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Aliases for TP53 Gene

Aliases for TP53 Gene

  • Tumor Protein P53 2 3
  • P53 3 4 6
  • Phosphoprotein P53 3 4
  • Antigen NY-CO-13 3 4
  • BCC7 3 6
  • LFS1 3 6
  • Transformation-Related Protein 53 3
  • Cellular Tumor Antigen P53 3
  • Mutant Tumor Protein 53 3
  • Li-Fraumeni Syndrome 2
  • P53 Tumor Suppressor 3
  • Tumor Suppressor P53 4
  • Tumor Protein 53 3
  • TRP53 3

External Ids for TP53 Gene

Previous GeneCards Identifiers for TP53 Gene

  • GC17P008026
  • GC17M008311
  • GC17M007514
  • GC17M007772
  • GC17M007512
  • GC17M007565
  • GC17M007465

Summaries for TP53 Gene

Entrez Gene Summary for TP53 Gene

  • This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]

GeneCards Summary for TP53 Gene

TP53 (Tumor Protein P53) is a Protein Coding gene. Diseases associated with TP53 include adrenocortical carcinoma and nasopharyngeal carcinoma. Among its related pathways are PI3K-Akt signaling pathway and MAPK signaling pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is TP73.

UniProtKB/Swiss-Prot for TP53 Gene

  • Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).

Tocris Summary for TP53 Gene

  • p53 (aka TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (such as DNA damage, hypoxia, spindle damage). Activation of p53 begins through a number of mechanisms including phosphorylation by ATM, ATR, Chk1 and MAPKs. MDM2 is a ubiquitn ligase that binds p53 and targets p53 for proteasomal degradation. Phosphorylation, p14ARF and USP7 prevent MDM2-p53 interactions, leading to an increase in stable p53 tetramers in the cytoplasm. Further modifications such as methylation and acetylation lead to an increase in p53 binding to gene specific response elements. p53 regulates a large number of genes (>100 genes) that control a number of key tumor suppressing functions such as cell cycle arrest, DNA repair, senescence and apoptosis. Whilst the activation of p53 often leads to apoptosis, p53 inactivation facilitates tumor progression; inactivating p53 mutations occur in over 50% of cancers.

Gene Wiki entry for TP53 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP53 Gene

Genomics for TP53 Gene

Regulatory Elements for TP53 Gene

Genomic Location for TP53 Gene

Start:
7,661,779 bp from pter
End:
7,687,550 bp from pter
Size:
25,772 bases
Orientation:
Minus strand

Genomic View for TP53 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TP53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53 Gene

Proteins for TP53 Gene

  • Protein details for TP53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04637-P53_HUMAN
    Recommended name:
    Cellular tumor antigen p53
    Protein Accession:
    P04637
    Secondary Accessions:
    • Q15086
    • Q15087
    • Q15088
    • Q16535
    • Q16807
    • Q16808
    • Q16809
    • Q16810
    • Q16811
    • Q16848
    • Q2XN98
    • Q3LRW1
    • Q3LRW2
    • Q3LRW3
    • Q3LRW4
    • Q3LRW5
    • Q86UG1
    • Q8J016
    • Q99659
    • Q9BTM4
    • Q9HAQ8
    • Q9NP68
    • Q9NPJ2
    • Q9NZD0
    • Q9UBI2
    • Q9UQ61

    Protein attributes for TP53 Gene

    Size:
    393 amino acids
    Molecular mass:
    43653 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1 (By similarity). Binds DNA as a homotetramer. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. In vitro, the interaction of TP53 with cancer-associated/HPV (E6) viral proteins leads to ubiquitination and degradation of TP53 giving a possible model for cell growth regulation. This complex formation requires an additional factor, E6-AP, which stably associates with TP53 in the presence of E6. Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1. Interacts with WWOX. May interact with HCV core protein. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity (By similarity). Interacts with ARMC10, BANP, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F1. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on Ser-58 inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation. Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-382) with L3MBTL1. Isoform 1 interacts with isoform 2 and with isoform 4. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with AURKB, SETD2, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2. Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by cyclosporin A (CsA). Interacts with human cytomegalovirus/HHV-5 protein UL123. Interacts with SNAI1; the interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion. Interacts with KAT6A. Interacts with UBC9. Interacts with ZNF385B; the interaction is direct. Interacts (via DNA-binding domain) with ZNF385A; the interaction is direct and enhances p53/TP53 transactivation functions on cell-cycle arrest target genes, resulting in growth arrest. Interacts with ANKRD2. Interacts with RFFL and RNF34; involved in p53/TP53 ubiquitination. Interacts with MTA1 and RFWD2.

    Three dimensional structures from OCA and Proteopedia for TP53 Gene

    Alternative splice isoforms for TP53 Gene

neXtProt entry for TP53 Gene

Proteomics data for TP53 Gene at MOPED

Post-translational modifications for TP53 Gene

  • Acetylated. Acetylation of Lys-382 by CREBBP enhances transcriptional activity. Deacetylation of Lys-382 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylation by SIRT2 impairs its ability to induce transcription activation in a AKT-dependent manner.
  • Dephosphorylated by PP2A-PPP2R5C holoenzyme at Thr-55. SV40 small T antigen inhibits the dephosphorylation by the AC form of PP2A
  • May be O-glycosylated in the C-terminal basic region. Studied in EB-1 cell line.
  • Monomethylated at Lys-372 by SETD7, leading to stabilization and increased transcriptional activation. Monomethylated at Lys-370 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity. Lys-372 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-370. Dimethylated at Lys-373 by EHMT1 and EHMT2. Monomethylated at Lys-382 by SETD8, promoting interaction with L3MBTL1 and leading to repress transcriptional activity. Dimethylation at Lys-370 and Lys-382 diminishes p53 ubiquitination, through stabilizing association with the methyl reader PHF20. Demethylation of dimethylated Lys-370 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation
  • Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylated by HIPK1 (By similarity). Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter. Phosphorylated on Thr-18 by VRK1. Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2. Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis. Phosphorylated on Thr-55 by TAF1, which promotes MDM2-mediated degradation. Phosphorylated on Ser-33 by CDK7 in a CAK complex in response to DNA damage. Phosphorylated on Ser-46 by HIPK2 upon UV irradiation. Phosphorylation on Ser-46 is required for acetylation by CREBBP. Phosphorylated on Ser-392 following UV but not gamma irradiation. Phosphorylated on Ser-15 upon ultraviolet irradiation; which is enhanced by interaction with BANP. Phosphorylated by NUAK1 at Ser-15 and Ser-392; was intially thought to be mediated by STK11/LKB1 but it was later shown that it is indirect and that STK11/LKB1-dependent phosphorylation is probably mediated by downstream NUAK1 (PubMed:21317932). It is unclear whether AMP directly mediates phosphorylation at Ser-15. Phosphorylated on Thr-18 by isoform 1 and isoform 2 of VRK2. Phosphorylation on Thr-18 by isoform 2 of VRK2 results in a reduction in ubiquitination by MDM2 and an increase in acetylation by EP300. Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated by DYRK2 at Ser-46 in response to genotoxic stress. Phosphorylated at Ser-315 and Ser-392 by CDK2 in response to DNA-damage.
  • Sumoylated with SUMO1. Sumoylated at Lys-386 by UBC9.
  • Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. Ubiquitinated by MKRN1 at Lys-291 and Lys-292, which leads to proteasomal degradation. Deubiquitinated by USP10, leading to its stabilization. Ubiquitinated by TRIM24, RFFL and RNF34, which leads to proteasomal degradation. Ubiquitination by TOPORS induces degradation. Deubiquitination by USP7, leading to stabilization. Isoform 4 is monoubiquitinated in an MDM2-independent manner. Ubiquitinated by RFWD2, which leads to proteasomal degradation.
  • Ubiquitination at Lys101, Lys132, Lys164, Lys291, Lys292, Lys305, Lys320, and Lys321
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TP53 Gene

Domains for TP53 Gene

Graphical View of Domain Structure for InterPro Entry

P04637

UniProtKB/Swiss-Prot:

P53_HUMAN :
  • P04637
Domain:
  • The nuclear export signal acts as a transcriptional repression domain. The TADI and TADII motifs (residues 17 to 25 and 48 to 56) correspond both to 9aaTAD motifs which are transactivation domains present in a large number of yeast and animal transcription factors.
Family:
  • Belongs to the p53 family.
genes like me logo Genes that share domains with TP53: view

No data available for Gene Families for TP53 Gene

Function for TP53 Gene

Molecular function for TP53 Gene

GENATLAS Biochemistry: tumor suppressor protein p53 required for G1 growth arrest by WAF1 (CDKN1A),following DNA damage or induction of apoptosis,also regulating a G2 checkpoint through cyclin B1,transcriptional activator through acetylation of transactivation site by CREBBP binding MDM2 resulting in transcriptional silencing and ubiquitin/proteasome dependent degradation of p53,activated by conjugation to UBL1 (SUMO1),putative up-regulated c-MYC target gene,putative teratologic suppressor gene and modulator of TFIIH (GTF2H),associated in nucleotide excision repair,activated by ATM in association with 14.3.3 proteins (YWHA*),tumor suppressor gene (see TSG17A),mutated in cancers such as pancreas and endometrial carcinomas,in Barretts adenocarcinoma (and esophageal squamous cell carcinoma),in hepatocellular carcinoma with poor prognosis
UniProtKB/Swiss-Prot Function: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).
UniProtKB/Swiss-Prot Induction: Up-regulated in response to DNA damage. Isoform 2 is not induced in tumor cells in response to stress.

Gene Ontology (GO) - Molecular Function for TP53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IDA 24652652
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0001085 RNA polymerase II transcription factor binding IPI 18549481
genes like me logo Genes that share ontologies with TP53: view
genes like me logo Genes that share phenotypes with TP53: view

Animal Models for TP53 Gene

MGI Knock Outs for TP53:

Transcription Factor Targeting for TP53 Gene

Selected GeneGlobe predicted Target genes for TP53
Targeting motifs for TP53 Gene
HOMER Transcription Factor Regulatory Elements motif TP53
  • Consensus sequence: AACATGCCCAGACATGCCCN Submotif: canonical Cell Type: Saos GeoId: GSE15780

No data available for Enzyme Numbers (IUBMB) for TP53 Gene

Localization for TP53 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP53 Gene

Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Translocates to mitochondria upon oxidative stress.
Isoform 1: Nucleus. Cytoplasm. Note=Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4.
Isoform 2: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in the cytoplasm.
Isoform 3: Nucleus. Cytoplasm. Note=Localized in the nucleus in most cells but found in the cytoplasm in some cells.
Isoform 4: Nucleus. Cytoplasm. Note=Predominantly nuclear but translocates to the cytoplasm following cell stress.
Isoform 7: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in the cytoplasm.
Isoform 8: Nucleus. Cytoplasm. Note=Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli.
Isoform 9: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TP53 Gene COMPARTMENTS Subcellular localization image for TP53 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
mitochondrion 5
nucleus 5
cytoskeleton 3
extracellular 3
lysosome 2
plasma membrane 2
vacuole 2
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TP53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA --
GO:0000790 nuclear chromatin IDA 15710329
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005657 replication fork IBA --
genes like me logo Genes that share ontologies with TP53: view

Pathways for TP53 Gene

genes like me logo Genes that share pathways with TP53: view

Interacting Proteins for TP53 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000269305%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000268058%0d%0a9606.ENSP00000321239%0d%0a9606.ENSP00000417281%0d%0a9606.ENSP00000278616%0d%0a
Selected Interacting proteins: P04637-P53_HUMAN ENSP00000269305 for TP53 Gene via MINT STRING UniProtKB I2D

Symbol External ID(s) Details
MDM2
UBC
PSME3
EP300
MKRN1

Gene Ontology (GO) - Biological Process for TP53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IEA --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS 19749791
GO:0000733 DNA strand renaturation IDA 8183576
GO:0001701 in utero embryonic development IEA --
GO:0001756 somitogenesis IEA --
genes like me logo Genes that share ontologies with TP53: view

Compounds for TP53 Gene

(15) ApexBio Compounds for TP53 Gene

Compound Action Cas Number
AMG232 potent and selective piperidinone inhibitor of the MDM2-p53 interaction.
CP 31398 dihydrochloride p53 stabilizing agent. [1217195-61-3]
JNJ-26854165 (Serdemetan) p53 activator, blocking Mdm2-p53 interaction [881202-45-5]
Nutlin-3 inhibitor of the MDM2/p53 interaction [890090-75-2]
Nutlin-3a chiral inhibits the MDM2-p53 interaction and activates p53. [675576-98-4]
p53 and MDM2 proteins-interaction-inhibitor chiral inhibitor of the interaction between p53 and MDM2 proteins. [939981-37-0]
Pifithrin-miu Inhibits p53 binding to mitochondria. [64984-31-2]
PRIMA-1 Cell-permeable BAX inhibitor, restore p53 activity [5608-24-2]
PRIMA-1MET Cell-permeable BAX inhibitor, restore p53 activity [5291-32-7]
RG7112 Restoration of p53 activity by inhibiting the p53-MDM2 interaction. [939981-39-2]
RG7388 Blocking the MDM2-p53 interaction stabilizes p53. [1229705-06-9]
RITA (NSC 652287) Cell-permeable antitumor agent, blocking Mdm2-p53 interaction and p53 ubiquitination [213261-59-7]
SJ 172550 Inhibits the MDMX-p53 interaction in cultured retinoblastoma cells. [431979-47-4]
Tenovin-1 Cell-permeable, reversible SIRT2 inhibitor, activates p53 [380315-80-0]
Tenovin-3 Tenovin-3 [1011301-27-1]

(5) Tocris Compounds for TP53 Gene

Compound Action Cas Number
Cyclic Pifithrin-alpha hydrobromide p53 inhibitor [511296-88-1]
HLI 373 Hdm2 inhibitor; activates p53-dependent transcription [502137-98-6]
Pifithrin-alpha hydrobromide p53 inhibitor. Also aryl hydrocarbon receptor agonist [63208-82-2]
Pifithrin-mu Inhibitor of p53-mitochondrial binding [64984-31-2]
PRIMA-1MET Restores mutant p53 activity [5291-32-7]

(1) Drugbank Compounds for TP53 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine
target

(117) Novoseek inferred chemical compound relationships for TP53 Gene

Compound -log(P) Hits PubMed IDs
paraffin 76.9 127
cisplatin 74 394
noxa 72.7 68
hpvs 71.4 53
estrogen 71 242

(5) PharmGKB related drug/compound annotations for TP53 Gene

Drug/compound Annotation
antineoplastic agents CA
cisplatin CA
cyclophosphamide CA
fluorouracil CA
paclitaxel CA
genes like me logo Genes that share compounds with TP53: view

Transcripts for TP53 Gene

Unigene Clusters for TP53 Gene

Tumor protein p53:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TP53 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
SP1: - - - -
SP2: -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - - -
SP7:
SP8: -
SP9: -

Relevant External Links for TP53 Gene

GeneLoc Exon Structure for
TP53
ECgene alternative splicing isoforms for
TP53

Expression for TP53 Gene

mRNA expression in normal human tissues for TP53 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TP53 Gene

SOURCE GeneReport for Unigene cluster for TP53 Gene Hs.437460

mRNA Expression by UniProt/SwissProt for TP53 Gene

P04637-P53_HUMAN
Tissue specificity: Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine.
genes like me logo Genes that share expressions with TP53: view

No data available for mRNA differential expression in normal tissues for TP53 Gene

Orthologs for TP53 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TP53 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TP53 35
  • 99.75 (n)
  • 100 (a)
TP53 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TP53 35
  • 83.9 (n)
  • 82.08 (a)
TP53 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia P53 36
  • 81 (a)
OneToOne
TP53 35
  • 84.3 (n)
  • 83.42 (a)
mouse
(Mus musculus)
Mammalia Trp53 35
  • 80.62 (n)
  • 78.55 (a)
Trp53 16
Trp53 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TP53 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TP53 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tp53 35
  • 80.5 (n)
  • 77.32 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.20943 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6676 35
tp53 35
  • 59.21 (n)
  • 57.22 (a)
zebrafish
(Danio rerio)
Actinopterygii tp53 35
  • 57.35 (n)
  • 59.21 (a)
tp53 36
  • 51 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
ManyToMany
CSA.2527 36
  • 24 (a)
ManyToMany
Species with no ortholog for TP53:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TP53 Gene

ENSEMBL:
Gene Tree for TP53 (if available)
TreeFam:
Gene Tree for TP53 (if available)

Paralogs for TP53 Gene

Paralogs for TP53 Gene

genes like me logo Genes that share paralogs with TP53: view

Variants for TP53 Gene

Sequence variations from dbSNP and Humsavar for TP53 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs722494 -- 7,680,073(+) ATGCA(C/G)GTGCC intron-variant
rs858528 -- 7,671,618(-) AGAGC(A/G)AGACT intron-variant
rs916131 -- 7,669,118(-) GTCTA(A/G)AACTT utr-variant-3-prime
rs916132 -- 7,669,095(-) GGTGC(C/T)TGTTC utr-variant-3-prime
rs1042522 Uncertain significance, - 7,676,154(-) TCCCC(C/G)CGTGG reference, missense, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TP53 Gene

Variant ID Type Subtype PubMed ID
nsv457659 CNV Loss 19166990

Relevant External Links for TP53 Gene

HapMap Linkage Disequilibrium report
TP53
Human Gene Mutation Database (HGMD)
TP53
Locus Specific Mutation Databases (LSDB)
TP53

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TP53 Gene

Disorders for TP53 Gene

(11) OMIM Diseases for TP53 Gene (191170)

UniProtKB/Swiss-Prot

P53_HUMAN
  • Note=TP53 is found in increased amounts in a wide variety of transformed cells. TP53 is frequently mutated or inactivated in about 60% of cancers. TP53 defects are found in Barrett metaplasia a condition in which the normally stratified squamous epithelium of the lower esophagus is replaced by a metaplastic columnar epithelium. The condition develops as a complication in approximately 10% of patients with chronic gastroesophageal reflux disease and predisposes to the development of esophageal adenocarcinoma.
  • Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Li-Fraumeni syndrome (LFS) [MIM:151623]: Autosomal dominant familial cancer syndrome that in its classic form is defined by the existence of a proband affected by a sarcoma before 45 years with a first degree relative affected by any tumor before 45 years and another first degree relative with any tumor before 45 years or a sarcoma at any age. Other clinical definitions for LFS have been proposed (PubMed:8118819 and PubMed:8718514) and called Li-Fraumeni like syndrome (LFL). In these families affected relatives develop a diverse set of malignancies at unusually early ages. Four types of cancers account for 80% of tumors occurring in TP53 germline mutation carriers: breast cancers, soft tissue and bone sarcomas, brain tumors (astrocytomas) and adrenocortical carcinomas. Less frequent tumors include choroid plexus carcinoma or papilloma before the age of 15, rhabdomyosarcoma before the age of 5, leukemia, Wilms tumor, malignant phyllodes tumor, colorectal and gastric cancers. {ECO:0000269 PubMed:10484981, ECO:0000269 PubMed:1565144, ECO:0000269 PubMed:1737852, ECO:0000269 PubMed:1933902, ECO:0000269 PubMed:1978757, ECO:0000269 PubMed:2259385, ECO:0000269 PubMed:7887414, ECO:0000269 PubMed:8825920, ECO:0000269 PubMed:9452042}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. Note=The gene represented in this entry is involved in disease pathogenesis.
  • Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Papilloma of choroid plexus (CPP) [MIM:260500]: A benign tumor of neuroectodermal origin that generally occurs in childhood, but has also been reported in adults. Although generally found within the ventricular system, choroid plexus papillomas can arise ectopically in the brain parenchyma or disseminate throughout the neuraxis. Patients present with signs and symptoms of increased intracranial pressure including headache, hydrocephalus, papilledema, nausea, vomiting, cranial nerve deficits, gait impairment, and seizures. {ECO:0000269 PubMed:12085209}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Adrenocortical carcinoma (ADCC) [MIM:202300]: A malignant neoplasm of the adrenal cortex and a rare childhood tumor. It occurs with increased frequency in patients with Beckwith-Wiedemann syndrome and Li-Fraumeni syndrome. {ECO:0000269 PubMed:11481490}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Basal cell carcinoma 7 (BCC7) [MIM:614740]: A common malignant skin neoplasm that typically appears on hair-bearing skin, most commonly on sun-exposed areas. It is slow growing and rarely metastasizes, but has potentialities for local invasion and destruction. It usually develops as a flat, firm, pale area that is small, raised, pink or red, translucent, shiny, and waxy, and the area may bleed following minor injury. Tumor size can vary from a few millimeters to several centimeters in diameter. {ECO:0000269 PubMed:21946351}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(96) Novoseek inferred disease relationships for TP53 Gene

Disease -log(P) Hits PubMed IDs
tumors 93.8 649
li-fraumeni syndrome 90.7 146
cancer 90.2 474
carcinoma 87.5 463
carcinoma squamous cell 86.8 339

Relevant External Links for TP53

GeneTests
TP53
GeneReviews
TP53
Genetic Association Database (GAD)
TP53
Human Genome Epidemiology (HuGE) Navigator
TP53
Tumor Gene Database (TGDB):
TP53
genes like me logo Genes that share disorders with TP53: view

Publications for TP53 Gene

  1. Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens. (PMID: 1327751) Crook T. … Vousden K.H. (EMBO J. 1992) 3 4 23
  2. Frequent p53 mutations in head and neck cancer. (PMID: 1394225) Somers K.D. … Casey G. (Cancer Res. 1992) 3 4 23
  3. Clonal p53 mutation in primary cervical cancer: association with human-papillomavirus-negative tumours. (PMID: 1349102) Crook T. … Vousden K.H. (Lancet 1992) 3 23 48
  4. Mutations of the P53 gene, including an intronic point mutation, in colorectal tumors. (PMID: 1647768) Ishioka C. … Yamazaki T. (Biochem. Biophys. Res. Commun. 1991) 3 4 23
  5. p53 mutations in colorectal cancer. (PMID: 1699228) Rodrigues N.R. … Lane D.P. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 4 23

Products for TP53 Gene

  • Addgene plasmids for TP53

Sources for TP53 Gene

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