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Aliases for TOX3 Gene

Aliases for TOX3 Gene

  • TOX High Mobility Group Box Family Member 3 2 3
  • CAG Trinucleotide Repeat-Containing Gene F9 Protein 3 4
  • Trinucleotide Repeat-Containing Gene 9 Protein 3 4
  • Trinucleotide Repeat Containing 9 2 3
  • TNRC9 3 4
  • CAGF9 3 4

External Ids for TOX3 Gene

Previous HGNC Symbols for TOX3 Gene

  • TNRC9

Previous GeneCards Identifiers for TOX3 Gene

  • GC16M051030
  • GC16M038359

Summaries for TOX3 Gene

Entrez Gene Summary for TOX3 Gene

  • The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]

GeneCards Summary for TOX3 Gene

TOX3 (TOX High Mobility Group Box Family Member 3) is a Protein Coding gene. Diseases associated with TOX3 include breast cancer. GO annotations related to this gene include protein homodimerization activity and phosphoprotein binding. An important paralog of this gene is SSRP1.

UniProtKB/Swiss-Prot for TOX3 Gene

  • Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOX3 Gene

Genomics for TOX3 Gene

Regulatory Elements for TOX3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TOX3 Gene

Start:
52,437,770 bp from pter
End:
52,547,802 bp from pter
Size:
110,033 bases
Orientation:
Minus strand

Genomic View for TOX3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TOX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOX3 Gene

Proteins for TOX3 Gene

  • Protein details for TOX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15405-TOX3_HUMAN
    Recommended name:
    TOX high mobility group box family member 3
    Protein Accession:
    O15405
    Secondary Accessions:
    • B4DRD0
    • B5MCW4

    Protein attributes for TOX3 Gene

    Size:
    576 amino acids
    Molecular mass:
    63342 Da
    Quaternary structure:
    • Homodimer. Interacts with CREB1; the interaction is not depolarization dependent. Interacts with CREBBP (via C-terminus) (By similarity). Interacts (via HGM box) with CITED1 (via C-terminus); the interaction increases estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with CREB1 (phosphorylated form).

    Alternative splice isoforms for TOX3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TOX3 Gene

Proteomics data for TOX3 Gene at MOPED

Post-translational modifications for TOX3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TOX3 Gene

No data available for DME Specific Peptides for TOX3 Gene

Domains for TOX3 Gene

Gene Families for TOX3 Gene

HGNC:
  • TNRC :Trinucleotide (CAG) repeat containing

Protein Domains for TOX3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O15405

UniProtKB/Swiss-Prot:

TOX3_HUMAN :
  • O15405
Domain:
  • the C-terminus is required for calcium responsiveness but not for transactivation activity.
  • The N-terminus is absolutely necessary for transactivation activity.
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with TOX3: view

Function for TOX3 Gene

Molecular function for TOX3 Gene

UniProtKB/Swiss-Prot Function: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.
UniProtKB/Swiss-Prot Induction: Up-regulated by GPR39 in neuronal cells.

Gene Ontology (GO) - Molecular Function for TOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 21172805
GO:0005515 protein binding IPI 21172805
GO:0034056 estrogen response element binding IDA 21172805
GO:0042803 protein homodimerization activity IDA 21172805
GO:0051219 phosphoprotein binding IPI 21172805
genes like me logo Genes that share ontologies with TOX3: view

Phenotypes for TOX3 Gene

GenomeRNAi human phenotypes for TOX3:
genes like me logo Genes that share phenotypes with TOX3: view

Animal Model Products

CRISPR Products

miRNA for TOX3 Gene

miRTarBase miRNAs that target TOX3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TOX3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TOX3 Gene

Localization for TOX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOX3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOX3 Gene COMPARTMENTS Subcellular localization image for TOX3 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with TOX3: view

Pathways for TOX3 Gene

SuperPathways for TOX3 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0043524 negative regulation of neuron apoptotic process IDA 21172805
GO:0045893 positive regulation of transcription, DNA-templated IDA 21172805
genes like me logo Genes that share ontologies with TOX3: view

No data available for Pathways by source for TOX3 Gene

Transcripts for TOX3 Gene

Unigene Clusters for TOX3 Gene

TOX high mobility group box family member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TOX3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TOX3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOX3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for TOX3 Gene

GeneLoc Exon Structure for
TOX3
ECgene alternative splicing isoforms for
TOX3

Expression for TOX3 Gene

mRNA expression in normal human tissues for TOX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TOX3 Gene

This gene is overexpressed in Minor Salivary Gland (5.1), Colon - Transverse (4.9), and Stomach (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOX3 Gene

SOURCE GeneReport for Unigene cluster for TOX3 Gene Hs.460789

mRNA Expression by UniProt/SwissProt for TOX3 Gene

O15405-TOX3_HUMAN
Tissue specificity: Expressed mainly in epithelial cells. Expressed in the central nervous system (CNS), in the ileum and within the brain in the frontal and occipital lobe.
genes like me logo Genes that share expressions with TOX3: view

In Situ Assay Products

Orthologs for TOX3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOX3 35
  • 99.85 (n)
  • 100 (a)
TOX3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TOX3 35
  • 91.44 (n)
  • 96.76 (a)
TOX3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOX3 35
  • 91.06 (n)
  • 97.07 (a)
TOX3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tox3 35
  • 90.8 (n)
  • 95.4 (a)
Tox3 16
Tox3 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TOX3 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOX3 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tox3 35
  • 90.73 (n)
  • 95.99 (a)
chicken
(Gallus gallus)
Aves TOX3 35
  • 80.58 (n)
  • 90.14 (a)
TOX3 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOX3 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tox3 35
  • 75.52 (n)
  • 83.6 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.16177 35
tox3 35
  • 69.87 (n)
  • 72.83 (a)
tox3 36
  • 64 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POB3 36
  • 7 (a)
OneToMany
Species with no ortholog for TOX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOX3 Gene

ENSEMBL:
Gene Tree for TOX3 (if available)
TreeFam:
Gene Tree for TOX3 (if available)

Paralogs for TOX3 Gene

Paralogs for TOX3 Gene

Selected SIMAP similar genes for TOX3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TOX3: view

Variants for TOX3 Gene

Sequence variations from dbSNP and Humsavar for TOX3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs40839 -- 52,463,430(+) TAATC(A/G)CTTGT intron-variant
rs40840 -- 52,466,475(+) GTAAA(C/T)TTACT intron-variant
rs40841 -- 52,466,510(+) GGCAC(A/G)TGCTA intron-variant
rs40842 -- 52,466,659(+) TTTTG(C/T)TCAGG intron-variant
rs42198 -- 52,441,642(+) ATCAA(A/G)CAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOX3 Gene

Variant ID Type Subtype PubMed ID
nsv833229 CNV Loss 17160897
nsv457488 CNV Loss 19166990
nsv523458 CNV Loss 19592680
nsv833230 CNV Loss 17160897

Relevant External Links for TOX3 Gene

HapMap Linkage Disequilibrium report
TOX3
Human Gene Mutation Database (HGMD)
TOX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOX3 Gene

Disorders for TOX3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TOX3 Gene including...

Search for TOX3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TOX3 Gene

Relevant External Links for TOX3

Genetic Association Database (GAD)
TOX3
Human Genome Epidemiology (HuGE) Navigator
TOX3
genes like me logo Genes that share disorders with TOX3: view

No data available for UniProtKB/Swiss-Prot for TOX3 Gene

Publications for TOX3 Gene

  1. cDNAs with long CAG trinucleotide repeats from human brain. (PMID: 9225980) Margolis R.L. … Ross C.A. (Hum. Genet. 1997) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Performance of common genetic variants in breast-cancer risk models. (PMID: 20237344) Wacholder S. … Hunter D.J. (N. Engl. J. Med. 2010) 3 48
  4. Fine scale mapping of the breast cancer 16q12 locus. (PMID: 20332101) Udler M.S. … Dunning A.M. (Hum. Mol. Genet. 2010) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for TOX3 Gene

Sources for TOX3 Gene

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