Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TOX3 Gene

protein-coding   GIFtS: 51
GCID: GC16M052471

TOX High Mobility Group Box Family Member 3

(Previous name: trinucleotide repeat containing 9)
(Previous symbol: TNRC9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TOX High Mobility Group Box Family Member 31 2
TNRC91 2 3
Trinucleotide Repeat Containing 91 2
Trinucleotide Repeat-Containing Gene 9 Protein2 3
CAGF92 3
CAG Trinucleotide Repeat-Containing Gene F9 Protein2 3

External Ids:    HGNC: 119721   Entrez Gene: 273242   Ensembl: ENSG000001034607   OMIM: 6114165   UniProtKB: O154053   

Export aliases for TOX3 gene to outside databases

Previous GC identifers: GC16M051030 GC16M038359


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TOX3 Gene:
The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding
of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG
repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast
cancer. Two transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq,
Apr 2009)

GeneCards Summary for TOX3 Gene: 
TOX3 (TOX high mobility group box family member 3) is a protein-coding gene. Diseases associated with TOX3 include estrogen-receptor positive breast cancer, and breast cancer susceptibility. GO annotations related to this gene include phosphoprotein binding and protein homodimerization activity. An important paralog of this gene is TOX.

UniProtKB/Swiss-Prot: TOX3_HUMAN, O15405
Function: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation
through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing
pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for
depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to
the estrogen-responsive C3 promoter region




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TOX3 gene promoter:
         HOXA3   MyoD   IRF-1   RORalpha1   AREB6   S8   SRY   FOXC1   Sox9   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TOX3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.1   Ensembl cytogenetic band:  16q12.1   HGNC cytogenetic band: 16q12.1

TOX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOX3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M052471:  view genomic region     (about GC identifiers)

Start:
52,471,917 bp from pter      End:
52,581,714 bp from pter
Size:
109,798 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TOX3_HUMAN, O15405 (See protein sequence)
Recommended Name: TOX high mobility group box family member 3  
Size: 576 amino acids; 63342 Da
Subunit: Homodimer. Interacts with CREB1; the interaction is not depolarization dependent. Interacts with CREBBP
(via C-terminus) (By similarity). Interacts (via HGM box) with CITED1 (via C-terminus); the interaction increases
estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with CREB1
(phosphorylated form)
Subcellular location: Nucleus (Probable)
Secondary accessions: B4DRD0 B5MCW4
Alternative splicing: 2 isoforms:  O15405-1   O15405-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TOX3: NX_O15405

Explore proteomics data for TOX3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15405

  • TOX3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TOX3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001073899.2  NP_001139660.1  

    ENSEMBL proteins: 
     ENSP00000385705   ENSP00000219746   ENSP00000457401   ENSP00000463843  

    Human Recombinant Protein Products for TOX3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TOX3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TOX3
    GenScript Custom Purified and Recombinant Proteins Services for TOX3
    Novus Biologicals TOX3 Protein
    Novus Biologicals TOX3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TOX3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TOX3 for ontologies           About GeneDecksing



    TOX3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TOX3
    GenScript Custom Superior Antibodies Services for TOX3
    Novus Biologicals TOX3 Antibodies
    Abcam antibodies for TOX3
    Cloud-Clone Corp. Antibodies for TOX3 
    ThermoFisher Antibody for TOX3
    LSBio Antibodies in human, mouse, rat for TOX3 

    Assay Products for TOX3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TOX3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TOX3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TOX3 
    Cloud-Clone Corp. CLIAs for TOX3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TNRC: Trinucleotide (CAG) repeat containing

    1 InterPro protein domain:
     IPR009071 HMG_box_dom

    Graphical View of Domain Structure for InterPro Entry O15405

    ProtoNet protein and cluster: O15405

    UniProtKB/Swiss-Prot: TOX3_HUMAN, O15405
    Domain: the C-terminus is required for calcium responsiveness but not for transactivation activity (By similarity)
    Domain: The N-terminus is absolutely necessary for transactivation activity (By similarity)
    Similarity: Contains 1 HMG box DNA-binding domain


    TOX3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOX3_HUMAN, O15405
    Function: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation
    through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing
    pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for
    depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to
    the estrogen-responsive C3 promoter region
    Induction: Up-regulated by GPR39 in neuronal cells

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA--
    GO:0005515protein binding IPI--
    GO:0034056estrogen response element binding IDA--
    GO:0042803protein homodimerization activity IDA--
    GO:0051219phosphoprotein binding IPI--
         
    TOX3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TOX3:
     Increased S DNA content  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TOX3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TOX3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TOX3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TOX3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOX3
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate TOX3 (see all 59):
    hsa-miR-323-3p hsa-miR-520e hsa-miR-302d hsa-miR-485-3p hsa-miR-519a hsa-miR-218 hsa-miR-548l hsa-miR-372
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TOX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOX3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TOX3
    Sirion Biotech Customized adenovirus for overexpression of TOX3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TOX3 (see all 11)
    OriGene ORF clones in mouse, rat for TOX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TOX3 (NM_001080430)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOX3
    Sirion Biotech Customized lentivirus for stable overexpression of TOX3 
                         Customized lentivirus expression plasmids for stable overexpression of TOX3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TOX3
    Search LifeMap BioReagents cell lines for TOX3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOX3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TOX3

    5/7 Interacting proteins for TOX3 (O154052, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CERS2Q96G233I2D: score=1 
    DNMT1P263583I2D: score=1 
    GTF3C1Q127893I2D: score=1 
    PHF2O751513I2D: score=1 
    SOX6P357123I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006915apoptotic process IEA--
    GO:0043524negative regulation of neuron apoptotic process IDA--
    GO:0045893positive regulation of transcription, DNA-dependent IDA--

    TOX3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TOX3

    Search CenterWatch for drugs/clinical trials and news about TOX3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TOX3 gene (2 alternative transcripts): 
    NM_001080430.2  NM_001146188.1  

    Unigene Cluster for TOX3:

    TOX high mobility group box family member 3
    Hs.460789  [show with all ESTs]
    Unigene Representative Sequence: AK095095
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407228(uc010vgt.1) ENST00000566696 ENST00000219746(uc002egw.2)
    ENST00000563091 ENST00000568436
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOX3
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate TOX3 (see all 59):
    hsa-miR-323-3p hsa-miR-520e hsa-miR-302d hsa-miR-485-3p hsa-miR-519a hsa-miR-218 hsa-miR-548l hsa-miR-372
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TOX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOX3
    Clone
    Products:
         
    OriGene clones in human, mouse for TOX3 (see all 11)
    OriGene ORF clones in mouse, rat for TOX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TOX3 (NM_001080430)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOX3
    Sirion Biotech Customized lentivirus for stable overexpression of TOX3 
                         Customized lentivirus expression plasmids for stable overexpression of TOX3 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TOX3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TOX3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOX3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOX3

    Additional mRNA sequence: 

    AK025084.1 AK027006.1 AK095095.1 AK299202.1 U80736.1 

    4 DOTS entries:

    DT.310339  DT.100019774  DT.102826728  DT.86852392 

    24/34 AceView cDNA sequences (see all 34):

    AI589250 AI274758 BI492797 BM825570 CA776993 AW960020 AU132512 AA227219 
    CA773487 AW602304 AK025084 BQ631338 U80736 AK095095 AW157368 BM823114 
    AK027006 BQ631616 H39709 AA367468 CB158332 AA226866 AW389850 AA595253 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TOX3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:                                                                  
    SP2:                                            -                     
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for TOX3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TOX3 expression in normal human tissues (normalized intensities)      TOX3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TOX3 Expression
    About this image


    TOX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 7 entries
             hIPS1
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
             spinal cord/lateral wall/ventricular layer   
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod

    See TOX3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TOX3

    SOURCE GeneReport for Unigene cluster: Hs.460789

    UniProtKB/Swiss-Prot: TOX3_HUMAN, O15405
    Tissue specificity: Expressed mainly in epithelial cells. Expressed in the central nervous system (CNS), in the
    ileum and within the brain in the frontal and occipital lobe

        SABiosciences Expression via Pathway-Focused PCR Array including TOX3: 
              Lung Cancer in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TOX3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TOX3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOX3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOX3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TOX3 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tox31 , 5 TOX high mobility group box family member 31, 5 90.71(n)1
    95.47(a)1
      8 (43.96 cM)5
    2445791  NM_172913.31  NP_766501.21 
     902470405 
    chicken
    (Gallus gallus)
    Aves TOX31 TOX high mobility group box family member 3 81.9(n)
    90.53(a)
      415724  XM_414090.3  XP_414090.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    83(a)
    82(a)
    1 ↔ many
    1 ↔ many
    GL343227.1(54130-92957)
    GL344482.1(1082-6020)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.161772 Transcribed sequence with weak similarity to protein more 82.53(n)    BG883581.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dsp16
    CG121046
    --
    9(a)
    26(a)
    possible ortholog
    1 ↔ many
    X(16227645-16234657)
    3L(1600726-1602674)
    worm
    (Caenorhabditis elegans)
    Secernentea hmg-1.26
    High mobility group protein 1.2
    13(a)
    possible ortholog
    III(6280383-6283119)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NHP6A6
    NHP6B6
    High-mobility group (HMG) protein that binds to an...
    High-mobility group (HMG) protein that binds to an...
    32(a)
    30(a)
    many ↔ many
    many ↔ many
    XVI(665693-665974)
    II(426190-426489)


    ENSEMBL Gene Tree for TOX3 (if available)
    TreeFam Gene Tree for TOX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TOX3 gene
    TOX2  TOX42  SSRP12  TOX22  
    4 SIMAP similar genes for TOX3 using alignment to 3 protein entries:     TOX3_HUMAN (see all proteins):
    TOX4    Bbtx1    TOX    TOX2

    TOX3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2141 SNPs in TOX3 are shown (see all 2141)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs671454431,2
    C--52471702(+) AAAAA-/AAGACAA 2 -- ds50011Minor allele frequency- AA:0.00NA 2
    rs106536611,2
    C--52472421(+) TCACATTTCT/
            
    TTTCT
    2 -- ut311Minor allele frequency- -:0.50NA 2
    rs570799651,2
    C--52472422(+) TTCTT-/TTCT  
     T
    /TTTCT
    CTAAT
    4 -- ut311NA 2
    rs2010237251,2
    C--52472428(-) AATTAA/GAAGAA 2 -- ut310--------
    rs349337981,2
    C--52480592(+) ATTGA-/TTTTTT 2 -- int13Minor allele frequency- T:0.17NA CSA 6
    rs113720271,2
    C--52486597(+) AAAAAA/-GAAAT 2 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs113013401,2
    C--52487100(+) TTTTTT/-AGATG 2 -- int1 trp32Minor allele frequency- -:0.25NA CSA 4
    rs114546081,2
    C--52514842(+) TTTTT-/T/TT  
            
    ATTGT
    2 -- int11NA 2
    rs456223341,2
    C,F--52517715(+) CTCAG-/GTGATC 2 -- int12Minor allele frequency- G:0.37EU CSA 80
    rs1138469161,2
    C--52519058(+) TGTGTGT/-ATATA 2 -- int11Minor allele frequency- -:0.00CSA 2

    HapMap Linkage Disequilibrium report for TOX3 (52471917 - 52581714 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TOX3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv523458CNV Loss19592680
    nsv457488CNV Loss19166990
    nsv833230CNV Loss17160897
    nsv833229CNV Loss17160897


    Human Gene Mutation Database (HGMD): TOX3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TOX3
    DNA2.0 Custom Variant and Variant Library Synthesis for TOX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611416    OMIM disorders: --

    10 diseases for TOX3:    About MalaCards
    estrogen-receptor positive breast cancer    breast cancer susceptibility    breast cancer    familial breast cancer
    polycystic ovary syndrome    pancreatic cancer    ovarian cancer    pancreatitis
    lung cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for TOX3:
    Breast cancer

    TOX3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TOX3
    Human Genome Epidemiology (HuGE) Navigator: TOX3 (24 documents)

    Export disorders for TOX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TOX3 gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with TOX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNAs with long CAG trinucleotide repeats from human brain. (PubMed id 9225980)1, 2, 3 Margolis R.L.... Ross C.A. (1997)
    2. Genome-wide association study identifies novel restles s legs syndrome susceptibility loci on 2p14 and 16q12.1. (PubMed id 21779176)1, 4 Winkelmann J....Meitinger T. (2011)
    3. TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex. (PubMed id 21172805)1, 2 Dittmer S.... Methner A. (2011)
    4. Fine scale mapping of the breast cancer 16q12 locus. (PubMed id 20332101)1, 4 Udler M.S....Dunning A.M. (2010)
    5. Breast cancer susceptibility variants alter risk in f amilial ovarian cancer. (PubMed id 20502973)1, 4 Latif A....Newman W.G. (2010)
    6. Common genetic variants associated with breast cancer and mammographic density measures that predict disease. (PubMed id 20145138)1, 4 Odefrey F....Southey M.C. (2010)
    7. Birth weight, breast cancer susceptibility loci, and breast cancer risk. (PubMed id 20054709)1, 4 Tamimi R.M....Hall P. (2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    9. Performance of common genetic variants in breast-canc er risk models. (PubMed id 20237344)1, 4 Wacholder S....Hunter D.J. (2010)
    10. Distribution of FGFR2, TNRC9, MAP3K1, LSP1, and 8q24 alleles in genetically enriched breast cancer patients versus elderly tumor-fre e women. (PubMed id 20417875)1, 4 Gorodnova T.V....Imyanitov E.N. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27324 HGNC: 11972 AceView: TNRC9 Ensembl:ENSG00000103460 euGenes: HUgn27324
    ECgene: TOX3 H-InvDB: TOX3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TOX3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TOX3 gene:
    Search GeneIP for patents involving TOX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TOX3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TOX3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TOX3  
     OriGene qSTAR qPCR primer pairs in human, mouse for TOX3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TOX3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TOX3   OriGene Custom Protein Services for TOX3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TOX3
     QIAGEN SeqTarget long-range PCR primers for resequencing TOX3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOX3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOX3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOX3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOX3
     GenScript Custom Purified and Recombinant Proteins Services for TOX3 GenScript cDNA clones with any tag delivered in your preferred vector for TOX3
     GenScript Custom Assay Services for TOX3 GenScript Custom Superior Antibodies Services for TOX3
     GenScript Custom overexpressing Cell Line Services for TOX3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TOX3 promoter
     Search Chromatin IP Primers for TOX3
     RT2 qPCR Primer Assay in human, mouse, rat TOX3
     Search GNC Networks for TOX3
     SABiosciences PCR Arrays including human, mouse, rat TOX3
     Search Tocris compounds for TOX3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TOX3 antibodies
     TOX3 proteins
     TOX3 lysates
     Antibodies for TOX3
     See all of Abcam's Antibodies, Kits and Proteins for TOX3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TOX3
     Antibodies for TOX3
     ELISAs for TOX3
     CLIAs for TOX3
     Search LifeMap BioReagents cell lines for TOX3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOX3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TOX3
     Browse SwitchGear Promoter luciferase reporter plasmids for TOX3
     ThermoFisher Antibody for TOX3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOX3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TOX3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TOX3
    Customized:
     lentivirus for stable overexpression of TOX3
     lentivirus expression plasmids for stable overexpression of TOX3
     adenovirus for overexpression of TOX3
     LSBio Antibodies in human, mouse, rat for TOX3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TOX3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4