TOX4 Gene
protein-coding GIFtS : 49 GCID: GC14 P021944
TOX high mobility group box family member 4 chromosome 14 open reading frame 92, KIAA0737 )C14orf92, KIAA0737 )
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Aliasesfor TOX4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases TOX High Mobility Group Box Family Member 4 1 2 Epidermal Langerhans Cell Protein LCP12 3 C14orf921 2 3 Chromosome 14 Open Reading Frame 921 KIAA07371 2 3 MIG72 LCP11 2 Migration-Inducing Protein 72
Export aliases for TOX4 gene to outside databases Previous GC identifers: GC14P021017 GC14P021019 GC14P002064
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Summariesfor TOX4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: TOX4_HUMAN, O94842 Function : Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure andcell cycle progression during the transition from mitosis into interphase Gene Wiki entry for TOX4
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Genomic Viewsfor TOX4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000014.8 NC_018925.1 NT_026437.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TOX4 gene promoter:Max1 RP58 Pax-6 Lmo2 HNF-4alpha2 C/EBPalpha HNF-4alpha1 HFH-1 Cart-1 Ik-1 Other transcription factors Search SABiosciences Chromatin IP Primers for TOX4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOX4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2 TOX4 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14P021944: view genomic region
(about GC identifiers )
Start: 21,944,756 bp from pter End:
21,967,319 bp from pter
Size: 22,564 bases Orientation:
plus strand
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Proteinsfor TOX4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TOX4_HUMAN, O94842 See
protein sequence )Recommended Name: Size : 621 amino acids; 66195 DaSubunit : Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82 and PPP1CA or PPP1CB orPPP1CC. Interacts with PPP1R10/PNUTS
Subcellular location : Nucleus (Probable). Note=Associated with chromatinSequence caution : Sequence=BAA34457.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;Explore the universe of human proteins at neXtProt for TOX4: NX_O94842 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O94842 TOX4 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_055643.1 ENSEMBL proteins: ENSP00000402195 ENSP00000385102 ENSP00000392234 ENSP00000392482 ENSP00000406196 ENSP00000389333 ENSP00000262709 ENSP00000393080 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing TOX4 Antibody Products: Assay Products for TOX4:
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Protein
Domains /for TOX4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry O94842 ProtoNet protein and cluster: O94842
UniProtKB/Swiss-Prot: TOX4_HUMAN, O94842 Similarity : Contains 1 HMG box DNA-binding domain
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Functionfor TOX4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: TOX4_HUMAN, O94842 Function : Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure andcell cycle progression during the transition from mitosis into interphase
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TOX4 (NM_014828 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOX4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TOX4
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOX4
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing
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Pathways & Interactionsfor TOX4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TOX4 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/612 Interacting proteins for TOX4 (O94842 2 , 3 ENSP00000262709 4 via UniProtKB, MINT, STRING , and/or I2D (see all 612 )About this table
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Drugs & Compoundsfor TOX4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TOX4 TOX4
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Transcriptsfor TOX4 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TOX4 gene: NM_014828.2 Unigene Cluster for TOX4:
TOX high mobility group box family member 4 Hs.555910 [show with all ESTs ] Unigene Representative Sequence: NM_014828 13 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000416256 ENST00000405508 (uc001waz.3 uc010tlu.2 uc010tlv.2 )ENST00000476180 (uc001way.3 ) ENST00000455393 ENST00000447695 ENST00000457430 ENST00000494242 ENST00000455138 ENST00000487242 ENST00000473176 ENST00000463119 ENST00000262709 ENST00000448790 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TOX4 (NM_014828 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOX4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TOX4
Additional cDNA sequence: AB018280.1 AK022060.1 AK295913.1 AK298555.1 AK299807.1 AY305872.1 BC013689.1 BC020292.1 BC020727.1 BC035050.1
24/25 DOTS entries (see all 25 ): DT.100702386 DT.444736
DT.100770645 DT.100844608 DT.75100949 DT.120763155 DT.120763081 DT.100884678 DT.102835219 DT.100807352 DT.100884648 DT.100884651 DT.100806117 DT.120763088 DT.120763157 DT.120763175 DT.120763177 DT.120763185 DT.121223751 DT.40282672 DT.100810815 DT.120763112 DT.120763166 DT.95147968 24/407 AceView cDNA sequences (see all 407 ):
BM691155 BM792873 CB139739 BU845503 CD723382 H79968 AI277767 NM_014828 AA460232 BE673653 CD723507 AI381681 AB018280 AI080178 AA693518 BU677026 AA584365 AA478991 AI582648 BU173416 CR611395 CR607593 CF780719 AA454106 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TOX4 (see all 9 ) About this scheme ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 SP1 : - - - SP2 : - - SP3 : - - - - SP4 : - - SP5 :
ECgene alternative splicing isoforms for TOX4
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Expression for TOX4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TOX4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CCATAGATTT
About this image TOX4 expression in embryonic tissues and stem cells About this table See TOX4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TOX4 SOURCE GeneReport for Unigene cluster: Hs.555910 SABiosciences Custom PCR Arrays for TOX4 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOX4
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Orthologsfor TOX4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for TOX4 gene from 7/25 species (see all 25 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
lizard Reptilia TOX46
--
73(a)
1 ↔ 1
GL343466.1(476476-483987)
African clawed frog Amphibia Xl.338382
Xenopus laevis transcribed sequence with moderate similarity more
78.03(n)
BU910449.1
zebrafish Actinopterygii zgc:1751371
zgc:175137
55.99(n) 55.74(a)
100003353 NM_001128286.1 NP_001121758.1
fruit fly Insecta CG121041
CG12104
48.35(n) 40.1(a)
38187 NM_139372.2 NP_647629.1
worm Secernentea hmg-1.26
High mobility group protein 1.2
14(a)
possible ortholog
III(6280332-6283068)
thale cress eudicotyledons NFD6
FACT complex subunit SSRP1
4(a)
possible ortholog
3(10784889-10788729)
rice Liliopsida ----
SSRP1-like FACT complex subunit, putative, express... SSRP1-like FACT complex subunit, putative, express... 4(a) 4(a)
possible orthologpossible ortholog
1(4496719-4503407) 5(4965403-4971007)
ENSEMBL Gene Tree for TOX4 (if available)TreeFam Gene Tree for TOX4 (if available)
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Paralogsfor TOX4 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TOX4 gene TOX 2 TOX3 2 HMGB4 2 HMGB3 2 HMGB1 2 TOX2 2 HMGB2 2 6 SIMAP similar genes for TOX4 using alignment to 7 protein entries: TOX4_HUMAN (see all proteins ):TOX3 HMGB4 SMARCE1 Bbtx1 TOX2 TOX About GeneDecksing 1 Pseudogenes.org Pseudogene for TOX4 PGOHUM00000246033
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Genomic Variantsfor TOX4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 14 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for TOX4 (21944756 - 21967319 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 8 variations for TOX4 5 CNVs 5727 43899 101895 5318 61367 3 Indels 87135 87136 76579
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor TOX4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 614032
OMIM disorders : --5 : About MalaCards ocular toxoplasmosis toxoplasmosis ataxia malaria breast cancer Export disorders for TOX4 gene to outside databases
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Publicationsfor TOX4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TOX4 gene, integrated from 9 sources (see all 21 ):(articles sorted by number of sources associating them with TOX4) Utopia : connect your pdf to the dynamic
Identification and characterization of a novel human PP1 phosphatase complex. (PubMed id 20516061) 1 , 2 (2010) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452) 1 , 2 (1998) A census of human soluble protein complexes. (PubMed id 22939629) 1 (2012) Differential Epigenetic Regulation of TOX Subfamily High Mobility Group Box Genes in Lung and Breast Cancers. (PubMed id 22496870) 1 (2012) TOX4 and its binding partners recognize DNA adducts g enerated by platinum anticancer drugs. (PubMed id 21184731) 1 (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692) 2 (2011) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231) 2 (2010) A human MAP kinase interactome. (PubMed id 20936779) 1 (2010) Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068) 1 (2010)
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External Searches for TOX4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TOX4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TOX4 gene
(According to HUGE )
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Specialized Databases showing TOX4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for TOX4 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TOX4 gene: TOX4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TOX4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for TOX4 Browse OriGene Fluorogenic Cell Assay Kits Browse OriGene siRNAs OriGene 3'-UTR Clone for TOX4 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TOX4 OriGene Custom Protein Services for TOX4 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TOX4 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOX4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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TOX4 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOX4
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TOX4
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Aliases for TOX4
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Disorders / Diseases for TOX4
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Expression for TOX4
Function for TOX4
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Expression by the Database of Embryonic development, Stem cell research, and
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Anatomical Compartment 
Negative
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