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TP53 Gene

protein-coding   GIFtS: 80
GCID: GC17M007565

Tumor Protein P53

  See TP53-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Protein P531 2     TRP532
P532 3 5     Cellular Tumor Antigen P532
Antigen NY-CO-132 3     Mutant Tumor Protein 532
Phosphoprotein P532 3     P53 Tumor Suppressor2
BCC72 5     Transformation-Related Protein 532
LFS12 5     Tumor Protein 532
Li-Fraumeni Syndrome1     Tumor Suppressor P533

External Ids:    HGNC: 119981   Entrez Gene: 71572   Ensembl: ENSG000001415107   OMIM: 1911705   UniProtKB: P046373   

Export aliases for TP53 gene to outside databases

Previous GC identifers: GC17P008026 GC17M008311 GC17M007514 GC17M007772 GC17M007512 GC17M007465


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TP53 Gene:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and
oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of
target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism.
Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as
Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple
transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate
translation initiation codons (PMIDs: 12032546, 20937277). (provided by RefSeq, Feb 2013)

GeneCards Summary for TP53 Gene:
TP53 (tumor protein p53) is a protein-coding gene. Diseases associated with TP53 include hepatocellular carcinoma, and osteosarcoma. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TP73.

UniProtKB/Swiss-Prot: P53_HUMAN, P04637
Function: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the
physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to
negatively regulate cell division by controlling a set of genes required for this process. One of the activated
genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation
of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF
is involved in activating oxidative stress-induced necrosis; the function is largely independent of
transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1.
LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to
effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when
associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the
transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses
transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform
1-mediated apoptosis

summary for TP53 Gene:
p53 (aka TP53) is a transcription factor whose protein levels and post-translational modification state
alter in response to cellular stress (such as DNA damage, hypoxia, spindle damage). Activation of p53 begins
through a number of mechanisms including phosphorylation by ATM, ATR, Chk1 and MAPKs. MDM2 is a ubiquitn
ligase that binds p53 and targets p53 for proteasomal degradation. Phosphorylation, p14ARF and USP7 prevent
MDM2-p53 interactions, leading to an increase in stable p53 tetramers in the cytoplasm. Further
modifications such as methylation and acetylation lead to an increase in p53 binding to gene specific
response elements. p53 regulates a large number of genes (>100 genes) that control a number of key tumor
suppressing functions such as cell cycle arrest, DNA repair, senescence and apoptosis. Whilst the activation
of p53 often leads to apoptosis, p53 inactivation facilitates tumor progression; inactivating p53 mutations
occur in over 50% of cancers.

Gene Wiki entry for TP53 (P53) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TP53 gene promoter:
         CREB   C/EBPbeta   Sp1   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): TP53 promoter sequence
   Search Chromatin IP Primers for TP53

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TP53


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

TP53 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP53 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007565:  view genomic region     (about GC identifiers)

Start:
7,565,097 bp from pter      End:
7,590,863 bp from pter
Size:
25,767 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TP53

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: P53_HUMAN, P04637 (See protein sequence)
Recommended Name: Cellular tumor antigen p53  
Size: 393 amino acids; 43653 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1 (By similarity).
Binds DNA as a homotetramer. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and
CARM1, and recruits them to promoters. In vitro, the interaction of TP53 with cancer-associated/HPV (E6) viral
proteins leads to ubiquitination and degradation of TP53 giving a possible model for cell growth regulation. This
complex formation requires an additional factor, E6-AP, which stably associates with TP53 in the presence of E6.
Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this
interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1.
Interacts with WWOX. May interact with HCV core protein. Interacts with USP7 and SYVN1. Interacts with HSP90AB1.
Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity (By similarity).
Interacts with ARMC10, BANP, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F1. Interacts with YWHAZ; the interaction
enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts
(via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus).
Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with
FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the
phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation.
Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-382)
with L3MBTL1. Isoform 1 interacts with isoform 2 and with isoform 4. Interacts with GRK5. Binds to the CAK
complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with
AURKB, SETD2, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2.
Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the
association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by
cyclosporin A (CsA). Interacts with human cytomegalovirus/HHV-5 protein UL123. Interacts with SNAI1; the
interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion.
Interacts with KAT6A. Interacts with UBC9. Interacts with ZNF385B; the interaction is direct. Interacts (via
DNA-binding domain) with ZNF385A; the interaction is direct and enhances p53/TP53 transactivation functions on
cell-cycle arrest target genes, resulting in growth arrest. Interacts with ANKRD2. Interacts with RFFL (via
RING-type zinc finger); involved in p53/TP53 ubiquitination
Selected PDB 3D structures from and Proteopedia for TP53 (see all 119):
1A1U (3D)        1AIE (3D)        1C26 (3D)        1DT7 (3D)        1GZH (3D)        1H26 (3D)    
Secondary accessions: Q15086 Q15087 Q15088 Q16535 Q16807 Q16808 Q16809 Q16810 Q16811 Q16848
Q2XN98 Q3LRW1 Q3LRW2 Q3LRW3 Q3LRW4 Q3LRW5 Q86UG1 Q8J016 Q99659 Q9BTM4 Q9HAQ8 Q9NP68 Q9NPJ2
Q9NZD0 Q9UBI2 Q9UQ61
Alternative promoter usage, Alternative splicing: 9 isoforms:  P04637-1   P04637-2   P04637-3   P04637-4   P04637-5   P04637-6   P04637-7   P04637-8   
P04637-9   (Produced by alternative promoter usage and alternative splicing)

Explore the universe of human proteins at neXtProt for TP53: NX_P04637

Explore proteomics data for TP53 at MOPED

Post-translational modifications: 

  • Acetylated. Acetylation of Lys-382 by CREBBP enhances transcriptional activity. Deacetylation of Lys-382 by SIRT1
    impairs its ability to induce proapoptotic program and modulate cell senescence1
  • Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylated by HIPK1 (By similarity).
    Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter. Phosphorylated on Thr-18 by
    VRK1. Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2.
    Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated
    apoptosis. Phosphorylated on Thr-55 by TAF1, which promotes MDM2-mediated degradation. Phosphorylated on Ser-33
    by CDK7 in a CAK complex in response to DNA damage. Phosphorylated on Ser-46 by HIPK2 upon UV irradiation.
    Phosphorylation on Ser-46 is required for acetylation by CREBBP. Phosphorylated on Ser-392 following UV but not
    gamma irradiation. Phosphorylated on Ser-15 upon ultraviolet irradiation; which is enhanced by interaction with
    BANP. Phosphorylated by NUAK1 at Ser-15 and Ser-392; was intially thought to be mediated by STK11/LKB1 but it was
    later shown that it is indirect and that STK11/LKB1-dependent phosphorylation is probably mediated by downstream
    NUAK1 (PubMed:21317932). It is unclear whether AMP directly mediates phosphorylation at Ser-15. Phosphorylated on
    Thr-18 by isoform 1 and isoform 2 of VRK2. Phosphorylation on Thr-18 by isoform 2 of VRK2 results in a reduction
    in ubiquitination by MDM2 and an increase in acetylation by EP300. Stabilized by CDK5-mediated phosphorylation in
    response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53,
    particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated by DYRK2
    at Ser-46 in response to genotoxic stress. Phosphorylated at Ser-315 and Ser-392 by CDK2 in response to
    DNA-damage1
  • Dephosphorylated by PP2A-PPP2R5C holoenzyme at Thr-55. SV40 small T antigen inhibits the dephosphorylation by the
    AC form of PP2A1
  • May be O-glycosylated in the C-terminal basic region. Studied in EB-1 cell line1
  • Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in
    cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not
    targeted to the proteasome. Ubiquitinated by MKRN1 at Lys-291 and Lys-292, which leads to proteasomal
    degradation. Deubiquitinated by USP10, leading to its stabilization. Ubiquitinated by TRIM24 and RFFL, which
    leads to proteasomal degradation. Ubiquitination by TOPORS induces degradation. Deubiquitination by USP7, leading
    to stabilization. Isoform 4 is monoubiquitinated in an MDM2-independent manner1
  • Monomethylated at Lys-372 by SETD7, leading to stabilization and increased transcriptional activation.
    Monomethylated at Lys-370 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional
    regulation activity. Lys-372 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at
    Lys-370. Dimethylated at Lys-373 by EHMT1 and EHMT2. Monomethylated at Lys-382 by SETD8, promoting interaction
    with L3MBTL1 and leading to repress transcriptional activity. Dimethylation at Lys-370 and Lys-382 diminishes p53
    ubiquitination, through stabilizing association with the methyl reader PHF20. Demethylation of dimethylated
    Lys-370 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation1
  • Sumoylated with SUMO1. Sumoylated at Lys-386 by UBC91
  • Ubiquitination2 at Lys101, Lys132, Lys164, Lys291, Lys292, Lys305, Lys320, Lys321
  • Modification sites at PhosphoSitePlus

  • See TP53 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (15 alternative transcripts): 
    NP_000537.3  NP_001119584.1  NP_001119585.1  NP_001119586.1  NP_001119587.1  NP_001119588.1  NP_001119589.1  NP_001119590.1  
    NP_001263624.1  NP_001263625.1  NP_001263626.1  NP_001263627.1  NP_001263628.1  NP_001263689.1  NP_001263690.1  

    ENSEMBL proteins: 
     ENSP00000410739   ENSP00000352610   ENSP00000269305   ENSP00000398846   ENSP00000391127  
     ENSP00000391478   ENSP00000458393   ENSP00000425104   ENSP00000423862   ENSP00000424104  
     ENSP00000473895   ENSP00000426252  
    Reactome Protein details: P04637

    TP53 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant TP53 Protein
    R&D Systems Recombinant & Natural Proteins for TP53 (p53)
    Enzo Life Sciences proteins for TP53
    OriGene Purified Proteins for TP53
    OriGene Protein Over-expression Lysate for TP53
    OriGene MassSpec for TP53
    OriGene Custom Protein Services for TP53
    GenScript Custom Purified and Recombinant Proteins Services for TP53
    Novus Biologicals TP53 Proteins
    Novus Biologicals TP53 Lysates
    Sino Biological Recombinant Protein for TP53
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TP53
    Cloud-Clone Corp. Proteins for TP53

     
    Search eBioscience for Proteins for TP53 

    TP53 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TP53
    R&D Systems Antibodies for TP53 (p53)
    Cell Signaling Technology (CST) Antibodies for TP53  (p53)
    OriGene Antibodies for TP53
    OriGene Custom Antibody Services for TP53
    Novus Biologicals TP53 Antibodies
    Abcam antibodies for TP53
    Cloud-Clone Corp. Antibodies for TP53
    ThermoFisher Antibody for TP53
    LSBio Antibodies in human, mouse, rat for TP53

    TP53 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of TP53
    OriGene Custom Assay Services for TP53
    R&D Systems ELISAs for TP53 (p53)         (see all)
    GenScript Custom Assay Services for TP53
    Cell Signaling Technology (CST) Sandwich ELISA Kits for TP53 (p53)
    Enzo Life Sciences assays for TP53
    Cloud-Clone Corp. ELISAs for TP53
    Cloud-Clone Corp. CLIAs for TP53
    eBioscience ELISAs for TP53: (see all 4
                        p53 (Total/Phospho) InstantOne ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR011615 p53_DNA-bd
     IPR012346 p53/RUNT-type_TF_DNA-bd
     IPR002117 p53_tumour_suppressor
     IPR008967 p53-like_TF_DNA-bd
     IPR013872 p53_transactivation_domain

    Graphical View of Domain Structure for InterPro Entry P04637

    ProtoNet protein and cluster: P04637

    1 Blocks protein domain: IPB010991 p53

    UniProtKB/Swiss-Prot: P53_HUMAN, P04637
    Domain: The nuclear export signal acts as a transcriptional repression domain. The TADI and TADII motifs (residues
    17 to 25 and 48 to 56) correspond both to 9aaTAD motifs which are transactivation domains present in a large
    number of yeast and animal transcription factors
    Similarity: Belongs to the p53 family


    Find genes that share domains with TP53           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P53_HUMAN, P04637
    Function: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the
    physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to
    negatively regulate cell division by controlling a set of genes required for this process. One of the activated
    genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation
    of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF
    is involved in activating oxidative stress-induced necrosis; the function is largely independent of
    transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1.
    LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to
    effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when
    associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the
    transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses
    transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform
    1-mediated apoptosis
    Induction: Up-regulated in response to DNA damage. Isoform 2 is not induced in tumor cells in response to stress

         Genatlas biochemistry entry for TP53:
    tumor suppressor protein p53 required for G1 growth arrest by WAF1 (CDKN1A),following DNA damage or induction of
    apoptosis,also regulating a G2 checkpoint through cyclin B1,transcriptional activator through acetylation of
    transactivation site by CREBBP binding MDM2 resulting in transcriptional silencing and ubiquitin/proteasome
    dependent degradation of p53,activated by conjugation to UBL1 (SUMO1),putative up-regulated c-MYC target
    gene,putative teratologic suppressor gene and modulator of TFIIH (GTF2H),associated in nucleotide excision
    repair,activated by ATM in association with 14.3.3 proteins (YWHA*),tumor suppressor gene (see TSG17A),mutated in
    cancers such as pancreas and endometrial carcinomas,in Barrett's adenocarcinoma (and esophageal squamous cell
    carcinoma),in hepatocellular carcinoma with poor prognosis

         Gene Ontology (GO): Selected molecular function terms (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IEA--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0001085RNA polymerase II transcription factor binding IPI18549481
    GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA17146433
    GO:0002020protease binding IPI11923872
         
    Find genes that share ontologies with TP53           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for TP53:
     Decreased viability of wild-ty  Enable proliferation in B-Raf   Increased cell death HMECs cel  Increased resistance to MDM2 i 

         Selected MGI mutant phenotypes (inferred from 73 alleles(MGI details for Trp53) (see all 27):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    Find genes that share phenotypes with TP53           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TP53: Trp53tm1Mlh Trp53tm3Wahl Trp53tm5Wahl Trp53tm2Wahl Trp53tm1.1Manf Trp53tm1Tyj
                                                         Trp53tm1Mok Trp53tm1Sia Trp53tm1.1Brn Trp53tm1Brd

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TP53
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TP53

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TP53
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TP53

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for TP53 (see all 1892):
    AATF,  ABCC3,  ABCC6P2,  ABCD1,  ABCF1,  ABHD12,  ABHD15,  ABHD4,  ABHD8,  ABTB2

    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  AACATGCCCAGACATGCCCN 

    miRNA
    Products:
        
    miRTarBase miRNAs that target TP53:
    hsa-mir-1285-3p (MIRT005474), hsa-mir-125a-5p (MIRT004071), hsa-mir-221-3p (MIRT005785), hsa-mir-10b-5p (MIRT006923), hsa-mir-608 (MIRT016154), hsa-mir-324-5p (MIRT043041), hsa-mir-30d-5p (MIRT005418), hsa-mir-454-3p (MIRT039245), hsa-mir-16-5p (MIRT005764), hsa-mir-25-3p (MIRT005417), hsa-mir-15a-5p (MIRT005763), hsa-mir-605-5p (MIRT016155), hsa-mir-27a-3p (MIRT028744), hsa-mir-214-3p (MIRT006881), hsa-mir-34a-5p (MIRT007112), hsa-mir-150-5p (MIRT052652), hsa-mir-485-5p (MIRT016616), hsa-mir-222-3p (MIRT005786), hsa-mir-612 (MIRT005476), hsa-mir-504-5p (MIRT016257), hsa-mir-125b-5p (MIRT000535)

    Block miRNA regulation of human, mouse, rat TP53 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TP53 (see all 17):
    hsa-miR-576-3p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-98 hsa-miR-22
    SwitchGear 3'UTR luciferase reporter plasmidTP53 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TP53
    Predesigned siRNA for gene silencing in human, mouse, rat TP53

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TP53

    Clone
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    OriGene clones in human, mouse for TP53 (see all 37)
    OriGene ORF clones in mouse, rat for TP53
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): TP53 (NM_000546)
    Sino Biological Human cDNA Clone for TP53
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TP53
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53
    Addgene plasmids for TP53 

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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-11152 VA6-13337) for TP53 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    P53_HUMAN, P04637: Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix.
    Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2.
    Translocates to mitochondria upon oxidative stress
    P53_HUMAN, P04637: Isoform 1: Nucleus. Cytoplasm. Note=Predominantly nuclear but localizes to the cytoplasm
    when expressed with isoform 4
    P53_HUMAN, P04637: Isoform 2: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in
    the cytoplasm
    P53_HUMAN, P04637: Isoform 3: Nucleus. Cytoplasm. Note=Localized in the nucleus in most cells but found in the
    cytoplasm in some cells
    P53_HUMAN, P04637: Isoform 4: Nucleus. Cytoplasm. Note=Predominantly nuclear but translocates to the cytoplasm
    following cell stress
    P53_HUMAN, P04637: Isoform 7: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in
    the cytoplasm
    P53_HUMAN, P04637: Isoform 8: Nucleus. Cytoplasm. Note=Localized in both nucleus and cytoplasm in most cells.
    In some cells, forms foci in the nucleus that are different from nucleoli
    P53_HUMAN, P04637: Isoform 9: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endoplasmic reticulum5
    mitochondrion5
    nucleus5
    cytoskeleton3
    extracellular3
    lysosome2
    plasma membrane2
    vacuole2
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IBA--
    GO:0000790nuclear chromatin IDA15710329
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005657replication fork IBA--

    Find genes that share ontologies with TP53           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

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    SuperPaths for TP53 About   (see all 115)  
    See pathways by source

    SuperPathContained pathways About
    1Amyotrophic lateral sclerosis (ALS)
    Amyotrophic lateral sclerosis (ALS)0.63
    Pathogenesis of ALS0.31
    Amyotrophic lateral sclerosis (ALS)0.63
    2Glioma
    Glioma0.51
    Prostate cancer0.39
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    Melanoma0.43
    Bladder cancer0.31
    3Endometrial cancer
    Endometrial cancer0.45
    Colorectal cancer0.42
    Signal transduction PTEN pathway0.45
    4Development HGF signaling pathway
    Development Neurotrophin family signaling0.45
    Neurotrophin signaling pathway0.36
    Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    5Pyrimidine metabolism
    Fluoropyrimidine Activity0.69
    Fluoropyrimidine Pathway, Pharmacodynamics0.00


    Find genes that share SuperPaths with TP53           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for TP53
        Apoptosis Signaling Pathways
    Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TP53 (see all 41)
        Telomerase Components in Cell Signaling
    UVB-Induced MAPK Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer
    TRKA Signaling

    2 Cell Signaling Technology (CST) Pathways for TP53
        Cell Cycle / Checkpoint Control
    DNA Damage

    4 Tocris Bioscience Pathways for TP53
        Akt Pathway
    Apoptosis Pathway
    MAPK Pathway
    mTOR Pathway

    Selected GeneGo (Thomson Reuters) Pathways for TP53 (see all 13)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Immune response MIF in innate immunity response
    Transcription P53 signaling pathway
    Development Neurotrophin family signaling
    Signal transduction AKT signaling

    Selected BioSystems Pathways for TP53 (see all 38)
        MAPK signaling pathway
    Apoptosis
    Cell cycle
    Fluoropyrimidine Activity
    DNA damage response

    3 Sino Biological Pathways for TP53
        EGFR Signaling Pathway
    p53 Pathway
    Death Receptor Signaling

    Selected Reactome Pathways for TP53 (see all 11)
        Stabilization of p53
    Transcriptional activation of cell cycle inhibitor p21
    Oncogene Induced Senescence
    Activation of NOXA and translocation to mitochondria
    Activation of PUMA and translocation to mitochondria

    2 PharmGKB Pathways for TP53
        Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
    Fluoropyrimidine Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for TP53) (see all 33):
        MAPK signaling pathway
    Cell cycle
    p53 signaling pathway
    PI3K-Akt signaling pathway
    Apoptosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TP53 (see all 37): 
              Lung Cancer in human mouse rat
              Lymphoma in human mouse rat
              Prostate Cancer in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TP53

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TP53 (P046371, 2, 3 ENSP000002693054) via UniProtKB, MINT, STRING, and/or I2D (see all 951)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009871, 2, 3, ENSP000004172814EBI-366083,EBI-389668 MINT-6540920 MINT-4793511 MINT-6823775 MINT-7013943 MINT-8303857 MINT-6540905 MINT-68742 MINT-8385459 MINT-56681 MINT-8374464 MINT-58468 MINT-7013791 MINT-68743 MINT-7013956 MINT-4545014 MINT-8339574 MINT-4049631 MINT-6540776 MINT-6801380 MINT-8374452 MINT-58465 MINT-7013688 MINT-7013802 MINT-4303990 MINT-8339590 MINT-6665330 MINT-4793467 MINT-8380636 MINT-4049616 MINT-4054304 MINT-7905142 MINT-8385480 MINT-7013780 MINT-6540889 MINT-8385531 MINT-8385552 MINT-8385886 MINT-8388795 MINT-8415355 MINT-6540807 MINT-8391984 MINT-7905326 MINT-6540796 I2D: score=12 STRING: ENSP00000417281
    OTUB1Q96FW11, 2, 3EBI-366083,EBI-1058491 MINT-8380020 MINT-8380061 MINT-8380636 MINT-8380008 MINT-8380032 MINT-8388795 MINT-8380053 MINT-8388765 I2D: score=1 
    HNRNPUL1Q9BUJ22, 3, ENSP000003758634MINT-58678 MINT-58677 MINT-58673 MINT-58674 MINT-58676 MINT-58675 MINT-8415355 MINT-58672 I2D: score=3 STRING: ENSP00000375863
    UBCP0CG481, 2, 3, ENSP000003448184EBI-366083,EBI-3390054 MINT-7220023 MINT-4051326 MINT-4304004 MINT-4054804 MINT-4304143 MINT-6801380 MINT-6615153 MINT-6541035 MINT-7299234 MINT-7298704 MINT-6799774 MINT-7013815 MINT-4052207 MINT-7219995 MINT-5114741 I2D: score=5 STRING: ENSP00000344818
    PSME3P612891, 2, 3, ENSP000002933624EBI-366083,EBI-355546 MINT-6540807 MINT-6540940 MINT-6540866 MINT-6540920 MINT-6540876 MINT-6540776 MINT-6541016 MINT-6540960 MINT-6540796 I2D: score=3 STRING: ENSP00000293362
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 102):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IEA--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS19749791
    GO:0000733DNA strand renaturation IDA8183576
    GO:0001701in utero embryonic development IEA--
    GO:0001756somitogenesis IEA--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for TP53
    Selected ApexBio Compounds for TP53 (see all 15)     About this table
    CompoundAction CAS #
    AMG232potent and selective piperidinone inhibitor of the MDM2-p53 interaction--
    CP 31398 dihydrochloridep53 stabilizing agent. [1217195-61-3]
    JNJ-26854165 (Serdemetan)p53 activator, blocking Mdm2-p53 interaction[881202-45-5]
    Nutlin-3inhibitor of the MDM2/p53 interaction[890090-75-2]
    Nutlin-3a chiralinhibits the MDM2-p53 interaction and activates p53. [675576-98-4]
    p53 and MDM2 proteins-interaction-inhibitor chiralinhibitor of the interaction between p53 and MDM2 proteins[939981-37-0]
    Pifithrin-miuInhibits p53 binding to mitochondria[64984-31-2]
    PRIMA-1Cell-permeable BAX inhibitor, restore p53 activity[5608-24-2]
    PRIMA-1METCell-permeable BAX inhibitor, restore p53 activity[5291-32-7]
    RG7112Restoration of p53 activity by inhibiting the p53-MDM2 interaction[939981-39-2]

    Compounds for TP53 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PRIMA-1METRestores mutant p53 activity[5291-32-7]
    Pifithrin-alpha hydrobromidep53 inhibitor. Also aryl hydrocarbon receptor agonist[63208-82-2]
    RITAMDM2-p53 interaction inhibitor[213261-59-7]
    Cyclic Pifithrin-alpha hydrobromidep53 inhibitor[511296-88-1]
    Pifithrin-muInhibitor of p53-mitochondrial binding[64984-31-2]

    1 DrugBank Compound for TP53    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for TP53 gene (see all 117)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraffin 76.9 382 8640471 (4), 7726729 (4), 8434637 (4), 15363320 (4) (see all 99)
    cisplatin 74 1151 12492119 (9), 9811465 (8), 18064040 (7), 14513366 (7) (see all 99)
    noxa 72.7 89 17216584 (4), 17653088 (3), 20160496 (3), 15598651 (3) (see all 52)
    hpvs 71.4 72 20200430 (2), 11002226 (2), 8726818 (2), 9714244 (1) (see all 50)
    estrogen 71 898 14595509 (6), 9744308 (5), 10719737 (4), 15312749 (4) (see all 99)
    progesterone 69.1 712 12416559 (6), 14595509 (5), 9635673 (5), 9744308 (5) (see all 99)
    doxorubicin 67.6 464 15116093 (6), 18263706 (6), 8988061 (5), 11745235 (5) (see all 99)
    aflatoxin b1 63.4 212 16280384 (6), 8921985 (5), 19524575 (5), 1310637 (5) (see all 90)
    5fluorouracil 63.2 456 17634554 (12), 11044365 (7), 14703431 (7), 19810096 (6) (see all 99)
    camptothecin 63.1 172 10536167 (6), 9815856 (5), 19445707 (4), 17709397 (3) (see all 75)

    5 PharmGKB related drug/compound annotations for TP53 gene    About this table
    Drug/compound PharmGKB Annotation
    antineoplastic agentsCA  
    cisplatinCA  
    cyclophosphamideCA  
    fluorouracilCA  
    paclitaxelCA  



    Find genes that share compounds with TP53           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for TP53 gene (15 alternative transcripts): 
    NM_000546.5  NM_001126112.2  NM_001126113.2  NM_001126114.2  NM_001126115.1  NM_001126116.1  NM_001126117.1  NM_001126118.1  
    NM_001276695.1  NM_001276696.1  NM_001276697.1  NM_001276698.1  NM_001276699.1  NM_001276760.1  NM_001276761.1  

    Unigene Cluster for TP53:

    Tumor protein p53
    Hs.437460  [show with all ESTs]
    Unigene Representative Sequence: NM_001126114
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413465(uc002gig.1) ENST00000359597(uc002gih.3) ENST00000504290(uc010cnf.1)
    ENST00000510385(uc010cng.1) ENST00000504937(uc010cne.1 uc002gii.1)
    ENST00000269305(uc002gim.2 uc002gij.2 uc002gin.2 uc002gio.2 uc010cnk.1)
    ENST00000455263(uc010cnh.1) ENST00000420246(uc010cni.1) ENST00000445888
    ENST00000576024 ENST00000509690(uc010cnj.1) ENST00000514944 ENST00000574684
    ENST00000505014(uc010vug.2) ENST00000508793 ENST00000604348 ENST00000503591

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TP53 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TP53 (see all 17):
    hsa-miR-576-3p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-98 hsa-miR-22
    SwitchGear 3'UTR luciferase reporter plasmidTP53 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TP53
    Predesigned siRNA for gene silencing in human, mouse, rat TP53
    Clone
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    OriGene clones in human, mouse for TP53 (see all 37)
    OriGene ORF clones in mouse, rat for TP53
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): TP53 (NM_000546)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TP53
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TP53
    Addgene plasmids for TP53 
    Primer
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    OriGene qPCR primer pairs and template standards for TP53
    OriGene qSTAR qPCR primer pairs in human, mouse for TP53
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TP53
      QuantiTect SYBR Green Assays in human, mouse, rat TP53
      Search QuantiFast Probe-based Assays in human, mouse, rat TP53
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11152 VA6-13337) for TP53 

    Additional mRNA sequence: 

    AB082923.1 AF052180.1 AF307851.1 AK223026.1 AK225838.1 AK297462.1 AK297927.1 AK312568.1 
    AM076970.1 AM076971.1 AM076972.1 AY429684.1 BC003596.1 BT019622.1 DQ186648.1 DQ186649.1 
    DQ186650.1 DQ186651.1 DQ186652.1 DQ191317.1 DQ263704.1 DQ286964.1 DQ401704.1 DQ485152.1 
    DQ648884.1 DQ648885.1 DQ648886.1 DQ648887.1 EF101867.1 EF101868.1 EF101869.1 FJ207420.1 
    JN900492.1 M14694.1 M14695.1 S66666.1 X01405.1 X02469.1 X60010.1 X60011.1 
    X60012.1 X60013.1 X60014.1 X60015.1 X60016.1 X60017.1 X60018.1 X60019.1 
    X60020.1 

    16 DOTS entries:

    DT.92469229  DT.100788714  DT.120961435  DT.100788713  DT.40283865  DT.75152217  DT.95274968  DT.100712946 
    DT.120961349  DT.40120491  DT.100788719  DT.120961395  DT.92010563  DT.100788715  DT.120961350  DT.120961391 

    Selected AceView cDNA sequences (see all 112):

    AY627884 X02469 BU174921 CK904490 AA662570 X60018 BX952582 AW865736 
    CR624912 X60012 CA432254 BQ057682 CR608294 AA291539 AA379547 BU673953 
    S66666 BQ066009 AI539544 BE886147 X60016 AA358870 X60017 BE300855 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TP53 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
    SP1:                                -                             -           -     -                           
    SP2:                                                              -                                             
    SP3:                                                              -           -                                 
    SP4:                                                              -           -     -                           
    SP5:                                                                          -     -                           


    ECgene alternative splicing isoforms for TP53

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TP53 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGAGCCGC
    TP53 Expression
    About this image


    TP53 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Peripheral blood-derived endothelial progenitor cells
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Neural Crest (Gastrulation Derivatives)
             Cranial Neural Crest Cells Cranial Neural Crest
     
     Inner Cell Mass (Early Embryonic Tissues)
             20D17
     
     Kidney (Urinary System)
             Metanephros
    TP53 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TP53 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437460

    UniProtKB/Swiss-Prot: P53_HUMAN, P04637
    Tissue specificity: Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent
    manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal
    brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung,
    spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is
    not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow,
    testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain,
    heart, lung, fetal liver, salivary gland, breast or intestine

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TP53 (see all 37): 
              Lung Cancer in human mouse rat
              Lymphoma in human mouse rat
              Prostate Cancer in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TP53
    OriGene qSTAR qPCR primer pairs in human, mouse for TP53
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TP53
    QuantiTect SYBR Green Assays in human, mouse, rat TP53
    Search QuantiFast Probe-based Assays in human, mouse, rat TP53
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TP53

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for TP53 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trp531 , 5 transformation related protein 531, 5 80.62(n)1
    78.55(a)1
      11 (42.83 cM)5
    220591  NM_011640.31  NP_035770.21 
     695803595 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    44(a)
    many ↔ many
    AAWZ02038700(4261-10723)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.209432 Xenopus laevis transcribed sequence with weak similarity more 78.01(n)    BU152764.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tp532 tumor protein p53 74.13(n)   30590  AF365873.1 


    ENSEMBL Gene Tree for TP53 (if available)
    TreeFam Gene Tree for TP53 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for TP53 gene
    TP732  TP632  
    3 SIMAP similar genes for TP53 using alignment to 109 protein entries:     P53_HUMAN (see all proteins):
    p53    TP63    TP73

    Find genes that share paralogs with TP53           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for TP53 (see all 2063)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs178814701,2,,4
    CA familial cancer not matching LFS4 --7563133(-) CTCACT/GCCAGG 22 /A /S ut31 mis1 ese33Minor allele frequency- G:0.01NS NA 184
    rs178822521,2,,4
    C,F,HA sporadic cancer4 --7563214(-) GCTTCG/AAGATG 22 /K /E ut31 mis17Minor allele frequency- A:0.01NS EA NA 674
    rs558195191,2,,4
    CLi-Fraumeni syndrome (LFS)4 --7566271(+) TCTTGC/TGGAGA 30 H R mis10--------
    rs289345741,2,,4
    CLi-Fraumeni syndrome (LFS)4 pathogenic17566296(-) GAGACC/TGGCGC 30 R W mis1 ese30--------
    rs289345761,2,,4
    CLi-Fraumeni syndrome (LFS)4 pathogenic17566322(-) GGTGCA/GTGTTT 30 H R mis1 ese30--------
    rs289345771,2,,4
    CLi-Fraumeni syndrome (LFS)4 pathogenic17566713(-) CACACA/TGGAAG 30 Q L mis1 ese30--------
    rs289345711,2,,4
    CSporadic cancers4 other17566736(-) CGGAGG/TCCCAT 30 R S mis1 ese30--------
    rs115406521,2,,4
    CLi-Fraumeni syndrome (LFS)4 pathogenic17566740(-) GAACCA/GGAGGC 30 Q R mis1 ese30--------
    rs289345751,2,,4
    CLi-Fraumeni syndrome (LFS)4 pathogenic17566750(-) TGGGCA/G/TGCATG 45 S G C mis1 ese30--------
    rs289345731,2,,4
    CLi-Fraumeni syndrome (LFS)4 pathogenic17566761(-) CAGTTC/TCTGCA 30 S F mis1 ese30--------

    HapMap Linkage Disequilibrium report for TP53 (7565097 - 7590863 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TP53:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv457659CNV Loss19166990

    Human Gene Mutation Database (HGMD): TP53
    Locus Specific Mutation Databases (LSDB): TP53

    Selected Site Specific Mutation Identification with PCR Assays for TP53 (see all 120):
    Cosmic IdAA Change
    10812p.S241F
    10856p.E294*
    11089p.I195T
    10889p.H179R
    43559p.V173L
    Selected Site Specific Cancer Mutation PCR Panels containing TP53 (see all 22):
    Breast Cancer
    Cancer Comprehensive Panel 384HT
    Lung Cancer
    Myelodysplastic Syndromes
    Soft Tissue Tumors
    2 Copy Number PCR Panels containing TP53:
    Oncogenes & Tumor Suppressor Genes 384HC
    WNT Signaling
    SeqTarget long-range PCR primers for resequencing TP53
    DNA2.0 Custom Variant and Variant Library Synthesis for TP53

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 191170   
    OMIM disorders: 114500  151623  114550  259500  260500  607107  260350  202300  114480  614740  137800  
    UniProtKB/Swiss-Prot: P53_HUMAN, P04637
  • Note=TP53 is found in increased amounts in a wide variety of transformed cells. TP53 is frequently
    mutated or inactivated in about 60% of cancers. TP53 defects are found in Barrett metaplasia a condition in which
    the normally stratified squamous epithelium of the lower esophagus is replaced by a metaplastic columnar
    epithelium. The condition develops as a complication in approximately 10% of patients with chronic
    gastroesophageal reflux disease and predisposes to the development of esophageal adenocarcinoma
  • Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are
    esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease
    because it is usually not detected until it has progressed to an advanced incurable stage. Note=The disease is
    caused by mutations affecting the gene represented in this entry
  • Li-Fraumeni syndrome (LFS) [MIM:151623]: Autosomal dominant familial cancer syndrome that in its classic
    form is defined by the existence of a proband affected by a sarcoma before 45 years with a first degree relative
    affected by any tumor before 45 years and another first degree relative with any tumor before 45 years or a
    sarcoma at any age. Other clinical definitions for LFS have been proposed (PubMed:8118819 and PubMed:8718514) and
    called Li-Fraumeni like syndrome (LFL). In these families affected relatives develop a diverse set of
    malignancies at unusually early ages. Four types of cancers account for 80% of tumors occurring in TP53 germline
    mutation carriers: breast cancers, soft tissue and bone sarcomas, brain tumors (astrocytomas) and adrenocortical
    carcinomas. Less frequent tumors include choroid plexus carcinoma or papilloma before the age of 15,
    rhabdomyosarcoma before the age of 5, leukemia, Wilms tumor, malignant phyllodes tumor, colorectal and gastric
    cancers. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting
    the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.
    Note=The gene represented in this entry is involved in disease pathogenesis
  • Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form
    of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes:
    squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced
    stage and has a poor prognosis. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • Papilloma of choroid plexus (CPP) [MIM:260500]: A benign tumor of neuroectodermal origin that generally
    occurs in childhood, but has also been reported in adults. Although generally found within the ventricular
    system, choroid plexus papillomas can arise ectopically in the brain parenchyma or disseminate throughout the
    neuraxis. Patients present with signs and symptoms of increased intracranial pressure including headache,
    hydrocephalus, papilledema, nausea, vomiting, cranial nerve deficits, gait impairment, and seizures. Note=The
    disease is caused by mutations affecting the gene represented in this entry
  • Adrenocortical carcinoma (ADCC) [MIM:202300]: A malignant neoplasm of the adrenal cortex and a rare
    childhood tumor. It occurs with increased frequency in patients with Beckwith-Wiedemann syndrome and Li-Fraumeni
    syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Basal cell carcinoma 7 (BCC7) [MIM:614740]: A common malignant skin neoplasm that typically appears on
    hair-bearing skin, most commonly on sun-exposed areas. It is slow growing and rarely metastasizes, but has
    potentialities for local invasion and destruction. It usually develops as a flat, firm, pale area that is small,
    raised, pink or red, translucent, shiny, and waxy, and the area may bleed following minor injury. Tumor size can
    vary from a few millimeters to several centimeters in diameter. Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry

  • Selected diseases for TP53 (see all 149):    
    About MalaCards
    hepatocellular carcinoma    osteosarcoma    cystic teratoma    adrenocortical carcinoma
    intestinal disease    li-fraumeni syndrome    choroid plexus papilloma    basaloid squamous cell carcinoma
    ovarian cystic teratoma    atrophy of prostate    gastrointestinal adenoma    breast apocrine carcinoma
    breast adenoma    multifocal osteogenic sarcoma    pancreatic serous cystadenoma    glioma susceptibility 1
    hepadnavirus infection    meningothelial meningioma    eyelid neoplasm    basal cell carcinoma 7

    Selected diseases from the University of Copenhagen DISEASES database for TP53 (see all 52):
    Carcinoma     Breast cancer     Li-Fraumeni syndrome     Lung cancer
    Retinoblastoma     Colorectal cancer     Malignant glioma     Ovarian cancer
    Urinary bladder cancer     Adenoma     Leukemia     Cervical cancer
    Lymphoma     Hepatocellular carcinoma     Skin cancer     Esophageal cancer
    Endometrial cancer     Melanoma     Pancreatic cancer     Prostate cancer

    Find genes that share disorders with TP53           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TP53 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 93.8 24003 8777377 (10), 7901994 (9), 8007011 (9), 8324748 (8) (see all 99)
    li-fraumeni syndrome 90.7 344 1373881 (5), 17483435 (3), 10980596 (3), 10484981 (3) (see all 99)
    cancer 90.2 7050 17598983 (10), 18223686 (8), 15055300 (7), 12561442 (7) (see all 99)
    carcinoma 87.5 3357 9110348 (10), 8062281 (9), 16033093 (8), 7927312 (8) (see all 99)
    carcinoma squamous cell 86.8 1909 9127380 (8), 8826924 (7), 10445528 (6), 11255264 (6) (see all 99)
    retinoblastoma 85.1 701 10792093 (8), 9337350 (6), 11306502 (5), 8224613 (5) (see all 99)
    microsatellite instability 85 363 9731891 (6), 9716224 (5), 11290569 (5), 12612901 (5) (see all 99)
    allelic loss 83.7 407 16293976 (5), 7909153 (5), 8467510 (4), 11520271 (4) (see all 99)
    adenocarcinoma 82.7 1551 12823203 (7), 17982662 (7), 9379505 (6), 10674608 (6) (see all 99)
    breast cancer 81.9 2818 7917542 (8), 8679460 (8), 12170762 (7), 15566648 (6) (see all 99)

    GeneTests: TP53
    GeneReviews: TP53
    Genetic Association Database (GAD): TP53
    Human Genome Epidemiology (HuGE) Navigator: TP53 (1074 documents)
    Tumor Gene Database (TGDB): TP53

    Export disorders for TP53 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TP53 gene, integrated from 10 sources (see all 15580):
    (articles sorted by number of sources associating them with TP53)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a human p53 cDNA clone: expression of the human p53 gene. (PubMed id 6396087)1, 2, 3 Matlashewski G....Benchimol S. (EMBO J. 1984)
    2. Potential increase in the prognostic value of p53 mutation by Pro72 allele in stage I non-small-cell lung cancer. (PubMed id 19434453)1, 4, 9 Chien W.P....Lee H. (Ann. Surg. Oncol. 2009)
    3. Mutations in p53, p53 protein overexpression and breast cancer survival. (PubMed id 19602056)1, 4, 9 Rossner P....Santella R.M. (J. Cell. Mol. Med. 2009)
    4. TP53 mutations in endometrial cancers: relation to PTEN gene defects. (PubMed id 20169661)1, 4, 9 Janiec-Jankowska A....NajmoA8a U. (Int. J. Gynecol. Cancer 2010)
    5. Using whole genome amplification (WGA) of low-volume biopsies to assess the prognostic role of EGFR, KRAS, p53, and CMET mutations in advanced-stage non-small cell lung cancer (NSCLC). (PubMed id 19096301)1, 4, 9 Lim E.H....Tan P. (J Thorac Oncol 2009)
    6. FAK overexpression and p53 mutations are highly correlated in human breast cancer. (PubMed id 19521985)1, 4, 9 Golubovskaya V.M....Cance W.G. (Int. J. Cancer 2009)
    7. [Mutations of p53 gene in 41 cases of human brain gliomas]. (PubMed id 18184456)1, 4, 9 Cui W....Wang X.C. (Ai Zheng 2008)
    8. Association of p53 and p21(CDKN1A/WAF1/CIP1) polymorphisms with oral cancer in Taiwan patients. (PubMed id 17595776)1, 4, 9 Bau D.T....Tsai F.J. (Anticancer Res. 2007)
    9. TP53 mutations in breast cancer tumors of patients from Rio de Janeiro, Brazil: association with risk factors and tumor characteristics. (PubMed id 12209590)1, 4, 9 SimALo T.A....de Moura-Gallo C.V. (Int. J. Cancer 2002)
    10. Mutations in the p53 tumor suppressor gene and early onset breast cancer. (PubMed id 12170762)1, 4, 9 Lai H....Meng L. (amp 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7157 HGNC: 11998 AceView: TP53 Ensembl:ENSG00000141510 euGenes: HUgn7157
    ECgene: TP53 Kegg: 7157 H-InvDB: TP53

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TP53 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TP53 Genetics and Cytogenetics in Oncology and Haematology
    IARC TP53 mutation databasehttp://www-p53.iarc.fr/
    The TP53 mutant web sitehttp://p53.fr/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=TP53[genesymbol]
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tp53/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=TP53
    Wikipedia http://en.wikipedia.org/wiki/P53

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TP53 gene:
    Search GeneIP for patents involving TP53

    Licensable Technologies for TP53 gene:
    Weizmann Institute:Treatment of Systemic Lupus Erythematosus by Down-Regulating the Autoimmune Response to Autoantigens    (see all 2)
     Salk Institute: Assays for p53 Function in Cells
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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