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Aliases for TOX4 Gene

Aliases for TOX4 Gene

  • TOX High Mobility Group Box Family Member 4 2 3 5
  • KIAA0737 2 3 4
  • Epidermal Langerhans Cell Protein LCP1 3 4
  • C14orf92 3 4
  • Chromosome 14 Open Reading Frame 92 2
  • Migration-Inducing Protein 7 3
  • LCP1 3
  • MIG7 3

External Ids for TOX4 Gene

Previous HGNC Symbols for TOX4 Gene

  • C14orf92
  • KIAA0737

Previous GeneCards Identifiers for TOX4 Gene

  • GC14P021017
  • GC14P021019
  • GC14P021944
  • GC14P002064

Summaries for TOX4 Gene

GeneCards Summary for TOX4 Gene

TOX4 (TOX High Mobility Group Box Family Member 4) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is TOX3.

UniProtKB/Swiss-Prot for TOX4 Gene

  • Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

Gene Wiki entry for TOX4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOX4 Gene

Genomics for TOX4 Gene

Regulatory Elements for TOX4 Gene

Enhancers for TOX4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F021509 0.2 ENCODE 24.5 +34.4 34444 2.3 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 METTL3 TOX4 CHD8 SUPT16H RNASE4 PIR42881
GH14F021498 0.8 ENCODE 21.9 +22.3 22272 0.8 CTCF PKNOX1 ARID4B EBF1 RAD21 GATA3 POLR2A SCRT2 ZNF143 SMC3 TOX4 ENSG00000257096 SALL2 METTL3 PIR42881 RAB2B
GH14F021512 0.8 ENCODE 14.4 +35.6 35638 0.1 L3MBTL2 THRAP3 ADNP MLLT1 TOX4 METTL3 GC14P021517
GH14F021307 0.6 Ensembl ENCODE 14.2 -168.0 -167968 2.3 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 YY1 ELK1 GATA2 RPGRIP1 TOX4 PARP2 HNRNPC TEP1 METTL3 SNORD9 SNORD8 UBA52P2 ENSG00000260830
GH14F021495 0.5 ENCODE 13.6 +19.0 19000 0.1 ATF3 HLF CEBPB ATF2 TOX4 PIR42881 RAB2B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TOX4 on UCSC Golden Path with GeneCards custom track

Promoters for TOX4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000096762 603 2801 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207

Genomic Location for TOX4 Gene

Chromosome:
14
Start:
21,476,597 bp from pter
End:
21,499,177 bp from pter
Size:
22,581 bases
Orientation:
Plus strand

Genomic View for TOX4 Gene

Genes around TOX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOX4 Gene

Proteins for TOX4 Gene

  • Protein details for TOX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94842-TOX4_HUMAN
    Recommended name:
    TOX high mobility group box family member 4
    Protein Accession:
    O94842
    Secondary Accessions:
    • B4DPY8
    • B4DSM0
    • E7EV69

    Protein attributes for TOX4 Gene

    Size:
    621 amino acids
    Molecular mass:
    66195 Da
    Quaternary structure:
    • Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82 and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS.
    SequenceCaution:
    • Sequence=BAA34457.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TOX4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TOX4 Gene

Post-translational modifications for TOX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TOX4 Gene

Domains & Families for TOX4 Gene

Protein Domains for TOX4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TOX4 Gene

Graphical View of Domain Structure for InterPro Entry

O94842

UniProtKB/Swiss-Prot:

TOX4_HUMAN :
  • Contains 1 HMG box DNA-binding domain.
Domain:
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with TOX4: view

No data available for Gene Families for TOX4 Gene

Function for TOX4 Gene

Molecular function for TOX4 Gene

UniProtKB/Swiss-Prot Function:
Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

Gene Ontology (GO) - Molecular Function for TOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 20516061
genes like me logo Genes that share ontologies with TOX4: view
genes like me logo Genes that share phenotypes with TOX4: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TOX4 Gene

Localization for TOX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOX4 Gene

Nucleus. Note=Associated with chromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOX4 Gene COMPARTMENTS Subcellular localization image for TOX4 gene
Compartment Confidence
nucleus 5
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
GO:0000785 chromatin IDA 20516061
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0072357 PTW/PP1 phosphatase complex IDA 20516061
genes like me logo Genes that share ontologies with TOX4: view

Pathways & Interactions for TOX4 Gene

SuperPathways for TOX4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TOX4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TOX4 Gene

Transcripts for TOX4 Gene

Unigene Clusters for TOX4 Gene

TOX high mobility group box family member 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOX4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - -
SP5:
SP6: -
SP7: - -
SP8:
SP9: - -

Relevant External Links for TOX4 Gene

GeneLoc Exon Structure for
TOX4
ECgene alternative splicing isoforms for
TOX4

Expression for TOX4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TOX4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TOX4 Gene

This gene is overexpressed in Lymph node (11.4), Testis (10.0), Fetal Brain (9.3), Pancreas (6.6), and CD8 Tcells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TOX4 Gene



Protein tissue co-expression partners for TOX4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TOX4 Gene:

TOX4

SOURCE GeneReport for Unigene cluster for TOX4 Gene:

Hs.555910
genes like me logo Genes that share expression patterns with TOX4: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TOX4 Gene

Orthologs for TOX4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOX4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOX4 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia TOX4 34 35
  • 94.18 (n)
cow
(Bos Taurus)
Mammalia TOX4 34 35
  • 93.65 (n)
mouse
(Mus musculus)
Mammalia Gm5828 35
  • 91 (a)
OneToMany
Tox4 34 16 35
  • 89.93 (n)
rat
(Rattus norvegicus)
Mammalia Tox4 34
  • 89.88 (n)
oppossum
(Monodelphis domestica)
Mammalia TOX4 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOX4 35
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOX4 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tox4 34
  • 67.12 (n)
LOC395028 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.33838 34
zebrafish
(Danio rerio)
Actinopterygii TOX4 (2 of 2) 35
  • 46 (a)
OneToMany
tox4 35
  • 40 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12104 35
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hmg-6 35
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POB3 35
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11202 35
  • 23 (a)
OneToOne
Species where no ortholog for TOX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TOX4 Gene

ENSEMBL:
Gene Tree for TOX4 (if available)
TreeFam:
Gene Tree for TOX4 (if available)

Paralogs for TOX4 Gene

Paralogs for TOX4 Gene

(2) SIMAP similar genes for TOX4 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for TOX4 Gene

genes like me logo Genes that share paralogs with TOX4: view

Variants for TOX4 Gene

Sequence variations from dbSNP and Humsavar for TOX4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10135215 -- 21,479,698(+) TCTTA(A/G)TTGCC intron-variant
rs10141933 -- 21,481,791(+) AATAT(A/T)TTGTT intron-variant
rs10142478 -- 21,481,668(+) tctta(A/C)tagct intron-variant
rs10431656 -- 21,497,588(+) agtgg(C/T)gcgac utr-variant-3-prime
rs1060722 -- 21,492,657(+) ACCCT(C/T)TCATC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TOX4 Gene

Variant ID Type Subtype PubMed ID
esv2080110 CNV deletion 18987734
esv2422459 CNV duplication 17116639
esv2506236 CNV deletion 19546169
esv2666055 CNV deletion 23128226
esv2748459 CNV deletion 23290073
esv3246830 CNV deletion 24192839
esv3551214 CNV deletion 23714750
esv3633716 CNV gain 21293372
esv3633717 CNV loss 21293372
esv3633718 CNV gain 21293372
esv8853 CNV loss 19470904
esv994931 CNV deletion 20482838
nsv1069985 CNV deletion 25765185
nsv1112643 CNV deletion 24896259
nsv1144710 CNV deletion 24896259
nsv85879 CNV deletion 16902084
nsv957490 CNV deletion 24416366

Variation tolerance for TOX4 Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOX4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TOX4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOX4 Gene

Disorders for TOX4 Gene

Relevant External Links for TOX4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TOX4

No disorders were found for TOX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOX4 Gene

Publications for TOX4 Gene

  1. Identification and characterization of a novel human PP1 phosphatase complex. (PMID: 20516061) Lee J.H. … Skalnik D.G. (J. Biol. Chem. 2010) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4 64
  4. Analysis of HIV-1 Gag protein interactions via biotin ligase tagging. (PMID: 25631074) Ritchie C. … Barklis E. (J. Virol. 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for TOX4 Gene

Sources for TOX4 Gene

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