Aliases for TOX3 Gene
External Ids for TOX3 Gene
Previous HGNC Symbols for TOX3 Gene
Previous GeneCards Identifiers for TOX3 Gene
The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]
GeneCards Summary for TOX3 Gene
TOX3 (TOX High Mobility Group Box Family Member 3) is a Protein Coding gene. Diseases associated with TOX3 include Restless Legs Syndrome and Estrogen-Receptor Positive Breast Cancer. GO annotations related to this gene include protein homodimerization activity and phosphoprotein binding. An important paralog of this gene is TOX.
UniProtKB/Swiss-Prot for TOX3 Gene
Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.