884I2D: score=2 STRING: ENSP00000319788
    PLAGL1Q9UM633, ENSP000003468104I2D: score=3 STRING: ENSP00000346810
    PRIM1P496423, ENSP000003504914I2D: score=2 STRING: ENSP00000350491
    PRKCAP172523, ENSP000002843844I2D: score=2 STRING: ENSP00000284384
    PTGS2P353543, ENSP000003564384I2D: score=3 STRING: ENSP00000356438
    PTTG1O959973, ENSP000003449364I2D: score=4 STRING: ENSP00000344936
    SAFB2Q141512, ENSP000002525424MINT-8074828 STRING: ENSP00000252542
    SERPINH1P504543, ENSP000003508944I2D: score=1 STRING: ENSP00000350894
    SHISA5Q8N1143, ENSP000002964444I2D: score=1 STRING: ENSP00000296444
    SSTR3P327453, ENSP000003301384I2D: score=1 STRING: ENSP00000330138
    TAF9BQ9HBM63, ENSP000003399174I2D: score=1 STRING: ENSP00000339917
    TDGQ135693, ENSP000003766114I2D: score=1 STRING: ENSP00000376611
    TECP426803, ENSP000003709124I2D: score=1 STRING: ENSP00000370912
    TFAP2AP055493, ENSP000003689244I2D: score=3 STRING: ENSP00000368924
    TFAP2CQ927543, ENSP000002010314I2D: score=3 STRING: ENSP00000201031
    TTKP339813, ENSP000002305104I2D: score=1 STRING: ENSP00000230510
    TWIST1Q156721, ENSP000002422614EBI-366083,EBI-1797287 STRING: ENSP00000242261
    UBR5O950713, ENSP000002209594I2D: score=1 STRING: ENSP00000220959
    UIMC1Q96RL13, ENSP000003664344I2D: score=1 STRING: ENSP00000366434
    USP10Q146943, ENSP000002194734I2D: score=1 STRING: ENSP00000219473
    ZMIZ2Q8NF643, ENSP000003117784I2D: score=1 STRING: ENSP00000311778
    ZMYND11Q153263, ENSP000003099924I2D: score=1 STRING: ENSP00000309992
    ZNF148Q9UQR13, ENSP000003538634I2D: score=3 STRING: ENSP00000353863
    ANKRD2Q9GZV13, ENSP000003061634I2D: score=2 STRING: ENSP00000306163
    AXIN1O151691, ENSP000002623204EBI-366083,EBI-710484 STRING: ENSP00000262320
    BAIAP2L1Q9UHR43, ENSP000000052604I2D: score=1 STRING: ENSP00000005260
    CCAR1Q8IX123, ENSP000002658724I2D: score=1 STRING: ENSP00000265872
    ETHE1O955713, ENSP000002921474I2D: score=1 STRING: ENSP00000292147
    FBXO42Q6P3S63, ENSP000003647424I2D: score=1 STRING: ENSP00000364742
    IGF1RP080693, ENSP000002680354I2D: score=1 STRING: ENSP00000268035
    KAT2AQ928303, ENSP000002259164I2D: score=1 STRING: ENSP00000225916
    MED21Q135033, ENSP000002828924I2D: score=1 STRING: ENSP00000282892
    NUAK1O602851, ENSP000002614024EBI-366083,EBI-1046789 STRING: ENSP00000261402
    PDLIM7Q9NR123, ENSP000003480994I2D: score=1 STRING: ENSP00000348099
    PSMD10O758323, ENSP000002179584I2D: score=1 STRING: ENSP00000217958
    SMURF1Q9HCE73, ENSP000003546214I2D: score=1 STRING: ENSP00000354621
    TAF1BQ53T943, ENSP000002636634I2D: score=2 STRING: ENSP00000263663
    TAF1CQ155723, ENSP000003678024I2D: score=2 STRING: ENSP00000367802
    AURKBQ96GD43, ENSP000003139504I2D: score=1 STRING: ENSP00000313950
    CCDC8Q9H0W52, ENSP000003031584MINT-8415355 STRING: ENSP00000303158
    CCNA2P202483, ENSP000002740264I2D: score=3 STRING: ENSP00000274026
    CR2P200233, ENSP000003560244I2D: score=2 STRING: ENSP00000356024
    FKBP3Q006883, ENSP000002163304I2D: score=1 STRING: ENSP00000216330
    G3BP1Q132833, ENSP000003485784I2D: score=1 STRING: ENSP00000348578
    G3BP2Q9UN863, ENSP000003527384I2D: score=1 STRING: ENSP00000352738
    GNL3LQ9NVN83, ENSP000003385734I2D: score=1 STRING: ENSP00000338573
    KANSL1Q7Z3B33, ENSP000002624194I2D: score=1 STRING: ENSP00000262419
    KAT6AQ927943, ENSP000002657134I2D: score=1 STRING: ENSP00000265713
    NUB1Q9Y5A73, ENSP000003986444I2D: score=1 STRING: ENSP00000398644
    PRKRIRO434223, ENSP000002600454I2D: score=1 STRING: ENSP00000260045
    RAD23AP547253, ENSP000003213654I2D: score=1 STRING: ENSP00000321365
    SMAD3P840223, ENSP000003329734I2D: score=2 STRING: ENSP00000332973
    STRA13A8MT693, ENSP000003029514STRING: ENSP00000302951 I2D: score=1 
    SUPT7LO948643, ENSP000003367504I2D: score=1 STRING: ENSP00000336750
    TADA1Q96BN23, ENSP000003568484I2D: score=1 STRING: ENSP00000356848
    TAF5LO755293, ENSP000002582814I2D: score=1 STRING: ENSP00000258281
    UBE4BO951553, ENSP000003430014I2D: score=1 STRING: ENSP00000343001
    TGFB1P011373, ENSP000002219304I2D: score=1 STRING: ENSP00000221930
    BREQ9NXR73, ENSP000003434124I2D: score=1 STRING: ENSP00000343412
    MAPK14Q165393, ENSP000002297944I2D: score=2 STRING: ENSP00000229794
    RNF40O751503, ENSP000003256774I2D: score=1 STRING: ENSP00000325677
    COPS3Q9UNS23, ENSP000002687174I2D: score=2 STRING: ENSP00000268717
    COPS7AQ9UBW83, ENSP000002292514I2D: score=2 STRING: ENSP00000229251
    COPS8Q996273, ENSP000003463404I2D: score=2 STRING: ENSP00000346340
    MAGEC2Q9UBF11, ENSP000003546604EBI-366083,EBI-5651487 STRING: ENSP00000354660
    AGO1Q9UL183, ENSP000003623004I2D: score=1 STRING: ENSP00000362300
    AGO2Q9UKV83, ENSP000002205924I2D: score=1 STRING: ENSP00000220592
    ASF1AQ9Y2943, ENSP000002295954I2D: score=1 STRING: ENSP00000229595
    BRD8Q9H0E93, ENSP000002549004I2D: score=1 STRING: ENSP00000254900
    DAB2IPQ5VWQ83, ENSP000002593714I2D: score=1 STRING: ENSP00000259371
    DPH1Q9BZG83, ENSP000002630834I2D: score=1 STRING: ENSP00000263083
    GTPBP4Q9BZE43, ENSP000003540404I2D: score=1 STRING: ENSP00000354040
    IGF2BP1Q9NZI83, ENSP000002903414I2D: score=1 STRING: ENSP00000290341
    MYL9P248443, ENSP000002790224I2D: score=1 STRING: ENSP00000279022
    NPRL3Q129803, ENSP000003828344I2D: score=1 STRING: ENSP00000382834
    SPSB1Q96BD63, ENSP000003302214I2D: score=1 STRING: ENSP00000330221
    TRAPPC11Q7Z3923, ENSP000003353714I2D: score=1 STRING: ENSP00000335371
    TTLL5Q6EMB23, ENSP000002988324I2D: score=1 STRING: ENSP00000298832
    MEN1O002553, ENSP000003370884I2D: score=1 STRING: ENSP00000337088
    RBBP5Q152913, ENSP000002645154I2D: score=1 STRING: ENSP00000264515
    WDR5P619643, ENSP000003514464I2D: score=1 STRING: ENSP00000351446
    PPP1CCP368733, ENSP000003350844I2D: score=2 STRING: ENSP00000335084
    DDB1Q165313, ENSP000003017644I2D: score=1 STRING: ENSP00000301764
    ZHX1Q9UKY13, ENSP000002978574I2D: score=1 STRING: ENSP00000297857
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    USF1P224153, ENSP000003569994I2D: score=1 STRING: ENSP00000356999
    NCOA2Q155963, ENSP000003999684I2D: score=1 STRING: ENSP00000399968
    BCRP112743, ENSP000003035074I2D: score=4 STRING: ENSP00000303507
    DDX17Q928411, ENSP000003800334EBI-366083,EBI-746012 STRING: ENSP00000380033
    SREBF2Q127721, ENSP000003544764EBI-366083,EBI-465059 STRING: ENSP00000354476
    FAM173AQ9BQD73I2D: score=4 
    LAMA4Q163633I2D: score=4 
    PRMT1Q998733I2D: score=4 
    WDR33Q9C0J83I2D: score=4 
    CDK1P064933I2D: score=3 
    GPS2Q132273I2D: score=3 
    SNRPNP631623I2D: score=3 
    NTHL1P785493I2D: score=2 
    ANK2Q014843I2D: score=1 
    ATG10Q9H0Y03I2D: score=1 
    BAG1Q999333I2D: score=1 
    CA11O754933I2D: score=1 
    CYP27B1O155283I2D: score=1 
    HINFPQ9BQA53I2D: score=1 
    HIRAP541983I2D: score=1 
    IFRD1O004583I2D: score=1 
    INPP5EQ9NRR63I2D: score=1 
    IRF9Q009783I2D: score=1 
    KCNJ5P485443I2D: score=1 
    KMT2AQ031643I2D: score=1 
    MRE11AP499593I2D: score=1 
    MUC1P159413I2D: score=1 
    NAE1Q135643I2D: score=1 
    PCDHA13Q9Y5I03I2D: score=1 
    PLA2G2AP145553I2D: score=1 
    PRR24C9JVW03I2D: score=1 
    PSMC3P179803I2D: score=1 
    PSMD4P550363I2D: score=1 
    RARAP102763I2D: score=1 
    RELAQ042063I2D: score=1 
    RNF34Q969K33I2D: score=1 
    RPL23P628293I2D: score=1 
    SMG1Q96Q153I2D: score=1 
    SQSTM1Q135013I2D: score=1 
    STAT1P422243I2D: score=1 
    TMSB4XP623283I2D: score=1 
    TP53TG1Q9Y2A03I2D: score=1 
    TRIAP1O437153I2D: score=1 
    UBA52P629873I2D: score=1 
    ZNF292O602813I2D: score=1 
    ATAD3AQ9NVI72MINT-8415512
    ATAD3BQ5T9A42MINT-8415512
    BAG2O958162MINT-8415355
    BAG6P463792MINT-8415355
    C10orf2Q96RR12MINT-8415512
    CCT2P783712MINT-8415355
    CCT3P493682MINT-8415355
    CCT4P509912MINT-8415355
    CCT6AP402272MINT-8415355
    CCT7Q998322MINT-8415355
    CCT8P509902MINT-8415355
    COLGALT1Q8NBJ52MINT-8415355
    CSNK2A2P197842MINT-8415512
    ENSG00000096155P463792MINT-8415355
    ENSG00000183311P074372MINT-8415355
    ENSG00000224156P074372MINT-8415355
    ENSG00000227739P074372MINT-8415355
    ENSG00000227761P463792MINT-8415355
    ENSG00000228760P463792MINT-8415355
    ENSG00000229524P463792MINT-8415355
    ENSG00000229684P074372MINT-8415355
    ENSG00000232421P074372MINT-8415355
    ENSG00000232575P074372MINT-8415355
    ENSG00000233348P463792MINT-8415355
    ENSG00000234651P463792MINT-8415355
    ENSG00000235067P074372MINT-8415355
    ENSG00000258947Q135092MINT-8415355
    FBXW8Q8N3Y12MINT-8415355
    GRB2P629932MINT-8415355
    HERC2O957142MINT-8415512
    KHDRBS1Q076662MINT-8415512
    MPP5Q8N3R92MINT-8415512
    MRPS22P826502MINT-8415512
    NEURL4Q96JN82MINT-8415512
    NT5C2P499022MINT-8415512
    NUDT16L1Q9BRJ72MINT-8415355
    OLA1Q9NTK52MINT-8415355
    PLOD3O605682MINT-8415355
    PPIFP304051EBI-366083,EBI-5544229
    PPM1GO153552MINT-8415355
    PSMC1P621912MINT-8415512
    PSMD2Q132002MINT-8415512
    PSMD5Q164012MINT-8415512
    PYCRLQ53H962MINT-8415355
    RABGAP1Q9Y3P92MINT-8415355
    RANBP9Q96S592MINT-8415512
    RBX1P628772MINT-8415355
    SARS2Q9NP812MINT-8415512
    SKP1P632082MINT-8415355
    SMARCAL1Q9NZC92MINT-8415512
    SMG5Q9UPR32MINT-8415355
    SMG7Q925402MINT-8415355
    TCP1P179872MINT-8415355
    TDRD12Q587J72MINT-8415355
    TOP3AQ134722MINT-8415512
    TRAF1Q130772MINT-8415355
    TSPAN10Q9H1Z92MINT-8415355
    TSPYL4Q9UJ042MINT-8415355
    TUBBP074372MINT-8415355
    TUBB2AQ138852MINT-8415355
    TUBB3Q135092MINT-8415355
    USP28Q96RU22MINT-8415355
    YTHDC2Q9H6S02MINT-8415512
    YWHAQP273482MINT-8415355
    AFPENSP000002263594STRING: ENSP00000226359
    AIFM2ENSP000003123704STRING: ENSP00000312370
    APAF1ENSP000003530594STRING: ENSP00000353059
    BCL2L14ENSP000003091324STRING: ENSP00000309132
    BCL2L2ENSP000002504054STRING: ENSP00000250405
    BCL6ENSP000002320144STRING: ENSP00000232014
    BDKRB2ENSP000003077134STRING: ENSP00000307713
    BDNFENSP000004143034STRING: ENSP00000414303
    BIDENSP000003188224STRING: ENSP00000318822
    BNIP3LENSP000003700034STRING: ENSP00000370003
    BTG2ENSP000002905514STRING: ENSP00000290551
    C12orf5ENSP000001792594STRING: ENSP00000179259
    CASP10ENSP000002861864STRING: ENSP00000286186
    CASP6ENSP000002651644STRING: ENSP00000265164
    CAV1ENSP000003391914STRING: ENSP00000339191
    CCNB1ENSP000002564424STRING: ENSP00000256442
    CCNKENSP000003745294STRING: ENSP00000374529
    CD82ENSP000002271554STRING: ENSP00000227155
    CHAF1AENSP000003012804STRING: ENSP00000301280
    COL18A1ENSP000003527984STRING: ENSP00000352798
    CSNK1EENSP000003529294STRING: ENSP00000352929
    CTSDENSP000002366714STRING: ENSP00000236671
    CX3CL1ENSP000000060534STRING: ENSP00000006053
    DDB2ENSP000002569964STRING: ENSP00000256996
    DDIT4ENSP000003073054STRING: ENSP00000307305
    DGCR8ENSP000002632094STRING: ENSP00000263209
    DKK1ENSP000003630814STRING: ENSP00000363081
    DROSHAENSP000003398454STRING: ENSP00000339845
    DUSP5ENSP000003585964STRING: ENSP00000358596
    DYRK2ENSP000003421054STRING: ENSP00000342105
    EDN2ENSP000003616684STRING: ENSP00000361668
    EGFRENSP000002754934STRING: ENSP00000275493
    EPHA2ENSP000003512094STRING: ENSP00000351209
    FDXRENSP000002931954STRING: ENSP00000293195
    FOSENSP000003062454STRING: ENSP00000306245
    GDF15ENSP000002528094STRING: ENSP00000252809
    GPX1ENSP000004073754STRING: ENSP00000407375
    HIC1ENSP000003140804STRING: ENSP00000314080
    IGFBP3ENSP000003704734STRING: ENSP00000370473
    IRF5ENSP000003497704STRING: ENSP00000349770
    JUNENSP000003602664STRING: ENSP00000360266
    LIFENSP000002490754STRING: ENSP00000249075
    MAP4K4ENSP000003136444STRING: ENSP00000313644
    MAXENSP000003514904STRING: ENSP00000351490
    MCL1ENSP000003580224STRING: ENSP00000358022
    METENSP000003172724STRING: ENSP00000317272
    MLH1ENSP000002317904STRING: ENSP00000231790
    MMP2ENSP000002190704STRING: ENSP00000219070
    MYBENSP000003399924STRING: ENSP00000339992
    NDRG1ENSP000003199774STRING: ENSP00000319977
    NFYCENSP000003966204STRING: ENSP00000396620
    NGFRENSP000001722294STRING: ENSP00000172229
    NOTCH1ENSP000002775414STRING: ENSP00000277541
    NOTCH2ENSP000002566464STRING: ENSP00000256646
    PCBP4ENSP000003784614STRING: ENSP00000378461
    PIDDENSP000003377974STRING: ENSP00000337797
    PMAIP1ENSP000003261194STRING: ENSP00000326119
    About this table

    Gene Ontology (GO): 5/96 biological process terms (GO ID links to tree view) (see all 96):    About this table

    GO IDQualified GO termEvidencePubMed IDs