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TP53 Gene(Protein Coding)

Tumor Protein P53

GCID:
GC17M007661
GIFtS:
77
Genes Participants
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Aliases for TP53 Gene

Aliases for TP53 Gene

  • Tumor Protein P53 2 3 5
  • Phosphoprotein P53 3 4
  • Antigen NY-CO-13 3 4
  • P53 3 4
  • Transformation-Related Protein 53 3
  • Cellular Tumor Antigen P53 3
  • Mutant Tumor Protein 53 3
  • Li-Fraumeni Syndrome 2
  • P53 Tumor Suppressor 3
  • Tumor Suppressor P53 4
  • Tumor Supressor P53 3
  • Tumor Protein 53 3
  • TRP53 3
  • BCC7 3
  • LFS1 3

External Ids for TP53 Gene

Previous GeneCards Identifiers for TP53 Gene

  • GC17P008026
  • GC17M008311
  • GC17M007514
  • GC17M007772
  • GC17M007512
  • GC17M007565
  • GC17M007465

Summaries for TP53 Gene

Entrez Gene Summary for TP53 Gene

  • This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

CIViC summary for TP53 Gene

  • TP53 mutations are universal across cancer types. Loss of tumor suppressors is most recognized by large deleterious events, such as frameshift mutations, or premature stop codons. In TP53 however, many of the observed mutations in cancer are found to be single nucleotide variants, or missense mutations. These variants are broadly distributed throughout the gene, with majority localizing in DNA binding domain. There is no single hotspot in DNA binding domain, majority of mutations occur in the following AA: 175, 245, 248, 273, 282 (NM_000546). While a large proportion of cancer genomics research is focused on somatic variants, TP53 is also of note in the germline. Germline TP53 mutations are the hallmark of Li-Fraumeni syndrome, and many (both germline and somatic) have been found to have prognostic impact on patient outcomes. The significance of many polymorphisms in susceptibility and prognosis of disease is still very much up for debate.

GeneCards Summary for TP53 Gene

TP53 (Tumor Protein P53) is a Protein Coding gene. Diseases associated with TP53 include Li-Fraumeni Syndrome and Choroid Plexus Papilloma. Among its related pathways are Development IGF-1 receptor signaling and DNA Double-Strand Break Repair. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is TP73.

UniProtKB/Swiss-Prot for TP53 Gene

  • Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).

Tocris Summary for TP53 Gene

  • p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (e.g. hypoxia, DNA and spindle damage). Activation of p53 occurs by several mechanisms including phosphorylation by ATM, ATR, Chk1 and MAPKs.

Gene Wiki entry for TP53 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP53 Gene

Genomics for TP53 Gene

Products:

  1. Regulatory Element

Regulatory Elements for TP53 Gene

Enhancers for TP53 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G007625 1.1 ENCODE 11.7 +59.3 59327 5.8 PKNOX1 SIN3A ARID4B DMAP1 ZBTB7B YY1 ZNF416 SP3 MXD4 NFYC SAT2 CHRNB1 DVL2 TP53 WRAP53 EFNB3 SENP3 DNAH2 CNTROB KCNAB3
GH17G007613 1 ENCODE 11.6 +73.0 72989 2.9 HDGF PKNOX1 ARID4B SIN3A YY1 ZNF143 ZNF207 ZNF548 FOS SP3 DVL2 SNORD10 PFAS SNORA48 CTC1 CNTROB ENSG00000265749 TNFSF12 PER1 SOX15
GH17G007684 1.4 ENCODE dbSUPER 0.7 +0.8 765 5.5 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 SENP3 ZBTB4 LOC100996842 NEURL4 DNAH2 ATP1B2 DVL2 EFNB3 NLGN2 ALOX15B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TP53 on UCSC Golden Path with GeneCards custom track

Promoters for TP53 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090892 350 3601 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21

Transcription factor binding sites by QIAGEN in the TP53 gene promoter:

Genomic Location for TP53 Gene

Chromosome:
17
Start:
7,661,779 bp from pter
End:
7,687,550 bp from pter
Size:
25,772 bases
Orientation:
Minus strand

Genomic View for TP53 Gene

Genes around TP53 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TP53 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TP53 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TP53 Gene

Proteins for TP53 Gene

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  3. Assay

  • Protein details for TP53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04637-P53_HUMAN
    Recommended name:
    Cellular tumor antigen p53
    Protein Accession:
    P04637
    Secondary Accessions:
    • Q15086
    • Q15087
    • Q15088
    • Q16535
    • Q16807
    • Q16808
    • Q16809
    • Q16810
    • Q16811
    • Q16848
    • Q2XN98
    • Q3LRW1
    • Q3LRW2
    • Q3LRW3
    • Q3LRW4
    • Q3LRW5
    • Q86UG1
    • Q8J016
    • Q99659
    • Q9BTM4
    • Q9HAQ8
    • Q9NP68
    • Q9NPJ2
    • Q9NZD0
    • Q9UBI2
    • Q9UQ61

    Protein attributes for TP53 Gene

    Size:
    393 amino acids
    Molecular mass:
    43653 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1 (By similarity). Binds DNA as a homotetramer. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. In vitro, the interaction of TP53 with cancer-associated/HPV (E6) viral proteins leads to ubiquitination and degradation of TP53 giving a possible model for cell growth regulation. This complex formation requires an additional factor, E6-AP, which stably associates with TP53 in the presence of E6. Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1. Interacts with WWOX. May interact with HCV core protein. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity (By similarity). Interacts with ARMC10, BANP, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F1. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on Ser-58 inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation. Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-382) with L3MBTL1. Isoform 1 interacts with isoform 2 and with isoform 4. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with AURKB, SETD2, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2. Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by cyclosporin A (CsA). Interacts with human cytomegalovirus/HHV-5 protein UL123. Interacts with SNAI1; the interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion. Interacts with KAT6A. Interacts with UBC9. Interacts with ZNF385B; the interaction is direct. Interacts (via DNA-binding domain) with ZNF385A; the interaction is direct and enhances p53/TP53 transactivation functions on cell-cycle arrest target genes, resulting in growth arrest. Interacts with ANKRD2. Interacts with RFFL and RNF34; involved in p53/TP53 ubiquitination. Interacts with MTA1 and RFWD2. Interacts with CCAR2 (via N-terminus). Interacts (via N-terminus) with human adenovirus 5 E1B-55K protein; this interaction leads to the inhibition of TP53 function and/or its degradation (PubMed:25772236). Interacts with MORC3 (PubMed:17332504). Interacts (via C-terminus) with POU4F2 isoform 1 (via C-terminus) (PubMed:17145718).

    Three dimensional structures from OCA and Proteopedia for TP53 Gene

    Alternative splice isoforms for TP53 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TP53 Gene

Protein Expression for TP53 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TP53 Gene

  • Acetylated. Acetylation of Lys-382 by CREBBP enhances transcriptional activity. Deacetylation of Lys-382 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylation by SIRT2 impairs its ability to induce transcription activation in a AKT-dependent manner.
  • Dephosphorylated by PP2A-PPP2R5C holoenzyme at Thr-55. SV40 small T antigen inhibits the dephosphorylation by the AC form of PP2A.
  • May be O-glycosylated in the C-terminal basic region. Studied in EB-1 cell line.
  • Monomethylated at Lys-372 by SETD7, leading to stabilization and increased transcriptional activation. Monomethylated at Lys-370 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity. Lys-372 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-370. Dimethylated at Lys-373 by EHMT1 and EHMT2. Monomethylated at Lys-382 by KMT5A, promoting interaction with L3MBTL1 and leading to repress transcriptional activity. Dimethylation at Lys-370 and Lys-382 diminishes p53 ubiquitination, through stabilizing association with the methyl reader PHF20. Demethylation of dimethylated Lys-370 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation.
  • Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylated by HIPK1 (By similarity). Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter. Phosphorylated on Thr-18 by VRK1. Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2. Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis. Phosphorylated on Thr-55 by TAF1, which promotes MDM2-mediated degradation. Phosphorylated on Ser-33 by CDK7 in a CAK complex in response to DNA damage. Phosphorylated on Ser-46 by HIPK2 upon UV irradiation. Phosphorylation on Ser-46 is required for acetylation by CREBBP. Phosphorylated on Ser-392 following UV but not gamma irradiation. Phosphorylated on Ser-15 upon ultraviolet irradiation; which is enhanced by interaction with BANP. Phosphorylated by NUAK1 at Ser-15 and Ser-392; was intially thought to be mediated by STK11/LKB1 but it was later shown that it is indirect and that STK11/LKB1-dependent phosphorylation is probably mediated by downstream NUAK1 (PubMed:21317932). It is unclear whether AMP directly mediates phosphorylation at Ser-15. Phosphorylated on Thr-18 by isoform 1 and isoform 2 of VRK2. Phosphorylation on Thr-18 by isoform 2 of VRK2 results in a reduction in ubiquitination by MDM2 and an increase in acetylation by EP300. Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated by DYRK2 at Ser-46 in response to genotoxic stress. Phosphorylated at Ser-315 and Ser-392 by CDK2 in response to DNA-damage.
  • Sumoylated with SUMO1. Sumoylated at Lys-386 by UBC9.
  • Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation (PubMed:10722742, PubMed:12810724, PubMed:15340061, PubMed:17170702, PubMed:19880522). Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome (PubMed:10722742, PubMed:12810724, PubMed:20173098). Ubiquitinated by MKRN1 at Lys-291 and Lys-292, which leads to proteasomal degradation (PubMed:19536131). Deubiquitinated by USP10, leading to its stabilization (PubMed:20096447). Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation (PubMed:19556538). Ubiquitination by TOPORS induces degradation (PubMed:19473992). Deubiquitination by USP7, leading to stabilization (PubMed:15053880). Isoform 4 is monoubiquitinated in an MDM2-independent manner (PubMed:15340061). Ubiquitinated by RFWD2, which leads to proteasomal degradation (PubMed:19837670). Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 (PubMed:25732823).
  • Ubiquitination at isoforms=2, 3, 4, 5, 6101, Lys132, posLast=164164, posLast=291291, Lys292, isoforms=2, 3, 4, 5, 6, 7, 8, 9305, isoforms=4, 7320, and isoforms=4, 7321
  • Modification sites at PhosphoSitePlus

Other Protein References for TP53 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TP53 (p53)

Assay Products

  • Enzo Life Sciences assays for TP53

No data available for DME Specific Peptides for TP53 Gene

Domains & Families for TP53 Gene

Protein Domains for TP53 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TP53 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04637

UniProtKB/Swiss-Prot:

P53_HUMAN :
  • The nuclear export signal acts as a transcriptional repression domain. The TADI and TADII motifs (residues 17 to 25 and 48 to 56) correspond both to 9aaTAD motifs which are transactivation domains present in a large number of yeast and animal transcription factors.
  • Belongs to the p53 family.
Domain:
  • The nuclear export signal acts as a transcriptional repression domain. The TADI and TADII motifs (residues 17 to 25 and 48 to 56) correspond both to 9aaTAD motifs which are transactivation domains present in a large number of yeast and animal transcription factors.
Family:
  • Belongs to the p53 family.
genes like me logo Genes that share domains with TP53: view

No data available for Gene Families for TP53 Gene

Function for TP53 Gene

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Molecular function for TP53 Gene

GENATLAS Biochemistry:
tumor suppressor protein p53 required for G1 growth arrest by WAF1 (CDKN1A),following DNA damage or induction of apoptosis,also regulating a G2 checkpoint through cyclin B1,transcriptional activator through acetylation of transactivation site by CREBBP binding MDM2 resulting in transcriptional silencing and ubiquitin/proteasome dependent degradation of p53,activated by conjugation to UBL1 (SUMO1),putative up-regulated c-MYC target gene,putative teratologic suppressor gene and modulator of TFIIH (GTF2H),associated in nucleotide excision repair,activated by ATM in association with 14.3.3 proteins (YWHA*),tumor suppressor gene (see TSG17A),mutated in cancers such as pancreas and endometrial carcinomas,in Barretts adenocarcinoma (and esophageal squamous cell carcinoma),in hepatocellular carcinoma with poor prognosis
UniProtKB/Swiss-Prot Function:
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to DNA damage. Isoform 2 is not induced in tumor cells in response to stress.

Gene Ontology (GO) - Molecular Function for TP53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 24289924
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA 17310983
GO:0000990 transcription factor activity, core RNA polymerase binding IDA 15314173
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0001085 RNA polymerase II transcription factor binding IPI 18549481
genes like me logo Genes that share ontologies with TP53: view
genes like me logo Genes that share phenotypes with TP53: view

Human Phenotype Ontology for TP53 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TP53 Gene

MGI Knock Outs for TP53:

Animal Model Products

CRISPR Products

miRNA for TP53 Gene

miRTarBase miRNAs that target TP53

Transcription Factor Targets for TP53 Gene

Selected GeneGlobe predicted Target genes for TP53
Targeted motifs for TP53 Gene
HOMER Transcription Factor Regulatory Elements motif TP53
  • Consensus sequence: AACATGCCCAGACATGCCCN Submotif: canonical Cell Type: Saos GEO ID: GSE15780

Clone Products

  • Addgene plasmids for TP53

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) for TP53 Gene

Localization for TP53 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP53 Gene

Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Translocates to mitochondria upon oxidative stress.
Isoform 1: Nucleus. Cytoplasm. Note=Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4.
Isoform 2: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in the cytoplasm.
Isoform 3: Nucleus. Cytoplasm. Note=Localized in the nucleus in most cells but found in the cytoplasm in some cells.
Isoform 4: Nucleus. Cytoplasm. Note=Predominantly nuclear but translocates to the cytoplasm following cell stress.
Isoform 7: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in the cytoplasm.
Isoform 8: Nucleus. Cytoplasm. Note=Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli.
Isoform 9: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TP53 gene
Compartment Confidence
mitochondrion 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
plasma membrane 3
extracellular 3
cytoskeleton 3
peroxisome 2
lysosome 2
endosome 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TP53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 15710329
GO:0005622 intracellular IDA 16213212
GO:0005634 nucleus IDA,IEA 7720704
GO:0005654 nucleoplasm TAS,IDA --
GO:0005657 replication fork IBA --
genes like me logo Genes that share ontologies with TP53: view

Pathways & Interactions for TP53 Gene

genes like me logo Genes that share pathways with TP53: view

Pathways by source for TP53 Gene

1 Cell Signaling Technology pathway for TP53 Gene
4 Tocris pathways for TP53 Gene

SIGNOR curated interactions for TP53 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for TP53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS 19749791
GO:0000733 DNA strand renaturation IDA 8183576
GO:0006284 base-excision repair TAS 15116721
GO:0006289 nucleotide-excision repair IMP 7663514
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TP53: view

Drugs & Compounds for TP53 Gene

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(114) Drugs for TP53 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2770
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 2935
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1856
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1967
Paclitaxel Approved, Vet_approved Pharma Tubulin and Bcl2 inhibitor, Taxanes 2864

(57) Additional Compounds for TP53 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cyclic Pifithrin-alpha hydrobromide
511296-88-1
Pifithrin-alpha hydrobromide
63208-82-2
Pifithrin-mu
64984-31-2

(5) Tocris Compounds for TP53 Gene

Compound Action Cas Number
Cyclic Pifithrin-alpha hydrobromide p53 inhibitor 511296-88-1
PhiKan 083 p53 stabilizing agent 880813-36-5
Pifithrin-alpha hydrobromide p53 inhibitor. Also aryl hydrocarbon receptor agonist 63208-82-2
Pifithrin-mu Inhibitor of p53-mitochondrial binding 64984-31-2
PRIMA-1MET Restores mutant p53 activity 5291-32-7

(31) ApexBio Compounds for TP53 Gene

Compound Action Cas Number
AMG232 p53-MDM2 inhibitor, novel 1352066-68-2
Betulinic acid Anti-HIV and antitumor compound,pentacyclic triterpenoid 472-15-1
Brassinolide Plant growth regulator 72962-43-7
CP 31398 dihydrochloride p53 stabilizer 1217195-61-3
Cyclic Pifithrin-α hydrobromide P53 inhibitor 511296-88-1
JNJ-26854165 (Serdemetan) P53 activator, blocking Mdm2-p53 interaction 881202-45-5
MI-773 (SAR405838) 1303607-60-4
MIRA-1 Restorer of wild-type p53 conformation/cellular function 72835-26-8
NSC 146109 hydrochloride Antitumor agent,p53-dependent transcription activator 59474-01-0
NSC 319726 Reactivator of mutant p53 71555-25-4
Nutlin-3 MDM2 antagonist,inhibits MDM2-p53 interaction 890090-75-2
Nutlin-3b MDM2/p53 inhibitor 675576-97-3
NVP-CGM097 1313363-54-0
ONC201 activates p53-independent apoptosis 1616632-77-9
p53 and MDM2 proteins-interaction-inhibitor chiral P53 and MDM2 proteins-interaction-inhibitor 939981-37-0
p53 and MDM2 proteins-interaction-inhibitor racemic 939983-14-9
p53/MDM2 Set I
PhiKan 083 p53 stabilizer 880813-36-5
Pifithrin-α (PFTα) p53 inhibitor 63208-82-2
Pifithrin-β 60477-34-1
Pifithrin-ÎĽ Inhibitor of p53 binding and anti-apoptotic 64984-31-2
PRIMA-1 BAX inhibitor 5608-24-2
PRIMA-1MET Restore mutant p53 activity, induce BAX and PUMA 5291-32-7
RETRA hydrochloride Antitumor agent 1036069-26-7
RG7388 MDM2 antagonist, oral, selective 1229705-06-9
RITA (NSC 652287) Mdm2-p53 interaction and p53 ubiquitination blocking 213261-59-7
Tenovin-1 SIRT2 inhibitor, activates p53 380315-80-0
Tenovin-3 1011301-27-1
Tenovin-6 SIRT inhibitor and p53 activator 1011557-82-6
WR 1065 P53/p21waf-1/MDM2 activator 14653-77-1
YH239-EE 1364488-67-4
genes like me logo Genes that share compounds with TP53: view

Drug Products

Transcripts for TP53 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for TP53 Gene

(15) REFSEQ mRNAs :
(51) Additional mRNA sequences :
(112) Selected AceView cDNA sequences:
(28) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TP53 Gene

Tumor protein p53:
Representative Sequences:

CRISPR Products

Clone Products

  • Addgene plasmids for TP53

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TP53 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
SP1: - - - -
SP2: -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - - -
SP7:
SP8: -
SP9: -

Relevant External Links for TP53 Gene

GeneLoc Exon Structure for
TP53
ECgene alternative splicing isoforms for
TP53

Expression for TP53 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TP53 Gene

mRNA expression in normal human tissues for TP53 Gene
mRNA expression by BioGPS for TP53 GenemRNA expression by GTEx for TP53 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TP53 Gene

This gene is overexpressed in Lung (40.0) and Breast (26.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TP53 Gene



Protein tissue co-expression partners for TP53 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TP53 Gene:

TP53

SOURCE GeneReport for Unigene cluster for TP53 Gene:

Hs.437460

mRNA Expression by UniProt/SwissProt for TP53 Gene:

P04637-P53_HUMAN
Tissue specificity: Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine.

Evidence on tissue expression from TISSUES for TP53 Gene

  • Nervous system(5)
  • Intestine(4.8)
  • Blood(4.7)
  • Kidney(4.6)
  • Lung(3.9)
  • Skin(3.7)
  • Lymph node(3.6)
  • Liver(3.4)
  • Stomach(3.4)
  • Bone marrow(3)
  • Heart(2.9)
  • Muscle(2.9)
  • Spleen(2.9)
  • Thyroid gland(2.9)
  • Pancreas(2.7)
  • Gall bladder(2.6)
  • Bone(2.5)
  • Adrenal gland(2.4)
  • Eye(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TP53 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • ear
  • eye
  • head
  • jaw
  • mandible
  • maxilla
  • meninges
  • mouth
  • neck
  • nose
  • pharynx
  • salivary gland
  • skull
Thorax:
  • breast
  • chest wall
  • clavicle
  • esophagus
  • heart
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • adrenal gland
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • spleen
  • stomach
Pelvis:
  • anus
  • pelvis
  • prostate
  • rectum
  • testicle
  • ureter
  • urethra
  • urinary bladder
  • uterus
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • spinal cord
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with TP53: view

Primer Products

No data available for mRNA differential expression in normal tissues for TP53 Gene

Orthologs for TP53 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TP53 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TP53 34 35
  • 99.75 (n)
dog
(Canis familiaris)
 Mammalia TP53 34
  • 84.3 (n)
P53 35
  • 81 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia TP53 34 35
  • 83.9 (n)
mouse
(Mus musculus)
 Mammalia Trp53 34 16 35
  • 80.62 (n)
rat
(Rattus norvegicus)
 Mammalia Tp53 34
  • 80.5 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia TP53 35
  • 60 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia TP53 35
  • 59 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 44 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia tp53 34
  • 59.21 (n)
Str.6676 34
African clawed frog
(Xenopus laevis)
 Amphibia Xl.20943 34
zebrafish
(Danio rerio)
 Actinopterygii tp53 34 35
  • 57.35 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 28 (a)
 ManyToMany
CSA.2527 35
  • 24 (a)
 ManyToMany
Species where no ortholog for TP53 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TP53 Gene

ENSEMBL:
Gene Tree for TP53 (if available)
TreeFam:
Gene Tree for TP53 (if available)

Paralogs for TP53 Gene

Paralogs for TP53 Gene

(3) SIMAP similar genes for TP53 Gene using alignment to 109 proteins:

genes like me logo Genes that share paralogs with TP53: view

Variants for TP53 Gene

Sequence variations from dbSNP and Humsavar for TP53 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1042522 drug-response, Sporadic cancers 7,676,154(-) TCCCC(A/C/G)CGTGG upstream-variant-2KB, reference, missense
rs112431538 Sporadic cancers 7,673,767(+) TTCCT(C/T)TGTGC reference, missense
rs11540652 Pathogenic, Li-Fraumeni syndrome (LFS) [MIM:151623] 7,674,220(-) GAACC(A/C/G/T)GAGGC reference, missense
rs11540654 Likely pathogenic, A familial cancer not matching LFS, Sporadic cancers, Sporadic cancers 7,676,040(-) TTTCC(A/C/G/T)TCTGG upstream-variant-2KB, reference, missense
rs11575996 Sporadic cancers 7,673,535(-) CTTCA(A/G/T)GTACT reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for TP53 Gene

Variant ID Type Subtype PubMed ID
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781

Variation tolerance for TP53 Gene

Residual Variation Intolerance Score: 42.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TP53 Gene

Human Gene Mutation Database (HGMD)
TP53
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TP53

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TP53 Gene

Disorders for TP53 Gene

MalaCards: The human disease database

(394) MalaCards diseases for TP53 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
li-fraumeni syndrome
  • li-fraumeni familiar cancer susceptibility syndrome
choroid plexus papilloma
  • papilloma of choroid plexus
pancreatic cancer
  • pancreatic carcinoma, somatic
osteosarcoma, somatic
  • osteosarcoma
basal cell carcinoma 7
  • bcc7
- elite association - COSMIC cancer census association via MalaCards
Search TP53 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

P53_HUMAN
  • Adrenocortical carcinoma (ADCC) [MIM:202300]: A malignant neoplasm of the adrenal cortex and a rare childhood tumor. It occurs with increased frequency in patients with Beckwith-Wiedemann syndrome and Li-Fraumeni syndrome. {ECO:0000269 PubMed:11481490}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Basal cell carcinoma 7 (BCC7) [MIM:614740]: A common malignant skin neoplasm that typically appears on hair-bearing skin, most commonly on sun-exposed areas. It is slow growing and rarely metastasizes, but has potentialities for local invasion and destruction. It usually develops as a flat, firm, pale area that is small, raised, pink or red, translucent, shiny, and waxy, and the area may bleed following minor injury. Tumor size can vary from a few millimeters to several centimeters in diameter. {ECO:0000269 PubMed:21946351}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Li-Fraumeni syndrome (LFS) [MIM:151623]: Autosomal dominant familial cancer syndrome that in its classic form is defined by the existence of a proband affected by a sarcoma before 45 years with a first degree relative affected by any tumor before 45 years and another first degree relative with any tumor before 45 years or a sarcoma at any age. Other clinical definitions for LFS have been proposed (PubMed:8118819 and PubMed:8718514) and called Li-Fraumeni like syndrome (LFL). In these families affected relatives develop a diverse set of malignancies at unusually early ages. Four types of cancers account for 80% of tumors occurring in TP53 germline mutation carriers: breast cancers, soft tissue and bone sarcomas, brain tumors (astrocytomas) and adrenocortical carcinomas. Less frequent tumors include choroid plexus carcinoma or papilloma before the age of 15, rhabdomyosarcoma before the age of 5, leukemia, Wilms tumor, malignant phyllodes tumor, colorectal and gastric cancers. {ECO:0000269 PubMed:10484981, ECO:0000269 PubMed:1565144, ECO:0000269 PubMed:1737852, ECO:0000269 PubMed:1933902, ECO:0000269 PubMed:1978757, ECO:0000269 PubMed:2259385, ECO:0000269 PubMed:7887414, ECO:0000269 PubMed:8825920, ECO:0000269 PubMed:9452042}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=TP53 is found in increased amounts in a wide variety of transformed cells. TP53 is frequently mutated or inactivated in about 60% of cancers. TP53 defects are found in Barrett metaplasia a condition in which the normally stratified squamous epithelium of the lower esophagus is replaced by a metaplastic columnar epithelium. The condition develops as a complication in approximately 10% of patients with chronic gastroesophageal reflux disease and predisposes to the development of esophageal adenocarcinoma.
  • Papilloma of choroid plexus (CPP) [MIM:260500]: A benign tumor of neuroectodermal origin that generally occurs in childhood, but has also been reported in adults. Although generally found within the ventricular system, choroid plexus papillomas can arise ectopically in the brain parenchyma or disseminate throughout the neuraxis. Patients present with signs and symptoms of increased intracranial pressure including headache, hydrocephalus, papilledema, nausea, vomiting, cranial nerve deficits, gait impairment, and seizures. {ECO:0000269 PubMed:12085209}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. Note=The gene represented in this entry is involved in disease pathogenesis.

Relevant External Links for TP53

Genetic Association Database (GAD)
TP53
Human Genome Epidemiology (HuGE) Navigator
TP53
Tumor Gene Database (TGDB):
TP53
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TP53
genes like me logo Genes that share disorders with TP53: view

No data available for Genatlas for TP53 Gene

Publications for TP53 Gene

  1. Combination of p53 codon 72 polymorphism and inactive p53 mutation predicts chemosensitivity to 5-fluorouracil in colorectal cancer. (PMID: 19810096) Tominaga T. … Yamaue H. (Int. J. Cancer 2010) 3 22 46 64
  2. p53 genotype predicts response to chemotherapy in patients with squamous cell carcinoma of the esophagus. (PMID: 19941080) Yamasaki M. … Doki Y. (Ann. Surg. Oncol. 2010) 3 22 46 64
  3. Association of TP53 codon 72 polymorphism with cervical cancer risk in Chinese women. (PMID: 20193851) Jiang P. … Tang J. (Cancer Genet. Cytogenet. 2010) 3 22 46 64
  4. TP53, MDM2, NQO1, and susceptibility to cervical cancer. (PMID: 20200430) Hu X. … Rader J.S. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 22 46 64
  5. Risk of MDM2 SNP309 alone or in combination with the p53 codon 72 polymorphism in acute myeloid leukemia. (PMID: 19423162) Xiong X. … Wang J. (Leuk. Res. 2009) 3 22 46 64

Products for TP53 Gene

  • Addgene plasmids for TP53

Sources for TP53 Gene

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