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TOX4 Gene

protein-coding   GIFtS: 50
GCID: GC14P021944

TOX High Mobility Group Box Family Member 4

(Previous names: chromosome 14 open reading frame 92, KIAA0737)
(Previous symbols: C14orf92, KIAA0737)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TOX High Mobility Group Box Family Member 41 2     LCP12 5
KIAA07371 2 3 5     Chromosome 14 Open Reading Frame 921
C14orf921 2 3     MIG72
Epidermal Langerhans Cell Protein LCP12 3     Migration-Inducing Protein 72

External Ids:    HGNC: 201611   Entrez Gene: 98782   Ensembl: ENSG000000922037   OMIM: 6140325   UniProtKB: O948423   

Export aliases for TOX4 gene to outside databases

Previous GC identifers: GC14P021017 GC14P021019 GC14P002064


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TOX4 Gene:
TOX4 (TOX high mobility group box family member 4) is a protein-coding gene. Diseases associated with TOX4 include ocular toxoplasmosis, and toxoplasmosis. An important paralog of this gene is TOX.

UniProtKB/Swiss-Prot: TOX4_HUMAN, O94842
Function: Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure
and cell cycle progression during the transition from mitosis into interphase

Gene Wiki entry for TOX4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TOX4 gene promoter:
         Max1   RP58   Pax-6   Lmo2   HNF-4alpha2   C/EBPalpha   HNF-4alpha1   HFH-1   Cart-1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTOX4 promoter sequence
   Search Chromatin IP Primers for TOX4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TOX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

TOX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOX4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021944:  view genomic region     (about GC identifiers)

Start:
21,944,756 bp from pter      End:
21,967,319 bp from pter
Size:
22,564 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TOX4_HUMAN, O94842 (See protein sequence)
Recommended Name: TOX high mobility group box family member 4  
Size: 621 amino acids; 66195 Da
Subunit: Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82 and PPP1CA or PPP1CB
or PPP1CC. Interacts with PPP1R10/PNUTS
Sequence caution: Sequence=BAA34457.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B4DPY8 E7EV69
Alternative splicing: 2 isoforms:  O94842-1   O94842-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TOX4: NX_O94842

Explore proteomics data for TOX4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TOX4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055643.1  
    ENSEMBL proteins: 
     ENSP00000402195   ENSP00000385102   ENSP00000392234   ENSP00000392482   ENSP00000406196  
     ENSP00000389333   ENSP00000262709   ENSP00000393080  

    TOX4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TOX4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TOX4
    GenScript Custom Purified and Recombinant Proteins Services for TOX4
    Novus Biologicals TOX4 Protein
    Novus Biologicals TOX4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TOX4

    TOX4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TOX4
    Novus Biologicals TOX4 Antibodies
    Abcam antibodies for TOX4
    Cloud-Clone Corp. Antibodies for TOX4
    Search ThermoFisher Antibodies for TOX4
    LSBio Antibodies in human, mouse, rat for TOX4

    TOX4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TOX4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TOX4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TOX4
    Cloud-Clone Corp. CLIAs for TOX4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009071 HMG_box_dom

    Graphical View of Domain Structure for InterPro Entry O94842

    ProtoNet protein and cluster: O94842

    UniProtKB/Swiss-Prot: TOX4_HUMAN, O94842
    Similarity: Contains 1 HMG box DNA-binding domain


    TOX4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOX4_HUMAN, O94842
    Function: Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure
    and cell cycle progression during the transition from mitosis into interphase

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
         
    TOX4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TOX4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TOX4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TOX4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TOX4

    miRNA
    Products:
        
    miRTarBase miRNAs that target TOX4:
    hsa-mir-16-5p (MIRT032057)

    Block miRNA regulation of human, mouse, rat TOX4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOX4 (see all 23):
    hsa-miR-3149 hsa-miR-100* hsa-miR-328 hsa-miR-892b hsa-miR-539 hsa-miR-331-3p hsa-miR-29b-1* hsa-miR-548g
    SwitchGear 3'UTR luciferase reporter plasmidTOX4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TOX4
    Predesigned siRNA for gene silencing in human, mouse, rat TOX4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TOX4

    Clone
    Products:
         
    OriGene clones in human, mouse for TOX4 (see all 8)
    OriGene ORF clones in mouse, rat for TOX4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOX4 (NM_014828)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOX4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TOX4
    Browse ESI BIO Cell Lines and PureStem Progenitors for TOX4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOX4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TOX4_HUMAN, O94842: Nucleus (Probable). Note=Associated with chromatin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IDA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0072357PTW/PP1 phosphatase complex IDA--

    TOX4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TOX4
    Interactions:

        Search GeneGlobe Interaction Network for TOX4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TOX4 (O948422, 3 ENSP000002627094) via UniProtKB, MINT, STRING, and/or I2D (see all 650)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CAP621362, 3, ENSP000003260314MINT-7945693 I2D: score=1 STRING: ENSP00000326031
    HIPK3Q9H4222, 3MINT-61739 I2D: score=3 
    ZNF512BQ96KM62, 3MINT-60817 I2D: score=2 
    ENSG00000238104Q96QC03, ENSP000004073104I2D: score=1 STRING: ENSP00000407310
    ENSG00000231737Q96QC03, ENSP000004071814I2D: score=1 STRING: ENSP00000407181
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TOX4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TOX4 gene: 
    NM_014828.2  

    Unigene Cluster for TOX4:

    TOX high mobility group box family member 4
    Hs.555910  [show with all ESTs]
    Unigene Representative Sequence: NM_014828
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000416256 ENST00000405508(uc001waz.3 uc010tlu.2 uc010tlv.2)
    ENST00000476180(uc001way.3) ENST00000455393 ENST00000447695 ENST00000457430
    ENST00000494242 ENST00000455138 ENST00000487242 ENST00000473176 ENST00000463119
    ENST00000262709 ENST00000448790
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TOX4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOX4 (see all 23):
    hsa-miR-3149 hsa-miR-100* hsa-miR-328 hsa-miR-892b hsa-miR-539 hsa-miR-331-3p hsa-miR-29b-1* hsa-miR-548g
    SwitchGear 3'UTR luciferase reporter plasmidTOX4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TOX4
    Predesigned siRNA for gene silencing in human, mouse, rat TOX4
    Clone
    Products:
         
    OriGene clones in human, mouse for TOX4 (see all 8)
    OriGene ORF clones in mouse, rat for TOX4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOX4 (NM_014828)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOX4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TOX4
    OriGene qSTAR qPCR primer pairs in human, mouse for TOX4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOX4
      QuantiTect SYBR Green Assays in human, mouse, rat TOX4
      QuantiFast Probe-based Assays in human, mouse, rat TOX4

    Additional mRNA sequence: 

    AB018280.1 AK022060.1 AK295913.1 AK298555.1 AK299807.1 AY305872.1 BC013689.1 BC020292.1 
    BC020727.1 BC035050.1 

    Selected DOTS entries (see all 25):

    DT.100702386  DT.444736  DT.100770645  DT.100844608  DT.75100949  DT.120763155  DT.120763081  DT.100884678 
    DT.102835219  DT.100807352  DT.100884648  DT.100884651  DT.100806117  DT.120763088  DT.120763157  DT.120763175 
    DT.120763177  DT.120763185  DT.121223751  DT.40282672  DT.100810815  DT.120763112  DT.120763166  DT.95147968 

    Selected AceView cDNA sequences (see all 407):

    CF780719 CR624614 AA446593 AI276123 BM756687 BU733080 BU527421 AA460232 
    AA234720 BM691155 AA693518 BQ948939 CD723507 AA417713 CR603862 BC020292 
    AA424238 CB140097 N49265 AI659515 AI633510 CB113626 CA390211 AI832135 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TOX4 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
    SP1:                                -     -                 -                                                                                 
    SP2:                                -                       -                                                                                 
    SP3:                                -     -           -     -                                                                                 
    SP4:                                      -                 -                                                                                 
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for TOX4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TOX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCATAGATTT
    TOX4 Expression
    About this image


    TOX4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
    TOX4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TOX4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.555910
        Custom PCR Arrays for TOX4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TOX4
    OriGene qSTAR qPCR primer pairs in human, mouse for TOX4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOX4
    QuantiTect SYBR Green Assays in human, mouse, rat TOX4
    QuantiFast Probe-based Assays in human, mouse, rat TOX4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOX4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TOX4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tox41 , 5 TOX high mobility group box family member 41, 5 89.93(n)1
    95.32(a)1
      14 (26.88 cM)5
    2687411  NM_023434.31  NP_075923.21 
     522791465 
    lizard
    (Anolis carolinensis)
    Reptilia TOX46
    TOX high mobility group box family member 4
    71(a)
    1 ↔ 1
    GL343466.1(470167-485790)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.338382 Xenopus laevis transcribed sequence with moderate similarity more 78.03(n)    BU910449.1 
    zebrafish
    (Danio rerio)
    Actinopterygii TOX4 (2 of 2)6
    tox46
    TOX high mobility group box family member 4
    46(a)
    40(a)
    1 ↔ many
    1 ↔ many
    Zv9_NA972(2070-15965) ENSDARG00000063420
    2(37770447-37783417) ENSDARG00000002031
    fruit fly
    (Drosophila melanogaster)
    Insecta CG121046
    --
    37(a)
    1 ↔ 1
    3L(1600726-1602674)
    worm
    (Caenorhabditis elegans)
    Secernentea hmg-66
    Protein HMG-6 (hmg-6) mRNA, complete cds
    32(a)
    1 ↔ 1
    I(14059411-14060829) WBGene00009827
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes POB36
    Subunit of the heterodimeric FACT complex (Spt16p-...
    5(a)
    1 → many
    XIII(135500-137158) YML069W


    ENSEMBL Gene Tree for TOX4 (if available)
    TreeFam Gene Tree for TOX4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TOX4 gene
    TOX2  SSRP12  TOX32  TOX22  
    2 SIMAP similar genes for TOX4 using alignment to 6 protein entries:     TOX4_HUMAN (see all proteins):
    TOX3    Bbtx1

    TOX4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TOX4
    PGOHUM00000246033


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TOX4 (see all 459)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880676811,2
    C--21947217(+) TGCCCA/GCCTCA 1 -- int10--------
    rs1396209201,2
    C--21947321(+) GATAA-/GTGTGAA 1 -- int10--------
    rs353574031,2
    C--21947322(+) AAGTG-/TGAATCT 1 -- int10--------
    rs1480286781,2
    --21947469(+) GGCAAC/TGTGAT 1 -- int10--------
    rs71509481,2
    C,F,A--21947531(+) GAggcC/Ggggtg 1 -- int15Minor allele frequency- G:0.40WA NA CSA 10
    rs1810189381,2
    --21947617(+) AGCCTC/GACCAA 1 -- int10--------
    rs128895461,2
    C,F--21947633(+) GAAACG/CCCATC 1 -- int14Minor allele frequency- C:0.50NA WA CSA 8
    rs71579611,2
    C--21947761(+) gagatC/Tgcgcc 1 -- int17Minor allele frequency- T:0.08NA WA CSA 13
    rs1872472941,2
    --21947762(+) AGATTA/GCGCCA 1 -- int10--------
    rs284151601,2
    --21947778(+) CTCCAC/GCCTAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for TOX4 (21944756 - 21967319 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TOX4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2080110CNV Deletion18987734
    esv994931CNV Deletion20482838
    esv2506236CNV Deletion19546169
    esv2748459CNV Deletion23290073
    esv2666055CNV Deletion23128226
    esv2422459CNV Duplication17116639
    nsv85879CNV Loss16902084
    esv8853CNV Loss19470904

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TOX4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614032    OMIM disorders: --

    5 diseases for TOX4:    
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    ocular toxoplasmosis    toxoplasmosis    ataxia    malaria
    breast cancer


    TOX4 for disorders           About GeneDecksing


    Export disorders for TOX4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TOX4 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with TOX4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel human PP1 phosphatase complex. (PubMed id 20516061)1, 2 Lee J.H.... Skalnik D.G. (J. Biol. Chem. 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PubMed id 22412018)1 Roux K.J.... Burke B. (J. Cell Biol. 2012)
    6. Differential Epigenetic Regulation of TOX Subfamily High Mobility Group Box Genes in Lung and Breast Cancers. (PubMed id 22496870)1 Tessema M.... Belinsky S.A. (PLoS ONE 2012)
    7. [Mig-7 enhances vasculogenic mimicry in gastric cancer cells]. (PubMed id 23127401)1 Li W.L. and Gao Q. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2012)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. TOX4 and its binding partners recognize DNA adducts generated by platinum anticancer drugs. (PubMed id 21184731)1 Bounaix Morand du Puch C....Breton J. (Arch. Biochem. Biophys. 2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9878 HGNC: 20161 AceView: C14orf92 Ensembl:ENSG00000092203 euGenes: HUgn9878
    ECgene: TOX4 H-InvDB: TOX4

    (According to HUGE)
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    HUGE: KIAA0737

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TOX4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TOX4 gene:
    Search GeneIP for patents involving TOX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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